|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
6-381 |
8.44e-62 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 203.16 E-value: 8.44e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLI 165
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 166 IVSIIVGFLMMIYLPkdqeiqRGPVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFINPLILSN-GHDMS 244
Cdd:cd17324 161 VLALLAALLLWRLLP------SLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVpGFSSS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 245 FVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMnLILPGSGLLLAGLFIWNIMQWSTNPAVQSGVI 324
Cdd:cd17324 235 AIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLT-LLGPSPLLLLVGLVLWGLGFFAAHSALQTRVL 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1468255991 325 QHVEGDTSQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVAF 381
Cdd:cd17324 314 RLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-344 |
9.56e-43 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 152.82 E-value: 9.56e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLI 165
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 166 IVSIIVGFLMMIYLPKDQEIQRGPVNHETPShenhvtskILRPAEVAKYLIITFLVLIANSVTFVFInPLILSNGHDMS- 244
Cdd:COG2814 172 VLALLALLLLLRLLPESRPAARARLRGSLRE--------LLRRPRLLLLLLLAFLLGFGFFALFTYL-PLYLQEVLGLSa 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 245 -FVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLiLPGSGLLLAGLFIWNIMQWSTNPAVQSGV 323
Cdd:COG2814 243 sAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL-AGSLWLLLLALFLLGFGFGLLFPLLQALV 321
|
330 340
....*....|....*....|..
gi 1468255991 324 IQHV-EGDTSQVMSWNMSSLNA 344
Cdd:COG2814 322 AELApPEARGRASGLYNSAFFL 343
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
4-381 |
9.39e-35 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 132.32 E-value: 9.39e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 4 MRLFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGN 83
Cdd:PRK03545 9 LRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASH 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 84 GIIAVAPNFSILVVGRIISSAAAALIivkvLAITAMLS---APKNRG-KMIGLVYTGFSGANVFGVPIGTVIGDLVGWRY 159
Cdd:PRK03545 89 VLSALAWNFTVLLISRIGIAFAHAIF----WSITASLAirvAPAGKKaQALSLLATGTALAMVLGLPLGRVIGQYLGWRT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 160 TFLFLIIVSIIVGFLMMIYLPKdqeiqrgpvnheTPShENHVTSKIL-----RPAEVAKYLiITFLVLIANSVTFVFINP 234
Cdd:PRK03545 165 TFLAIGGGALITLLLLIKLLPL------------LPS-EHSGSLKSLpllfrRPALVSLYL-LTVVVVTAHFTAYSYIEP 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 235 LILS-NGHDMSFVSLALLVNGIAGVIGTSLGGIFSDKItSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFIWNIMQW 313
Cdd:PRK03545 231 FVQQvAGLSENFATLLLLLFGGAGIIGSVLFSRLGNRH-PSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIM 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1468255991 314 STNPAVQSGVIQHVEGDTSQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVAF 381
Cdd:PRK03545 310 CIGLAMQVKVLKLAPDATDVAMALFSGIFNIGIGAGALLGNQVSLHLGLSSIGYVGAALALAALVWSI 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
9-384 |
1.03e-28 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 115.37 E-value: 1.03e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 9 FILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAV 88
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 89 APNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVS 168
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 169 IIVGFLMMIYLPKdqEIQRGPVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFINPLILSNGH-DMSFVS 247
Cdd:cd17325 161 LLALVLALLLLPE--PRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 248 LALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMnLILPGSGLLLAGLFIWNIMQWSTNPAVQSGVIQHV 327
Cdd:cd17325 239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL-PLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1468255991 328 -EGDTSQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVAFTLK 384
Cdd:cd17325 318 pPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-327 |
1.13e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 111.74 E-value: 1.13e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 9 FILSIFIVGMVEMMVAGIM-NLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIA 87
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 88 VAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIV 167
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 168 SIIVGFLMmiYLPKDQEIQRGPVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFINPLILSNGHDMSFVS 247
Cdd:pfam07690 161 SLLAAVLL--LLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 248 LALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILP--GSGLLLAGLFIWNIMQWSTNPAVQSGVIQ 325
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLtlSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
..
gi 1468255991 326 HV 327
Cdd:pfam07690 319 LA 320
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-384 |
3.61e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 102.26 E-value: 3.61e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLI 165
Cdd:COG2271 92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 166 IVSIIVGFLMMIYLpkdqeiqrgpvnhetpshenhvtskilrpaevakYLIITFLVLIANSVTFVFINPLILSNGHDMSF 245
Cdd:COG2271 172 LPGLLLALLRFWLL----------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 246 VSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVM-MLLMNLILPGSGLLLAGLFIWNIMQWSTNPAVQSGVI 324
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAlALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAA 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1468255991 325 QHVEGD-TSQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVAFTLK 384
Cdd:COG2271 298 ELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
6-307 |
4.72e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 102.27 E-value: 4.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLI 165
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 166 IVSIIVGFLMMIYLPKDQEIQRGPvnhetpshenhVTSKILRPAEVAK-----YLIITFLVLIANSVTFVFINPLILSNG 240
Cdd:COG2223 167 ILLLVVAVLAWLFLRDPPAGAAAA-----------AKASLRDQLEALRdprfwLLSLLYFGTFGSFIGFSSWLPPYLVDQ 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1468255991 241 HDMSFVSLALLVN--GIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFI 307
Cdd:COG2223 236 FGLSAATAGLLAAlfALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLL 304
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
11-330 |
8.24e-24 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 101.48 E-value: 8.24e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 11 LSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAP 90
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 91 NFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSII 170
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 171 VGFLmmiylpkdqeiqrgpvnhetpshenhvtskilrpaeVAKYLIITFLVLIANS--VTFVFINPLILSNGHDMS--FV 246
Cdd:cd17321 163 ALLL------------------------------------ARTFSGAVLAAFLLGAalGGLLFLLPLYLQGVLGYSplQA 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 247 SLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSG--LLLAGLFIWNIMQWSTNPAVQSGVI 324
Cdd:cd17321 207 GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSvwLLLPGLVLLGLGLGLFATPLTNAAL 286
|
....*.
gi 1468255991 325 QHVEGD 330
Cdd:cd17321 287 SSVPKE 292
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
6-383 |
2.73e-23 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 99.96 E-value: 2.73e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLH-VSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNG 84
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 85 IIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLvGWRYTFLfL 164
Cdd:cd17473 81 AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFL-V 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 165 IIVSIIVGFLMMIYLPKDQeiqrgpVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFInPLILSN--GHD 242
Cdd:cd17473 159 YLLALPVLILVLLFLPEPA------RKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQL-PFLLQErgGGS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 243 MSFVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLiLPGSGLLLAGLFIWNIMQWSTNPAVQSG 322
Cdd:cd17473 232 AALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL-ASGLWVVLLGAILAGLGFGLLLPTLNSW 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1468255991 323 VIQHV-EGDTSQVMSWNMSSLN-AGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVAFTL 383
Cdd:cd17473 311 AMSLVpPELRGRAMGIVTSAFFlGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
42-180 |
1.87e-22 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 92.33 E-value: 1.87e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 42 GQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLS 121
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1468255991 122 APKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSIIVGFLMMIYLP 180
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
23-307 |
5.93e-21 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 93.40 E-value: 5.93e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 23 VAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIIS 102
Cdd:COG2807 37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 103 SAAAALIIVkVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSIIVGFLMMIYLpkd 182
Cdd:COG2807 117 GAGIAVGNV-LLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLL--- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 183 qeiqRGPVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFINPLILSNGHDMSFVSLALLVNGIAGVIGTS 262
Cdd:COG2807 193 ----RRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSL 268
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1468255991 263 LGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFI 307
Cdd:COG2807 269 LVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLL 313
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
6-383 |
2.68e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 91.48 E-value: 2.68e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDlVGWRYTFLFLI 165
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 166 IVSIIVGFLMMIYLPKdqeiqrgpvnhetPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFI-------NPLILS 238
Cdd:cd17474 160 ALIPVAFLAILFLLPE-------------PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLyfafltyLPFLLE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 239 NGHDMSFV--SLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFIWNIMQWSTN 316
Cdd:cd17474 227 LLYGISPIiiGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNL 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1468255991 317 PAVQSGVIQHVEGD-TSQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVAFTL 383
Cdd:cd17474 307 PLLTTLVTELAPEEeRGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
9-383 |
3.00e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 88.25 E-value: 3.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 9 FILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAV 88
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 89 APNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGD--LVGWRYTFLFLII 166
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 167 VSIIVGFLMMIYLPKDQEIQRGPVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFINPLILSNGHDM-SF 245
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSvAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 246 VSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFIWNIMQWSTNPAVQSGVIQ 325
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1468255991 326 HVEGDTSQVMswnMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVAFTL 383
Cdd:cd06174 321 LFPPEIRGTA---FGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
6-291 |
8.62e-19 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 87.07 E-value: 8.62e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:PRK10091 5 ILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRIISSAAAALIIvKVLAITAMLSAPKNRG-KMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFL 164
Cdd:PRK10091 85 FTLSSSYLMLAIGRLVSGFPHGAFF-GVGAIVLSKIIKPGKVtAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 165 IIVSIIVGFLMMIYLPKDQEIQRGPVNHETpshenhvtsKILRPAEVAKYLIITFLVLIANSVTFVFINPLILS-NGHDM 243
Cdd:PRK10091 164 AVFNIAVLASIYFWVPDIRDEAKGGLREQF---------HFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFiSGFSE 234
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1468255991 244 SFVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLM 291
Cdd:PRK10091 235 TSMTFIMMLVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLML 282
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
30-308 |
7.41e-18 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 84.16 E-value: 7.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 30 MSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALI 109
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 110 IVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSIIVGFLMMIYLPKDQeiqrgP 189
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETL-----P 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 190 VNHETPSHEN--HVTSKILRPAEVAKYLIITFLVLIAnSVTFVFINPLILSN--GHDMSFVSLALLVNGIAGVIGTSLGG 265
Cdd:cd17320 180 EEKRKPLLSSllRAYKRVLKNRRFLGYALALGLSFAG-LFAYLAAAPFIYIEqlGLSPAQFGLLFALNAIALILGSLLNG 258
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1468255991 266 IFSDKITSKRWLMISVSIFIV---MMLLMNLILPGSGLLLAGLFIW 308
Cdd:cd17320 259 RLVRRFGPRRLLRLGLLLLLAaalVLLLAALLGGLSLWPLVAPLFL 304
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
6-268 |
2.61e-17 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 81.78 E-value: 2.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLI 165
Cdd:COG0477 96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 166 IVSiIVGFLMMIYLPKDQEIQRGPVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFINPLILSNGHDMSF 245
Cdd:COG0477 176 PLG-LLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
250 260
....*....|....*....|...
gi 1468255991 246 VSLALLVNGIAGVIGTSLGGIFS 268
Cdd:COG0477 255 ALLLLAALLLLLLLLLLLALLLA 277
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
21-307 |
5.68e-16 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 78.88 E-value: 5.68e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 21 MMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRI 100
Cdd:cd17371 16 LLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 101 ISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFS-GANVFGVPIGTVIGDL---VGWRYTFLFLIIVSIIVgFLMM 176
Cdd:cd17371 96 LAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvGWLLATLLAALLFPLLppeIAWRVLFLLGALPALLV-LFIR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 177 IYLPKDQEIQRgpVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFIN---PLILSNGHDMSFVSLALLVN 253
Cdd:cd17371 175 RFVKEPPQWQA--ARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITtwlPSYLTGERGLSFEGSAGYLV 252
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1468255991 254 G--IAGVIGTSLGGIFSDKItSKRWLMISVSI--FIVMMLLMNLILPGSGLLLAGLFI 307
Cdd:cd17371 253 VtiLGGFLGYLAGGFLADRI-GRRNNFALFALgsAISILLYFFLPLSPTLILILGFPL 309
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
6-307 |
6.67e-16 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 78.39 E-value: 6.67e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLI 165
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 166 IVSIIVGFLMMIYLPKDQeiqrgpvnhetpshenhvtskilrpaevakyLIITFLVLIANSVTFVFIN-PLILSNGHDMS 244
Cdd:cd17323 161 IISGFCLILIFLFLPIVL-------------------------------LLGLYVGLVYAILYLFLTAfPYVFGEVYGFS 209
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1468255991 245 --FVSLALLVNGIAGVIGTSLGGIFSDKITskRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFI 307
Cdd:cd17323 210 pgEVGLMYLPIGIGALIGSIIGGRLSDYYY--RRLKKKNGGKPEPEARLPPAFIGAFLFPIGLFI 272
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
10-302 |
2.25e-15 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 76.85 E-value: 2.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 10 ILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVA 89
Cdd:cd17503 2 LLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 90 PNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSI 169
Cdd:cd17503 82 PNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 170 IVGFLMMIylpkdqeiqrgpvnhetpshenhVTSKILRPAEVAKYLIITFLVLIANSVTfVFINPLILSNGHDMS-FVS- 247
Cdd:cd17503 162 LALLLAPL-----------------------LDLRLFKDRNFTLGLLLSFLLGLGLFGA-MFLLPLYLQNVLGYSaFESg 217
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1468255991 248 LALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLL 302
Cdd:cd17503 218 LVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWL 272
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
10-384 |
2.55e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 76.48 E-value: 2.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 10 ILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVA 89
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 90 PNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGwrYTFLFLII-VS 168
Cdd:cd17489 82 TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG--FAVLFIVAaVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 169 IIVGFLMMIYLPKDQEIQRGPVNHETPSHENHVTSKILRPAevakylIITFLVLIANSVTFVFINPLILSNGHDMsfVSL 248
Cdd:cd17489 160 ALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPA------LILFLASIAYGAISTFLPLYAAERGISN--AGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 249 ALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMnLILPGSGLLLAGLFIWNIMQWSTNPAVQSGVIQHVE 328
Cdd:cd17489 232 FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLL-SFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVP 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1468255991 329 GDT-SQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVAFTLK 384
Cdd:cd17489 311 PHRrGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
9-307 |
4.88e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 75.69 E-value: 4.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 9 FILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAV 88
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 89 APNFSILVVGRIISSAAAALIIVKVLAITAMLsAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVS 168
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVFPLAFALVREEF-PPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 169 IIVGFLMMIylpkdqeiqrgpvnhetpshenhVTSKILRPAEVAKYLIITFLVLIA-----NSVTFVFINPLILSNGHDM 243
Cdd:cd17504 160 VLLAALVPL-----------------------IDLRLLRRRNVLLANITALLAGFGmfmvfQLLPQLLQLPTPTGFGLGI 216
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1468255991 244 SFVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFI 307
Cdd:cd17504 217 TEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLL 280
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
9-174 |
9.02e-15 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 74.52 E-value: 9.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 9 FILSIFIVGMVEMMVAGIMNLMSQDLHvSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAV 88
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 89 APNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVS 168
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG 159
|
....*.
gi 1468255991 169 IIVGFL 174
Cdd:cd17502 160 GLALAL 165
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
30-307 |
1.04e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 74.53 E-value: 1.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 30 MSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALI 109
Cdd:cd17319 29 IMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 110 IVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSIIVGFLMMIYLPKdqeiqrgp 189
Cdd:cd17319 109 FPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ-------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 190 vnhetpshenhvtskilrpaeVAKYLIITFLVLIANSvTFVFINPLILSNGHDMSFVSLALL--VNGIAGVIGTSLGGIF 267
Cdd:cd17319 181 ---------------------VWGLALGYFGINYALY-GLLTWLPTYLKQARGFSLKQVGLLaaIPFLAGAIGMILGGRL 238
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1468255991 268 SDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFI 307
Cdd:cd17319 239 SDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILL 278
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
5-179 |
2.29e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 73.76 E-value: 2.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 5 RLFTFILSIFIVGMVEMMVAGIMNLMSQDL-HVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGN 83
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 84 GIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLF 163
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
170
....*....|....*.
gi 1468255991 164 LIIVSIIVGFLMMIYL 179
Cdd:cd17325 360 AAALLLLAAVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-308 |
4.74e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 72.96 E-value: 4.74e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 2 SIMRLFTFILSIFIV-GMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFI 80
Cdd:COG0738 5 NYRRALIAIYLLFFLwGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 81 IGNGIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSaPKNRGKMIGLVYTGFSGANVFGVPIGTVI---GDLVGW 157
Cdd:COG0738 85 LGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLillGLSLSW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 158 RYTFLFLIIVSIIVGFLMMIY-LPKDQEiqrgpvNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFInPLI 236
Cdd:COG0738 164 HLPYLILAVLLLLLALLFLRSkLPEIEE------EEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWL-PLY 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1468255991 237 LSNGHDMS--FVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMnLILPGSGLLLAGLFIW 308
Cdd:COG0738 237 LKDVLGLSeaTAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLA-LLAPGPWLALIGLALV 309
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
14-308 |
1.59e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 71.05 E-value: 1.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 14 FIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFS 93
Cdd:cd17478 6 FLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 94 ILVVGRIISSAAAALIIVKVLAITAMLSaPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSIIVGF 173
Cdd:cd17478 86 LLLLLVALAGIGSAAFHPEGARLASQAA-GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 174 LMMIYLPKDQEIQRgpvnHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTfVFINPLILSNGHDMSFVSLALLVN 253
Cdd:cd17478 165 LLLRLRPLKKPEAK----KAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLT-TFLPFYLVQRGYSLVFAGLLLSLF 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1468255991 254 GIAGVIGTSLGGIFSDKITSKRWL---MISVSIFIVMMLLMNLILPGSGLLLAGLFIW 308
Cdd:cd17478 240 LFAGAIGTLIGGPLSDRFGRRRVIiasLLLAAPFLLLFLLTPGIWSYILLVLAGFLLF 297
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
10-380 |
2.45e-13 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 70.67 E-value: 2.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 10 ILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVA 89
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 90 PNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGanvfGVPIGTVIGDLVGWRYTFLFLIIVSI 169
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGL----GFALGPLLLALVGTAGALPFLIAAVL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 170 IVGFLMMIYLpkdqeiqRGPVNHETPSHENHVTSKILRPAEVAkyLIITFLVLIANSVTFVFINPLILSNGHDMSFVSLA 249
Cdd:cd17477 158 LLLALVPLLL-------TRRAAPEIEEAESISLRRLLRIAPLA--LLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 250 LLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFIWNIMQWSTNPAVQSGVIQHVEG 329
Cdd:cd17477 229 LAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPG 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1468255991 330 -DTSQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVA 380
Cdd:cd17477 309 dELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
11-381 |
6.20e-13 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 69.14 E-value: 6.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 11 LSIFIVGMVEMMVAGIMNLMSQDLHVSEAV---VGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIA 87
Cdd:cd17330 3 LVVFLDALGFGIVFPVLPFYVREFNKLGASgyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 88 VAPNFSILVVGRIISSAAAALIIVkVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIV 167
Cdd:cd17330 83 LSRNLWLLFLARFLDGLTGGNVSV-AQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 168 SIIVGFLMMIYLPKdqeiqrgpvnhetpshenhvtskilrpaeVAKYLIITFLVLIANSV-TFVFINPLILSNGHDMSFV 246
Cdd:cd17330 162 ALLNLVLVLFFLPP-----------------------------LRRLLLVYFLIALAFAGlESVFSLFLKDRFGFSPSQI 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 247 SLALLVNGIAGVI-GTSLGGIFSDKITSKRWLMISVSIFIVMMLLMnLILPGSGLLLAGLFIWNIMQWSTNPAVQSGVIQ 325
Cdd:cd17330 213 GLLLALVGIAGILaQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLL-PFASSVPLLVLAAAILAFGTGIVFPALSALLSK 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1468255991 326 HVE-GDTSQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVAF 381
Cdd:cd17330 292 SVPsKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLS 348
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
19-267 |
1.03e-12 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 68.79 E-value: 1.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 19 VEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVG 98
Cdd:PRK10213 35 VEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 99 RIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFlfliIVSIIVGFLMMIY 178
Cdd:PRK10213 115 RACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVF----NAAAVMGVLCIFW 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 179 LPKDQeiqrgPVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFINPLILS-NGHDMSFVSLALLVNGIAG 257
Cdd:PRK10213 191 IIKSL-----PSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNlAGFGVDGLTLVLLSFGIAS 265
|
250
....*....|
gi 1468255991 258 VIGTSLGGIF 267
Cdd:PRK10213 266 FVGTSLSSFI 275
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
3-307 |
1.65e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.07 E-value: 1.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 3 IMRLFTFILSIFIVGMVeMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIG 82
Cdd:cd17355 3 VVLAVTFLILILSWGIR-YYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 83 NGIIAVAPNFSILVV--GRIISSAAAALIIVKVLAITAmLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYT 160
Cdd:cd17355 82 LVLLALATSLWQLYLlwGLLGGGGAGTLAAVAFATVAA-WWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 161 FLFLIIVSIIVGF---LMMIYLPKDqeIQRGPVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFINPLIL 237
Cdd:cd17355 161 LLVLALLALLVLVpvlLLLRRRPAD--LALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLA 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1468255991 238 SNGHDMSFVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIF-IVMMLLMNLILPGSGLLLAGLFI 307
Cdd:cd17355 239 DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRaLGLALLLLLPFPPLALLLFAALF 309
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
42-294 |
4.31e-12 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 66.89 E-value: 4.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 42 GQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALIIVKVLAItAMLS 121
Cdd:cd17388 41 GVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYI-ADVT 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 122 APKNRGKMIGLVYTGFSGANVFGVPIGTVIGDlVGWRYTFLFLIIVSIIVGFLMMIYLPKDQEIQRGPvNHETPSHENHV 201
Cdd:cd17388 120 PPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRR-AFRWRRANPFG 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 202 TSKILRPAEVAKYLIITFLV--LIANSVTFVFINPLILSNGHDMSFVSLALLVNGIA-GVIGTSLGGIFSDKITSKRWLM 278
Cdd:cd17388 198 SLRWLTGFPGLLGLLAVFFLiqLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLhALFQAFVTGPIAKRLGEKRAIL 277
|
250
....*....|....*.
gi 1468255991 279 ISVSIFIVMMLLMNLI 294
Cdd:cd17388 278 LGLAADALGFLLLAFA 293
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
13-275 |
6.57e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 66.49 E-value: 6.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 13 IFIVGMVEMM----VAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAV 88
Cdd:cd17328 4 LFLINLLNYMdrftIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 89 APNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLV-GWRYTFLFLIIV 167
Cdd:cd17328 84 APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 168 SIIVGFLMMIYLPkdqEIQRGPVNhETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFV----------FINPLIL 237
Cdd:cd17328 164 GVLLAILLLLFVR---EPPRGAAE-GGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVtgalafwaptFFLRAFG 239
|
250 260 270
....*....|....*....|....*....|....*....
gi 1468255991 238 SNGHDMSFVSLAL-LVNGIAGVIGTSLGGIFSDKITSKR 275
Cdd:cd17328 240 VGDLSSADVGLIFgAITCIAGVLGVLLGGILADRLRRKT 278
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
8-306 |
1.92e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 65.07 E-value: 1.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 8 TFILSIFIVGM--VEMMVAGIM-NLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNG 84
Cdd:TIGR00895 18 AIILSFLIMLMdgYDLAAMGFAaPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 85 IIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFL 164
Cdd:TIGR00895 98 LCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 165 IIVSIIVGFLMMIYLP--------KDQEIQRGPVNHETPSHENHVTS----------------KILRPAEVAKYLIITFL 220
Cdd:TIGR00895 178 GIAPLLLLLLLMRFLPesidflvsKRPETVRRIVNAIAPQMQAEAQSalpeqkstqgtkrsvfKALFQGKTARITVLLWL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 221 VLIANSVTFVFINP----LILSNGHDMSFVSLALLVNGIAGVIGTSLGGIFSDKITSKR----WLMISVSIFIVMMLLMN 292
Cdd:TIGR00895 258 LYFMLLVGVYFLTNwlpkLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVtallLLLGAVFAVLVGSTLFS 337
|
330
....*....|....
gi 1468255991 293 LILPGSGLLLAGLF 306
Cdd:TIGR00895 338 PTLLLLLGAIAGFF 351
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
21-307 |
5.29e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.77 E-value: 5.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 21 MMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSR-----PVLLWTLLIFIIGNGIIAVAPNFS-- 93
Cdd:COG2211 28 LLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrPWILIGAIPLALSFVLLFTAPDLSpt 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 94 ----ILVVGRIISSAAAALIIVKVLAITAMLSA-PKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLV------GWRYTFL 162
Cdd:COG2211 108 gkliYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTAL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 163 FLIIVSIIVGFLMMIYLPkdqeiqRGPVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFINPLILSN-GH 241
Cdd:COG2211 188 IFAVLGLLAFLLTFFGTK------ERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGL 261
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1468255991 242 DMSFVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFI 307
Cdd:COG2211 262 SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAA 327
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
6-383 |
2.98e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.48 E-value: 2.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAP-----NFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYT 160
Cdd:cd06173 81 LALLAllgslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 161 FLfLIIVSIIVGFLMMIYLPKDQEIQRGPVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFINPLILSNG 240
Cdd:cd06173 161 FA-INALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 241 HDMSFV-SLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLiLPGSGLLLAGLFIWNIMQWSTNPAV 319
Cdd:cd06173 240 GGGAAGyGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL-SPSLWLLLAALFLLGLAGGLFNVPL 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1468255991 320 QSGVIQHVEGDT-SQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVAFTL 383
Cdd:cd06173 319 NTLLQLRVPDELrGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
11-308 |
3.83e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 60.69 E-value: 3.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 11 LSIFIVGMVEMMVAGIMNLMSQ--DLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAV 88
Cdd:cd17316 6 LGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 89 APNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLV----GWRYTFLFL 164
Cdd:cd17316 86 LPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRILFLIG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 165 IIVSIIVGFLMMIylpkdqeiqrgpvnhetpshenhvtskilrpaeVAKYLIITFLVLIANSVTFVFINPLILS-NGHDM 243
Cdd:cd17316 166 ALPALLALLLRRR---------------------------------TLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSP 212
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1468255991 244 SFVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFIW 308
Cdd:cd17316 213 ATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI 277
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
10-307 |
1.40e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 59.16 E-value: 1.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 10 ILSIFIVGMVEMMVAGIMNL-MSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAV 88
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 89 APNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLvGWRYTFLFLIIVS 168
Cdd:cd17329 85 AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 169 IIVGFLMMIYLPKDQEIQRGPVNHETPShenhVTSKILRPAEVAKYLIITFLVLIANSVTFVFINPLILSNGHD-MSFVS 247
Cdd:cd17329 164 LLAALVLLFLLPETRPKRRAAEKTEILR----GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLgESLLG 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 248 LALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFI 307
Cdd:cd17329 240 LLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVL 299
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
4-176 |
1.43e-09 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 59.09 E-value: 1.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 4 MRLFTFILSIFIVGMVEMMvagIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGN 83
Cdd:cd17370 202 FWLYLLAVALFALGNFSFA---FLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAY 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 84 GIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLF 163
Cdd:cd17370 279 LGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
|
170
....*....|...
gi 1468255991 164 LIIVSIIVGFLMM 176
Cdd:cd17370 359 SAVLALIALLLLL 371
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
6-306 |
1.97e-09 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 58.79 E-value: 1.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:PRK12307 20 LFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRIISSAAAALIIVkVLAITAMLSAPKN-RGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFlFL 164
Cdd:PRK12307 100 SGLASGVIMLTLSRFIVGMGMAGEYA-CASTYAVESWPKHlKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAF-FV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 165 IIVSIIVGFLMMIYLPKDQEIQ------RGPVNHETPSHENHVTSKILRPAEVAKYLIItFLVLI----ANSVTFVFINP 234
Cdd:PRK12307 178 GLLPVLLVIYIRARAPESKEWEeaklsgKGKHSQSAWSVFSLSMKGLFNRAQFPLTLCV-FIVLFsifgANWPIFGLLPT 256
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1468255991 235 LILSNGHDMSFVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMIS-VSIFIVMMLLMNLILPGSGLLLAGLF 306
Cdd:PRK12307 257 YLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGlLMSFLFIFPLFRIPQDNYLLLGACLF 329
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
11-382 |
2.13e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 58.82 E-value: 2.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 11 LSIFIVGMVEMMVAGIMNL-MSQDLHVSEAVVGQL----VTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:cd17391 3 LGNFFTGIGFSLIAPFLPLyIEQLGVTSGGLVELWsglaFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRII-------SSAAAALIIVkvlaitamlSAPKNR-GKMIGLVYTGFSGANVFGVPIGTVIGDLVGW 157
Cdd:cd17391 83 MAFVTNVWQLLILRLLqgvfsgyVPNATALIAS---------QTPKEKsGWALGTLSTGVVAGTLIGPLLGGFLADLFGI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 158 RYTFlFLIIVSIIVGFLMMIYLPKDqeiQRGPVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANS----VTFVFIN 233
Cdd:cd17391 154 RNVF-FITGGLLFLAFLLTLFFVKE---DFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQsiepILTLYIR 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 234 PLILSNGHDMSFVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLIlpGSGLLLAGL-FIWNIMQ 312
Cdd:cd17391 230 QLMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFV--QTPWQLGILrFLLGLAT 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1468255991 313 WSTNPAVQSGVIQHV-EGDTSQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVAFT 382
Cdd:cd17391 308 GGLLPAINSLLAKITpKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFI 378
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
7-307 |
4.67e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 57.61 E-value: 4.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 7 FTFILSIFIVGMveMMVAGIMNLMSQDL-HVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:cd17472 1 LSLIFSLRMLGM--FLVLPVLSVYAKSLpGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRIISSAAAalIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLI 165
Cdd:cd17472 79 AAYATSIYGLILGRALQGSGA--ISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 166 IVSIIVGFLMMIYLPKDQEIqrgpvnhetPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVF--INPLILSN-GHD 242
Cdd:cd17472 157 ILSLVSLLILLFFVPDPPKI---------VQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFfyILPLLLTQlGGG 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1468255991 243 MSFVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGS-GLLLAGLFI 307
Cdd:cd17472 228 KGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSlWLLIIGLII 293
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
9-306 |
5.35e-09 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 57.17 E-value: 5.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 9 FILSIFIVGMVEMMVAGIMNL-MSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSR-PVLLWTLLIFIIGNGII 86
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLfLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRkPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 87 AVAPNF-SILVVGRIISSAAAALI--IVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLF 163
Cdd:cd17471 81 AFLRNYwVLLLVGVVLLSLGAAAFpqLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 164 LIIVSIIVGFLMMIYLPKDQEiqrgpvnHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFInPLILSNGHDM 243
Cdd:cd17471 161 AALLYLVVALLVLFLLPSVKP-------PAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAM-PLYVTNELGG 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1468255991 244 SfVSLALLVNGIAGVIG---TSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLF 306
Cdd:cd17471 233 S-ESWVGLLFGLAAALEipiMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLL 297
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
44-178 |
6.39e-09 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 57.64 E-value: 6.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 44 LVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSaP 123
Cdd:cd06179 37 ISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVP-N 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1468255991 124 KNRGKMIGLVYTGFSGANVFGVPIGT--VIGDLVGWRYTFLFLIIVSIIVGFLMMIY 178
Cdd:cd06179 116 KYRGLVQGVVNLVASPGSALGPLIAGalVEANAAGWRWIFYINAIFNALALILLFFF 172
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
22-307 |
1.16e-08 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 56.43 E-value: 1.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 22 MVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNgIIAVAPNFSILVVGRII 101
Cdd:cd17339 17 SVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGI-LLRSLGGIALLFLGTAL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 102 SSAAAALIIVkVLAITAMLSAPKNRGKMIGLvYT---GFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSIIVGFlmmIY 178
Cdd:cd17339 96 AGAGIAVGNV-LLPSLIKRDFPRRVGLMTGL-YTtsmNLGAALASGLSVPLAQALGGGWRGALAIWALPALLALL---IW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 179 LPKDQEIQRGPVNHETPSHENHVTSKilrpaeVAKYLIITF-LVLIANSVTFVFINPLILSNGHDMSFVSLALLVNGIAG 257
Cdd:cd17339 171 LPQLRRRKRAAAAAAPLTKISVWRSP------LAWQVTLFMgLQSLLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVG 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1468255991 258 VIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFI 307
Cdd:cd17339 245 IPASLLVPILATRLKNQRPIVVLLAVLFIIGVLGLLFAPTALALLWAVLL 294
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
6-180 |
4.74e-08 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 54.53 E-value: 4.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:PRK11652 10 LFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLI 165
Cdd:PRK11652 90 ALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLL 169
|
170
....*....|....*
gi 1468255991 166 IVSIIVGFLMMIYLP 180
Cdd:PRK11652 170 LLGAGVTFSMARWMP 184
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
5-177 |
5.07e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.54 E-value: 5.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 5 RLFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNG 84
Cdd:cd06173 210 LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 85 IIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFL 164
Cdd:cd06173 290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLA 369
|
170
....*....|...
gi 1468255991 165 IIVSIIVGFLMMI 177
Cdd:cd06173 370 GALLLLAALLLLL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-184 |
6.31e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.11 E-value: 6.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMN----LMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSR--PVLLWTLLIF 79
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTwlptYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 80 IIGNGIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRY 159
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|....*
gi 1468255991 160 TFLFLIIVSIIVGFLMMIYLPKDQE 184
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
23-291 |
1.41e-07 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 52.95 E-value: 1.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 23 VAGIMNLMSQDLHVSEAVVGqLVTMYALTFAICGPILV-KLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRII 101
Cdd:cd17359 20 INGALPFLQTDFNLTPFLEG-LVVSSALLGAAIGALFAgRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARII 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 102 SSAAAALIIVKVLAITAMLSAPKNRGKMIGL----VYTGFSGANVFGVPIGTVIGDLV----GWRYTFLFLIIVSIIVgF 173
Cdd:cd17359 99 GGLAVGGASALVPMYIAEVAPAEIRGRLVSLnqlmIVFGQLLAYIVNYLIANAGGADWlgaeGWRWMLGLEAIPAILF-L 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 174 LMMIYLPkdqeiqrgpvnhETPshenHVTSKILRPAevakyLIITFLVLIANSvtFVFIN------PLILSN---GHDMS 244
Cdd:cd17359 178 LGMLFIP------------ESP----RWLVSKGKPI-----LIIGIGLAIFQQ--FVGINvifyygPEIFQNagfSENAA 234
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1468255991 245 FvsLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLM 291
Cdd:cd17359 235 L--LQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLLLI 279
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
24-308 |
2.28e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 52.25 E-value: 2.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 24 AGIMNlMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVL-----LWTLLIFIIgngiiAVAPNFSILVVG 98
Cdd:cd17327 27 AAVMG-MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLsvfivLWGLLTLLT-----AAVKNFGGLIAL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 99 RIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVI------GDLVGWRYTFLFLIIVSIIVG 172
Cdd:cd17327 101 RFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVfkilgvGGLAGWRWLFIIEGLITIIIG 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 173 FLMMIYLP-----------KDQEIQRGPVNHETPSHENHVTS-----KILRPAEVAKYLIITFLVLIANSVTFVFINPLI 236
Cdd:cd17327 181 LVIFFWLPdnpskawflteEEKELAVERLRANQTGKGDQKFKwkqikEAFKDPRTWLLFLFFFCSQITNNGISNFLPLIL 260
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1468255991 237 LSNGHDMSFVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIF-IVMMLLMNLILPGSGLLLAGLFIW 308
Cdd:cd17327 261 KSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLaLVGSIILLAAPNPPGAYFAAYILG 333
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-181 |
2.47e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.19 E-value: 2.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 9 FILSIFIVGMVEMMVAGIMNLMSQD-LHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIA 87
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 88 VAP-NFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLII 166
Cdd:COG2223 290 LALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFA 369
|
170
....*....|....*
gi 1468255991 167 VSIIVGFLMMIYLPK 181
Cdd:COG2223 370 VLALVALVLTLLLYR 384
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
11-381 |
3.49e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.55 E-value: 3.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 11 LSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAP 90
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 91 NFSILVVGRIISSAAAALIIVKVLAITAMLSaPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWrYTFLFLIIVSII 170
Cdd:cd17333 83 SIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSLLTSELS-WSWAYLIIGLIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 171 VGFLMMIYLPKDQEIQRGPVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFInPLILSNGHDMSFVSLAL 250
Cdd:cd17333 161 LLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWV-PSYLVEKKHVSDGLAGY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 251 LVNG--IAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMlLMNLILPGSGLLLAGLFIWNIMQWSTNPAVQSGVIQHVE 328
Cdd:cd17333 240 LLSGfwVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGL-LILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1468255991 329 GDTSQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVAF 381
Cdd:cd17333 319 YAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLAL 371
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
20-307 |
9.54e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.28 E-value: 9.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 20 EMMVAG-IMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVG 98
Cdd:cd17365 14 DLAVMGfVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 99 RIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSIIVGFLMMIY 178
Cdd:cd17365 94 RFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGT 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 179 LpkdqeiqrgpvnhetpshenhvtskilrpaevaKYLIITFLVLIANSVTFVFINPLILSNGHDMSFVSLALLVNGIAGV 258
Cdd:cd17365 174 L---------------------------------LLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGV 220
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1468255991 259 IGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFI 307
Cdd:cd17365 221 IGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFL 269
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
5-178 |
1.26e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.92 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 5 RLFTFILSIFIVGMVEMMVAGIMNL-MSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGN 83
Cdd:cd17329 201 AFLLFLLASFLISLIYFQLESTLPVyVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGF 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 84 GIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLF 163
Cdd:cd17329 281 AVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLI 360
|
170
....*....|....*
gi 1468255991 164 LIIVSIIVGFLMMIY 178
Cdd:cd17329 361 LAALGLIAAALLLGL 375
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
8-177 |
2.45e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 49.11 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 8 TFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAIC-GPILVKLTNRFSSRPVLLWTLLIFIIGNGII 86
Cdd:cd17330 179 LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 87 AVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLII 166
Cdd:cd17330 259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAG 338
|
170
....*....|.
gi 1468255991 167 VSIIVGFLMMI 177
Cdd:cd17330 339 LLLIALFLLSL 349
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
64-307 |
4.10e-06 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 48.52 E-value: 4.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 64 NRFSSRPVLLWTLLIFIIGNGIIAVAPNFS--------ILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGkmiglVYT 135
Cdd:cd17368 65 DRIGRKPAMTLTLAIMALGTLLIALAPTYAtigiaaplLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRG-----FYT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 136 GFSGAN-VFGVPIGTVIGDLV------------GWRYTFlFLIIVSIIVGFLMMIYLPKDQEIQRGPvnhetpsHENHVT 202
Cdd:cd17368 140 SWQSASqQVAIVAGALVGYLLsltltaealaewGWRIPF-FIGLLIIPLGLWLRRSLEETEAFLERK-------ARPTRR 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 203 SKILRPAEVAKYLIITFLVLIANSVTFVFINPLILSNGHDMSFVS-----LALLVNGIAGVIGTSLGGIFSDKITSKRWL 277
Cdd:cd17368 212 ELFALLANNRRIILLGMLLVAGSTVTFYFTTVYTPTYAKTVLGLSardsfLVTLLAGVANFIWAPLGGALSDRIGRRPVL 291
|
250 260 270
....*....|....*....|....*....|....*
gi 1468255991 278 MIS-----VSIFIVMMLLMNliLPGSGLLLAGLFI 307
Cdd:cd17368 292 LVItlaalVTLYPVFAWLTA--APSFGRLLLVLLV 324
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
215-381 |
5.80e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.66 E-value: 5.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 215 LIITFLVLIANSVTFVFINPLILSNGHDMSFVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMnLI 294
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC-AL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 295 LPGSGLLLAGLFIWNIMQWSTNPAVQSGVIQHVEGDT-SQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIG 373
Cdd:COG2814 95 APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLA 174
|
....*...
gi 1468255991 374 ALGLIVAF 381
Cdd:COG2814 175 LLALLLLL 182
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
42-148 |
6.69e-06 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 47.65 E-value: 6.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 42 GQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALIIVKVlAITAMLS 121
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLST-AIVADVT 145
|
90 100
....*....|....*....|....*..
gi 1468255991 122 APKNRGKMIGLVYTGFSGANVFGVPIG 148
Cdd:cd17389 146 SPKKRSKGMALIGVAFSLGFIIGPMIG 172
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
14-180 |
1.19e-05 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 47.18 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 14 FIVGMVEMMVAGIMNLMSQDLHVSEA---VVGQLVTMYALtfaiCGPILV-KLTNRFSSRPVLLWTLLIFIIGNGIIAVA 89
Cdd:cd17358 16 IAVGWSSPALPSLMSDNSLSLPLTVAqfsWFGSLLTLGAL----IGALLSgKLADRIGRKRTLLISAIPCILGWLLIAFA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 90 PNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIglvyTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSI 169
Cdd:cd17358 92 KDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALG----SLNQLLVNIGILLGYVLGSFLPWRTLALIGAIPPV 167
|
170
....*....|.
gi 1468255991 170 IVgFLMMIYLP 180
Cdd:cd17358 168 VF-LILLFFIP 177
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
65-310 |
1.49e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 46.75 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 65 RFSSRPVLLWTLLIFIIGNGIIAVAPNFS--------ILVVGRIIS-------SAAAALIIVKvlaitamlSAPKNRgkm 129
Cdd:cd17369 70 RIGRKKTLVLTLLLMGIATFLIGLLPTYAqigilapiLLVLLRLLQglalggeWGGAVLMAVE--------HAPPKR--- 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 130 iglvyTGFSGANVF-GVPIGTVIGDLV----------------GWRYTFLFLIIVsIIVGFLMMIYLpkdqeiqrgpvnH 192
Cdd:cd17369 139 -----RGFYGSFPQlGAPVGLLLATGVflllsallsdeaflswGWRIPFLLSAVL-VAVGLYIRLRL------------E 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 193 ETPSHENHVTSKILRPAEVA-------KYLIITFLVLIANSVTFVFINPLILS-----NGHDMSFVSLALLVNGIAGVIG 260
Cdd:cd17369 201 ETPVFRRAKEAGQVVRAPLVevlrrhwRALLLAIGLRLAENVLFYLFTTFALSyatqtLGVDRSTVLLAVLIASVVAAIT 280
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1468255991 261 TSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSG---LLLAGLFIWNI 310
Cdd:cd17369 281 IPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGStwlIVLAAVVVLGV 333
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
53-176 |
2.26e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 46.11 E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 53 AICGPILV-KLTNRFSSRPVLLWTLLIFIIGNGIIAVAP---NFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGK 128
Cdd:pfam00083 59 CFIGSLFAgKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGA 138
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1468255991 129 MIGLvytgFSGANVFGVPIGTVIG-------DLVGWRYTFLFLIIVSIIVGFLMM 176
Cdd:pfam00083 139 LGSL----YQLAITFGILLAYIFGlglnktsNSDGWRIPLGLQLVPALLLIIGLL 189
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
53-175 |
2.40e-05 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 46.19 E-value: 2.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 53 AICGPILV-KLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIG 131
Cdd:cd17362 52 ALLGSLVAgALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVS 131
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1468255991 132 LVYTGFSGANVFGVPIGTVIGDLV-GWRYTFLFLIIVSIIVGFLM 175
Cdd:cd17362 132 LKELFIVLGILLGYVSGYAFADVVgGWRYMYGLAAPPALLLGIGM 176
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
21-382 |
3.90e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 45.29 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 21 MMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRI 100
Cdd:cd17331 17 WLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 101 ISSAAAALIIVKvlAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSIIVGFLMMIYLP 180
Cdd:cd17331 97 PSVFMHAMQAAQ--MVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 181 KDQEIQRGPVNHETPSHE----NHVTSKILRPAEVAKYLIITFLVLIANSVtFVFINPLIL---------SNGHDMSFVS 247
Cdd:cd17331 175 SNTKSKREKEAKESASPPsvfnLKEILRLLRLPGVAFLLLVKLLSGLPIGM-FQSMFSLVAmdffgltpeENGYLMSYAG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 248 LALLVngIAGVIGTSLGGIFSDKITSKrwlmISVSIFIVMMLLMNLIlPGSGLLLAGLFIWNIMQWSTNPAVQSGVIQHV 327
Cdd:cd17331 254 VLGMV--VQGLLVGPLTKRFGERSLLK----LSVALLAIGYLLLAFV-TTVWQLLVLLLPLVIGGSVLYTVITSLLTKAV 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1468255991 328 -EGDTSQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAIIGALGLIVAFT 382
Cdd:cd17331 327 pPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
15-305 |
4.03e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 45.37 E-value: 4.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 15 IVGMVEMMVA---------GIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:cd06180 1 LAGALALAVAmgigrfaytPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGfSGANVF----GVPIGTVIGDlvGWRYTF 161
Cdd:cd06180 81 MALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAG-VGLGIAlsglLVPAGLGGGL--SWRAGW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 162 LFLIIVSIIVGFLMMIYLPKDQEIQRGPVNHETPSHENHVTSKI--LRPAEVAKYLI-ITFLVLIANSVTFVFINPlils 238
Cdd:cd06180 158 LALALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNRPLWRLalAYGLFGFGYIItATFLPLIARETGAGSLLA---- 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1468255991 239 nGHDMSFVslallvnGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGL 305
Cdd:cd06180 234 -GLLWSLF-------GLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAV 292
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
32-279 |
4.96e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.90 E-value: 4.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 32 QDLHVSEAVVGQLVTMYALT-FAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALII 110
Cdd:cd17490 24 ESLGASLSMIGIILGAYGISqMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 111 VKVLAITAMLSaPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSIIvGFLMMIYLpKDQEIQRGPV 190
Cdd:cd17490 104 SFTVLYASYFP-PDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVL-GFILSLFI-KEERREKKPV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 191 NHEtpshenhvTSKILRPAEVAKYLIITFLVLIANSVTFVFI---NPLILSN-GHDMSFVSLALLVNGIAGVIGTSLGGI 266
Cdd:cd17490 181 LTE--------LKELLSVLKDKKLLFFSLLAILQQMITFSTTfgfTPLIAKQlGASSFQLGLLSIIYLLPNALASLLSGT 252
|
250
....*....|...
gi 1468255991 267 FSDKITSKRWLMI 279
Cdd:cd17490 253 LFYKKLGERNTII 265
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
6-184 |
5.17e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 5.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNL-MSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNG 84
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYyFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 85 IIAVAP--NFSILVVGRIISSAAAALIIVKVLAITAML---SAPKNRGKMIGLVYTGFSGANVFGVPIGTVIG------- 152
Cdd:COG2211 310 LLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVvdyDEWKTGRRREGLYFGIFTFAIKLGQALAGALAglllalf 389
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1468255991 153 -----------DLVGWRYTFLFLIIVSIIVGFLMMIYLPKDQE 184
Cdd:COG2211 390 gyvagaaqspsALTGIRLLFFLLPAVLLLLAALLLLFYPLTRE 432
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
23-177 |
6.20e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 44.87 E-value: 6.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 23 VAGIMNLMSQDLHVSEAVVGQ-LVTMYALTFAICGPILV-KLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRI 100
Cdd:cd17315 16 INGALLYIAKDLGFGLSTSLQgLVVSSLLLGAAIGSLFGgPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 101 ISSAAAALIIVKVLAITAMLSAPKNRGKMIGL----VYTGFSGANVFGVPIGTVIGDlvGWRYTFLFLIIVSIIVGFLMM 176
Cdd:cd17315 96 LLGLGVGLASVLVPLYISEIAPAKIRGALGTLnqlmITFGILLAYLLGLALSLSPPG--WWRLMFALAAVPALLQLLLMF 173
|
.
gi 1468255991 177 I 177
Cdd:cd17315 174 F 174
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
10-151 |
1.69e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 43.32 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 10 ILSIFIVGMVEMMVAGIMNLMSQD-LHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAV 88
Cdd:cd17321 174 VLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL 253
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1468255991 89 APN---FSILVVGRIISSAAAALIIVkVLAITAMLSAPKNRGKMI-GLVYTGFSGANVFGVPIGTVI 151
Cdd:cd17321 254 LGAdssVWLLLPGLVLLGLGLGLFAT-PLTNAALSSVPKEKAGAAsGILNTARQLGGALGVALLGAL 319
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
46-181 |
1.79e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.95 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 46 TMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKN 125
Cdd:cd17317 32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1468255991 126 RGKMIGLVYTGFSGANVFGVPIGTVIGDlvgWRYtFLFLIIVSIIVGFLMMIYLPK 181
Cdd:cd17317 112 RSFVGILFGLFWALGYMLLALLAYLIRD---WRW-LQLAISLPGLLFLLLLWWLPR 163
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
32-302 |
2.19e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 43.03 E-value: 2.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 32 QDLHVSEAVVGQLVTMyaltfAICGPilvkLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALIIV 111
Cdd:cd17360 37 QELIVSSTVAGAAVGA-----AIGGW----LNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASM 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 112 KVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDL-VGWRYTFLFLIIVSIIVGFLMMiYLPkdqeiqrgpv 190
Cdd:cd17360 108 TVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLpGGWRWMLGLAAVPAVLQFIGLL-FLP---------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 191 nhETPshenhvtskilRPAEVAKYLIITFLVLIANSV----TFVFINPLIL--SNGHDMSFVSLALLVNGIAGVIGTSLG 264
Cdd:cd17360 177 --ESP-----------RWPSTRRALIVGCGLQAFQQFsginTVMYYSATILqmAGFKDNQNAIWLSLIVAGTNFIFTIVG 243
|
250 260 270
....*....|....*....|....*....|....*...
gi 1468255991 265 GIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLL 302
Cdd:cd17360 244 MYLIDKFGRRKLLLISLFGVIVALVVLAVWLALVGLIL 281
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
11-177 |
2.27e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.98 E-value: 2.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 11 LSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQL-VTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGN-GIIAV 88
Cdd:cd17353 220 LMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALaVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMfLLPFI 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 89 APNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVS 168
Cdd:cd17353 300 GSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALS 379
|
....*....
gi 1468255991 169 IIVGFLMMI 177
Cdd:cd17353 380 LVALALALL 388
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
5-307 |
2.28e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 43.03 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 5 RLFTFILSIFIVGM---VEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFII 81
Cdd:cd17312 1 RWRIFLGVFLGYAAyyvCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 82 GNGIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTF 161
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 162 LFLIIVSIIVGFLMMIYLpkdqeiqrgpvnHETPSHenhvtskilrpaeVAKYLIITFLVLIANSvTFVFINPLILSNGH 241
Cdd:cd17312 161 LVPGIVGLVVAIILFFFL------------RDSPPY-------------VWVLSLAYAFVYIVRY-ACLDWGPLYLYEVK 214
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1468255991 242 DMSFVSLALLV--NGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSG--------LLLAGLFI 307
Cdd:cd17312 215 GYSLIDAGWFSslYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHnkllsivlLFLIGFFV 290
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
6-307 |
2.52e-04 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 42.78 E-value: 2.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGI 85
Cdd:cd17314 5 LYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 86 IAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLI 165
Cdd:cd17314 85 LSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 166 IVSIIVGFLMMIYLPKDQeiQRGPVNHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVFINPLI-LSNGHDMS 244
Cdd:cd17314 165 ILAAIVLSVVSLLGFKEP--PDNQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVrSLQLDAPS 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1468255991 245 FVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFI 307
Cdd:cd17314 243 FVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTG 305
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
41-195 |
3.89e-04 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 42.17 E-value: 3.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 41 VGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAML 120
Cdd:cd17384 33 VGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASL 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1468255991 121 -SAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSIIVGFLMMIYLPKdqEIQRGPVNHETP 195
Cdd:cd17384 113 yPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQP--SVKSEESEEGTP 186
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
5-174 |
4.86e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.03 E-value: 4.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 5 RLFTFILSIFIVGMVEMMVAGIMN-LMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWT-LLIFIIG 82
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPlFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIgLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 83 NGIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLV-GWRYTF 161
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATfGLTGAF 363
|
170
....*....|...
gi 1468255991 162 LFLIIVSIIVGFL 174
Cdd:cd06174 364 LVLAVLLLLAAIL 376
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
53-240 |
5.79e-04 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 41.91 E-value: 5.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 53 AICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGL 132
Cdd:cd17322 51 AVSQPPYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGFASAI 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 133 VYTGFSGANVFGVPIGTVIGDLVGWRYTF-LFLII---VSIIVGFLMMIYLPKdqeIQRGPVNHETPSHENHVTSKILR- 207
Cdd:cd17322 131 PSLPYIITTWIGGNIAQAALPNSNWRWGYgMWAIIlplSSLPLVLCLLYMQRK---ARKDGEIKELKNQETEEQTGGLSq 207
|
170 180 190
....*....|....*....|....*....|....
gi 1468255991 208 -PAEVAKYLIITFLVLIANSVTFVFInPLILSNG 240
Cdd:cd17322 208 nLVKLFWKLDIFGVILLTAGLGLILV-PLTLAGG 240
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
32-231 |
5.97e-04 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 41.96 E-value: 5.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 32 QDLHVSEAVvGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALIIV 111
Cdd:pfam06609 72 QDIGQSENQ-GLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGPAGA 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 112 KVLAITAMLSapkNRGKMIGLVYTGFS--GANVFGVPIGTVIGDLVGWRYTFLFLIIVSIIVGFLMMIYlpkdqeiqrgp 189
Cdd:pfam06609 151 SPLFIGELMS---NKTKFLGLLIVSAPtiAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIW----------- 216
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1468255991 190 vnHETPSHENHVTSKILRPAEVAKYLIITFLVLIANSVTFVF 231
Cdd:pfam06609 217 --YHPPSFAQLHGKKARKRDELAKLDWIGIFLVIAGTSLFLL 256
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
62-307 |
1.07e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 40.72 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 62 LTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTgfsgan 141
Cdd:PRK11551 73 LADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYC------ 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 142 vfGVPIGTVIGDLVG--------WRYTFLFLIIVSIIVGFLMMIYLPKDQE-IQRGPVNHETPSHENHVTSKILRPAEVA 212
Cdd:PRK11551 147 --GVPFGGALASVIGvlaagdaaWRHIFYVGGVGPLLLVPLLMRWLPESRAfAQAAGAGKQRAPVLRALFGEGRATATLL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 213 KYlIITFLVLIansVTFVFIN---PLILSNGHDMSFVSLALLVNGIAGVIGTSLGGIFSDKItskRWLMISVSIF--IVM 287
Cdd:PRK11551 225 LW-ISYFFTLI---VLYFLLNwlpSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRL---RPRRVVLLIYagILA 297
|
250 260
....*....|....*....|....*
gi 1468255991 288 MLLMNLILPGSGLLL-----AGLFI 307
Cdd:PRK11551 298 SLAALAAAPSFAGMLlagfaAGLFV 322
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
54-181 |
2.74e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 39.58 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 54 ICGPilvkLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLV 133
Cdd:cd17374 54 IFGH----LSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLT 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1468255991 134 YTGFSGANVFGVPIGTVIGDlvgWRYTFLfLIIVSIIVGFLMMIYLPK 181
Cdd:cd17374 130 SCFFSIGQMLLAGLAYAIRD---WRLLQL-VVSVPFFLFFLYSWWLPK 173
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
215-395 |
3.01e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.32 E-value: 3.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 215 LIITFLVLIANSVTFVFINPLILSN-GHDMSFVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMnL 293
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL-L 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 294 ILPGSGLLLAGLFIWNIMQWSTNPAVQSGVIQHV-EGDTSQVMSWNMSSLNAGIGVGGIIGGLVMTHVSVQAITYTSAII 372
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180
....*....|....*....|...
gi 1468255991 373 GALGLIVAFTLKNNHYAKTFKSS 395
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPA 183
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
56-186 |
5.17e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 38.91 E-value: 5.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 56 GPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRII----------SSAAaaliivkvlaiTAMLSAPKN 125
Cdd:PRK03893 72 GLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVigmgmageygSSAT-----------YVIESWPKH 140
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1468255991 126 -RGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFlFLIIVSIIVGFLMMIYLPKDQEIQ 186
Cdd:PRK03893 141 lRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALF-FIGILPIIFALWLRKNLPEAEDWK 201
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
26-302 |
5.69e-03 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 38.63 E-value: 5.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 26 IMNLMSQDLHVSEAVVGQLVtMYALTFAICGPILVkltNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAA 105
Cdd:cd17435 27 LRTLLALSCHEQEMVVSSLL-IGALLASLTGGVLI---DRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVS 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 106 AALIIVKVLAITAMLSAPKNRGKMIGL----VYTGFSGANVFGVPIGTVIGdlvGWRYTFlFLIIVSIIVGFLMMIYLPk 181
Cdd:cd17435 103 ISLSSIATCVYIAEIAPQHRRGLLVSLnelmIVIGILLAYISNYAFANVSN---GWKYMF-GLVIPLAALQAIAMYFLP- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 182 dqeiqrgpvnhetPSHENHVTSKILRpAEVAKYLIITFLVLIANSVTFVFINPLILSN--GHDMSFVSLALLVNGIAGVI 259
Cdd:cd17435 178 -------------PSPRFLVMKDNMR-ARLLIGLTLVFFVQITGQPNILFYASTVLKSvgFQSNEAASLASTGVGVVKVV 243
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1468255991 260 GTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLL 302
Cdd:cd17435 244 STIPAIFLVDKVGSKTFLCIGSSVMAVSLVTMGLWLSLASLLV 286
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
6-304 |
5.70e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 38.39 E-value: 5.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 6 LFTFILSIFIVGMVEMMVAGIMNLMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGN-G 84
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLlA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 85 IIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSapknrGKMIGLVYTGFSGANVFGVPIGTVI-----------GD 153
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFP-----KEKIGGAAGGIAGAGNMGVAVSQLLapliagaivfdGG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 154 LVGWRYTFLFLIIVSIIVGFLMMIyLPKDQEIQRGPVNHETPSHENHVTSKilRPAEVAKYLIITFLVLIANSVTFvfin 233
Cdd:cd17341 156 FVGWRNAFFVPGILLAIAAVLVLL-FGDDLPTGKASALEFLKVQLAVLKNY--RTWILSLLYGVTFGSFVGFSNVL---- 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1468255991 234 PLILSNGHDMSFVSLALL--VNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAG 304
Cdd:cd17341 229 PTYFKTRFGLPLVTAGILaaLFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVL 301
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
62-295 |
5.80e-03 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 38.39 E-value: 5.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 62 LTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIglvyTGFSGAN 141
Cdd:cd17361 74 VTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALN----IGFQLAI 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 142 VFGVPIGTVIGDLV------GWRYTfLFLIIVSIIVGFLMMIYLPkdqeiqrgpvnhETPShenhvtskilRPAEVAKYL 215
Cdd:cd17361 150 TIGILIANLINYGTskikpnGWRLS-LGLAAVPALILLLGSLFLP------------ETPN----------SPQLVIAIL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 216 IITFLVLIANSVTFVFINPLILSNGHDMSFVSLALLVNGIAGVIGTSLGGIFSDKITSKRWLMISVSIFIVMMLLMNLIL 295
Cdd:cd17361 207 IPFFQQLTGINVIMFYAPVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFLLLEGGVQMLASQVAIGILL 286
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
29-308 |
6.80e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 38.37 E-value: 6.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 29 LMSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIfiIGNGIIAVAPNFSILVVGRIISSAAAAL 108
Cdd:cd17475 21 FLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLL--MGAAALLMALVGSYPVLLVLLFLVGAGY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 109 IIVKVLAITAMLS--APKNRGKMIGLVYTGfsganvfgVPIGTVIGDLV--------GWRYTFLFLIIVSIIVGFLMMIY 178
Cdd:cd17475 99 GSVQPGGGRAIMRwfPPRERGLAMGIRQTG--------VPLGGALAAALlpplalhyGWRAAFVVAGLVSILAAVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 179 LPKDQEIQRGPvnhETPSHENHVTSKILRPAEVAKYLIITFLvLIANSVTFVFINPLILSNGHDMSFV--SLALLVNGIA 256
Cdd:cd17475 171 YREPPAASAAT---ESASTLLRSLKEVLRNRDVWLIAIAGAL-LVAPQFALLTFLLLFLHDHLGLSVVaaGALLAVAQLG 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1468255991 257 GVIGTSLGGIFSDKITS---KRWLMISVSIFIVMMLLMNLILPGS-GLLLAGLFIW 308
Cdd:cd17475 247 GALGRIGLGRVSDRVFGgrrRPVLVITAAIAAAALLVLSLLSPGTpLWLLVLLLIL 302
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
138-313 |
7.97e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 37.98 E-value: 7.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 138 SGANVFGVPIGTVIG--------DLVGWRYTFLFLIIVSIIVgfLMMIYLPKDQEIQRGPVNHETPSHENHVTSKILRPA 209
Cdd:cd17485 130 NAAQVVGYKLGSLLGgggllwlyDLIGWQSLLLSLAALYLLL--LLPVLFLRELELPQQPPASERGAALKASLRAFLRRP 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 210 EVAKYLIITFLVLIANSVTFVFINPLILSNGHDMSFVSLALLVNG-IAGVIGTSLGGIFSDKITSKRWLMI-SVSIFIVM 287
Cdd:cd17485 208 GTRWLLLFLLLYKLGEQGALAMLPPFLVDRGFSLSQIGLLSGVGGsLVSIAGSLLGGYLLKRRGRRRLLLLgGLLRLLLL 287
|
170 180
....*....|....*....|....*.
gi 1468255991 288 MLLMNLILPGSGLLLAGLFIWNIMQW 313
Cdd:cd17485 288 GLYTLLALGGSGLNWVLLLASLALLH 313
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
4-176 |
8.16e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 37.91 E-value: 8.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 4 MRLFTFILSIFIVGMVEMMvaGIMNL---MSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFI 80
Cdd:cd17471 199 RRLLLLFAAFTLLFAANSM--YIIAMplyVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGV 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 81 IGNGIIAVAPNFSILVVGRIISsaAAALIIVKVLAITAMLS-APKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRY 159
Cdd:cd17471 277 LFYLGLALATSLWQLIALQLLN--AIFIGITAGLGISYFQDlMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRA 354
|
170
....*....|....*..
gi 1468255991 160 TFLFLIIVSIIVGFLMM 176
Cdd:cd17471 355 VFLVCAVLALLALVLLL 371
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
62-180 |
8.40e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 37.98 E-value: 8.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 62 LTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSI--LVVGRIISSAAAALIIVKVLAITAMLSAPKNRGKMIGLVYTGFSG 139
Cdd:cd17318 79 LAEKYGAKRVLGYSILITALLTLLTPLAARGGYgaLIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQF 158
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1468255991 140 ANVFGVPIGTVIGDLVGWRYTFLFLIIVSIIVGFLMMIYLP 180
Cdd:cd17318 159 GTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
13-181 |
9.00e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 37.98 E-value: 9.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 13 IFIVGMVEMM-VAGIMNLMS---QDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAV 88
Cdd:cd17390 1 LYLVGFLDLFgVSMILPLLSthiRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 89 APNFSILVVGRIISSA-AAALIIVKvlAITAMLSAPKNRGKMIGLvytgFSGANVFGVPIGTVIGDLV-----GWRYTFL 162
Cdd:cd17390 81 STSLALLFLSRIPLGIfKHTQSLCK--AYLSDLVSEQERSRVLGR----FNAASSLGFILGPVVGGHLaetdgGFYYVAL 154
|
170
....*....|....*....
gi 1468255991 163 FLIIVSIIVGFLMMIYLPK 181
Cdd:cd17390 155 LCSAIFILNAGLVWFLLSK 173
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
30-379 |
9.30e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 37.97 E-value: 9.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 30 MSQDLHVSEAVVGQLVTMYALTFAICGPILVKLTNRFSSRPVLLWTLLIFIIGNGIIAVAPNFSILVVGR-IISSAAAAL 108
Cdd:cd17353 29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYgVLGGIGAGI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 109 IIVKVLAiTAMLSAPKNRGKMIGLVYTGFSGANVFGVPIGTVIGDLVGWRYTFLFLIIVSIIVGFLMMIYL----PKDQE 184
Cdd:cd17353 109 GYITPVS-TAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIrdppKGWVP 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 185 IQRGPVNHETPSHENHVT-SKILRPAEVAKYLIITFLVLIANSVTFVFINPLILS-NGHDMSFVSLALLVNGIAGVIGTS 262
Cdd:cd17353 188 PGVDPLANNAENSPRDYTpREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEfAGLDAGIAALAVSILSIFNGGGRP 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468255991 263 LGGIFSDKITSKRWLMISVSIFIVMMLLMNLILPGSGLLLAGLFIWNIMqWSTNPAVQSGVIQHVEGDTSQvmSWNMSSL 342
Cdd:cd17353 268 FWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFC-YGGGFALFPALTADFFGTKNA--GTNYGLL 344
|
330 340 350
....*....|....*....|....*....|....*..
gi 1468255991 343 NAGIGVGGIIGGLVMTHVsVQAITYTSAIIGALGLIV 379
Cdd:cd17353 345 YTAKGVGGLIGPIIAAYV-LYTGGYNAAFIIAAALSL 380
|
|
| |
