|
Name |
Accession |
Description |
Interval |
E-value |
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
45-475 |
1.51e-77 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 255.78 E-value: 1.51e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 45 DINVLRTEMFlDAERELFENiNENIYFLEAPTGSGKSNTAFNLSFKLFEgDKNLKKIYYVYPFNALVEQNLNVLNNTFEn 124
Cdd:COG1203 127 PINPLQNEAL-ELALEAAEE-EPGLFILTAPTGGGKTEAALLFALRLAA-KHGGRRIIYALPFTSIINQTYDRLRDLFG- 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 125 neavsDKIAVINSiypikedkkyieyDSKENINNGKNEKDYGHEYYeraLLNRQFLNYPVILTTHVSLFNIMFGDKKEDT 204
Cdd:COG1203 203 -----EDVLLHHS-------------LADLDLLEEEEEYESEARWL---KLLKELWDAPVVVTTIDQLFESLFSNRKGQE 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 205 FSFHQLANSVIVLDEIQSYKNTIWTEIISFLKgFAKILNIKVIIMSATLPDLNMLAVNKSN--VCNLIKNREKYFSNLKf 282
Cdd:COG1203 262 RRLHNLANSVIILDEVQAYPPYMLALLLRLLE-WLKNLGGSVILMTATLPPLLREELLEAYelIPDEPEELPEYFRAFV- 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 283 KDRVIVNYDLIyseaPFESLYEHVLKNSKRNKKILIEFIKKQSAYDFFKRLNEDDLNINILLMTGDDNSIERNKIINAIS 362
Cdd:COG1203 340 RKRVELKEGPL----SDEELAELILEALHKGKSVLVIVNTVKDAQELYEALKEKLPDEEVYLLHSRFCPADRSEIEKEIK 415
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 363 SKECEENGVILIATQVIEAGVDIDMDIGYKDISKLDSDEQFMGRINRSCKKS--GEVYFFNLDRVD--KIYKDDFRvnke 438
Cdd:COG1203 416 ERLERGKPCILVSTQVVEAGVDIDFDVVIRDLAPLDSLIQRAGRCNRHGRKEeeGNVYVFDPEDEGggYVYDKPLL---- 491
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1532619538 439 fslldNEMRKILKNKNFY----------EYYDKVLKLLKESNSALND 475
Cdd:COG1203 492 -----ERTRELLREHDEIlpedkrelieEYYRELYELLPDELDSFKE 533
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
69-256 |
5.36e-31 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 119.32 E-value: 5.36e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 69 IYFLEAPTGSGKSNTAFNLSFKLFEgDKNLKKIYYVYPFNALVEQNLNVLNNTFENNEAvSDKIAVINSIYPIKEDKKYI 148
Cdd:cd17930 3 LVILEAPTGSGKTEAALLWALKLAA-RGGKRRIIYALPTRATINQMYERIREILGRLDD-EDKVLLLHSKAALELLESDE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 149 EYDSKENINNgknekdygheyyERALLNRQFLNYPVILTTHVSLFNIMFGDKKEDtFSFHQLANSVIVLDEIQSYKNTIW 228
Cdd:cd17930 81 EPDDDPVEAV------------DWALLLKRSWLAPIVVTTIDQLLESLLKYKHFE-RRLHGLANSVVVLDEVQAYDPEYM 147
|
170 180
....*....|....*....|....*...
gi 1532619538 229 TEIISFLKGFAKILNIKVIIMSATLPDL 256
Cdd:cd17930 148 ALLLKALLELLGELGGPVVLMTATLPAL 175
|
|
| cas3_core |
TIGR01587 |
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ... |
72-438 |
7.86e-26 |
|
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Pssm-ID: 273707 [Multi-domain] Cd Length: 359 Bit Score: 109.08 E-value: 7.86e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 72 LEAPTGSGKSNTAFNLSFKLFEGDKNLKkIYYVYPFNALVEQNLNVLNNTFENNEAVSDKIAVINSIYpIKEDKKYIEYD 151
Cdd:TIGR01587 4 IEAPTGYGKTEAALLWALHSIKSQKADR-VIIALPTRATINAMYRRAKELFGSELVGLHHSSSFSRIK-EMGDSEEFEHL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 152 SKENINNgknekdygheyyerallNRQFLNYPVILTTHVSLFNIMFGDKKEDTFSFHQLANSVIVLDEIQSYKNTIWTEI 231
Cdd:TIGR01587 82 FPLYIHS-----------------NDKLFLDPITVCTIDQVLKSVFGEFGHYEFTLASIANSLLIFDEVHFYDEYTLALI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 232 ISFLKgFAKILNIKVIIMSATLPDLnmLAVNKSNVCNLIKNREKYFSNLKFKDRVIVNYDLIYSEAPFESLyEHVLKNSK 311
Cdd:TIGR01587 145 LAVLE-VLKDNDVPILLMSATLPKF--LKEYAEKIGYVEFNEPLDLKEERRFENHRFILIESDKVGEISSL-ERLLEFIK 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 312 RNKKILIEFIKKQSAYDFFKRLNEDDLNINILL----MTGDDNSIERNKIINAISSKEceENGVIlIATQVIEAGVDIDM 387
Cdd:TIGR01587 221 KGGSIAIIVNTVDRAQEFYQQLKEKAPEEEIILyhsrFTEKDRAKKEAELLREMKKSN--EKFVI-VATQVIEASLDISA 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1532619538 388 DIGYKDISKLDSDEQFMGRINRSCKKSG---EVYFFNLDRVDKIYKDDFRVNKE 438
Cdd:TIGR01587 298 DVMITELAPIDSLIQRLGRLHRYGRKIGenfEVYIITIAPEGKLFPYPYELVER 351
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
66-255 |
9.67e-08 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 52.88 E-value: 9.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 66 NENIYFLEAPTGSGKSnTAFNLSFKLFEGDKNLKKIYYVYPFNALVEQNLNVLNNTFENNeavSDKIAVINSIYPIKEDK 145
Cdd:smart00487 23 GLRDVILAAPTGSGKT-LAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSL---GLKVVGLYGGDSKREQL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 146 KYIEYDskeninngknekdygheyyerallnrqflNYPVILTTHVSLFNIMfgdkKEDTFSFHQLanSVIVLDEIQSYKN 225
Cdd:smart00487 99 RKLESG-----------------------------KTDILVTTPGRLLDLL----ENDKLSLSNV--DLVILDEAHRLLD 143
|
170 180 190
....*....|....*....|....*....|
gi 1532619538 226 TIWTEIISFLkGFAKILNIKVIIMSATLPD 255
Cdd:smart00487 144 GGFGDQLEKL-LKLLPKNVQLLLLSATPPE 172
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
299-409 |
1.03e-04 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 41.81 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 299 FESLYEHVlkNSKRNKKILIeF--IKKQSAYDFFKRLNeddlNINILLMTGDDNSIERNKIINAISSKECEengvILIAT 376
Cdd:pfam00271 3 LEALLELL--KKERGGKVLI-FsqTKKTLEAELLLEKE----GIKVARLHGDLSQEEREEILEDFRKGKID----VLVAT 71
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1532619538 377 QVIEAGVD-------IDMDIGYkdisKLDSDEQFMGRINR 409
Cdd:pfam00271 72 DVAERGLDlpdvdlvINYDLPW----NPASYIQRIGRAGR 107
|
|
| PRK09694 |
PRK09694 |
CRISPR-associated helicase/endonuclease Cas3; |
210-414 |
2.62e-04 |
|
CRISPR-associated helicase/endonuclease Cas3;
Pssm-ID: 182031 [Multi-domain] Cd Length: 878 Bit Score: 44.03 E-value: 2.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 210 LANSVIVLDEIQSYKNTIWTEIISFLKGFAKILNiKVIIMSATLPdlNML------------AVNKSNVCNLIKNR---- 273
Cdd:PRK09694 438 LGRSVLIVDEVHAYDAYMYGLLEAVLKAQAQAGG-SVILLSATLP--ATLkqklldtygghdPVELSSAYPLITWRgvng 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 274 EKYFSNLKFKD----RVIVNYDLIYSEA--PFESLYEHVLKNSkrNKKILIEFI-----KKQSAYDFFKRLNEDDLNINI 342
Cdd:PRK09694 515 AQRFDLSAHPEqlpaRFTIQLEPICLADmlPDLTLLQRMIAAA--NAGAQVCLIcnlvdDAQKLYQRLKELNNTQVDIDL 592
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1532619538 343 L--LMTGDDNSIERNKIINAISSKECEENGVILIATQVIEAGVDIDMDIGYKDISKLDSDEQFMGRINRSCKKS 414
Cdd:PRK09694 593 FhaRFTLNDRREKEQRVIENFGKNGKRNQGRILVATQVVEQSLDLDFDWLITQLCPVDLLFQRLGRLHRHHRKY 666
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
45-475 |
1.51e-77 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 255.78 E-value: 1.51e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 45 DINVLRTEMFlDAERELFENiNENIYFLEAPTGSGKSNTAFNLSFKLFEgDKNLKKIYYVYPFNALVEQNLNVLNNTFEn 124
Cdd:COG1203 127 PINPLQNEAL-ELALEAAEE-EPGLFILTAPTGGGKTEAALLFALRLAA-KHGGRRIIYALPFTSIINQTYDRLRDLFG- 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 125 neavsDKIAVINSiypikedkkyieyDSKENINNGKNEKDYGHEYYeraLLNRQFLNYPVILTTHVSLFNIMFGDKKEDT 204
Cdd:COG1203 203 -----EDVLLHHS-------------LADLDLLEEEEEYESEARWL---KLLKELWDAPVVVTTIDQLFESLFSNRKGQE 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 205 FSFHQLANSVIVLDEIQSYKNTIWTEIISFLKgFAKILNIKVIIMSATLPDLNMLAVNKSN--VCNLIKNREKYFSNLKf 282
Cdd:COG1203 262 RRLHNLANSVIILDEVQAYPPYMLALLLRLLE-WLKNLGGSVILMTATLPPLLREELLEAYelIPDEPEELPEYFRAFV- 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 283 KDRVIVNYDLIyseaPFESLYEHVLKNSKRNKKILIEFIKKQSAYDFFKRLNEDDLNINILLMTGDDNSIERNKIINAIS 362
Cdd:COG1203 340 RKRVELKEGPL----SDEELAELILEALHKGKSVLVIVNTVKDAQELYEALKEKLPDEEVYLLHSRFCPADRSEIEKEIK 415
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 363 SKECEENGVILIATQVIEAGVDIDMDIGYKDISKLDSDEQFMGRINRSCKKS--GEVYFFNLDRVD--KIYKDDFRvnke 438
Cdd:COG1203 416 ERLERGKPCILVSTQVVEAGVDIDFDVVIRDLAPLDSLIQRAGRCNRHGRKEeeGNVYVFDPEDEGggYVYDKPLL---- 491
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1532619538 439 fslldNEMRKILKNKNFY----------EYYDKVLKLLKESNSALND 475
Cdd:COG1203 492 -----ERTRELLREHDEIlpedkrelieEYYRELYELLPDELDSFKE 533
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
69-256 |
5.36e-31 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 119.32 E-value: 5.36e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 69 IYFLEAPTGSGKSNTAFNLSFKLFEgDKNLKKIYYVYPFNALVEQNLNVLNNTFENNEAvSDKIAVINSIYPIKEDKKYI 148
Cdd:cd17930 3 LVILEAPTGSGKTEAALLWALKLAA-RGGKRRIIYALPTRATINQMYERIREILGRLDD-EDKVLLLHSKAALELLESDE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 149 EYDSKENINNgknekdygheyyERALLNRQFLNYPVILTTHVSLFNIMFGDKKEDtFSFHQLANSVIVLDEIQSYKNTIW 228
Cdd:cd17930 81 EPDDDPVEAV------------DWALLLKRSWLAPIVVTTIDQLLESLLKYKHFE-RRLHGLANSVVVLDEVQAYDPEYM 147
|
170 180
....*....|....*....|....*...
gi 1532619538 229 TEIISFLKGFAKILNIKVIIMSATLPDL 256
Cdd:cd17930 148 ALLLKALLELLGELGGPVVLMTATLPAL 175
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
72-430 |
9.87e-27 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 111.75 E-value: 9.87e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 72 LEAPTGSGKSNTAFNLSFKLFEGDKNLKkIYYVYPFNALVEQNLNVLNNTFENNeavsdkiaviNSIYPIKEDKKYIEYD 151
Cdd:cd09639 4 IEAPTGYGKTEAALLWALHSLKSQKADR-VIIALPTRATINAMYRRAKEAFGET----------GLYHSSILSSRIKEMG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 152 SKEninngknekDYGHEYYERALLNRQFLNYPVILTTHVSLFNIMFGDKKEDTFSFHQLANSVIVLDEIQSYKNTIWTEI 231
Cdd:cd09639 73 DSE---------EFEHLFPLYIHSNDTLFLDPITVCTIDQVLKSVFGEFGHYEFTLASIANSLLIFDEVHFYDEYTLALI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 232 ISFLKgFAKILNIKVIIMSATLPDLnmLAVNKSNVCNLIKNRekyFSNLKFKDRVIVNYDLIYSEAPFESLyEHVLKNSK 311
Cdd:cd09639 144 LAVLE-VLKDNDVPILLMSATLPKF--LKEYAEKIGYVEENE---PLDLKPNERAPFIKIESDKVGEISSL-ERLLEFIK 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 312 RNKKILIEFIKKQSAYDFFKRLNEDDLNINILL----MTGDDNSIERNKIINAISSKEceeNGVIlIATQVIEAGVDIDM 387
Cdd:cd09639 217 KGGSVAIIVNTVDRAQEFYQQLKEKGPEEEIMLihsrFTEKDRAKKEAELLLEFKKSE---KFVI-VATQVIEASLDISV 292
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1532619538 388 DIGYKDISKLDSDEQFMGRINRSCKKSG-EVYFFNLDRVDKIYK 430
Cdd:cd09639 293 DVMITELAPIDSLIQRLGRLHRYGEKNGeEVYIITDAPDGKGQK 336
|
|
| cas3_core |
TIGR01587 |
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ... |
72-438 |
7.86e-26 |
|
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Pssm-ID: 273707 [Multi-domain] Cd Length: 359 Bit Score: 109.08 E-value: 7.86e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 72 LEAPTGSGKSNTAFNLSFKLFEGDKNLKkIYYVYPFNALVEQNLNVLNNTFENNEAVSDKIAVINSIYpIKEDKKYIEYD 151
Cdd:TIGR01587 4 IEAPTGYGKTEAALLWALHSIKSQKADR-VIIALPTRATINAMYRRAKELFGSELVGLHHSSSFSRIK-EMGDSEEFEHL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 152 SKENINNgknekdygheyyerallNRQFLNYPVILTTHVSLFNIMFGDKKEDTFSFHQLANSVIVLDEIQSYKNTIWTEI 231
Cdd:TIGR01587 82 FPLYIHS-----------------NDKLFLDPITVCTIDQVLKSVFGEFGHYEFTLASIANSLLIFDEVHFYDEYTLALI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 232 ISFLKgFAKILNIKVIIMSATLPDLnmLAVNKSNVCNLIKNREKYFSNLKFKDRVIVNYDLIYSEAPFESLyEHVLKNSK 311
Cdd:TIGR01587 145 LAVLE-VLKDNDVPILLMSATLPKF--LKEYAEKIGYVEFNEPLDLKEERRFENHRFILIESDKVGEISSL-ERLLEFIK 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 312 RNKKILIEFIKKQSAYDFFKRLNEDDLNINILL----MTGDDNSIERNKIINAISSKEceENGVIlIATQVIEAGVDIDM 387
Cdd:TIGR01587 221 KGGSIAIIVNTVDRAQEFYQQLKEKAPEEEIILyhsrFTEKDRAKKEAELLREMKKSN--EKFVI-VATQVIEASLDISA 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1532619538 388 DIGYKDISKLDSDEQFMGRINRSCKKSG---EVYFFNLDRVDKIYKDDFRVNKE 438
Cdd:TIGR01587 298 DVMITELAPIDSLIQRLGRLHRYGRKIGenfEVYIITIAPEGKLFPYPYELVER 351
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
66-255 |
9.67e-08 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 52.88 E-value: 9.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 66 NENIYFLEAPTGSGKSnTAFNLSFKLFEGDKNLKKIYYVYPFNALVEQNLNVLNNTFENNeavSDKIAVINSIYPIKEDK 145
Cdd:smart00487 23 GLRDVILAAPTGSGKT-LAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSL---GLKVVGLYGGDSKREQL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 146 KYIEYDskeninngknekdygheyyerallnrqflNYPVILTTHVSLFNIMfgdkKEDTFSFHQLanSVIVLDEIQSYKN 225
Cdd:smart00487 99 RKLESG-----------------------------KTDILVTTPGRLLDLL----ENDKLSLSNV--DLVILDEAHRLLD 143
|
170 180 190
....*....|....*....|....*....|
gi 1532619538 226 TIWTEIISFLkGFAKILNIKVIIMSATLPD 255
Cdd:smart00487 144 GGFGDQLEKL-LKLLPKNVQLLLLSATPPE 172
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
72-533 |
9.72e-08 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 55.03 E-value: 9.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 72 LEAPTGSGKSNTAFNLSFKLFEGdknlKKIYYVYPFNALVEQNLnvlnntfenneavsdkiavinsiypikedKKYIEYD 151
Cdd:COG1061 105 VVAPTGTGKTVLALALAAELLRG----KRVLVLVPRRELLEQWA-----------------------------EELRRFL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 152 SKENINNGKNEKDYgheyyerallnrqflnyPVILTTHVSLFNIMFGDKKEDTFSFhqlansvIVLDEIQSYKNTIWTEI 231
Cdd:COG1061 152 GDPLAGGGKKDSDA-----------------PITVATYQSLARRAHLDELGDRFGL-------VIIDEAHHAGAPSYRRI 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 232 ISFLKgFAKILNikviiMSATLPDLNMLAVNKSNVCNLIKN-------REKYFSNLKFKdRVIVNYDLIYSE--APFESL 302
Cdd:COG1061 208 LEAFP-AAYRLG-----LTATPFRSDGREILLFLFDGIVYEyslkeaiEDGYLAPPEYY-GIRVDLTDERAEydALSERL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 303 YEHVLKNSKRNKKILIEFIKK--------------QSAYDFFKRLNEDDlnINILLMTGDDNSIERNKIINAISSKECEe 368
Cdd:COG1061 281 REALAADAERKDKILRELLREhpddrktlvfcssvDHAEALAELLNEAG--IRAAVVTGDTPKKEREEILEAFRDGELR- 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 369 ngvILIATQVIEAGVDI-DMDIGYkDISKLDSD---EQFMGRINRSCKKSGEVYFFNL-----DRVDKIYKD-DFRVNKE 438
Cdd:COG1061 358 ---ILVTVDVLNEGVDVpRLDVAI-LLRPTGSPrefIQRLGRGLRPAPGKEDALVYDFvgndvPVLEELAKDlRDLAGYR 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 439 FSLLDNEMRKILKNKNFYEYYDKVLKLLKESNSALNDGNIEKFFKENVWMLNFNKISERMKLIEDDNWSMSVYLARNIHE 518
Cdd:COG1061 434 VEFLDEEESEELALLIAVKPALEVKGELEEELLEELELLEDALLLVLAELLLLELLALALELLELAKAEGKAEEEEEEKE 513
|
490
....*....|....*
gi 1532619538 519 GEVNLDGEKIWNDYK 533
Cdd:COG1061 514 LLLLLALAKLLKLLL 528
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
54-273 |
9.92e-08 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 52.26 E-value: 9.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 54 FLDAERELFENI---NENIyFLEAPTGSGKSNTAFNLSFKLFEgdKNLKKIYYVYPFNALVEQNLNVLNNTFENNEavsD 130
Cdd:cd17921 2 LNPIQREALRALylsGDSV-LVSAPTSSGKTLIAELAILRALA--TSGGKAVYIAPTRALVNQKEADLRERFGPLG---K 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 131 KIAVINSiypikedkkyieyDSKENInngknekdygheyyerallnRQFLNYPVILTTHVSlFNIMFGDKKEDTFSFHQL 210
Cdd:cd17921 76 NVGLLTG-------------DPSVNK--------------------LLLAEADILVATPEK-LDLLLRNGGERLIQDVRL 121
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1532619538 211 ansvIVLDEIQSYKN----TIWTEIISFLKGFAKilNIKVIIMSATLPDLNMLAvNKSNVCNLIKNR 273
Cdd:cd17921 122 ----VVVDEAHLIGDgergVVLELLLSRLLRINK--NARFVGLSATLPNAEDLA-EWLGVEDLIRFD 181
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
71-252 |
4.15e-06 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 46.63 E-value: 4.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 71 FLEAPTGSGKSNTAFNLSFKLFegDKNLKKIYYVYPFNALVEQNLNVLNNTFENNeavsDKIAVINSIYPIKEDKKYIEY 150
Cdd:cd00046 5 LITAPTGSGKTLAALLAALLLL--LKKGKKVLVLVPTKALALQTAERLRELFGPG----IRVAVLVGGSSAEEREKNKLG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 151 DskeninngknekdygheyyerallnrqflnYPVILTTHVSLFNIMfgdKKEDTFSFHQLanSVIVLDE---IQSYKNTI 227
Cdd:cd00046 79 D------------------------------ADIIIATPDMLLNLL---LREDRLFLKDL--KLIIVDEahaLLIDSRGA 123
|
170 180
....*....|....*....|....*
gi 1532619538 228 WTEIISFLKGFAKilNIKVIIMSAT 252
Cdd:cd00046 124 LILDLAVRKAGLK--NAQVILLSAT 146
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
331-409 |
1.21e-05 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 43.74 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 331 KRLNEddLNINILLMTGDDNSIERNKIINAISSKECeengVILIATQVIEAGVD-------IDMDIgykDISKlDSDEQF 403
Cdd:smart00490 5 ELLKE--LGIKVARLHGGLSQEEREEILDKFNNGKI----KVLVATDVAERGLDlpgvdlvIIYDL---PWSP-ASYIQR 74
|
....*.
gi 1532619538 404 MGRINR 409
Cdd:smart00490 75 IGRAGR 80
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
74-159 |
3.61e-05 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 45.01 E-value: 3.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 74 APTGSGKsnTAFNLSFKLFEGDKNlKKIYYVYPFNALVEQNLNVLnNTFENNEAVSDKIAVINSIYPIKEDKKyieydSK 153
Cdd:cd17924 39 APTGVGK--TTFGLATSLYLASKG-KRSYLIFPTKSLVKQAYERL-SKYAEKAGVEVKILVYHSRLKKKEKEE-----LL 109
|
....*.
gi 1532619538 154 ENINNG 159
Cdd:cd17924 110 EKIEKG 115
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
299-386 |
1.03e-04 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 42.49 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 299 FESLYEHvLKNSKRNKKILIeFIK-KQSAYDFFKRLNEddLNINILLMTGDDNSIERNKIINAISSKECEengvILIATQ 377
Cdd:cd18787 14 KLLLLLL-LLEKLKPGKAII-FVNtKKRVDRLAELLEE--LGIKVAALHGDLSQEERERALKKFRSGKVR----VLVATD 85
|
....*....
gi 1532619538 378 VIEAGVDID 386
Cdd:cd18787 86 VAARGLDIP 94
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
299-409 |
1.03e-04 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 41.81 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 299 FESLYEHVlkNSKRNKKILIeF--IKKQSAYDFFKRLNeddlNINILLMTGDDNSIERNKIINAISSKECEengvILIAT 376
Cdd:pfam00271 3 LEALLELL--KKERGGKVLI-FsqTKKTLEAELLLEKE----GIKVARLHGDLSQEEREEILEDFRKGKID----VLVAT 71
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1532619538 377 QVIEAGVD-------IDMDIGYkdisKLDSDEQFMGRINR 409
Cdd:pfam00271 72 DVAERGLDlpdvdlvINYDLPW----NPASYIQRIGRAGR 107
|
|
| PRK09694 |
PRK09694 |
CRISPR-associated helicase/endonuclease Cas3; |
210-414 |
2.62e-04 |
|
CRISPR-associated helicase/endonuclease Cas3;
Pssm-ID: 182031 [Multi-domain] Cd Length: 878 Bit Score: 44.03 E-value: 2.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 210 LANSVIVLDEIQSYKNTIWTEIISFLKGFAKILNiKVIIMSATLPdlNML------------AVNKSNVCNLIKNR---- 273
Cdd:PRK09694 438 LGRSVLIVDEVHAYDAYMYGLLEAVLKAQAQAGG-SVILLSATLP--ATLkqklldtygghdPVELSSAYPLITWRgvng 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 274 EKYFSNLKFKD----RVIVNYDLIYSEA--PFESLYEHVLKNSkrNKKILIEFI-----KKQSAYDFFKRLNEDDLNINI 342
Cdd:PRK09694 515 AQRFDLSAHPEqlpaRFTIQLEPICLADmlPDLTLLQRMIAAA--NAGAQVCLIcnlvdDAQKLYQRLKELNNTQVDIDL 592
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1532619538 343 L--LMTGDDNSIERNKIINAISSKECEENGVILIATQVIEAGVDIDMDIGYKDISKLDSDEQFMGRINRSCKKS 414
Cdd:PRK09694 593 FhaRFTLNDRREKEQRVIENFGKNGKRNQGRILVATQVVEQSLDLDFDWLITQLCPVDLLFQRLGRLHRHHRKY 666
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
317-420 |
1.34e-03 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 39.63 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 317 LIEFIKK---QSAYDFFKRLNED-DLNINILLMTGDDNSIERNKIINAISSKECEengvILIATQVIEAGVDID----MD 388
Cdd:cd18811 35 LIEESEKldlKAAVAMYEYLKERfRPELNVGLLHGRLKSDEKDAVMAEFREGEVD----ILVSTTVIEVGVDVPnatvMV 110
|
90 100 110
....*....|....*....|....*....|..
gi 1532619538 389 IGYKDISKLDSDEQFMGRINRSCKKSgevYFF 420
Cdd:cd18811 111 IEDAERFGLSQLHQLRGRVGRGDHQS---YCL 139
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
72-148 |
1.85e-03 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 39.21 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 72 LEAPTGSGKSNTAFNLSFKLFEgdknlKKIYYVYPFNALVEQNLNVLNNTF----------ENNEAVSDK---IAVINSI 138
Cdd:cd17926 23 LVLPTGSGKTLTALALIAYLKE-----LRTLIVVPTDALLDQWKERFEDFLgdssigliggGKKKDFDDAnvvVATYQSL 97
|
90
....*....|
gi 1532619538 139 YPIKEDKKYI 148
Cdd:cd17926 98 SNLAEEEKDL 107
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
55-148 |
6.37e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 37.65 E-value: 6.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1532619538 55 LDAERELFENINENIYFlEAPTGSGKSNTAFNLSFKLFEgDKNLKKIYYVYPFNALVEQNLNVLNNTFENNEAVSDKIAV 134
Cdd:pfam04851 12 IENLLESIKNGQKRGLI-VMATGSGKTLTAAKLIARLFK-KGPIKKVLFLVPRKDLLEQALEEFKKFLPNYVEIGEIISG 89
|
90
....*....|....
gi 1532619538 135 INSIyPIKEDKKYI 148
Cdd:pfam04851 90 DKKD-ESVDDNKIV 102
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
64-116 |
9.91e-03 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 37.74 E-value: 9.91e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1532619538 64 NINENIyFLEAPTGSGKSNTAFNLSFKLFEgDKNLKKIYYVYPFNALVEQNLN 116
Cdd:cd18022 15 HTDNNV-LLGAPTGSGKTIAAELAMFRAFN-KYPGSKVVYIAPLKALVRERVD 65
|
|
| |
