|
Name |
Accession |
Description |
Interval |
E-value |
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
234-460 |
2.53e-48 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 166.24 E-value: 2.53e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 234 IELHIKQLKEEKEKQKDFLDRITHELKTPLTAIIGYVDLI--PKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKYGT 311
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLldEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 312 STFEVSPTVVDIKELAEEAVSIVKPRLQQFEIEVINEL--TDVHVLADFDKTKQIFLNVLDNTIKYSDA-TQIRMNVIVS 388
Cdd:COG2205 82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLppELPLVYADPELLEQVLANLLDNAIKYSPPgGTITISARRE 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1452482242 389 EHEAKVFVHDDGIGIDEGVLAEWNESP-GGKVLPSSYGNGYGLYICQEIMNKQGGSMRIESSEEMGTTIFITF 460
Cdd:COG2205 162 GDGVRISVSDNGPGIPEEELERIFERFyRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
174-460 |
5.67e-47 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 167.04 E-value: 5.67e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 174 LVAAGIFFAIRLARSLHKPIDQLRQMAQRLANGDYKSKIELNEYVEIAQLSASFNAMADGIELH-IKQLKEEKEKQKDFL 252
Cdd:COG5002 90 LLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERdITELERLEQMRREFV 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 253 DRITHELKTPLTAIIGYVDLI--PKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKYGTSTFEVSPTVVDIKELAEEA 330
Cdd:COG5002 170 ANVSHELRTPLTSIRGYLELLldGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEV 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 331 VSIVKPRLQQFEIEVINEL--TDVHVLADFDKTKQIFLNVLDNTIKYSDA-TQIRMNVIVSEHEAKVFVHDDGIGIDEGV 407
Cdd:COG5002 250 VEELRPLAEEKGIELELDLpeDPLLVLGDPDRLEQVLTNLLDNAIKYTPEgGTITVSLREEDDQVRISVRDTGIGIPEED 329
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1452482242 408 LA-----------EWNESPGgkvlpssyGNGYGLYICQEIMNKQGGSMRIESSEEMGTTIFITF 460
Cdd:COG5002 330 LPriferfyrvdkSRSRETG--------GTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
174-460 |
3.37e-44 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 158.15 E-value: 3.37e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 174 LVAAGIFFAIRLARSLHKPIDQLRQMAQRLANGDYKSKIELNEYVEIAQLSASFNAMADGIELHIKQLKEEKEKQKDFLD 253
Cdd:COG0642 36 LLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 254 RITHELKTPLTAIIGYVDLIpKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKYGTSTFEVSPTVVDIKELAEEAVSI 333
Cdd:COG0642 116 NVSHELRTPLTAIRGYLELL-LEELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVEL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 334 VKPRLQQFEIEVINELTD--VHVLADFDKTKQIFLNVLDNTIKYSDA-TQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAE 410
Cdd:COG0642 195 FRPLAEEKGIELELDLPDdlPTVRGDPDRLRQVLLNLLSNAIKYTPEgGTVTVSVRREGDRVRISVEDTGPGIPPEDLER 274
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1452482242 411 WNEsPGGKVLPSSYGNGY--GLYICQEIMNKQGGSMRIESSEEMGTTIFITF 460
Cdd:COG0642 275 IFE-PFFRTDPSRRGGGTglGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
163-460 |
5.26e-36 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 137.79 E-value: 5.26e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 163 VGWTFLMTSLCLVAAGIFFAIRLARSLHKPIDQLRQMAQRLANGDYKSKIELNEYVEIAQLSASFNAMADGIelhiKQLK 242
Cdd:COG5000 7 FLLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQL----KEQR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 243 EEKEKQKDFLD--------------------------------------------------------------------- 253
Cdd:COG5000 83 EELEERRRYLEtilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeiel 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 254 --------------------------------------------RITHELKTPLTAIIGYVDLI-----PKLKA-KEDVQ 283
Cdd:COG5000 163 trdgrrtllvrasplrddgyvivfdditellraerlaawgelarRIAHEIKNPLTPIQLSAERLrrklaDKLEEdREDLE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 284 ESLRYVAVESERLLSLVEELLKSSKYGTSTFEVsptvVDIKELAEEAVSIVKPRLQQFEIEVINELTDVHVLADFDKT-- 361
Cdd:COG5000 243 RALDTIIRQVDRLKRIVDEFLDFARLPEPQLEP----VDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDql 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 362 KQIFLNVLDNTIkysDAT----QIRMNVIVSEHEAKVFVHDDGIGIDEGVLAewnespggKVL-------PSsyGNGYGL 430
Cdd:COG5000 319 EQVLINLLKNAI---EAIeeggEIEVSTRREDGRVRIEVSDNGPGIPEEVLE--------RIFepffttkPK--GTGLGL 385
|
410 420 430
....*....|....*....|....*....|
gi 1452482242 431 YICQEIMNKQGGSMRIESSEEMGTTIFITF 460
Cdd:COG5000 386 AIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
234-465 |
1.86e-30 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 123.74 E-value: 1.86e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 234 IELHIKQLKEEKEKQKDFLDRITHELKTPLTAIIGYVDLI---PKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKYG 310
Cdd:COG4251 268 LEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLeedYGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVG 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 311 TStfEVSPTVVDIKELAEEAVSIVKPRLQQFEIEV-INELTDVHvlADFDKTKQIFLNVLDNTIKYSD---ATQIRMNVI 386
Cdd:COG4251 348 RQ--ELEFEPVDLNELLEEVLEDLEPRIEERGAEIeVGPLPTVR--GDPTLLRQVFQNLISNAIKYSRpgePPRIEIGAE 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 387 VSEHEAKVFVHDDGIGIDE-------GV---LAEWNESPggkvlpssyGNGYGLYICQEIMNKQGGSMRIESSEEMGTTI 456
Cdd:COG4251 424 REGGEWVFSVRDNGIGIDPeyaekifEIfqrLHSRDEYE---------GTGIGLAIVKKIVERHGGRIWVESEPGEGATF 494
|
....*....
gi 1452482242 457 FITflLPKR 465
Cdd:COG4251 495 YFT--LPKA 501
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
255-460 |
3.13e-27 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 112.20 E-value: 3.13e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 255 ITHELKTPLTAIIGYVDL----IPKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKYGtstfEVSPTVVDIKELAEEA 330
Cdd:COG4191 149 IAHEINNPLAAILGNAELlrrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRD----EEEREPVDLNELIDEA 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 331 VSIVKPRLQQFEIEVINELTD--VHVLADFDKTKQIFLNVLDNTIkysDAT------QIRMNVIVSEHEAKVFVHDDGIG 402
Cdd:COG4191 225 LELLRPRLKARGIEVELDLPPdlPPVLGDPGQLEQVLLNLLINAI---DAMeegeggRITISTRREGDYVVISVRDNGPG 301
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1452482242 403 IDEGVLAewnespggKVL-------PSSYGNGYGLYICQEIMNKQGGSMRIESSEEMGTTIFITF 460
Cdd:COG4191 302 IPPEVLE--------RIFepffttkPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
79-465 |
3.16e-25 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 108.01 E-value: 3.16e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 79 KRMDVRVQMIGKNGDVVADTQ---KGALLHRNIDIESSLKGK---KSYVFEEGDPAPILLF-SSPVYYGNDVIGSV---- 147
Cdd:PRK11100 89 TRVDYRVYVTDAQGIVLFDSEgraVGQDYSRWNDVYLTLRGEygaRSTREDPADPESSVMYvAAPIRDGGRIIGVLsvgk 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 148 ------RFINEltGEKEVLtNVGWTFLMTSLclvAAGIFFAIRLARSLHKpidqLRQMAQRLANGDyksKIELNEY--VE 219
Cdd:PRK11100 169 pnssmaPFIKR--SERRIL-WAGALLLGIAL---LIGAGVVWWLNRSIRR----LTRYADAVTEGK---PVPLPKLgsSE 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 220 IAQLSASFNAMADgielhikQLkEEKEKQKDFLDRITHELKTPLTAIIGYVDLIPKLKAKEDVQESLRYVAVESERLLSL 299
Cdd:PRK11100 236 LRELAQALESMRV-------KL-EGKAYVEQYVQTLTHELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQL 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 300 VEELLKSSKYGTSTFEVSPTVVDIKELAEEAVSIVKPRLQQFEIEVINELTDVHVLADFDKTKQIFLNVLDNTIKYS-DA 378
Cdd:PRK11100 308 IDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSpEG 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 379 TQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAEWNE-------SPGGKvlPSSygnGYGLYICQEIMNKQGGSMRIESSEE 451
Cdd:PRK11100 388 GTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFErfyslprPANGR--KST---GLGLAFVREVARLHGGEVTLRNRPE 462
|
410
....*....|....
gi 1452482242 452 MGTTifITFLLPKR 465
Cdd:PRK11100 463 GGVL--ATLTLPRH 474
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
257-463 |
5.97e-24 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 102.62 E-value: 5.97e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 257 HELKTPLTAIIGYVDLIPKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKYGtstfEVSPTVVDIKELAEEAVSIVKP 336
Cdd:COG3852 144 HEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPR----PPEREPVNLHEVLERVLELLRA 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 337 RLQQfEIEVINELTD--VHVLADFDKTKQIFLNVLDN-----------TIKYSDATQIRMNVIVSEHEAKVFVHDDGIGI 403
Cdd:COG3852 220 EAPK-NIRIVRDYDPslPEVLGDPDQLIQVLLNLVRNaaeampeggtiTIRTRVERQVTLGGLRPRLYVRIEVIDNGPGI 298
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1452482242 404 DEGVL-----------AEwnespggkvlpssyGNGYGLYICQEIMNKQGGSMRIESSEEMGTTIFItfLLP 463
Cdd:COG3852 299 PEEILdrifepffttkEK--------------GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRI--YLP 353
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
169-454 |
1.61e-20 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 94.97 E-value: 1.61e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 169 MTSLCLVAAGIFFairlaRSLHKPIDQLRQMAQRLANGDYKSKIE----LNEYVEIAQLSASFNA-----------MADG 233
Cdd:PRK11466 341 LCALILILWRVVY-----RSVTRPLAEQTQALQRLLDGDIDSPFPetagVRELDTIGRLMDAFRSnvhalnrhreqLAAQ 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 234 I-----ELHI-----KQLKEEKEK----QKDFLDRITHELKTPLTAIIGYVDLIPKLKAKEDVQESLRYVAVESERLLSL 299
Cdd:PRK11466 416 VkartaELQElviehRQARAEAEKasqaKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTI 495
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 300 VEELLKSS--KYGTSTFEVSPTVVDIKELAEEAVSIVKPRLQQFEIEVINELTDV---HVLADFDKTKQIFLNVLDNTIK 374
Cdd:PRK11466 496 LNDILDYSaiEAGGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDlptALMGDPRRIRQVITNLLSNALR 575
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 375 YSDATQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAEWNEsPGGKVLPSSYGNGYGLYICQEIMNKQGGSMRIESSEEMGT 454
Cdd:PRK11466 576 FTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQ-PFVQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGS 654
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
170-462 |
5.60e-20 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 92.39 E-value: 5.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 170 TSLCLVAAGIFFAIR----LARSLHKPIDQLRQMAQRLANGDYKSKIELNEYVEIAQLSASFNAMADGIElhikqlKEEK 245
Cdd:PRK10549 165 TSWLIVALSTLLAALatflLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLE------KNEQ 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 246 EKqKDFLDRITHELKTPLTAIIGyvdlipKLKAKED-----VQESLRYVAVESERLLSLVEEL--LKSSKYGTSTFEVSP 318
Cdd:PRK10549 239 MR-RDFMADISHELRTPLAVLRG------ELEAIQDgvrkfTPESVASLQAEVGTLTKLVDDLhqLSLSDEGALAYRKTP 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 319 tvVDIKELAEEAVSIVKPRLQQFEIEVINELTD-VHVLADFDKTKQIFLNVLDNTIKYSDAtQIRMNVIVSEHEAKVFVH 397
Cdd:PRK10549 312 --VDLVPLLEVAGGAFRERFASRGLTLQLSLPDsATVFGDPDRLMQLFNNLLENSLRYTDS-GGSLHISAEQRDKTLRLT 388
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1452482242 398 --DDGIGIDEGVLAEW------NESPGGKvlpSSYGNGYGLYICQEIMNKQGGSMRIESSEEMGTTIFITFLL 462
Cdd:PRK10549 389 faDSAPGVSDEQLQKLferfyrTEGSRNR---ASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 458
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
192-460 |
1.13e-19 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 91.57 E-value: 1.13e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 192 PIDQLRQMAQRLANGDYKSKIELNEYV------EIAQLSASFNAMADGIELHI-----------KQLKEEKEKQkDFLDR 254
Cdd:COG5809 191 HSDDQENVAAFISQLLKDGGIAQGEVRfwtkdgRWRLLEASGAPIKKNGEVDGiviifrditerKKLEELLRKS-EKLSV 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 255 -------ITHELKTPLTAIIGYVDLipkLKAKEDVQESlRYVAV---ESERLLSLVEELLKSSKYGtstfEVSPTVVDIK 324
Cdd:COG5809 270 vgelaagIAHEIRNPLTSLKGFIQL---LKDTIDEEQK-TYLDImlsELDRIESIISEFLVLAKPQ----AIKYEPKDLN 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 325 ELAEEAVSIVKPR--LQQFEIEVINELTDVHVLADFDKTKQIFLNVLDNTIKysdATQIRMNVIVSEH---EAKVF--VH 397
Cdd:COG5809 342 TLIEEVIPLLQPQalLKNVQIELELEDDIPDILGDENQLKQVFINLLKNAIE---AMPEGGNITIETKaedDDKVVisVT 418
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1452482242 398 DDGIGIDEGVLAEWNEspggkvlP----SSYGNGYGLYICQEIMNKQGGSMRIESSEEMGTTIFITF 460
Cdd:COG5809 419 DEGCGIPEERLKKLGE-------PfyttKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
255-468 |
5.08e-19 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 90.03 E-value: 5.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 255 ITHELKTPLTAIIGYVDLIPKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKygtsTFEVSPTVVDIKELAEEAVSIV 334
Cdd:PRK11360 397 VAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSR----PRESQWQPVSLNALVEEVLQLF 472
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 335 KPRLQQ----FEIEVINELTDvhVLADFDKTKQIFLNVLDNTIKysdATQIRMNVIVSEHEAK-----VFVHDDGIGIDE 405
Cdd:PRK11360 473 QTAGVQarvdFETELDNELPP--IWADPELLKQVLLNILINAVQ---AISARGKIRIRTWQYSdgqvaVSIEDNGCGIDP 547
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1452482242 406 GVLAEWNEsPGGKVLPSsyGNGYGLYICQEIMNKQGGSMRIESSEEMGTTifITFLLPKRMED 468
Cdd:PRK11360 548 ELLKKIFD-PFFTTKAK--GTGLGLALSQRIINAHGGDIEVESEPGVGTT--FTLYLPINPQG 605
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
356-465 |
9.42e-18 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 78.84 E-value: 9.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 356 ADFDKTKQIFLNVLDNTIKYSDA-TQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAEWNEsPGGKVLPSSY---GNGYGLY 431
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEgGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFE-PFFRTDKRSRkigGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|....
gi 1452482242 432 ICQEIMNKQGGSMRIESSEEMGTTifITFLLPKR 465
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTT--FTITLPLE 111
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
255-463 |
4.82e-17 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 83.24 E-value: 4.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 255 ITHELKTPLTAIIGYVDLipkLKAKEDVQES-LRYVAVESERLLSLVEELLKSSKYGTSTFEVsptvVDIKELAEEAVSI 333
Cdd:COG5805 294 IAHEIRNPLTSIKGFLQL---LQPGIEDKEEyFDIMLSELDRIESIISEFLALAKPQAVNKEK----ENINELIQDVVTL 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 334 VKP--RLQQFEIEVINELTDVHVLADFDKTKQIFLNVLDNTIK-YSDATQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAE 410
Cdd:COG5805 367 LETeaILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEaMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKK 446
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1452482242 411 WNEspggkvlP----SSYGNGYGLYICQEIMNKQGGSMRIESSEEMGTTIFITFLLP 463
Cdd:COG5805 447 LGE-------PffttKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
356-464 |
6.67e-17 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 76.25 E-value: 6.67e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 356 ADFDKTKQIFLNVLDNTIKYS-DATQIRmnVIVSEHEAKVF-VHDDGIGIDEGVLAEWNESPGGKVLPSSYGNGYGLYIC 433
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAaKAGEIT--VTLSEGGELTLtVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLGLSIV 78
|
90 100 110
....*....|....*....|....*....|.
gi 1452482242 434 QEIMNKQGGSMRIESSEEMGTTIFITFLLPK 464
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
160-467 |
1.80e-16 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 81.60 E-value: 1.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 160 LTNVGWTFLMTSLCLVAAGIFFAIRLARSLHKPIDQLRQMAQRLANGDYKsKIELNEYVEIAQLSASFNAMADGIELHIK 239
Cdd:COG2972 152 LFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLV-RLEVSGNDEIGILARSFNEMVERIKELIE 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 240 QLKEEKEKQKDFldrithELKT------P------LTAIIGYVDLIPKLKAKEDVQ---ESLRYVAVESERLLSLVEELl 304
Cdd:COG2972 231 EVYELELEKKEA------ELKAlqaqinPhflfntLNSIRWLAELEDPEEAEEMLEalsKLLRYSLSKGDELVTLEEEL- 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 305 ksskygtstfevsptvvdikELAEEAVSIVKPRLQ---QFEIEVINELTDVHVLadfdktKQIFLNVLDNTIKYS----- 376
Cdd:COG2972 304 --------------------ELIKSYLEIQKLRFGdrlEVEIEIDEELLDLLIP------KLILQPLVENAIEHGiepke 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 377 DATQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAEWNESPGGKvlpsSYGNGYGLYICQEIMNKQ---GGSMRIESSEEMG 453
Cdd:COG2972 358 GGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSK----GEGRGIGLRNVRERLKLYygeEYGLEIESEPGEG 433
|
330
....*....|....
gi 1452482242 454 TTifITFLLPKRME 467
Cdd:COG2972 434 TT--VTIRIPLEEE 445
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
230-463 |
6.64e-16 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 79.22 E-value: 6.64e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 230 MADGIeLHIKQLKEEKEKQKDFLDRI----THELKTPLTAI--------IGYVDLIPKLKAK--EDVQESLRYVAVESER 295
Cdd:PRK09303 130 LSDEL-FVLRQENETLLEQLKFKDRVlamlAHDLRTPLTAAslaletleLGQIDEDTELKPAliEQLQDQARRQLEEIER 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 296 LlslVEELLKSSKYGTSTFEVSPTVVDIKELAEEAVSIVKPRL----QQFEIEVINELTDVHvlADFDKTKQIFLNVLDN 371
Cdd:PRK09303 209 L---ITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWlaksLEIQTDIPSDLPSVY--ADQERIRQVLLNLLDN 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 372 TIKYS-DATQIRMNVIvseH----EAKVFVHDDGIGIDEgvlAEWNESPGGKV-LPSSY---GNGYGLYICQEIMNKQGG 442
Cdd:PRK09303 284 AIKYTpEGGTITLSML---HrttqKVQVSICDTGPGIPE---EEQERIFEDRVrLPRDEgteGYGIGLSVCRRIVRVHYG 357
|
250 260
....*....|....*....|.
gi 1452482242 443 SMRIESSEEMGTTiFiTFLLP 463
Cdd:PRK09303 358 QIWVDSEPGQGSC-F-HFTLP 376
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
175-463 |
4.56e-15 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 76.95 E-value: 4.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 175 VAAGIFFAIRLA-------RSLHKPIDQLRQMAQRLANGDYKSKIELNEYVEIAQLSASFNAMADGIELHI---KQLkee 244
Cdd:PRK10604 139 IALLALIGLSLAfpvflwmRPHWQDMLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIaskKQL--- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 245 kekqkdfLDRITHELKTPLtaiigyVDLIPKLKAKEDVQESLRyVAVESE--RLLSLVEELLKSSKYGTSTFEVSPTVVD 322
Cdd:PRK10604 216 -------IDGIAHELRTPL------VRLRYRLEMSDNLSAAES-QALNRDigQLEALIEELLTYARLDRPQNELHLSEPD 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 323 IKELAEEAVSIVKPRLQQFEIEVINELTDVHVLADFDKTKQIFLNVLDNTIKYSDaTQIRMNVIVSEHEAKVFVHDDGIG 402
Cdd:PRK10604 282 LPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAH-SRVRVSLLLDGNQACLIVEDDGPG 360
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1452482242 403 IDEGvLAEWNESPGGKVLPS----SYGNGYGLYICQEIMNKQGGSMRIESSeEMGTTIFiTFLLP 463
Cdd:PRK10604 361 IPPE-ERERVFEPFVRLDPSrdraTGGCGLGLAIVHSIALAMGGSVNCDES-ELGGARF-SFSWP 422
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
248-476 |
1.37e-14 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 76.70 E-value: 1.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 248 QKDFLDRITHELKTPLTAIIGYVDLIPKLK-AKEDVQESLRYVAVESERLLSLVEELLKSSKYGTSTFEVSPTVVDIKEL 326
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGlSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTL 791
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 327 AEE------AVSIVKprlqQFEIEVINELTDvHVLADFDKT--KQIFLNVLDNTIKYSDATQIRMN---VIVSEHEA--K 393
Cdd:PRK09959 792 VQNtchsfgAIAASK----SIALSCSSTFPD-HYLVKIDPQafKQVLSNLLSNALKFTTEGAVKITtslGHIDDNHAviK 866
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 394 VFVHDDGIGIDE----GVLAEWNESPGGKvlpSSYGNGYGLYICQEIMNKQGGSMRIESSEEMGTTIFITflLPkrMEDI 469
Cdd:PRK09959 867 MTIMDSGSGLSQeeqqQLFKRYSQTSAGR---QQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTIT--IP--VEIS 939
|
....*..
gi 1452482242 470 KNLKAVK 476
Cdd:PRK09959 940 QQVATVE 946
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
18-458 |
5.56e-14 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 73.58 E-value: 5.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 18 IFVLLYAVVYITLEKNMYHNAANSLEKLSVE--AQIYTM--NYLEKEAEV------------ETLGPNSLLIASYLAKRM 81
Cdd:TIGR01386 11 LFAAVTALVFALSGFMLYSSLERHFEERDREelQGKLEQvrRFLRDPADLdedikrlqekidDLLVGHSDLALSILNPDG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 82 DVRVQMIGKNGDVVADTQKGALLHRNIDIESSlkGKKSYVFEEGDPAPILLFSSPVYYgndVIGSvrfinELTGEKEVLT 161
Cdd:TIGR01386 91 RLLFERAQGAALVPAVAANDALLELDQADAKM--THYRSILRSVAALPGGKGRKPVQI---TVAL-----DINAHTHLLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 162 NVGWTFLMTSLCLVAAGIFFAIRLARSLHKPIDQLRQMAQRLANGDYKSKI-ELNEYVEIAQLSASFNAMadgielhIKQ 240
Cdd:TIGR01386 161 ALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLdPSRAPAELRELAQSFNAM-------LGR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 241 LKEEKEKQKDFLDRITHELKTPLTAIIGYVD-LIPKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKYGTSTFEVSPT 319
Cdd:TIGR01386 234 LEDAFQRLSQFSADLAHELRTPLTNLLGQTQvALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 320 VVDikeLAEEAvsivkPRLQQFeIEVINELTDV--------HVLADFDKTKQIFLNVLDNTIKYS-DATQIRMNVIVSEH 390
Cdd:TIGR01386 314 RLD---LAAEL-----AKVAEY-FEPLAEERGVrirvegegLVRGDPQMFRRAISNLLSNALRHTpDGGTITVRIERRSD 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 391 EAKVFVHDDGIGIDEGVL------------AEWNespggkvlpSSYGNGYGLYICQEIMNKQGGSMRIESSEemGTTIFI 458
Cdd:TIGR01386 385 EVRVSVSNPGPGIPPEHLsrlfdrfyrvdpARSN---------SGEGTGLGLAIVRSIMEAHGGRASAESPD--GKTRFI 453
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
156-460 |
1.28e-12 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 70.10 E-value: 1.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 156 EKEVLTNVGWTFLMTSLCLVAAGIFFAIRLARSLHKPIDQLRQMAQRLANGDYKSKIELNEYVEIAQLSAS-----FNA- 229
Cdd:COG4192 318 AQLVQQSGILLLAIALLSLLLAVLINYFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLlrvfrDQAi 397
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 230 -----MADGIELHIKQLKEEKEKQKDFLD------------RITHELKTPLTAIIGYVDLIPKLKAKEDvQESLRYVAVE 292
Cdd:COG4192 398 ektqeLETEIEERKRIEKNLRQTQDELIQaakmavvgqtmtSLAHELNQPLNAMSMYLFSAKKALEQEN-YAQLPTSLDK 476
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 293 SERLLSLVEELLKSSKYGTSTFEVSPTVVDIKELAEEAVSIVKPRLQQFEIeVINELTDVHVLADFDKTKQIFLNVLDNT 372
Cdd:COG4192 477 IEGLIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWELVESRAKPQQI-TLHIPDDLMVQGDQVLLEQVLVNLLVNA 555
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 373 IKYS-DATQIRMNVIVSEHEAKVFVHDDGIGIDegvLAEWNESPggKVLPSSYGNGYGLYICQEIMNKQGGSMRIESSEE 451
Cdd:COG4192 556 LDAVaTQPQISVDLLSNAENLRVAISDNGNGWP---LVDKLFTP--FTTTKEVGLGLGLSICRSIMQQFGGDLYLASTLE 630
|
....*....
gi 1452482242 452 MGTTIFITF 460
Cdd:COG4192 631 RGAMVILEF 639
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
247-304 |
2.38e-12 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 61.84 E-value: 2.38e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1452482242 247 KQKDFLDRITHELKTPLTAIIGYVDLIPKLKAKEDVQESLRYVAVESERLLSLVEELL 304
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLL 58
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
246-308 |
3.59e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 61.46 E-value: 3.59e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1452482242 246 EKQKDFLDRITHELKTPLTAIIGYVDLIP-KLKAKEDVQESLRYVAVESERLLSLVEELLKSSK 308
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEeELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
11-410 |
6.61e-12 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 67.83 E-value: 6.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 11 IVGLLIPIFVLLYAVVYITLEKNMYHNAANSLEKLSVEAQIYTMNYLEKEAEVETLGPNSLLIASYLAKRMDVRVQMIGK 90
Cdd:COG2770 58 LLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLA 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 91 NGDVVADTQKGALLHRNIDIESSLKGKKSYVFEEGDPAPILLFSSPVYYGNDVIGSVRFINELTGEKEVLTNVGWTFLMT 170
Cdd:COG2770 138 LALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLL 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 171 SLCLVAAGIFFAIRLARSLHKPIDQLRQMAQRLANGDYKSKIELNEYVEIAQLSASFNAMADGIELHIKQLKEEKEKQKD 250
Cdd:COG2770 218 ALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEA 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 251 FLDRITHELKTPLTAIIGYVDLIPKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKYGTSTFEVSPTVVDIKELAEEA 330
Cdd:COG2770 298 ELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLL 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 331 VSIVKPRLQQFEIEVINELTDVHVLADFDKTKQIFLNVLDNTIKYSDATQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAE 410
Cdd:COG2770 378 ALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGL 457
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
251-458 |
1.27e-11 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 66.92 E-value: 1.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 251 FLDRITHELKTPLTAIIGYVDLipkLKAKEDVQESLRYVAV---ESERLLSLVEELLKSSKYGTSTFEVSPTVVDIKELA 327
Cdd:PRK10841 450 FLATVSHELRTPLYGIIGNLDL---LQTKELPKGVDRLVTAmnnSSSLLLKIISDILDFSKIESEQLKIEPREFSPREVI 526
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 328 EEAVS-----IVKPRLQQF-EIEvinelTDVHVLADFD--KTKQIFLNVLDNTIKYSDATQIRMNVIVSEHEAKVFVHDD 399
Cdd:PRK10841 527 NHITAnylplVVKKRLGLYcFIE-----PDVPVALNGDpmRLQQVISNLLSNAIKFTDTGCIVLHVRVDGDYLSFRVRDT 601
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1452482242 400 GIGIDEGVLAEWNEsP----GGKVLPSSYGNGYGLYICQEIMNKQGGSMRIESSEEMGtTIFI 458
Cdd:PRK10841 602 GVGIPAKEVVRLFD-PffqvGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMG-SQFT 662
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
363-463 |
1.59e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 60.80 E-value: 1.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 363 QIFLNVLDNTIKYS---DATQIRMNVIVSEHEAKVFVHDDGIGIDEgvlaEWNEspggKV--------LPSSY-GNGYGL 430
Cdd:cd16921 3 QVLTNLLGNAIKFRrprRPPRIEVGAEDVGEEWTFYVRDNGIGIDP----EYAE----KVfgifqrlhSREEYeGTGVGL 74
|
90 100 110
....*....|....*....|....*....|...
gi 1452482242 431 YICQEIMNKQGGSMRIESSEEMGTTIFITflLP 463
Cdd:cd16921 75 AIVRKIIERHGGRIWLESEPGEGTTFYFT--LP 105
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
165-389 |
2.87e-11 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 65.29 E-value: 2.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 165 WTFLMTSLCLVAAGIFFAIRLARSLHKPIDQLRQMAQRLANGDYKSKIELNEYVEIAQLSASFNAMADGIELHIKQLKEE 244
Cdd:COG3850 118 KLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEE 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 245 KEKQKDFLDRITHELKTPLTAIIGYVDLIPKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKYGTSTFEVSPTVVDIK 324
Cdd:COG3850 198 EELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASA 277
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1452482242 325 ELAEEAVSIVKPRLQQFEIEVINELTDVHVLADFDKTKQIFLNVLDNTIKYSDATQIRMNVIVSE 389
Cdd:COG3850 278 LLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLE 342
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
238-466 |
3.39e-11 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 65.03 E-value: 3.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 238 IKQLKEEKEKQKDFLDRITHELKTPLTAIIGYVDLI--PKL------KAKEDVQESLRyvaveseRLLSLVEELLKSSKy 309
Cdd:PRK11006 194 VTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMqdQPLegalreKALHTMREQTQ-------RMEGLVKQLLTLSK- 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 310 gtstFEVSPT-----VVDI----KELAEEAVSIVKPRlQQFEIEVINELtdvHVLADFDKTKQIFLNVLDNTIKYS-DAT 379
Cdd:PRK11006 266 ----IEAAPTidlneKVDVpmmlRVLEREAQTLSQGK-HTITFEVDNSL---KVFGNEDQLRSAISNLVYNAVNHTpEGT 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 380 QIRMNVIVSEHEAKVFVHDDGIGIDEGVLAEWNE-----------SPGgkvlpssyGNGYGLYICQEIMNKQGGSMRIES 448
Cdd:PRK11006 338 HITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTErfyrvdkarsrQTG--------GSGLGLAIVKHALSHHDSRLEIES 409
|
250
....*....|....*...
gi 1452482242 449 SEEMGTTifITFLLPKRM 466
Cdd:PRK11006 410 EVGKGTR--FSFVLPERL 425
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
238-467 |
3.78e-11 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 64.48 E-value: 3.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 238 IKQLKEEKEKQKDFLD---RITHELKTPLTAIIGYVDLipklkakEDVQESLRYVAVESERLLSLVEELLKSSKygtstf 314
Cdd:COG3290 176 LERLEEELEGVKELAEalrAQRHDFRNHLHTISGLLQL-------GEYDEALEYIDEISEELQELIDSLLSRIG------ 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 315 evsPTVVD------IKELAEEAVsivkprlqQFEIEVINELTDVHvLADFDKTKqIFLNVLDNTIkysDATQ-------- 380
Cdd:COG3290 243 ---NPVLAalllgkAARARERGI--------DLTIDIDSDLPDLP-LSDTDLVT-ILGNLLDNAI---EAVEklpeeerr 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 381 IRMNVIVSEHEAKVFVHDDGIGIDEGVLAEWNE----SPGGKvlpssyGNGYGLYICQEIMNKQGGSMRIESSEEMGTTI 456
Cdd:COG3290 307 VELSIRDDGDELVIEVEDSGPGIPEELLEKIFErgfsTKLGE------GRGLGLALVKQIVEKYGGTIEVESEEGEGTVF 380
|
250
....*....|.
gi 1452482242 457 FITflLPKRME 467
Cdd:COG3290 381 TVR--LPKEGE 389
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
247-308 |
8.27e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 57.58 E-value: 8.27e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1452482242 247 KQKDFLDRITHELKTPLTAIIGYVDLIPKLKAKEDVQESLRYVAVESERLLSLVEELLKSSK 308
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSR 62
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
179-463 |
1.02e-10 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 63.39 E-value: 1.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 179 IFFAIRLARSLHKPIDQLRQMAQRLANGDYKSKIELNEYVEIAQLSASFNAMADGielhIKQLKEekekqkdflDR---- 254
Cdd:PRK09467 167 VAGGWLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAG----IKQLED---------DRtllm 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 255 --ITHELKTPLTAIigyvdlipKLkAKEDVQESLRYVAvES-----ERLLSLVEELLKSSKYGTstfEVSPTVVDIKELA 327
Cdd:PRK09467 234 agVSHDLRTPLTRI--------RL-ATEMMSEEDGYLA-ESinkdiEECNAIIEQFIDYLRTGQ---EMPMEMADLNALL 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 328 EEAVSIVKPRLQQFEIEVINELTDV--HVLAdfdkTKQIFLNVLDNTIKYSDAtQIRMNVIVSEHEAKVFVHDDGIGIDE 405
Cdd:PRK09467 301 GEVIAAESGYEREIETALQPGPIEVpmNPIA----IKRALANLVVNAARYGNG-WIKVSSGTEGKRAWFQVEDDGPGIPP 375
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 406 GVLAEWNEsP--GGKVLPSSYGNGYGLYICQEIMNKQGGSMRIESSEEMGTTIFITFLLP 463
Cdd:PRK09467 376 EQLKHLFQ-PftRGDSARGSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLT 434
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
239-463 |
1.25e-10 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 63.89 E-value: 1.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 239 KQLKEEKEKQK-DFLDRITHELKTPLTAIIGYVDLI--PKLKAKedvQESLRYVAVESER-LLSLVEELLKSSKYGTSTF 314
Cdd:PRK15347 388 KQRAEQANKRKsEHLTTISHEIRTPLNGVLGALELLqnTPLTAE---QMDLADTARQCTLsLLAIINNLLDFSRIESGQM 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 315 EVSPTVVDIKELAEEAVSIVKPRLQQFEIEVINELT-DVHVLADFD--KTKQIFLNVLDNTIKYSDATQIRMNVIVSEHE 391
Cdd:PRK15347 465 TLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGaHVPLYLHLDslRLRQILVNLLGNAVKFTETGGIRLRVKRHEQQ 544
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1452482242 392 AKVFVHDDGIGIDEgvlAEWNE--SPGGKVLPSSYGNGYGLYICQEIMNKQGGSMRIESSEEMGTTifITFLLP 463
Cdd:PRK15347 545 LCFTVEDTGCGIDI---QQQQQifTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSC--FSLVLP 613
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
362-462 |
1.91e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 57.89 E-value: 1.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 362 KQIFLNVLDNTIKYSDATQIRMNVIVSEHEA-----KVFVHDDGIGIDEGVLA---EWNESPGGKVLPSSYGNGYGLYIC 433
Cdd:cd16922 2 RQILLNLLGNAIKFTEEGEVTLRVSLEEEEEdgvqlRFSVEDTGIGIPEEQQArlfEPFSQADSSTTRKYGGTGLGLAIS 81
|
90 100
....*....|....*....|....*....
gi 1452482242 434 QEIMNKQGGSMRIESSEEMGTTIFITFLL 462
Cdd:cd16922 82 KKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
255-461 |
2.52e-10 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 62.50 E-value: 2.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 255 ITHELKTPLTAIIGYVDLI-PKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKYGtstfEVSPTVVDIKELAEEAVSI 333
Cdd:PRK10364 244 VAHEIRNPLSSIKGLAKYFaERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKPT----HLALQAVDLNDLINHSLQL 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 334 VKPRLQQFEIEV---INElTDVHVLADFDKTKQIFLNVLDNTIKYSDaTQIRMNVIVSEHEA--KVFVHDDGIGID---- 404
Cdd:PRK10364 320 VSQDANSREIQLrftAND-TLPEIQADPDRLTQVLLNLYLNAIQAIG-QHGVISVTASESGAgvKISVTDSGKGIAadql 397
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1452482242 405 EGVLAEWNESPGGkvlpssyGNGYGLYICQEIMNKQGGSMRIESSEEMGtTIFITFL 461
Cdd:PRK10364 398 EAIFTPYFTTKAE-------GTGLGLAVVHNIVEQHGGTIQVASQEGKG-ATFTLWL 446
|
|
| HAMP |
pfam00672 |
HAMP domain; |
184-235 |
3.14e-10 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 55.32 E-value: 3.14e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1452482242 184 RLARSLHKPIDQLRQMAQRLANGDYKSKIELNEYVEIAQLSASFNAMADGIE 235
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLR 52
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
11-458 |
4.57e-10 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 61.40 E-value: 4.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 11 IVGLLIPIFVLLYAVVYITLEknmyHNAANSLEKLSVEAQIYTMNYLEKEAEvetlGPNSLLIASYLAKRMDVRVQMIGK 90
Cdd:NF038389 7 ITILFAIALVSVSALFLILLK----YQKENYNEELNKKYSLIANTLLQLYQK----NINEEELEKYLKNFGFMPITDKKL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 91 NGDVVADTQKGALLHRNIDIESSLKGKKSYVFEEGDPAPILLFSS--PVYYGNDVIGSVRFINeltgekevltnvgwtFL 168
Cdd:NF038389 79 EKEILEIGKNKFILKENGSFRILKYNDKIYLLIKNDGFSLLLEDNekKSYRYYYIIVFFIFLI---------------LL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 169 MTSLclvaagiFFAIRlaRSLhKPIDQLRQMAQRLANGD-YKSKIELNeYVEIAQLSASFNAMadgielhIKQLKEEKEK 247
Cdd:NF038389 144 LLIL-------YISVL--KSL-KPLKKLKKQIKKFANGDfDFIKSESN-GDEIGEVANEFDKA-------VKKIKALNES 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 248 QKDFLDRITHELKTPLTAIIGYVDLIPKLKAKEdvqeslRYVAVeSERLLSLVEELLKSSKYGTSTFEVSPTVVDIKELA 327
Cdd:NF038389 206 RQLFLRNIMHELKTPITKGRIVAEMLEDEKQKE------RLISI-FERLESLINEFAKIEQLTSKNYKLNKKEYRLSDII 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 328 EEAVSIVKPRLQQFEIEVINEltDVHVLADFDKTKQIFLNVLDNTIKYSDatqirmnvivsEHEAKVFVHDDGIGIdegv 407
Cdd:NF038389 279 DEAIDMLMIDDSSVIIKVSLE--DFKLNVDFELFSLAIKNLIDNAIKYSP-----------DKKVTIEIKGDKIEF---- 341
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1452482242 408 laewnESPGGK---------------VLPSSYGNGYGLYICQEIMNKQGgsMRIESSEEMGTTIFI 458
Cdd:NF038389 342 -----KNKGEPleepleyyfepffkgNEKSKSGFGLGLYIVKNILKAHG--FKLEYEYENGYNIFI 400
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
163-460 |
6.56e-10 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 59.63 E-value: 6.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 163 VGWTFLMTSLCLVAAGIFFAIRLARSLHKPIDQLRQMAQRLANgdyksKIELNEYVEIAQLSAsfnamadgiELHikqlk 242
Cdd:COG4585 2 LALALLGALALLVGALLGLLLALVLLRARRAERAAELERELAA-----RAEEAREEERRRIAR---------ELH----- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 243 eekekqkdflDRITHELktplTAIIGYVDLIPKLKAK--EDVQESLRYVAVESERLLSLVEELLKSskYGTSTFEVSPTV 320
Cdd:COG4585 63 ----------DGVGQSL----SAIKLQLEAARRLLDAdpEAAREELEEIRELAREALAELRRLVRG--LRPPALDDLGLA 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 321 VDIKELAEEAvsivkPRLQQFEIEVINELTDVHVLADFDKTkqIFLNV---LDNTIKYSDATQIRMNVIVSEHEAKVFVH 397
Cdd:COG4585 127 AALEELAERL-----LRAAGIRVELDVDGDPDRLPPEVELA--LYRIVqeaLTNALKHAGATRVTVTLEVDDGELTLTVR 199
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1452482242 398 DDGIGIDEGVLAewnespggkvlpssyGNGYGLYICQEIMNKQGGSMRIESSEEMGTTIFITF 460
Cdd:COG4585 200 DDGVGFDPEAAP---------------GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
185-405 |
8.88e-10 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 60.72 E-value: 8.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 185 LARSLHKPIDQLRQMAQRLANGDYKSKIELNEYV-EIAQLSASFNAMADGIELHIkqlkeekEKQKDFLDRITHELKTPL 263
Cdd:PRK09470 186 LAWSLAKPARKLKNAADEVAQGNLRQHPELETGPqEFRQAGASFNQMVTALERMM-------TSQQRLLSDISHELRTPL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 264 TAIIGYVDLipklkAKEDVQES--LRYVAVESERLLSLVEELLKSSKYGTSTfEVSPTVVDIKELAEEavsIVKPrlQQF 341
Cdd:PRK09470 259 TRLQLATAL-----LRRRQGESkeLERIETEAQRLDSMINDLLVLSRNQQKN-HLERETFKANSLWSE---VLED--AKF 327
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1452482242 342 EIEVINEltDVHVLADfdkTKQIFL------------NVLDNTIKYSDaTQIRMNVIVSEHEAKVFVHDDGIGIDE 405
Cdd:PRK09470 328 EAEQMGK--SLTVSAP---PGPWPIngnpnalasaleNIVRNALRYSH-TKIEVAFSVDKDGLTITVDDDGPGVPE 397
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
191-234 |
1.18e-09 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 53.60 E-value: 1.18e-09
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1452482242 191 KPIDQLRQMAQRLANGDYKSKIELNEYVEIAQLSASFNAMADGI 234
Cdd:cd06225 2 RPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
187-238 |
1.68e-08 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 50.71 E-value: 1.68e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1452482242 187 RSLHKPIDQLRQMAQRLANGDYKSKIELNEYVEIAQLSASFNAMADGIELHI 238
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETI 52
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
257-447 |
1.15e-07 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 53.88 E-value: 1.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 257 HELKTPLTAiigyvdlipkLKAKEDV------QESLRYVAVES-----ERLLSLVEELLKSSKY--GTSTFEVSPtvVDI 323
Cdd:PRK10337 246 HELRSPLAA----------LKVQTEVaqlsddDPQARKKALLQlhagiDRATRLVDQLLTLSRLdsLDNLQDVAE--IPL 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 324 KELAEEAVSIVKPRLQQFEIEVINELTDVHVLadfdKTKQIFL------NVLDNTIKYSDATQIrMNVIVSEHEAKvfVH 397
Cdd:PRK10337 314 EDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVI----RTGQPLLlsllvrNLLDNAIRYSPQGSV-VDVTLNARNFT--VR 386
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1452482242 398 DDGIGIDEGVLAEWNE---SPGGKvlpSSYGNGYGLYICQEIMNKQGgsMRIE 447
Cdd:PRK10337 387 DNGPGVTPEALARIGErfyRPPGQ---EATGSGLGLSIVRRIAKLHG--MNVS 434
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-463 |
1.29e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 49.73 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 362 KQIFLNVLDNTIKYSDAT-QIRMNVIVSEHEAKVFVHDDGIGIDEGVLAEWNEsPGGKVLPSSYGNGYGLYICQEIMNKQ 440
Cdd:cd16943 5 NQVLLNLLVNAAQAMEGRgRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFD-PFFTTKPVGEGTGLGLSLSYRIIQKH 83
|
90 100
....*....|....*....|...
gi 1452482242 441 GGSMRIESSEEMGTTifITFLLP 463
Cdd:cd16943 84 GGTIRVASVPGGGTR--FTIILP 104
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-460 |
2.92e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 49.00 E-value: 2.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 357 DFDKTKQIFLNVLDNTIKYSDAT-QIRMNVIVSEHEAKVFVHDDGIGIDEGVLAEWNES---PGGKVLPSSYGNGYGLYI 432
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGgKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERfyrVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*...
gi 1452482242 433 CQEIMNKQGGSMRIESSEEMGTTIFITF 460
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTL 108
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-460 |
3.62e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 49.17 E-value: 3.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 367 NVLDNTIKYSDAtQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAEWNESpGGKVLPSSYGNGYGLYICQEIMNKQGGSMRI 446
Cdd:cd16954 44 NLLDNACKWCLE-FVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQR-GQRLDEQRPGQGLGLAIAKEIVEQYGGELSL 121
|
90
....*....|....
gi 1452482242 447 ESSEEMGTTIFITF 460
Cdd:cd16954 122 SDSPLGGARFEVVF 135
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
174-243 |
5.18e-07 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 51.94 E-value: 5.18e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 174 LVAAGIFFAIRLARSLHKPIDQLRQMAQRLANGDYKSKIELNEYVEIAQLSASFNAMADGIELHIKQLKE 243
Cdd:COG0840 191 LVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRMIENLRELVGQVRE 260
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
352-460 |
6.20e-07 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 51.78 E-value: 6.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 352 VHVLadfdktkQIFLNVLDNTIKYSDATQIRMN-VIVSEHEAKVFVHDDGIGIDEgvlaewnespggkvlPSSYGNGYGL 430
Cdd:PRK10935 470 VHLL-------QIIREATLNAIKHANASEIAVScVTNPDGEHTVSIRDDGIGIGE---------------LKEPEGHYGL 527
|
90 100 110
....*....|....*....|....*....|
gi 1452482242 431 YICQEIMNKQGGSMRIESSEEMGTTIFITF 460
Cdd:PRK10935 528 NIMQERAERLGGTLTISQPPGGGTTVSLTF 557
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
369-460 |
7.53e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 46.78 E-value: 7.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 369 LDNTIKYSDATQIRMNVIVSEHEAKVFVHDDGIGIDEGvlaewNESPGGkvlpssygnGYGLYICQEIMNKQGGSMRIES 448
Cdd:cd16917 9 LTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGP-----APPGGG---------GFGLLGMRERAELLGGTLTIGS 74
|
90
....*....|..
gi 1452482242 449 SEEMGTTIFITF 460
Cdd:cd16917 75 RPGGGTRVTARL 86
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-459 |
1.03e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 47.51 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 341 FEIEVINELTDVHVLADFDKTKQIFLNVLDNTIKYSDATQIrMNVIVSEHEAKVF--VHDDGIGIDegvlaewnESPGGK 418
Cdd:cd16947 1 FQVEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKF-LGMTLREDEKHVYidIWDKGKGIS--------ETEKDH 71
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1452482242 419 VLPSSY-----------GNGYGLYICQEIMNKQGGSMRIESSEEMGTTIFIT 459
Cdd:cd16947 72 VFERLYtledsrnsakqGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVT 123
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
369-465 |
1.14e-06 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 50.75 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 369 LDNTIKYSDATQIRMNVIVSEHEAKVFVHDDGIGIDegvlaewnespggkvlPSSYGNGYGLYICQEIMNKQGGSMRIES 448
Cdd:PRK11644 419 LNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLP----------------PGSGQQGFGLRGMRERVTALGGTLTISC 482
|
90
....*....|....*..
gi 1452482242 449 SEemGTTIFITflLPKR 465
Cdd:PRK11644 483 TH--GTRLSVS--LPQR 495
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
219-455 |
6.01e-06 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 48.91 E-value: 6.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 219 EIAQLSASFNAMADGIElhIKQLKEEKEKQKDFLDR-------------ITHELKTPLTAIIGYVDL-IPKLKAKEDVQE 284
Cdd:PRK13837 410 ELQLLELALDCLAHAIE--RRRLETERDALERRLEHarrleavgtlasgIAHNFNNILGAILGYAEMaLNKLARHSRAAR 487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 285 SLRYVAVESERLLSLVEELLKSSKYGTSTfeVSPtvVDIKELAEEAVSIVKPRLQQ-FEIEVINELTDVHVLADFDKTKQ 363
Cdd:PRK13837 488 YIDEIISAGARARLIIDQILAFGRKGERN--TKP--FDLSELVTEIAPLLRVSLPPgVELDFDQDQEPAVVEGNPAELQQ 563
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 364 IFLNVLDNTIKYSDATQiRMNVIVSEHE-----------------AKVFVHDDGIGIDEGVLAEWNE-----SPGgkvlp 421
Cdd:PRK13837 564 VLMNLCSNAAQAMDGAG-RVDISLSRAKlrapkvlshgvlppgryVLLRVSDTGAGIDEAVLPHIFEpffttRAG----- 637
|
250 260 270
....*....|....*....|....*....|....
gi 1452482242 422 ssyGNGYGLYICQEIMNKQGGSMRIESSEEMGTT 455
Cdd:PRK13837 638 ---GTGLGLATVHGIVSAHAGYIDVQSTVGRGTR 668
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
236-454 |
7.32e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 48.78 E-value: 7.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 236 LHIKQLKEEKEKQ--KDFLDRITHELKTPLTAIIGYVDLIPKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKYGTST 313
Cdd:PRK10618 436 LQQAQREYEKNQQarKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQD 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 314 FEVSPTVVDIKELAEEAVSIVKPRLQQFEIEVINeltdvHVLADFDKT--------KQIFLNVLDNTIKYSDATQIRMNV 385
Cdd:PRK10618 516 WKPEQELFSLQDLIDEVLPEVLPAIKRKGLQLLI-----HNHLKAEQLrigdrdalRKILLLLLNYAITTTAYGKITLEV 590
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1452482242 386 IVSEHEAK--VF-VHDDGIGIDEGVLAEWNESPGGKVLPSSYGNGYGL--YICQEIMNKQGGSMRIESSEEMGT 454
Cdd:PRK10618 591 DQDESSPDrlTIrILDTGAGVSIKELDNLHFPFLNQTQGDRYGKASGLtfFLCNQLCRKLGGHLTIKSREGLGT 664
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-460 |
9.37e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 44.70 E-value: 9.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 348 ELTDVHVLADFDKTKQIFLNVLDNTIKYSDATQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAEWNES---PGGKVLPssy 424
Cdd:cd16940 1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERfyrSDGQNYG--- 77
|
90 100 110
....*....|....*....|....*....|....*.
gi 1452482242 425 GNGYGLYICQEIMNKQGGSMRIESSEEMGTTIFITF 460
Cdd:cd16940 78 GSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
365-465 |
1.66e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 43.73 E-value: 1.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 365 FLNVLDNTIKYS-DATQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAEWNE------SPGGKvlpSSYGNGYGLYICQEIM 437
Cdd:cd16952 5 FSNLVSNAVKYTpPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTErfyrvdIERCR---NTGGTGLGLAIVKHVM 81
|
90 100
....*....|....*....|....*...
gi 1452482242 438 NKQGGSMRIESSEEMGTTifITFLLPKR 465
Cdd:cd16952 82 SRHDARLLIASELGKGSR--FTCLFPSS 107
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-460 |
3.60e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 42.66 E-value: 3.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 364 IFLNVLDNTIKYSD-ATQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAE-----WNESPGGKVLPSSygnGYGLYICQEIM 437
Cdd:cd16948 9 IIGQIVSNALKYSKqGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRvfdkgFTGENGRNFQEST---GMGLYLVKKLC 85
|
90 100
....*....|....*....|...
gi 1452482242 438 NKQGGSMRIESSEEMGTTIFITF 460
Cdd:cd16948 86 DKLGHKIDVESEVGEGTTFTITF 108
|
|
| UhpB |
COG3851 |
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ... |
369-470 |
4.55e-05 |
|
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];
Pssm-ID: 443060 [Multi-domain] Cd Length: 493 Bit Score: 45.77 E-value: 4.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 369 LDNTIKYSDATQIRMNVIVSEHEAKVFVHDDGIGIDegvlaewnespggkvlPSSYGNGYGLYICQEIMNKQGGSMRIES 448
Cdd:COG3851 409 LTNILKHAEASQIRISLSQDKRLLSLEIRDDGIGLP----------------PELRAKGFGLRGMRERVRALGGDFRLSS 472
|
90 100
....*....|....*....|..
gi 1452482242 449 SEEmGTTIFITFLLPKRMEDIK 470
Cdd:COG3851 473 APK-GTRLSVLLPTPAASNEAG 493
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
168-466 |
4.99e-05 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 45.53 E-value: 4.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 168 LMTSLCLVAAGIFFAIRLA-RSLHKPIDQLRQMAQRLANGDYKSKIELNEY-VEIAQLSASFNAMADGIElhikqlkEEK 245
Cdd:PRK09835 187 LIMTASVISLLIVFIVLLAvHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVpIELEQLVLSFNHMIERIE-------DVF 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 246 EKQKDFLDRITHELKTPLTAIIGYVDL-IPKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKYGTSTFEVSPTVVDIK 324
Cdd:PRK09835 260 TRQSNFSADIAHEIRTPITNLITQTEIaLSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLA 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 325 ELAEEAVSIVKPRLQQFEIEVINELTDVHVLADFDKTKQIFLNVLDNTIKYSDATQiRMNVIVSE--HEAKVFVHDDGIG 402
Cdd:PRK09835 340 DEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGE-AITVRCQEvdHQVQLVVENPGTP 418
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1452482242 403 IDEGVLAEWNESpGGKVLPSSY----GNGYGLYICQEIMNKQGGSMRIESseEMGTTIFItFLLPKRM 466
Cdd:PRK09835 419 IAPEHLPRLFDR-FYRVDPSRQrkgeGSGIGLAIVKSIVVAHKGTVAVTS--DARGTRFV-ISLPRLE 482
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-463 |
6.27e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 42.00 E-value: 6.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 362 KQIFLNVLDNTIK-----YSDATQIRMNVIVSEHEA-KVFVHDDGIGIDEGVLAEWNESpggKVLPSSYGNGYGLYICQE 435
Cdd:cd16920 2 QQVLINLVRNGIEamsegGCERRELTIRTSPADDRAvTISVKDTGPGIAEEVAGQLFDP---FYTTKSEGLGMGLSICRS 78
|
90 100
....*....|....*....|....*...
gi 1452482242 436 IMNKQGGSMRIESSEEMGTTIFITflLP 463
Cdd:cd16920 79 IIEAHGGRLSVESPAGGGATFQFT--LP 104
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
249-461 |
7.86e-05 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 44.69 E-value: 7.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 249 KDFLDRITHELKTPLTAIIGYVDLIPKLKAKEDVQESLRYVAVESERLLSLVEELLKSSKYGTSTFE----VSPTVVDIK 324
Cdd:PRK11073 131 RDLVRGLAHEIKNPLGGLRGAAQLLSKALPDPALTEYTKVIIEQADRLRNLVDRLLGPQRPGTHVTEsihkVAERVVQLV 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 325 EL-AEEAVSIVK---PRLQQFEIevineltdvhvlaDFDKTKQIFLNVLDN------------TIKYSDATQIRMNVIVS 388
Cdd:PRK11073 211 SLeLPDNVRLIRdydPSLPELAH-------------DPDQIEQVLLNIVRNalqalgpeggtiTLRTRTAFQLTLHGERY 277
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1452482242 389 EHEAKVFVHDDGIGIDegvlAEWNES---PggKVLPSSYGNGYGLYICQEIMNKQGGsmRIESSEEMGTTIFITFL 461
Cdd:PRK11073 278 RLAARIDIEDNGPGIP----PHLQDTlfyP--MVSGREGGTGLGLSIARNLIDQHSG--KIEFTSWPGHTEFSVYL 345
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
396-458 |
1.48e-04 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 44.13 E-value: 1.48e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1452482242 396 VHDDGIGIDEGVLAEWNE---SPGGKvlpssyGNGYGLYICQEIMNKQGGSMRIESSEEMGTTIFI 458
Cdd:PRK11086 472 VSDDGPGIAPDEIDAIFDkgySTKGS------NRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFV 531
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
363-461 |
3.17e-04 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 43.12 E-value: 3.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 363 QIFLNVLDNTIKYSDATQIRMNVIVSEHEAKVFVHDDGIGIDEGvlaewnespggkvlpSSYGNGYGLYICQEIMNKQGG 442
Cdd:PRK10600 472 QIAREALSNALKHAQASEVVVTVAQNQNQVKLSVQDNGCGVPEN---------------AERSNHYGLIIMRDRAQSLRG 536
|
90
....*....|....*....
gi 1452482242 443 SMRIESSEEMGTTIFITFL 461
Cdd:PRK10600 537 DCRVRRRESGGTEVVVTFI 555
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
366-463 |
5.18e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 39.33 E-value: 5.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 366 LNVL-DNTIKYS-----DATQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAEWnespGGKVLPSSYGNGYGLYICQEIMNK 439
Cdd:cd16957 6 LQVLvENAIRHAfpkrkENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLL----GKTTVTSEKGTGTALENLNRRLIG 81
|
90 100
....*....|....*....|....*..
gi 1452482242 440 ---QGGSMRIESSEEMGTTifITFLLP 463
Cdd:cd16957 82 lfgSEACLHIESEVHGGTE--VWFVIP 106
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
255-460 |
6.95e-04 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 41.97 E-value: 6.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 255 ITHELKTPLTAIIGYVDLI------PKLKAkEDVQESLRYVAVESERLLSLVEELL---KSSKYGTSTFEVSPTVVDIKE 325
Cdd:PRK13557 170 IAHDFNNLLQVMSGYLDVIqaalshPDADR-GRMARSVENIRAAAERAATLTQQLLafaRKQRLEGRVLNLNGLVSGMGE 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 326 LAE----EAVSIV---KPRLQ-------QFEIEVINeltdvhvladfdktkqIFLNVLDNTIKYSDATQIRMNVIVSEHE 391
Cdd:PRK13557 249 LAErtlgDAVTIEtdlAPDLWncridptQAEVALLN----------------VLINARDAMPEGGRVTIRTRNVEIEDED 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 392 AKVF------------VHDDGIGIDEGVLAEWNE-----SPGGKvlpssyGNGYGLYICQEIMNKQGGSMRIESSEEMGT 454
Cdd:PRK13557 313 LAMYhglppgryvsiaVTDTGSGMPPEILARVMDpffttKEEGK------GTGLGLSMVYGFAKQSGGAVRIYSEVGEGT 386
|
....*.
gi 1452482242 455 TIFITF 460
Cdd:PRK13557 387 TVRLYF 392
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
371-462 |
1.42e-03 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 38.74 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 371 NTIKYSDA----TQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAE-WNESPGGkvlpssygnGYGLYICQEIMNkqggSMR 445
Cdd:COG2172 45 NAVRHAYGgdpdGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDpYSTLAEG---------GRGLFLIRRLMD----EVE 111
|
90
....*....|....*..
gi 1452482242 446 IESSEEmGTTIFITFLL 462
Cdd:COG2172 112 YESDPG-GTTVRLVKRL 127
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-464 |
1.76e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 37.69 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 367 NVLDNTIKYSDaTQIRMNVIVSEHEAKVFVHDDGIGIDEGVL------------AEWNESPggkvlpssyGNGYGLYICQ 434
Cdd:cd16949 7 NVLRNALRYSP-SKILLDISQDGDQWTITITDDGPGVPEDQLeqiflpfyrvdsARDRESG---------GTGLGLAIAE 76
|
90 100 110
....*....|....*....|....*....|
gi 1452482242 435 EIMNKQGGSMRIESSEEMGttIFITFLLPK 464
Cdd:cd16949 77 RAIEQHGGKIKASNRKPGG--LRVRIWLPA 104
|
|
| PRK09966 |
PRK09966 |
diguanylate cyclase DgcN; |
127-235 |
2.42e-03 |
|
diguanylate cyclase DgcN;
Pssm-ID: 182171 [Multi-domain] Cd Length: 407 Bit Score: 39.99 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 127 PAPIllfSSPVYYGNDVIGSVRfineLTGEKEVLTNVGWTFL--MTSLCLVAAGIffAIRLARSLHKP-IDQLRQMAQRL 203
Cdd:PRK09966 125 PAPI---IQPIRHNGETIGEVR----LTARDSSISHFIWFSLavLTGCILLASGI--AITLTRHLHNGlVEALKNITDVV 195
|
90 100 110
....*....|....*....|....*....|....*.
gi 1452482242 204 ----ANGDYKSKIELNEYVEIAQLSASFNAMADGIE 235
Cdd:PRK09966 196 hdvrSNRNFSRRVSEERIAEFHRFALDFNSLLDEME 231
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-460 |
4.24e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 37.06 E-value: 4.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 357 DFDKTKQIFLNVLDNTIKYS-DATQIRMNVIVSEHEAKVFVHDDGIGIDEGVLAEWNES-PGGKVLPSSYGN-GYGLYIC 433
Cdd:cd16975 1 DTLLLSRALINIISNACQYApEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELfYRDDTSRRSGGHyGMGLYIA 80
|
90 100
....*....|....*....|....*..
gi 1452482242 434 QEIMNKQGGSMRIESSEEMGTTIFITF 460
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
297-460 |
6.66e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 38.73 E-value: 6.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 297 LSLVEELLksskYGTSTFEVsptvVDIKELAEEAVSIVKPRLQQFEIEVINELTDVHVLADfdktkQ-----IFLN-VLD 370
Cdd:COG3920 343 LALVHELL----YQSEDWEG----VDLRDYLRELLEPLRDSYGGRGIRIELDGPDVELPAD-----AavplgLILNeLVT 409
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 371 NTIKY----SDATQIRMNVIVSEHEAKVFVHDDGIGIDEGVlaewnESPGGKvlpssygnGYGLYICQEIMNKQGGSMRI 446
Cdd:COG3920 410 NALKHaflsGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDV-----DPPARK--------GLGLRLIRALVRQLGGTLEL 476
|
170
....*....|....
gi 1452482242 447 ESSEemGTTIFITF 460
Cdd:COG3920 477 DRPE--GTRVRITF 488
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-459 |
8.32e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 36.11 E-value: 8.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1452482242 367 NVLDNTIKYSDATQI---RMNVIVSEH--EAKVFVHDDGIGIDEGVLAE-----WNESPGGkvlpssyGNGYGLYICQEI 436
Cdd:cd16915 7 NLIDNALDALAATGApnkQVEVFLRDEgdDLVIEVRDTGPGIAPELRDKvfergVSTKGQG-------ERGIGLALVRQS 79
|
90 100
....*....|....*....|...
gi 1452482242 437 MNKQGGSMRIESSEEMGTTIFIT 459
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFSIR 102
|
|
| |
