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Conserved domains on  [gi|1501516773|ref|WP_122107273|]
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DNA-J related domain-containing protein [Pseudomonas sp. AOB-7]

Protein Classification

DNA-J related domain-containing protein( domain architecture ID 10574576)

DNA-J related domain-containing protein consists of an N-terminal DNA-J related domain and C-terminal J domain (also known as DnaJ domain); similar to molecular chaperone DnaJ, a protein that plays crucial roles in protein translation, folding, unfolding, translocation, and degradation, primarily by stimulating the ATPase activity of Hsp70

CATH:  1.10.287.110
Gene Ontology:  GO:0006457
PubMed:  35729039|9644977|8016869|15170475|9585179|10542335
SCOP:  4000605

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DNAJ_related pfam12339
DNA-J related protein; This domain family is found in bacteria, and is approximately 130 amino ...
 15-132 2.17e-56

DNA-J related protein; This domain family is found in bacteria, and is approximately 130 amino acids in length. The family is found in association with pfam00226. There is a conserved YYLD sequence motif. Mostof the sequences in this family are annotated as DNA-J related proteins but there is little publication to back this up.


:

Pssm-ID: 432489  Cd Length: 120  Bit Score: 173.94  E-value: 2.17e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1501516773  15 VLELLLAAPDGLAEYQLIQQLKQRHSGHIPNLPLTDKLVLFRTHFLLFNALYRLRERLWQEGRHLLQIAPLCIRLQP--Y 92
Cdd:pfam12339   1 LLELLRAHPEGIKEHTLIKELKERPYGLFPPLDLSPPLDLFRTHFLLFHALYRLQERLWPEGWGQLQIHALDIRLLPpaP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1501516773  93 QAGSAALSERDGLRDYYLDMSNLRDTDERDVERLLASFWT 132
Cdd:pfam12339  81 TSADAALDEADPLREYYLDWSNYEDTDEADVERLLDSFWT 120
DjlA COG1076
DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];
143-195 9.70e-08

DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440694 [Multi-domain]  Cd Length: 75  Bit Score: 47.48  E-value: 9.70e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1501516773 143 ALALFELDgpgAVLDLASIKRRYRQLVSQHHPDR---GGS-------TERLQSINKAMEILER 195
Cdd:COG1076     6 AFELLGLP---PDADDAELKRAYRKLQREHHPDRlaaGLPeeeqrlaLQKAAAINEAYETLKD 65
 
Name Accession Description Interval E-value
DNAJ_related pfam12339
DNA-J related protein; This domain family is found in bacteria, and is approximately 130 amino ...
 15-132 2.17e-56

DNA-J related protein; This domain family is found in bacteria, and is approximately 130 amino acids in length. The family is found in association with pfam00226. There is a conserved YYLD sequence motif. Mostof the sequences in this family are annotated as DNA-J related proteins but there is little publication to back this up.


Pssm-ID: 432489  Cd Length: 120  Bit Score: 173.94  E-value: 2.17e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1501516773  15 VLELLLAAPDGLAEYQLIQQLKQRHSGHIPNLPLTDKLVLFRTHFLLFNALYRLRERLWQEGRHLLQIAPLCIRLQP--Y 92
Cdd:pfam12339   1 LLELLRAHPEGIKEHTLIKELKERPYGLFPPLDLSPPLDLFRTHFLLFHALYRLQERLWPEGWGQLQIHALDIRLLPpaP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1501516773  93 QAGSAALSERDGLRDYYLDMSNLRDTDERDVERLLASFWT 132
Cdd:pfam12339  81 TSADAALDEADPLREYYLDWSNYEDTDEADVERLLDSFWT 120
DjlA COG1076
DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];
143-195 9.70e-08

DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440694 [Multi-domain]  Cd Length: 75  Bit Score: 47.48  E-value: 9.70e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1501516773 143 ALALFELDgpgAVLDLASIKRRYRQLVSQHHPDR---GGS-------TERLQSINKAMEILER 195
Cdd:COG1076     6 AFELLGLP---PDADDAELKRAYRKLQREHHPDRlaaGLPeeeqrlaLQKAAAINEAYETLKD 65
DnaJ smart00271
DnaJ molecular chaperone homology domain;
156-194 1.73e-07

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 46.46  E-value: 1.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1501516773  156 LDLASIKRRYRQLVSQHHPDRGGS-----TERLQSINKAMEILE 194
Cdd:smart00271  13 ASLDEIKKAYRKLALKYHPDKNPGdkeeaEEKFKEINEAYEVLS 56
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 158-193 1.74e-06

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 47.51  E-value: 1.74e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1501516773 158 LASIKRRYRQLVSQHHPDRGGSTERLQSINKAMEIL 193
Cdd:PTZ00037   42 TSEIKKAYRKLAIKHHPDKGGDPEKFKEISRAYEVL 77
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 157-195 4.69e-06

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 42.53  E-value: 4.69e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1501516773 157 DLASIKRRYRQLVSQHHPDRG----GSTERLQSINKAMEILER 195
Cdd:cd06257    13 SDEEIKKAYRKLALKYHPDKNpddpEAEEKFKEINEAYEVLSD 55
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 161-193 2.33e-05

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 40.53  E-value: 2.33e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1501516773 161 IKRRYRQLVSQHHPDRG----GSTERLQSINKAMEIL 193
Cdd:pfam00226  17 IKKAYRKLALKYHPDKNpgdpEAEEKFKEINEAYEVL 53
 
Name Accession Description Interval E-value
DNAJ_related pfam12339
DNA-J related protein; This domain family is found in bacteria, and is approximately 130 amino ...
 15-132 2.17e-56

DNA-J related protein; This domain family is found in bacteria, and is approximately 130 amino acids in length. The family is found in association with pfam00226. There is a conserved YYLD sequence motif. Mostof the sequences in this family are annotated as DNA-J related proteins but there is little publication to back this up.


Pssm-ID: 432489  Cd Length: 120  Bit Score: 173.94  E-value: 2.17e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1501516773  15 VLELLLAAPDGLAEYQLIQQLKQRHSGHIPNLPLTDKLVLFRTHFLLFNALYRLRERLWQEGRHLLQIAPLCIRLQP--Y 92
Cdd:pfam12339   1 LLELLRAHPEGIKEHTLIKELKERPYGLFPPLDLSPPLDLFRTHFLLFHALYRLQERLWPEGWGQLQIHALDIRLLPpaP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1501516773  93 QAGSAALSERDGLRDYYLDMSNLRDTDERDVERLLASFWT 132
Cdd:pfam12339  81 TSADAALDEADPLREYYLDWSNYEDTDEADVERLLDSFWT 120
DjlA COG1076
DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];
143-195 9.70e-08

DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440694 [Multi-domain]  Cd Length: 75  Bit Score: 47.48  E-value: 9.70e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1501516773 143 ALALFELDgpgAVLDLASIKRRYRQLVSQHHPDR---GGS-------TERLQSINKAMEILER 195
Cdd:COG1076     6 AFELLGLP---PDADDAELKRAYRKLQREHHPDRlaaGLPeeeqrlaLQKAAAINEAYETLKD 65
DnaJ smart00271
DnaJ molecular chaperone homology domain;
156-194 1.73e-07

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 46.46  E-value: 1.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1501516773  156 LDLASIKRRYRQLVSQHHPDRGGS-----TERLQSINKAMEILE 194
Cdd:smart00271  13 ASLDEIKKAYRKLALKYHPDKNPGdkeeaEEKFKEINEAYEVLS 56
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 158-193 1.74e-06

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 47.51  E-value: 1.74e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1501516773 158 LASIKRRYRQLVSQHHPDRGGSTERLQSINKAMEIL 193
Cdd:PTZ00037   42 TSEIKKAYRKLAIKHHPDKGGDPEKFKEISRAYEVL 77
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 157-195 4.69e-06

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 42.53  E-value: 4.69e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1501516773 157 DLASIKRRYRQLVSQHHPDRG----GSTERLQSINKAMEILER 195
Cdd:cd06257    13 SDEEIKKAYRKLALKYHPDKNpddpEAEEKFKEINEAYEVLSD 55
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
152-193 1.50e-05

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 42.01  E-value: 1.50e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1501516773 152 PGAvlDLASIKRRYRQLVSQHHPDRGG-----STERLQSINKAMEIL 193
Cdd:COG2214    15 PDA--SLEEIRQAYRRLAKLLHPDRGGelkalAEELFQRLNEAYEVL 59
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 161-193 2.33e-05

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 40.53  E-value: 2.33e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1501516773 161 IKRRYRQLVSQHHPDRG----GSTERLQSINKAMEIL 193
Cdd:pfam00226  17 IKKAYRKLALKYHPDKNpgdpEAEEKFKEINEAYEVL 53
PRK14293 PRK14293
molecular chaperone DnaJ;
160-193 4.95e-05

molecular chaperone DnaJ;


Pssm-ID: 237663 [Multi-domain]  Cd Length: 374  Bit Score: 43.05  E-value: 4.95e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1501516773 160 SIKRRYRQLVSQHHPD---RGGSTERLQSINKAMEIL 193
Cdd:PRK14293   19 ELKRAYRRLARKYHPDvnkEPGAEDRFKEINRAYEVL 55
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 157-193 7.03e-05

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 41.23  E-value: 7.03e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1501516773 157 DLASIKRRYRQLVSQHHPDRGGS----TERLQSINKAMEIL 193
Cdd:COG0484    13 SAEEIKKAYRKLAKKYHPDRNPGdpeaEEKFKEINEAYEVL 53
PHA03102 PHA03102
Small T antigen; Reviewed
 138-196 9.43e-05

Small T antigen; Reviewed


Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 40.81  E-value: 9.43e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1501516773 138 EEKQAALALFELDgPGAVLDLASIKRRYRQLVSQHHPDRGGSTERLQSINKAMEILERY 196
Cdd:PHA03102    2 EESKELMDLLGLP-RSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRES 59
PTZ00100 PTZ00100
DnaJ chaperone protein; Provisional
 161-193 3.56e-03

DnaJ chaperone protein; Provisional


Pssm-ID: 240265  Cd Length: 116  Bit Score: 35.98  E-value: 3.56e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1501516773 161 IKRRYRQLVSQHHPDRGGSTERLQSINKAMEIL 193
Cdd:PTZ00100   82 IREAHKQLMLRNHPDNGGSTYIASKVNEAKDLL 114
PRK14292 PRK14292
chaperone protein DnaJ; Provisional
 147-193 4.34e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 237662 [Multi-domain]  Cd Length: 371  Bit Score: 37.18  E-value: 4.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1501516773 147 FELDGPGAVLDLASIKRRYRQLVSQHHPDRG---GSTERLQSINKAMEIL 193
Cdd:PRK14292    5 YELLGVSRTASADEIKSAYRKLALKYHPDRNkekGAAEKFAQINEAYAVL 54
PHA02624 PHA02624
large T antigen; Provisional
 138-196 5.05e-03

large T antigen; Provisional


Pssm-ID: 222912 [Multi-domain]  Cd Length: 647  Bit Score: 37.27  E-value: 5.05e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1501516773 138 EEKQAALALFELDgPGAVLDLASIKRRYRQLVSQHHPDRGGSTERLQSINKAMEILERY 196
Cdd:PHA02624    8 EESKELMDLLGLP-MAAWGNLPLMRKAYLRKCKEYHPDKGGDEEKMKRLNSLYKKLQEG 65
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
 161-193 5.16e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 37.05  E-value: 5.16e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1501516773 161 IKRRYRQLVSQHHPDR----GGSTERLQSINKAMEIL 193
Cdd:PRK10767   21 IKKAYRKLAMKYHPDRnpgdKEAEEKFKEIKEAYEVL 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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