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Conserved domains on  [gi|1469306857|ref|WP_117648303|]
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MULTISPECIES: anti-sigma factor antagonist [unclassified Collinsella]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 5-95 8.28e-23

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


:

Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 89.12  E-value: 8.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   5 NDIAVLTPPGDIDIATVPALRRRLDALIGRGVRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGEVVRFL 84
Cdd:cd07043     7 GGVLVVRLSGELDAATAPELREALEELLAEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSPAVRRVL 86

                          90
                  ....*....|.
gi 1469306857  85 EIARLVDILHV 95
Cdd:cd07043    87 ELTGLDRLFPI 97
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
117-238 1.49e-21

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


:

Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 86.51  E-value: 1.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857 117 SVEVRQGIENLPYYRHRIAELLESLPLRRDERYDVALASGEALGNAYDHAGG---IGCV-LTVQAYGDRVVVEVLDRGAG 192
Cdd:COG2172     1 SLSLPADLEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGgdpDGPVeVELELDPDGLEIEVRDEGPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1469306857 193 YSIDETSEPVASE-ERGRGIKLMRMLVDNVEVarRTDGAGTRVQMVK 238
Cdd:COG2172    81 FDPEDLPDPYSTLaEGGRGLFLIRRLMDEVEY--ESDPGGTTVRLVK 125
 
Name Accession Description Interval E-value
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 5-95 8.28e-23

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 89.12  E-value: 8.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   5 NDIAVLTPPGDIDIATVPALRRRLDALIGRGVRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGEVVRFL 84
Cdd:cd07043     7 GGVLVVRLSGELDAATAPELREALEELLAEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSPAVRRVL 86

                          90
                  ....*....|.
gi 1469306857  85 EIARLVDILHV 95
Cdd:cd07043    87 ELTGLDRLFPI 97
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
117-238 1.49e-21

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 86.51  E-value: 1.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857 117 SVEVRQGIENLPYYRHRIAELLESLPLRRDERYDVALASGEALGNAYDHAGG---IGCV-LTVQAYGDRVVVEVLDRGAG 192
Cdd:COG2172     1 SLSLPADLEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGgdpDGPVeVELELDPDGLEIEVRDEGPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1469306857 193 YSIDETSEPVASE-ERGRGIKLMRMLVDNVEVarRTDGAGTRVQMVK 238
Cdd:COG2172    81 FDPEDLPDPYSTLaEGGRGLFLIRRLMDEVEY--ESDPGGTTVRLVK 125
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 3-89 9.25e-20

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 81.05  E-value: 9.25e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   3 EWNDIAVLTPPGDIDIATVPALRRRLDALIGRGVRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGEVVR 82
Cdd:COG1366     6 VRDGVLVLPLIGELDAARAPELREALLEALETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPAVAR 85


                  ....*..
gi 1469306857  83 FLEIARL 89
Cdd:COG1366    86 VLELTGL 92
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
 1-96 6.06e-19

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 79.18  E-value: 6.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   1 MNEWNDIAVLTPPGDIDIATVPALRRRLDALI-GRGVRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGE 79
Cdd:TIGR00377   7 TEVQEGVVVVRLSGELDAHTAPLLREKVTPAAeRTGIRPIVLDLEDLEFMDSSGLGVLLGRYKQVRRVGGQLVLVSVSPR 86

                          90
                  ....*....|....*..
gi 1469306857  80 VVRFLEIARLVDILHVA 96
Cdd:TIGR00377  87 VARLLDITGLLRIIPIY 103
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 5-95 2.38e-16

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 72.26  E-value: 2.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   5 NDIAVLTPPGDIDIATVPALRRRLDALIGRG-VRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGEVVRF 83
Cdd:pfam01740   8 PGILILRLDGPLDFANAESLRERLLRALEEGeIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPEVART 87

                          90
                  ....*....|..
gi 1469306857  84 LEIARLVDILHV 95
Cdd:pfam01740  88 LEKTGLDDIIKI 99
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
131-238 5.29e-14

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 66.54  E-value: 5.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857 131 RHRIAELLESLPLRRDERYDVALASGEALGNAYDHAGGIG----CVLTVQAYGDRVVVEVLDRGAGYSIDETSEPVASE- 205
Cdd:pfam13581  12 RRVLEAVLRRAGLPEELLDEVELAVGEACTNAVEHAYREGpegpVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDLEEp 91

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1469306857 206 -----ERGRGIKLMRMLVDNVEVARrtDGAGTRVQMVK 238
Cdd:pfam13581  92 dedrkEGGRGLALIRGLMDDVEYTR--GGEGNTVRMRK 127
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 151-238 1.78e-13

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 64.21  E-value: 1.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857 151 VALASGEALGNAYDHA----GGIGCVLTVQAYGDRVVVEVLDRGAGYSIDETSEP-VASEERGRGIKLMRMLVDNVEVAR 225
Cdd:cd16936     1 VELAVSEAVTNAVRHAyrhdGPGPVRLELDLDPDRLRVEVTDSGPGFDPLRPADPdAGLREGGRGLALIRALMDEVGYRR 80

                          90
                  ....*....|...
gi 1469306857 226 RtdGAGTRVQMVK 238
Cdd:cd16936    81 T--PGGKTVWLEL 91
PRK04069 PRK04069
serine-protein kinase RsbW; Provisional
 146-238 5.82e-05

serine-protein kinase RsbW; Provisional


Pssm-ID: 235217 [Multi-domain]  Cd Length: 161  Bit Score: 42.22  E-value: 5.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857 146 DERYDVALASGEALGNAYDHA------GGIGcvLTVQAYGDRVVVEVLDRGAGYSIDET---------SEPVAS-EERGR 209
Cdd:PRK04069   38 DDIEDMKIAVSEACTNAVQHAykedevGEIH--IRFEIYEDRLEIVVADNGVSFDYETLksklgpydiSKPIEDlREGGL 115

                          90       100
                  ....*....|....*....|....*....
gi 1469306857 210 GIKLMRMLVDNVEVarRTDGaGTRVQMVK 238
Cdd:PRK04069  116 GLFLIETLMDDVTV--YKDS-GVTVSMTK 141
 
Name Accession Description Interval E-value
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
 5-95 8.28e-23

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 89.12  E-value: 8.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   5 NDIAVLTPPGDIDIATVPALRRRLDALIGRGVRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGEVVRFL 84
Cdd:cd07043     7 GGVLVVRLSGELDAATAPELREALEELLAEGPRRLVLDLSGVTFIDSSGLGVLLGAYKRARAAGGRLVLVNVSPAVRRVL 86

                          90
                  ....*....|.
gi 1469306857  85 EIARLVDILHV 95
Cdd:cd07043    87 ELTGLDRLFPI 97
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
117-238 1.49e-21

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 86.51  E-value: 1.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857 117 SVEVRQGIENLPYYRHRIAELLESLPLRRDERYDVALASGEALGNAYDHAGG---IGCV-LTVQAYGDRVVVEVLDRGAG 192
Cdd:COG2172     1 SLSLPADLEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGgdpDGPVeVELELDPDGLEIEVRDEGPG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1469306857 193 YSIDETSEPVASE-ERGRGIKLMRMLVDNVEVarRTDGAGTRVQMVK 238
Cdd:COG2172    81 FDPEDLPDPYSTLaEGGRGLFLIRRLMDEVEY--ESDPGGTTVRLVK 125
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 3-89 9.25e-20

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 81.05  E-value: 9.25e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   3 EWNDIAVLTPPGDIDIATVPALRRRLDALIGRGVRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGEVVR 82
Cdd:COG1366     6 VRDGVLVLPLIGELDAARAPELREALLEALETGARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPAVAR 85


                  ....*..
gi 1469306857  83 FLEIARL 89
Cdd:COG1366    86 VLELTGL 92
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
 1-96 6.06e-19

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 79.18  E-value: 6.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   1 MNEWNDIAVLTPPGDIDIATVPALRRRLDALI-GRGVRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGE 79
Cdd:TIGR00377   7 TEVQEGVVVVRLSGELDAHTAPLLREKVTPAAeRTGIRPIVLDLEDLEFMDSSGLGVLLGRYKQVRRVGGQLVLVSVSPR 86

                          90
                  ....*....|....*..
gi 1469306857  80 VVRFLEIARLVDILHVA 96
Cdd:TIGR00377  87 VARLLDITGLLRIIPIY 103
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 5-95 2.38e-16

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 72.26  E-value: 2.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   5 NDIAVLTPPGDIDIATVPALRRRLDALIGRG-VRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGEVVRF 83
Cdd:pfam01740   8 PGILILRLDGPLDFANAESLRERLLRALEEGeIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPSPEVART 87

                          90
                  ....*....|..
gi 1469306857  84 LEIARLVDILHV 95
Cdd:pfam01740  88 LEKTGLDDIIKI 99
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
131-238 5.29e-14

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 66.54  E-value: 5.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857 131 RHRIAELLESLPLRRDERYDVALASGEALGNAYDHAGGIG----CVLTVQAYGDRVVVEVLDRGAGYSIDETSEPVASE- 205
Cdd:pfam13581  12 RRVLEAVLRRAGLPEELLDEVELAVGEACTNAVEHAYREGpegpVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDLEEp 91

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1469306857 206 -----ERGRGIKLMRMLVDNVEVARrtDGAGTRVQMVK 238
Cdd:pfam13581  92 dedrkEGGRGLALIRGLMDDVEYTR--GGEGNTVRMRK 127
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 151-238 1.78e-13

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 64.21  E-value: 1.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857 151 VALASGEALGNAYDHA----GGIGCVLTVQAYGDRVVVEVLDRGAGYSIDETSEP-VASEERGRGIKLMRMLVDNVEVAR 225
Cdd:cd16936     1 VELAVSEAVTNAVRHAyrhdGPGPVRLELDLDPDRLRVEVTDSGPGFDPLRPADPdAGLREGGRGLALIRALMDEVGYRR 80

                          90
                  ....*....|...
gi 1469306857 226 RtdGAGTRVQMVK 238
Cdd:cd16936    81 T--PGGKTVWLEL 91
SpoIIAA COG5815
Stage II sporulation protein SpoIIAA (antagonist of anti-sigma F factor) [Cell cycle control, ...
 5-95 5.67e-13

Stage II sporulation protein SpoIIAA (antagonist of anti-sigma F factor) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444517  Cd Length: 110  Bit Score: 63.22  E-value: 5.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   5 NDIAVLTPPGDIDIATVPALRRRLDALI-GRGVRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGEVVRF 83
Cdd:COG5815     9 GDTLIVRLEGELDHHTAEELREKIDRAIeKGGVKHLILNLEGVSFMDSSGLGVILGRYKKIKALGGKVAVINVSPQVKRI 88

                          90
                  ....*....|..
gi 1469306857  84 LEIARLVDILHV 95
Cdd:COG5815    89 FELSGLFKIIKI 100
MlaB COG3113
Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, ...
 5-93 2.75e-12

Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, contains STAS domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442347 [Multi-domain]  Cd Length: 97  Bit Score: 61.03  E-value: 2.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   5 NDIAVLTPPGDIDIATVPALRRRLDALIGRGvRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGEVVRFL 84
Cdd:COG3113     9 AEGGTLRLSGELTRDTVLALWAQLLALLAAG-GAVEIDLSGVTRVDSAGLALLLELLREARAQGKTLRLTGVPEQLRTLA 87


                  ....*....
gi 1469306857  85 EIARLVDIL 93
Cdd:COG3113    88 ALYGLDELL 96
STAS_2 pfam13466
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 13-89 9.27e-10

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 433231 [Multi-domain]  Cd Length: 80  Bit Score: 53.77  E-value: 9.27e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1469306857  13 PGDIDIATVPALRRRLDALIGRGvRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGEVVRFLEIARL 89
Cdd:pfam13466   4 SGELDADTAPALREALLAALAAG-SPVVVDLSGVERVDSAGLALLLALARRARARGKRLVLRGLPPALLRLLRLLGL 79
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
 2-95 1.75e-09

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 53.78  E-value: 1.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   2 NEWNDIAVLTPPGDIDIATVPALRRRLDALIGRG--VRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGE 79
Cdd:cd07042     5 EEPPGVLIYRIDGPLFFGNAEYFKDRLLRLVDEDppLKVVILDLSAVNFIDSTAAEALEELVKDLRKRGVELYLAGLNPQ 84

                          90
                  ....*....|....*.
gi 1469306857  80 VVRFLEIARLVDILHV 95
Cdd:cd07042    85 VRELLERAGLLDEIGE 100
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
 6-93 1.23e-07

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 52.03  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   6 DIAVLTPPGDIDIATVPALRRRLDAlIGRGVRRVVINCQAVSFIDSTGLAFLLTRARELMRREGLLSLVNASGEVVRFLE 85
Cdd:COG0659   422 GVLVYRLDGPLFFGNAERLKERLDA-LAPDPRVVILDLSAVPFIDATALEALEELAERLRARGITLELAGLKPPVRDLLE 500


                  ....*...
gi 1469306857  86 IARLVDIL 93
Cdd:COG0659   501 RAGLLDEL 508
PRK04069 PRK04069
serine-protein kinase RsbW; Provisional
 146-238 5.82e-05

serine-protein kinase RsbW; Provisional


Pssm-ID: 235217 [Multi-domain]  Cd Length: 161  Bit Score: 42.22  E-value: 5.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857 146 DERYDVALASGEALGNAYDHA------GGIGcvLTVQAYGDRVVVEVLDRGAGYSIDET---------SEPVAS-EERGR 209
Cdd:PRK04069   38 DDIEDMKIAVSEACTNAVQHAykedevGEIH--IRFEIYEDRLEIVVADNGVSFDYETLksklgpydiSKPIEDlREGGL 115

                          90       100
                  ....*....|....*....|....*....
gi 1469306857 210 GIKLMRMLVDNVEVarRTDGaGTRVQMVK 238
Cdd:PRK04069  116 GLFLIETLMDDVTV--YKDS-GVTVSMTK 141
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 157-234 9.73e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 40.23  E-value: 9.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857 157 EALGNAYDHAGGIGCVLTVQAYGDRVVVEVLDRGAGYsidetSEPVASEERGRGIKLMR---MLVDNVEVARRTDGAGTR 233
Cdd:cd16917     7 EALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGF-----DGPAPPGGGGFGLLGMReraELLGGTLTIGSRPGGGTR 81


                  .
gi 1469306857 234 V 234
Cdd:cd16917    82 V 82
STAS cd06844
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of ...
 6-64 2.31e-04

Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain is found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors, like anti-anti-sigma factors and "stressosome" components. The sigma factor regulators are involved in protein-protein interaction which is regulated by phosphorylation.


Pssm-ID: 132911 [Multi-domain]  Cd Length: 100  Bit Score: 39.39  E-value: 2.31e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857   6 DIAVLTPPGDIDIATVPALRRRL-DALIGRGVRRVVINCQAVSFIDSTGLAFLLTRAREL 64
Cdd:cd06844     8 DYWVVRLEGELDHHSVEQFKEELlHNITNVAGKTIVIDISALEFMDSSGTGVLLERSRLA 67
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 157-236 6.28e-04

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 38.50  E-value: 6.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1469306857 157 EALGNAYDHAGGIGCV-LTVQAyGDRVVVEVLDRGAGYSIDE---------TSEPVASEERGRGIKLMRMLVDNVEV--- 223
Cdd:pfam02518  12 NLLDNALKHAAKAGEItVTLSE-GGELTLTVEDNGIGIPPEDlprifepfsTADKRGGGGTGLGLSIVRKLVELLGGtit 90

                          90
                  ....*....|...
gi 1469306857 224 ARRTDGAGTRVQM 236
Cdd:pfam02518  91 VESEPGGGTTVTL 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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