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Conserved domains on  [gi|1473345379|ref|WP_117812302|]
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MOSC domain-containing protein [Faecalibacillus faecis]

Protein Classification

MOSC domain-containing protein( domain architecture ID 13496049)

MOSC domain-containing protein is a MogA/MoaB/MoaC family molybdenum cofactor biosynthesis protein such as MPT-adenylyltransferase (MogA), which converts MPT to adenylylated MPT (MPT-AMP), or it may catalyze the formation of the cyclic pyranopterin monophosphate intermediate(MoaC)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoaB COG0521
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin ...
 144-308 3.61e-75

Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin biosynthesis enzyme MoaB/MogA is part of the Pathway/BioSystem: Molybdopterin biosynthesis


:

Pssm-ID: 440287 [Multi-domain]  Cd Length: 169  Bit Score: 227.69  E-value: 3.61e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 144 KEKDKRLRVAILTLSDKGSQGLREDLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRCHNDLIITTGGTGLS 223
Cdd:COG0521     4 ARAFVPLRIAVLTVSDRRSRGEREDTSGPALVELLEEAGHEVVARRIVPDDKDAIRAALRELIDDEGVDLVLTTGGTGLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 224 MRDVTPEATLKVATRNVPGISEAIRYESMKY-TNRAMLSRGVSILRNQTLIINLPGSLKAVKESLDIIIDPLKHGLEILK 302
Cdd:COG0521    84 PRDVTPEATRPLLDKELPGFGELFRALSLEEiGPSAILSRAVAGIRGGTLIFNLPGSPGAVREALEAILPELPHAVDLLN 163


                  ....*.
gi 1473345379 303 GEAHDC 308
Cdd:COG0521   164 GVDHEC 169
YiiM COG2258
N-hydroxylaminopurine reductase YiiM, contains MOSC domain [Nucleotide transport and ...
 2-153 2.85e-51

N-hydroxylaminopurine reductase YiiM, contains MOSC domain [Nucleotide transport and metabolism, Defense mechanisms];


:

Pssm-ID: 441859  Cd Length: 162  Bit Score: 166.50  E-value: 2.85e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379   2 AGKVKAICLSKKKGTAKIPVEKIEVIENYGFKNDAHA-----GSWHRQVSLLSYETREAFK-QMGSTVEDGSFGENLLIS 75
Cdd:COG2258     1 MGKVLAVNIGKESGIPKRPVEGAVLVAGLGLEGDAQAdrkhhGGPDRAVTLYAAEHYDAWAaELGRDLPPGAFGENLTTE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379  76 GIDFNAIEVGTCLKIGDVILEITQLGKSCHNHCAIYHQVG----KCIMPTNGLFSRVLKGGTIQLNDSVEVLKEKDKRLR 151
Cdd:COG2258    81 GLDLSDLPIGDRLRIGEALLEVTQPRKPCHKLEARLGGPGlakaMCQMGRGGIYARVLEGGEVRAGDEVELLERPEPGVT 160


                  ..
gi 1473345379 152 VA 153
Cdd:COG2258   161 VA 162
 
Name Accession Description Interval E-value
MoaB COG0521
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin ...
 144-308 3.61e-75

Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin biosynthesis enzyme MoaB/MogA is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440287 [Multi-domain]  Cd Length: 169  Bit Score: 227.69  E-value: 3.61e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 144 KEKDKRLRVAILTLSDKGSQGLREDLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRCHNDLIITTGGTGLS 223
Cdd:COG0521     4 ARAFVPLRIAVLTVSDRRSRGEREDTSGPALVELLEEAGHEVVARRIVPDDKDAIRAALRELIDDEGVDLVLTTGGTGLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 224 MRDVTPEATLKVATRNVPGISEAIRYESMKY-TNRAMLSRGVSILRNQTLIINLPGSLKAVKESLDIIIDPLKHGLEILK 302
Cdd:COG0521    84 PRDVTPEATRPLLDKELPGFGELFRALSLEEiGPSAILSRAVAGIRGGTLIFNLPGSPGAVREALEAILPELPHAVDLLN 163


                  ....*.
gi 1473345379 303 GEAHDC 308
Cdd:COG0521   164 GVDHEC 169
MogA_MoaB cd00886
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum ...
 150-301 3.81e-70

MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.


Pssm-ID: 238451 [Multi-domain]  Cd Length: 152  Bit Score: 214.65  E-value: 3.81e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 150 LRVAILTLSDKGSQGLREDLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRCHNDLIITTGGTGLSMRDVTP 229
Cdd:cd00886     1 LRAAVLTVSDTRSAGEAEDRSGPALVELLEEAGHEVVAYEIVPDDKDEIREALIEWADEDGVDLILTTGGTGLAPRDVTP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1473345379 230 EATLKVATRNVPGISEAIRYESMKYTNRAMLSRGVSILRNQTLIINLPGSLKAVKESLDIIIDPLKHGLEIL 301
Cdd:cd00886    81 EATRPLLDKELPGFGEAFRALSLEETGTAMLSRAVAGIRGGTLIFNLPGSPKAVREALEVILPELPHLLDLL 152
mogA PRK09417
molybdenum cofactor biosynthesis protein MogA; Provisional
 150-292 6.65e-54

molybdenum cofactor biosynthesis protein MogA; Provisional


Pssm-ID: 181837 [Multi-domain]  Cd Length: 193  Bit Score: 174.37  E-value: 6.65e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 150 LRVAILTLSDKGSQGLREDLSGSYIQDYFKErgyYVTS-----YEILPDEQALIEQALINLSDRCHNDLIITTGGTGLSM 224
Cdd:PRK09417    4 LKIGLVSISDRASSGVYEDKGIPALEEWLAS---ALTSpfeieTRLIPDEQDLIEQTLIELVDEMGCDLVLTTGGTGPAR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1473345379 225 RDVTPEATLKVATRNVPGISEAIRYESMKYTNRAMLSRGVSILRNQTLIINLPGSLKAVKESLDIIID 292
Cdd:PRK09417   81 RDVTPEATLAVADKEMPGFGEQMRQISLKFVPTAILSRQVAVIRGQSLIINLPGQPKSIKETLEGLKD 148
YiiM COG2258
N-hydroxylaminopurine reductase YiiM, contains MOSC domain [Nucleotide transport and ...
 2-153 2.85e-51

N-hydroxylaminopurine reductase YiiM, contains MOSC domain [Nucleotide transport and metabolism, Defense mechanisms];


Pssm-ID: 441859  Cd Length: 162  Bit Score: 166.50  E-value: 2.85e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379   2 AGKVKAICLSKKKGTAKIPVEKIEVIENYGFKNDAHA-----GSWHRQVSLLSYETREAFK-QMGSTVEDGSFGENLLIS 75
Cdd:COG2258     1 MGKVLAVNIGKESGIPKRPVEGAVLVAGLGLEGDAQAdrkhhGGPDRAVTLYAAEHYDAWAaELGRDLPPGAFGENLTTE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379  76 GIDFNAIEVGTCLKIGDVILEITQLGKSCHNHCAIYHQVG----KCIMPTNGLFSRVLKGGTIQLNDSVEVLKEKDKRLR 151
Cdd:COG2258    81 GLDLSDLPIGDRLRIGEALLEVTQPRKPCHKLEARLGGPGlakaMCQMGRGGIYARVLEGGEVRAGDEVELLERPEPGVT 160


                  ..
gi 1473345379 152 VA 153
Cdd:COG2258   161 VA 162
PRK14499 PRK14499
cyclic pyranopterin monophosphate synthase MoaC/MOSC-domain-containing protein;
4-145 5.95e-48

cyclic pyranopterin monophosphate synthase MoaC/MOSC-domain-containing protein;


Pssm-ID: 237733 [Multi-domain]  Cd Length: 308  Bit Score: 162.72  E-value: 5.95e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379   4 KVKAICLSKKKGTAKIPVEKIEVIENYGFKNDAHAGSWHRQVSLLSYETREAFKQMG-STVEDGSFGENLLISGIDFNAI 82
Cdd:PRK14499  164 KVVSINISRQKGTPKEPVEEAVLIENHGIEGDAHAGTWHRQVSLLDISSIKKMEEYGlKGLCFGKFAENITTENLDLQKI 243

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1473345379  83 EVGTCLKIGD-VILEITQLGKSCHNH-CAIYHQVGKCIMPTNGLFSRVLKGGTIQLNDSVEVLKE 145
Cdd:PRK14499  244 SLGTKLKIGDnVVLEISQIGKKCHGSgCEIARQVGVCIMPKEGLFAKVLKGGKIKPGDIIEILNN 308
MoCF_biosynth pfam00994
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ...
 153-296 1.81e-35

Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.


Pssm-ID: 425979 [Multi-domain]  Cd Length: 143  Bit Score: 125.05  E-value: 1.81e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 153 AILTLSDKGSQGLREDLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRChnDLIITTGGTGLSMRDVTPEAT 232
Cdd:pfam00994   1 AIITTGDELLPGQIRDTNGPLLAALLREAGAEVIRYGIVPDDPEAIKEALRAAAEEA--DVVITTGGTGPGPDDVTPEAL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1473345379 233 LKVATRNVPGISEAIRYESMKYTNRAMLSRGVSILRNQTLIINLPGSLKAVKESLDIIIDP-LKH 296
Cdd:pfam00994  79 AELGGRELPGFEELFRGVSLKPGKPVGTAPGAILSRAGKTVFGLPGSPVAAKVMFELLLLPlLRH 143
molyb_syn TIGR00177
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ...
 150-293 3.35e-32

molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.


Pssm-ID: 272944 [Multi-domain]  Cd Length: 148  Bit Score: 117.03  E-value: 3.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 150 LRVAILTLSD---KGSQGLRE----DLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRChnDLIITTGGTGL 222
Cdd:TIGR00177   1 PRVAVISVGDelvEGGQPLEPgqiyDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEA--DVVLTTGGTGV 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1473345379 223 SMRDVTPEATLKVATRNVPGISEAIRYESMkytnrAMLSRGVSIL----RNQTLIINLPGSLKAVKESLDIIIDP 293
Cdd:TIGR00177  79 GPRDVTPEALEELGEKEIPGFGEFRMLSSL-----PVLSRPGKPAtagvRGGTLIFNLPGNPVSALVTFEVLILP 148
MoCF_biosynth smart00852
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ...
 153-290 1.42e-31

Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.


Pssm-ID: 214856 [Multi-domain]  Cd Length: 138  Bit Score: 114.99  E-value: 1.42e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379  153 AILTLSDKGSQGLR-EDLSGSYIQDYFKERGYYVTSYEIL--PDEQALIEQALINLSDRChnDLIITTGGTGLSMRDVTP 229
Cdd:smart00852   1 AIISTGDELLSGGQiRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEA--DVVITTGGTGPGPDDLTP 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1473345379  230 EATLKVATRNVPGISEAIRYESMKyTNRAMLSRGVSILRNQTLIINLPGSLKAVKESLDII 290
Cdd:smart00852  79 EALAELGGRELLGHGVAMRPGGPP-GPLANLSGTAPGVRGKKPVFGLPGNPVAALVMFEEL 138
MOSC pfam03473
MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich ...
 34-141 1.27e-08

MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as Swiss:P32157, or fused to other domains such as NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters.


Pssm-ID: 460936  Cd Length: 116  Bit Score: 52.20  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379  34 NDAHAGSWHRQVSLLSYETREAFKQM--GSTVEDGSFGENLLISGIDFNAIEVGTCLKIGDVIL--EITQLGKSCH--NH 107
Cdd:pfam03473   1 DRKHHGGDDKAVLLYSRESYDAWNAElgRGPLDPGRFRENLVVSGGTWKEVCIGDRFRIGGACLrlEVTQPREPCKtlAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1473345379 108 CAIYHQVGKcIMPTNGLF---SRVLKGGTIQLNDSVE 141
Cdd:pfam03473  81 RFGERRVDK-RFKGSGRFgwyLRVLEEGTVRVGDEVE 116
 
Name Accession Description Interval E-value
MoaB COG0521
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin ...
 144-308 3.61e-75

Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin biosynthesis enzyme MoaB/MogA is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440287 [Multi-domain]  Cd Length: 169  Bit Score: 227.69  E-value: 3.61e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 144 KEKDKRLRVAILTLSDKGSQGLREDLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRCHNDLIITTGGTGLS 223
Cdd:COG0521     4 ARAFVPLRIAVLTVSDRRSRGEREDTSGPALVELLEEAGHEVVARRIVPDDKDAIRAALRELIDDEGVDLVLTTGGTGLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 224 MRDVTPEATLKVATRNVPGISEAIRYESMKY-TNRAMLSRGVSILRNQTLIINLPGSLKAVKESLDIIIDPLKHGLEILK 302
Cdd:COG0521    84 PRDVTPEATRPLLDKELPGFGELFRALSLEEiGPSAILSRAVAGIRGGTLIFNLPGSPGAVREALEAILPELPHAVDLLN 163


                  ....*.
gi 1473345379 303 GEAHDC 308
Cdd:COG0521   164 GVDHEC 169
MogA_MoaB cd00886
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum ...
 150-301 3.81e-70

MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.


Pssm-ID: 238451 [Multi-domain]  Cd Length: 152  Bit Score: 214.65  E-value: 3.81e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 150 LRVAILTLSDKGSQGLREDLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRCHNDLIITTGGTGLSMRDVTP 229
Cdd:cd00886     1 LRAAVLTVSDTRSAGEAEDRSGPALVELLEEAGHEVVAYEIVPDDKDEIREALIEWADEDGVDLILTTGGTGLAPRDVTP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1473345379 230 EATLKVATRNVPGISEAIRYESMKYTNRAMLSRGVSILRNQTLIINLPGSLKAVKESLDIIIDPLKHGLEIL 301
Cdd:cd00886    81 EATRPLLDKELPGFGEAFRALSLEETGTAMLSRAVAGIRGGTLIFNLPGSPKAVREALEVILPELPHLLDLL 152
mogA PRK09417
molybdenum cofactor biosynthesis protein MogA; Provisional
 150-292 6.65e-54

molybdenum cofactor biosynthesis protein MogA; Provisional


Pssm-ID: 181837 [Multi-domain]  Cd Length: 193  Bit Score: 174.37  E-value: 6.65e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 150 LRVAILTLSDKGSQGLREDLSGSYIQDYFKErgyYVTS-----YEILPDEQALIEQALINLSDRCHNDLIITTGGTGLSM 224
Cdd:PRK09417    4 LKIGLVSISDRASSGVYEDKGIPALEEWLAS---ALTSpfeieTRLIPDEQDLIEQTLIELVDEMGCDLVLTTGGTGPAR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1473345379 225 RDVTPEATLKVATRNVPGISEAIRYESMKYTNRAMLSRGVSILRNQTLIINLPGSLKAVKESLDIIID 292
Cdd:PRK09417   81 RDVTPEATLAVADKEMPGFGEQMRQISLKFVPTAILSRQVAVIRGQSLIINLPGQPKSIKETLEGLKD 148
YiiM COG2258
N-hydroxylaminopurine reductase YiiM, contains MOSC domain [Nucleotide transport and ...
 2-153 2.85e-51

N-hydroxylaminopurine reductase YiiM, contains MOSC domain [Nucleotide transport and metabolism, Defense mechanisms];


Pssm-ID: 441859  Cd Length: 162  Bit Score: 166.50  E-value: 2.85e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379   2 AGKVKAICLSKKKGTAKIPVEKIEVIENYGFKNDAHA-----GSWHRQVSLLSYETREAFK-QMGSTVEDGSFGENLLIS 75
Cdd:COG2258     1 MGKVLAVNIGKESGIPKRPVEGAVLVAGLGLEGDAQAdrkhhGGPDRAVTLYAAEHYDAWAaELGRDLPPGAFGENLTTE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379  76 GIDFNAIEVGTCLKIGDVILEITQLGKSCHNHCAIYHQVG----KCIMPTNGLFSRVLKGGTIQLNDSVEVLKEKDKRLR 151
Cdd:COG2258    81 GLDLSDLPIGDRLRIGEALLEVTQPRKPCHKLEARLGGPGlakaMCQMGRGGIYARVLEGGEVRAGDEVELLERPEPGVT 160


                  ..
gi 1473345379 152 VA 153
Cdd:COG2258   161 VA 162
PRK14499 PRK14499
cyclic pyranopterin monophosphate synthase MoaC/MOSC-domain-containing protein;
4-145 5.95e-48

cyclic pyranopterin monophosphate synthase MoaC/MOSC-domain-containing protein;


Pssm-ID: 237733 [Multi-domain]  Cd Length: 308  Bit Score: 162.72  E-value: 5.95e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379   4 KVKAICLSKKKGTAKIPVEKIEVIENYGFKNDAHAGSWHRQVSLLSYETREAFKQMG-STVEDGSFGENLLISGIDFNAI 82
Cdd:PRK14499  164 KVVSINISRQKGTPKEPVEEAVLIENHGIEGDAHAGTWHRQVSLLDISSIKKMEEYGlKGLCFGKFAENITTENLDLQKI 243

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1473345379  83 EVGTCLKIGD-VILEITQLGKSCHNH-CAIYHQVGKCIMPTNGLFSRVLKGGTIQLNDSVEVLKE 145
Cdd:PRK14499  244 SLGTKLKIGDnVVLEISQIGKKCHGSgCEIARQVGVCIMPKEGLFAKVLKGGKIKPGDIIEILNN 308
moaC PRK03604
bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional
 149-307 4.77e-47

bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional


Pssm-ID: 235138 [Multi-domain]  Cd Length: 312  Bit Score: 160.49  E-value: 4.77e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 149 RLRVAILTLSDKGSQGLREDLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRCHnDLIITTGGTGLSMRDVT 228
Cdd:PRK03604  155 RTSAAVLVLSDSIAAGTKEDRSGKLIVEGLEEAGFEVSHYTIIPDEPAEIAAAVAAWIAEGY-ALIITTGGTGLGPRDVT 233

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1473345379 229 PEATLKVATRNVPGISEAIRYESMKYTNRAMLSRGVSILRNQTLIINLPGSLKAVKESLDIIIDPLKHGLEILKGEAHD 307
Cdd:PRK03604  234 PEALAPLLERRLPGIAEALRSWGQGRTPTAMLSRLVAGMIGNSLVVALPGSPGGASDALAVLLPALFHAFAMVKGEGHH 312
MoCF_biosynth pfam00994
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ...
 153-296 1.81e-35

Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.


Pssm-ID: 425979 [Multi-domain]  Cd Length: 143  Bit Score: 125.05  E-value: 1.81e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 153 AILTLSDKGSQGLREDLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRChnDLIITTGGTGLSMRDVTPEAT 232
Cdd:pfam00994   1 AIITTGDELLPGQIRDTNGPLLAALLREAGAEVIRYGIVPDDPEAIKEALRAAAEEA--DVVITTGGTGPGPDDVTPEAL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1473345379 233 LKVATRNVPGISEAIRYESMKYTNRAMLSRGVSILRNQTLIINLPGSLKAVKESLDIIIDP-LKH 296
Cdd:pfam00994  79 AELGGRELPGFEELFRGVSLKPGKPVGTAPGAILSRAGKTVFGLPGSPVAAKVMFELLLLPlLRH 143
PLN02699 PLN02699
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
 147-304 3.52e-35

Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase


Pssm-ID: 215376 [Multi-domain]  Cd Length: 659  Bit Score: 134.55  E-value: 3.52e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 147 DKRLRVAILTLSDKGSQGLREDLSGSY---IQDYFKER--GYYVTSYEILPDEQALIEQALINLSDRCHNDLIITTGGTG 221
Cdd:PLN02699  456 NPEVKVAILTVSDTVSSGAGPDRSGPRavsVVNSSSEKlgGAKVVATAVVPDDVEKIKDVLQKWSDIDRMDLILTLGGTG 535

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 222 LSMRDVTPEATLKVATRNVPGISEAIRYESMKYTNRAMLSRGVSILRNQTLIINLPGSLKAVKESLDIIIDPLKHGLEIL 301
Cdd:PLN02699  536 FTPRDVTPEATKEVIQKETPGLLYVMMQESLKVTPFAMLSRSAAGIRGSTLIINMPGNPNAVAECMEALLPALKHALKQI 615


                  ...
gi 1473345379 302 KGE 304
Cdd:PLN02699  616 KGD 618
MoCF_BD cd00758
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ...
 151-294 3.92e-33

MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.


Pssm-ID: 238387 [Multi-domain]  Cd Length: 133  Bit Score: 118.60  E-value: 3.92e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 151 RVAILTLSDKGSQGLREDLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRChnDLIITTGGTGLSMRDVTPE 230
Cdd:cd00758     1 RVAIVTVSDELSQGQIEDTNGPALEALLEDLGCEVIYAGVVPDDADSIRAALIEASREA--DLVLTTGGTGVGRRDVTPE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1473345379 231 ATLKVATRNVPGISEAIryesmkytnrAMLSRGVSILRNQTLIINLPGSLKAVKESLDIIIDPL 294
Cdd:cd00758    79 ALAELGEREAHGKGVAL----------APGSRTAFGIIGKVLIINLPGSPKSALTTFEALVLPA 132
molyb_syn TIGR00177
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ...
 150-293 3.35e-32

molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.


Pssm-ID: 272944 [Multi-domain]  Cd Length: 148  Bit Score: 117.03  E-value: 3.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 150 LRVAILTLSD---KGSQGLRE----DLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRChnDLIITTGGTGL 222
Cdd:TIGR00177   1 PRVAVISVGDelvEGGQPLEPgqiyDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEA--DVVLTTGGTGV 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1473345379 223 SMRDVTPEATLKVATRNVPGISEAIRYESMkytnrAMLSRGVSIL----RNQTLIINLPGSLKAVKESLDIIIDP 293
Cdd:TIGR00177  79 GPRDVTPEALEELGEKEIPGFGEFRMLSSL-----PVLSRPGKPAtagvRGGTLIFNLPGNPVSALVTFEVLILP 148
MoCF_biosynth smart00852
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ...
 153-290 1.42e-31

Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.


Pssm-ID: 214856 [Multi-domain]  Cd Length: 138  Bit Score: 114.99  E-value: 1.42e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379  153 AILTLSDKGSQGLR-EDLSGSYIQDYFKERGYYVTSYEIL--PDEQALIEQALINLSDRChnDLIITTGGTGLSMRDVTP 229
Cdd:smart00852   1 AIISTGDELLSGGQiRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEA--DVVITTGGTGPGPDDLTP 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1473345379  230 EATLKVATRNVPGISEAIRYESMKyTNRAMLSRGVSILRNQTLIINLPGSLKAVKESLDII 290
Cdd:smart00852  79 EALAELGGRELLGHGVAMRPGGPP-GPLANLSGTAPGVRGKKPVFGLPGNPVAALVMFEEL 138
MOSC pfam03473
MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich ...
 34-141 1.27e-08

MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as Swiss:P32157, or fused to other domains such as NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters.


Pssm-ID: 460936  Cd Length: 116  Bit Score: 52.20  E-value: 1.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379  34 NDAHAGSWHRQVSLLSYETREAFKQM--GSTVEDGSFGENLLISGIDFNAIEVGTCLKIGDVIL--EITQLGKSCH--NH 107
Cdd:pfam03473   1 DRKHHGGDDKAVLLYSRESYDAWNAElgRGPLDPGRFRENLVVSGGTWKEVCIGDRFRIGGACLrlEVTQPREPCKtlAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1473345379 108 CAIYHQVGKcIMPTNGLF---SRVLKGGTIQLNDSVE 141
Cdd:pfam03473  81 RFGERRVDK-RFKGSGRFgwyLRVLEEGTVRVGDEVE 116
MoeA cd00887
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 148-231 4.05e-07

MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.


Pssm-ID: 238452 [Multi-domain]  Cd Length: 394  Bit Score: 50.96  E-value: 4.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 148 KRLRVAILT----LSDKGSQgLRE----DLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRChnDLIITTGG 219
Cdd:cd00887   167 RRPRVAIIStgdeLVEPGEP-LAPgqiyDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEEA--DVVITSGG 243

                          90
                  ....*....|....
gi 1473345379 220 TglSM--RDVTPEA 231
Cdd:cd00887   244 V--SVgdYDFVKEV 255
MoeA COG0303
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ...
 138-231 6.82e-07

Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440072 [Multi-domain]  Cd Length: 401  Bit Score: 50.09  E-value: 6.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 138 DSVEVLKekdkRLRVAILT----LSDKGsqglrEDL-------SGSY-IQDYFKERGYYVTSYEILPDEQALIEQALINL 205
Cdd:COG0303   165 AEVPVYR----RPRVAILStgdeLVEPG-----EPLgpgqiydSNSYmLAALLREAGAEVVDLGIVPDDPEALRAALREA 235

                          90       100
                  ....*....|....*....|....*.
gi 1473345379 206 SDRChnDLIITTGGTGLSMRDVTPEA 231
Cdd:COG0303   236 LAEA--DLVITSGGVSVGDYDLVKEA 259
cinA cd00885
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon ...
 164-231 4.03e-05

Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, where the domain is presumed to bind molybdopterin.


Pssm-ID: 238450 [Multi-domain]  Cd Length: 170  Bit Score: 43.24  E-value: 4.03e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1473345379 164 GLREDLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRChnDLIITTGGTGLSMRDVTPEA 231
Cdd:cd00885    14 GQIVDTNAAFLAKELAELGIEVYRVTVVGDDEDRIAEALRRASERA--DLVITTGGLGPTHDDLTREA 79
MoeA_like cd03522
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in ...
 148-231 9.34e-05

MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is unknown.


Pssm-ID: 239599  Cd Length: 312  Bit Score: 43.30  E-value: 9.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 148 KRLRVAILTLSDKGSQGLREDLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRChNDLIITTGGTGLSMRDV 227
Cdd:cd03522   158 RPLRVGLIVTGSEVYGGRIEDKFGPVLRARLAALGVELVEQVIVPHDEAAIAAAIAEALEAG-AELLILTGGASVDPDDV 236


                  ....
gi 1473345379 228 TPEA 231
Cdd:cd03522   237 TPAA 240
PRK14497 PRK14497
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional
 173-226 1.92e-03

putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional


Pssm-ID: 172968 [Multi-domain]  Cd Length: 546  Bit Score: 39.79  E-value: 1.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1473345379 173 YIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRChnDLIITTGGTGLSMRD 226
Cdd:PRK14497  210 YLYSKLKSEGYKIVGLSLLSDDKESIKNEIKRAISVA--DVLILTGGTSAGEKD 261
PRK14498 PRK14498
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ...
 138-228 2.26e-03

putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional


Pssm-ID: 237732 [Multi-domain]  Cd Length: 633  Bit Score: 39.43  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1473345379 138 DSVEVLKekdkRLRVAILT----LSDKGSQgLRE----DLSGSYIQDYFKERGYYVTSYEILPDEQALIEQALINLSDRC 209
Cdd:PRK14498  179 AEVPVYK----KPRVGIIStgdeLVEPGEP-LKPgkiyDVNSYTLAAAVEEAGGEPVRYGIVPDDEEELEAALRKALKEC 253

                          90
                  ....*....|....*....
gi 1473345379 210 hnDLIITTGGTGLSMRDVT 228
Cdd:PRK14498  254 --DLVLLSGGTSAGAGDVT 270
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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