|
Name |
Accession |
Description |
Interval |
E-value |
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
218-440 |
2.71e-38 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 138.89 E-value: 2.71e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 218 LEQQKQENLKLEQMKVEFLRGASHELKTPLASLKIILENMRDKIGRYK-DRDRYLAVSLDIVDEMNQIVLEILSLSSVQ- 295
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPeERRELLEIIRESAERLLRLIEDLLDLSRLEs 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 296 -ELAGDKEWIQLDQVLEQILDQYKVLAQSRALTIDNQIPDKA--VYMDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEE 372
Cdd:COG2205 82 gKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELplVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1514708724 373 GTH--LAVENT----SQEMVE-IAEMPMTASRQKKEG--GLGLFVVQHLLD-HE-ELAYQfDKTAMGLRFRMELPKDPQ 440
Cdd:COG2205 162 GDGvrISVSDNgpgiPEEELErIFERFYRGDNSRGEGgtGLGLAIVKRIVEaHGgTIWVE-SEPGGGTTFTVTLPLAES 239
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
151-378 |
6.79e-19 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 88.54 E-value: 6.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 151 SFVLSLIASYLYARMISAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDLyhhllevIDNLEqqkqenlKLEQ 230
Cdd:PRK10549 173 STLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQL-------ASTLE-------KNEQ 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 231 MKVEFLRGASHELKTPLASLKIILENMRDKIGRYkdrDRYLAVSL--------DIVDEMNQivleiLSLSSVQELAGDKE 302
Cdd:PRK10549 239 MRRDFMADISHELRTPLAVLRGELEAIQDGVRKF---TPESVASLqaevgtltKLVDDLHQ-----LSLSDEGALAYRKT 310
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1514708724 303 WIQLDQVLEQILDQYKVLAQSRALTIDNQIPDKA-VYMDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGTHLAV 378
Cdd:PRK10549 311 PVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSAtVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRL 387
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
11-375 |
3.46e-18 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 86.76 E-value: 3.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 11 FLITFALFSSLVILLHASVYFIFPSTYIESQRQTILKKSQALAKSFQGQEEGTIESVIDLYSKTNDIKVSIKGKQKQNAL 90
Cdd:COG4251 68 LLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLAL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 91 EVKDDLLVNPDSQNNSLVIEERKIQTKEGKDLTLQFLATVDSQKEARDISLGFLPYSLLASFVLSLIASYLYARMISAPI 170
Cdd:COG4251 148 ALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 171 LEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDLYHHLLEVIDNLEQQKQEnlkLEQmkveFLRGASHELKTPLAS- 249
Cdd:COG4251 228 LLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEE---LEQ----FAYVASHDLREPLRKi 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 250 ---LKIILENMRDKIGryKDRDRYLAVSLDIVDEMNQIVLEILSLSSVQELAGDKEWIQLDQVLEQILDQYKVLAQSRAL 326
Cdd:COG4251 301 sgfSQLLEEDYGDKLD--EEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGA 378
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1514708724 327 TIDNQiPDKAVYMDPAILKLVLSNVISNAVKHSDAG--GEIQLRLEEEGTH 375
Cdd:COG4251 379 EIEVG-PLPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGE 428
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
147-410 |
6.38e-13 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 70.11 E-value: 6.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 147 SLLASFVLSLIAsYLYARMISAPILEIKQMTKRM------KRLDRTaNLPIhsqdEIGVLKQQINDLyhhllevIDNLEQ 220
Cdd:TIGR01386 170 AVLLVLLTALLG-WWITRLGLEPLRRLSAVAARIspesldQRLDPS-RAPA----ELRELAQSFNAM-------LGRLED 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 221 QKQenlKLEQmkveFLRGASHELKTPLASLKiilenMRDKIGRYKDRD--RYLAV---SLDIVDEMNQIVLEILSLSSVQ 295
Cdd:TIGR01386 237 AFQ---RLSQ----FSADLAHELRTPLTNLL-----GQTQVALSQPRTgeEYREVlesNLEELERLSRMVSDMLFLARAD 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 296 E--LAGDKEWIQLDQVLEQILDQYKVLAQSRALTIDNQIpDKAVYMDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEG 373
Cdd:TIGR01386 305 NgqLALERVRLDLAAELAKVAEYFEPLAEERGVRIRVEG-EGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRS 383
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1514708724 374 TH--LAVENTsqeMVEIAEMPMT----------ASRQKKE--GGLGLFVVQ 410
Cdd:TIGR01386 384 DEvrVSVSNP---GPGIPPEHLSrlfdrfyrvdPARSNSGegTGLGLAIVR 431
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
339-437 |
9.62e-11 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 58.81 E-value: 9.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 339 MDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGTH--LAVENT----SQEMVEIAEMPM----TASRQKKEGGLGLFV 408
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHveITVEDNgpgiPPEDLEKIFEPFfrtdKRSRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|.
gi 1514708724 409 VQHLLD-HE-ELAYQfDKTAMGLRFRMELPK 437
Cdd:smart00387 81 VKKLVElHGgEISVE-SEPGGGTTFTITLPL 110
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
339-439 |
1.24e-10 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 58.15 E-value: 1.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 339 MDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGT-HLAVENTS-----QEMVEIAEMPMTASRQKKEG-GLGLFVVQH 411
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGElTLTVEDNGigippEDLPRIFEPFSTADKRGGGGtGLGLSIVRK 80
|
90 100 110
....*....|....*....|....*....|
gi 1514708724 412 LLD--HEELAYQfDKTAMGLRFRMELPKDP 439
Cdd:pfam02518 81 LVEllGGTITVE-SEPGGGTTVTLTLPLAQ 109
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
229-292 |
4.90e-10 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 55.30 E-value: 4.90e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1514708724 229 EQMKVEFLRGASHELKTPLASLKIILENMRDKIGRYKDRDRYLAVSLDIVDEMNQIVLEILSLS 292
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLS 64
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
5-424 |
1.57e-06 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 50.23 E-value: 1.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 5 SIFAKI---FLITFALFSSLVILLHASVyfifpstyIESQRQTILKKSQALAKSFQGQEEGTIESVID--------LYSK 73
Cdd:NF038389 2 SIFFKItilFAIALVSVSALFLILLKYQ--------KENYNEELNKKYSLIANTLLQLYQKNINEEELekylknfgFMPI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 74 TNDIKVSIKGKQKQNALEVKDDLLVNPDSQNNSLVIeerKIQTKeGKDLTLQflatvdsqkearDISLGFLPYSLLASFV 153
Cdd:NF038389 74 TDKKLEKEILEIGKNKFILKENGSFRILKYNDKIYL---LIKND-GFSLLLE------------DNEKKSYRYYYIIVFF 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 154 LSLIA--SYLYARMISApILEIKQMTKRMKRLDRTANLPIHSQ---DEIGvlkqQINDLYHHLLEVIDNLEQQKQenlkL 228
Cdd:NF038389 138 IFLILllLILYISVLKS-LKPLKKLKKQIKKFANGDFDFIKSEsngDEIG----EVANEFDKAVKKIKALNESRQ----L 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 229 eqmkveFLRGASHELKTPLASLKIILENMRDKigryKDRDRYLAV--SLDI-VDEMNQIvlEILSlSSVQELagDKEWIQ 305
Cdd:NF038389 209 ------FLRNIMHELKTPITKGRIVAEMLEDE----KQKERLISIfeRLESlINEFAKI--EQLT-SKNYKL--NKKEYR 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 306 LDQVLEQILDqyKVLAQSRALTIDNQIPDKAVYMDPAILKLVLSNVISNAVKHSDaGGEIQLRLEEEgtHLAVENTSQEM 385
Cdd:NF038389 274 LSDIIDEAID--MLMIDDSSVIIKVSLEDFKLNVDFELFSLAIKNLIDNAIKYSP-DKKVTIEIKGD--KIEFKNKGEPL 348
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1514708724 386 VEIAEM---PMTASRQKKEG--GLGLFVVQHLLD--HEELAYQFDK 424
Cdd:NF038389 349 EEPLEYyfePFFKGNEKSKSgfGLGLYIVKNILKahGFKLEYEYEN 394
|
|
| HAMP |
pfam00672 |
HAMP domain; |
161-213 |
1.74e-06 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 44.92 E-value: 1.74e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1514708724 161 LYARMISAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDLYHHLLE 213
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
167-211 |
3.98e-05 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 40.89 E-value: 3.98e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1514708724 167 SAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDLYHHL 211
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
164-216 |
2.95e-04 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 38.38 E-value: 2.95e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1514708724 164 RMISAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDLYHHLLEVID 216
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
218-440 |
2.71e-38 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 138.89 E-value: 2.71e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 218 LEQQKQENLKLEQMKVEFLRGASHELKTPLASLKIILENMRDKIGRYK-DRDRYLAVSLDIVDEMNQIVLEILSLSSVQ- 295
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPeERRELLEIIRESAERLLRLIEDLLDLSRLEs 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 296 -ELAGDKEWIQLDQVLEQILDQYKVLAQSRALTIDNQIPDKA--VYMDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEE 372
Cdd:COG2205 82 gKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELplVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1514708724 373 GTH--LAVENT----SQEMVE-IAEMPMTASRQKKEG--GLGLFVVQHLLD-HE-ELAYQfDKTAMGLRFRMELPKDPQ 440
Cdd:COG2205 162 GDGvrISVSDNgpgiPEEELErIFERFYRGDNSRGEGgtGLGLAIVKRIVEaHGgTIWVE-SEPGGGTTFTVTLPLAES 239
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
107-440 |
1.86e-35 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 135.07 E-value: 1.86e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 107 LVIEERKIQTKEGKDLTLQFLATVDSQKEARDISLGFLPYSLLASFVLSLIASYLYARMISAPILEIKQMTKRMKRLDRT 186
Cdd:COG5002 39 LLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 187 ANLPIHSQDEIGVLKQQINDLYHHLLEVIDNLEQQKQENLK-LEQMKVEFLRGASHELKTPLASLKIILENMRDKIGR-Y 264
Cdd:COG5002 119 LLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELErLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADdP 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 265 KDRDRYLAVSLDIVDEMNQIVLEILSLSSVQ--ELAGDKEWIQLDQVLEQILDQYKVLAQSRALTIDNQIPDKA--VYMD 340
Cdd:COG5002 199 EERREYLEIILEEAERLSRLVNDLLDLSRLEsgELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPllVLGD 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 341 PAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGTH--LAVENT----SQEmveiaEMPM--------TASRQKKEG--GL 404
Cdd:COG5002 279 PDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQvrISVRDTgigiPEE-----DLPRiferfyrvDKSRSRETGgtGL 353
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1514708724 405 GLFVVQHLLD-HE---ELAYQFDKtamGLRFRMELPKDPQ 440
Cdd:COG5002 354 GLAIVKHIVEaHGgriWVESEPGK---GTTFTITLPLARE 390
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
124-437 |
2.03e-33 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 128.10 E-value: 2.03e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 124 LQFLATVDSQKEARDISLGFLPYSLLASFVLSLIASYLYARMISAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQ 203
Cdd:COG0642 2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 204 INDLYHHLLEVIDNLEQQKQENLKLEQMKVEFLRGASHELKTPLASLKIILENMRDKIGryKDRDRYLAVSLDIVDEMNQ 283
Cdd:COG0642 82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELD--EEQREYLETILRSADRLLR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 284 IVLEILSLSSVQ--ELAGDKEWIQLDQVLEQILDQYKVLAQSRALTIDNQIPDKA--VYMDPAILKLVLSNVISNAVKHS 359
Cdd:COG0642 160 LINDLLDLSRLEagKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLptVRGDPDRLRQVLLNLLSNAIKYT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 360 DAGGEIQLRLEEEGTH--LAVENT----SQEMVE-IAEMPMTASRQKKEG--GLGLFVVQHLLD-HE---ELAYQFDKta 426
Cdd:COG0642 240 PEGGTVTVSVRREGDRvrISVEDTgpgiPPEDLErIFEPFFRTDPSRRGGgtGLGLAIVKRIVElHGgtiEVESEPGK-- 317
|
330
....*....|.
gi 1514708724 427 mGLRFRMELPK 437
Cdd:COG0642 318 -GTTFTVTLPL 327
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
151-378 |
6.79e-19 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 88.54 E-value: 6.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 151 SFVLSLIASYLYARMISAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDLyhhllevIDNLEqqkqenlKLEQ 230
Cdd:PRK10549 173 STLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQL-------ASTLE-------KNEQ 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 231 MKVEFLRGASHELKTPLASLKIILENMRDKIGRYkdrDRYLAVSL--------DIVDEMNQivleiLSLSSVQELAGDKE 302
Cdd:PRK10549 239 MRRDFMADISHELRTPLAVLRGELEAIQDGVRKF---TPESVASLqaevgtltKLVDDLHQ-----LSLSDEGALAYRKT 310
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1514708724 303 WIQLDQVLEQILDQYKVLAQSRALTIDNQIPDKA-VYMDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGTHLAV 378
Cdd:PRK10549 311 PVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSAtVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRL 387
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
11-375 |
3.46e-18 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 86.76 E-value: 3.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 11 FLITFALFSSLVILLHASVYFIFPSTYIESQRQTILKKSQALAKSFQGQEEGTIESVIDLYSKTNDIKVSIKGKQKQNAL 90
Cdd:COG4251 68 LLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLAL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 91 EVKDDLLVNPDSQNNSLVIEERKIQTKEGKDLTLQFLATVDSQKEARDISLGFLPYSLLASFVLSLIASYLYARMISAPI 170
Cdd:COG4251 148 ALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 171 LEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDLYHHLLEVIDNLEQQKQEnlkLEQmkveFLRGASHELKTPLAS- 249
Cdd:COG4251 228 LLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEE---LEQ----FAYVASHDLREPLRKi 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 250 ---LKIILENMRDKIGryKDRDRYLAVSLDIVDEMNQIVLEILSLSSVQELAGDKEWIQLDQVLEQILDQYKVLAQSRAL 326
Cdd:COG4251 301 sgfSQLLEEDYGDKLD--EEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGA 378
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1514708724 327 TIDNQiPDKAVYMDPAILKLVLSNVISNAVKHSDAG--GEIQLRLEEEGTH 375
Cdd:COG4251 379 EIEVG-PLPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGE 428
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
148-441 |
9.66e-18 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 84.63 E-value: 9.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 148 LLASFVLSLIASYLYARMISAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDL-------------YHHLLE- 213
Cdd:COG5000 15 ALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMtdqlkeqreeleeRRRYLEt 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 214 VIDNL-------------------------------------------------------EQQKQENLKLEQMKV----- 233
Cdd:COG5000 95 ILENLpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealerGWQEEIELTRDGRRTllvra 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 234 ----------------------------EFLRGASHELKTPLASLKIILENMRDKIGRY-----KDRDRYLAVSLDIVDE 280
Cdd:COG5000 175 splrddgyvivfdditellraerlaawgELARRIAHEIKNPLTPIQLSAERLRRKLADKleedrEDLERALDTIIRQVDR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 281 MNQIVLEILSLSSVQELagDKEWIQLDQVLEQILDQYKVLAQSRALTIDNQIPDKA--VYMDPAILKLVLSNVISNAVKH 358
Cdd:COG5000 255 LKRIVDEFLDFARLPEP--QLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpeVLADRDQLEQVLINLLKNAIEA 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 359 SDAGGEIQLRLEEEGTH--LAVENT----SQEMVE-IAEmP-MTAsrqKKEG-GLGLFVVQHLL-DHE-ELAYQfDKTAM 427
Cdd:COG5000 333 IEEGGEIEVSTRREDGRvrIEVSDNgpgiPEEVLErIFE-PfFTT---KPKGtGLGLAIVKKIVeEHGgTIELE-SRPGG 407
|
410
....*....|....
gi 1514708724 428 GLRFRMELPKDPQE 441
Cdd:COG5000 408 GTTFTIRLPLAEEA 421
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
133-436 |
1.08e-14 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 76.60 E-value: 1.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 133 QKEARDISLGFLPYSLLASFVLSLIASYLYARMISAPILEIkqmtkrMKRLDRTA------NLPIHSQDEIGvlkqQIND 206
Cdd:PRK15347 288 ANEALKPALQQLPFALLILVLLTSVLFLLLRRYLAKPLWRF------VDIINKTGpaalepRLPENRLDELG----SIAK 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 207 LYHHLLEVI----DNLEQQ-----------KQENLKLEQMKVEFLRGASHELKTPL----ASLKiILEN--MRDKIGRYK 265
Cdd:PRK15347 358 AYNQLLDTLneqyDTLENKvaertqalaeaKQRAEQANKRKSEHLTTISHEIRTPLngvlGALE-LLQNtpLTAEQMDLA 436
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 266 DRDRYLAVSL-----DIVD----EMNQIVLEIlslssvqelagdkEWIQLDQVLEQILDQYKVLAQSRALT----IDNQI 332
Cdd:PRK15347 437 DTARQCTLSLlaiinNLLDfsriESGQMTLSL-------------EETALLPLLDQAMLTIQGPAQSKSLTlrtfVGAHV 503
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 333 PDKAvYMDPAILKLVLSNVISNAVKHSDAGGeIQLRLEEEGTHLA--VENTS-----QEMVEIAEMPMTASRQKKEGGLG 405
Cdd:PRK15347 504 PLYL-HLDSLRLRQILVNLLGNAVKFTETGG-IRLRVKRHEQQLCftVEDTGcgidiQQQQQIFTPFYQADTHSQGTGLG 581
|
330 340 350
....*....|....*....|....*....|...
gi 1514708724 406 LFVVQHL--LDHEELAYqFDKTAMGLRFRMELP 436
Cdd:PRK15347 582 LTIASSLakMMGGELTL-FSTPGVGSCFSLVLP 613
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
209-410 |
1.53e-14 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 74.50 E-value: 1.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 209 HHLLEVIDNLEQQK---QENLKLEQMKV--EFLRGASHELKTPLASLKIILENMRDKIGRYKDRDrYLAVSLDIVDEMNQ 283
Cdd:COG3852 107 GGVLLVLRDITERKrleRELRRAEKLAAvgELAAGLAHEIRNPLTGIRGAAQLLERELPDDELRE-YTQLIIEEADRLNN 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 284 IVLEILSLSSVQELagDKEWIQLDQVLEQILDqykvLAQSRA-------LTIDNQIPDkaVYMDPAILKLVLSNVISNAV 356
Cdd:COG3852 186 LVDRLLSFSRPRPP--EREPVNLHEVLERVLE----LLRAEApknirivRDYDPSLPE--VLGDPDQLIQVLLNLVRNAA 257
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1514708724 357 KHSDAGGEIQLRLEEEGTHLAVENTSQEMVEI----------AEM------PM--TasrqKKEG-GLGLFVVQ 410
Cdd:COG3852 258 EAMPEGGTITIRTRVERQVTLGGLRPRLYVRIevidngpgipEEIldrifePFftT----KEKGtGLGLAIVQ 326
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
241-381 |
6.19e-14 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 73.34 E-value: 6.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 241 HELKTPLASLK----IILENMRDKigrykDRDRYLAvslDIVDE---MNQIVLEILSLSSV---QELAgDKEWIQLDQVL 310
Cdd:PRK11100 265 HELKSPLAAIRgaaeLLQEDPPPE-----DRARFTG---NILTQsarLQQLIDRLLELARLeqrQELE-VLEPVALAALL 335
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1514708724 311 EQILDQYKVLAQSRALTIDNQIPDKAVYMDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGTH--LAVENT 381
Cdd:PRK11100 336 EELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQvaLSVEDQ 408
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
122-379 |
2.60e-13 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 70.98 E-value: 2.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 122 LTLQFLATVDSQKEARDISLGFLPYSLLASFVLSLIASYLYARMISAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLK 201
Cdd:COG4191 20 LALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 202 QQINDLYHHLLEVIDNLEQQKQENLKLEQMKVEFLR------------GASHELKTPLASLKIILENMRDKIGRYKDRD- 268
Cdd:COG4191 100 ALDAEENAELEELERDITELERAEEELRELQEQLVQseklaalgelaaGIAHEINNPLAAILGNAELLRRRLEDEPDPEe 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 269 --RYLAVSLDIVDEMNQIVLEILSLSSVQELagDKEWIQLDQVLEQILDQYKVLAQSRALTIDNQIPDK--AVYMDPAIL 344
Cdd:COG4191 180 lrEALERILEGAERAAEIVRSLRAFSRRDEE--EREPVDLNELIDEALELLRPRLKARGIEVELDLPPDlpPVLGDPGQL 257
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1514708724 345 KLVLSNVISNAVkhsDA-----GGEIQLRLEEEGTHLAVE 379
Cdd:COG4191 258 EQVLLNLLINAI---DAmeegeGGRITISTRREGDYVVIS 294
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
211-437 |
4.79e-13 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 70.42 E-value: 4.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 211 LLEVIDNLEQQKQenlkLEQMKVEFLRGASHELKTPLASLKIILENMRDKIGRYKDRDRYLAVSLDIVDEMNQIVLEILS 290
Cdd:PRK11006 187 LLMVARDVTQMHQ----LEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLT 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 291 LSSVqELAGDkewIQLDQVLE-----QILDQYKV-LAQSR---ALTIDNQIpdkAVYMDPAILKLVLSNVISNAVKHSDA 361
Cdd:PRK11006 263 LSKI-EAAPT---IDLNEKVDvpmmlRVLEREAQtLSQGKhtiTFEVDNSL---KVFGNEDQLRSAISNLVYNAVNHTPE 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 362 GGEIQLRLEE--EGTHLAVENTSQEmVEIAEMP-MTA---------SRQKKEGGLGLFVVQHLLDHEELAYQFD-KTAMG 428
Cdd:PRK11006 336 GTHITVRWQRvpQGAEFSVEDNGPG-IAPEHIPrLTErfyrvdkarSRQTGGSGLGLAIVKHALSHHDSRLEIEsEVGKG 414
|
....*....
gi 1514708724 429 LRFRMELPK 437
Cdd:PRK11006 415 TRFSFVLPE 423
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
147-410 |
6.38e-13 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 70.11 E-value: 6.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 147 SLLASFVLSLIAsYLYARMISAPILEIKQMTKRM------KRLDRTaNLPIhsqdEIGVLKQQINDLyhhllevIDNLEQ 220
Cdd:TIGR01386 170 AVLLVLLTALLG-WWITRLGLEPLRRLSAVAARIspesldQRLDPS-RAPA----ELRELAQSFNAM-------LGRLED 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 221 QKQenlKLEQmkveFLRGASHELKTPLASLKiilenMRDKIGRYKDRD--RYLAV---SLDIVDEMNQIVLEILSLSSVQ 295
Cdd:TIGR01386 237 AFQ---RLSQ----FSADLAHELRTPLTNLL-----GQTQVALSQPRTgeEYREVlesNLEELERLSRMVSDMLFLARAD 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 296 E--LAGDKEWIQLDQVLEQILDQYKVLAQSRALTIDNQIpDKAVYMDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEG 373
Cdd:TIGR01386 305 NgqLALERVRLDLAAELAKVAEYFEPLAEERGVRIRVEG-EGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRS 383
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1514708724 374 TH--LAVENTsqeMVEIAEMPMT----------ASRQKKE--GGLGLFVVQ 410
Cdd:TIGR01386 384 DEvrVSVSNP---GPGIPPEHLSrlfdrfyrvdPARSNSGegTGLGLAIVR 431
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
218-368 |
1.11e-12 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 69.62 E-value: 1.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 218 LEQQKQENLKLeQMKVEFLRGASHELKTPLASLKIILENMRDKIgrYKDRDRYLAVSLDIVDEMNQIVLEILSLSSVQel 297
Cdd:COG5809 257 LEELLRKSEKL-SVVGELAAGIAHEIRNPLTSLKGFIQLLKDTI--DEEQKTYLDIMLSELDRIESIISEFLVLAKPQ-- 331
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1514708724 298 AGDKEWIQLDQVLEQILDqykvLAQSRAL--------TIDNQIPDkaVYMDPAILKLVLSNVISNAVKHSDAGGEIQLR 368
Cdd:COG5809 332 AIKYEPKDLNTLIEEVIP----LLQPQALlknvqielELEDDIPD--ILGDENQLKQVFINLLKNAIEAMPEGGNITIE 404
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
1-415 |
2.02e-12 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 68.51 E-value: 2.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 1 MTKRSIFAKIFLITFALFSSLVILLHASVYFIFPSTYIESQRQTILKKSQALAKSFQGQEEGTIESVIDLYSKTNDIKVS 80
Cdd:COG2972 16 ILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLIL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 81 IKGKQKQNALEVKDDLLVNPDSQNNSLVIEERKIQTKEGKDLTLQFLATVDSQKEARDISLGFLPYSLLASFVLSLIASY 160
Cdd:COG2972 96 LLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 161 LYARMISAPILEIKQMTKRMKRLDrTANLPIHSQDEIGVLKQQINDLYHHLLEVIDNLEQQKQENLKLEqmkveflrgas 240
Cdd:COG2972 176 LLSRSITRPIKRLKKAMKKVEKGD-LVRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEAE----------- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 241 helktpLASLKI---------ILENMRdkigrykdrdrYLAVSLDIvDEMNQIVLEILSLSSVQeLAGDKEWIQLDQVLE 311
Cdd:COG2972 244 ------LKALQAqinphflfnTLNSIR-----------WLAELEDP-EEAEEMLEALSKLLRYS-LSKGDELVTLEEELE 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 312 qILDQYKVLAQSRA---LTIDNQIPDKAvyMDPAILKLVLSNVISNAVKH----SDAGGEIQLRLEEEGTHL--AVENTS 382
Cdd:COG2972 305 -LIKSYLEIQKLRFgdrLEVEIEIDEEL--LDLLIPKLILQPLVENAIEHgiepKEGGGTIRISIRKEGDRLviTVEDNG 381
|
410 420 430
....*....|....*....|....*....|....*
gi 1514708724 383 QEMVE--IAEMPMTASRQKKEGGLGLFVVQHLLDH 415
Cdd:COG2972 382 VGMPEekLEKLLEELSSKGEGRGIGLRNVRERLKL 416
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
133-439 |
1.50e-11 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 65.37 E-value: 1.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 133 QKEARDISLGFLPYSLLAsFVLSLIASYLYARMISAPIleiKQMTKRMKRldRTAN----LPIHSQ-DEIGVLKQQINDL 207
Cdd:PRK10755 53 MKEIREAVASLLVPSLVM-VSLTLLICFQAVRWITRPL---AELQKELEA--RTADnltpIAIHSStLEIEAVTSALNQL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 208 YHHLLEVIDnleqqkQENLkleqmkveFLRGASHELKTPLASLKIILENMRDK--------IGRykdrdrylavsldiVD 279
Cdd:PRK10755 127 VSRLTSTLD------QERL--------FTADVAHELRTPLAGIRLHLELLEKQhhidvaplIAR--------------LD 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 280 EMNQIVLEILSLSSV-QELAGDK----EWiqLDQVLEQILDQYKVLAQSRALTIDNQIPDKAVYM--DPAILKLVLSNVI 352
Cdd:PRK10755 179 QMMHTVEQLLQLARAgQSFSSGHyqtvKL--LEDVILPSQDELSEMLEQRQQTLLLPESAADITVqgDATLLRLLLRNLV 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 353 SNAVKHSDAGGEIQLRL--EEEGTHLAVE------NTSQeMVEIAEmPMTASRQKKEG-GLGLFVVQHL--LDHEELAYQ 421
Cdd:PRK10755 257 ENAHRYSPEGSTITIKLsqEDGGAVLAVEdegpgiDESK-CGELSK-AFVRMDSRYGGiGLGLSIVSRItqLHHGQFFLQ 334
|
330
....*....|....*...
gi 1514708724 422 FDKTAMGLRFRMELPKDP 439
Cdd:PRK10755 335 NRQERSGTRAWVWLPKAQ 352
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
339-437 |
9.62e-11 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 58.81 E-value: 9.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 339 MDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGTH--LAVENT----SQEMVEIAEMPM----TASRQKKEGGLGLFV 408
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHveITVEDNgpgiPPEDLEKIFEPFfrtdKRSRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|.
gi 1514708724 409 VQHLLD-HE-ELAYQfDKTAMGLRFRMELPK 437
Cdd:smart00387 81 VKKLVElHGgEISVE-SEPGGGTTFTITLPL 110
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
339-439 |
1.24e-10 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 58.15 E-value: 1.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 339 MDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGT-HLAVENTS-----QEMVEIAEMPMTASRQKKEG-GLGLFVVQH 411
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGElTLTVEDNGigippEDLPRIFEPFSTADKRGGGGtGLGLSIVRK 80
|
90 100 110
....*....|....*....|....*....|
gi 1514708724 412 LLD--HEELAYQfDKTAMGLRFRMELPKDP 439
Cdd:pfam02518 81 LVEllGGTITVE-SEPGGGTTVTLTLPLAQ 109
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
213-436 |
1.69e-10 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 63.21 E-value: 1.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 213 EVIDNLEQQKQENLKLEQMKVEFLRGASHELKTPLASLKIILENMRDKIGRYKDRDRYLAVSLDIVDEMNQIVLEILSLS 292
Cdd:PRK09959 693 DLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVD 772
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 293 SVQE--LAGDKEWIQLDQVLEQILDQYKVLAQSR--ALTIDNQIPDK-AVYMDPAILKLVLSNVISNAVKHSDAG----- 362
Cdd:PRK09959 773 KIESgnYQLQPQWVDIPTLVQNTCHSFGAIAASKsiALSCSSTFPDHyLVKIDPQAFKQVLSNLLSNALKFTTEGavkit 852
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 363 ----------GEIQLRLEEEGTHLAVENTSQEMVEIAEmpMTASRQKKEGGLGLFVVQHLLDHEELAYQFDK-TAMGLRF 431
Cdd:PRK09959 853 tslghiddnhAVIKMTIMDSGSGLSQEEQQQLFKRYSQ--TSAGRQQTGSGLGLMICKELIKNMQGDLSLEShPGIGTTF 930
|
....*
gi 1514708724 432 RMELP 436
Cdd:PRK09959 931 TITIP 935
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
225-437 |
3.97e-10 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 61.71 E-value: 3.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 225 NLKLEQMKVEFLRGA------SHELKTPLASL----KIILENMRDKigryKDRDRYLAVSLDIVDEMNQIVLEILSLSSV 294
Cdd:PRK09835 249 NHMIERIEDVFTRQSnfsadiAHEIRTPITNLitqtEIALSQSRSQ----KELEDVLYSNLEELTRMAKMVSDMLFLAQA 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 295 --QELAGDKEWIQLDQVLEQILDQYKVLAQSRALTIDNQIPDKAVYMDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEe 372
Cdd:PRK09835 325 dnNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQE- 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 373 gthlaVENTSQEMVEIAEMPMTA---------------SRQKK-EG-GLGLFVVQHLLDHEELAYQFDKTAMGLRFRMEL 435
Cdd:PRK09835 404 -----VDHQVQLVVENPGTPIAPehlprlfdrfyrvdpSRQRKgEGsGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISL 478
|
..
gi 1514708724 436 PK 437
Cdd:PRK09835 479 PR 480
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
229-292 |
4.90e-10 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 55.30 E-value: 4.90e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1514708724 229 EQMKVEFLRGASHELKTPLASLKIILENMRDKIGRYKDRDRYLAVSLDIVDEMNQIVLEILSLS 292
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLS 64
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
211-367 |
3.74e-09 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 58.04 E-value: 3.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 211 LLEVIDNLEQQKQENLKL-EQMKVE--FLRGASHELKTPLASLKIILE------NMRDKIGRYKDRDRYLAVSLDIVDEM 281
Cdd:PRK09303 127 LLQLSDELFVLRQENETLlEQLKFKdrVLAMLAHDLRTPLTAASLALEtlelgqIDEDTELKPALIEQLQDQARRQLEEI 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 282 NQIVLEIL--SLSSVQELAGDKEWIQLDQVLEQILDQYKVLAQSRALTIDNQIPDK--AVYMDPAILKLVLSNVISNAVK 357
Cdd:PRK09303 207 ERLITDLLevGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDlpSVYADQERIRQVLLNLLDNAIK 286
|
170
....*....|
gi 1514708724 358 HSDAGGEIQL 367
Cdd:PRK09303 287 YTPEGGTITL 296
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
235-410 |
4.17e-09 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 58.12 E-value: 4.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 235 FLRGASHELKTPLASLKIILE----NMRDKIGrykdRDRYLAvSLDI-VDEMNQIVLEILSLSSVQELA--GDKEWIQLD 307
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTEvaqlSDDDPQA----RKKALL-QLHAgIDRATRLVDQLLTLSRLDSLDnlQDVAEIPLE 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 308 QVLEQ-ILDQYKvLAQSRALTIDNQIPDKAVYM--DPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGTHLAvEN---- 380
Cdd:PRK10337 315 DLLQSaVMDIYH-TAQQAGIDVRLTLNAHPVIRtgQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVR-DNgpgv 392
|
170 180 190
....*....|....*....|....*....|.
gi 1514708724 381 TSQEMVEIAEMPMTASRQKKEG-GLGLFVVQ 410
Cdd:PRK10337 393 TPEALARIGERFYRPPGQEATGsGLGLSIVR 423
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
288-439 |
9.77e-09 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 57.22 E-value: 9.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 288 ILSLSSVQE-LAGDKEW--IQLDQVLEQILDQYKVLAQSRALTIDNQIPDKAVYMDPAI-LKLVLSNVISNAVKH---SD 360
Cdd:COG3920 340 IQALALVHElLYQSEDWegVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVELPADAAVpLGLILNELVTNALKHaflSG 419
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 361 AGGEIQLRLEEEGTHLaventsqeMVEIAE----MPMTASRQKKEgGLGLFVVqhlldhEELAYQFD-----KTAMGLRF 431
Cdd:COG3920 420 EGGRIRVSWRREDGRL--------RLTVSDngvgLPEDVDPPARK-GLGLRLI------RALVRQLGgtlelDRPEGTRV 484
|
....*...
gi 1514708724 432 RMELPKDP 439
Cdd:COG3920 485 RITFPLAE 492
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-436 |
2.01e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 51.82 E-value: 2.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 344 LKLVLSNVISNAVKHSDAGGEIQLRL--EEEGTHLAVENTS-----QEMVEIAE----MPMTASRQKKEGGLGLFVVQHL 412
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWsqEESGARLSVEDTGpgippEHIPRLTErfyrVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 1514708724 413 LDHEELAYQFDKT-AMGLRFRMELP 436
Cdd:cd16952 81 MSRHDARLLIASElGKGSRFTCLFP 105
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
234-441 |
5.50e-08 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 54.97 E-value: 5.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 234 EFLRGASHELKTPLASLK----IILENMRDKIGRykdrdRYLAVSLDIVDEMNQIVLEILSLSSVQELAGDKewIQLDQV 309
Cdd:PRK11360 392 ELVAGVAHEIRNPLTAIRgyvqIWRQQTSDPPSQ-----EYLSVVLREVDRLNKVIDQLLEFSRPRESQWQP--VSLNAL 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 310 LEQILDQYKVLAQSRALTI----DNQIPdkAVYMDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGT---HLAVENTS 382
Cdd:PRK11360 465 VEEVLQLFQTAGVQARVDFetelDNELP--PIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDgqvAVSIEDNG 542
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1514708724 383 -----QEMVEIAEmPMTASRQKKEgGLGLFVVQHLLDheelAYQFDKTA-----MGLRFRMELPKDPQE 441
Cdd:PRK11360 543 cgidpELLKKIFD-PFFTTKAKGT-GLGLALSQRIIN----AHGGDIEVesepgVGTTFTLYLPINPQG 605
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
87-423 |
9.57e-08 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 54.12 E-value: 9.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 87 QNALEVKDDLLVNPDSQNNSLVIEERKIQTKEGKDLTLQFLATVDSQKEARDISLGFLPYSLLASFVLSLIASYLYARMI 166
Cdd:COG3850 63 LLLLSLGLLALLLALLLLLLLLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRI 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 167 SAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDLYHHLLEVIDNLEQQKQENLKLEQMKVEFLRGASHELK-- 244
Cdd:COG3850 143 VRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLll 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 245 --TPLASLKIILENMRDKIGRYKDRDRYLAVSLDIVDEMNQIVLEILSLSSVQELAGDKEWIQLDQVLEQILDQYKVLAQ 322
Cdd:COG3850 223 laLLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAE 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 323 SRALTIDNQIPDKAVYMDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGTHLAVENTSQEMVEIAEMPMTASRQKKEG 402
Cdd:COG3850 303 EALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADA 382
|
330 340
....*....|....*....|.
gi 1514708724 403 GLGLFVVQHLLDHEELAYQFD 423
Cdd:COG3850 383 AEALGLLAEASEGAAGQGAGL 403
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
215-381 |
2.02e-07 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 53.20 E-value: 2.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 215 IDNLEQQKQENLKLEQMKV--EFLRGASHELKTPLASLKIILENMRDKIGRYKDrdrYLAVSLDIVDEMNQIVLEILSLS 292
Cdd:COG5805 268 ITEKKEAEELMARSEKLSIagQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEE---YFDIMLSELDRIESIISEFLALA 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 293 SVQELagDKEWIQLDQVLEQILdqykVLAQSRALTIDNQI------PDKAVYMDPAILKLVLSNVISNAVKHSDAGGEIQ 366
Cdd:COG5805 345 KPQAV--NKEKENINELIQDVV----TLLETEAILHNIQIrlelldEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTIT 418
|
170
....*....|....*..
gi 1514708724 367 LRLEEEGT--HLAVENT 381
Cdd:COG5805 419 IHTEEEDNsvIIRVIDE 435
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
238-436 |
3.25e-07 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 52.30 E-value: 3.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 238 GASHELKTPLASLKIILEnMRDKIgrykDRDRYLAVSLDIvDEMNQIVLEILSLSSV--QELAGDKEWIQLDQVLEQILD 315
Cdd:PRK10604 218 GIAHELRTPLVRLRYRLE-MSDNL----SAAESQALNRDI-GQLEALIEELLTYARLdrPQNELHLSEPDLPAWLSTHLA 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 316 QYKVLAQSRALTIDNQIPDKAVYMDPAILKLVLSNVISNAVKHSDA---------GGEIQLRLEEEGTHLAVEntSQEMV 386
Cdd:PRK10604 292 DIQAVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYAHSrvrvsllldGNQACLIVEDDGPGIPPE--ERERV 369
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1514708724 387 EIAEMPMTASRQKKEG--GLGLFVVQHLLDHEELAYQFDKTAM-GLRFRMELP 436
Cdd:PRK10604 370 FEPFVRLDPSRDRATGgcGLGLAIVHSIALAMGGSVNCDESELgGARFSFSWP 422
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
231-296 |
5.46e-07 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 46.44 E-value: 5.46e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1514708724 231 MKVEFLRGASHELKTPLASLKIILENMRDKiGRYKDRDRYLAVSLDIVDEMNQIVLEILSLSSVQE 296
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDE-KLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
231-296 |
7.41e-07 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 46.41 E-value: 7.41e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1514708724 231 MKVEFLRGASHELKTPLASLKIILENMRDKIGRYKDRdRYLAVSLDIVDEMNQIVLEILSLSSVQE 296
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQR-EYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
5-424 |
1.57e-06 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 50.23 E-value: 1.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 5 SIFAKI---FLITFALFSSLVILLHASVyfifpstyIESQRQTILKKSQALAKSFQGQEEGTIESVID--------LYSK 73
Cdd:NF038389 2 SIFFKItilFAIALVSVSALFLILLKYQ--------KENYNEELNKKYSLIANTLLQLYQKNINEEELekylknfgFMPI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 74 TNDIKVSIKGKQKQNALEVKDDLLVNPDSQNNSLVIeerKIQTKeGKDLTLQflatvdsqkearDISLGFLPYSLLASFV 153
Cdd:NF038389 74 TDKKLEKEILEIGKNKFILKENGSFRILKYNDKIYL---LIKND-GFSLLLE------------DNEKKSYRYYYIIVFF 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 154 LSLIA--SYLYARMISApILEIKQMTKRMKRLDRTANLPIHSQ---DEIGvlkqQINDLYHHLLEVIDNLEQQKQenlkL 228
Cdd:NF038389 138 IFLILllLILYISVLKS-LKPLKKLKKQIKKFANGDFDFIKSEsngDEIG----EVANEFDKAVKKIKALNESRQ----L 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 229 eqmkveFLRGASHELKTPLASLKIILENMRDKigryKDRDRYLAV--SLDI-VDEMNQIvlEILSlSSVQELagDKEWIQ 305
Cdd:NF038389 209 ------FLRNIMHELKTPITKGRIVAEMLEDE----KQKERLISIfeRLESlINEFAKI--EQLT-SKNYKL--NKKEYR 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 306 LDQVLEQILDqyKVLAQSRALTIDNQIPDKAVYMDPAILKLVLSNVISNAVKHSDaGGEIQLRLEEEgtHLAVENTSQEM 385
Cdd:NF038389 274 LSDIIDEAID--MLMIDDSSVIIKVSLEDFKLNVDFELFSLAIKNLIDNAIKYSP-DKKVTIEIKGD--KIEFKNKGEPL 348
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1514708724 386 VEIAEM---PMTASRQKKEG--GLGLFVVQHLLD--HEELAYQFDK 424
Cdd:NF038389 349 EEPLEYyfePFFKGNEKSKSgfGLGLYIVKNILKahGFKLEYEYEN 394
|
|
| HAMP |
pfam00672 |
HAMP domain; |
161-213 |
1.74e-06 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 44.92 E-value: 1.74e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1514708724 161 LYARMISAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDLYHHLLE 213
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
44-220 |
3.10e-06 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 49.25 E-value: 3.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 44 TILKKSQALAKSFQGQEEGTIESVIDLYSKTNDIKVSIKGKQKQNALEVKDDLLVNPDSQNNSLVIEERKIQTKEGKDLT 123
Cdd:COG0840 84 LLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAAL 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 124 LQFLATVDSQKEARDISLGFLPYSLLASFVLSLIASYLYARMISAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQ 203
Cdd:COG0840 164 AALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADA 243
|
170
....*....|....*..
gi 1514708724 204 INDLYHHLLEVIDNLEQ 220
Cdd:COG0840 244 FNRMIENLRELVGQVRE 260
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
133-436 |
9.16e-06 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 47.98 E-value: 9.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 133 QKEARDISLGFLPYSLLASFVLSLIASYLYARMISAPILEIKQMTKRMKRLDRTANLP----IHSQDEIGVL----KQQI 204
Cdd:PRK11466 323 EKASARGQYSLLLLGMVSLCALILILWRVVYRSVTRPLAEQTQALQRLLDGDIDSPFPetagVRELDTIGRLmdafRSNV 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 205 NDLYHH--------------LLEVIDNLEQQKQENLKLEQMKVEFLRGASHELKTPLASLKIILENMRDKIGRYKDRDRY 270
Cdd:PRK11466 403 HALNRHreqlaaqvkartaeLQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDL 482
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 271 LAVSlDIVDEMNQIVLEILSLSSVQelAGDKEWIQLDQVLE--QILDQYKVLA----QSRALTIDNQIPDK---AVYMDP 341
Cdd:PRK11466 483 RAIT-DSGESLLTILNDILDYSAIE--AGGKNVSVSDEPFEprPLLESTLQLMsgrvKGRPIRLATDIADDlptALMGDP 559
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 342 AILKLVLSNVISNAVKHSDAgGEIQLRLEEEGTH--LAVENTS-----QEMVEIAEMPMTASRQKKEGGLGLFVVQHLLd 414
Cdd:PRK11466 560 RRIRQVITNLLSNALRFTDE-GSIVLRSRTDGEQwlVEVEDSGcgidpAKLAEIFQPFVQVSGKRGGTGLGLTISSRLA- 637
|
330 340
....*....|....*....|....*
gi 1514708724 415 hEELAYQFDKTA---MGLRFRMELP 436
Cdd:PRK11466 638 -QAMGGELSATStpeVGSCFCLRLP 661
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
340-410 |
1.31e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 43.99 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 340 DPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGTH--LAVENTSQEMVEIA---------EMPMTASrQKKEGGLGLFV 408
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGieLLVFDEGSGIPDYAlnrvferfySLPRPHS-GQKSTGLGLAF 79
|
..
gi 1514708724 409 VQ 410
Cdd:cd16945 80 VQ 81
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
10-419 |
1.56e-05 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 47.42 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 10 IFLITFALFSSLVILLHASVYFIFPSTYIESQRQTILKKSQALAKSFQGQEEGTIESVIDLYSKTNDIKVSIKGKQKQNA 89
Cdd:COG2770 80 LLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLA 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 90 LEVKDDLLVNPDSQNNSLVIEERKIQTKEGKDLTLQFLATVDSQKEARDISLGFLPYSLLASFVLSLIASYLYARMISAP 169
Cdd:COG2770 160 LAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRP 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 170 ILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDLYHHLLEVIDnlEQQKQENLKLEQMKVEFLRGASHELKTPLAS 249
Cdd:COG2770 240 LRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIE--EAEEEEELAEAELARLLEALLELLLALLLLL 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 250 LKIILENMRDKIGRYKDRDRYLAVSLDIVDEMNQIVLEILSLSSVQELAGDKEWIQLDQVLEQILDQYKVLAQSRALTID 329
Cdd:COG2770 318 LALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAA 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 330 NQIPDKAVYMDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGTHLAVENTSQEMVEIAEMPMTASRQKKEGGLGLFVV 409
Cdd:COG2770 398 LAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAA 477
|
410
....*....|
gi 1514708724 410 QHLLDHEELA 419
Cdd:COG2770 478 LLLLAALGAL 487
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
167-211 |
3.98e-05 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 40.89 E-value: 3.98e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1514708724 167 SAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDLYHHL 211
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
344-415 |
5.79e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 42.59 E-value: 5.79e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1514708724 344 LKLVLSNVISNAVKHS---DAGGEIQLRLEEEGTHLAVE----NTSQEMVEIAEMPMTASrqkkEGGLGLFVVQHLLDH 415
Cdd:COG2172 35 LVLAVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEvrdeGPGFDPEDLPDPYSTLA----EGGRGLFLIRRLMDE 109
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
148-373 |
7.04e-05 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 44.90 E-value: 7.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 148 LLASFVLSLIASYLYARMISAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDLYHHLlevidnleqqKQenlk 227
Cdd:PRK09467 159 TLAIGLLSVAGGWLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGI----------KQ---- 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 228 LEQMKVEFLRGASHELKTPLASLKIILENMRDKigrykdrDRYLAVSL--DIvDEMNQIVLEILS-LSSVQElaGDKEWI 304
Cdd:PRK09467 225 LEDDRTLLMAGVSHDLRTPLTRIRLATEMMSEE-------DGYLAESInkDI-EECNAIIEQFIDyLRTGQE--MPMEMA 294
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1514708724 305 QLDQVLEQIldqykVLAQS-RALTIDNQIPD--KAVYMDPAILKLVLSNVISNAVKHSdaGGEIQLRLEEEG 373
Cdd:PRK09467 295 DLNALLGEV-----IAAESgYEREIETALQPgpIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEG 359
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
344-415 |
8.88e-05 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 41.10 E-value: 8.88e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1514708724 344 LKLVLSNVISNAVKH---SDAGGEIQLRLEEEGTHLAVE--NTSQEMVEIAemPMTASRQKKEGGLGLFVVQHLLDH 415
Cdd:cd16936 1 VELAVSEAVTNAVRHayrHDGPGPVRLELDLDPDRLRVEvtDSGPGFDPLR--PADPDAGLREGGRGLALIRALMDE 75
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-436 |
1.26e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 40.90 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 344 LKLVLSNVISNAVKHsdAGGEIQLRLEEEGTHLA--VENTSQ----EMVEIAEMPMT---ASRQKKEGGLGLFVVQHLLD 414
Cdd:cd16950 1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRiqVLDNGPgiapEEVDELFQPFYrgdNARGTSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|....*.
gi 1514708724 415 HE----ELAyqfDKTAMGLRFRMELP 436
Cdd:cd16950 79 AHggslTLA---NRAGGGLCARIELP 101
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
240-379 |
2.03e-04 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 43.38 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 240 SHELKTPLASLKIILENMRDKIGRYKDRDRylavsldIVDE---MNQIVLEILSLSSVQ---ELagDKEWIQLDQVLEQI 313
Cdd:PRK09470 251 SHELRTPLTRLQLATALLRRRQGESKELER-------IETEaqrLDSMINDLLVLSRNQqknHL--ERETFKANSLWSEV 321
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1514708724 314 LDQYKVLAQSRALTID-NQIPDK-AVYMDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGTHLAVE 379
Cdd:PRK09470 322 LEDAKFEAEQMGKSLTvSAPPGPwPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVD 389
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
164-216 |
2.95e-04 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 38.38 E-value: 2.95e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1514708724 164 RMISAPILEIKQMTKRMKRLDRTANLPIHSQDEIGVLKQQINDLYHHLLEVID 216
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
238-440 |
3.85e-04 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 42.47 E-value: 3.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 238 GASHELKTPLASLKIILENM--RDKIGrykDRDRYLA-VSLDIVDEMNQIVLEILSLSSVQELAgdKEWIQLDQVLEQIL 314
Cdd:PRK10364 243 GVAHEIRNPLSSIKGLAKYFaeRAPAG---GEAHQLAqVMAKEADRLNRVVSELLELVKPTHLA--LQAVDLNDLINHSL 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 315 DQYKVLAQSRALTIDNQIPD--KAVYMDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGTH--LAVENT-----SQEM 385
Cdd:PRK10364 318 QLVSQDANSREIQLRFTANDtlPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGvkISVTDSgkgiaADQL 397
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1514708724 386 VEIAEMPMTAsrqKKEG-GLGLFVVQHLLDHEELAYQFD-KTAMGLRFRMELP-----KDPQ 440
Cdd:PRK10364 398 EAIFTPYFTT---KAEGtGLGLAVVHNIVEQHGGTIQVAsQEGKGATFTLWLPvnitrRDPQ 456
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
344-433 |
4.13e-04 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 39.96 E-value: 4.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 344 LKLVLSNVISNAVKH---SDAGGEIQLRLEEEGTHLAVE----NTSQEMVEIAEMPMTASRQK-KEGGLGLFVVQHLLDh 415
Cdd:pfam13581 32 VELAVGEACTNAVEHayrEGPEGPVEVRLTSDGGGLVVTvadsGPPFDPLTLPPPDLEEPDEDrKEGGRGLALIRGLMD- 110
|
90
....*....|....*...
gi 1514708724 416 eELAYQFDKTAMGLRFRM 433
Cdd:pfam13581 111 -DVEYTRGGEGNTVRMRK 127
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
218-440 |
4.19e-04 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 42.53 E-value: 4.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 218 LEQQKQEnlkLEQMK--VEFLRGASHELKTPLASLKIILENmrdkiGRYKDRDRYLAvslDIVDEMNQIVLEILSLSSVQ 295
Cdd:COG3290 176 LERLEEE---LEGVKelAEALRAQRHDFRNHLHTISGLLQL-----GEYDEALEYID---EISEELQELIDSLLSRIGNP 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 296 ELAGdkewiqldqvleqILDQYKVLAQSR----ALTIDNQIPDKAVymDPAILKLVLSNVISNAVKHSDAGG------EI 365
Cdd:COG3290 245 VLAA-------------LLLGKAARARERgidlTIDIDSDLPDLPL--SDTDLVTILGNLLDNAIEAVEKLPeeerrvEL 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 366 QLRLEEEGTHLAVENTSQEMVE-----IAEMPMTaSRQKKEGGLGLFVVQHLLDHeelaYQ-----FDKTAMGLRFRMEL 435
Cdd:COG3290 310 SIRDDGDELVIEVEDSGPGIPEellekIFERGFS-TKLGEGRGLGLALVKQIVEK----YGgtievESEEGEGTVFTVRL 384
|
....*
gi 1514708724 436 PKDPQ 440
Cdd:COG3290 385 PKEGE 389
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
332-412 |
6.32e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 39.42 E-value: 6.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 332 IPDKAVY--MDPAILKLVLSNVISNAVKHSDAGGEIQLRLEEEGTHLA---------VENTSQEMV--EIAEMPMTASRQ 398
Cdd:cd16947 7 IPDRPIYanANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYidiwdkgkgISETEKDHVfeRLYTLEDSRNSA 86
|
90
....*....|....
gi 1514708724 399 KKEGGLGLFVVQHL 412
Cdd:cd16947 87 KQGNGLGLTITKRL 100
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
344-414 |
6.32e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 39.19 E-value: 6.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 344 LKLVLSNVISNAVKHSDAGGEIQLRLEEEGTH--LAVENT-----SQEMVEIAEMPMTAS---RQKKEGGLGLFVVQHLL 413
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGvvLSIKDFgigipEEDLPRVFDKGFTGEngrNFQESTGMGLYLVKKLC 85
|
.
gi 1514708724 414 D 414
Cdd:cd16948 86 D 86
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
148-406 |
1.90e-03 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 40.44 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 148 LLASFVLSLIASYLYA-----RMIsapILEIKQMTKRMKRL---DRTANLPIHSQDEIG-------VLKQQINDLYHHLL 212
Cdd:COG4192 328 LLAIALLSLLLAVLINyfyvrRRL---VKRLNALSDAMAAIaagDLDVPIPVDGNDEIGriarllrVFRDQAIEKTQELE 404
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 213 EVIdnlEQQKQENLKLEQMKVEFLRGA------------SHELKTPLASLKIIL--ENMRDKIGRYKDRDRYLAVSLDIV 278
Cdd:COG4192 405 TEI---EERKRIEKNLRQTQDELIQAAkmavvgqtmtslAHELNQPLNAMSMYLfsAKKALEQENYAQLPTSLDKIEGLI 481
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1514708724 279 DEMNQIVLEILSLSsvQELAGDKEWIQLDQVLEQILDQYKVLAQSRALTIdNQIPDKAVYMDPAILKLVLSNVISNAVKH 358
Cdd:COG4192 482 ERMDKIIKSLRQFS--RKSDTPLQPVDLRQVIEQAWELVESRAKPQQITL-HIPDDLMVQGDQVLLEQVLVNLLVNALDA 558
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1514708724 359 SDAGGEIQLRLEEEGTHLAVENT-SQEMVEIAEMPMTASRQKKEGGLGL 406
Cdd:COG4192 559 VATQPQISVDLLSNAENLRVAISdNGNGWPLVDKLFTPFTTTKEVGLGL 607
|
|
| |
