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Conserved domains on  [gi|1524006614|ref|WP_124062131|]
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IS30 family transposase, partial [Escherichia coli]

Protein Classification

transposase( domain architecture ID 11458135)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0043565|GO:0015074|GO:0006313|GO:0003677|GO:0004803
PubMed:  15469518

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tra8 COG2826
Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];
1-83 3.69e-37

Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];


:

Pssm-ID: 442074 [Multi-domain]  Cd Length: 325  Bit Score: 126.15  E-value: 3.69e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524006614   1 GHWEGDLVSGTKN-SHIATLVDRKSRYTIILRLRGKDSVSVNQALTDKFLSLPSELRKSLTWDRGMELARHLEFTVSTGV 79
Cdd:COG2826   173 GHWEGDLIIGKRGkSALLTLVERKSRFVILLKLPDKTAESVADALIRLLRKLPAFLRKSITTDNGKEFADHKEIEAALGI 252


                  ....
gi 1524006614  80 KVYF 83
Cdd:COG2826   253 KVYF 256
 
Name Accession Description Interval E-value
Tra8 COG2826
Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];
1-83 3.69e-37

Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];


Pssm-ID: 442074 [Multi-domain]  Cd Length: 325  Bit Score: 126.15  E-value: 3.69e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524006614   1 GHWEGDLVSGTKN-SHIATLVDRKSRYTIILRLRGKDSVSVNQALTDKFLSLPSELRKSLTWDRGMELARHLEFTVSTGV 79
Cdd:COG2826   173 GHWEGDLIIGKRGkSALLTLVERKSRFVILLKLPDKTAESVADALIRLLRKLPAFLRKSITTDNGKEFADHKEIEAALGI 252


                  ....
gi 1524006614  80 KVYF 83
Cdd:COG2826   253 KVYF 256
transpos_IS30 NF033563
IS30 family transposase;
1-83 3.26e-31

IS30 family transposase;


Pssm-ID: 468088 [Multi-domain]  Cd Length: 267  Bit Score: 109.61  E-value: 3.26e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524006614   1 GHWEGDLVSGTKN-SHIATLVDRKSRYTIILRLRGKDSVSVNQALTDKFLSLPSELRKSLTWDRGMELARHLEFTVSTGV 79
Cdd:NF033563  134 GHWEGDTILGKKHkSALLTLVERKSRFVILVKLPDKTAESVNKALIKLLKPLPKHLRKSITADNGKEFARHSEIEEALGI 213


                  ....
gi 1524006614  80 KVYF 83
Cdd:NF033563  214 DVYF 217
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 1-83 4.29e-11

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 4.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524006614  1 GHWEGDLV-----SGTKNSHIATLVDRKSRYTIILRLRGKDSVSVNQALTDKFLSLPSELRKSLTWDRGMELA--RHLEF 73
Cdd:pfam00665  3 QLWQGDFTyiripGGGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFRGGVPLIIHSDNGSEYTskAFREF 82

                         90
                 ....*....|
gi 1524006614 74 TVSTGVKVYF 83
Cdd:pfam00665 83 LKDLGIKPSF 92
 
Name Accession Description Interval E-value
Tra8 COG2826
Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];
1-83 3.69e-37

Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];


Pssm-ID: 442074 [Multi-domain]  Cd Length: 325  Bit Score: 126.15  E-value: 3.69e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524006614   1 GHWEGDLVSGTKN-SHIATLVDRKSRYTIILRLRGKDSVSVNQALTDKFLSLPSELRKSLTWDRGMELARHLEFTVSTGV 79
Cdd:COG2826   173 GHWEGDLIIGKRGkSALLTLVERKSRFVILLKLPDKTAESVADALIRLLRKLPAFLRKSITTDNGKEFADHKEIEAALGI 252


                  ....
gi 1524006614  80 KVYF 83
Cdd:COG2826   253 KVYF 256
transpos_IS30 NF033563
IS30 family transposase;
1-83 3.26e-31

IS30 family transposase;


Pssm-ID: 468088 [Multi-domain]  Cd Length: 267  Bit Score: 109.61  E-value: 3.26e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524006614   1 GHWEGDLVSGTKN-SHIATLVDRKSRYTIILRLRGKDSVSVNQALTDKFLSLPSELRKSLTWDRGMELARHLEFTVSTGV 79
Cdd:NF033563  134 GHWEGDTILGKKHkSALLTLVERKSRFVILVKLPDKTAESVNKALIKLLKPLPKHLRKSITADNGKEFARHSEIEEALGI 213


                  ....
gi 1524006614  80 KVYF 83
Cdd:NF033563  214 DVYF 217
rve pfam00665
Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into ...
 1-83 4.29e-11

Integrase core domain; Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain pfam02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain pfam00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyzes the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site.


Pssm-ID: 459897 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 4.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524006614  1 GHWEGDLV-----SGTKNSHIATLVDRKSRYTIILRLRGKDSVSVNQALTDKFLSLPSELRKSLTWDRGMELA--RHLEF 73
Cdd:pfam00665  3 QLWQGDFTyiripGGGGKLYLLVIVDDFSREILAWALSSEMDAELVLDALERAIAFRGGVPLIIHSDNGSEYTskAFREF 82

                         90
                 ....*....|
gi 1524006614 74 TVSTGVKVYF 83
Cdd:pfam00665 83 LKDLGIKPSF 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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