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Conserved domains on  [gi|1539005942|ref|WP_125836711|]
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TetR/AcrR family transcriptional regulator [Pseudomonas sp. o96-267]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 10451993)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 57-191 6.17e-30

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


:

Pssm-ID: 433616  Cd Length: 143  Bit Score: 107.72  E-value: 6.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005942  57 FQSEMTPLLDPPAEAQLDVEDYWLFLHLIVERLSQYRFLFQDMSNLAGRLPKLARGIRHWLNALKRTLAALLARLMADGQ 136
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005942 137 LNSGTQALGQLVEQITLTLLFSLDYQRIL-----DQQGEVRLVVYQIMMLVAPHLNQPSR 191
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQRTQapeaaLTEAALRRGVYQVLSLLAPYLTPEGR 140
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
7-53 6.07e-10

Bacterial regulatory proteins, tetR family;


:

Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 52.80  E-value: 6.07e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1539005942   7 ILQTALQLFNEQGEPNVSTLEIANELDISPGNLYYHFHGKEPLVLEL 53
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 57-191 6.17e-30

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


Pssm-ID: 433616  Cd Length: 143  Bit Score: 107.72  E-value: 6.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005942  57 FQSEMTPLLDPPAEAQLDVEDYWLFLHLIVERLSQYRFLFQDMSNLAGRLPKLARGIRHWLNALKRTLAALLARLMADGQ 136
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005942 137 LNSGTQALGQLVEQITLTLLFSLDYQRIL-----DQQGEVRLVVYQIMMLVAPHLNQPSR 191
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQRTQapeaaLTEAALRRGVYQVLSLLAPYLTPEGR 140
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-143 1.33e-19

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 81.48  E-value: 1.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005942   1 MKTRERILQTALQLFNEQGEPNVSTLEIANELDISPGNLYYHFHGKEPLVLELFERFQSEMTPLLDPPAEAQLDVEDYWL 80
Cdd:COG1309     5 EATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLRA 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1539005942  81 FLHLIVERLSQYRFLFQDMSNLAGRLPKLARGIRHWLNALKRTLAALLARLMADGQLNSGTQA 143
Cdd:COG1309    85 LLRAYLEFLAENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALA 147
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
7-53 6.07e-10

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 52.80  E-value: 6.07e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1539005942   7 ILQTALQLFNEQGEPNVSTLEIANELDISPGNLYYHFHGKEPLVLEL 53
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
2-71 2.98e-07

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 48.74  E-value: 2.98e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005942   2 KTRERILQTALQLFNEQGEPNVSTLEIANELDISPGNLYYHFHGKEPLVLELFERfQSEMTPLLDPPAEA 71
Cdd:NF041196    6 RTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE-QVARLREAVEPQRA 74
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 3-64 1.22e-05

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 44.23  E-value: 1.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539005942   3 TRERILQTALQLFNEQGEPNVSTLEIANELDISPGNLYYHFHGKEPLVLELFERFQSEMTPL 64
Cdd:PRK10668   12 TRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWELSESKIGEL 73
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 4-61 4.63e-05

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 42.51  E-value: 4.63e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539005942   4 RERILQTALQLFNEQGEPNVSTLEIANELDISPGNLYYHFHGK----EPLVLELFERFQSEM 61
Cdd:NF037937    1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKqgllEYLVTSFFEGYLEIL 62
 
Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 57-191 6.17e-30

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


Pssm-ID: 433616  Cd Length: 143  Bit Score: 107.72  E-value: 6.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005942  57 FQSEMTPLLDPPAEAQLDVEDYWLFLHLIVERLSQYRFLFQDMSNLAGRLPKLARGIRHWLNALKRTLAALLARLMADGQ 136
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005942 137 LNSGTQALGQLVEQITLTLLFSLDYQRIL-----DQQGEVRLVVYQIMMLVAPHLNQPSR 191
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQRTQapeaaLTEAALRRGVYQVLSLLAPYLTPEGR 140
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-143 1.33e-19

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 81.48  E-value: 1.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005942   1 MKTRERILQTALQLFNEQGEPNVSTLEIANELDISPGNLYYHFHGKEPLVLELFERFQSEMTPLLDPPAEAQLDVEDYWL 80
Cdd:COG1309     5 EATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRERLRA 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1539005942  81 FLHLIVERLSQYRFLFQDMSNLAGRLPKLARGIRHWLNALKRTLAALLARLMADGQLNSGTQA 143
Cdd:COG1309    85 LLRAYLEFLAENPALARLLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALA 147
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
7-53 6.07e-10

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 52.80  E-value: 6.07e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1539005942   7 ILQTALQLFNEQGEPNVSTLEIANELDISPGNLYYHFHGKEPLVLEL 53
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
2-120 3.46e-08

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 51.48  E-value: 3.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005942   2 KTRERILQTALQLFNEQGEPNVSTLEIANELDISPGNLYYHFHGKEPLVLELFERFQSEMTPLLDPPAEAQLDVEDYW-- 79
Cdd:COG3226     8 ERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAea 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1539005942  80 ---LFLHLIVERLSQYRfLFQDMSNLAGRLPKLARGIRHWLNAL 120
Cdd:COG3226    88 ladLLAELLPADRDRLL-ARYELYLEALRDPELRALLRRWRDRL 130
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
2-71 2.98e-07

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 48.74  E-value: 2.98e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1539005942   2 KTRERILQTALQLFNEQGEPNVSTLEIANELDISPGNLYYHFHGKEPLVLELFERfQSEMTPLLDPPAEA 71
Cdd:NF041196    6 RTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE-QVARLREAVEPQRA 74
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 3-64 1.22e-05

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 44.23  E-value: 1.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539005942   3 TRERILQTALQLFNEQGEPNVSTLEIANELDISPGNLYYHFHGKEPLVLELFERFQSEMTPL 64
Cdd:PRK10668   12 TRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWELSESKIGEL 73
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
 4-61 4.63e-05

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 42.51  E-value: 4.63e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1539005942   4 RERILQTALQLFNEQGEPNVSTLEIANELDISPGNLYYHFHGK----EPLVLELFERFQSEM 61
Cdd:NF037937    1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVNVALISYYFKGKqgllEYLVTSFFEGYLEIL 62
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 1-66 1.76e-04

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 40.88  E-value: 1.76e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1539005942   1 MKTRERILQTALQLFNEQGEPNVSTLEIANELDISPGNLYYHFHGKEplvlELFERFQSEMTPLLD 66
Cdd:PRK09975   10 LKTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKT----QLFNEMWLQQPPLRE 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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