|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-398 |
6.60e-89 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 273.28 E-value: 6.60e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 31 ALAHLINDLIQAVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFV 110
Cdd:cd17478 2 SLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 111 GSFPAILMAAALVGIGSSTFHPEASRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAWFGLFAAFA 190
Cdd:cd17478 82 PNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 191 IVVLYGLSRWYRHHLtlfKLKQGGMATHGLSSGRVKFALLILALLVFSKYFYMASFTSYFTFFLIEKFdLSVASSQLYLF 270
Cdd:cd17478 162 VALLLLRLRPLKKPE---AKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 271 LFLGAVAAGTFFGGPIGDRIGRKQVIWFSILGVAPFSLLLPHVDLFWTGVLSMVIGFILASAFSAIVVFAQELMPGNVGM 350
Cdd:cd17478 238 LFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGL 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1539005408 351 IAGLFFGLMFGFGGIGGALLGYLADIHGIEEVFLLCSFLPLLGILTAL 398
Cdd:cd17478 318 ASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-348 |
1.64e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 108.91 E-value: 1.64e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 17 SQASPLVMRVIGACALAHLINDLIQAVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAG 96
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 97 SLCTLVGILMLAFVGSFPAILMAAALVGIGSSTFHPEA-SRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPY 175
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAAlALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 176 GQGNVawFGLFAAFAIVVLYGLSRWYRHHLTLFKLKQGGMATHGLSSGRVKFALLILALLVFSkyfyMASFTSYFTFFLI 255
Cdd:COG2814 162 GWRWV--FLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFG----FFALFTYLPLYLQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 256 EKFDLSVASSQLYLFLFLGAVAAGTFFGGPIGDRIGRKQVIWFSILGVAPFSLLLPHVDLFWTGVLSMVI-GFILASAFS 334
Cdd:COG2814 236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLlGFGFGLLFP 315
|
330
....*....|....
gi 1539005408 335 AIVVFAQELMPGNV 348
Cdd:COG2814 316 LLQALVAELAPPEA 329
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
25-405 |
2.47e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 105.72 E-value: 2.47e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 25 RVIGACALAHLINDLIQAVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGI 104
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 105 LMLAFVGSFPAILMAAALVGIGSSTFHPEASR-IARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGqgnvaWF 183
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKlIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-----WR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 184 GLFAAFAIVVLYGLSrwyrhhltlfklkqggmathglssgrvkFALLILALLVFSKYFYMASFTSYFTFFLIEKFDLSVA 263
Cdd:COG2271 165 AAFLILGLPGLLLAL----------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 264 SSQLYLFLFLGAVAAGTFFGGPIGDRIGR--KQVIWFSILGVAPFSLLLPHVDLFWTGVLSMVI-GFILASAFSAIVVFA 340
Cdd:COG2271 217 QAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLaGFGLGGAFGLLWALA 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1539005408 341 QELMPGN-VGMIAGLFFGLMFGFGGIGGALLGYLADIHGIEEVFLLCSFLPLLGILTALLPSLKTR 405
Cdd:COG2271 297 AELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
24-340 |
3.45e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 88.40 E-value: 3.45e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 24 MRVIGACALAHLINDLIQAVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVG 103
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 104 ILMLAFVGSFPAILMAAALVGIGSSTFHPEASR-IARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAW 182
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIAlVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 183 FGLFAAFAIVVLYglsrwyrhHLTLFKLKQGGMATHGLSSGRVKFAL-----LILALLVFSKYFYMASFTSYFTFFLIEK 257
Cdd:COG2223 164 ILGILLLVVAVLA--------WLFLRDPPAGAAAAAKASLRDQLEALrdprfWLLSLLYFGTFGSFIGFSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 258 FDLSVASSQLYLFLFLGAVAAGTFFGGPIGDRIGRKQVIWFSILGVAPFSLLLPHVDLFWTGVLSMVIGFILASAFSAIV 337
Cdd:COG2223 236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGA 315
|
...
gi 1539005408 338 VFA 340
Cdd:COG2223 316 VFA 318
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-345 |
1.22e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.93 E-value: 1.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 31 ALAHLINDLIQAVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFV 110
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 111 GSFPAILMAAALVGIGSSTFHPEASR-IARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAWFGLFAAF 189
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLAlIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 190 AIVVLYGLSRWYRHHLTLFKLKQGGMATHGLSSGRVKF----ALLILALLVFSKYFYMASFTSYFTFFLIEKFDLSVASS 265
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVlknpGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 266 QLYLFLFLGAVAAGTFFGGPIGDR-IGRKQVIWFSILGVAPFSLLLPHVDLFWTGVLSM-VIGFILASAFSAIVVFAQEL 343
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLlLLGFGLGGLLPLSFALIAEL 321
|
..
gi 1539005408 344 MP 345
Cdd:cd06174 322 FP 323
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
42-347 |
3.07e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.38 E-value: 3.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 42 AVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAA 121
Cdd:pfam07690 14 LLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 122 LVGIGSSTFHPEASR-IARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAWFGLFAAFAIVVLYGLSRW 200
Cdd:pfam07690 94 LQGLGAGALFPAALAlIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 201 YRHHLTLFKLKQGGMATHGLSSGRVKFALLILALLVFSKYFYMASFTSYFTFFlIEKFDLSVASSQLYLFLFLGAVAAGT 280
Cdd:pfam07690 174 PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGR 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1539005408 281 FFGGPIGDRIGRKQVIWFSILGVAPFSLLLPHV----DLFWTGVLSMVIGFILASAFSAIVVFAQELMPGN 347
Cdd:pfam07690 253 LLLGRLSDRLGRRRRLLLALLLLILAALGLLLLsltlSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKE 323
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
25-399 |
6.08e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 78.74 E-value: 6.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 25 RVIGACALAHLINDLIQAVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGI 104
Cdd:COG0738 8 RALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 105 LMLAFVGSFPAILMAAALVGIGSSTF----HPEASRIARLASGGRYGLAQSTFqvggNAGTAFGPLLAAAIIipYGQGNV 180
Cdd:COG0738 88 LLFALAPSYPLLLLALFLLGLGLGLLdvaaNPYVAALGPETAASRLNLLHAFF----SLGALLGPLLGGLLI--LLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 181 AWFGLFAAFAIVVLYGLSRWYRHHLTLFKLKQGGMATHGLSSGRV--KFALLILALLVFSKYFYMASFTSYFTFFLIEKF 258
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLlkNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 259 DLSVASSQLYLFLFLGAVAAGTFFGGPIGDRIGRKQVIWFSILGVAPFSLLLPHVDLFWTGVLSMV-IGFILASAFSAIV 337
Cdd:COG0738 242 GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLAlVGLGLSLMFPTIF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539005408 338 VFAQELMPGNVGMIAGLFFGLMFGFGGIGGALLGYLADIHGIEEVFLLCSFLPLLGILTALL 399
Cdd:COG0738 322 SLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
56-345 |
5.39e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.61 E-value: 5.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 56 GLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAALVGIGSSTFHPEA- 134
Cdd:cd17325 27 GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAm 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 135 SRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAWFGLFAAFAIVVLYGLSRWYRHHLTLFKLKQGG 214
Cdd:cd17325 107 ALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 215 MATHGLSSGRVKFALLILALLVFSKYFYMASFTSYFTFFLIEKFDLSVASSQLYLFLFLGAVAAGTFFGGPIGDRIGRKQ 294
Cdd:cd17325 187 RLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP 266
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1539005408 295 VIWFSILGVAPFSLLLPHVDLFWT-GVLSMVIGFILASAFSAIVVFAQELMP 345
Cdd:cd17325 267 LILIGLLLSAVALLLLPLATSFWLlLLLLALLGLGLGLVFPATLALLADIVP 318
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
32-327 |
2.08e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 64.95 E-value: 2.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 32 LAHLINDLIQAVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVG 111
Cdd:cd17475 3 LAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 112 SFPAILMAAALVGIGSSTFHPEASR-IARLASGGRYGLAQSTFQVGGNAGTAFgpllaAAIIIPYGQGNVAWFGLFAAFA 190
Cdd:cd17475 83 SYPVLLVLLFLVGAGYGSVQPGGGRaIMRWFPPRERGLAMGIRQTGVPLGGAL-----AAALLPPLALHYGWRAAFVVAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 191 IVVLYG---LSRWYRHHLTlfKLKQGGMATHGLSSGRVKFALLILALLVFSKYFYMA---SFTSYFTFFLIEKFDLSVAS 264
Cdd:cd17475 158 LVSILAavlFWLFYREPPA--ASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVApqfALLTFLLLFLHDHLGLSVVA 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 265 SQLYLFLFLGAVAAGTFFGGPIGDRIG---RKQVI----WFSILGVAPFSLLLPHVDLFWTGVLSMVIGF 327
Cdd:cd17475 236 AGALLAVAQLGGALGRIGLGRVSDRVFggrRRPVLvitaAIAAAALLVLSLLSPGTPLWLLVLLLILLGL 305
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
26-337 |
2.09e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 64.90 E-value: 2.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 26 VIGACALAHLINDLIQAVLPAIYPMLklnyGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGIL 105
Cdd:cd17474 4 VFFATLLAVLGVSIVDPILPAIAEAL----GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 106 MLAFVGSFPAILMAAALVGIGSSTFHPEA-SRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIiipygqGNVAWFG 184
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLAlTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL------AAISWRY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 185 LFAAFAIVVLYGLSRWY-----RHHLTLFKLKQGGMATHGLSSGRVKFALLILALLVFSKYFymaSFTSYFTFFLIEKFD 259
Cdd:cd17474 154 PFFLLAALIPVAFLAILfllpePKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYF---AFLTYLPFLLELLYG 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1539005408 260 LSVASSQLYLFLFLGAVAAGTFFGGPI-GDRIGRKQVIWFSILGVAPFSLLLPhvdlFWTGVLSMVIGFILASAFSAIV 337
Cdd:cd17474 231 ISPIIIGLLFAGWSVLLALGSLFVGRLlKKRFGARRILVIGLLLYALSLLLLG----FVPSLALLLIAIVLFGLGLGLN 305
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
35-334 |
2.63e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.84 E-value: 2.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 35 LINDLIQAVLPAIYPMlklNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHP------KPWLLPAGSLCTLVGILM-- 106
Cdd:COG2211 24 LAFGLLSAYLLYFYTD---VLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrrRPWILIGAIPLALSFVLLft 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 107 ---LAFVGSFPAILMAAALVGIGSSTFH-PEASRIARLASGGRY-GLAQSTFQVGGNAGTAFGPLLAAAIIIPYG---QG 178
Cdd:COG2211 101 apdLSPTGKLIYALVTYLLLGLAYTLVNiPYSALGAELTPDYEErTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaAL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 179 NVAWFGLFAAFAIVVLYGLSRWYRHHLTLFKLKQGGMATHGLSSGRVKfALLILALLVFSKYFYMASFTSYFTFFLIEKF 258
Cdd:COG2211 181 GYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNR-PFLLLLLAYLLFFLALALVAALLLYYFKYVL 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1539005408 259 DLSVASSQLYLFLFLGAVAAGTFFGGPIGDRIGRKQVIWFSILGVAPFSL---LLPHVDLFWTGVLSMVIGFILASAFS 334
Cdd:COG2211 260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLllfFLGPGNLWLLLVLAALAGIGLGAILV 338
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
42-345 |
1.07e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 59.89 E-value: 1.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 42 AVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAA 121
Cdd:COG2807 35 TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 122 LVGIGSSTFHPEASRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYG-QGNVAWFGLFAAFAIVVLYGLSRw 200
Cdd:COG2807 115 LIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGwRGALAVWALLALLALLLWLPLLR- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 201 yRHHLTLFKLKQGGMATHGLSSGRvkFALLILALLVFSKYFYMasFTSYFTFFLIEKfDLSVASSQLYLFLFLGAVAAGT 280
Cdd:COG2807 194 -RRPAAAAAAPAAASLRSLWRSPL--AWLLTLFFGLQSLLYYA--VVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGS 267
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1539005408 281 FFGGPIGDRIGRKQVIWFSILGVAPFSLL-LPHVDLFWTGVLSMVIGFILASAFSAIVVFAQELMP 345
Cdd:COG2807 268 LLVPLLADRLGDRRPLLLLLGLLGLAGLLgLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRAR 333
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-199 |
1.12e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.51 E-value: 1.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 2 SSSPAATPLAGASPVSQASPLVMRVIGACALAHLINDLIQAVLPAIYPM-LKLNYGLSFAQIGLITLTFQLTASLLQPWV 80
Cdd:cd17325 176 PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 81 GYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAALVGIGSSTFHP-EASRIARLASGGRYGLAQSTFQVGGNA 159
Cdd:cd17325 256 GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPaTLALLADIVPPEGRGTAMGLFNTAFSL 335
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1539005408 160 GTAFGPLLAAAIIIPYGQGNVAWFGLFAAFAIVVLYGLSR 199
Cdd:cd17325 336 GMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
49-338 |
4.05e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 57.94 E-value: 4.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 49 PMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAALVGIGSS 128
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 129 TFHPEA-SRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVawFGLFAAFAIVVLYGLSRWYRH--HL 205
Cdd:cd17324 103 GFWAIAaAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA--FLAIAVLALLAALLLWRLLPSlpPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 206 TLFKLKQGGMATHGLSSGRVKFALLILALLVFSkyfyMASFTSYFTFFLIEKFDLSVASSQLYLFLFLGAVAAGTFFGGP 285
Cdd:cd17324 181 KPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGG----FFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1539005408 286 IGDRIGRKQVIWFSILGVAPFSLLLphvdLFWTGVLSMVIGFILASAFSAIVV 338
Cdd:cd17324 257 LADRGGRRALLIALLLLAAALLLLT----LLGPSPLLLLVGLVLWGLGFFAAH 305
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
53-344 |
8.13e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 53.75 E-value: 8.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 53 LNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAALVGIGSSTFHP 132
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 133 EASRI-ARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAWFGLFAAFAIVVLyGLSRWYRHHltlfKLK 211
Cdd:cd17489 104 AAATLvADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLL-VFLVKDPPP----VAA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 212 QGGMATHGLSSGRVKFALLILALLVFSKYFYMASFTSYFTFFLIEkfdLSVASSQLYLFLFLGAVAAGTFFGGPIGDRIG 291
Cdd:cd17489 179 EEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAE---RGISNAGLFFTVYAIALLLSRPFSGKLSDRKG 255
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1539005408 292 RKQVIWFSILGVAPFSLLLPHVDLFWtgvLSMVIGFILASAFSAIVVFAQELM 344
Cdd:cd17489 256 PKTVIIPGLLLLALGLLLLSFAGSPW---MLLLAAVLYGLGFGLLFPALQALA 305
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
32-340 |
9.22e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 53.78 E-value: 9.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 32 LAHLINDLIQAVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVG 111
Cdd:cd17328 6 LINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 112 SFPAILMAAALVGIGSSTFHPEA-SRIARLASGGRYGLAQSTFQVGGNAGTA----FGPLLAAAIiipygqGNVAWFGLF 186
Cdd:cd17328 86 NFWQLLLFRALVGIGEASYSPIApTIIADLFPKEKRTRALGVFYFAIPLGSGlgyvVGGLVAQAT------GGWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 187 AAFAIVVLYGLSRWYRHHLTLFKLKQGGMATHGLSSGRVKFALL------ILALLVFSKYFYMASFTSYFT-FFLIEKFD 259
Cdd:cd17328 160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALaknpsfILSTLGFTAVSFVTGALAFWApTFFLRAFG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 260 LSVASSQLYLFLFLGAVAAGTFFGGPIGDRIGRKQVIW----------FSILGVAPFSLLLPHVDL--FWTGVLSMVIGF 327
Cdd:cd17328 240 VGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKtpradplvcaVGLLAAAPFLFLALVLALsnLLLAWVLLFLGE 319
|
330
....*....|...
gi 1539005408 328 ILASAFSAIVVFA 340
Cdd:cd17328 320 FLLSLNWAPVFAI 332
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
44-332 |
9.99e-08 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 53.41 E-value: 9.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 44 LPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMA-AAL 122
Cdd:cd17341 18 FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWGLLVlGFL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 123 VGIGSSTFHPEASRIARLASGGRYGLAQSTFQVGGNAGTA----FGPLLAAAIIIPYGQGNVAW-FGLFAAFAIVVLYGL 197
Cdd:cd17341 98 LGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAvsqlLAPLIAGAIVFDGGFVGWRNaFFVPGILLAIAAVLV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 198 SRWYRHHLT--LFKLKQGGMATHGLSSGRVkfalLILALLVFSKYFYMASFTSYFTFFLIEKFDLSVASSQLYLFLFLGA 275
Cdd:cd17341 178 LLFGDDLPTgkASALEFLKVQLAVLKNYRT----WILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLA 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539005408 276 VAAGTFFGGPIGDRIGRKQVIWFS-----ILGVAPFSLLLPHVDLFWTGVLSMVIGFILASA 332
Cdd:cd17341 254 GALARPAGGWLSDRFGGRRRLWWLfivmtIGAALLSLSLPTSGTNLVLFLALFVALGLGAGA 315
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
42-200 |
1.08e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 53.39 E-value: 1.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 42 AVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAA 121
Cdd:cd17329 17 MVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 122 LVGIGSSTFHPEASR-IARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIpYGQGNVAWFG--LFAAFAIVVLYGLS 198
Cdd:cd17329 97 LTGFGGGLFEPASEAmIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAavLFLLAALVLLFLLP 175
|
..
gi 1539005408 199 RW 200
Cdd:cd17329 176 ET 177
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
30-338 |
1.44e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.09 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 30 CALAHLINDLIQAVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAF 109
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 110 VGSFPAILMAAALVGIGSSTFHPEASRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIipygQGNVAWFGLFAAF 189
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLL----TSELSWSWAYLII 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 190 AIVVLYGLSRWYR-----HHLTLFKLKQGGMATHGLSSGRVKFALLILALLVFSKYFYMASFTSYFTFFLIEKFDLSVAS 264
Cdd:cd17333 157 GLIYLLLAILILLtlfpeLPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGL 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1539005408 265 SQLYLFLFLGAVAAGTFFGGPIGDRIGRKQVIWFSILGVAPFSLLLphvdLFWTGVLSMVIGFILASAFSAIVV 338
Cdd:cd17333 237 AGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLIL----LLAPTLVVGLVATALLGLFMAALF 306
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
56-348 |
2.61e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 52.19 E-value: 2.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 56 GLSFAQIGLITLTFQLTASLLQPWVGYHTDRH-PKPWLLPAGSLCTLVGILMlAFVGSFPAILMAAALVGIGSSTFHPEA 134
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFgARKVLAVSMLLWSLFTALT-GFATSLTSLYVLRFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 135 SR-IARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIipygqGNVAWFGLFAAFAIV-VLYGLsrwyrhhLTLFKLKQ 212
Cdd:cd17319 113 IKaLAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL-----LLFGWRWAFIIEGLLgLLLAV-------LWWFYLRQ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 213 ggmathglssgrvkfaLLILALLVFSKYFYMASFTSYFTFFLIEKFDLSVASSQLYLFLFLGAVAAGTFFGGPIGDRI-- 290
Cdd:cd17319 181 ----------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlr 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 291 -GRKQVIWFSILGVAPFSLLLPHVDLFWTGVLSMVIGFILASAFSAIV-VFAQELMPGNV 348
Cdd:cd17319 245 gARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFwSLPADLLPGEA 304
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
60-399 |
2.96e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.23 E-value: 2.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 60 AQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLL---PAGSLCTLVGILMLAFVG--SFPAILMAAALVGIGSSTFHP-E 133
Cdd:cd06173 34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLilaDLLRALLAAVLALLALLGslSLWLLLVLAFLLGIASAFFGPaR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 134 ASRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAWF-GLFAAFAIVVLYGLSRWYRHHLTLFKLKQ 212
Cdd:cd06173 114 QALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAInALSFLLSALLLLFIRRPPPAAPGESSSLL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 213 GGMATHGLSSGRVKFALLILALLVFSKYFYMASFTSYFTFFLIEKFDLSVASSQLYLFLFLGAVAAGTFFGGPIGDRIGR 292
Cdd:cd06173 194 LRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRR 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 293 KQVIWFSILGVAPFSLLLPHVDLFWTGVLSMVI-GFILASAFSAIVVFAQELMPGNV-GMIAGLFFGLMFGFGGIGGALL 370
Cdd:cd06173 274 GRLLLIGALLLGLALLVLGLSPSLWLLLAALFLlGLAGGLFNVPLNTLLQLRVPDELrGRVFSVYNALNSGAMPLGALLA 353
|
330 340
....*....|....*....|....*....
gi 1539005408 371 GYLADIHGIEEVFLLCSFLPLLGILTALL 399
Cdd:cd06173 354 GLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
49-194 |
8.95e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 50.63 E-value: 8.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 49 PMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAALVGIGSS 128
Cdd:cd17324 223 PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1539005408 129 TFHPEA-SRIARLASGGRyGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAWFGLFAAFAIVVL 194
Cdd:cd17324 303 AAHSALqTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
29-349 |
5.19e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 48.07 E-value: 5.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 29 ACALAHLINDLIQAVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLA 108
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 109 FVGSFPAILMAAALVGIGS-STFHPEASRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAaIIIPYGQGNVAWFGLF- 186
Cdd:cd17371 83 FAQNYWQLLILRALAGLGFgGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAA-LLFPLLPPEIAWRVLFl 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 187 -----AAFAIVVLYGL---SRWYRHHLTLFKLKQGGMATHGLSSGRVKFALLILALLVFSKYFYMASfTSYFTFFLIEKF 258
Cdd:cd17371 162 lgalpALLVLFIRRFVkepPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGI-TTWLPSYLTGER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 259 DLSVASSQLYLFLFLGAVAAGTFFGGPIGDRIGRKQVIWFSILGVAPFSLL--LPHVDLFWTGVLSMVIGFILASAFSAI 336
Cdd:cd17371 241 GLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLyfFLPLSPTLILILGFPLGFFASGPFSGM 320
|
330
....*....|...
gi 1539005408 337 VVFAQELMPGNVG 349
Cdd:cd17371 321 GAYLTELFPTAVR 333
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
114-348 |
2.29e-05 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 46.13 E-value: 2.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 114 PAILMAAAL-----VGIGSSTFHPEASRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAW---FGL 185
Cdd:cd17367 101 PIILLLARLlqglsVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLGEDQMAAWGWripFLL 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 186 FAAFAIVVLYgLSRWYRHHLTLFKLKQGGMATHGLSSGRVKF---ALLILAL-LVFSKYFYmaSFTSYFTFFLIEKFDLS 261
Cdd:cd17367 181 GGVLAVVVLW-LRRGLEETESFEAIAESNEASAGTLRELRRHpreLLLVVGLtAGGTLAFY--TWTTYLQKFLVNTAGFS 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 262 VASSQLYLFLFLGAVAAGTFFGGPIGDRIGRKQV-IWFSILGVA---PFSLLLPHVDLFWTGVLSMVIGFILASAFSAI- 336
Cdd:cd17367 258 KGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLlLFFGIGGTLatvPLLSALDHTDSPYTAFALVLVGLVFLSGYTSIn 337
|
250
....*....|...
gi 1539005408 337 -VVFAqELMPGNV 348
Cdd:cd17367 338 aVVKA-ELFPTHV 349
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
29-349 |
3.95e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 45.33 E-value: 3.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 29 ACALAHLINDLIQAVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLA 108
Cdd:cd17393 3 AVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 109 FVGSFPAILMAA----ALVGIGSSTFHPEASRIARlasggRYGLA-QSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAWF 183
Cdd:cd17393 83 LAPSVPALALALflfgAANGALDVAMNAQGVAVER-----AYGRPiMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 184 GLFAAFAIVVLYGLSRWYRHHLTLFKLKQGGMATHGLSSGRVkfALLILALLVFSKYFYMASFTSYFTFFLIEKFDLSVA 263
Cdd:cd17393 158 AAAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPGFLLPNR--LLLLLGLLALAAALAEGAAADWSALYLRDVLGASAA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 264 SSQLYLFLFLGAVAAGTFFGGPIGDRIGRKQVI-WFSILGVAPFSLLLPHVDLFWTGVLSMVIGFILASAFSAIVVFAQE 342
Cdd:cd17393 236 LAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLrAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGA 315
|
....*..
gi 1539005408 343 LMPGNVG 349
Cdd:cd17393 316 LPGLAAG 322
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
49-204 |
6.34e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.87 E-value: 6.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 49 PMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRH-PKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAALVGIG- 126
Cdd:COG2223 230 PYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIgGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLAl 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 127 ----SSTFHPEASRIARLASGGRYGLAQstfqVGGNAGTAFGPLLAAAIIIPYGQGNVAW--FGLFAAFAIVVLYGLSRW 200
Cdd:COG2223 310 gggnGAVFALVPDIFPTKNAGAVYGLVG----AAGGLGGFLGPLLFGALLDATGSYTAAFlvFAVLALVALVLTLLLYRR 385
|
....
gi 1539005408 201 YRHH 204
Cdd:COG2223 386 PRRA 389
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
49-345 |
7.47e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 44.67 E-value: 7.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 49 PMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAALVGIGSS 128
Cdd:TIGR00881 19 PYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 129 TFHPEASR-IARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAWFG------LFAAFAIVVL------Y 195
Cdd:TIGR00881 99 MGWPPCGRtVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVpgiiaiIVSLICFLLLrdspqsC 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 196 GLSR---WYRHHLTLFKLKQG-GMATHGLSSGRVKFALLI--LALLVFSKYFYMASFTSYFTFFLIEKFDLSVASSQLYL 269
Cdd:TIGR00881 179 GLPPaeeMPNEEPDGDAEKKEeELTKKQIFLQYVLLNKVLwyISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAF 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 270 FLFLGAVAAGTFFGGPIGDRI--GRKQVIWFSILGVAPFSLLL----PHVDLFWTGVLSMVIGFILASAFSAIVVFAQEL 343
Cdd:TIGR00881 259 TLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVywlnPAANPLMDLICLFALGFLVYGPQMLIGVIASEL 338
|
..
gi 1539005408 344 MP 345
Cdd:TIGR00881 339 AP 340
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
29-202 |
9.69e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 44.54 E-value: 9.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 29 ACALAHLINDLIQAVLPAIYPMLKLNYGLSfAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLA 108
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 109 FVGSFPAILMAAALVGIGSSTFHPEASRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAWFGLFAA 188
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGWRWIFYINAI 160
|
170
....*....|....
gi 1539005408 189 FAIVVLYGLSRWYR 202
Cdd:cd06179 161 FNALALILLFFFYH 174
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
56-336 |
1.10e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.07 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 56 GLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLP-AGSLCTLVGILMLAFVGSFPAILMAAALVGIGSSTFHPea 134
Cdd:cd17370 30 GASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLViLGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTP-- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 135 SR---IARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAaIIIPYGQGNV----AWFGLFAAFAIVVLYGLSRWYRHHLTL 207
Cdd:cd17370 108 PRdalLADATPPSGRGKAFGLHRALDTLGAVLGPLLAA-LLLYLLGGNYrtifLLAAIPALLALLILLFVVKEYPRPPKL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 208 FKLKQGGMATHGlsSGRVKFALLILALLVFSKYFYMasftsyFTFFLIEKFDLSVASSQLYLFLFLGAVAAGTFFGGPIG 287
Cdd:cd17370 187 RKKSKKTSLKKL--PKAFWLYLLAVALFALGNFSFA------FLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLS 258
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1539005408 288 DRIGRKQVIWFSILGVAPFSLLLPHVDLFWtgvlSMVIGFILASAFSAI 336
Cdd:cd17370 259 DRIGRKKLLILGYLSLALAYLGFALGSSLW----LLLLGFILWGLYMGA 303
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
5-193 |
1.37e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.72 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 5 PAATPLAGASPVSQASPLVMRVIGACALAHLINDLIQAVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHT 84
Cdd:cd17473 178 RKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLK 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 85 DRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAALVGIGSSTFHPEA-SRIARLASGGRYGLAQSTFQVGGNAGTAF 163
Cdd:cd17473 258 RRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLnSWAMSLVPPELRGRAMGIVTSAFFLGQFL 337
|
170 180 190
....*....|....*....|....*....|
gi 1539005408 164 GPLLAAAIIIPYGQGNVAwFGLFAAFAIVV 193
Cdd:cd17473 338 SPLVLGPLVNLTGGLSGA-FLILGVLALVL 366
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
55-328 |
1.72e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.41 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 55 YGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAALVGIG--SSTFHP 132
Cdd:cd17355 33 FGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGgaGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 133 EASRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYG-QGNVAWFGLFAAFAIVVLYGLSRWYRHHLTLFKLK 211
Cdd:cd17355 113 AFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGwRTALLVLALLALLVLVPVLLLLRRRPADLALRAYD 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 212 QGGMATHGLS----SGRVKFALLILALLV--FSKYFYMASFTSYFTFFLIEKFDLSVASSQLYLFLFLGAVaagtfFGGP 285
Cdd:cd17355 193 DASPASPGSTlkeaLRSASFWLLALAFFLcgFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRL-----LSGW 267
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1539005408 286 IGDRIGRKQV--IWFSILGVAPFSLLLPHVDLFWTGVLSMVIGFI 328
Cdd:cd17355 268 LGDRYSPRRLlaASYALRALGLALLLLLPFPPLALLLFAALFGLG 312
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
53-348 |
2.95e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.59 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 53 LNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAALVGIGSSTFHP 132
Cdd:cd17316 29 FSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 133 EA-SRIARLASGGRYGLAQSTFQVGGNAGTAFGpLLAAAIIIPYGQGNVAWFGLFAAFAIVVLYGLSRWYRhhltlfklk 211
Cdd:cd17316 109 GAsTYVAEFAPSKRRGFALGLLQSGWALGALLA-ALVASLLIPLLSGDWGWRILFLIGALPALLALLLRRR--------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 212 qggmathglssgrvkfaLLILALLVFSKYFYMASFTSYFTFFLIEKFDLSVASSQLYLFLFLGAVAAGTFFGGPIGDRIG 291
Cdd:cd17316 179 -----------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 292 RKQVIWFSILGVAPFSLLL---PHVDLFWTGVLSMVIGFILASAFSAIVVFAQELMPGNV 348
Cdd:cd17316 242 RKKTLVIGLILSGILALPLfylLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEV 301
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
56-395 |
7.34e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 41.38 E-value: 7.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 56 GLSFAQIGLITLTFQLTASLLQPWVGYHTDRH-PKPWLLPAGSLCTLVGILMLAFVGSFPAILMAAALVGIGSSTFHPEA 134
Cdd:cd17471 28 GASPLQIGIFMTLSALSGIVVSQWLGRLSDRGgDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 135 SRIARLA----SGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGqgnVAWFGLFAAFAIVVLYGLSRWYRHHLTlfkl 210
Cdd:cd17471 108 FALAREYadrsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLG---FTGLFLLAALLYLVVALLVLFLLPSVK---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 211 KQGGMATHGLSSGRVKFALLILALLVFSKYFYMASF--TSYFTFFLIEKFDLSVAssqlyLFLFLGAVAAGT-----FFG 283
Cdd:cd17471 181 PPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSmyIIAMPLYVTNELGGSES-----WVGLLFGLAAALeipimLLA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 284 GPIGDRIGRKQVIWFSILGVAPFSLLLphvdLFWTGVLSMVIGFILASAFSAIV-----VFAQELMPGNVGMIAGLFFGL 358
Cdd:cd17471 256 GLLAKRFGKRRLLLAGFLAGVLFYLGL----ALATSLWQLIALQLLNAIFIGITaglgiSYFQDLMPGQPGLATTLYSNA 331
|
330 340 350
....*....|....*....|....*....|....*..
gi 1539005408 359 MFGFGGIGGALLGYLADIHGIEEVFLLCSFLPLLGIL 395
Cdd:cd17471 332 SRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALV 368
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
43-336 |
9.06e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.02 E-value: 9.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 43 VLPAIYPMLK--LNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILMAA 120
Cdd:cd17330 15 VFPVLPFYVRefNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLAR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 121 ALVGIGSSTFHPEASRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAWFGLFAAFAIVVLyglsrw 200
Cdd:cd17330 95 FLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVL------ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 201 yrhhltlfklkqggmathglssgrVKFALLILALLVFSKYFYMASFTSY---FTFFLIEKFDLSVASSQLYLFLF-LGAV 276
Cdd:cd17330 169 ------------------------VLFFLPPLRRLLLVYFLIALAFAGLesvFSLFLKDRFGFSPSQIGLLLALVgIAGI 224
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1539005408 277 AAGTFFGGPIGDRIGRKQVIWFSILGVAPFSLLLPHV-DLFWTGVLSMVIGFILASAFSAI 336
Cdd:cd17330 225 LAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFAsSVPLLVLAAAILAFGTGIVFPAL 285
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
50-310 |
1.17e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 40.75 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 50 MLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVG-SFPAILMAAALVGIGSS 128
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVqSYSVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 129 TFHPEASRIARLASGGRYGLAQSTFQVGGNAGTA----FGPLLAAAIIIPYGQ-GNVAW--------FGLFAAFAIVVLY 195
Cdd:TIGR00886 107 SFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGvaqfVMPPIIGSLIFGGGQpAHLAWgwafvivpAGILLLPALLIFF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 196 GLSRWYRHHLTLFKLKQGGmATHGLSSGRVkfalLILALLVFSKYFYMASFTSYFTFFLIEKFDLSVASSQLYLFL--FL 273
Cdd:TIGR00886 187 VGADTPPGKPATGKLSFKE-ALKVFGNRHT----WILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYASLggFL 261
|
250 260 270
....*....|....*....|....*....|....*..
gi 1539005408 274 GAVAAGTffGGPIGDRIGRKQVIWFSILGVAPFSLLL 310
Cdd:TIGR00886 262 GSLARPA--GGAISDRLGGARKLLMNFLGVAMGAFLV 296
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
39-194 |
2.00e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.85 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 39 LIQAVLPAIYPMLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVGSFPAILM 118
Cdd:cd17477 202 FLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALL 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1539005408 119 AAALV-GIGSSTFHPEA-SRIARLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAIIIPYGQGNVAWFGLFAAFAIVVL 194
Cdd:cd17477 282 VLLFLwGGAAGPLYTLAlALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
50-172 |
2.13e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.85 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 50 MLKLNYGLSFAQIGLITLTFQLTASLLQPWVGYHTDRHPKPWLLPAGSLCTLVGILMLAFVG---SFPAILMAAALVGIG 126
Cdd:cd17321 194 YLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGadsSVWLLLPGLVLLGLG 273
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1539005408 127 SSTFHPEASRIA-RLASGGRYGLAQSTFQVGGNAGTAFGPLLAAAII 172
Cdd:cd17321 274 LGLFATPLTNAAlSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
270-346 |
4.16e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.10 E-value: 4.16e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1539005408 270 FLFLGaVAAGTFFGGPIGDRIGRKQVIWFSILGVAPFSLLLPHVDLFWT-GVLSMVIGFILASAFSAIVVFAQELMPG 346
Cdd:cd17317 33 IFFLG-VLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELfLVLRFLVGVTSAGIFTVGFVLGMEIVGP 109
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
232-400 |
8.69e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 37.78 E-value: 8.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 232 LALLVFSKYFYMASFTSYFTFFLIEKFDLSVASSQLYLFLFLGAVAAGTFFGGPIGDRIGRKQVIWFSILGVAPFSLLL- 310
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005408 311 PHVDLFWTGVLSMVIGFILASAFSAIVVFAQELMPG-NVGMIAGLFFGLMFGFGGIGGALLGYLADIHGIEEVFLLCSFL 389
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|.
gi 1539005408 390 PLLGILTALLP 400
Cdd:pfam07690 161 SLLAAVLLLLP 171
|
|
| |
