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bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE [Salinibacter ruber]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10011316)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0032259|GO:1904047
PubMed:  9045837|12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 15-242 5.27e-97

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


:

Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 283.20  E-value: 5.27e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  15 KAEAVESMFDAVAPRYDLLNRVLSAGIDRYWRSRAVRTLRAEQPRRVLDVATGTADLALKAQRTLHPR-ETIGIDLSAKM 93
Cdd:PRK00216    9 KQEKVAEMFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKTgEVVGLDFSEGM 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  94 LDRGREKIEQAGLAARIALQRADAADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVVLEFSTPRTTPIK 173
Cdd:PRK00216   89 LAVGREKLRDLGLSGNVEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGRLVILEFSKPTNPPLK 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1475473643 174 QLYAWYSRHVLPRIGGLLSPDQGAYEYLPSSVAAFPDGVDFLRRMEGAGFVDLTWTPLTFGIASLYTGR 242
Cdd:PRK00216  169 KAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRYRNLTGGIVALHVGY 237
 
Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 15-242 5.27e-97

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 283.20  E-value: 5.27e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  15 KAEAVESMFDAVAPRYDLLNRVLSAGIDRYWRSRAVRTLRAEQPRRVLDVATGTADLALKAQRTLHPR-ETIGIDLSAKM 93
Cdd:PRK00216    9 KQEKVAEMFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKTgEVVGLDFSEGM 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  94 LDRGREKIEQAGLAARIALQRADAADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVVLEFSTPRTTPIK 173
Cdd:PRK00216   89 LAVGREKLRDLGLSGNVEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGRLVILEFSKPTNPPLK 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1475473643 174 QLYAWYSRHVLPRIGGLLSPDQGAYEYLPSSVAAFPDGVDFLRRMEGAGFVDLTWTPLTFGIASLYTGR 242
Cdd:PRK00216  169 KAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRYRNLTGGIVALHVGY 237
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 19-241 6.16e-90

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 264.89  E-value: 6.16e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  19 VESMFDAVAPRYDLLNRVLSAGIDRYWRSRAVRTLRAEQPRRVLDVATGTADLALK-AQRTLHPRETIGIDLSAKMLDRG 97
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLNDLLSFGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIElAKSAPDRGKVTGVDFSSEMLEVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  98 REKieqAGLAARIALQRADAADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVVLEFSTPRTTPIKQLYA 177
Cdd:TIGR01934  81 KKK---SELPLNIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEFSKPANALLKKFYK 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1475473643 178 WYSRHVLPRIGGLLSPDQGAYEYLPSSVAAFPDGVDFLRRMEGAGFVDLTWTPLTFGIASLYTG 241
Cdd:TIGR01934 158 FYLKNVLPSIGGLISKNAEAYTYLPESIRAFPSQEELAAMLKEAGFEEVRYRSLTFGVAAIHVG 221
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
17-241 1.02e-61

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 193.04  E-value: 1.02e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  17 EAVESMFDAVAPRYDLLNRVLSAGIDRYWRSRAVRTLRAEQPRRVLDVATGTADLALKAQRTLHPR-ETIGIDLSAKMLD 95
Cdd:pfam01209   2 QRVGDVFSSVASKYDLMNDVISFGIHRLWKDFTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSAGSSgKVVGLDINENMLK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  96 RGREKIEQAGLAaRIALQRADAADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVVLEFSTPRTTPIKQL 175
Cdd:pfam01209  82 EGEKKAKEEGKY-NIEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVVCLEFSKPENPLLSQA 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1475473643 176 YAWYSRHVLPRIGGLLSPDQGAYEYLPSSVAAFPDGVDFLRRMEGAGFVDLTWTPLTFGIASLYTG 241
Cdd:pfam01209 161 YELYFKYVMPFMGKMFAKSYKSYQYLQESIRDFPDQKTLASMFEKAGFKSVGYESLTGGIAAIHWG 226
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 23-175 1.22e-34

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 120.87  E-value: 1.22e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  23 FDAVAPRYDLLNRVLSAgidrywrsravrtLRAEQPRRVLDVATGTADLALKAQRtlHPRETIGIDLSAKMLDRGREKIE 102
Cdd:COG2226     1 FDRVAARYDGREALLAA-------------LGLRPGARVLDLGCGTGRLALALAE--RGARVTGVDISPEMLELARERAA 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1475473643 103 QAGLaaRIALQRADAADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVVLEFSTPRTTPIKQL 175
Cdd:COG2226    66 EAGL--NVEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEEL 136
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 60-161 4.44e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.21  E-value: 4.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  60 RVLDVATGTADLALKAQRtLHPRETIGIDLSAKMLDRGReKIEQAGLAARIALQRADAADLPFD-DGAFDAAFVAFGVR- 137
Cdd:cd02440     1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVALELAR-KAAAALLADNVEVLKGDAEELPPEaDESFDVIISDPPLHh 78

                          90       100
                  ....*....|....*....|....
gi 1475473643 138 NFEDLDAGLGDIRRVLRPGGALVV 161
Cdd:cd02440    79 LVEDLARFLEEARRLLKPGGVLVL 102
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
59-172 2.10e-06

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 47.03  E-value: 2.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643   59 RRVLDVATGTA-DLALKAQRTLHpRETIGIDLSAKMLDRGREKIEQAGLAARIALQRADAADLPFDDgAFDAAF---VAF 134
Cdd:smart00828   1 KRVLDFGCGYGsDLIDLAERHPH-LQLHGYTISPEQAEVGRERIRALGLQGRIRIFYRDSAKDPFPD-TYDLVFgfeVIH 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1475473643  135 GVRNFEDLdagLGDIRRVLRPGGALVVLEFSTPRTTPI 172
Cdd:smart00828  79 HIKDKMDL---FSNISRHLKDGGHLVLADFIANLLSAI 113
 
Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 15-242 5.27e-97

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 283.20  E-value: 5.27e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  15 KAEAVESMFDAVAPRYDLLNRVLSAGIDRYWRSRAVRTLRAEQPRRVLDVATGTADLALKAQRTLHPR-ETIGIDLSAKM 93
Cdd:PRK00216    9 KQEKVAEMFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKTgEVVGLDFSEGM 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  94 LDRGREKIEQAGLAARIALQRADAADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVVLEFSTPRTTPIK 173
Cdd:PRK00216   89 LAVGREKLRDLGLSGNVEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGRLVILEFSKPTNPPLK 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1475473643 174 QLYAWYSRHVLPRIGGLLSPDQGAYEYLPSSVAAFPDGVDFLRRMEGAGFVDLTWTPLTFGIASLYTGR 242
Cdd:PRK00216  169 KAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRYRNLTGGIVALHVGY 237
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 19-241 6.16e-90

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 264.89  E-value: 6.16e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  19 VESMFDAVAPRYDLLNRVLSAGIDRYWRSRAVRTLRAEQPRRVLDVATGTADLALK-AQRTLHPRETIGIDLSAKMLDRG 97
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLNDLLSFGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIElAKSAPDRGKVTGVDFSSEMLEVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  98 REKieqAGLAARIALQRADAADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVVLEFSTPRTTPIKQLYA 177
Cdd:TIGR01934  81 KKK---SELPLNIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEFSKPANALLKKFYK 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1475473643 178 WYSRHVLPRIGGLLSPDQGAYEYLPSSVAAFPDGVDFLRRMEGAGFVDLTWTPLTFGIASLYTG 241
Cdd:TIGR01934 158 FYLKNVLPSIGGLISKNAEAYTYLPESIRAFPSQEELAAMLKEAGFEEVRYRSLTFGVAAIHVG 221
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
17-241 1.02e-61

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 193.04  E-value: 1.02e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  17 EAVESMFDAVAPRYDLLNRVLSAGIDRYWRSRAVRTLRAEQPRRVLDVATGTADLALKAQRTLHPR-ETIGIDLSAKMLD 95
Cdd:pfam01209   2 QRVGDVFSSVASKYDLMNDVISFGIHRLWKDFTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSAGSSgKVVGLDINENMLK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  96 RGREKIEQAGLAaRIALQRADAADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVVLEFSTPRTTPIKQL 175
Cdd:pfam01209  82 EGEKKAKEEGKY-NIEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVVCLEFSKPENPLLSQA 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1475473643 176 YAWYSRHVLPRIGGLLSPDQGAYEYLPSSVAAFPDGVDFLRRMEGAGFVDLTWTPLTFGIASLYTG 241
Cdd:pfam01209 161 YELYFKYVMPFMGKMFAKSYKSYQYLQESIRDFPDQKTLASMFEKAGFKSVGYESLTGGIAAIHWG 226
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 23-175 1.22e-34

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 120.87  E-value: 1.22e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  23 FDAVAPRYDLLNRVLSAgidrywrsravrtLRAEQPRRVLDVATGTADLALKAQRtlHPRETIGIDLSAKMLDRGREKIE 102
Cdd:COG2226     1 FDRVAARYDGREALLAA-------------LGLRPGARVLDLGCGTGRLALALAE--RGARVTGVDISPEMLELARERAA 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1475473643 103 QAGLaaRIALQRADAADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVVLEFSTPRTTPIKQL 175
Cdd:COG2226    66 EAGL--NVEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEEL 136
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 20-223 1.40e-24

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 98.04  E-value: 1.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  20 ESMFDAVAPRYDLLNRVLSAGIDRYWRSRAVRTLRAEQPRRVLDVATGTADLA-LKAQRTLHPRETIGIDLSAKMLDRG- 97
Cdd:PLN02233   36 QALFNRIAPVYDNLNDLLSLGQHRIWKRMAVSWSGAKMGDRVLDLCCGSGDLAfLLSEKVGSDGKVMGLDFSSEQLAVAa 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  98 -REKIEQAGLAARIALQRADAADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVVLEFSTPRTTPIKQLY 176
Cdd:PLN02233  116 sRQELKAKSCYKNIEWIEGDATDLPFDDCYFDAITMGYGLRNVVDRLKAMQEMYRVLKPGSRVSILDFNKSTQPFTTSMQ 195

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1475473643 177 AWYSRH-VLPRIGGLLSPDQgaYEYLPSSVAAFPDGVDFLRRMEGAGF 223
Cdd:PLN02233  196 EWMIDNvVVPVATGYGLAKE--YEYLKSSINEYLTGEELEKLALEAGF 241
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 61-157 2.41e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 90.32  E-value: 2.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  61 VLDVATGTADLALKAQRtLHPRETIGIDLSAKMLDRGREKIEQAGLaaRIALQRADAADLPFDDGAFDAAFV--AFGVRN 138
Cdd:pfam13649   1 VLDLGCGTGRLTLALAR-RGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLPFPDGSFDLVVSsgVLHHLP 77

                          90
                  ....*....|....*....
gi 1475473643 139 FEDLDAGLGDIRRVLRPGG 157
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
16-168 2.63e-19

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 82.35  E-value: 2.63e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  16 AEAVESMFDAVAPRYD--LLNRVLSAGIDRYwRSRAVRTLRAEQPRRVLDVA--TGTADLALKAqrtlHPRETIGIDLSA 91
Cdd:COG4976     4 DAYVEALFDQYADSYDaaLVEDLGYEAPALL-AEELLARLPPGPFGRVLDLGcgTGLLGEALRP----RGYRLTGVDLSE 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1475473643  92 KMLDRGREKieqaglAARIALQRADAADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVvleFSTPR 168
Cdd:COG4976    79 EMLAKAREK------GVYDRLLVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFI---FSVED 146
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 62-161 2.65e-18

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 76.93  E-value: 2.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  62 LDVATGTADLALKAQRtlHPRETIGIDLSAKMLDRGREKIEQAGLAariaLQRADAADLPFDDGAFDAAFVAFGVRNFED 141
Cdd:pfam08241   1 LDVGCGTGLLTELLAR--LGARVTGVDISPEMLELAREKAPREGLT----FVVGDAEDLPFPDNSFDLVLSSEVLHHVED 74

                          90       100
                  ....*....|....*....|
gi 1475473643 142 LDAGLGDIRRVLRPGGALVV 161
Cdd:pfam08241  75 PERALREIARVLKPGGILII 94
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 42-168 1.17e-17

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 76.21  E-value: 1.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  42 DRYWRSRAVRTLR--AEQPRRVLDVATGTADLALKAQRTLHprETIGIDLSAKMLDRGREKIEQAglaaRIALQRADAAD 119
Cdd:COG2227     7 RDFWDRRLAALLArlLPAGGRVLDVGCGTGRLALALARRGA--DVTGVDISPEALEIARERAAEL----NVDFVQGDLED 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1475473643 120 LPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVvleFSTPR 168
Cdd:COG2227    81 LPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLL---LSTPN 126
PRK08317 PRK08317
hypothetical protein; Provisional
 43-164 5.47e-17

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 77.28  E-value: 5.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  43 RYWRSRAVRTLRAEQPRRVLDVATGTADLALK-AQRTLHPRETIGIDLSAKMLDRGREKIEQAGLaaRIALQRADAADLP 121
Cdd:PRK08317    5 RRYRARTFELLAVQPGDRVLDVGCGPGNDARElARRVGPEGRVVGIDRSEAMLALAKERAAGLGP--NVEFVRGDADGLP 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1475473643 122 FDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVVLEF 164
Cdd:PRK08317   83 FPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDT 125
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 48-161 1.11e-16

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 74.58  E-value: 1.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  48 RAVRTLRAEQPRRVLDVATGTADLALKAQRTLHpRETIGIDLSAKMLDRGREKIEQAGLAARIALQRADAADLPFdDGAF 127
Cdd:COG2230    42 LILRKLGLKPGMRVLDIGCGWGGLALYLARRYG-VRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPA-DGQF 119

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1475473643 128 DA-----AFVAFGVRNFEDLdagLGDIRRVLRPGGALVV 161
Cdd:COG2230   120 DAivsigMFEHVGPENYPAY---FAKVARLLKPGGRLLL 155
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
57-161 1.43e-14

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 67.16  E-value: 1.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  57 QPRRVLDVATGTADLALKAQRTLHPRETIGIDLSAKMLDRGREKieqaglAARIALQRADAADLPFdDGAFDAAFVAFGV 136
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARAR------LPNVRFVVADLRDLDP-PEPFDLVVSNAAL 73

                          90       100
                  ....*....|....*....|....*
gi 1475473643 137 RNFEDLDAGLGDIRRVLRPGGALVV 161
Cdd:COG4106    74 HWLPDHAALLARLAAALAPGGVLAV 98
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 60-165 1.26e-13

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 66.29  E-value: 1.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  60 RVLDVATGTADLALKAQRTLHPR-ETIGIDLSAKMLDRGREKIEQAGLAaRIALQRADAADLP--FDDGAFDAAFvAFGV 136
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEELGPNaEVVGIDISEEAIEKARENAQKLGFD-NVEFEQGDIEELPelLEDDKFDVVI-SNCV 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 1475473643 137 RN-FEDLDAGLGDIRRVLRPGGALVVLEFS 165
Cdd:pfam13847  84 LNhIPDPDKVLQEILRVLKPGGRLIISDPD 113
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 54-161 4.69e-12

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 63.01  E-value: 4.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  54 RAEQPRRVLDVATGTADLALKAQRTLHPReTIGIDLSAKMLDRGREKIEQAGLaARIALQRADAADL-PFDDGAFDAAFv 132
Cdd:COG0500    23 RLPKGGRVLDLGCGTGRNLLALAARFGGR-VIGIDLSPEAIALARARAAKAGL-GNVEFLVADLAELdPLPAESFDLVV- 99

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1475473643 133 AFGV---RNFEDLDAGLGDIRRVLRPGGALVV 161
Cdd:COG0500   100 AFGVlhhLPPEEREALLRELARALKPGGVLLL 131
PRK05785 PRK05785
hypothetical protein; Provisional
 17-209 2.64e-11

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 61.24  E-value: 2.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  17 EAVESMFDAVAPRYDLLNRVLSAGIDRYWRSRAVRTL--RAEQPRRVLDVATGTADLALKAqRTLHPRETIGIDLSAKML 94
Cdd:PRK05785    9 EELQEAYNKIPKAYDRANRFISFNQDVRWRAELVKTIlkYCGRPKKVLDVAAGKGELSYHF-KKVFKYYVVALDYAENML 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  95 drgrekieqagLAARIALQRADAA--DLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRpgGALVVLEFSTPRTTPI 172
Cdd:PRK05785   88 -----------KMNLVADDKVVGSfeALPFRDKSFDVVMSSFALHASDNIEKVIAEFTRVSR--KQVGFIAMGKPDNVIK 154

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1475473643 173 KQLYAWYSRHVLPRIGGLLSPDQGAYEYLPSSVAAFP 209
Cdd:PRK05785  155 RKYLSFYLRYIMPYIACLAGAKCRDYKYIYYIYERLP 191
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 85-223 3.82e-11

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 59.70  E-value: 3.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  85 IGIDLSAKMLDRG--REKIEQAGLAARIALQRADAADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVVL 162
Cdd:PLN02232    1 MGLDFSSEQLAVAatRQSLKARSCYKCIEWIEGDAIDLPFDDCEFDAVTMGYGLRNVVDRLRAMKEMYRVLKPGSRVSIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1475473643 163 EFSTPRTTPIKQLYAWYSRHVLPRIGGLLSPDQgAYEYLPSSVAAFPDGVDFLRRMEGAGF 223
Cdd:PLN02232   81 DFNKSNQSVTTFMQGWMIDNVVVPVATVYDLAK-EYEYLKYSINGYLTGEELETLALEAGF 140
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 60-161 4.44e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.21  E-value: 4.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  60 RVLDVATGTADLALKAQRtLHPRETIGIDLSAKMLDRGReKIEQAGLAARIALQRADAADLPFD-DGAFDAAFVAFGVR- 137
Cdd:cd02440     1 RVLDLGCGTGALALALAS-GPGARVTGVDISPVALELAR-KAAAALLADNVEVLKGDAEELPPEaDESFDVIISDPPLHh 78

                          90       100
                  ....*....|....*....|....
gi 1475473643 138 NFEDLDAGLGDIRRVLRPGGALVV 161
Cdd:cd02440    79 LVEDLARFLEEARRLLKPGGVLVL 102
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 54-162 2.40e-10

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 57.65  E-value: 2.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  54 RAEQPRRVLDVATGTADLALKAQrtLHPRETIGIDLSAKMLDRGREKIEQAGLAaRIALQRADAADLPFDDGAFDAA--- 130
Cdd:COG1041    23 GAKEGDTVLDPFCGTGTILIEAG--LLGRRVIGSDIDPKMVEGARENLEHYGYE-DADVIRGDARDLPLADESVDAIvtd 99

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1475473643 131 -----FVAFGVRNFEDLDAG-LGDIRRVLRPGGALVVL 162
Cdd:COG1041   100 ppygrSSKISGEELLELYEKaLEEAARVLKPGGRVVIV 137
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 62-159 5.44e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 55.07  E-value: 5.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  62 LDVATGTADLALKAQRTLHPRETIGIDLSAKMLDRGREKIEQAGL--AARIALQRADAADLpfDDGAFDAAFVAFGVRNF 139
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLlnAVRVELFQLDLGEL--DPGSFDVVVASNVLHHL 78

                          90       100
                  ....*....|....*....|
gi 1475473643 140 EDLDAGLGDIRRVLRPGGAL 159
Cdd:pfam08242  79 ADPRAVLRNIRRLLKPGGVL 98
PLN02244 PLN02244
tocopherol O-methyltransferase
 41-161 8.89e-09

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 54.75  E-value: 8.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  41 IDRYWRSRAVRTLRAEQPRRVLDVATGTAD----LALKAQRtlhprETIGIDLSAKMLDRGREKIEQAGLAARIALQRAD 116
Cdd:PLN02244  102 IEESLAWAGVPDDDEKRPKRIVDVGCGIGGssryLARKYGA-----NVKGITLSPVQAARANALAAAQGLSDKVSFQVAD 176

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1475473643 117 AADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGALVV 161
Cdd:PLN02244  177 ALNQPFEDGQFDLVWSMESGEHMPDKRKFVQELARVAAPGGRIII 221
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 53-161 3.15e-07

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 49.03  E-value: 3.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  53 LRAEQPRRVLDVATGT-------AdLALKAQRTLhpretIGIDLSAKMLDRGREKIEQAGLAARIALQRADAAD-LP-FD 123
Cdd:COG4122    12 ARLLGAKRILEIGTGTgystlwlA-RALPDDGRL-----TTIEIDPERAAIARENFARAGLADRIRLILGDALEvLPrLA 85

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1475473643 124 DGAFDAAFV-AFGVRNFEDLDAglgdIRRVLRPGGALVV 161
Cdd:COG4122    86 DGPFDLVFIdADKSNYPDYLEL----ALPLLRPGGLIVA 120
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 87-195 1.01e-06

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 48.22  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  87 IDLSAKMLDRGREKieqagLAARIALQrADAADLPFDDGAFDAAFVAFGVRNFEDLDAGLGDIRRVLRPGGalvVLEFST 166
Cdd:PRK10258   70 LDLSPPMLAQARQK-----DAADHYLA-GDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGG---VVAFTT 140

                          90       100       110
                  ....*....|....*....|....*....|
gi 1475473643 167 PRTTPIKQLY-AWYSRHVLPRIGGLLSPDQ 195
Cdd:PRK10258  141 LVQGSLPELHqAWQAVDERPHANRFLPPDA 170
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 23-191 1.86e-06

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 47.71  E-value: 1.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  23 FDAVAPRYDLLNRVLSAGIDRYW---------------------RSRAVRTLRAEQPRRVLDVATGTADLALKAQRtLHP 81
Cdd:pfam02353   6 AENIQAHYDLSNDFFALFLDPTMtyscayferpdmtleeaqqakLDLILDKLGLKPGMTLLDIGCGWGGLMRRAAE-RYD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  82 RETIGIDLSAKMLDRGREKIEQAGLAARIALQRADAADLpfdDGAFDA-----AFVAFGVRNFEDLDAGLgdiRRVLRPG 156
Cdd:pfam02353  85 VNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDF---DEPFDRivsvgMFEHVGHENYDTFFKKL---YNLLPPG 158

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1475473643 157 GaLVVLEFST---PRTTPIKQL-YAWYSRHVLPriGGLL 191
Cdd:pfam02353 159 G-LMLLHTITglhPDETSERGLpLKFIDKYIFP--GGEL 194
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
59-172 2.10e-06

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 47.03  E-value: 2.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643   59 RRVLDVATGTA-DLALKAQRTLHpRETIGIDLSAKMLDRGREKIEQAGLAARIALQRADAADLPFDDgAFDAAF---VAF 134
Cdd:smart00828   1 KRVLDFGCGYGsDLIDLAERHPH-LQLHGYTISPEQAEVGRERIRALGLQGRIRIFYRDSAKDPFPD-TYDLVFgfeVIH 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1475473643  135 GVRNFEDLdagLGDIRRVLRPGGALVVLEFSTPRTTPI 172
Cdd:smart00828  79 HIKDKMDL---FSNISRHLKDGGHLVLADFIANLLSAI 113
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 43-223 1.04e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 44.34  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  43 RYWRSRAVRTLRAE------QPRRVLDVATGTADLALKAQRtlHPRETIGIDLSAKMLDRGREKIEQAGlaarialqrAD 116
Cdd:pfam13489   2 AHQRERLLADLLLRllpklpSPGRVLDFGCGTGIFLRLLRA--QGFSVTGVDPSPIAIERALLNVRFDQ---------FD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643 117 AADLPFDDGAFDAAfVAFGV-RNFEDLDAGLGDIRRVLRPGGalvVLEFSTPrttpikqLYAWYSRHVLPRIGGLLSPDQ 195
Cdd:pfam13489  71 EQEAAVPAGKFDVI-VAREVlEHVPDPPALLRQIAALLKPGG---LLLLSTP-------LASDEADRLLLEWPYLRPRNG 139

                         170       180
                  ....*....|....*....|....*...
gi 1475473643 196 GAYeylpssvaaFPDGVDFLRRMEGAGF 223
Cdd:pfam13489 140 HIS---------LFSARSLKRLLEEAGF 158
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 49-161 2.07e-05

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 44.76  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  49 AVRTLRAEQPRRVLDVATGT---AdLALKAQRtlhPRETI-GIDLSAKMLDRGREKIEQAGLAARIALQRADAADLPFDD 124
Cdd:COG2890   104 ALALLPAGAPPRVLDLGTGSgaiA-LALAKER---PDARVtAVDISPDALAVARRNAERLGLEDRVRFLQGDLFEPLPGD 179

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1475473643 125 GAFD-------------AAFVAFGVRNFED---LDA---GLGDIRRV-------LRPGGALVV 161
Cdd:COG2890   180 GRFDlivsnppyipedeIALLPPEVRDHEPrlaLDGgedGLDFYRRIiaqaprlLKPGGWLLL 242
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 54-128 5.40e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 43.21  E-value: 5.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  54 RAEQPRRVLDVATGT--ADLALkAQRTlhPRETI-GIDLSAKMLDRGREKIEQAGLAARIALQRADAADLP--FDDGAFD 128
Cdd:COG4123    34 PVKKGGRVLDLGTGTgvIALML-AQRS--PGARItGVEIQPEAAELARRNVALNGLEDRITVIHGDLKEFAaeLPPGSFD 110
arsM PRK11873
arsenite methyltransferase;
60-230 8.81e-04

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 39.55  E-value: 8.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  60 RVLDVATGTA-DLALKAQRTLHPRETIGIDLSAKMLDRGREKIEQAGlAARIALQRADAADLPFDDGAFDaAFVAFGVRN 138
Cdd:PRK11873   80 TVLDLGSGGGfDCFLAARRVGPTGKVIGVDMTPEMLAKARANARKAG-YTNVEFRLGEIEALPVADNSVD-VIISNCVIN 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643 139 FE-DLDAGLGDIRRVLRPGGAL----VVLEFSTPRTtpIKQ---LYAwysrhvlpriggllspdqgayeylpSSVAAFPD 210
Cdd:PRK11873  158 LSpDKERVFKEAFRVLKPGGRFaisdVVLRGELPEE--IRNdaeLYA-------------------------GCVAGALQ 210

                         170       180
                  ....*....|....*....|
gi 1475473643 211 GVDFLRRMEGAGFVDLTWTP 230
Cdd:PRK11873  211 EEEYLAMLAEAGFVDITIQP 230
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 59-160 1.94e-03

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 39.01  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  59 RRVLDV--ATGTADL-ALKAqrtlHPRETIGIDLSAKMLDRGREKIEQAGLAARIALQRADA----ADLPFDDGAFDAAF 131
Cdd:COG1092   218 KRVLNLfsYTGGFSVhAAAG----GAKSVTSVDLSATALEWAKENAALNGLDDRHEFVQADAfdwlRELAREGERFDLII 293

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1475473643 132 V---AFgVRNFEDLDAGLGDIR-------RVLRPGGALV 160
Cdd:COG1092   294 LdppAF-AKSKKDLFDAQRDYKdlnrlalKLLAPGGILV 331
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 60-157 2.24e-03

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 38.72  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  60 RVLDVATGTADLALKAQRTLHPRETIGIDLSAKMLDRGREKIEQAGlaarIALQRADAADLPFDDGAFDAAFVAFGVRNF 139
Cdd:PLN02490  116 KVVDVGGGTGFTTLGIVKHVDAKNVTILDQSPHQLAKAKQKEPLKE----CKIIEGDAEDLPFPTDYADRYVSAGSIEYW 191

                          90
                  ....*....|....*...
gi 1475473643 140 EDLDAGLGDIRRVLRPGG 157
Cdd:PLN02490  192 PDPQRGIKEAYRVLKIGG 209
Methyltransf_20 pfam12147
Putative methyltransferase; This domain is found in bacteria and eukaryotes and is ...
 48-160 3.47e-03

Putative methyltransferase; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The family shows homology to methyltransferases.


Pssm-ID: 432362  Cd Length: 309  Bit Score: 38.13  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1475473643  48 RAVRTLRAE-QPRRVLDVATGTADLALKAQRTlHPRETIGI---DLSAKMLDRGREKIEQAGLAARIALQRADA---ADL 120
Cdd:pfam12147 123 QAIARLRAKgQPVRILDIAAGHGRYVLEALAK-LPQRPESIllrDYSPLNVEQGNALIAAKGLEDIARFEQGDAfdpDSL 201

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1475473643 121 PFDDGAFDAAFVAFGVRNFEDLD---AGLGDIRRVLRPGGALV 160
Cdd:pfam12147 202 AALTPQPTLAIVSGLYELFPDNDlvrRSLAGLAAAVEPGGYLI 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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