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Conserved domains on  [gi|1468704630|ref|WP_117576703|]
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AraC family transcriptional regulator [Faecalimonas umbilicata]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 15746445)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  2.60.120.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  11282467|33837749|9409145|12270809|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
311-391 3.90e-21

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.84  E-value: 3.90e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630  311 MEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAATERSVTQIGQNVGFGSISTFQRSFQKYMNQTPSEY 390
Cdd:smart00342   4 LEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEY 83


                   .
gi 1468704630  391 R 391
Cdd:smart00342  84 R 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
196-281 2.32e-12

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


:

Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 66.73  E-value: 2.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 196 LSLEEYAKAAGMTAVTLNRHITKNCGYTFFQLQKMGKVFHACALLHFPDLDLQYISDYLGFTNLEDFCRVFKRYMKMSVR 275
Cdd:COG2207   169 LTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPS 248


                  ....*.
gi 1468704630 276 EYQTQH 281
Cdd:COG2207   249 EYRKRL 254
ManC super family cl43229
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
37-67 1.06e-03

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG0662:

Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 38.58  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1468704630  37 HERTEIYYVRSGKATIWVNGEKFKVRQGSLL 67
Cdd:COG0662    46 PHRDEFFYVLEGTGEVTIGDEEVELKAGDSV 76
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
311-391 3.90e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.84  E-value: 3.90e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630  311 MEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAATERSVTQIGQNVGFGSISTFQRSFQKYMNQTPSEY 390
Cdd:smart00342   4 LEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEY 83


                   .
gi 1468704630  391 R 391
Cdd:smart00342  84 R 84
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 278-395 1.44e-20

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 91.37  E-value: 1.44e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 278 QTQHIGAGVGMRGEEEALQ-VLQYLLLCFHKPFQMEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAAT 356
Cdd:COG4977   195 QAQFSPLLVPLGHRDPRLArAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETT 274

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1468704630 357 ERSVTQIGQNVGFGSISTFQRSFQKYMNQTPSEYRSEYR 395
Cdd:COG4977   275 DLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFR 313
HTH_18 pfam12833
Helix-turn-helix domain;
314-391 2.91e-15

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 70.31  E-value: 2.91e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1468704630 314 MAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLA-ATERSVTQIGQNVGFGSISTFQRSFQKYMNQTPSEYR 391
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLeDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
196-281 2.32e-12

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 66.73  E-value: 2.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 196 LSLEEYAKAAGMTAVTLNRHITKNCGYTFFQLQKMGKVFHACALLHFPDLDLQYISDYLGFTNLEDFCRVFKRYMKMSVR 275
Cdd:COG2207   169 LTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPS 248


                  ....*.
gi 1468704630 276 EYQTQH 281
Cdd:COG2207   249 EYRKRL 254
HTH_18 pfam12833
Helix-turn-helix domain;
201-280 5.09e-11

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 58.37  E-value: 5.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 201 YAKAAGMTAVTLNRHITKNCGYTFFQLQKMGKVFHACALL-HFPDLDLQYISDYLGFTNLEDFCRVFKRYMKMSVREYQT 279
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1468704630 280 Q 280
Cdd:pfam12833  81 R 81
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
196-277 6.50e-10

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 55.25  E-value: 6.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630  196 LSLEEYAKAAGMTAVTLNRHITKNCGYTFFQLQKMGKVFHACALLHFPDLDLQYISDYLGFTNLEDFCRVFKRYMKMSVR 275
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ..
gi 1468704630  276 EY 277
Cdd:smart00342  82 EY 83
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
295-395 3.38e-08

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 54.59  E-value: 3.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 295 LQVLQYLLLCFHKPFQMEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAATERSVTQIGQNVGFGSIST 374
Cdd:PRK10572  186 REACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLY 265

                          90       100
                  ....*....|....*....|.
gi 1468704630 375 FQRSFQKYMNQTPSEYRSEYR 395
Cdd:PRK10572  266 FSRVFKKCTGASPSEFRARCE 286
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
37-67 1.06e-03

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 38.58  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1468704630  37 HERTEIYYVRSGKATIWVNGEKFKVRQGSLL 67
Cdd:COG0662    46 PHRDEFFYVLEGTGEVTIGDEEVELKAGDSV 76
cupin_MJ1618 cd02214
Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain; This family includes ...
 36-64 4.00e-03

Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain; This family includes bacterial and archaeal proteins homologous to MJ1618, a Methanocaldococcus jannaschii protein of unknown function with a cupin beta barrel domain. The active site of members of the cupin superfamily is generally located at the center of a conserved barrel and usually includes a metal ion.


Pssm-ID: 380344 [Multi-domain]  Cd Length: 100  Bit Score: 36.34  E-value: 4.00e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1468704630  36 FHERT-EIYYVRSGKATIWVNGEKFKVRQG 64
Cdd:cd02214    36 RLKGSeEVYYILEGEGTMEIDGEPREVGPG 65
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 37-67 4.42e-03

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 35.70  E-value: 4.42e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1468704630  37 HER-TEIYYVRSGKATIWVNGEKFKVRQGSLL 67
Cdd:pfam07883  16 HPGeDEFFYVLEGEGELTVDGEEVVLKAGDSV 47
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
311-391 3.90e-21

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.84  E-value: 3.90e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630  311 MEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAATERSVTQIGQNVGFGSISTFQRSFQKYMNQTPSEY 390
Cdd:smart00342   4 LEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEY 83


                   .
gi 1468704630  391 R 391
Cdd:smart00342  84 R 84
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 278-395 1.44e-20

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 91.37  E-value: 1.44e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 278 QTQHIGAGVGMRGEEEALQ-VLQYLLLCFHKPFQMEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAAT 356
Cdd:COG4977   195 QAQFSPLLVPLGHRDPRLArAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETT 274

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1468704630 357 ERSVTQIGQNVGFGSISTFQRSFQKYMNQTPSEYRSEYR 395
Cdd:COG4977   275 DLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAYRRRFR 313
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
289-395 1.02e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 82.14  E-value: 1.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 289 RGEEEALQVLQYLLLCFHKPFQMEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAATERSVTQIGQNVG 368
Cdd:COG2207   149 LLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELG 228

                          90       100
                  ....*....|....*....|....*..
gi 1468704630 369 FGSISTFQRSFQKYMNQTPSEYRSEYR 395
Cdd:COG2207   229 FSSQSHFSRAFKKRFGVTPSEYRKRLR 255
HTH_18 pfam12833
Helix-turn-helix domain;
314-391 2.91e-15

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 70.31  E-value: 2.91e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1468704630 314 MAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLA-ATERSVTQIGQNVGFGSISTFQRSFQKYMNQTPSEYR 391
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLeDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
196-281 2.32e-12

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 66.73  E-value: 2.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 196 LSLEEYAKAAGMTAVTLNRHITKNCGYTFFQLQKMGKVFHACALLHFPDLDLQYISDYLGFTNLEDFCRVFKRYMKMSVR 275
Cdd:COG2207   169 LTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPS 248


                  ....*.
gi 1468704630 276 EYQTQH 281
Cdd:COG2207   249 EYRKRL 254
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 289-391 1.42e-11

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 65.07  E-value: 1.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 289 RGEEEALQVLQYLLLCFHKPFQMEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAaTERSVTQIGQNVG 368
Cdd:COG2169    81 PRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQ-TGLSVTDAAYAAG 159

                          90       100
                  ....*....|....*....|...
gi 1468704630 369 FGSISTFQRSFQKYMNQTPSEYR 391
Cdd:COG2169   160 FGSLSRFYEAFKKLLGMTPSAYR 182
HTH_18 pfam12833
Helix-turn-helix domain;
201-280 5.09e-11

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 58.37  E-value: 5.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 201 YAKAAGMTAVTLNRHITKNCGYTFFQLQKMGKVFHACALL-HFPDLDLQYISDYLGFTNLEDFCRVFKRYMKMSVREYQT 279
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1468704630 280 Q 280
Cdd:pfam12833  81 R 81
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
196-277 6.50e-10

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 55.25  E-value: 6.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630  196 LSLEEYAKAAGMTAVTLNRHITKNCGYTFFQLQKMGKVFHACALLHFPDLDLQYISDYLGFTNLEDFCRVFKRYMKMSVR 275
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ..
gi 1468704630  276 EY 277
Cdd:smart00342  82 EY 83
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
295-395 3.38e-08

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 54.59  E-value: 3.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 295 LQVLQYLLLCFHKPFQMEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAATERSVTQIGQNVGFGSIST 374
Cdd:PRK10572  186 REACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLY 265

                          90       100
                  ....*....|....*....|.
gi 1468704630 375 FQRSFQKYMNQTPSEYRSEYR 395
Cdd:PRK10572  266 FSRVFKKCTGASPSEFRARCE 286
ftrA PRK09393
transcriptional activator FtrA; Provisional
 278-395 5.51e-08

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 54.20  E-value: 5.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 278 QTQHIGAGVGMRGEEEALQVLQYLLLCFHKPFQMEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAATE 357
Cdd:PRK09393  204 QAQFVPRPVASRESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSA 283

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1468704630 358 RSVTQIGQNVGFGSISTFQRSFQKYMNQTPSEYRSEYR 395
Cdd:PRK09393  284 LSIDQIAERAGFGSEESLRHHFRRRAATSPAAYRKRFG 321
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
307-391 5.60e-07

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 47.61  E-value: 5.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 307 KPFQMEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAATERSVTQIGQNVGFGSISTFQRSFQKYMNQT 386
Cdd:PRK10219   20 QPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRT 99


                  ....*
gi 1468704630 387 PSEYR 391
Cdd:PRK10219  100 PSDYR 104
PRK10371 PRK10371
transcriptional regulator MelR;
296-391 6.18e-06

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 47.51  E-value: 6.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 296 QVLQYLLLCFHKPFQMEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAATERSVTQIGQNVGFGSISTF 375
Cdd:PRK10371  195 QMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRF 274

                          90
                  ....*....|....*.
gi 1468704630 376 QRSFQKYMNQTPSEYR 391
Cdd:PRK10371  275 YSTFGKYVGMSPQQYR 290
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 354-391 9.17e-06

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 42.14  E-value: 9.17e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1468704630 354 AATERSVTQIGQNVGFgSISTFQRSFQKYMNQTPSEYR 391
Cdd:pfam00165   5 LSTNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYR 41
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 196-281 1.93e-05

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 46.30  E-value: 1.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 196 LSLEEYAKAAGMTAVTLNRHITKNCGYTFFQ-LQKMgKVFHACALLHFPDLDLQYISDYLGFTNLEDFCRVFKRYMKMSV 274
Cdd:COG4977   227 LSVDELARRAGMSPRTLERRFRAATGTTPARyLQRL-RLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSP 305


                  ....*..
gi 1468704630 275 REYQTQH 281
Cdd:COG4977   306 SAYRRRF 312
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 314-391 3.80e-05

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 44.92  E-value: 3.80e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1468704630 314 MAQQLKMKPFQMEKRSREQfGRTVQELLEEIRVRMACSYLAATERSVTQIGQNVGFGSISTFQRSFQKYMNQTPSEYR 391
Cdd:PRK09978  164 IASELLMSPSLLKKKLREE-ETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEYQ 240
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 329-391 3.20e-04

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 42.05  E-value: 3.20e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1468704630 329 SREQFGRTVQELLEEIRVRMACSYLAATERSVTQIGQNVGFGSISTFQRSFQKYMNQTPSEYR 391
Cdd:PRK10296  209 TRRYYGKTPMQIINEIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYR 271
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
305-391 5.57e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 41.58  E-value: 5.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 305 FHKPFQMEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAATERSVTQIGQNVGFGSISTFQRSFQKYMN 384
Cdd:PRK13502  189 LECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETG 268


                  ....*..
gi 1468704630 385 QTPSEYR 391
Cdd:PRK13502  269 MTPSQWR 275
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
37-67 1.06e-03

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 38.58  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1468704630  37 HERTEIYYVRSGKATIWVNGEKFKVRQGSLL 67
Cdd:COG0662    46 PHRDEFFYVLEGTGEVTIGDEEVELKAGDSV 76
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 354-395 2.60e-03

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 39.63  E-value: 2.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1468704630 354 AATERSVTQIGQNVGFGSISTFQRSFQKYMNQTPSEYRSEYR 395
Cdd:PRK09685  261 AADDEKITSIAYKWGFSDSSHFSTAFKQRFGVSPGEYRRKFR 302
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
37-67 3.23e-03

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 36.75  E-value: 3.23e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1468704630  37 HERTEIYYVRSGKATIWVNGEKFKVRQGSLL 67
Cdd:COG1917    41 HPGEELIYVLEGEGEVEVGGEEYELKPGDVV 71
cupin_MJ1618 cd02214
Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain; This family includes ...
 36-64 4.00e-03

Methanocaldococcus jannaschii MJ1618 and related proteins, cupin domain; This family includes bacterial and archaeal proteins homologous to MJ1618, a Methanocaldococcus jannaschii protein of unknown function with a cupin beta barrel domain. The active site of members of the cupin superfamily is generally located at the center of a conserved barrel and usually includes a metal ion.


Pssm-ID: 380344 [Multi-domain]  Cd Length: 100  Bit Score: 36.34  E-value: 4.00e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1468704630  36 FHERT-EIYYVRSGKATIWVNGEKFKVRQG 64
Cdd:cd02214    36 RLKGSeEVYYILEGEGTMEIDGEPREVGPG 65
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
296-391 4.40e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 38.93  E-value: 4.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1468704630 296 QVLQYLLLCFHKPFQMEEMAQQLKMKPFQMEKRSREQFGRTVQELLEEIRVRMACSYLAATERSVTQIGQNVGFGSISTF 375
Cdd:PRK13500  210 KLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYF 289

                          90
                  ....*....|....*.
gi 1468704630 376 QRSFQKYMNQTPSEYR 391
Cdd:PRK13500  290 SVVFTRETGMTPSQWR 305
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 37-67 4.42e-03

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 35.70  E-value: 4.42e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1468704630  37 HER-TEIYYVRSGKATIWVNGEKFKVRQGSLL 67
Cdd:pfam07883  16 HPGeDEFFYVLEGEGELTVDGEEVVLKAGDSV 47
cupin_Pac13-like cd20295
monomeric dehydratase Pac13 and related proteins, cupin domain; This family includes a small ...
 13-66 9.42e-03

monomeric dehydratase Pac13 and related proteins, cupin domain; This family includes a small monomeric dehydratase Pac13 that mediates the formation of the 3'-deoxynucleotide of pacidamycins, which are uradyl peptide antibiotics (UPAs). Pac13 is involved in the formation of the unique 3'-deoxyuridine moiety found in these UPAs; it catalyzes the dehydration of uridine-5'-aldehyde. The similarity of the 3'-deoxy pacidamycin moiety with synthetic anti-retrovirals, offers a potential opportunity for the utilization of Pac13 in the biocatalytic generation of antiviral compounds. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380429 [Multi-domain]  Cd Length: 101  Bit Score: 35.66  E-value: 9.42e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1468704630  13 YYNFRERQISVQELCIINPVEQVFHER-TEIYYVRSGKATIWVNGEKFKVRQGSL 66
Cdd:cd20295    14 FYDQDDPPASVHLVEVEEGHEEHYHKKsTEIYYVLEGEGIFELDGEAVPVKPGDL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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