NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1494899451|ref|WP_121638292|]
View 

MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Pseudoalteromonas]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-139 4.00e-29

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 103.51  E-value: 4.00e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899451   1 MSFEQLKLKNQLCHRLYMASNSIARAYREPLAALNLTYPQYVVMMALWEQDKITIAQLIDKTAIDGGAMTQILKKMTEKS 80
Cdd:COG1846     1 MSDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899451  81 LLAVIKDEHDKRKRLIQLTQSGQALKNEAADIPKNILCK-FESVDPTQAKQLMQLLDLVI 139
Cdd:COG1846    81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAElLAGLSEEELEALLRLLRRLA 140
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-139 4.00e-29

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 103.51  E-value: 4.00e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899451   1 MSFEQLKLKNQLCHRLYMASNSIARAYREPLAALNLTYPQYVVMMALWEQDKITIAQLIDKTAIDGGAMTQILKKMTEKS 80
Cdd:COG1846     1 MSDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899451  81 LLAVIKDEHDKRKRLIQLTQSGQALKNEAADIPKNILCK-FESVDPTQAKQLMQLLDLVI 139
Cdd:COG1846    81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAElLAGLSEEELEALLRLLRRLA 140
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
31-117 6.94e-18

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 73.78  E-value: 6.94e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899451   31 LAALNLTYPQYVVMMALWEQDKITIAQLIDKTAIDGGAMTQILKKMTEKSLLAVIKDEHDKRKRLIQLTQSGQALKNEAA 110
Cdd:smart00347   3 LKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLL 82


                   ....*..
gi 1494899451  111 DIPKNIL 117
Cdd:smart00347  83 EARSETL 89
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 34-92 4.08e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 49.89  E-value: 4.08e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1494899451  34 LNLTYPQYVVMMALWEQDKITIAQLIDKTAIDGGAMTQILKKMTEKSLLAVIKDEHDKR 92
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
16-105 2.73e-06

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 44.50  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899451  16 LYMASNSIARAYREPLAALNLTYPQYVVMMALWEQDKITIAQLIDKTAIDGGAMTQILKKMTEKSLLAVIKDEHDKRKRL 95
Cdd:PRK11512   18 IHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVL 97

                          90
                  ....*....|
gi 1494899451  96 IQLTQSGQAL 105
Cdd:PRK11512   98 VKLTTSGAAI 107
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
1-139 4.00e-29

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 103.51  E-value: 4.00e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899451   1 MSFEQLKLKNQLCHRLYMASNSIARAYREPLAALNLTYPQYVVMMALWEQDKITIAQLIDKTAIDGGAMTQILKKMTEKS 80
Cdd:COG1846     1 MSDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899451  81 LLAVIKDEHDKRKRLIQLTQSGQALKNEAADIPKNILCK-FESVDPTQAKQLMQLLDLVI 139
Cdd:COG1846    81 LVEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAElLAGLSEEELEALLRLLRRLA 140
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
31-117 6.94e-18

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 73.78  E-value: 6.94e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899451   31 LAALNLTYPQYVVMMALWEQDKITIAQLIDKTAIDGGAMTQILKKMTEKSLLAVIKDEHDKRKRLIQLTQSGQALKNEAA 110
Cdd:smart00347   3 LKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLL 82


                   ....*..
gi 1494899451  111 DIPKNIL 117
Cdd:smart00347  83 EARSETL 89
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 34-92 4.08e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 49.89  E-value: 4.08e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1494899451  34 LNLTYPQYVVMMALWEQDKITIAQLIDKTAIDGGAMTQILKKMTEKSLLAVIKDEHDKR 92
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-93 2.95e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 44.85  E-value: 2.95e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1494899451  36 LTYPQYVVMMALWEQDKITIAQLIDKTAIDGGAMTQILKKMTEKSLLAVIKDEHDKRK 93
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRRE 58
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
16-105 2.73e-06

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 44.50  E-value: 2.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899451  16 LYMASNSIARAYREPLAALNLTYPQYVVMMALWEQDKITIAQLIDKTAIDGGAMTQILKKMTEKSLLAVIKDEHDKRKRL 95
Cdd:PRK11512   18 IHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVL 97

                          90
                  ....*....|
gi 1494899451  96 IQLTQSGQAL 105
Cdd:PRK11512   98 VKLTTSGAAI 107
HTH_27 pfam13463
Winged helix DNA-binding domain;
36-102 3.65e-06

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 42.28  E-value: 3.65e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1494899451  36 LTYPQYVVMMAL-WEQDKITIAQLIDKTAIDGGAMTQILKKMTEKSLLAVIKDEHDKRKRLIQLTQSG 102
Cdd:pfam13463   1 LTRLEALILHNIgHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
PRK13777 PRK13777
HTH-type transcriptional regulator Hpr;
74-105 9.41e-03

HTH-type transcriptional regulator Hpr;


Pssm-ID: 237501  Cd Length: 185  Bit Score: 35.02  E-value: 9.41e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1494899451  74 KKMTEKSLLAVIKDEHDKRKRLIQLTQSGQAL 105
Cdd:PRK13777   81 KKLEERGYLTFSKKEDDKRNTYIELTEKGEEL 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH