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Conserved domains on  [gi|1492573121|ref|WP_120832465|]
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plasminogen-binding protein PgbB [Helicobacter pylori]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PGBA_C pfam15437
Plasminogen-binding protein pgbA C-terminal; PGBA_C is an C-terminal family of bacterial ...
 458-541 3.69e-38

Plasminogen-binding protein pgbA C-terminal; PGBA_C is an C-terminal family of bacterial proteins that bind plasminogen. This activity was identified in Helicobacter pylori where it is thought to contribute to the virulence of this bacterium. Both PgbA and PgbB are surface-exposed proteins that mediate binding to plasminogen such that it can be converted into plasmin in the presence of a plasminogen activator.


:

Pssm-ID: 292077 [Multi-domain]  Cd Length: 84  Bit Score: 134.84  E-value: 3.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 458 NNAIQQGETKNNESKNAPVLKENATKKEAPKPNSKEEKRRLKEERKKAKAEQRAREFEQRAREHQERDEKELEERRKALE 537
Cdd:pfam15437   1 NNATQQGETKNNEKKNAPVLKENAAKKEENKPNSKEEKRRLKEEKKKAKAEQRAREFEQRAREHQERDEKELEERRKALE 80


                  ....
gi 1492573121 538 MNKK 541
Cdd:pfam15437  81 AGKK 84
 
Name Accession Description Interval E-value
PGBA_C pfam15437
Plasminogen-binding protein pgbA C-terminal; PGBA_C is an C-terminal family of bacterial ...
 458-541 3.69e-38

Plasminogen-binding protein pgbA C-terminal; PGBA_C is an C-terminal family of bacterial proteins that bind plasminogen. This activity was identified in Helicobacter pylori where it is thought to contribute to the virulence of this bacterium. Both PgbA and PgbB are surface-exposed proteins that mediate binding to plasminogen such that it can be converted into plasmin in the presence of a plasminogen activator.


Pssm-ID: 292077 [Multi-domain]  Cd Length: 84  Bit Score: 134.84  E-value: 3.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 458 NNAIQQGETKNNESKNAPVLKENATKKEAPKPNSKEEKRRLKEERKKAKAEQRAREFEQRAREHQERDEKELEERRKALE 537
Cdd:pfam15437   1 NNATQQGETKNNEKKNAPVLKENAAKKEENKPNSKEEKRRLKEEKKKAKAEQRAREFEQRAREHQERDEKELEERRKALE 80


                  ....
gi 1492573121 538 MNKK 541
Cdd:pfam15437  81 AGKK 84
PTZ00121 PTZ00121
MAEBL; Provisional
 417-541 3.14e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 56.69  E-value: 3.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  417 QERHKVKENKQPLEENKVKPRNSGFEEEEVKtRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKPNSK-EEK 495
Cdd:PTZ00121  1312 EEAKKADEAKKKAEEAKKKADAAKKKAEEAK-KAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKaEEK 1390

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1492573121  496 RRLKEERKKA-KAEQRAREFEQRAREHQERDE--KELEERRKALEMNKK 541
Cdd:PTZ00121  1391 KKADEAKKKAeEDKKKADELKKAAAAKKKADEakKKAEEKKKADEAKKK 1439
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 454-541 4.41e-08

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 55.24  E-value: 4.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 454 IKDQNNAIQQGEtKNNESKNAPVLKENATKKEAPKPNSKEEKRRLKEERKKAKAEQRAREFEQRAREHQERDEKELEERR 533
Cdd:TIGR02794  48 VAQQANRIQQQK-KPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKA 126


                  ....*...
gi 1492573121 534 KALEMNKK 541
Cdd:TIGR02794 127 KQAAEAKA 134
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
417-535 6.19e-04

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 42.33  E-value: 6.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 417 QERHKVKENKQPLEENKVKPRNSgfEEEEVKTRRSEPIKDQNNAIQQGET--KNNESKNAPVLKENATKKEAPKPNSKEE 494
Cdd:COG3064    41 EERLAELEAKRQAEEEAREAKAE--AEQRAAELAAEAAKKLAEAEKAAAEaeKKAAAEKAKAAKEAEAAAAAEKAAAAAE 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1492573121 495 KRRLKEERKKA------KAEQRAREFEQRAREHQERDEKELEERRKA 535
Cdd:COG3064   119 KEKAEEAKRKAeeeakrKAEEERKAAEAEAAAKAEAEAARAAAAAAA 165
 
Name Accession Description Interval E-value
PGBA_C pfam15437
Plasminogen-binding protein pgbA C-terminal; PGBA_C is an C-terminal family of bacterial ...
 458-541 3.69e-38

Plasminogen-binding protein pgbA C-terminal; PGBA_C is an C-terminal family of bacterial proteins that bind plasminogen. This activity was identified in Helicobacter pylori where it is thought to contribute to the virulence of this bacterium. Both PgbA and PgbB are surface-exposed proteins that mediate binding to plasminogen such that it can be converted into plasmin in the presence of a plasminogen activator.


Pssm-ID: 292077 [Multi-domain]  Cd Length: 84  Bit Score: 134.84  E-value: 3.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 458 NNAIQQGETKNNESKNAPVLKENATKKEAPKPNSKEEKRRLKEERKKAKAEQRAREFEQRAREHQERDEKELEERRKALE 537
Cdd:pfam15437   1 NNATQQGETKNNEKKNAPVLKENAAKKEENKPNSKEEKRRLKEEKKKAKAEQRAREFEQRAREHQERDEKELEERRKALE 80


                  ....
gi 1492573121 538 MNKK 541
Cdd:pfam15437  81 AGKK 84
PTZ00121 PTZ00121
MAEBL; Provisional
 417-541 3.14e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 56.69  E-value: 3.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  417 QERHKVKENKQPLEENKVKPRNSGFEEEEVKtRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKPNSK-EEK 495
Cdd:PTZ00121  1312 EEAKKADEAKKKAEEAKKKADAAKKKAEEAK-KAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKaEEK 1390

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1492573121  496 RRLKEERKKA-KAEQRAREFEQRAREHQERDE--KELEERRKALEMNKK 541
Cdd:PTZ00121  1391 KKADEAKKKAeEDKKKADELKKAAAAKKKADEakKKAEEKKKADEAKKK 1439
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 454-541 4.41e-08

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 55.24  E-value: 4.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 454 IKDQNNAIQQGEtKNNESKNAPVLKENATKKEAPKPNSKEEKRRLKEERKKAKAEQRAREFEQRAREHQERDEKELEERR 533
Cdd:TIGR02794  48 VAQQANRIQQQK-KPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKA 126


                  ....*...
gi 1492573121 534 KALEMNKK 541
Cdd:TIGR02794 127 KQAAEAKA 134
PTZ00121 PTZ00121
MAEBL; Provisional
 416-541 8.20e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 8.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  416 LQERHKVKENKQPLEENKVKPRNSGFEEeevkTRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKPNSKEEK 495
Cdd:PTZ00121  1226 AEAVKKAEEAKKDAEEAKKAEEERNNEE----IRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEK 1301

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1492573121  496 RRLKEERKKAKAEQRAREFEQRAREHQERDE---KELEERRKALEMNKK 541
Cdd:PTZ00121  1302 KKADEAKKKAEEAKKADEAKKKAEEAKKKADaakKKAEEAKKAAEAAKA 1350
PTZ00121 PTZ00121
MAEBL; Provisional
 417-540 9.33e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.15  E-value: 9.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  417 QERHKVKENKQPLEENKVKPRNSGFEEEEVKTRRSEPIKDQNNAIQQGETKNN---ESKNAPVLK---ENATKKEAPKPN 490
Cdd:PTZ00121  1617 EAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKaeeDKKKAEEAKkaeEDEKKAAEALKK 1696

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1492573121  491 SKEEKRRLKEERKKA-----KAEQRAREFEQRAREHQERDEKELEERRKALEMNK 540
Cdd:PTZ00121  1697 EAEEAKKAEELKKKEaeekkKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKK 1751
PTZ00121 PTZ00121
MAEBL; Provisional
 417-541 3.99e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.22  E-value: 3.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  417 QERHKVKENKQPLEENKVKPRNSGFEEEEVKTRRSEPIKDQNNAIQQgetKNNESKNAPVLKENA--TKKEAPKPNSKEE 494
Cdd:PTZ00121  1339 EEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKK---KAEEKKKADEAKKKAeeDKKKADELKKAAA 1415

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1492573121  495 -KRRLKEERKKAKAEQRAREFEQRAREHQERDE--KELEERRKALEMNKK 541
Cdd:PTZ00121  1416 aKKKADEAKKKAEEKKKADEAKKKAEEAKKADEakKKAEEAKKAEEAKKK 1465
PTZ00121 PTZ00121
MAEBL; Provisional
 414-540 4.24e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.22  E-value: 4.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  414 IYLQERHKVKENKQPLEENKVKPRNSGFEEEEVKTRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKPNSKE 493
Cdd:PTZ00121  1600 LYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEE 1679

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1492573121  494 EKRRLKEERKKAKAEQRArefEQRAREHQERDEKELEERRKALEMNK 540
Cdd:PTZ00121  1680 AKKAEEDEKKAAEALKKE---AEEAKKAEELKKKEAEEKKKAEELKK 1723
PTZ00121 PTZ00121
MAEBL; Provisional
 417-540 7.21e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.45  E-value: 7.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  417 QERHKVKENKQPLEENKVKPRNSGFEEEEVKtrRSEPIKDQNNAIQQGE---TKNNESKNAPVLKENATKKEAPKPNSK- 492
Cdd:PTZ00121  1388 EEKKKADEAKKKAEEDKKKADELKKAAAAKK--KADEAKKKAEEKKKADeakKKAEEAKKADEAKKKAEEAKKAEEAKKk 1465

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1492573121  493 -EEKRRLKEERKKAKAEQRAREFEQRAREHQERDE---KELEERRKALEMNK 540
Cdd:PTZ00121  1466 aEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADeakKAAEAKKKADEAKK 1517
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 405-537 8.21e-07

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 51.49  E-value: 8.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 405 QKGEKGNAPIYLQERHKVKEN---KQPLEENKVKPrnsgfEEEEVKTRRSEPIKDQNNAIQQGETKNN-ESKNAPVLKEN 480
Cdd:pfam15709 369 ERAEKMREELELEQQRRFEEIrlrKQRLEEERQRQ-----EEEERKQRLQLQAAQERARQQQEEFRRKlQELQRKKQQEE 443

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1492573121 481 ATKKEAPKPNSKEEKRRLKEERKK--AKAEQRAREFEQRAREHQERDEKELEERRKALE 537
Cdd:pfam15709 444 AERAEAEKQRQKELEMQLAEEQKRlmEMAEEERLEYQRQKQEAEEKARLEAEERRQKEE 502
PTZ00121 PTZ00121
MAEBL; Provisional
 417-540 1.94e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.91  E-value: 1.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  417 QERHKVKENKQPLEENKVKPRNSGFEEEEVKTRRSEPIKDQNNAIQQGETKNNESKNAPVLK---ENATKKEAPKPNSKE 493
Cdd:PTZ00121  1415 AAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKkkaEEAKKADEAKKKAEE 1494

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1492573121  494 EKRRLKEERKKAKAEQRAREFeQRAREHQERDE-KELEERRKALEMNK 540
Cdd:PTZ00121  1495 AKKKADEAKKAAEAKKKADEA-KKAEEAKKADEaKKAEEAKKADEAKK 1541
CAF-1_p150 pfam11600
Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide ...
 417-535 3.68e-06

Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesized and acetylated histones H3/H4 into chromatin during DNA replication and repair. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesized and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis.


Pssm-ID: 402959 [Multi-domain]  Cd Length: 164  Bit Score: 47.38  E-value: 3.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 417 QERHKVKENKQPLEENKVKPRNSGF----EEEEVKTRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKpNSK 492
Cdd:pfam11600   4 QKSVQSQEEKEKQRLEKDKERLRRQlkleAEKEEKERLKEEAKAEKERAKEEARRKKEEEKELKEKERREKKEKDE-KEK 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1492573121 493 EEKRRLKEERKKAKAEQRAREFEQRAREHQERDEKELEERRKA 535
Cdd:pfam11600  83 AEKLRLKEEKRKEKQEALEAKLEEKRKKEEEKRLKEEEKRIKA 125
PTZ00121 PTZ00121
MAEBL; Provisional
 418-541 6.05e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 6.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  418 ERHKVKENKQPLEENKVKPRNSGFEEEEVKTRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKPNSKEEKRR 497
Cdd:PTZ00121  1590 EEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKK 1669

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1492573121  498 LKEERKKAKAEQRAREFEQRAREHQERDEkelEERRKALEMNKK 541
Cdd:PTZ00121  1670 AEEDKKKAEEAKKAEEDEKKAAEALKKEA---EEAKKAEELKKK 1710
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 417-541 1.16e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 48.20  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 417 QERH-KVKENKQPLEENKVKPRNSGFEE----EEVKTRRSEPIKDQNNAIQQG------ETKNNESKNAPVLKENATKKE 485
Cdd:pfam17380 409 EERQrKIQQQKVEMEQIRAEQEEARQREvrrlEEERAREMERVRLEEQERQQQverlrqQEEERKRKKLELEKEKRDRKR 488

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1492573121 486 APKPNSKEEKRRLKEERKKAKAEQRAR-----EFEQRAR---EHQERDEKElEERRKALEMNKK 541
Cdd:pfam17380 489 AEEQRRKILEKELEERKQAMIEEERKRkllekEMEERQKaiyEEERRREAE-EERRKQQEMEER 551
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 405-535 1.19e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 47.88  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 405 QKGEKGNAPIYLQERHKVKENKQP-LEENKVKprnsgfEEEEVKTRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATK 483
Cdd:PRK09510   67 QQQQQKSAKRAEEQRKKKEQQQAEeLQQKQAA------EQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAK 140

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1492573121 484 -KEAPKPNSKEEKRRLKEERKKAKAEQRAREFEQRAREHQERDEKELEERRKA 535
Cdd:PRK09510  141 aAAAAKAKAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAA 193
PTZ00121 PTZ00121
MAEBL; Provisional
 417-540 1.93e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.83  E-value: 1.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  417 QERHKVKENKQPLEENKvKPRNSGFEEEEvkTRRSEPIKdqnnaiqqgeTKNNESKNAPVLKENA--TKKEAPKPNSKEE 494
Cdd:PTZ00121  1441 EEAKKADEAKKKAEEAK-KAEEAKKKAEE--AKKADEAK----------KKAEEAKKADEAKKKAeeAKKKADEAKKAAE 1507

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1492573121  495 KRRLKEERKKAKAEQRAREFeQRAREHQERDE-KELEERRKALEMNK 540
Cdd:PTZ00121  1508 AKKKADEAKKAEEAKKADEA-KKAEEAKKADEaKKAEEKKKADELKK 1553
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 417-538 3.28e-05

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 44.26  E-value: 3.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 417 QERHKVKE-NKQPLEENKVKprnsgfEEEEVKTRRSEPIKDQNnaiqqgETKNNESKNAPVLKENATKKEAPKPNSKEEK 495
Cdd:pfam05672  32 QERLEKEEeERLRKEELRRR------AEEERARREEEARRLEE------ERRREEEERQRKAEEEAEEREQREQEEQERL 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1492573121 496 RRLKEErkkakAEQRAREFEQRAR----EHQERDEKELEERRKALEM 538
Cdd:pfam05672 100 QKQKEE-----AEAKAREEAERQRqereKIMQQEEQERLERKKRIEE 141
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 465-538 6.27e-05

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 45.71  E-value: 6.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 465 ETKNNESKNAP--VLKENATKKEAPKPNSKEE---KRRLKEERK-KAKAEQRAREFEQRAREHQERDEKELEERRKALEM 538
Cdd:pfam15709 310 ESEEERSEEDPskALLEKREQEKASRDRLRAEraeMRRLEVERKrREQEEQRRLQQEQLERAEKMREELELEQQRRFEEI 389
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 500-541 8.65e-05

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 43.11  E-value: 8.65e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1492573121 500 EERKKAKAEQRAREFEQRAREHQERDEKELEERRKALEMNKK 541
Cdd:pfam05672  10 EEAARILAEKRRQAREQREREEQERLEKEEEERLRKEELRRR 51
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 402-541 9.00e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.84  E-value: 9.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 402 KPSQKGEKGNAPIYLQERHKVKENKQPLEENKVKPRNSGFEEEEvKTRRSEPIKDQNNAIQQGEtknnESKNAPVLKENA 481
Cdd:TIGR02794  59 KKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEK-AAKQAEQAAKQAEEKQKQA----EEAKAKQAAEAK 133

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1492573121 482 TKKEA---PKPNSKEEKRRLKEERKKAKAEQRAREFEQRAREHQERDEKELEERRKALEMNKK 541
Cdd:TIGR02794 134 AKAEAeaeRKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKA 196
CAF-1_p150 pfam11600
Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide ...
 449-541 1.04e-04

Chromatin assembly factor 1 complex p150 subunit, N-terminal; CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesized and acetylated histones H3/H4 into chromatin during DNA replication and repair. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesized and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis.


Pssm-ID: 402959 [Multi-domain]  Cd Length: 164  Bit Score: 43.14  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 449 RRSEPIKDQNNAIQQGETKNNESKNAPVLKENATK--KEAPKPNSKEEKRRLKEERKKAKAEQRAREFEQRaREHQERDE 526
Cdd:pfam11600   1 RRSQKSVQSQEEKEKQRLEKDKERLRRQLKLEAEKeeKERLKEEAKAEKERAKEEARRKKEEEKELKEKER-REKKEKDE 79

                          90
                  ....*....|....*
gi 1492573121 527 KELEERRKALEMNKK 541
Cdd:pfam11600  80 KEKAEKLRLKEEKRK 94
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
 442-534 1.12e-04

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 43.54  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 442 EEEEVKTRRS-EPIKD--QNNAIQQGETKNNESKNAPVLKENATKKEAPKPNSKEE-KRRLKE-ERKKAKAEQRAREFEQ 516
Cdd:pfam13904  84 QEAELRKRLAkEKYQEwlQRKARQQTKKREESHKQKAAESASKSLAKPERKVSQEEaKEVLQEwERKKLEQQQRKREEEQ 163

                          90
                  ....*....|....*...
gi 1492573121 517 RAREHQERdekELEERRK 534
Cdd:pfam13904 164 REQLKKEE---EEQERKQ 178
PTZ00121 PTZ00121
MAEBL; Provisional
 417-540 1.13e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.13  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  417 QERHKVKENKQPLEENKVKPRNSGFEE---EEVK----TRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKP 489
Cdd:PTZ00121  1519 EEAKKADEAKKAEEAKKADEAKKAEEKkkaDELKkaeeLKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVM 1598

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1492573121  490 NSKEEKRRL------KEERKKAKAEQRAREFEQRAREHQERdEKELEERRKALEMNK 540
Cdd:PTZ00121  1599 KLYEEEKKMkaeeakKAEEAKIKAEELKKAEEEKKKVEQLK-KKEAEEKKKAEELKK 1654
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 416-541 1.46e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 44.73  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 416 LQERHKVKENKQPLEENKVKPRNsgFEEEEVKTRRSEpikDQNNAIQQGETKnnESKNAPVLKENATK------KEAPKP 489
Cdd:pfam17380 456 QERQQQVERLRQQEEERKRKKLE--LEKEKRDRKRAE---EQRRKILEKELE--ERKQAMIEEERKRKllekemEERQKA 528

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1492573121 490 NSKEEKRRLKEE--RKKAKAEQRAREFEQRAREHQERD-----EKELEERRKALEMNKK 541
Cdd:pfam17380 529 IYEEERRREAEEerRKQQEMEERRRIQEQMRKATEERSrleamEREREMMRQIVESEKA 587
PTZ00121 PTZ00121
MAEBL; Provisional
 412-541 1.53e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 1.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  412 APIYLQERHKVKENKQPLEENKVKprnsgfeeeevKTRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKPNS 491
Cdd:PTZ00121  1270 AAIKAEEARKADELKKAEEKKKAD-----------EAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKA 1338

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1492573121  492 KEEKRrlKEERKKAKAEQRAREFEQRAREHQERDEKELEERRKALEMNKK 541
Cdd:PTZ00121  1339 EEAKK--AAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKK 1386
PTZ00121 PTZ00121
MAEBL; Provisional
 417-540 2.22e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 2.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  417 QERHKVKENKQPLEENKVKPRNSGFEEEEVKTRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKPNSKEEKR 496
Cdd:PTZ00121  1561 EEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKK 1640

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1492573121  497 RLKEERKKAKAEQRAREfEQRAREHQERdEKELEERRKALEMNK 540
Cdd:PTZ00121  1641 KEAEEKKKAEELKKAEE-ENKIKAAEEA-KKAEEDKKKAEEAKK 1682
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 417-537 2.29e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.96  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 417 QERHKVKENKQPLEENKVKPRNSGFEEEEVKTRRSEPIKDQNNAiQQGETKNNESKNAPVLKENATKKEAPKPNSKE--E 494
Cdd:pfam17380 472 RKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKR-KLLEKEMEERQKAIYEEERRREAEEERRKQQEmeE 550

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1492573121 495 KRRLKEERKKAKAEQRAREFEQRAREHQeRDEKELEERRKALE 537
Cdd:pfam17380 551 RRRIQEQMRKATEERSRLEAMEREREMM-RQIVESEKARAEYE 592
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 425-535 2.75e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 43.30  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 425 NKQPLEENKVKPRNsgfEEEEVKTRRSEPIKDQNNAIQQGETKNNESKNApvlKENATKKEAPKPNSKEEKRRLKEERK- 503
Cdd:TIGR02794  53 NRIQQQKKPAAKKE---QERQKKLEQQAEEAEKQRAAEQARQKELEQRAA---AEKAAKQAEQAAKQAEEKQKQAEEAKa 126

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1492573121 504 KAKAEQRAREFEQRAREHQERDEKELEERRKA 535
Cdd:TIGR02794 127 KQAAEAKAKAEAEAERKAKEEAAKQAEEEAKA 158
rne PRK10811
ribonuclease E; Reviewed
 403-541 3.07e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 43.87  E-value: 3.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  403 PSQKGEKGNAPIYLQERHKVKENkQPLEENKVKPRNSGFEEEEVKTRRSEPIKDQNNAIQQGETKNNESKNAPVLKENAT 482
Cdd:PRK10811   590 EQPAPKAEAKPERQQDRRKPRQN-NRRDRNERRDTRDNRTRREGRENREENRRNRRQAQQQTAETRESQQAEVTEKARTQ 668

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1492573121  483 KKEAPKPNsKEEKRRLKEERKKAKAEQRAREFEQRAREHQERDEK--ELEERRKALEMNKK 541
Cdd:PRK10811   669 DEQQQAPR-RERQRRRNDEKRQAQQEAKALNVEEQSVQETEQEERvqQVQPRRKQRQLNQK 728
PTZ00121 PTZ00121
MAEBL; Provisional
 402-541 3.58e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 3.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  402 KPSQKGEKGNAPIYLQERHKVKENKQPLEENKvKPRNSGFEEEEVKtRRSEPIKDQNNAIQQGET--KNNESKNAPVLKE 479
Cdd:PTZ00121  1452 KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAK-KADEAKKKAEEAK-KKADEAKKAAEAKKKADEakKAEEAKKADEAKK 1529

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1492573121  480 NATKKEAPKPNSKEEKRRlKEERKKA----------KAEQRAREFE------QRAREHQERDEKELEERRKALEMNKK 541
Cdd:PTZ00121  1530 AEEAKKADEAKKAEEKKK-ADELKKAeelkkaeekkKAEEAKKAEEdknmalRKAEEAKKAEEARIEEVMKLYEEEKK 1606
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 492-540 3.96e-04

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 41.18  E-value: 3.96e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1492573121 492 KEEKRRLKEER-------KKAKAEQRAREFEQRAREHQERDEKELEERRKALEMNK 540
Cdd:pfam05672  46 EELRRRAEEERarreeeaRRLEEERRREEEERQRKAEEEAEEREQREQEEQERLQK 101
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
417-535 6.19e-04

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 42.33  E-value: 6.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 417 QERHKVKENKQPLEENKVKPRNSgfEEEEVKTRRSEPIKDQNNAIQQGET--KNNESKNAPVLKENATKKEAPKPNSKEE 494
Cdd:COG3064    41 EERLAELEAKRQAEEEAREAKAE--AEQRAAELAAEAAKKLAEAEKAAAEaeKKAAAEKAKAAKEAEAAAAAEKAAAAAE 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1492573121 495 KRRLKEERKKA------KAEQRAREFEQRAREHQERDEKELEERRKA 535
Cdd:COG3064   119 KEKAEEAKRKAeeeakrKAEEERKAAEAEAAAKAEAEAARAAAAAAA 165
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 443-537 7.55e-04

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 40.03  E-value: 7.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 443 EEEVKTRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKPNSKEEKRRlKEERKKAKAEQRAREFEQRAREHQ 522
Cdd:pfam15346  17 EEAVAKRVEEELEKRKDEIEAEVERRVEEARKIMEKQVLEELEREREAELEEERR-KEEEERKKREELERILEENNRKIE 95

                          90
                  ....*....|....*
gi 1492573121 523 ERDEKELEERRKALE 537
Cdd:pfam15346  96 EAQRKEAEERLAMLE 110
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 416-541 7.58e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 42.25  E-value: 7.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 416 LQERHKVKENKQPLEENKVKPRnsgfeEEEVKTRRSEpiKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKPNSK--- 492
Cdd:pfam15709 325 LEKREQEKASRDRLRAERAEMR-----RLEVERKRRE--QEEQRRLQQEQLERAEKMREELELEQQRRFEEIRLRKQrle 397

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1492573121 493 -EEKRRLKEERKKAKAEQRAREfeqRAREHQErdekelEERRKALEMNKK 541
Cdd:pfam15709 398 eERQRQEEEERKQRLQLQAAQE---RARQQQE------EFRRKLQELQRK 438
PTZ00121 PTZ00121
MAEBL; Provisional
 421-540 8.70e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 8.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  421 KVKENKQPLEENKVKPRNSGFEEEEVKtRRSEPIKDQNNAIQQGEtkNNESKNAPVLKENATKKEAPKPNSK-EEKRRLK 499
Cdd:PTZ00121  1358 EAEAAEEKAEAAEKKKEEAKKKADAAK-KKAEEKKKADEAKKKAE--EDKKKADELKKAAAAKKKADEAKKKaEEKKKAD 1434

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1492573121  500 EERKKAKAEQRAREFEQRAREHQERDE--KELEERRKA-------LEMNK 540
Cdd:PTZ00121  1435 EAKKKAEEAKKADEAKKKAEEAKKAEEakKKAEEAKKAdeakkkaEEAKK 1484
PTZ00121 PTZ00121
MAEBL; Provisional
 404-541 9.24e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 9.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  404 SQKGEKGNAPIYLQERHKVKENKQPLEENKVKPRNSGFEEEEVKT-----RRSEPIKDQNNAIQQGETknnESKNAPVLK 478
Cdd:PTZ00121  1348 AKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKadeakKKAEEDKKKADELKKAAA---AKKKADEAK 1424

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1492573121  479 ENAT-KKEAPKPNSKEEKRRLKEERKK-----AKAEqrarEFEQRAREHQERDE--KELEERRKALEMNKK 541
Cdd:PTZ00121  1425 KKAEeKKKADEAKKKAEEAKKADEAKKkaeeaKKAE----EAKKKAEEAKKADEakKKAEEAKKADEAKKK 1491
Casc1_N pfam15927
Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...
 492-541 9.64e-04

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.


Pssm-ID: 464947 [Multi-domain]  Cd Length: 201  Bit Score: 40.42  E-value: 9.64e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1492573121 492 KEEKRRLK---EERKKAKAEQRAREFEQRAREHQERDEKELEERRKALEMNKK 541
Cdd:pfam15927   5 EEEEERLRaeeEEAERLEEERREEEEEERLAAEQDRRAEELEELKHLLEERKE 57
Caldesmon pfam02029
Caldesmon;
417-537 1.49e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 41.39  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 417 QERHKVKENKQPLEENKVKPRNSGFEEEEVKTRRSEPIK---------DQNNAIQQGETKNNESKNAPVL-KENATKKEA 486
Cdd:pfam02029 151 QAEEEGEEEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKvkyeskvflDQKRGHPEVKSQNGEEEVTKLKvTTKRRQGGL 230

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1492573121 487 PKPNSKEEKRRLKEERKKAKAEQRAR-------EFEQRAREHQERdEKELEE-------RRKALE 537
Cdd:pfam02029 231 SQSQEREEEAEVFLEAEQKLEELRRRrqekeseEFEKLRQKQQEA-ELELEElkkkreeRRKLLE 294
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
442-535 2.01e-03

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 40.79  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 442 EEEEVKTRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKP---NSKEEKRRLKE-----ERKKAKAEQRARE 513
Cdd:COG3064     9 AAEAAAQERLEQAEAEKRAAAEAEQKAKEEAEEERLAELEAKRQAEEEareAKAEAEQRAAElaaeaAKKLAEAEKAAAE 88

                          90       100
                  ....*....|....*....|..
gi 1492573121 514 FEQRAREHQERDEKELEERRKA 535
Cdd:COG3064    89 AEKKAAAEKAKAAKEAEAAAAA 110
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
443-541 2.05e-03

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 40.79  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 443 EEEVKTRRSEPIKDQnnAIQQGETKnnESKNAPVLKENATKKEAPKPNSKEEKRRLKEERKKAKAEQrarefEQRAREHQ 522
Cdd:COG3064     2 QEALEEKAAEAAAQE--RLEQAEAE--KRAAAEAEQKAKEEAEEERLAELEAKRQAEEEAREAKAEA-----EQRAAELA 72

                          90
                  ....*....|....*....
gi 1492573121 523 ERDEKELEERRKALEMNKK 541
Cdd:COG3064    73 AEAAKKLAEAEKAAAEAEK 91
Caldesmon pfam02029
Caldesmon;
401-524 2.14e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 40.62  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 401 FKPSQKGEKGNAPiyLQERHKVKENKQPLEENKVKPRNSGFEEEEVKTRRsePIKDQNNAIQQGEtKNNESKNAPVLKEN 480
Cdd:pfam02029  89 FDPTIADEKESVA--ERKENNEEEENSSWEKEEKRDSRLGRYKEEETEIR--EKEYQENKWSTEV-RQAEEEGEEEEDKS 163

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1492573121 481 ATKKEAPKPNSKEEKRRLKEERKKAKAEQRAREFEQRAREHQER 524
Cdd:pfam02029 164 EEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEV 207
PTZ00121 PTZ00121
MAEBL; Provisional
 382-541 2.42e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 2.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  382 RYYLDYNDFKPKLYPHAAGFKPSQKGE---KGNAPIYLQERHKVKENKQPLEENKVKPRNSGFEE----EEVKTRRSEPI 454
Cdd:PTZ00121  1249 RNNEEIRKFEEARMAHFARRQAAIKAEearKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEakkaDEAKKKAEEAK 1328

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  455 KDQNNAIQQGETKNNesknapvlKENATKKEAPKPNSKEEKrrlKEERKKA------KAEQRAREFEQRAREHQERDE-- 526
Cdd:PTZ00121  1329 KKADAAKKKAEEAKK--------AAEAAKAEAEAAADEAEA---AEEKAEAaekkkeEAKKKADAAKKKAEEKKKADEak 1397

                          170
                   ....*....|....*.
gi 1492573121  527 -KELEERRKALEMNKK 541
Cdd:PTZ00121  1398 kKAEEDKKKADELKKA 1413
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 456-541 2.52e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 40.17  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 456 DQNNAIQQgetKNNESKNAPVLKENATKKEAPKPNSKE--EKRRLKE-ERKKAKAEQRAREFEQRAREHQERDEKELEER 532
Cdd:PRK09510   62 EQYNRQQQ---QQKSAKRAEEQRKKKEQQQAEELQQKQaaEQERLKQlEKERLAAQEQKKQAEEAAKQAALKQKQAEEAA 138


                  ....*....
gi 1492573121 533 RKALEMNKK 541
Cdd:PRK09510  139 AKAAAAAKA 147
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 492-534 2.76e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 38.48  E-value: 2.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1492573121 492 KEEKRRLK--EERKKAKAEQRAREFEQRARehQERDEKELEERRK 534
Cdd:pfam05672  29 REEQERLEkeEEERLRKEELRRRAEEERAR--REEEARRLEEERR 71
PLN02316 PLN02316
synthase/transferase
 468-538 3.58e-03

synthase/transferase


Pssm-ID: 215180 [Multi-domain]  Cd Length: 1036  Bit Score: 40.24  E-value: 3.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  468 NNESKNAPVLKENATKKEAPKPNSKEEKRRLKE-------ERKKAKAEQRAREfEQRAREHQERDE--KELEERRKALEM 538
Cdd:PLN02316   227 NNDHKDFCVEIEGGMDEHSFEDFLLEEKRRELEklakeeaERERQAEEQRRRE-EEKAAMEADRAQakAEVEKRREKLQN 305
TolA COG3064
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
417-540 3.78e-03

Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442298 [Multi-domain]  Cd Length: 485  Bit Score: 40.02  E-value: 3.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 417 QERHKVKENKQ----PLEENKVKPRNSGFE-EEEVKTRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKPNS 491
Cdd:COG3064    23 AEKRAAAEAEQkakeEAEEERLAELEAKRQaEEEAREAKAEAEQRAAELAAEAAKKLAEAEKAAAEAEKKAAAEKAKAAK 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1492573121 492 KEEKRrLKEERKKAKAEQRAREfEQRAREHQERDEKeLEERRKALEMNK 540
Cdd:COG3064   103 EAEAA-AAAEKAAAAAEKEKAE-EAKRKAEEEAKRK-AEEERKAAEAEA 148
Casc1_N pfam15927
Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...
 493-537 5.10e-03

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.


Pssm-ID: 464947 [Multi-domain]  Cd Length: 201  Bit Score: 38.50  E-value: 5.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1492573121 493 EEKRRLKEERKKAKAEQRAR-EFEQRAREHQERDEKELEERRKALE 537
Cdd:pfam15927   1 ARLREEEEERLRAEEEEAERlEEERREEEEEERLAAEQDRRAEELE 46
Caldesmon pfam02029
Caldesmon;
403-536 5.18e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 39.47  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 403 PSQKGEKGNapiYLQERHKVKENKQPLEENKVKPRnSGFEEEEVKT-RRSEPIKDQNNAIQQGETKNNESKNApvlkENA 481
Cdd:pfam02029 205 PEVKSQNGE---EEVTKLKVTTKRRQGGLSQSQER-EEEAEVFLEAeQKLEELRRRRQEKESEEFEKLRQKQQ----EAE 276

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1492573121 482 TKKEAPKPnSKEEKRRLKEE----RKKAKAEQRAREFEQRAR--EHQERDEKELEERRKAL 536
Cdd:pfam02029 277 LELEELKK-KREERRKLLEEeeqrRKQEEAERKLREEEEKRRmkEEIERRRAEAAEKRQKL 336
Caldesmon pfam02029
Caldesmon;
404-537 5.51e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 39.47  E-value: 5.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 404 SQKGEKGNAPIYLQERHKVKENKQPLEENKV-----------KPRNSGFE--EEEVKTRRSEPIKDQNNAIQQGETKNNE 470
Cdd:pfam02029 166 AEEVPTENFAKEEVKDEKIKKEKKVKYESKVfldqkrghpevKSQNGEEEvtKLKVTTKRRQGGLSQSQEREEEAEVFLE 245

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1492573121 471 SKNApvlKENATKKEAPKPNSKEEKRRLK--------EERKKAKAEQR-AREFEQRAREhQERDEKEL---EERRKALE 537
Cdd:pfam02029 246 AEQK---LEELRRRRQEKESEEFEKLRQKqqeaelelEELKKKREERRkLLEEEEQRRK-QEEAERKLreeEEKRRMKE 320
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 478-538 7.29e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 38.75  E-value: 7.29e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1492573121 478 KENATKKEAPKPNSKEEKRRLKEERKKAKAEQRAREFEQRAREHQE---RDEKELEERRKALEM 538
Cdd:pfam13868 278 QEEAEKRRMKRLEHRRELEKQIEEREEQRAAEREEELEEGERLREEeaeRRERIEEERQKKLKE 341
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 448-541 7.51e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 38.67  E-value: 7.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 448 TRRSEPIKDQNNAIQQGETKNNESKNAPVLKENATKKEAPKPNSKEEK--RRLKEERKKAKA--EQRAREFEQRAREHQE 523
Cdd:TIGR02794  24 YHSVKPEPGGGAEIIQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKklEQQAEEAEKQRAaeQARQKELEQRAAAEKA 103

                          90
                  ....*....|....*...
gi 1492573121 524 rdEKELEERRKALEMNKK 541
Cdd:TIGR02794 104 --AKQAEQAAKQAEEKQK 119
Caldesmon pfam02029
Caldesmon;
417-528 7.78e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 39.08  E-value: 7.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121 417 QERHKVKENKQPLEEnkVKPRNSGFEEEEVKTRRSepiKDQNNAIQQGETKNNESKNAPVLKENATKKEA----PKPNSK 492
Cdd:pfam02029 238 EEAEVFLEAEQKLEE--LRRRRQEKESEEFEKLRQ---KQQEAELELEELKKKREERRKLLEEEEQRRKQeeaeRKLREE 312

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1492573121 493 EEKRRLKEERKKAKAEqrAREFEQRAREHQERDEKE 528
Cdd:pfam02029 313 EEKRRMKEEIERRRAE--AAEKRQKLPEDSSSEGKK 346
PTZ00121 PTZ00121
MAEBL; Provisional
 401-541 9.23e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 9.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1492573121  401 FKPSQKGEKGNApiylQERHKVKENKQPLEEnkVKPRNSGFEEEEVKtRRSEPIKDQNNAIQQGETKNNESKNAPVLKEN 480
Cdd:PTZ00121  1100 AEEAKKTETGKA----EEARKAEEAKKKAED--ARKAEEARKAEDAR-KAEEARKAEDAKRVEIARKAEDARKAEEARKA 1172

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1492573121  481 ATKKEAPKPNSKEEKRRLKEERK--KAKAEQRAREFEQRAREHQER---DEKELEERRKALEMNKK 541
Cdd:PTZ00121  1173 EDAKKAEAARKAEEVRKAEELRKaeDARKAEAARKAEEERKAEEARkaeDAKKAEAVKKAEEAKKD 1238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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