|
Name |
Accession |
Description |
Interval |
E-value |
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
2-404 |
2.15e-52 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 179.66 E-value: 2.15e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 2 SKTKITLAIAASYFIFAILLNSVGTVILQAINTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVA 81
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 82 LVCLSTALISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEDanSHSSLLNTIEGIFMVGVLSGYWIFTAFIDPSQSNA 161
Cdd:COG0738 85 LGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE--TAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 162 WLNVYYALAALTLIVLLSVVIAPIAPAidKNKTDSSLSDFIAMLKLTYQPLVLIFIISAFLYVLIEQGVGTWLPTFNNQV 241
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSKLPEI--EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 242 LQLPVAISIQLASIFAAALAFGRLVAGQVLKHINWFFVLCGCLVAMALLIIITLPLTenlpntaitslfDAPLAAFVLPL 321
Cdd:COG0738 241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP------------GPWLALIGLAL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 322 IGFFMAPIYPVLNSVMLSALEKHqHAAMTGLIVVFSALGGTTGSMITGYVFEHFSGQHAFYLSLIPISLIFISVIIFKQR 401
Cdd:COG0738 309 VGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRK 387
|
...
gi 1494899464 402 TRA 404
Cdd:COG0738 388 RRK 390
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
11-397 |
1.95e-20 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 92.00 E-value: 1.95e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 11 AASYFIFAILLNSVGTVILQAINTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCLSTALI 90
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 91 SEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEdaNSHSSLLNTIEGIFMVGVLSGYWIFTAFIDpsQSNAWLNVYYALA 170
Cdd:cd17333 82 PSIYLFVVLMFLAGLGAGILDTGANTFVGALFE--ESSATRLNVLHGFFGLGALIGPLIATSLLT--SELSWSWAYLIIG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 171 ALTLIVLLSVVIAPIAPAIDKNKTDSSLSDFIA-MLKLTYQPLVLIFIISAFLYVLIEQGVGTWLPTFNNQVLQLPVAIS 249
Cdd:cd17333 158 LIYLLLAILILLTLFPELPSARNPQQSVGAFSAsASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 250 IQLASIFAAALAFGRLVAGQVLKHIN-WFFVLCGCLVAMALLIIITLpltenlpntaITSLFdapLAAFVLPLIGFFMAP 328
Cdd:cd17333 238 GYLLSGFWVGITIGRLLGGPISRRIKpHTLLVLSGSGALLGLLILLL----------APTLV---VGLVATALLGLFMAA 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1494899464 329 IYPVLNSVMLSALeKHQHAAMTGLIVVFSALGGTTGSMITGYVFEHFSGQHAFYLSLIPISLIFISVII 397
Cdd:cd17333 305 LFPTILSLGISNL-PYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
5-403 |
1.48e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 77.60 E-value: 1.48e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 5 KITLAIAASYFIFAILLNSVGTVILQAINTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVC 84
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 85 LSTALISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTeDANSHSSLLNTIEGIFMVGVLSGYWIFTAFIDpsqSNAWLN 164
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF-PPKERGRALGIFNAGGPLGGALAPPLLGWLLA---AFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 165 VYYALAALTLIVLLsvviapiapaidknktdsslsdfiamlkltyqPLVLIFIISAFLYVLIEQGVGTWLPTFNNQVLQL 244
Cdd:COG2271 166 AFLILGLPGLLLAL--------------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 245 PVAISIQLASIFAAALAFGRLVAG----QVLKHINWFFVLCGCLVAMALLIIITLPltenlpntaitslfDAPLAAFVLP 320
Cdd:COG2271 214 SLAQAGLLLSLPFLAGIVGSLLGGwlsdRLGRRRKLVLAIGLLLAALALLLLALLP--------------SPALAIALLF 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 321 LIGFFMAPIYPVLNSVMLSALEKHQHAAMTGLIVVFSALGGTTGSMITGYVFEHFSGQHAFYLSLIPISLIFISVIIFKQ 400
Cdd:COG2271 280 LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
...
gi 1494899464 401 RTR 403
Cdd:COG2271 360 ETR 362
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
14-398 |
1.75e-15 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 77.65 E-value: 1.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 14 YFIFAILLNSVGTVILQAINTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCL---STALI 90
Cdd:cd17394 8 FFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALlfiPAASL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 91 SEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEDANSHSSLlnTIEGIFM-VGVLSGYWIFTAFI--------------D 155
Cdd:cd17394 88 RTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRL--NLAQAFNsLGSTIAPLFGSYLIlsgipstatalaamS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 156 PSQSNA--------WLNVYYALAALTLIVLLSVVIAPIaPAIdKNKTDSSLSDFIAMLKLTYQPLVLIFIISAFLYVLIE 227
Cdd:cd17394 166 AAELQAyktaelasVQLPYLGIALVLLLLAVLILLSKL-PEI-EAAEAEALGSKGTLLRLLKNPHLRLGVLAIFFYVGAE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 228 QGVGTWLPTF-NNQVLQLPVAISIQLASIFAAALAFGRLVAGQVLKHINWFFVLCGCLVAMALLIIITLpltenlpntai 306
Cdd:cd17394 244 VAIWSFLINYlMEYIAGLTETSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLAVFALLGLLLLLGAI----------- 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 307 tsLFDAPLAAFVLPLIGFFMAPIYPVLNSVMLSALEKHQHAAMTGLIVvfSALGGTTGSMITGYVFEHFSGQHAFYLsli 386
Cdd:cd17394 313 --FTGGMVALYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVM--AIVGGAVVPLIQGAVADDAAGLRIAFL--- 385
|
410
....*....|..
gi 1494899464 387 pISLIFISVIIF 398
Cdd:cd17394 386 -VPLLCFAYILF 396
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
6-408 |
5.57e-12 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 66.83 E-value: 5.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 6 ITLAIAASYFIFAILLNSVGTVILQAINTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCL 85
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 86 STALISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEDANsHSSLLNTIEGIFMVGVLSGYWIFTAFIDpsqSNAWLNV 165
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR-RGLALGLAAGGGNLGAAVAAFLAPLLIA---AFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 166 YYALAALTLIV-LLSVVIAPIAPAIDKNKTDSSLSDFIAMLKltyQPLVLIFIISAFLYVLIEQGVGTWLPTFNNQVLQL 244
Cdd:COG2223 162 FLILGILLLVVaVLAWLFLRDPPAGAAAAAKASLRDQLEALR---DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 245 PVAISIQLASIFAAALAFGRLVAGQVLKHINWFFVLCGCLVAMALLIIITLPLTENLPntaitslfdapLAAFVLPLIGF 324
Cdd:COG2223 239 SAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLW-----------LFLVLFLLLGL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 325 FMAPIYPVLNSVMLSALEKHQHAAMTGLIVVFSALGGTTGSMITGYVFEHFSG-QHAFYLSLIPISLIFISVIIFKQRTR 403
Cdd:COG2223 308 ALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLTLLLYRRPR 387
|
....*
gi 1494899464 404 AISQH 408
Cdd:COG2223 388 RAAAA 392
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-362 |
1.78e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 65.00 E-value: 1.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 2 SKTKITLAIAASYFIFAILLNSVGTVILQAINTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVA 81
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 82 LVCLSTALISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEDANsHSSLLNTIEGIFMVGVLSGYWIFTAFIDpsqSNA 161
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPER-RGRALGLLGAGLGLGPALGPLLGGLLAD---LFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 162 WLNVYYALAALTLIVLLSVVIApiapaIDKNKTDSSLSDFIAMLKLTYQPLVLIFIISAFLYVLIEQGVGTWLPTFNNQV 241
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRL-----LPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 242 LQLPVAISIQLASIFAAALAFGRLVAGQVLKHINWFFVLCGCLVAMALLIIItlpltenlpntaITSLFDAPLAAFVLPL 321
Cdd:COG2814 238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL------------LALAGSLWLLLLALFL 305
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1494899464 322 IGFFMAPIYPVLNSVMLSALEKHQHAAMTGLIVVFSALGGT 362
Cdd:COG2814 306 LGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
10-396 |
4.42e-11 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 63.73 E-value: 4.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 10 IAASYFIFAILLNSVGTVILQAINTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCLSTAL 89
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 90 ISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEDANshsslLNTIEGIFMVGVLSGYWIFTAFIDPSQSNAWLnVYYAL 169
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNEN-----RGRVLGLYSTVLGLGFALGPLLLALVGTAGAL-PFLIA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 170 AALTLIVLLSVVIAPIAPAIDKNKTDSSLSDFIAMLKLTyqplvlifIISAFLYVLIEQGVGTWLPTFNNQvlqlpVAIS 249
Cdd:cd17477 155 AVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIAPLA--------LLGAFVAGFLEGAFYSLLPLYGLR-----LGLS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 250 IQLASIFAAALAFGRLVA----GQVLKHINWFFVLCGCLVAMALLIIItLPLTENLPNTAITSLFdaplaafvlpLIGFF 325
Cdd:cd17477 222 VAQAALLLAAFVLGGLLLqwplGWLADRFDRRRVLLGCALLGALAALL-LPLVPGLPLALLVLLF----------LWGGA 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1494899464 326 MAPIYPVLNSVMLSALEKHQHAAMTGLIVVFSALGGTTGSMITGYVFEHFsGQHAFYLSLIPISLIFISVI 396
Cdd:cd17477 291 AGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAF-GPHGLFLFLAAVALLFLLFL 360
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
10-393 |
5.58e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 60.52 E-value: 5.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 10 IAASYFIFAILLNSVGTVILQAINTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCLSTAL 89
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 90 ISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEDANShSSLLNTIEGIFMVGVLSGYWIFTAFIDPSQSNaWLNVYYAL 169
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERER-GRALGLLQAFGSVGGILGPLLGGILASSLGFG-WRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 170 AALTLIVLLSVVIAPIAPAID---KNKTDSSLSDFIAMLKLTYQPLVLIFIISAFLYVLIEQGVGTWLPTFNNQVLQLPV 246
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESaraKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 247 AISIQLASIFAAALAFGRLVAGQVLKHINWFFVLCGCLVAMALLIIITLPLtenlpntaitsLFDAPLAAFVLPLIGFFM 326
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLL-----------APSLLLLLLLLLLLGFGL 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1494899464 327 APIYPVLNSVMLSALEKHQHAAMTGLIVVFSALGGTTGSMITGYVFEHFSGQHAFYLSLIPISLIFI 393
Cdd:cd06174 308 GGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAA 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
10-365 |
1.77e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.97 E-value: 1.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 10 IAASYFIFAILLNSVGTVILQAI-NTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCLSTA 88
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 89 LISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEDANsHSSLLNTIEGIFMVGVLSGYWIFTAFIDpsqSNAWLNVYYA 168
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEE-RGRALGLVSAGFGLGAALGPLLGGLLAS---LFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 169 LAALTLIVLLSVVI-APIAPAIDKNKTDSSLSDFIAMLKLTYQPLVLIFIISAFLYVLIEQGVGTWLPTFnNQVLQLPVA 247
Cdd:pfam07690 157 LAILSLLAAVLLLLpRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 248 ISIQLASIFAAALAFGRLVAGQVLKHINWFFVLcgcLVAMALLIIITLPLtenlpnTAITSLFDAPLAAFVLPLIGFFMA 327
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL---LLALLLLILAALGL------LLLSLTLSSLWLLLALLLLGFGFG 306
|
330 340 350
....*....|....*....|....*....|....*...
gi 1494899464 328 PIYPVLNSVMLSALEKHQHAAMTGLIVVFSALGGTTGS 365
Cdd:pfam07690 307 LVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
10-399 |
6.15e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.20 E-value: 6.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 10 IAASYFIFAILLNSVGTVILQAINTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCLSTAL 89
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 90 ISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEDANShSSLLNTIEGIFMVGVLSGYWIFTAFIDPSQSNAwlnVYYAL 169
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEER-GRAMGIFSSAIGLGFLIGPLLGGLLADALGYRA---PFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 170 AALTLIVL-LSVVIAPIAPAIDKNKTDSSLSDFIAMLKLTYQPLVLIFIISAFLYVLIEQGVGTWLPTFNNQVLQLPVAI 248
Cdd:cd17325 157 AALALLALvLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 249 SIQLASIFAAALAFGRLVAGQVLKHINWFFVLCGCLVAMALLIIItLPLTENLpntaitslfdaPLAAFVLPLIGFFMAP 328
Cdd:cd17325 237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL-LPLATSF-----------WLLLLLLALLGLGLGL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1494899464 329 IYPVLNSVMLSALEKHQHAAMTGLIVVFSALGGTTGSMITGYVFEHFSGQHAFYLSLIPISLIFISVIIFK 399
Cdd:cd17325 305 VFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-402 |
9.60e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 56.81 E-value: 9.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 8 LAIAASYFIFAILLNSVGTVILQAINTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCLST 87
Cdd:COG2807 21 LAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLR 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 88 ALISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQvteDANSHSSLLNtieGIFMVGVLSGYWIFTAFIDP-SQSNAWLNVY 166
Cdd:COG2807 101 SLAPSVALLLAGTALIGAGIAVGNVLLPGLIKR---WFPDRVGLMT---GLYTAAMGLGAALAAGLTVPlAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 167 YALAALTLIVLLsvviaPIAPAIDKNKTDSSLSDFIAMLKLTY-QPLVLIFIISAFLYVLIEQGVGTWLPTFNNQvLQLP 245
Cdd:COG2807 175 AVWALLALLALL-----LWLPLLRRRPAAAAAAPAAASLRSLWrSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 246 VAISIQLASIFAAALAFGRLVAGQVLKHIN---WFFVLCGCLVAMALLIIITLPLTenlpntaitslfdapLAAFVLPLI 322
Cdd:COG2807 249 AATAGLLLSLFQLAGIPGSLLVPLLADRLGdrrPLLLLLGLLGLAGLLGLLLAPGS---------------LPWLWAVLL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 323 GFFMAPIYPVLNSVMLSALEKHQHAA-MTGLIVVFSALGGTTGSMITGYVFEHFSG-QHAFYLSLIPISLIFISVIIFKQ 400
Cdd:COG2807 314 GLGQGGLFPLALTLIGLRARTPAEAAaLSGMAQSVGYLLAALGPLLVGALHDATGSwTAALLLLAALAVLMLVAGLLAGR 393
|
..
gi 1494899464 401 RT 402
Cdd:COG2807 394 PY 395
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
8-398 |
6.21e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.11 E-value: 6.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 8 LAIAASYFIFAILLNSVGTVILQAI-NTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCLS 86
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIaEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 87 TALISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEDANSHSSLLNTIEGIFMVGVLS---GYWIFTAfidpsqsnAWL 163
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGpllGGLLAAI--------SWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 164 NVYYALAALTLIVLLSVVIAPIAPAidKNKTDSSLSDFIAMLKLTYQPLVLIFIISAFLYVLIEQGVGTWLPTFNNQVLQ 243
Cdd:cd17474 153 YPFFLLAALIPVAFLAILFLLPEPK--EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 244 LPVAISIQLASIFAAALAFGRLVAGQVLKH-INWFFVLCGCLVAMALLIIITLPLTenlpntaitslfDAPLAAFVLPLI 322
Cdd:cd17474 231 ISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVP------------SLALLLIAIVLF 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1494899464 323 GFFMAPIYPVLNSVMLSALEKHQHAAMTGLIVVFSALGGTTGSMITGYVFEHFsGQHAFYLSLIPISLIFISVIIF 398
Cdd:cd17474 299 GLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF-GLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
32-395 |
9.78e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 53.71 E-value: 9.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 32 INTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCLSTALISEFYMFKVLFAVIGCGFAVVK 111
Cdd:cd17478 23 IAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 112 VSVYSIIGQVTEDANShssllnTIEGIFMVGVLSGYWIFTAFIDPSQSNAWLNVYYALAALTLIVLLSVVIAPIAPAIDK 191
Cdd:cd17478 103 PEGARLASQAAGGRRG------LAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 192 NKTDSSLSDFIAMLKLTYQPLVLIFIIsAFLYVLIEQGVGTWLPTFNNQVLQLPVAISIqLASIFAAALAFGRLVAGQVL 271
Cdd:cd17478 177 AKKAAAKSSARSTLKGVWRALLLLLII-VFLRSWVLSSLTTFLPFYLVQRGYSLVFAGL-LLSLFLFAGAIGTLIGGPLS 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 272 KHINWFFVLCGCLVAMALLIIITLpltenlpntaitsLFDAPLAAFVLPLIGFFMAPIYPVLNSVMLSALEKHQhAAMTG 351
Cdd:cd17478 255 DRFGRRRVIIASLLLAAPFLLLFL-------------LTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNV-GLASG 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1494899464 352 LIVVFSALGGTTGSMITGYVFEHFSGQHAFY-LSLIPISLIFISV 395
Cdd:cd17478 321 LMMGLSFGLGGIGAPVLGALADAFGLESVLLiLALLPLLGALLAF 365
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
98-398 |
3.76e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.83 E-value: 3.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 98 VLFAVIGCGFAVVKVSVYSIIGQVTEDANSHSSLLNTIEGIFMVGVLSGYWIFTAFID---PSQSNAWLNVYYALAALTL 174
Cdd:COG2211 115 VTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAafgGDAALGYRLTALIFAVLGL 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 175 IVLLSVVIAPIAPAIDKNKTDSSLSDFIAMLKltyQPLVLIFIISAFLYVLIEQGVGTWLPTFNNQVLQLPVAISIQLAS 254
Cdd:COG2211 195 LAFLLTFFGTKERPVPEEEKVSLKESLKALLK---NRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLA 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 255 IFAAALAFGRLVAGQVLKHIN--WFFVLCGCLVAMALLIIITLPLTenlpntaitslfDAPLAAFVLPLIGFFMAPIYPV 332
Cdd:COG2211 272 LYFLAALLGAPLWPRLAKRFGkkKAFIIGLLLAALGLLLLFFLGPG------------NLWLLLVLAALAGIGLGAILVL 339
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1494899464 333 LNSVMLSALEKHQH-------AAMTGLIVVFSALGGTTGSMITGYVFEHF-----SGQHAFYLSLIPISLIFISVIIF 398
Cdd:COG2211 340 PWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFgyvagAAQSPSALTGIRLLFFLLPAVLL 417
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
7-396 |
1.57e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.86 E-value: 1.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 7 TLAIAASYFIFAILLNSVGtvilqaiNTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCLS 86
Cdd:cd17324 8 AFAIGTTEYVIQGLLPDIA-------RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 87 TALISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEDANSHSSLLNTIEGIFMVGVLSGywIFTAFIdpSQSNAWLNVY 166
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGR--PLGGLL--GQLLGWRAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 167 YALAALTLIVLLsvVIAPIAPAIdKNKTDSSLSDFIAMLKLTYQPLVLIFIISAFLYVLIEQGVGTWLPTFNNQVLQLPV 246
Cdd:cd17324 157 LAIAVLALLAAL--LLWRLLPSL-PPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 247 AISIQLASIFAAALAFGRLVAGQVLKHINWFFVLCGCLVAMALLIIITLpltenlpntaITSLFDAPLAAFVLPLIGFFM 326
Cdd:cd17324 234 SAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTL----------LGPSPLLLLVGLVLWGLGFFA 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 327 APiypVLNSVMLSALEKHQHAAMTGLIVVFSALGGTTGSMITGYVFEHFSGQHAFYLSLIPISLIFISVI 396
Cdd:cd17324 304 AH---SALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
6-396 |
1.17e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 6 ITLAIAASYFIFAILLnsvgTVILQAINTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCL 85
Cdd:cd17489 1 ILLANFFFFLSFYLLL----PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 86 STALISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEDAN-----SHSSLLNTIE-------GIFMVGVLSGYWIFTAF 153
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRrgegiGYYGLATTLAmalgpalGLFLYQHLGFAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 154 IdpsqsnawlnvyyALAALTLIVLLSVVIAPIAPAIDKNKTDSSLSDFIamlkltyQPLVLIFIISAFLYVLIEQGVGTW 233
Cdd:cd17489 157 A-------------VLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLV-------EKKVLPPALILFLASIAYGAISTF 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 234 LPTFNNQvlQLPVAISIQLaSIFAAALAFGRLVAGQVLKHINWFFVLCGCLVAMALLIIITlpltenlpnTAITSLFDAP 313
Cdd:cd17489 217 LPLYAAE--RGISNAGLFF-TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLL---------SFAGSPWMLL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 314 LAAFvlpLIGFFMAPIYPVLNSVMLSALEKHQHAAMTGLIVVFSALGGTTGSMITGYVFEHFSGQHAFYLSLIPISLIFI 393
Cdd:cd17489 285 LAAV---LYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
...
gi 1494899464 394 SVI 396
Cdd:cd17489 362 LYI 364
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
51-398 |
3.80e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.18 E-value: 3.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 51 LSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCLSTALISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEDANSHS- 129
Cdd:cd17320 45 LGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKi 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 130 -SLLNTIEGI-FMVGVLSGYWIFTAFidpsqsnAWLNVYYALAALTLIVLLSVVIAPIAPAIDKNKTDSSLSDFIAMLKL 207
Cdd:cd17320 125 fSLLMMILAIaPALAPLLGGLLLLFF-------GWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRV 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 208 TYQPLVLIFIISAFLYVLIEQGVGTWLPTFNNQVLQLPVAISIQLASIFAAALAFGRLVAGQVLKHI---NWFFVLCGCL 284
Cdd:cd17320 198 LKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFgprRLLRLGLLLL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 285 VAMALLIIITlpltenlpntaiTSLFDAPLAAFVLPLIGFF--MAPIYPVLNSVMLSALeKHQHAAMTGLIVVFSALGGT 362
Cdd:cd17320 278 LAAALVLLLA------------ALLGGLSLWPLVAPLFLIFfgFGLIFPNATSLALEPF-PHVAGTASALLGFLQFLIGA 344
|
330 340 350
....*....|....*....|....*....|....*.
gi 1494899464 363 TGSMITGYVfeHFSGQHAFYLSLIPISLIFISVIIF 398
Cdd:cd17320 345 LAGALVGLL--PNGTALPMGLLILVLGLLALLLLIL 378
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
2-412 |
5.77e-04 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 41.84 E-value: 5.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 2 SKTKITLAIAASYFIFAILLNSVGTVILQAINTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVA 81
Cdd:PRK03699 4 NRIKLTWISFLSYALTGALVIVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 82 LVCLSTALISEFYMFKVLFAVIG-CGFAVVKVSVYsIIGQVTEDANSHSSLLNTIEGIFMVGVLsgYWIFTAFIdPSQSN 160
Cdd:PRK03699 84 LAVAGLMFSHSLALFSIAMFVLGvVSGITMSIGTF-LITHVYEGKQRGSRLLFTDSFFSMAGMI--FPIIAAYL-LARSI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 161 AWLNVYYALAALTLIVLLSVVIAPIaPAIDKNKTDSSLSDFiamlKLTYQPLVLIFIISAFLYVLIEQGVGTWLPTFNNQ 240
Cdd:PRK03699 160 EWYWVYACIGLVYVAIFILTLFSEF-PALGKHAPKADKPVA----KEKWGIGVLFLAIAALLYILAQLTFISWVPEYAQK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 241 VLQLPVAISIQLASIFAAALAFGRLVAGQVLKHIN--WFFVLCGCLVAMALLIIITLPLTENLPNTAITslfdaplaafv 318
Cdd:PRK03699 235 KFGMSLEDAGNLVSNFWMAYMVGMWIFSFIVRFFDlqRILTVLAGLALVLMYLFVNTDDPSHLLYAILG----------- 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 319 lplIGFFMAPIYpvlNSVMLSALEKHQHAAMTglIVVFSALGGTTGSM----ITGYVFEHFSGQHAFYLSLIPISLIFIS 394
Cdd:PRK03699 304 ---LGFFSSAIY---TTIITLGSQQTKVASPK--LVNFILTCGTIGTMltfvVTSPIVAHFGLQAALLTANGLYAVVFVM 375
|
410
....*....|....*...
gi 1494899464 395 VIIFKQRTRAISQHAASI 412
Cdd:PRK03699 376 CILLGFVSKHRQHGALTA 393
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
35-398 |
1.21e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 40.63 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 35 LGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVALVCLSTALISEFYMFKVLFAVIGCGFAVVKVSV 114
Cdd:cd17319 33 LGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 115 YSII---------GQVTEDANSHSSLLNTIEGIFMVgvlsgyWIFTAFidpsqsnAWLNVYYALAALTLIvllsvviapi 185
Cdd:cd17319 113 IKALaewfparerGRATGLFNSGAPLGAAIGPPLSG------WLLLLF-------GWRWAFIIEGLLGLL---------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 186 apaidknktdsslsdfIAMLKLTYQPLVLIFIISAFLYVLIEQGVGTWLPTFNNQVLQLPVAISIQLASIFAAALAFGRL 265
Cdd:cd17319 170 ----------------LAVLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 266 VAGQVLKHINWF----FVLCGCLVAMALLIIITLpltenlpntaitsLFDAPLAAFVLPLIGFFMAPIYPVLNSVMLSAL 341
Cdd:cd17319 234 LGGRLSDRLLRGarrlVIIIGLLLAAVGLLLAYL-------------TTSPVVAVILLSLAGFGIGAASPVFWSLPADLL 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1494899464 342 EKHQHAAMTGLIVVFSALGGTTGSMITGYVFEHFSGQHAFYLSLIPISLIFISVIIF 398
Cdd:cd17319 301 PGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-177 |
7.39e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.37 E-value: 7.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 2 SKTKITLAIAASYFIFAILLNSVGTVILqAINTLGVSKTEASVLEGFKDLSIAIMSFVVASFIPRLGYKLAMLGALAVVA 81
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLL-AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1494899464 82 LVCLSTALISEFYMFKVLFAVIGCGFAVVKVSVYSIIGQVTEDANSH--SSLLNTIEGIFMVGVLSGYWIFTAFIDPSQS 159
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGrvFSVYNALNSGAMPLGALLAGLLADALGLSAV 365
|
170
....*....|....*...
gi 1494899464 160 NAWLNVYYALAALTLIVL 177
Cdd:cd06173 366 FLLAGALLLLAALLLLLL 383
|
|
| |
