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Conserved domains on  [gi|1524783446|ref|WP_124278938|]
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MULTISPECIES: DeoR/GlpR family DNA-binding transcription regulator [Streptomyces]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-253 2.35e-102

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


:

Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 297.82  E-value: 2.35e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446   1 MYAPERQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGAIPAGRLGFEPDLAERDTVAADEKD 80
Cdd:COG1349     1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  81 RIAAAALGELPAQGNIIIDAGTTTVRLAAAVPIDSSLTVVTHALPVAARLSDHPGIALHLVGGRVRHRTRAAVDAWALSA 160
Cdd:COG1349    81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446 161 YAEINADVVFLATNGFSPDGGLTTPDLAEAAVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITDTGLSPEDA 240
Cdd:COG1349   161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                         250
                  ....*....|...
gi 1524783446 241 RAIESLGTEVVRA 253
Cdd:COG1349   241 EALEEAGVEVIVA 253
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-253 2.35e-102

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 297.82  E-value: 2.35e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446   1 MYAPERQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGAIPAGRLGFEPDLAERDTVAADEKD 80
Cdd:COG1349     1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  81 RIAAAALGELPAQGNIIIDAGTTTVRLAAAVPIDSSLTVVTHALPVAARLSDHPGIALHLVGGRVRHRTRAAVDAWALSA 160
Cdd:COG1349    81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446 161 YAEINADVVFLATNGFSPDGGLTTPDLAEAAVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITDTGLSPEDA 240
Cdd:COG1349   161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                         250
                  ....*....|...
gi 1524783446 241 RAIESLGTEVVRA 253
Cdd:COG1349   241 EALEEAGVEVIVA 253
TranRegGlpR_Halo NF041397
HTH-type transcriptional regulator GlpR;
1-251 3.10e-66

HTH-type transcriptional regulator GlpR;


Pssm-ID: 469288 [Multi-domain]  Cd Length: 253  Bit Score: 205.91  E-value: 3.10e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446   1 MYAPERQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGAIPAGRLGFEPDLAERDTVAADEKD 80
Cdd:NF041397    1 MLPEERKRKIVELVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGGAVPVTSVGRERSYGQREVQNLEAKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  81 RIAAAALGELpAQGNIII-DAGTTTVRLAAAVPIDSSLTVVTHALPVAARLSDHpGIALHLVGGRVRHRTRAAVDAWALS 159
Cdd:NF041397   81 AIAERAVEEI-HDGQVVFfDAGTTTMEVAKRVPTDGSFLAVTNSPLLALELAER-DGEVKLTGGTLRPRTRALVGPTAES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446 160 AYAEINADVVFLATNGFSPDGGLTTPDLAEAAVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITDTGLSPED 239
Cdd:NF041397  159 FMERTNFDLLFLGTNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVDLFVTDGALPEEL 238

                         250
                  ....*....|..
gi 1524783446 240 ARAIESLGTEVV 251
Cdd:NF041397  239 REAFEEAGVEVV 250
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 76-233 2.05e-59

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 185.41  E-value: 2.05e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  76 ADEKDRIAAAALGELPAQGNIIIDAGTTTVRLAAAVPIDSSLTVVTHALPVAARLSDHPGIALHLVGGRVRHRTRAAVDA 155
Cdd:pfam00455   3 AEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFVGP 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1524783446 156 WALSAYAEINADVVFLATNGFSPDGGLTTPDLAEAAVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITDT 233
Cdd:pfam00455  83 LAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
srlR PRK10434
DNA-binding transcriptional repressor;
1-251 6.89e-37

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 130.58  E-value: 6.89e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446   1 MYAPERQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGAIpAGRLGFEPDLAERDTVAADEKD 80
Cdd:PRK10434    1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVV-LNKEESDPPIDHKTLINTHKKE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  81 RIAAAALgELPAQGN-IIIDAGTTTVRLAAAVPIDSSLTVVTHALPVAARLSDHPG-IALHLVGGRVRHRTRAAVDAWAL 158
Cdd:PRK10434   80 LIAEAAV-SLIHDGDsIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNeQTILMPGGTFRKKSASFHGQLAE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446 159 SAYAEINADVVFLATNGFSPDGGLTTpdLAEA-AVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITDTGLSP 237
Cdd:PRK10434  159 NAFEHFTFDKLFIGTDGIDLNAGVTT--FNEVyTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDP 236

                         250
                  ....*....|....
gi 1524783446 238 EDARAIESLGTEVV 251
Cdd:PRK10434  237 AFRQALEEKGIEVI 250
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-57 2.45e-11

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 57.23  E-value: 2.45e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1524783446    6 RQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGAI 57
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-253 2.35e-102

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 297.82  E-value: 2.35e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446   1 MYAPERQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGAIPAGRLGFEPDLAERDTVAADEKD 80
Cdd:COG1349     1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  81 RIAAAALGELPAQGNIIIDAGTTTVRLAAAVPIDSSLTVVTHALPVAARLSDHPGIALHLVGGRVRHRTRAAVDAWALSA 160
Cdd:COG1349    81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446 161 YAEINADVVFLATNGFSPDGGLTTPDLAEAAVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITDTGLSPEDA 240
Cdd:COG1349   161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240

                         250
                  ....*....|...
gi 1524783446 241 RAIESLGTEVVRA 253
Cdd:COG1349   241 EALEEAGVEVIVA 253
TranRegGlpR_Halo NF041397
HTH-type transcriptional regulator GlpR;
1-251 3.10e-66

HTH-type transcriptional regulator GlpR;


Pssm-ID: 469288 [Multi-domain]  Cd Length: 253  Bit Score: 205.91  E-value: 3.10e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446   1 MYAPERQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGAIPAGRLGFEPDLAERDTVAADEKD 80
Cdd:NF041397    1 MLPEERKRKIVELVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGGAVPVTSVGRERSYGQREVQNLEAKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  81 RIAAAALGELpAQGNIII-DAGTTTVRLAAAVPIDSSLTVVTHALPVAARLSDHpGIALHLVGGRVRHRTRAAVDAWALS 159
Cdd:NF041397   81 AIAERAVEEI-HDGQVVFfDAGTTTMEVAKRVPTDGSFLAVTNSPLLALELAER-DGEVKLTGGTLRPRTRALVGPTAES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446 160 AYAEINADVVFLATNGFSPDGGLTTPDLAEAAVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITDTGLSPED 239
Cdd:NF041397  159 FMERTNFDLLFLGTNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVDLFVTDGALPEEL 238

                         250
                  ....*....|..
gi 1524783446 240 ARAIESLGTEVV 251
Cdd:NF041397  239 REAFEEAGVEVV 250
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 76-233 2.05e-59

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 185.41  E-value: 2.05e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  76 ADEKDRIAAAALGELPAQGNIIIDAGTTTVRLAAAVPIDSSLTVVTHALPVAARLSDHPGIALHLVGGRVRHRTRAAVDA 155
Cdd:pfam00455   3 AEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFVGP 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1524783446 156 WALSAYAEINADVVFLATNGFSPDGGLTTPDLAEAAVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITDT 233
Cdd:pfam00455  83 LAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
srlR PRK10434
DNA-binding transcriptional repressor;
1-251 6.89e-37

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 130.58  E-value: 6.89e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446   1 MYAPERQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGAIpAGRLGFEPDLAERDTVAADEKD 80
Cdd:PRK10434    1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVV-LNKEESDPPIDHKTLINTHKKE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  81 RIAAAALgELPAQGN-IIIDAGTTTVRLAAAVPIDSSLTVVTHALPVAARLSDHPG-IALHLVGGRVRHRTRAAVDAWAL 158
Cdd:PRK10434   80 LIAEAAV-SLIHDGDsIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNeQTILMPGGTFRKKSASFHGQLAE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446 159 SAYAEINADVVFLATNGFSPDGGLTTpdLAEA-AVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITDTGLSP 237
Cdd:PRK10434  159 NAFEHFTFDKLFIGTDGIDLNAGVTT--FNEVyTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDP 236

                         250
                  ....*....|....
gi 1524783446 238 EDARAIESLGTEVV 251
Cdd:PRK10434  237 AFRQALEEKGIEVI 250
PRK09802 PRK09802
DeoR family transcriptional regulator;
5-251 6.80e-35

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 125.74  E-value: 6.80e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446   5 ERQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGAI--PAGRLGFEPDLAERDTVAADEKDRI 82
Cdd:PRK09802   17 ERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALicDSTTPSVEPSVEDKSALNTAMKRSV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  83 AAAALGELPAQGNIIIDAGTTTVRLAAAVPIDSSLTVVTHALPVAARLSDHPGIALHLVGGRVRHRTRAAVDAWALSAYA 162
Cdd:PRK09802   97 AKAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQAEQSLQ 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446 163 EINADVVFLATNGFSPDGGLTTPDLAEAAVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITDTGLSPEDARA 242
Cdd:PRK09802  177 NYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPADSLEG 256


                  ....*....
gi 1524783446 243 IESLGTEVV 251
Cdd:PRK09802  257 LRKAGVEVI 265
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
1-244 8.01e-29

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 109.56  E-value: 8.01e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446   1 MYAPERQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGA-IPAGRLgfEPDLAERDTVAADEK 79
Cdd:PRK10906    1 MKQTQRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAaLPSSSV--NTPWHDRKATQTEEK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  80 DRIAAAALGELPAQGNIIIDAGTTTVRLAAAVPIDSSLTVVTHALPVAARLSDHPGIALHLVGGRVRHRTRAAVDAWALS 159
Cdd:PRK10906   79 ERIARKVASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATLD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446 160 AYAEINADVVFLATNGFSPDGGLTTPDLAEAAVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITDTGLSPED 239
Cdd:PRK10906  159 FISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQLPPASV 238


                  ....*
gi 1524783446 240 ARAIE 244
Cdd:PRK10906  239 MQVIE 243
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
1-253 1.55e-26

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 103.16  E-value: 1.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446   1 MYAPERQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGA--IPAGRLGFEPdLAERDTVAADE 78
Cdd:PRK13509    1 MTEAQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGAeaITQQRPRWTP-MNIHQAQNHDE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  79 KDRIAAAAlGELPAQGN-IIIDAGTTTVRLAAAVpIDSSLTVVTHALPVAARLSDHPGIALHLVGGRVrHRTRA---AVD 154
Cdd:PRK13509   80 KVRIAKAA-SQLCNPGEsVVINCGSTAFLLGREL-CGKPVQIITNYLPLANYLIDQEHDSVIIMGGQY-NKSQSitlSPQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446 155 AWALSAYAeinADVVFLATNGFSPDGgLTTPDLAEAAVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITDTG 234
Cdd:PRK13509  157 GSENSLYA---GHWMFTSGKGLTADG-LYKTDMLTAMAEQKMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKN 232

                         250
                  ....*....|....*....
gi 1524783446 235 LSPEDARAIESLGTEVVRA 253
Cdd:PRK13509  233 ADPEVLQQLEAQGVSILLV 251
PRK10411 PRK10411
L-fucose operon activator;
5-232 4.32e-21

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 88.71  E-value: 4.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446   5 ERQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGA---IPAGRLGFEPDLAERDTVAADEKDr 81
Cdd:PRK10411    4 ARQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAkyiHRQNQDSGDPFHIRLKSHYAHKAD- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  82 IAAAALGELPAQGNIIIDAGTTTVRLAAAVPiDSSLTVVTHALPVAARLSDHPGIALHLVGGRVRHRTRAAVDAWALSAY 161
Cdd:PRK10411   83 IAREALAWIEEGMVIALDASSTCWYLARQLP-DINIQVFTNSHPICQELGKRERIQLISSGGTLERKYGCYVNPSLISQL 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1524783446 162 AEINADVVFLATNGFSPDGGLTTPDLAEAAVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITD 232
Cdd:PRK10411  162 KSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISD 232
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 6-232 4.55e-17

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 77.81  E-value: 4.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446   6 RQQEILRIAGESGRVDVLSLAEQFQ---VTAETVRRDLKALDRAGLLRrvhGGAIPAgrlgfEPD------LAERDTVAA 76
Cdd:PRK10681    5 RDERIGQLLQALKRSDKLHLKDAAAllgVSEMTIRRDLNAHSAPVVLL---GGYIVL-----EPRsashylLSDQKSRLV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  77 DEKDRIAAAALGELPAQGNIIIDAGTTTVRLAAAVPIDSSLTVVTHALPVAARLSDHPGIALHLVGGRVrHRTRAAVDAw 156
Cdd:PRK10681   77 EEKRRAAQLAATLVEPNQTLFFDCGTTTPWIIEAIDNELPFTAVCYSLNTFLALQEKPHCRAILCGGEF-HASNAIFKP- 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1524783446 157 aLSAYAEIN---ADVVFLATNGFSPDGGLTTPDLAEAAVKRAVIAAARRVVLLADSGKSGQEHFARFGDLSHVDLLITD 232
Cdd:PRK10681  155 -LDFQQTLDnicPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMAMAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSD 232
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-57 2.45e-11

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 57.23  E-value: 2.45e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1524783446    6 RQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGAI 57
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
6-57 3.17e-10

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 54.57  E-value: 3.17e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1524783446   6 RQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGAI 57
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAV 52
COG3177 COG3177
Fic family protein [Transcription];
5-55 6.33e-04

Fic family protein [Transcription];


Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 40.44  E-value: 6.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1524783446   5 ERQQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGG 55
Cdd:COG3177   261 ERQRKLLELLFENPVLTASELAELLGVSRRTARRDLKDLVELGILEKVGGG 311
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
10-72 1.13e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 38.26  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524783446  10 ILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVHGGAI---PAGR--------------------LGFEP 66
Cdd:COG1321    15 IYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGItltEEGRelalrivrrhrllerflvevLGVDW 94


                  ....*.
gi 1524783446  67 DLAERD 72
Cdd:COG1321    95 DEAHEE 100
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
7-53 3.82e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 36.03  E-value: 3.82e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1524783446    7 QQEILRIAGESGRVDVLSLAEQFQVTAETVRRDLKALDRAGLLRRVH 53
Cdd:smart00347  12 QFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREP 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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