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Conserved domains on  [gi|1468255912|ref|WP_117224684|]
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DNA topoisomerase IV subunit A [Staphylococcus aureus]

Protein Classification

DNA gyrase/topoisomerase IV subunit A( domain architecture ID 11415135)

DNA gyrase/topoisomerase IV subunit A is part of a type II topoisomerase that relaxes supercoiled DNA, as well as break and join 2 DNA strands simultaneously in an ATP-dependent manner

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-797 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


:

Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 1087.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   1 MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDS 80
Cdd:COG0188     6 PAERIIPVNLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  81 SVYEAMVRLSQDWKLRHVLIEMYGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRF 160
Cdd:COG0188    86 AVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARF 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 161 PNLLVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVR 240
Cdd:COG0188   166 PNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVR 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 241 SKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYLYKNS 320
Cdd:COG0188   246 AKAEIEELKRGREQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHT 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 321 DLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKR 400
Cdd:COG0188   326 QLQTSFGINMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGLLIALDNIDEVIAIIRASKDPD 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 401 DAKENLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERL 480
Cdd:COG0188   406 EAKEALMERFGLSEIQAEAILDMRLRRLTGLEREKIEDEYAELLKEIAELEDILASEERLLKIIKEELLEIKKKYGDERR 485
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 481 SLieAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNAS-----GVEDIGLKDGDSLLKHQEVNTQDTVLVFTNK 555
Cdd:COG0188   486 TE--IEEAEGEIDIEDLIPDEDVVVTLSHKGYIKRTPLDTYRAQrrggkGVSGMGTKEEDFVEHLFVASTHDTLLFFTNK 563
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 556 GRYLFIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFNTDAFYVFATQNGMIKKSTVPLFKTTRfNKPLIATK 635
Cdd:COG0188   564 GRVYRLKVYELPEGSRTAKGKPIVNLLPLEPGEKITAVLPVKEFDEDKYLLFATKKGTVKKTPLSDFSNIR-KNGIIAIN 642
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 636 VKENDDLISVMRFEKDQLITVITNKGMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKR 715
Cdd:COG0188   643 LKEGDELVGVALTDGDDDVLLATSNGKAIRFPESDVRPMGRTARGVRGIRLKEGDEVVGMAVVDEEDDLLTVTENGYGKR 722
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 716 ISFKILQVAKRAQRGITLLKELKKNPHrIVAAHVVTgEHSQYTLYSKSNEEHGL-INDIHKSEQYTNGSFIVDTDDFGEV 794
Cdd:COG0188   723 TPLSEYRLQGRGGKGVITIKLTEKNGK-LVGALVVN-DDDELMLITSSGQLIRTpVSDIRVTGRNTQGVRLIRLDEGDKV 800

                  ...
gi 1468255912 795 IDM 797
Cdd:COG0188   801 VSV 803
 
Name Accession Description Interval E-value
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-797 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 1087.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   1 MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDS 80
Cdd:COG0188     6 PAERIIPVNLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  81 SVYEAMVRLSQDWKLRHVLIEMYGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRF 160
Cdd:COG0188    86 AVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARF 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 161 PNLLVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVR 240
Cdd:COG0188   166 PNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVR 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 241 SKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYLYKNS 320
Cdd:COG0188   246 AKAEIEELKRGREQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHT 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 321 DLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKR 400
Cdd:COG0188   326 QLQTSFGINMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGLLIALDNIDEVIAIIRASKDPD 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 401 DAKENLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERL 480
Cdd:COG0188   406 EAKEALMERFGLSEIQAEAILDMRLRRLTGLEREKIEDEYAELLKEIAELEDILASEERLLKIIKEELLEIKKKYGDERR 485
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 481 SLieAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNAS-----GVEDIGLKDGDSLLKHQEVNTQDTVLVFTNK 555
Cdd:COG0188   486 TE--IEEAEGEIDIEDLIPDEDVVVTLSHKGYIKRTPLDTYRAQrrggkGVSGMGTKEEDFVEHLFVASTHDTLLFFTNK 563
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 556 GRYLFIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFNTDAFYVFATQNGMIKKSTVPLFKTTRfNKPLIATK 635
Cdd:COG0188   564 GRVYRLKVYELPEGSRTAKGKPIVNLLPLEPGEKITAVLPVKEFDEDKYLLFATKKGTVKKTPLSDFSNIR-KNGIIAIN 642
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 636 VKENDDLISVMRFEKDQLITVITNKGMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKR 715
Cdd:COG0188   643 LKEGDELVGVALTDGDDDVLLATSNGKAIRFPESDVRPMGRTARGVRGIRLKEGDEVVGMAVVDEEDDLLTVTENGYGKR 722
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 716 ISFKILQVAKRAQRGITLLKELKKNPHrIVAAHVVTgEHSQYTLYSKSNEEHGL-INDIHKSEQYTNGSFIVDTDDFGEV 794
Cdd:COG0188   723 TPLSEYRLQGRGGKGVITIKLTEKNGK-LVGALVVN-DDDELMLITSSGQLIRTpVSDIRVTGRNTQGVRLIRLDEGDKV 800

                  ...
gi 1468255912 795 IDM 797
Cdd:COG0188   801 VSV 803
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-743 0e+00

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 1020.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   1 MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDS 80
Cdd:PRK05561    6 MLEGIEDLPLEEFLEERYLRYAMYVIMDRALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYHPHGDS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  81 SVYEAMVRLSQDWKLRHVLIEMYGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRF 160
Cdd:PRK05561   86 SIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLPARF 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 161 PNLLVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTG-GIIQGIDGIKKAYESGKGRIIV 239
Cdd:PRK05561  166 PNLLLNGATGIAVGMATDIPPHNLREVIDAAIHLIDNPDATLEELMEFVPGPDFPTGgEIITGRDGIRKAYETGRGSIRV 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 240 RSKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTG-LRIAIELKKD-VNSESIKNYLY 317
Cdd:PRK05561  246 RARWEIEDLAGGRWQIVITELPYQVSKAKLIEQIAELMNAKKLPGIADVRDESDRENpVRIVIEPKSNrVDPEALMNHLF 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 318 KNSDLQISYNFNMVAIS-DGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSS 396
Cdd:PRK05561  326 ATTDLESSYRVNMNAIGlDGRPRVKGLKEILSEWLDHRREVVTRRSQFRLDKVEKRLHILEGLLIAFLNIDEVIRIIRES 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 397 KnkrDAKENLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFK 476
Cdd:PRK05561  406 D---EPKANLMARFDLSEIQAEAILELRLRRLAKLEEIEIRKEQDELRKEIAELEAILASERKLRKLIKKELKADAKKFG 482
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 477 SERLSLIEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGvedIGLKDGDSLLKHQEVNTQDTVLVFTNKG 556
Cdd:PRK05561  483 DPRRTPIEEAEEAIAIDEEALIPDEPVTVVLSKKGWVRRAKGHSIDASG---LSFKEGDSLLFAFEARTTDKLLLFTSTG 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 557 RYLFIPVHKLADIRwKElGQHVSQIVPIEEDEVVINVFnekDFNTDAFYVFATQNGMIKKSTV-PLFKTTRFNKPLIAtk 635
Cdd:PRK05561  560 RVYSLPVHELPSAR-GD-GEPLTGLVDLAPGEEIVHVL---AFDPDQKLLLASSAGYGFVVTLeDLVARTRAGKAVIN-- 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 636 VKENDDLISVMRFEKDQLITVITNKGMSLTYNTSELSDTGlRAAGVKSINLKA-EDFVVMTEGVSENDTILMATQRGSLK 714
Cdd:PRK05561  633 LKDGDEVLPPVPVEDDDHLAAITSNGRLLVFPLSELPELG-KGKGVKLINLPKdDDGLVDLRVLNPEDGLVLLTAGKRKL 711
                         730       740       750
                  ....*....|....*....|....*....|.
gi 1468255912 715 RISFKILQ--VAKRAQRGITLLKELKKNPHR 743
Cdd:PRK05561  712 KLKPSELEkyRGKRARRGRLLPRGLKRVPRF 742
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
5-742 0e+00

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 911.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   5 IQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDSSVYE 84
Cdd:TIGR01061   1 IFNKPLEEVFGESFGKYAKYIIQDRALPDIRDGLKPVQRRILYAMFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  85 AMVRLSQDWKLRHVLIEMYGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLL 164
Cdd:TIGR01061  81 AMVRMSQDWKNNWTLVEMHGNNGSIDGDNAAAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 165 VNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVRSKVE 244
Cdd:TIGR01061 161 INGATGIAAGYATNIPPHNLNEVIDALIYRIDHPNCSVDKLMEIVKGPDFPTGGIIQGEDGISKAYETGKGKFIIRAKIE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 245 EETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYLYKNSDLQI 324
Cdd:TIGR01061 241 IEVNKNGLNQIVITEIPYETNKANIVKKIEEIIFDNKVAGIEEVRDESDRNGIRIIIELKKDANAEKILNFLFKHTDLQI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 325 SYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKRDAKE 404
Cdd:TIGR01061 321 NYNFNMVAIANRTPIQVGLLSYLDAYIKHCHEVIINRSKYELEKASKRLEIVEGLIKAISIIDEIIKLIRSSEDKSDAKE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 405 NLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERLSLIE 484
Cdd:TIGR01061 401 NLIDNFKFTENQAEAIVSLRLYRLTNTDIFELKEEQNELEKKIISLEQIIASEKARNKLLKKQLEEYKKQFAQQRRSQIE 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 485 AEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGVEDIGLKDGDSLLKHQEVNTQDTVLVFTNKGRYLFIPVH 564
Cdd:TIGR01061 481 DFINQIKINESELIENEDYYVLITKAGYIKRTSNRSFASSKYTDFGSKDDDILFAQTIANTTDQILIFTSLGNIINIPVH 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 565 KLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFNTDA-FYVFATQNGMIKKSTVPLFKTTRFNKPLIATKVKENDDLI 643
Cdd:TIGR01061 561 KLADIRWKDLGEHLSNKITFDENETIVFVGTMNEFDVDQpILVLASKLGMVKRIELTELNIKRNSKATLCIKLKDKDHLI 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 644 SVMRFEKDQLITVITNKGMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKRISFKILQV 723
Cdd:TIGR01061 641 SAFLQQKDKLICLVSDLGYALVFHTNEIPVVGAKAAGVKGMKLKEDDQVKSGVIFEANESLVLLTQRGSVKRLSISELVV 720
                         730
                  ....*....|....*....
gi 1468255912 724 AKRAQRGITLLkELKKNPH 742
Cdd:TIGR01061 721 TSRAATGKKLL-PLKKKPH 738
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
27-471 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 637.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  27 QERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDSSVYEAMVRLSQDWKLRHVLIEMYGNN 106
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 107 GSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIPPHNLAE 186
Cdd:cd00187    81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 187 VIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVRSKVEEETLRnGRKQLIITEIPYEVNK 266
Cdd:cd00187   161 VIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIEDDE-GRNTIEITELPYQVNK 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 267 SSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYLYKNSDLQISYNFNMVAIS-DGRPKLMGIRQ 345
Cdd:cd00187   240 AKLKEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDpNGRPKKLNLKE 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 346 IIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKnkrDAKENLIEVYE---FTEEQAEAIVM 422
Cdd:cd00187   320 ILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEVINLIRSSD---EAKKALIEELEklgFSEIQADAILD 396
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1468255912 423 LQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEI 471
Cdd:cd00187   397 MRLRRLTKLEREKLLKELKELEAEIEDLEKILASEERPKDLWKEELDEF 445
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
8-461 0e+00

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 584.91  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912    8 LSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDSSVYEAMV 87
Cdd:smart00434   1 IDIEDFINKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   88 RLSQDWKLRHVLIEMYGNNGSI-DNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVN 166
Cdd:smart00434  81 RMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  167 GSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTggiiqgidgikKAYESGKGRIIVRSKVEEE 246
Cdd:smart00434 161 GSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPT-----------GGEIVGPGKYVVRGKIEIE 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  247 TlrngRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDET-DRTGLRIAIELKKDVNSESIKNYLYKNSDLQIS 325
Cdd:smart00434 230 D----DNTIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTT 305
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  326 YNFNMVAISD-GRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAE-KRMHIVEGLIKALSILDKVIELIRSSKNKR-DA 402
Cdd:smart00434 306 FSINMLALFDnGRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHILEGLFIALSIIDEIIVLIRSSKDLAkEA 385
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1468255912  403 KENLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALL 461
Cdd:smart00434 386 KEKLMERFELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILASEEWLN 444
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
29-469 0e+00

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 579.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  29 RALPDVRDGLKPVQRRILYAMYSSgNTHDKNFRKSAKTVGDVIGQYHPHGDSSVYEAMVRLSQDWKLRHVLIEMYGNNGS 108
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 109 -IDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIPPHNLAEV 187
Cdd:pfam00521  80 rIDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 188 IQATLKYIDNPDITVnqLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVRSKVEEETlrngRKQLIITEIPYEVNKS 267
Cdd:pfam00521 160 IDALIALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTS 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 268 SLVKRIDELRADKKVDGIVEVRDETDRtGLRIAIELKKDVNSESIKNYLYKNSDLQISYNFNMVAISDGRPKLMGIRQII 347
Cdd:pfam00521 234 DLIEKIEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEIL 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 348 DSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKRDAKENLIEvyEFTEEQAEAIVMLQLYR 427
Cdd:pfam00521 313 KEFLDHRLEVYERRKEYLLEKLEERLHILEGLLIALNNIDFVIEIIRGSIDRKKAKKNLIE--ELSEIQADYLLDMRLRR 390
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1468255912 428 LTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELN 469
Cdd:pfam00521 391 LTKEEVDKLLEEIDELEKEIAELEKLLASEKKLNDLWIEELD 432
 
Name Accession Description Interval E-value
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-797 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 1087.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   1 MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDS 80
Cdd:COG0188     6 PAERIIPVNLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYHPHGDS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  81 SVYEAMVRLSQDWKLRHVLIEMYGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRF 160
Cdd:COG0188    86 AVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARF 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 161 PNLLVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVR 240
Cdd:COG0188   166 PNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVR 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 241 SKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYLYKNS 320
Cdd:COG0188   246 AKAEIEELKRGREQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHT 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 321 DLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKR 400
Cdd:COG0188   326 QLQTSFGINMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGLLIALDNIDEVIAIIRASKDPD 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 401 DAKENLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERL 480
Cdd:COG0188   406 EAKEALMERFGLSEIQAEAILDMRLRRLTGLEREKIEDEYAELLKEIAELEDILASEERLLKIIKEELLEIKKKYGDERR 485
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 481 SLieAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNAS-----GVEDIGLKDGDSLLKHQEVNTQDTVLVFTNK 555
Cdd:COG0188   486 TE--IEEAEGEIDIEDLIPDEDVVVTLSHKGYIKRTPLDTYRAQrrggkGVSGMGTKEEDFVEHLFVASTHDTLLFFTNK 563
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 556 GRYLFIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFNTDAFYVFATQNGMIKKSTVPLFKTTRfNKPLIATK 635
Cdd:COG0188   564 GRVYRLKVYELPEGSRTAKGKPIVNLLPLEPGEKITAVLPVKEFDEDKYLLFATKKGTVKKTPLSDFSNIR-KNGIIAIN 642
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 636 VKENDDLISVMRFEKDQLITVITNKGMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKR 715
Cdd:COG0188   643 LKEGDELVGVALTDGDDDVLLATSNGKAIRFPESDVRPMGRTARGVRGIRLKEGDEVVGMAVVDEEDDLLTVTENGYGKR 722
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 716 ISFKILQVAKRAQRGITLLKELKKNPHrIVAAHVVTgEHSQYTLYSKSNEEHGL-INDIHKSEQYTNGSFIVDTDDFGEV 794
Cdd:COG0188   723 TPLSEYRLQGRGGKGVITIKLTEKNGK-LVGALVVN-DDDELMLITSSGQLIRTpVSDIRVTGRNTQGVRLIRLDEGDKV 800

                  ...
gi 1468255912 795 IDM 797
Cdd:COG0188   801 VSV 803
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-743 0e+00

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 1020.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   1 MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDS 80
Cdd:PRK05561    6 MLEGIEDLPLEEFLEERYLRYAMYVIMDRALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYHPHGDS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  81 SVYEAMVRLSQDWKLRHVLIEMYGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRF 160
Cdd:PRK05561   86 SIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLPARF 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 161 PNLLVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTG-GIIQGIDGIKKAYESGKGRIIV 239
Cdd:PRK05561  166 PNLLLNGATGIAVGMATDIPPHNLREVIDAAIHLIDNPDATLEELMEFVPGPDFPTGgEIITGRDGIRKAYETGRGSIRV 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 240 RSKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTG-LRIAIELKKD-VNSESIKNYLY 317
Cdd:PRK05561  246 RARWEIEDLAGGRWQIVITELPYQVSKAKLIEQIAELMNAKKLPGIADVRDESDRENpVRIVIEPKSNrVDPEALMNHLF 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 318 KNSDLQISYNFNMVAIS-DGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSS 396
Cdd:PRK05561  326 ATTDLESSYRVNMNAIGlDGRPRVKGLKEILSEWLDHRREVVTRRSQFRLDKVEKRLHILEGLLIAFLNIDEVIRIIRES 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 397 KnkrDAKENLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFK 476
Cdd:PRK05561  406 D---EPKANLMARFDLSEIQAEAILELRLRRLAKLEEIEIRKEQDELRKEIAELEAILASERKLRKLIKKELKADAKKFG 482
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 477 SERLSLIEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGvedIGLKDGDSLLKHQEVNTQDTVLVFTNKG 556
Cdd:PRK05561  483 DPRRTPIEEAEEAIAIDEEALIPDEPVTVVLSKKGWVRRAKGHSIDASG---LSFKEGDSLLFAFEARTTDKLLLFTSTG 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 557 RYLFIPVHKLADIRwKElGQHVSQIVPIEEDEVVINVFnekDFNTDAFYVFATQNGMIKKSTV-PLFKTTRFNKPLIAtk 635
Cdd:PRK05561  560 RVYSLPVHELPSAR-GD-GEPLTGLVDLAPGEEIVHVL---AFDPDQKLLLASSAGYGFVVTLeDLVARTRAGKAVIN-- 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 636 VKENDDLISVMRFEKDQLITVITNKGMSLTYNTSELSDTGlRAAGVKSINLKA-EDFVVMTEGVSENDTILMATQRGSLK 714
Cdd:PRK05561  633 LKDGDEVLPPVPVEDDDHLAAITSNGRLLVFPLSELPELG-KGKGVKLINLPKdDDGLVDLRVLNPEDGLVLLTAGKRKL 711
                         730       740       750
                  ....*....|....*....|....*....|.
gi 1468255912 715 RISFKILQ--VAKRAQRGITLLKELKKNPHR 743
Cdd:PRK05561  712 KLKPSELEkyRGKRARRGRLLPRGLKRVPRF 742
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
5-742 0e+00

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 911.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   5 IQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDSSVYE 84
Cdd:TIGR01061   1 IFNKPLEEVFGESFGKYAKYIIQDRALPDIRDGLKPVQRRILYAMFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  85 AMVRLSQDWKLRHVLIEMYGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLL 164
Cdd:TIGR01061  81 AMVRMSQDWKNNWTLVEMHGNNGSIDGDNAAAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 165 VNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVRSKVE 244
Cdd:TIGR01061 161 INGATGIAAGYATNIPPHNLNEVIDALIYRIDHPNCSVDKLMEIVKGPDFPTGGIIQGEDGISKAYETGKGKFIIRAKIE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 245 EETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYLYKNSDLQI 324
Cdd:TIGR01061 241 IEVNKNGLNQIVITEIPYETNKANIVKKIEEIIFDNKVAGIEEVRDESDRNGIRIIIELKKDANAEKILNFLFKHTDLQI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 325 SYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKRDAKE 404
Cdd:TIGR01061 321 NYNFNMVAIANRTPIQVGLLSYLDAYIKHCHEVIINRSKYELEKASKRLEIVEGLIKAISIIDEIIKLIRSSEDKSDAKE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 405 NLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERLSLIE 484
Cdd:TIGR01061 401 NLIDNFKFTENQAEAIVSLRLYRLTNTDIFELKEEQNELEKKIISLEQIIASEKARNKLLKKQLEEYKKQFAQQRRSQIE 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 485 AEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGVEDIGLKDGDSLLKHQEVNTQDTVLVFTNKGRYLFIPVH 564
Cdd:TIGR01061 481 DFINQIKINESELIENEDYYVLITKAGYIKRTSNRSFASSKYTDFGSKDDDILFAQTIANTTDQILIFTSLGNIINIPVH 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 565 KLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFNTDA-FYVFATQNGMIKKSTVPLFKTTRFNKPLIATKVKENDDLI 643
Cdd:TIGR01061 561 KLADIRWKDLGEHLSNKITFDENETIVFVGTMNEFDVDQpILVLASKLGMVKRIELTELNIKRNSKATLCIKLKDKDHLI 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 644 SVMRFEKDQLITVITNKGMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKRISFKILQV 723
Cdd:TIGR01061 641 SAFLQQKDKLICLVSDLGYALVFHTNEIPVVGAKAAGVKGMKLKEDDQVKSGVIFEANESLVLLTQRGSVKRLSISELVV 720
                         730
                  ....*....|....*....
gi 1468255912 724 AKRAQRGITLLkELKKNPH 742
Cdd:TIGR01061 721 TSRAATGKKLL-PLKKKPH 738
PRK05560 PRK05560
DNA gyrase subunit A; Validated
1-754 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 868.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   1 MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDS 80
Cdd:PRK05560    1 EGDRIIPVNIEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  81 SVYEAMVRLSQDWKLRHVLIEMYGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRF 160
Cdd:PRK05560   81 AVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 161 PNLLVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVR 240
Cdd:PRK05560  161 PNLLVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 241 SKVEEETLrNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYLYKNS 320
Cdd:PRK05560  241 AKAEIEEI-KGREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHT 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 321 DLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKR 400
Cdd:PRK05560  320 QLQTSFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGLLIALDNIDEVIALIRASPTPA 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 401 DAKENLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERL 480
Cdd:PRK05560  400 EAKEGLMERFGLSEIQAQAILDMRLQRLTGLERDKIEDEYKELLALIADLKDILASPERLLEIIKEELLEIKEKFGDPRR 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 481 SliEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNAS-----GVEDIGLKDGDSlLKHQEV-NTQDTVLVFTN 554
Cdd:PRK05560  480 T--EIIEGEGDIDDEDLIPEEDVVVTLTHGGYIKRTPLDEYRAQrrggkGVSGAKTKEDDF-VEHLFVaSTHDTLLFFTN 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 555 KGRYLFIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFNTDAFYVFATQNGMIKKSTVPLFKTTRFNKpLIAT 634
Cdd:PRK05560  557 RGRVYRLKVYEIPEASRTARGRPIVNLLPLEPGEKITAILPVREFDDDKYLFFATKNGTVKKTSLSEFSNIRSNG-IIAI 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 635 KVKENDDLISVMRFEKDQLITVITNKGMSLTYNTSELSDTGLRAAGVKSINLKAEDFVV-MTEGVSENDTILMATQRGSL 713
Cdd:PRK05560  636 NLDEGDELIGVRLTDGDDDILLATKNGKAIRFPESDVRPMGRTARGVRGIKLREGDEVVsMDVVREDSQEILTVTENGYG 715
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|.
gi 1468255912 714 KRISFKILQVAKRAQRGITLLKELKKNpHRIVAAHVVTGEH 754
Cdd:PRK05560  716 KRTPVSEYRLQGRGGKGVITIKITEKN-GKLVGALPVDDDD 755
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
5-790 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 804.61  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   5 IQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDSSVYE 84
Cdd:TIGR01063   1 IVPVNIEEEMKRSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  85 AMVRLSQDWKLRHVLIEMYGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLL 164
Cdd:TIGR01063  81 TLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 165 VNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVRSKVE 244
Cdd:TIGR01063 161 VNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 245 EETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYLYKNSDLQI 324
Cdd:TIGR01063 241 IEEDSKGREAIIVTEIPYQVNKARLIEKIAELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQV 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 325 SYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKRDAKE 404
Cdd:TIGR01063 321 SFGINMLALVKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGLLIALDNIDEVIALIRASQNTEEAKT 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 405 NLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERLSlIE 484
Cdd:TIGR01063 401 RLVERFSLSEIQAQAILDMRLQRLTGLEREKLQEEYKELLELIADLEDILASEERVLEIIREELEEIKEQFGDPRRT-EI 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 485 AEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNAS-----GVEDIGLKDGDSLLKHQEVNTQDTVLVFTNKGRYL 559
Cdd:TIGR01063 480 VYDESEDIDIEDLIARENVVVTLSHNGYVKRVPVSAYRLQkrggkGVSGADMKDDDFIEQLLVASTHDYLLFFTNRGKVY 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 560 FIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFNTDAFYVFATQNGMIKKSTVPLFKTTRfNKPLIATKVKEN 639
Cdd:TIGR01063 560 WLKVYQIPEASRTAKGKPIVNLLPLQPDERITAILSVKEFDDGLYLFFATKNGVVKKTSLTEFSNIR-SNGIIAIKLDDG 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 640 DDLISVMRFEKDQLITVITNKGMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKRISFK 719
Cdd:TIGR01063 639 DELISVRLTSGEDEVMLGSKNGKAVRFPEEDVRPMGRAARGVRGIKLKNEDFVVSLLVVSEESYLLIVTENGYGKRTSIE 718
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1468255912 720 ILQVAKRAQRGITLLKELKKNpHRIVAAHVVTGEHSQYTLYSKSNEEHGLINDIHKSEQYTNGSFIVDTDD 790
Cdd:TIGR01063 719 EYRETSRGGKGVKSIKITDRN-GQVVGAIAVDDDDELMLITSAGKLIRTSVQDVSEQGRNTQGVRLIRLDE 788
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
2-702 0e+00

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 707.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   2 SEIIQdLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDSS 81
Cdd:PRK13979   11 NNIIK-IPLEEAMPENYLPYAVEVAKDRALPDVRDGLKPVHRRILYGAYMLKAFPDKPYYKSARIVGDILGKYHPHGDSS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  82 VYEAMVRLSQDWKLRHVLIEMYGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFP 161
Cdd:PRK13979   90 VYDAMVILAQDFTTRMPLIDGHGNWGSIDGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVDNYSDSEKEPEVLPARYP 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 162 NLLVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVRS 241
Cdd:PRK13979  170 NLLVNGAFGIAVGLATNIPPHNLKEVIDGTLAYIDNNEITTKELMNYIKGPDLPTGGILIGKKSLLSAYETGEGKVTLRA 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 242 KVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKK----VDGIVEVRDETDRTGLRIAIELKKDVN---SESIKN 314
Cdd:PRK13979  250 KTKIEKLENGRLGIVITEFPYRRNKAKLLQTISEMTADKKhskaLENISDIRDESDRNGIRAVIEFKKSADedvAEKVLK 329
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 315 YLYKNSDLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIR 394
Cdd:PRK13979  330 YLYKKTDLQCNISFNMVALADGKPETMGLKTMLKHYVEHQKEVVTRRTKKELEIAEKRFHIVEGFIKAIGIMDEIIKTIR 409
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 395 SSKNKRDAKENLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKK 474
Cdd:PRK13979  410 SSKSKKDASENLIEKFGFTDEQAEAILELMLYRLTGLEIVAFEKEYKELEKLIKKLTKILSSEKELLKVIKKELKEVKEK 489
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 475 FKSERLSLIEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASG--VEDIGLKDGDSLLKHQEVNTQDTVLVF 552
Cdd:PRK13979  490 YGDERRTSIIEDDEKAKIDVEELIVVEDVVITLSNEGFIKRIPLKSYNRSNsnVEDIEYREGDFNKFLIQSNTKDTLLIF 569
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 553 TNKGRYLFIPVHKLADIRWKELGQHVSQIVP-IE-EDEVVINVFNEKDFNTDAFYVFATQNGMIKKSTVPLFKTTrFNKp 630
Cdd:PRK13979  570 TDKGNMYQIKGINIPEFKWKEKGERLDEIIKgIDlESEKIIEAYSIEDFTPQKDFIFITDSGGIKKTSLDKFVTN-YTK- 647
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1468255912 631 LIATKVKENDDLISVM---RFEKDQLITVITNKGMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSEND 702
Cdd:PRK13979  648 LMALKLKKGEKLIKVKlvdRTREEKFIKIKTKKGLSFTVEEPELEPVDRNIIGYQLFDLLPNDSIKKVDFCDNYE 722
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
27-471 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 637.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  27 QERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDSSVYEAMVRLSQDWKLRHVLIEMYGNN 106
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 107 GSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIPPHNLAE 186
Cdd:cd00187    81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 187 VIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVRSKVEEETLRnGRKQLIITEIPYEVNK 266
Cdd:cd00187   161 VIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIEDDE-GRNTIEITELPYQVNK 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 267 SSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYLYKNSDLQISYNFNMVAIS-DGRPKLMGIRQ 345
Cdd:cd00187   240 AKLKEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDpNGRPKKLNLKE 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 346 IIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKnkrDAKENLIEVYE---FTEEQAEAIVM 422
Cdd:cd00187   320 ILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEVINLIRSSD---EAKKALIEELEklgFSEIQADAILD 396
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1468255912 423 LQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEI 471
Cdd:cd00187   397 MRLRRLTKLEREKLLKELKELEAEIEDLEKILASEERPKDLWKEELDEF 445
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
8-461 0e+00

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 584.91  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912    8 LSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDSSVYEAMV 87
Cdd:smart00434   1 IDIEDFINKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   88 RLSQDWKLRHVLIEMYGNNGSI-DNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVN 166
Cdd:smart00434  81 RMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  167 GSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTggiiqgidgikKAYESGKGRIIVRSKVEEE 246
Cdd:smart00434 161 GSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPT-----------GGEIVGPGKYVVRGKIEIE 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  247 TlrngRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDET-DRTGLRIAIELKKDVNSESIKNYLYKNSDLQIS 325
Cdd:smart00434 230 D----DNTIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTT 305
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  326 YNFNMVAISD-GRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAE-KRMHIVEGLIKALSILDKVIELIRSSKNKR-DA 402
Cdd:smart00434 306 FSINMLALFDnGRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHILEGLFIALSIIDEIIVLIRSSKDLAkEA 385
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1468255912  403 KENLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALL 461
Cdd:smart00434 386 KEKLMERFELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILASEEWLN 444
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
29-469 0e+00

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 579.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  29 RALPDVRDGLKPVQRRILYAMYSSgNTHDKNFRKSAKTVGDVIGQYHPHGDSSVYEAMVRLSQDWKLRHVLIEMYGNNGS 108
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFEL-LNLDKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 109 -IDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIPPHNLAEV 187
Cdd:pfam00521  80 rIDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 188 IQATLKYIDNPDITVnqLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVRSKVEEETlrngRKQLIITEIPYEVNKS 267
Cdd:pfam00521 160 IDALIALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED----RKTIVITELPYGVWTS 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 268 SLVKRIDELRADKKVDGIVEVRDETDRtGLRIAIELKKDVNSESIKNYLYKNSDLQISYNFNMVAISDGRPKLMGIRQII 347
Cdd:pfam00521 234 DLIEKIEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEIL 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 348 DSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKRDAKENLIEvyEFTEEQAEAIVMLQLYR 427
Cdd:pfam00521 313 KEFLDHRLEVYERRKEYLLEKLEERLHILEGLLIALNNIDFVIEIIRGSIDRKKAKKNLIE--ELSEIQADYLLDMRLRR 390
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 1468255912 428 LTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELN 469
Cdd:pfam00521 391 LTKEEVDKLLEEIDELEKEIAELEKLLASEKKLNDLWIEELD 432
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
5-740 2.02e-152

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 463.23  E-value: 2.02e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   5 IQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDSSVYE 84
Cdd:TIGR01062   1 IENIDLGNFTEEAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  85 AMVRLSQDWKLRHVLIEMYGNNGSIDN-DPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNL 163
Cdd:TIGR01062  81 AMVLMAQPFSYRYPLVDGQGNWGAPDDpKSFAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 164 LVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGI-IQGIDGIKKAYESGKGRIIVRSK 242
Cdd:TIGR01062 161 LLNGTTGIAVGMATDIPPHNLHELADAALYLIDNPKAGLDDILNIVQGPDFPTEAEiIDKAEEIRKIYETGRGSFRMRAR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 243 VEEETLrngrkQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTG-LRIAIELKKD-VNSESIKNYLYKNS 320
Cdd:TIGR01062 241 WKKEDG-----QIVISALPHQISKSKVIEQIAIQMKDKKLPMISDIRDESDHENpIRVVIVPRSNrVDPDIVMEHLFATT 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 321 DLQISYNFNMVAI-SDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRsskNK 399
Cdd:TIGR01062 316 DLEKSYRLNMNMIgLDNVPAVKNLLEILQEWLVFRRNTVIRRLTYRLNKVLQRLHILEGLRIAFLNIDEVIEIIR---EE 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 400 RDAKENLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSER 479
Cdd:TIGR01062 393 DEPKTILMERFKLSAIQAEAILNLRLRHLAKLEEHAIIDEQSELEKERAILEKILKSERELNQLVKKEIQADATKYGLAR 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 480 LSLIEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGvedIGLKDGDSLLKHQEVNTQDTVLVFTNKGRYL 559
Cdd:TIGR01062 473 RSSLEEREEAKQVSEIDMIPKEPVTIILSKMGWVRSAKGHDIDLST---LKYKAGDSEKAIIEGKSNQKVVFIDSTGRSY 549
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 560 FIPVHKLADIRWKelGQHVSQIVPIEEDEVVINVFNEKD-----FNTDAFYVF-ATQNGMIKKstvplfktTRFNKPLIA 633
Cdd:TIGR01062 550 ALDPDNLPSARGQ--GEPLTGKLLLPIGATITNILMYSPnqlllMASDAGYGFlCNFNDLIAR--------NKAGKALIN 619
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 634 tkVKENDDLISVMRFEKD-QLITVITNKGMSLTYNTSELSDTGlRAAGVKSINLKAEDFVVMTEGVSEndtILMATQRGS 712
Cdd:TIGR01062 620 --LPENASVIAPLPVNGDsDMIAAITEAGRMLVFPIDDLPELS-KGKGNKLIRIPSANAKRGEDGLLD---LKIFNKQDG 693
                         730       740       750
                  ....*....|....*....|....*....|....*...
gi 1468255912 713 L------KRISFK--ILQ--VAKRAQRGITLLKELKKN 740
Cdd:TIGR01062 694 LswndgkRKIQLEpeELQkfLGERGRFGTTLPRGLPKN 731
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
10-668 1.66e-66

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 233.06  E-value: 1.66e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  10 LEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYssgNTHDKNFRKSAKTVGDVIgQYHPHGDSSVYEAMVRL 89
Cdd:PRK09631    4 IKTLFKDNFLQYASYVIKDRAIPDVIDGLKPVQRRILHSLF---EMHDGKFHKVANVVGNTM-KYHPHGDASIYEALVNL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  90 SQdwklRHVLIEMYGNNGSI-DNDPPAAMRYTEAKLSLLAEELLrdINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGS 168
Cdd:PRK09631   80 AN----KDLFIDKQGNFGNLfTGDPASAARYIECRLTPLAKEVL--YNKEITEYEPSYDGRNNEPLCLPAKIPVILIQGA 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 169 TGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNqlmkyikgPDFPTGGIIQGidgikKAYESGKGRIIVRSKVEEETl 248
Cdd:PRK09631  154 EGIAVGMATKILPHNFNEILQAVKSELLGESFALY--------PDFPTGGIVDV-----SEYADGNGKVLVRAKIETKD- 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 249 rngRKQLIITEIPYEVNKSSLVKRIDE-LRADK-KVDGIvevrdeTDRTGLRIAIELK--KDVNSESIKNYLYKNSDLQI 324
Cdd:PRK09631  220 ---EKTIVIREIPFGTTTESLIASIEKaARKGKiKISSI------NDYTAENVEIEIKlpRGVYASEVIEALYAYTDCEV 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 325 SYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHivEGLIKALSI---LDKVIELIRSSKNKRD 401
Cdd:PRK09631  291 SISVNLLVIKDRYPVIYTVTDIIKFHAEHLQKVLKMELELERAKLLEKIF--AKTLEQIFIeerIYKRIETISSEEDVIS 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 402 A--------KENLIEvyEFTEEQAEAIVMLQLYRLTNTDIvalEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKK 473
Cdd:PRK09631  369 IvlselkpfKEELSR--DVTEEDIENLLKIPIRRISLFDI---DKNQKEIRILNKELKSVEKNLKSIKGYAINFIDKLLA 443
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 474 KFKSE-----RLSLIeaeieeikidKEVMVpsEEVILSMTRHGYIKRTsirsfnasGVEDIGLKDGDSLLkhqEVNTQDT 548
Cdd:PRK09631  444 KYSKEyprktEISLI----------KSVDV--REIATKNLKVYYDLKT--------GFVGTSVKDGEFIG---NASYYDK 500
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 549 VLVFTNKGRYLFIPVhklADIRWKELGQHVSQIVPIEE-DEVVINV--------------FNEKDFNTDAFYVFATQNgm 613
Cdd:PRK09631  501 ILVIRKDGTYVVKNI---PDKTFIDKKNVYVGVVDINNsKEQVFSIiyrdkkdnfyyvkrFKIDKFILDKVYRFLPEG-- 575
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1468255912 614 ikksTVPLFKTTRFNKPLIATKVKENDDLISVMRFEKDQ-LITVITNKGMSLTYNT 668
Cdd:PRK09631  576 ----TEILFLSTFEDFSLNLQFVPKPRQKDIVKMFRIDDfLVKGRSAIGKRISSRE 627
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
16-473 6.98e-55

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 203.70  E-value: 6.98e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  16 DRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYssgNTHDKNFRKSAKTVGDVIgQYHPHGDSSVYEAMVRLSQdwkl 95
Cdd:PRK12758   29 NWFLDYASYVILERAVPHIEDGLKPVQRRILHSMK---EMDDGRYNKVANVVGHTM-QYHPHGDASIGDALVQLGQ---- 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  96 RHVLIEMYGNNGSI-DNDPPAAMRYTEAKLSLLAEELLrdINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAG 174
Cdd:PRK12758  101 KDLLIDTQGNWGNIlTGDGAAAPRYIEARLSKFALEVV--FNPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAVG 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 175 YATDIPPHNLAEVIQATLKYIDNPDITVnqlmkYikgPDFPTGGIIQGIdgikkAYESGK--GRIIVRSKVEEETlrngR 252
Cdd:PRK12758  179 LSTKILPHNFNELIDASIAYLKGKEFKL-----Y---PDFPTGGIIDVS-----NYNDGErgGRVRVRAKIEKLD----K 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 253 KQLIITEIPYEVNKSSLVKRIdeLRADKKvdGIVEVRDETDRT--GLRIAIELKKDVNSESIKNYLYKNSDLQISYNFNM 330
Cdd:PRK12758  242 KTLVITEIPYGTTTSSLIDSI--LKANDK--GKIKIKKVEDNTaaDVEILVHLAPGVSPDKTIDALYAFTDCEVSISPNA 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 331 VAISDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHiveglikaLSILDKV-IElirssknKRDAKEnlIEV 409
Cdd:PRK12758  318 CVIIDNKPHFLGVSDILRRSTDHTVSLLKQELEIRLSELEEQWH--------FASLEKIfIE-------ERIYKE--IEE 380
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1468255912 410 YEFTEEQAEAI------VMLQLYR-LTNTDIVALegehkeLEALIKQ-LRHILDNHDALLNVIKEELNEIKK 473
Cdd:PRK12758  381 AETWEAVIEAIdkglepFKKQFIReVTEDDIVRL------TEIKIKRiSKFDSDKADELIARLEAEIAEVKH 446
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
5-366 3.05e-43

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 163.91  E-value: 3.05e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   5 IQDLSleDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSsgnTHDKNFRKSAKTVGDVIGqYHPHGDSSVYE 84
Cdd:PRK09630    1 MSDVS--DLFKTHFMHYASYVILERAIPHILDGLKPVQRRLLWTLFR---MDDGKMHKVANIAGRTMA-LHPHGDAPIVE 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  85 AMVRLSQdwklRHVLIEMYGNNGS-IDNDPPAAMRYTEAKLSLLAEELLrdINKETVSFIPNYDDTTLEPMVLPSRFPNL 163
Cdd:PRK09630   75 ALVVLAN----KGYLIDTQGNFGNpLTGDPHAAARYIEARLSPLAKEVL--FNTDLMTFHDSYDGREKEPDILPAKLPLL 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 164 LVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNqlmkyikgPDFPTGGIIQGIDgikkaYESGKGRIIVRSKV 243
Cdd:PRK09630  149 LLHGVDGIAVGMTTKIFPHNFCELLEAQIAILNDQPFTLL--------PDFPSGGTMDASE-----YQDGLGSITLRASI 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 244 EEETlrngRKQLIITEIPYEVNKSSLVKRIDEL--RADKKVDGIVEVrdETDRTglRIAIELKKDVNSESIKNYLYKNSD 321
Cdd:PRK09630  216 DIIN----DKTLLIKEICPSTTTETLIRSIENAakRGIIKIDSIQDF--STDLP--HIEIKLPKGIYAKDLLRPLFTHTE 287
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1468255912 322 LQISYNFNMVAISDGRPKLMGIRQIidsyLNHQIEVVANRTKFEL 366
Cdd:PRK09630  288 CQVILTSRPTAIYQNKPVETSISEI----LRLHTETLQGYLKKEL 328
52 PHA02592
DNA topisomerase II medium subunit; Provisional
9-473 3.84e-42

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 159.45  E-value: 3.84e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   9 SLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDV-IGQYHpHGDSSVYEAMV 87
Cdd:PHA02592    7 SLKSIVNNEALEYAMYTVEERAIPNLIDGLKPVQRFVIHRALEYAKGNKEKFDKVAAIAGGVaDLGYH-HGETSAQDAGA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  88 RLSQDWKLRHVLIEMYGNNGSIDNDPPAAMRYTEAKLSllaeELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNG 167
Cdd:PHA02592   86 LMANTWNNNIPLLDGQGNFGSRLVQKAAAARYIFARVH----DNFRKIYKDEDLAPVHEDPEHIPPAFYLPIIPMVLLNG 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 168 STGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQlmkyIKGPDFptggiiqgidgIKKAYESGKGRIIVRSKVEeet 247
Cdd:PHA02592  162 VSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPK----VQFPEF-----------KGEVVEIEPGSYEIRGTYE--- 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 248 lRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKvdgIVEVRDETDRtGLRIAIELKKDVNSESIKNYLYKNSDLQISYN 327
Cdd:PHA02592  224 -LNGKTKLHITEIPVKYDRETYVAVLDPLEEKGK---IVSYDDCTED-GFRFKVTLKREENEEATHEKIMKDFGLIERVS 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 328 FNMVAIS-DGRPKLM-GIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVegLIKALSIlDKVIELIRSSKNK-RDAKE 404
Cdd:PHA02592  299 QNITVINeNGKLKVYeNAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLA--LAKAEFI-KRVIAGEIVLQGKtRSELT 375
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1468255912 405 NLIEVYEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEaliKQLRHILDNHDalLNVIKEELNEIKK 473
Cdd:PHA02592  376 EELSDNKDFGEYADKLVAMNIYSMTSDEREKLQKEAEELE---KEHEYWKKTTA--KKEYIKDLEELKK 439
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
28-481 4.99e-18

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 89.34  E-value: 4.99e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   28 ERALPDVRDGLKPVQRRILYAMYSsgnthdKNFRKSAKtVGDVIG------QYHpHGDSSVYEAMVRLSQDWklrhV--- 98
Cdd:PTZ00108   679 ERSIPSLVDGLKPGQRKILFACFK------RNLKNEIK-VAQLSGyvsehsAYH-HGEQSLQQTIVGMAQNF----Vgsn 746
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   99 ---LIEMYGNNGS---IDNDPPAAmRYTEAKLSLLAeellRDINKETVSFIPNY---DDTTLEPMVLPSRFPNLLVNGST 169
Cdd:PTZ00108   747 ninLLYPCGQFGSrlqGGKDHAAA-RYIFTKLSKIT----RYIFPEEDDPILDYledDGQSVEPFYYVPIIPMVLVNGAE 821
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  170 GISAGYATDIPPHNLAEVIQatlkyidnpditvnQLMKYIKGPDFPTggiiqgidgIKKAYESGKGRIIVRSKVEEETL- 248
Cdd:PTZ00108   822 GIGTGFSTSIPNYNPLDIID--------------NLRRRLNGEEVRP---------LVPWYRGFKGTIERNPKGKFISKg 878
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  249 ---RNGRKQLIITEIP--------------YEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIE--------- 302
Cdd:PTZ00108   879 iyeKVPDGTVEITELPigkwtedykeflesETLKEKDVIVDYRDYSTANTVHFTVKLNDGVLEQWEEEGIEkvfklksti 958
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  303 -------------LKKDVNSESI---------------KNYLYKNSDLQISYNFNMVAIsdgrpklmgIRQIIDSYLnhq 354
Cdd:PTZ00108   959 sttnmvlfdengkIKKYSDALDIlkefylvrldlykkrKEYLLGKLERELARLSNKVRF---------IKHVINGEL--- 1026
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  355 ieVVANRTKFELDNAEKRMHIV--EGLIKALSILDKVIELIRSSKNKRDAKENLIEVYEFTEEqAEAIVMLQLYRLTNTD 432
Cdd:PTZ00108  1027 --VITNAKKKDLVKELKKLGYVrfKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAVS-YDYLLSMPIWSLTKEK 1103
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1468255912  433 IVALEGEHKELEALIKQLRHI------LDNHDALLNVIKEELN-EIKKKFKSERLS 481
Cdd:PTZ00108  1104 VEKLNAELEKKEKELEKLKNTtpkdmwLEDLDKFEEALEEQEEvEEKEIAKEQRLK 1159
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
21-381 4.78e-12

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 69.74  E-value: 4.78e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   21 YSKYIIqERALPDVRDGLKPVQRRILYAMYSsgnthdKNFRKSAKtVGDVIG------QYHpHGDSSVYEAMVRLSQDWk 94
Cdd:PLN03128   666 FSQADL-ARSIPSMVDGLKPSQRKVLFACFK------RNLKSEIK-VAQLSGyvaehsAYH-HGEASLASTIIGMAQDF- 735
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   95 lrhvliemYGNN----------------GSIDNdppAAMRYTEAKLSLLAEELLRDINKETVSFIpNYDDTTLEPMVLPS 158
Cdd:PLN03128   736 --------VGSNninlltpsgqfgtrlqGGKDA---ASARYIFTRLSPITRALFPKDDDVLLNYL-NEDGQSIEPEWYCP 803
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  159 RFPNLLVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITvnQLMKYIKGpdfptggiiqGIDGIKKAYESGKGRII 238
Cdd:PLN03128   804 IIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELE--PMHPWYRG----------FKGTITEVSTSRSGSYT 871
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912  239 VRSKVEeetlRNGRKQLIITEIPYEVNKSSLVKRIDELRA--DKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYL 316
Cdd:PLN03128   872 VTGIIE----QIGDTTIRITELPVRKWTQDYKEFLEALLTgtKKKEPEIKDFKENHTDTTVHFTVTLSEEKMARALAEGL 947
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1468255912  317 YKNSDLQ--ISYNfNMVAIS-DGR-PKLMGIRQIIDSYLNHQIEVVANRT-------KFELDNAEKRMHIVEGLIK 381
Cdd:PLN03128   948 EKKFKLSttISTS-NMHLFDkDGKiKKYDSPEDILEEFFHLRLDLYVKRKevllenlEYELKKLDNKARFILAVVK 1022
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
20-188 1.40e-09

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 61.80  E-value: 1.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   20 RYSKYIIQE----------RALPDVRDGLKPVQRRILYAMYSsgnthdKNFRKSAKtVGDVIG------QYHpHGDSSVY 83
Cdd:PLN03237   679 KYSDFVNKElilfsmadlqRSIPSMVDGLKPGQRKILFCSFK------RNFVKEAK-VAQLSGyvsehsAYH-HGEQSLA 750
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912   84 EAMVRLSQDWKLRHVLIEMYGN-------NGSIDNdppAAMRYTEAKLSLLAEELLRDINKETVSFIpNYDDTTLEPMVL 156
Cdd:PLN03237   751 STIIGMAQDFVGSNNINLLLPNgqfgtrlQGGKDH---ASARYIFTRLSPITRFLFPKDDDILLDYL-NEDGQSIEPTWY 826
                          170       180       190
                   ....*....|....*....|....*....|..
gi 1468255912  157 PSRFPNLLVNGSTGISAGYATDIPPHNLAEVI 188
Cdd:PLN03237   827 MPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIV 858
DNA_gyraseA_C pfam03989
DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the ...
652-693 2.49e-03

DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a beta-propeller structure. This region has been shown to bind DNA non-specifically and may stabilize the DNA-topoisomerase complex.


Pssm-ID: 427633 [Multi-domain]  Cd Length: 48  Bit Score: 36.31  E-value: 2.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1468255912 652 QLITVITNKGMSLTYNTSELSDTGLRAAGVKSINLKAEDFVV 693
Cdd:pfam03989   1 DELLLITSKGYVKRTPLSEIREQGRGAKGVKGINLKEGDKVV 42
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
351-476 2.67e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 41.36  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 351 LNHQI-EVVANRTKFELDNAEKRMHIVEGLIKAL-SILDKVIelirssKNKRDAKENLIEVYEFTEEQAEAIVMLQL--- 425
Cdd:PRK04778  261 LKEQIdENLALLEELDLDEAEEKNEEIQERIDQLyDILEREV------KARKYVEKNSDTLPDFLEHAKEQNKELKEeid 334
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1468255912 426 -----YRLTNTDIVALEGEHKELEALIKQLRHI---LDNHDALLNVIKEELNEIKKKFK 476
Cdd:PRK04778  335 rvkqsYTLNESELESVRQLEKQLESLEKQYDEIterIAEQEIAYSELQEELEEILKQLE 393
DNA_gyraseA_C pfam03989
DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the ...
702-750 8.36e-03

DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a beta-propeller structure. This region has been shown to bind DNA non-specifically and may stabilize the DNA-topoisomerase complex.


Pssm-ID: 427633 [Multi-domain]  Cd Length: 48  Bit Score: 35.16  E-value: 8.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1468255912 702 DTILMATQRGSLKRISFKILQVAKRAQRGITLLKeLKKNpHRIVAAHVV 750
Cdd:pfam03989   1 DELLLITSKGYVKRTPLSEIREQGRGAKGVKGIN-LKEG-DKVVSVLVV 47
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
341-474 9.55e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 39.45  E-value: 9.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255912 341 MGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKAL-SILDKVIElirsskNKRDAKENLIEVYEFTEEQAEA 419
Cdd:pfam06160 233 LNVDKEIQQLEEQLEENLALLENLELDEAEEALEEIEERIDQLyDLLEKEVD------AKKYVEKNLPEIEDYLEHAEEQ 306
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1468255912 420 IVMLQL--------YRLTNTDIVALEGEHKELEALIKQ---LRHILDNHDALLNVIKEELNEIKKK 474
Cdd:pfam06160 307 NKELKEelervqqsYTLNENELERVRGLEKQLEELEKRydeIVERLEEKEVAYSELQEELEEILEQ 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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