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Conserved domains on  [gi|1502194035|ref|WP_122202871|]
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shikimate kinase [Parabacteroides merdae]

Protein Classification

nucleoside/nucleotide kinase family protein( domain architecture ID 106737)

nucleoside/nucleotide kinase family protein may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 1-169 2.94e-97

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member PRK13949:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 169  Bit Score: 278.15  E-value: 2.94e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   1 MKRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGG 80
Cdd:PRK13949    1 MARIFLVGYMGAGKTTLGKALARELGLSFIDLDFFIENRFHKTVGDIFAERGEAVFRELERNMLHEVAEFEDVVISTGGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  81 APCFFDNMEFMNGAGQTVYLKVSVEELAKRLELCKSTRPILKGRSGDELKAFIAESLEKREPFYSKASIVFDAEEMMTDQ 160
Cdd:PRK13949   81 APCFFDNMELMNASGTTVYLKVSPEVLFVRLRLAKQQRPLLKGKSDEELLDFIIEALEKRAPFYRQAKIIFNADKLEDES 160


                  ....*....
gi 1502194035 161 DVYNISQEL 169
Cdd:PRK13949  161 QIEQLVQRL 169
 
Name Accession Description Interval E-value
PRK13949 PRK13949
shikimate kinase; Provisional
 1-169 2.94e-97

shikimate kinase; Provisional


Pssm-ID: 140006 [Multi-domain]  Cd Length: 169  Bit Score: 278.15  E-value: 2.94e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   1 MKRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGG 80
Cdd:PRK13949    1 MARIFLVGYMGAGKTTLGKALARELGLSFIDLDFFIENRFHKTVGDIFAERGEAVFRELERNMLHEVAEFEDVVISTGGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  81 APCFFDNMEFMNGAGQTVYLKVSVEELAKRLELCKSTRPILKGRSGDELKAFIAESLEKREPFYSKASIVFDAEEMMTDQ 160
Cdd:PRK13949   81 APCFFDNMELMNASGTTVYLKVSPEVLFVRLRLAKQQRPLLKGKSDEELLDFIIEALEKRAPFYRQAKIIFNADKLEDES 160


                  ....*....
gi 1502194035 161 DVYNISQEL 169
Cdd:PRK13949  161 QIEQLVQRL 169
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 4-170 1.13e-64

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 195.73  E-value: 1.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   4 IFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGGAPC 83
Cdd:COG0703     1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLEEENAVIATGGGAVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  84 FFDNMEFMNGAGQTVYLKVSVEELAKRLELcKSTRPILKgrsGDELKAFIAESLEKREPFYSK-ASIVFDAEEMMTDQDV 162
Cdd:COG0703    81 SPENRELLKEHGTVVYLDASPETLLERLRR-DDNRPLLQ---GEDPRERLEELLAEREPLYREvADITVDTDGRSPEEVV 156


                  ....*...
gi 1502194035 163 YNISQELA 170
Cdd:COG0703   157 DEILEALE 164
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 3-160 2.51e-56

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 173.90  E-value: 2.51e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   3 RIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGGAP 82
Cdd:cd00464     1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLLLTKENAVIATGGGAV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1502194035  83 CFFDNMEFMNGAGQTVYLKVSVEELAKRLELcKSTRPILKGRSGDELKAFiaesLEKREPFYSK-ASIVFDAEEMMTDQ 160
Cdd:cd00464    81 LREENRRLLLENGIVVWLDASPEELLERLAR-DKTRPLLQDEDPERLREL----LEEREPLYREvADLTIDTDELSPEE 154
SKI pfam01202
Shikimate kinase;
10-170 4.08e-49

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 155.82  E-value: 4.08e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  10 MGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGGAPCFFDNME 89
Cdd:pfam01202   1 MGAGKSTIGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAEHGLVIATGGGAVLSEENRD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  90 FMNGAGQTVYLKVSVEELAKRLELCKsTRPILKGRSGDELKafIAESLEKREPFYSKAS-IVFDAEEMMTDQDVYNISQE 168
Cdd:pfam01202  81 LLKERGIVIYLDAPLEVLLERLKRDK-TRPLLQNKDPEEEL--LELLFEERDPLYEEAAdIVIDTDESSPEEVATEILEA 157


                  ..
gi 1502194035 169 LA 170
Cdd:pfam01202 158 LE 159
 
Name Accession Description Interval E-value
PRK13949 PRK13949
shikimate kinase; Provisional
 1-169 2.94e-97

shikimate kinase; Provisional


Pssm-ID: 140006 [Multi-domain]  Cd Length: 169  Bit Score: 278.15  E-value: 2.94e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   1 MKRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGG 80
Cdd:PRK13949    1 MARIFLVGYMGAGKTTLGKALARELGLSFIDLDFFIENRFHKTVGDIFAERGEAVFRELERNMLHEVAEFEDVVISTGGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  81 APCFFDNMEFMNGAGQTVYLKVSVEELAKRLELCKSTRPILKGRSGDELKAFIAESLEKREPFYSKASIVFDAEEMMTDQ 160
Cdd:PRK13949   81 APCFFDNMELMNASGTTVYLKVSPEVLFVRLRLAKQQRPLLKGKSDEELLDFIIEALEKRAPFYRQAKIIFNADKLEDES 160


                  ....*....
gi 1502194035 161 DVYNISQEL 169
Cdd:PRK13949  161 QIEQLVQRL 169
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 4-170 1.13e-64

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 195.73  E-value: 1.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   4 IFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGGAPC 83
Cdd:COG0703     1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDTDAEIEERAGMSIPEIFAEEGEAGFRELEREVLAELLEEENAVIATGGGAVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  84 FFDNMEFMNGAGQTVYLKVSVEELAKRLELcKSTRPILKgrsGDELKAFIAESLEKREPFYSK-ASIVFDAEEMMTDQDV 162
Cdd:COG0703    81 SPENRELLKEHGTVVYLDASPETLLERLRR-DDNRPLLQ---GEDPRERLEELLAEREPLYREvADITVDTDGRSPEEVV 156


                  ....*...
gi 1502194035 163 YNISQELA 170
Cdd:COG0703   157 DEILEALE 164
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 3-160 2.51e-56

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 173.90  E-value: 2.51e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   3 RIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGGAP 82
Cdd:cd00464     1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLDELIEQRAGMSIPEIFAEEGEEGFRELEREVLLLLLTKENAVIATGGGAV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1502194035  83 CFFDNMEFMNGAGQTVYLKVSVEELAKRLELcKSTRPILKGRSGDELKAFiaesLEKREPFYSK-ASIVFDAEEMMTDQ 160
Cdd:cd00464    81 LREENRRLLLENGIVVWLDASPEELLERLAR-DKTRPLLQDEDPERLREL----LEEREPLYREvADLTIDTDELSPEE 154
aroK PRK00131
shikimate kinase; Reviewed
 1-155 4.13e-53

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 166.52  E-value: 4.13e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   1 MKRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGG 80
Cdd:PRK00131    4 GPNIVLIGFMGAGKSTIGRLLAKRLGYDFIDTDHLIEARAGKSIPEIFEEEGEAAFRELEEEVLAELLARHNLVISTGGG 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1502194035  81 APCFFDNMEFMNGAGQTVYLKVSVEELAKRLELcKSTRPILK-GRSGDELKAFiaesLEKREPFYSK-ASIVFDAEE 155
Cdd:PRK00131   84 AVLREENRALLRERGTVVYLDASFEELLRRLRR-DRNRPLLQtNDPKEKLRDL----YEERDPLYEEvADITVETDG 155
SKI pfam01202
Shikimate kinase;
10-170 4.08e-49

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 155.82  E-value: 4.08e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  10 MGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGGAPCFFDNME 89
Cdd:pfam01202   1 MGAGKSTIGRLLAKALGLPFIDTDEEIEKRTGMSIAEIFEEEGEEGFRRLESEVLKELLAEHGLVIATGGGAVLSEENRD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  90 FMNGAGQTVYLKVSVEELAKRLELCKsTRPILKGRSGDELKafIAESLEKREPFYSKAS-IVFDAEEMMTDQDVYNISQE 168
Cdd:pfam01202  81 LLKERGIVIYLDAPLEVLLERLKRDK-TRPLLQNKDPEEEL--LELLFEERDPLYEEAAdIVIDTDESSPEEVATEILEA 157


                  ..
gi 1502194035 169 LA 170
Cdd:pfam01202 158 LE 159
aroL PRK03731
shikimate kinase AroL;
1-153 4.32e-35

shikimate kinase AroL;


Pssm-ID: 235153 [Multi-domain]  Cd Length: 171  Bit Score: 120.43  E-value: 4.32e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   1 MKRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAfEDVLVSTGGG 80
Cdd:PRK03731    2 TQPLFLVGARGCGKTTVGMALAQALGYRFVDTDQWLQSTSNMTVAEIVEREGWAGFRARESAALEAVTA-PSTVIATGGG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1502194035  81 APCFFDNMEFMNGAGQTVYLKVSVEELAKRLELC--KSTRPILKGRSgdeLKAFIAESLEKREPFYSK-ASIVFDA 153
Cdd:PRK03731   81 IILTEENRHFMRNNGIVIYLCAPVSVLANRLEANpeEDQRPTLTGKP---ISEEVAEVLAEREALYREvAHHIIDA 153
PRK13947 PRK13947
shikimate kinase; Provisional
 1-168 8.20e-31

shikimate kinase; Provisional


Pssm-ID: 184412 [Multi-domain]  Cd Length: 171  Bit Score: 109.80  E-value: 8.20e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   1 MKRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGG 80
Cdd:PRK13947    1 MKNIVLIGFMGTGKTTVGKRVATTLSFGFIDTDKEIEKMTGMTVAEIFEKDGEVRFRSEEKLLVKKLARLKNLVIATGGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  81 APCFFDNMEFMNGAGQTVYLKVSVEELAKRLELCKStRPILkgrSGDELKAFIAESLEKREPFYSKASIVFDAEEMMTDQ 160
Cdd:PRK13947   81 VVLNPENVVQLRKNGVVICLKARPEVILRRVGKKKS-RPLL---MVGDPEERIKELLKEREPFYDFADYTIDTGDMTIDE 156


                  ....*...
gi 1502194035 161 DVYNISQE 168
Cdd:PRK13947  157 VAEEIIKA 164
PRK13946 PRK13946
shikimate kinase; Provisional
 2-150 1.18e-30

shikimate kinase; Provisional


Pssm-ID: 184411 [Multi-domain]  Cd Length: 184  Bit Score: 109.63  E-value: 1.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   2 KRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGGA 81
Cdd:PRK13946   11 RTVVLVGLMGAGKSTVGRRLATMLGLPFLDADTEIERAARMTIAEIFAAYGEPEFRDLERRVIARLLKGGPLVLATGGGA 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1502194035  82 PCFFDNMEFMNGAGQTVYLKVSVEELAKRLELcKSTRPILKgrsGDELKAFIAESLEKREPFYSKASIV 150
Cdd:PRK13946   91 FMNEETRAAIAEKGISVWLKADLDVLWERVSR-RDTRPLLR---TADPKETLARLMEERYPVYAEADLT 155
aroK PRK05057
shikimate kinase AroK;
2-169 6.97e-27

shikimate kinase AroK;


Pssm-ID: 235335 [Multi-domain]  Cd Length: 172  Bit Score: 99.79  E-value: 6.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   2 KRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGGA 81
Cdd:PRK05057    5 RNIFLVGPMGAGKSTIGRQLAQQLNMEFYDSDQEIEKRTGADIGWVFDVEGEEGFRDREEKVINELTEKQGIVLATGGGS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  82 PCFFDNMEFMNGAGQTVYLKVSVEELAKRLELCKStRPILKgrsGDELKAFIAESLEKREPFYSK-ASIVFDAEEMMTDQ 160
Cdd:PRK05057   85 VKSRETRNRLSARGVVVYLETTIEKQLARTQRDKK-RPLLQ---VDDPREVLEALANERNPLYEEiADVTIRTDDQSAKV 160


                  ....*....
gi 1502194035 161 DVYNISQEL 169
Cdd:PRK05057  161 VANQIIHML 169
PRK13948 PRK13948
shikimate kinase; Provisional
 6-149 5.52e-26

shikimate kinase; Provisional


Pssm-ID: 184413 [Multi-domain]  Cd Length: 182  Bit Score: 97.55  E-value: 5.52e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   6 LIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGGAPCFF 85
Cdd:PRK13948   15 LAGFMGTGKSRIGWELSRALMLHFIDTDRYIERVTGKSIPEIFRHLGEAYFRRCEAEVVRRLTRLDYAVISLGGGTFMHE 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1502194035  86 DNMEFMNGAGQTVYLKVSVEELAKRLElcKSTRPILKgrSGDELKAfIAESLEKREPFYSKASI 149
Cdd:PRK13948   95 ENRRKLLSRGPVVVLWASPETIYERTR--PGDRPLLQ--VEDPLGR-IRTLLNEREPVYRQATI 153
PLN02199 PLN02199
shikimate kinase
 2-156 3.54e-25

shikimate kinase


Pssm-ID: 177850 [Multi-domain]  Cd Length: 303  Bit Score: 98.23  E-value: 3.54e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   2 KRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKT-VGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGG 80
Cdd:PLN02199  103 RSMYLVGMMGSGKTTVGKLMSKVLGYTFFDCDTLIEQAMNGTsVAEIFVHHGENFFRGKETDALKKLSSRYQVVVSTGGG 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  81 APCFFDNMEFMNgAGQTVYLKVSVEELAKRLELCKS-TRPILKGRSGDELKAF---IAESLEKREPFYSKASIVFDAEEM 156
Cdd:PLN02199  183 AVIRPINWKYMH-KGISIWLDVPLEALAHRIAAVGTdSRPLLHDESGDAYSVAfkrLSAIWDERGEAYTNANARVSLENI 261
PRK13951 PRK13951
bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;
3-146 1.65e-23

bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;


Pssm-ID: 172457 [Multi-domain]  Cd Length: 488  Bit Score: 95.74  E-value: 1.65e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   3 RIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGGAP 82
Cdd:PRK13951    2 RIFLVGMMGSGKSTIGKRVSEVLDLQFIDMDEEIERREGRSVRRIFEEDGEEYFRLKEKELLRELVERDNVVVATGGGVV 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1502194035  83 CFFDNMEFMNGAgQTVYLKVSVEELAKRLELckSTRPILKgrsgdELKAFIAESLEKREPFYSK 146
Cdd:PRK13951   82 IDPENRELLKKE-KTLFLYAPPEVLMERVTT--ENRPLLR-----EGKERIREIWERRKQFYTE 137
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 2-152 2.32e-21

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 88.09  E-value: 2.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   2 KRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLRE-VAAFEDVLVSTGGG 80
Cdd:PRK08154  134 RRIALIGLRGAGKSTLGRMLAARLGVPFVELNREIEREAGLSVSEIFALYGQEGYRRLERRALERlIAEHEEMVLATGGG 213

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1502194035  81 ---APCFFDnmeFMNGAGQTVYLKVSVEELAKRLELCKSTRPILKGRSG-DELKAFiaesLEKREPFYSKASIVFD 152
Cdd:PRK08154  214 ivsEPATFD---LLLSHCYTVWLKASPEEHMARVRAQGDLRPMADNREAmEDLRRI----LASREPLYARADAVVD 282
PRK14021 PRK14021
bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional
 6-150 2.39e-18

bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional


Pssm-ID: 184458 [Multi-domain]  Cd Length: 542  Bit Score: 81.06  E-value: 2.39e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   6 LIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREVAAFEDVLVSTGGGAPCFF 85
Cdd:PRK14021   11 IIGMMGAGKTRVGKEVAQMMRLPFADADVEIEREIGMSIPSYFEEYGEPAFREVEADVVADMLEDFDGIFSLGGGAPMTP 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1502194035  86 DNM----EFMNGAGQTVYLKVSVEELAKRLELcKSTRPILKGRSGDELKafiaESLEKREPFYSKASIV 150
Cdd:PRK14021   91 STQhalaSYIAHGGRVVYLDADPKEAMERANR-GGGRPMLNGDANKRWK----KLFKQRDPVFRQVANV 154
PRK00625 PRK00625
shikimate kinase; Provisional
 2-112 1.31e-13

shikimate kinase; Provisional


Pssm-ID: 134335 [Multi-domain]  Cd Length: 173  Bit Score: 65.16  E-value: 1.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   2 KRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTV----GQLFAEKGEDAFRDIERRMLREVAAfEDVLVST 77
Cdd:PRK00625    1 MQIFLCGLPTVGKTSFGKALAKFLSLPFFDTDDLIVSNYHGALysspKEIYQAYGEEGFCREEFLALTSLPV-IPSIVAL 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1502194035  78 GGGAPCFFDNMEFMNGAGQTVYLKVSVEELAKRLE 112
Cdd:PRK00625   80 GGGTLMIEPSYAHIRNRGLLVLLSLPIATIYQRLQ 114
AAA_18 pfam13238
AAA domain;
4-112 7.32e-09

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 51.28  E-value: 7.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   4 IFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYIEGRYHKTVGQLFAEKGE--DAFRDIERRMLREVAAFE--DVLVSTGG 79
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPETRESKRldEDKLDRLLDLLEENAALEegGNLIIDGH 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1502194035  80 GAPCFFDNMEFMNGagqtVYLKVSVEELAKRLE 112
Cdd:pfam13238  81 LAELEPERAKDLVG----IVLRASPEELLERLE 109
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 4-111 2.24e-05

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 42.30  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   4 IFLIGYMGAGKTTVGKVLSRQLGLSFIDLD-----HYIEGRYHKTVGQLFAEKGEDAFRDIERRMLREvaafedvlvstg 78
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSSDderkrLFGEGRPSISYYTDATDRTYERLHELARIALRA------------ 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1502194035  79 gGAPCFFDN--------MEFMNGAGQT------VYLKVSVEELAKRL 111
Cdd:pfam13671  70 -GRPVILDAtnlrrderARLLALAREYgvpvriVVFEAPEEVLRERL 115
GntK COG3265
Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the ...
 1-35 4.73e-05

Gluconate kinase [Carbohydrate transport and metabolism]; Gluconate kinase is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442496 [Multi-domain]  Cd Length: 164  Bit Score: 41.65  E-value: 4.73e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1502194035   1 MKRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHY 35
Cdd:COG3265     1 PMVIVVMGVSGSGKSTVGQALAERLGWPFIDGDDF 35
PRK08118 PRK08118
DNA topology modulation protein;
1-33 4.75e-05

DNA topology modulation protein;


Pssm-ID: 181235  Cd Length: 167  Bit Score: 41.52  E-value: 4.75e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1502194035   1 MKRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLD 33
Cdd:PRK08118    1 MKKIILIGSGGSGKSTLARQLGEKLNIPVHHLD 33
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
10-144 1.07e-04

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 40.96  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  10 MGAGKTTVGKVLSRQLGLSFID------------LDHYIEGRYHKTVGQLFAEKG--EDAFRDIERRMLREVAAFEDVLV 75
Cdd:COG1102     9 PGSGGTTIAKRLAEKLGLPLYDgeilreaakergLSEEEFEKLDEKAPSLLYRDTaeEDEIDRALDKVIRELARKGNCVI 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1502194035  76 sTGGGAPCFFDNMEfmngAGQTVYLKVSVEELAKRLelckSTRpilKGRSGDELKAFIAESLEKREPFY 144
Cdd:COG1102    89 -VGRLADWILRDRP----NVLKVFLTAPLEVRVKRI----AER---EGISEEEAEKEIKKRDKSRAKYY 145
PRK06217 PRK06217
hypothetical protein; Validated
 1-36 3.87e-04

hypothetical protein; Validated


Pssm-ID: 168472  Cd Length: 183  Bit Score: 39.26  E-value: 3.87e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1502194035   1 MKRIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHYI 36
Cdd:PRK06217    1 MMRIHITGASGSGTTTLGAALAERLDIPHLDTDDYF 36
EutP COG4917
Ethanolamine utilization protein EutP, contains a P-loop NTPase domain [Amino acid transport ...
 1-43 7.84e-04

Ethanolamine utilization protein EutP, contains a P-loop NTPase domain [Amino acid transport and metabolism];


Pssm-ID: 443945 [Multi-domain]  Cd Length: 145  Bit Score: 37.86  E-value: 7.84e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1502194035   1 MKRIFLIGYMGAGKTTvgkvLSRQLglsfidldHYIEGRYHKT 43
Cdd:COG4917     1 MKRIMLIGRSGAGKTT----LTQAL--------NGEELEYRKT 31
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
4-112 1.17e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 37.59  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035   4 IFLIGYMGAGKTTVGKVLSRQLGLSFIDLDHyIEGRYHKtvGQLFAEKGEDAFRDIERRMLREVAAF-----EDVLVSTG 78
Cdd:COG0645     2 ILVCGLPGSGKSTLARALAERLGAVRLRSDV-VRKRLFG--AGLAPLERSPEATARTYARLLALAREllaagRSVILDAT 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1502194035  79 GGAPcfFDNMEFMNGAGQT------VYLKVSVEELAKRLE 112
Cdd:COG0645    79 FLRR--AQREAFRALAEEAgapfvlIWLDAPEEVLRERLE 116
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 11-141 1.73e-03

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 37.08  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1502194035  11 GAGKTTVGKVLSRQLGLSFID---LDHYIEGRYHKTVGQLFaekgedAFRDIERRMLREVAAFEDVLvstgggapcffdn 87
Cdd:cd02020     9 GSGKSTVAKLLAKKLGLPYLDtggIRTEEVGKLASEVAAIP------EVRKALDERQRELAKKPGIV------------- 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1502194035  88 ME-------FMNGAGQTVYLKVSVEELAKRlelcKSTRPILKGRSGDelKAFIAESLEKRE 141
Cdd:cd02020    70 LEgrdigtvVFPDADLKIFLTASPEVRAKR----RAKQLQAKGEGVD--LEEILAEIIERD 124
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 4-33 2.11e-03

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 36.85  E-value: 2.11e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1502194035   4 IFLIGYMGAGKTTVGKVLSRQLGLSFIDLD 33
Cdd:cd02021     2 IVVMGVSGSGKSTVGKALAERLGAPFIDGD 31
CoaE COG0237
Dephospho-CoA kinase [Coenzyme transport and metabolism]; Dephospho-CoA kinase is part of the ...
 1-72 2.99e-03

Dephospho-CoA kinase [Coenzyme transport and metabolism]; Dephospho-CoA kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440007  Cd Length: 193  Bit Score: 36.58  E-value: 2.99e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1502194035   1 MKRIFLIGYMGAGKTTVGKVLsRQLGLSFIDLD---HYIEGRYHKTVGQLFAEKGEDAFRD---IERRMLREVaAFED 72
Cdd:COG0237     1 MLIIGLTGGIGSGKSTVARMF-AELGAPVIDADaiaRELVEPGGPALAAIVEAFGEEILDAdgsLDRKALAEI-VFAD 76
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 3-34 7.35e-03

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 33.85  E-value: 7.35e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1502194035   3 RIFLIGYMGAGKTTVGKVLSRQLGLSFIDLDH 34
Cdd:cd02019     1 IIAITGGSGSGKSTVAKKLAEQLGGRSVVVLD 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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