|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-466 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 721.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 1 MSRATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFEN 80
Cdd:PRK05826 2 MLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 81 GKIELVNGRPFILDADRTELGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAAVHTIVKMGGELSNNKGINK 160
Cdd:PRK05826 82 GKITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 161 QGGGLTAPALTGKDMEDIKTAMSFQCEYLAVSFPKNATDMEMARQLANVAGEPyrhKPGMIAKIERYEAIPHLEAILKAS 240
Cdd:PRK05826 162 PGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCP---HAKIIAKIERAEAVDNIDEIIEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 241 DGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETAA 320
Cdd:PRK05826 239 DGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 321 GKFPVETIEQMAAIALEAERAEFVTLDTDFAGRQFARIDQSIAMGALFTAHHL-GCKAILALTESGSTALWMSRHRIQVP 399
Cdd:PRK05826 319 GKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLkGVKAIVALTESGRTARLISRFRPGAP 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1525829459 400 IFALTTTAVSQRKMSLYRNVRPLLMPKYEDRDTALAAAEQILVDMGVLMPGDTYAITCGEPMGYPGG 466
Cdd:PRK05826 399 IFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAGG 465
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-475 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 681.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 1 MSRATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFEN 80
Cdd:COG0469 1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 81 GKIELVNGRPFILDADRTElGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAAVHTIVKMGGELSNNKGINK 160
Cdd:COG0469 81 GPVELKKGDTFTLTTDDVE-GDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 161 QGGGLTAPALTGKDMEDIKTAMSFQCEYLAVSFPKNATDMEMARQLANVAGEpyrhKPGMIAKIERYEAIPHLEAILKAS 240
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG----RAPIIAKIEKPEAVENLDEIIEAS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 241 DGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETAA 320
Cdd:COG0469 236 DGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 321 GKFPVETIEQMAAIALEAERAEFVTLDTDF-AGRQFARIDQSIAMGALFTAHHLGCKAILALTESGSTALWMSRHRIQVP 399
Cdd:COG0469 316 GKYPVEAVETMARIAEEAEKSLDYRRILDRlRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVP 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1525829459 400 IFALTTTAVSQRKMSLYRNVRPLLMPKYEDRDTALAAAEQILVDMGVLMPGDTYAITCGEPMGYPGGTNMLKVCRV 475
Cdd:COG0469 396 ILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
3-472 |
5.37e-171 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 489.48 E-value: 5.37e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 3 RATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFENGK 82
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 83 IELVNGRPFILDAD-RTELGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAAVHTIVKMGGELSNNKGINKQ 161
Cdd:TIGR01064 81 VKLKKGDKVIITTDdIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 162 GGGLTAPALTGKDMEDIKTAMSFQCEYLAVSFPKNATDMEMARQLANVAGEPYRHkpgMIAKIERYEAIPHLEAILKASD 241
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVK---IIAKIENQEGVDNIDEIAEASD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 242 GIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETAAG 321
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 322 KFPVETIEQMAAIALEAERAEFVTL---DTDFAGRQFARIDQSIAMGALFTAHHLGCKAILALTESGSTALWMSRHRIQV 398
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTnfnDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNA 397
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1525829459 399 PIFALTTTAVSQRKMSLYRNVRPLLMPKY-EDRDTALAAAEQILVDMGVLMPGDTYAITCGEPMGYPGGTNMLKV 472
Cdd:TIGR01064 398 PIIAVTPNERVARQLALYWGVFPFLVDEEpSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
3-475 |
2.93e-160 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 462.55 E-value: 2.93e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 3 RATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFENG- 81
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 82 KIELVNGRPFILDADRTEL-GNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAA-VHTIVKMGGELSNNKGIN 159
Cdd:cd00288 82 DISLKAGDKFLVTTDPAAKkGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGVN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 160 KQGGGLTAPALTGKDMEDIKTAMSFQCEYLAVSFPKNATDMEMARQLANVAGEPYRhkpgMIAKIERYEAIPHLEAILKA 239
Cdd:cd00288 162 LPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIK----IIAKIENQEGVNNFDEILEA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 240 SDGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETA 319
Cdd:cd00288 238 SDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 320 AGKFPVETIEQMAAIALEAERA--EFVTLDT-DFAGRQFARIDQSIAMGALFTAHHLGCKAILALTESGSTALWMSRHRI 396
Cdd:cd00288 318 KGKYPVEAVKAMARICLEAEKAlsHRVLFNEmRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRP 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 397 QVPIFALTTTAVSQRKMSLYRNVRPLLMPK-----YEDRDTALAAAEQILVDMGVLMPGDTYAITCGEPMGyPGGTNMLK 471
Cdd:cd00288 398 NAPIIAVTRNEQTARQLHLYRGVYPVLFEEpkpgwQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMR 476
|
....
gi 1525829459 472 VCRV 475
Cdd:cd00288 477 ILTV 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
3-341 |
1.42e-120 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 356.29 E-value: 1.42e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 3 RATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFENGK 82
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 83 --IELVNGRPFI--LDADRTELGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAA-VHTIVKMGGELSNNKG 157
Cdd:pfam00224 82 kdIELKAGDEMIvsTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRKG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 158 INKQGGGLTAPALTGKDMEDIKTAMSFQCEYLAVSFPKNATDMEMARQLANVAGepyrHKPGMIAKIERYEAIPHLEAIL 237
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG----KNIQIIAKIENQEGVNNFDEIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 238 KASDGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAE 317
Cdd:pfam00224 238 EATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGE 317
|
330 340
....*....|....*....|....
gi 1525829459 318 TAAGKFPVETIEQMAAIALEAERA 341
Cdd:pfam00224 318 TAKGNYPVEAVRMMHEICLEAEKA 341
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
1-466 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 721.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 1 MSRATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFEN 80
Cdd:PRK05826 2 MLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 81 GKIELVNGRPFILDADRTELGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAAVHTIVKMGGELSNNKGINK 160
Cdd:PRK05826 82 GKITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGINI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 161 QGGGLTAPALTGKDMEDIKTAMSFQCEYLAVSFPKNATDMEMARQLANVAGEPyrhKPGMIAKIERYEAIPHLEAILKAS 240
Cdd:PRK05826 162 PGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCP---HAKIIAKIERAEAVDNIDEIIEAS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 241 DGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETAA 320
Cdd:PRK05826 239 DGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 321 GKFPVETIEQMAAIALEAERAEFVTLDTDFAGRQFARIDQSIAMGALFTAHHL-GCKAILALTESGSTALWMSRHRIQVP 399
Cdd:PRK05826 319 GKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLkGVKAIVALTESGRTARLISRFRPGAP 398
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1525829459 400 IFALTTTAVSQRKMSLYRNVRPLLMPKYEDRDTALAAAEQILVDMGVLMPGDTYAITCGEPMGYPGG 466
Cdd:PRK05826 399 IFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAGG 465
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
1-475 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 681.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 1 MSRATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFEN 80
Cdd:COG0469 1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 81 GKIELVNGRPFILDADRTElGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAAVHTIVKMGGELSNNKGINK 160
Cdd:COG0469 81 GPVELKKGDTFTLTTDDVE-GDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 161 QGGGLTAPALTGKDMEDIKTAMSFQCEYLAVSFPKNATDMEMARQLANVAGEpyrhKPGMIAKIERYEAIPHLEAILKAS 240
Cdd:COG0469 160 PGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGG----RAPIIAKIEKPEAVENLDEIIEAS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 241 DGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETAA 320
Cdd:COG0469 236 DGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 321 GKFPVETIEQMAAIALEAERAEFVTLDTDF-AGRQFARIDQSIAMGALFTAHHLGCKAILALTESGSTALWMSRHRIQVP 399
Cdd:COG0469 316 GKYPVEAVETMARIAEEAEKSLDYRRILDRlRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVP 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1525829459 400 IFALTTTAVSQRKMSLYRNVRPLLMPKYEDRDTALAAAEQILVDMGVLMPGDTYAITCGEPMGYPGGTNMLKVCRV 475
Cdd:COG0469 396 ILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
3-472 |
5.37e-171 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 489.48 E-value: 5.37e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 3 RATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFENGK 82
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 83 IELVNGRPFILDAD-RTELGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAAVHTIVKMGGELSNNKGINKQ 161
Cdd:TIGR01064 81 VKLKKGDKVIITTDdIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 162 GGGLTAPALTGKDMEDIKTAMSFQCEYLAVSFPKNATDMEMARQLANVAGEPYRHkpgMIAKIERYEAIPHLEAILKASD 241
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVK---IIAKIENQEGVDNIDEIAEASD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 242 GIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETAAG 321
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 322 KFPVETIEQMAAIALEAERAEFVTL---DTDFAGRQFARIDQSIAMGALFTAHHLGCKAILALTESGSTALWMSRHRIQV 398
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAYLTnfnDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNA 397
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1525829459 399 PIFALTTTAVSQRKMSLYRNVRPLLMPKY-EDRDTALAAAEQILVDMGVLMPGDTYAITCGEPMGYPGGTNMLKV 472
Cdd:TIGR01064 398 PIIAVTPNERVARQLALYWGVFPFLVDEEpSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
3-475 |
2.93e-160 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 462.55 E-value: 2.93e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 3 RATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFENG- 81
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 82 KIELVNGRPFILDADRTEL-GNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAA-VHTIVKMGGELSNNKGIN 159
Cdd:cd00288 82 DISLKAGDKFLVTTDPAAKkGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGVN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 160 KQGGGLTAPALTGKDMEDIKTAMSFQCEYLAVSFPKNATDMEMARQLANVAGEPYRhkpgMIAKIERYEAIPHLEAILKA 239
Cdd:cd00288 162 LPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIK----IIAKIENQEGVNNFDEILEA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 240 SDGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETA 319
Cdd:cd00288 238 SDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 320 AGKFPVETIEQMAAIALEAERA--EFVTLDT-DFAGRQFARIDQSIAMGALFTAHHLGCKAILALTESGSTALWMSRHRI 396
Cdd:cd00288 318 KGKYPVEAVKAMARICLEAEKAlsHRVLFNEmRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRP 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 397 QVPIFALTTTAVSQRKMSLYRNVRPLLMPK-----YEDRDTALAAAEQILVDMGVLMPGDTYAITCGEPMGyPGGTNMLK 471
Cdd:cd00288 398 NAPIIAVTRNEQTARQLHLYRGVYPVLFEEpkpgwQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMR 476
|
....
gi 1525829459 472 VCRV 475
Cdd:cd00288 477 ILTV 480
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
1-476 |
1.34e-152 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 442.83 E-value: 1.34e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 1 MSRATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFEN 80
Cdd:PRK06247 3 RNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFAD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 81 GKIELVNGRPFILDADRTElGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAAVHTIVKMGGELSNNKGINK 160
Cdd:PRK06247 83 GKVQLANGQTFRLDVDDAP-GDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 161 QGGGLTAPALTGKDMEDIKTAMSFQCEYLAVSFPKNATDMEMARQLAnvagepyRHKPGMIAKIERYEAIPHLEAILKAS 240
Cdd:PRK06247 162 PGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKII-------GGRVPVMAKIEKPQAIDRLEAIVEAS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 241 DGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETAA 320
Cdd:PRK06247 235 DAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETAS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 321 GKFPVETIEQMAAIALEAERaefvtlDTDF-----AGRQFARIDQS--IAMGALFTAHHLGCKAILALTESGSTALWMSR 393
Cdd:PRK06247 315 GKYPVEAVRTMARIIRQVER------DPTYpplihAQRPQPEATKRdaISYAARDIAERLDLAALVAYTSSGDTALRAAR 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 394 HRIQVPIFALTTTAVSQRKMSLYRNVRPLLMPKYEDRDTALAAAEQILVDMGVLMPGDTYAITCGEPMGYPGGTNMLKVC 473
Cdd:PRK06247 389 ERPPLPILALTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIA 468
|
...
gi 1525829459 474 RVG 476
Cdd:PRK06247 469 YIG 471
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-476 |
6.07e-146 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 429.73 E-value: 6.07e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 1 MSRATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFEN 80
Cdd:PRK06354 6 LMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFED 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 81 GKIELVNGRPFILDADRTElGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAA--VHTIVKMGGELSNNKGI 158
Cdd:PRK06354 86 GPIELKTGDEFILTSREVL-GTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLHCKVLVGGVLSNKKGV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 159 NKQGGGLTAPALTGKDMEDIKTAMSFQCEYLAVSFPKNATDMEMARQL--ANVAgepyRHKPgMIAKIERYEAIPHLEAI 236
Cdd:PRK06354 165 NFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELieEHNG----KHIP-IIAKIEKQEAIDNIDAI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 237 LKASDGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSA 316
Cdd:PRK06354 240 LELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 317 ETAAGKFPVETIEQMAAIALEAERAEFVTLDTDFAGRQFARIDQSIAMGALFTAHHLGCKAILALTESGSTALWMSRHRI 396
Cdd:PRK06354 320 ETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRP 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 397 QVPIFALTTTAVSQRKMSLYRNVRPLLMPKYEDRDTALAAAEQILVDMGVLMPGDTYAITCGEPMGYPGGTNMLKVCRVG 476
Cdd:PRK06354 400 KTPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVG 479
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
3-341 |
1.42e-120 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 356.29 E-value: 1.42e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 3 RATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFENGK 82
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 83 --IELVNGRPFI--LDADRTELGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAA-VHTIVKMGGELSNNKG 157
Cdd:pfam00224 82 kdIELKAGDEMIvsTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSRKG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 158 INKQGGGLTAPALTGKDMEDIKTAMSFQCEYLAVSFPKNATDMEMARQLANVAGepyrHKPGMIAKIERYEAIPHLEAIL 237
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAG----KNIQIIAKIENQEGVNNFDEIL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 238 KASDGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAE 317
Cdd:pfam00224 238 EATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGE 317
|
330 340
....*....|....*....|....
gi 1525829459 318 TAAGKFPVETIEQMAAIALEAERA 341
Cdd:pfam00224 318 TAKGNYPVEAVRMMHEICLEAEKA 341
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
3-475 |
1.47e-118 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 355.52 E-value: 1.47e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 3 RATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFENGK 82
Cdd:PRK09206 2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGGN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 83 -IELVNGRPFILDADRTELGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAAVHTIVKMGGELSNNKGINKQ 161
Cdd:PRK09206 82 dVSLKAGQTFTFTTDKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNLP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 162 GGGLTAPALTGKDMEDIKtamsFQCE----YLAVSFPKNATDMEMARQLANVAGEPYRHkpgMIAKIERYEAIPHLEAIL 237
Cdd:PRK09206 162 GVSIALPALAEKDKQDLI----FGCEqgvdFVAASFIRKRSDVLEIREHLKAHGGENIQ---IISKIENQEGLNNFDEIL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 238 KASDGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAE 317
Cdd:PRK09206 235 EASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 318 TAAGKFPVETIEQMAAIALEAERAEFVTLDTDFAGRQFaRIDQSIAMGALFTAHHLGCKAILALTESGSTALWMSRHRIQ 397
Cdd:PRK09206 315 SAKGKYPLEAVSIMATICERTDRVMNSRLESNNDNRKL-RITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPD 393
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1525829459 398 VPIFALTTTAVSQRKMSLYRNVRPLLMPKYEDRDTALAAAEQILVDMGVLMPGDTYAITCGePMGYPGGTNMLKVCRV 475
Cdd:PRK09206 394 ATILALTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSG-ALVPSGTTNTASVHVL 470
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
2-475 |
2.03e-108 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 330.96 E-value: 2.03e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 2 SRATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKS-VAIMADLQGPKIRVGKFEN 80
Cdd:PTZ00066 37 QKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARPNAnLGILLDTKGPEIRTGFLKN 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 81 GK-IELVNGRPFILDADRTELGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAAVHTIVKMGGELSNNKGIN 159
Cdd:PTZ00066 117 HKpITLKEGQTLKITTDYTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNMN 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 160 KQGGGLTAPALTGKDMEDI-KTAMSFQCEYLAVSFPKNATDMEMARQLAnvaGEPYRHKPgMIAKIERYEAIPHLEAILK 238
Cdd:PTZ00066 197 LPGVKVELPVIGEKDKNDIlNFAIPMGCDFIALSFVQSADDVRLCRQLL---GERGRHIK-IIPKIENIEGLINFDEILA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 239 ASDGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAET 318
Cdd:PTZ00066 273 ESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGET 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 319 AAGKFPVETIEQMAAIALEAE---------RAEFVTLDTDFAgrqfarIDQSIAMGALFTAHHLGCKAILALTESGSTAL 389
Cdd:PTZ00066 353 ANGKFPVEAVNIMAKICFEAEtcidyrvlyHAIHLAVPTPVS------VQEAVARSAVETAEDINAKLIIALTETGNTAR 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 390 WMSRHRIQVPIFALTTTAVSQRKMSLYRNVRPLLMPKYEDRDTALAAAEQILVDMGVLMPGDTYAITCGEPMGYPGGTNM 469
Cdd:PTZ00066 427 LISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNL 506
|
....*.
gi 1525829459 470 LKVCRV 475
Cdd:PTZ00066 507 MKVVKI 512
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
3-475 |
4.44e-91 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 288.37 E-value: 4.44e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 3 RATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSV-AIMADLQGPKIRVGKFENg 81
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNViAIMLDTKGPEVRSGDLPQ- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 82 KIELVNGRPFILDADRTeLGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAAVHTIVKMGGELSNNKGINKQ 161
Cdd:PLN02623 189 PIMLEEGQEFTFTIKRG-VSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVR 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 162 GGGLTAPALTGKDMEDIKTAMSFQCEYLAVSFPKNATDM-EMARQLANVAGEPYrhkpgMIAKIERYEAIPHLEAILKAS 240
Cdd:PLN02623 268 GKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVhELKDYLKSCNADIH-----VIVKIESADSIPNLHSIITAS 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 241 DGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETAA 320
Cdd:PLN02623 343 DGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAH 422
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 321 GKFPVETIEQMAAIALEAERAEFVTLDTDFAGRQF-ARIDQSIAMGALFTAHHLGcKAILALTESGSTALWMSRHRIQVP 399
Cdd:PLN02623 423 GKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFkNHMSEMFAFHATMMANTLG-TSIIVFTRTGFMAILLSHYRPSGT 501
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1525829459 400 IFALTTTAVSQRKMSLYRNVRPLLMPKYEDRDTALAAAEQILVDMGVLMPGDTYAI--TCGEPMGYPGGTNMLKVCRV 475
Cdd:PLN02623 502 IFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALvqSGRQPIWRSESTHHIQVRKV 579
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
5-451 |
1.07e-88 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 279.94 E-value: 1.07e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 5 TKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFENGK-I 83
Cdd:PLN02461 23 TKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDGKpV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 84 ELVNGRPFILDADRTELGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEA--VRGAAVHTIVKMGGELSNNKGINKQ 161
Cdd:PLN02461 103 QLKQGQEITITTDYSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLScdVEAGTVRCRCENSAMLGERKNVNLP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 162 GGGLTAPALTGKDMEDI-KTAMSFQCEYLAVSFPKNATDMEMARQLANVAGEPYRhkpgMIAKIERYEAIPHLEAILKAS 240
Cdd:PLN02461 183 GVVVDLPTLTEKDKEDIlQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSIL----LISKVENQEGLDNFDDILAES 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 241 DGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETAA 320
Cdd:PLN02461 259 DAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAA 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 321 GKFPVETIEQMAAIALEAERaefvTLDTdfaGRQFARI--DQSIAMG--------ALFTAHHLGCKAILALTESGSTALW 390
Cdd:PLN02461 339 GAYPELAVKTMARICREAEA----SLDY---GALFKEImrSAPLPMSpleslassAVRTANKVKASLIVVLTRGGTTARL 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 391 MSRHRIQVPI------------FALTTTAVSQRKMSL-YRNVRPLLMP---KYEDRDT---ALAAAEQILVDMGVLMPGD 451
Cdd:PLN02461 412 VAKYRPAVPIlsvvvpeittdsFDWSCSDEAPARHSLiYRGLIPVLAEgsaKATDSESteeILEAAIEHAKKKGLCKPGD 491
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
8-351 |
3.06e-84 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 263.34 E-value: 3.06e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 8 VATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAaalaGKSVAIMADLQGPKIRVGKFENGKIELVN 87
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSL----DDSIKILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 88 GRPFILDADRTElGNEDIVGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAAVHTIVKMGGELSNNKGINKQGGGLTA 167
Cdd:PRK06739 82 GDSFILHTQPVT-GSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 168 PALTGKDMEDIKTAMSFQCEYLAVSFPKNATDMemaRQLANVAGEPYRHKPGMIAKIERYEAIPHLEAILKASDGIMVAR 247
Cdd:PRK06739 161 PAITEKDKKDIQFLLEEDVDFIACSFVRKPSHI---KEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIAR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 248 GDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETAAGKFPVET 327
Cdd:PRK06739 238 GDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIES 317
|
330 340
....*....|....*....|....
gi 1525829459 328 IEQMAAIaleAERAEFVTLDTDFA 351
Cdd:PRK06739 318 VSTLRLV---SEFAEHVKKDGPFV 338
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
2-452 |
6.65e-74 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 241.57 E-value: 6.65e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 2 SRATKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVG----- 76
Cdd:PLN02762 24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGdlgga 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 77 ---KFENGKIELVNGRPFilDADRTELgnedIVGLDYKELPRDVKPGDTLLlndgllvltveaVRGAAV--HTIVKMGGE 151
Cdd:PLN02762 104 ssaKAEDGEEWTFTVRKF--DGSRPEF----TIQVNYDGFAEDVKVGDELV------------VDGGMVrfEVIEKIGPD 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 152 LS-------------------NNKGINKQGGGLtaPALTGKDMEDIKTAMSFQCEYLAVSFPKNAtdmEMARQLAN-VAG 211
Cdd:PLN02762 166 VKckctdpglllpranltfwrDGSLVRERNAML--PTISSKDWLDIDFGISEGVDFIAVSFVKSA---EVIKHLKSyIAA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 212 EPYRHKPGMIAKIERYEAIPHLEAILKASDGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITATQMMESMIVNP 291
Cdd:PLN02762 241 RSRDSDIGVIAKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 292 VPTRAEVSDVANAVLDGTDAVMLSAETAAGKFPVETIEQMAAIAL-------EAERAEFVTLdTDFAGRQFARIDQSIAM 364
Cdd:PLN02762 321 TPTRAEVADVSEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLrmelwsrEEKRHEALEL-PQLSSSLSDRISEEICN 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 365 GALFTAHHLGCKAILALTESGSTALWMSRHRIQVPIFALTTTAVSQRKMSLYRNVRPLLMPKYEDRDTALAAAEQILVDM 444
Cdd:PLN02762 400 SAAKMANNLGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKAR 479
|
....*...
gi 1525829459 445 GVLMPGDT 452
Cdd:PLN02762 480 GMIKSGDL 487
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
29-472 |
2.35e-69 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 228.01 E-value: 2.35e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 29 VDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFENGKIELVNGRPFILDADR--TELGNEDIV 106
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPafADKGTKDKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 107 GLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGA-AVHTIVKMGGELSNNKGINKQGGGLTAPALTGKDMEDIKTAMSFQ 185
Cdd:PTZ00300 81 YIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEqTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 186 CEYLAVSFPKNATDMEMARQLANVAGepyrHKPGMIAKIERYEAIPHLEAILKASDGIMVARGDLAVEVGNAAVPALQKR 265
Cdd:PTZ00300 161 VDMIFASFIRSAEQVGEVRKALGAKG----GDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 266 MIKLARELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETAAGKFPVETIEQMAAIALEAERA--EF 343
Cdd:PTZ00300 237 LISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAvnEY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 344 VTLDTDFAGRQFA-RIDQSIAMGALFTAHHLGCKAILALTESGSTALWMSRHRIQVPIFALTTTAVSQRKMSLYRNVRPL 422
Cdd:PTZ00300 317 VFFNSIKKLQPIPmSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESV 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1525829459 423 L-----MPKYEDRDTALAAAEQILVDMGVLMPGDTYAITCGEPM--GYPGGTNMLKV 472
Cdd:PTZ00300 397 FfdaerLGHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKvkGYANQTRIILV 453
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
5-451 |
1.47e-63 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 214.53 E-value: 1.47e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 5 TKIVATLGPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFENGKIE 84
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 85 LVNGRPFILDADRTELGNEDIVGLDYKELPRDVKPGDT--------LLLNDGLLVLTVEAVRGAAVHTIVK----MGGEL 152
Cdd:PLN02765 110 LKAGNTVTLTPDQSKEASSEVLPINFPGLAKAVKPGDTifvgqylfTGSETTSVWLEVDEVKGDDVVCTVKnsatLAGSL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 153 ----SNNKGINkqgggltAPALTGKDMEDIKT-AMSFQCEYLAVSFPKNATDMEMARQLANVAGEPYRHkpgMIAKIERY 227
Cdd:PLN02765 190 ftlhVSQVRID-------LPTLSEKDKEVISTwGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQ---IFAKIENV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 228 EAIPHLEAILKASDGIMVARGDLAVEVGNAAVPALQKRMIKLARELDKVAITaTQMMESMIVNPVPTRAEVSDVANAVLD 307
Cdd:PLN02765 260 EGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLD 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 308 GTDAVMLSAETAAGKFPVETIEQMAAIALEAERaefvTLDTDFagrQFARI----------DQSIAMGALFTAHHLGCKA 377
Cdd:PLN02765 339 GADAILLGAETLRGLYPVETISTVGRICAEAEK----VFNQDL---YFKKTvkyvgepmshLESIASSAVRAAIKVKASV 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 378 ILALTESGSTALWMSRHRIQVPIFALT-------------TTAVSQRKMSLYRNVRPLLMPKYEDRDTALAAAEQIL--- 441
Cdd:PLN02765 412 IIVFTSSGRAARLIAKYRPTMPVLSVViprlktnqlkwsfTGAFQARQCLIVRGLFPMLADPRHSAESTSATNESVLkva 491
|
490
....*....|....
gi 1525829459 442 VD----MGVLMPGD 451
Cdd:PLN02765 492 LDhgkaAGVIKSHD 505
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
275-477 |
7.54e-45 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 159.30 E-value: 7.54e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 275 KVAITATQMMESMIVNPVPTRAEVSDVANAVLDGTDAVMLSAETAAGKFPVETIEQMAAIALEAERAEFVTLDTDFAGRQ 354
Cdd:COG3848 7 KPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQRVPRAKE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 355 FAR-IDQSIAMGALFTAHHLGCKAILALTESGSTALWMSRHRIQVPIFALTTTAVSQRKMSLYRNVRPLLMPKYEDRDTA 433
Cdd:COG3848 87 SSTtITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEESASTDEM 166
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1525829459 434 LAAAEQILVDMGVLMPGDTYAITCGEPMGYPGGTNMLKVCRVGG 477
Cdd:COG3848 167 FAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGD 210
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
360-472 |
7.28e-39 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 136.84 E-value: 7.28e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 360 QSIAMGALFTAHHLGCKAILALTESGSTALWMSRHRIQVPIFALTTTAVSQRKMSLYRNVRPLLMPKYEDRDTALAAAEQ 439
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
|
90 100 110
....*....|....*....|....*....|...
gi 1525829459 440 ILVDMGVLMPGDTYAITCGEPMGYPGGTNMLKV 472
Cdd:pfam02887 81 VAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKV 113
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
2-314 |
7.53e-33 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 130.52 E-value: 7.53e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 2 SRATKIVATL-GPASSSPEILARMIAAGVDVVRLNFSHGKA---QDHIDRaklVREAAALAGKSVAIMADLQGPKIRVGK 77
Cdd:PRK08187 132 ARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPaawQAMIGH---LRQAERATGRRCKILMDLAGPKIRTGA 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 78 F--ENGKIELVNGRPFILDADRTELGNEDI---VGLDYKELPRDVKPGDTLLLNDGLLVLTVEAVRGAAVH---TIVKMG 149
Cdd:PRK08187 209 VagPLGKTRLYTGDRLALVAQGPPRRIDEEhfqVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALlevTHARPK 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 150 GE-LSNNKGINKQGGGLTAPALTGKDMEDiktaMSFQCEY---LAVSFPKNATDMEMARQLANVAGEPYRHKPGMIAKIE 225
Cdd:PRK08187 289 GLkLKPEKGLNFPDTALDLPALTEKDRAD----LDFVARHadlVGYSFVQSPGDVEALQAALAARRPDDWRKLGLVLKIE 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 226 RYEAIPHLEAILKASDG-----IMVARGDLAVEVGNAAVPALQKRMIKLArELDKV-AITATQMMESMIVNPVPTRAEVS 299
Cdd:PRK08187 365 TPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLC-EAAHVpVIWATQVLEGLVKKGLPSRAEMT 443
|
330
....*....|....*
gi 1525829459 300 DVANAvlDGTDAVML 314
Cdd:PRK08187 444 DAAMA--ARAECVML 456
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
2-314 |
1.25e-23 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 104.26 E-value: 1.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 2 SRATKIVATL-GPASSSPEILARMIAAGVDVVRLNFSHGKAQDHIDRAKLVREAAALAGKSVAIMADLQGPKIRVGKFEN 80
Cdd:PRK14725 138 GRPTRIMVTLpTEAADDPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGPIAP 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 81 G---------------------------------------------------------------------KIELVNGRPF 91
Cdd:PRK14725 218 GprviklrptrdalgrvltparlwltasespppspppgpvglpvdpewlarlepgdelrftdargkkrklTVTEVDDEGV 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 92 ILDADRT---------ELGNED---IVGLDYKE------------LPRDVKPGDTLLLNDGLLVLT-------------- 133
Cdd:PRK14725 298 LAEGSQTaylangtllRLGRHDstrVGGLPPVEqklrlkvgdrlvLTRDDAPGDPAQGDAPPARISctlpeafraarvge 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 134 ------------VEAVRGAAVH-TIVKMGGELSN---NKGINKQGGGLTAPALTGKDMEDIKTAMSfQCEYLAVSFPKNA 197
Cdd:PRK14725 378 rvwfddgkigavVVKVEADEVElRITHARPGGSKlkaGKGINLPDSHLPLPALTDKDLEDLAFVAK-HADIVALSFVRSP 456
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1525829459 198 TDME-MARQLANVAGEpyrhKPGMIAKIERYEAIPHLEAIL-----KASDGIMVARGDLAVEVGNAAVPALQKRMIKLAR 271
Cdd:PRK14725 457 EDVRlLLDALEKLGAD----DLGVVLKIETRRAFENLPRILleamrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCE 532
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 1525829459 272 ELDKVAITATQMMESMIVNPVPTRAEVSDVANAVLdgTDAVML 314
Cdd:PRK14725 533 AAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVML 573
|
|
| |
