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Conserved domains on  [gi|1543103911|ref|WP_126009107|]
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MULTISPECIES: GNAT family N-acetyltransferase [Pseudoalteromonas]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11441181)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
5-145 2.03e-32

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 113.17  E-value: 2.03e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543103911   5 IQIRDAKKSDAPTILQFI-----TELAIYEKEPDAVkTDEQAIIKTLFSEGATAhsVICFEDDEPIGFAvYFYNYSTWLG 79
Cdd:COG1247     2 MTIRPATPEDAPAIAAIYneaiaEGTATFETEPPSE-EEREAWFAAILAPGRPV--LVAEEDGEVVGFA-SLGPFRPRPA 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1543103911  80 KNGLYLEDLYVSPDSRGNGAGKLIMKHLANKAIKNDCGRFEWVVLDWNKPAIDFYNSIGAKAQNEW 145
Cdd:COG1247    78 YRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTL 143
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
5-145 2.03e-32

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 113.17  E-value: 2.03e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543103911   5 IQIRDAKKSDAPTILQFI-----TELAIYEKEPDAVkTDEQAIIKTLFSEGATAhsVICFEDDEPIGFAvYFYNYSTWLG 79
Cdd:COG1247     2 MTIRPATPEDAPAIAAIYneaiaEGTATFETEPPSE-EEREAWFAAILAPGRPV--LVAEEDGEVVGFA-SLGPFRPRPA 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1543103911  80 KNGLYLEDLYVSPDSRGNGAGKLIMKHLANKAIKNDCGRFEWVVLDWNKPAIDFYNSIGAKAQNEW 145
Cdd:COG1247    78 YRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTL 143
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 27-138 4.28e-18

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 74.86  E-value: 4.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543103911  27 IYEKEPDAVKTDEQAIIKTLFSEGATAHSVICFEDDEPIGFAVYFYNYSTWlgkNGLYLEDLYVSPDSRGNGAGKLIMKH 106
Cdd:pfam00583   7 LLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEP---PVGEIEGLAVAPEYRGKGIGTALLQA 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1543103911 107 LANKAIKNDCGRFEWVVLDWNKPAIDFYNSIG 138
Cdd:pfam00583  84 LLEWARERGCERIFLEVAADNLAAIALYEKLG 115
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 55-120 1.51e-09

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 51.12  E-value: 1.51e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1543103911  55 SVICFEDDEPIGFAVYfynYSTWLGKNGLYLEDLYVSPDSRGNGAGKLIMKHLANKAIKNDCGRFE 120
Cdd:cd04301     1 FLVAEDDGEIVGFASL---SPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLR 63
PTZ00330 PTZ00330
acetyltransferase; Provisional
 1-141 1.90e-05

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 42.14  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543103911   1 MSKQIQIRDAKKSDAPTILQFITELAiyekEPDAVKTDEQAIIKTLFSEGATAHSVICFEDDEPI-GFAVYFYNYS-TWL 78
Cdd:PTZ00330    3 MSGSLELRDLEEGDLGSVLELLSHLT----SAPALSQEELEQIAARRRLAGVVTRVFVHSPTQRIvGTASLFVEPKfTRG 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1543103911  79 GKNGLYLEDLYVSPDSRGNGAGKLIMKHLANKAIKNDCGRfewVVLDWNKPAIDFYNSIGAKA 141
Cdd:PTZ00330   79 GKCVGHIEDVVVDPSYRGQGLGRALISDLCEIARSSGCYK---VILDCTEDMVAFYKKLGFRA 138
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
5-145 2.03e-32

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 113.17  E-value: 2.03e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543103911   5 IQIRDAKKSDAPTILQFI-----TELAIYEKEPDAVkTDEQAIIKTLFSEGATAhsVICFEDDEPIGFAvYFYNYSTWLG 79
Cdd:COG1247     2 MTIRPATPEDAPAIAAIYneaiaEGTATFETEPPSE-EEREAWFAAILAPGRPV--LVAEEDGEVVGFA-SLGPFRPRPA 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1543103911  80 KNGLYLEDLYVSPDSRGNGAGKLIMKHLANKAIKNDCGRFEWVVLDWNKPAIDFYNSIGAKAQNEW 145
Cdd:COG1247    78 YRGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTL 143
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 5-152 3.19e-23

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 88.57  E-value: 3.19e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543103911   5 IQIRDAKKSDAPTILQfITELAiyekepdavktdeqAIIKTLFSEGATAHSVICFEDDEPIGFAVYFYnystwLGKNGLY 84
Cdd:COG0454     1 MSIRKATPEDINFILL-IEALD--------------AELKAMEGSLAGAEFIAVDDKGEPIGFAGLRR-----LDDKVLE 60

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1543103911  85 LEDLYVSPDSRGNGAGKLIMKHLANKAIKNDCGRFEWVVLDWNKPAIDFYNSIGAKAQNEWIIYRLAG 152
Cdd:COG0454    61 LKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYERLGFKEIERYVAYVGGE 128
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 27-138 4.28e-18

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 74.86  E-value: 4.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543103911  27 IYEKEPDAVKTDEQAIIKTLFSEGATAHSVICFEDDEPIGFAVYFYNYSTWlgkNGLYLEDLYVSPDSRGNGAGKLIMKH 106
Cdd:pfam00583   7 LLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEP---PVGEIEGLAVAPEYRGKGIGTALLQA 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1543103911 107 LANKAIKNDCGRFEWVVLDWNKPAIDFYNSIG 138
Cdd:pfam00583  84 LLEWARERGCERIFLEVAADNLAAIALYEKLG 115
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 66-156 2.76e-15

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 66.99  E-value: 2.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543103911  66 GFAVYFYNYstwlGKNGLYLEDLYVSPDSRGNGAGKLIMKHLANKAIKNDCGRFEWVVLDWNKPAIDFYNSIGAKAQNEW 145
Cdd:COG0456     1 GFALLGLVD----GGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGER 76

                          90
                  ....*....|.
gi 1543103911 146 IIYRLAGQDLL 156
Cdd:COG0456    77 PNYYGDDALVM 87
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
7-147 1.19e-14

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 66.65  E-value: 1.19e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543103911   7 IRDAKKSDAPTILQfITELAIyekepdaVKTDEQAIIKTLFSEGATAHSVICFEDDEPIGFAVyFYNYSTWLGKNGLYLE 86
Cdd:COG3153     1 IRPATPEDAEAIAA-LLRAAF-------GPGREAELVDRLREDPAAGLSLVAEDDGEIVGHVA-LSPVDIDGEGPALLLG 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1543103911  87 DLYVSPDSRGNGAGKLIMKHLANKAIKNDCGRfewVVLDWNKPAIDFYNSIGAKAQNEWII 147
Cdd:COG3153    72 PLAVDPEYRGQGIGRALMRAALEAARERGARA---VVLLGDPSLLPFYERFGFRPAGELGL 129
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 5-138 2.98e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 62.70  E-value: 2.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543103911   5 IQIRDAKKSDAPTILQFITELAIYEKEPDAVktdeqaiiktlfsegatahsvICFEDDEPIGFAVYFYnystwLGKNGLY 84
Cdd:COG1246     1 MTIRPATPDDVPAILELIRPYALEEEIGEFW---------------------VAEEDGEIVGCAALHP-----LDEDLAE 54

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1543103911  85 LEDLYVSPDSRGNGAGKLIMKHLANKAIKNDCGRfewVVLDWNKPAIDFYNSIG 138
Cdd:COG1246    55 LRSLAVHPDYRGRGIGRRLLEALLAEARELGLKR---LFLLTTSAAIHFYEKLG 105
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 55-120 1.51e-09

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 51.12  E-value: 1.51e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1543103911  55 SVICFEDDEPIGFAVYfynYSTWLGKNGLYLEDLYVSPDSRGNGAGKLIMKHLANKAIKNDCGRFE 120
Cdd:cd04301     1 FLVAEDDGEIVGFASL---SPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLR 63
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 43-144 2.62e-09

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 52.27  E-value: 2.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543103911  43 IKTLFSEGATaHSVICFEDDEPIGFAvyfynySTwlgKNGLYLEDLYVSPDSRGNGAGKLIMKHLANKAIKNDCGRFEwV 122
Cdd:pfam13673  22 LRERIDQGEY-FFFVAFEGGQIVGVI------AL---RDRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSE-L 90

                          90       100
                  ....*....|....*....|..
gi 1543103911 123 VLDWNKPAIDFYNSIGAKAQNE 144
Cdd:pfam13673  91 TVNASPYAVPFYEKLGFRATGP 112
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 53-138 5.75e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 50.15  E-value: 5.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543103911  53 AHSVICFEDDEPIGFAVYFYNYstwlGKNGLYLEDLYVSPDSRGNGAGKLIMKHLANKAIKNDCGRFEwvvLDWNKPAID 132
Cdd:pfam13508   3 GRFFVAEDDGKIVGFAALLPLD----DEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLE---LETTNRAAA 75


                  ....*.
gi 1543103911 133 FYNSIG 138
Cdd:pfam13508  76 FYEKLG 81
PTZ00330 PTZ00330
acetyltransferase; Provisional
 1-141 1.90e-05

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 42.14  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543103911   1 MSKQIQIRDAKKSDAPTILQFITELAiyekEPDAVKTDEQAIIKTLFSEGATAHSVICFEDDEPI-GFAVYFYNYS-TWL 78
Cdd:PTZ00330    3 MSGSLELRDLEEGDLGSVLELLSHLT----SAPALSQEELEQIAARRRLAGVVTRVFVHSPTQRIvGTASLFVEPKfTRG 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1543103911  79 GKNGLYLEDLYVSPDSRGNGAGKLIMKHLANKAIKNDCGRfewVVLDWNKPAIDFYNSIGAKA 141
Cdd:PTZ00330   79 GKCVGHIEDVVVDPSYRGQGLGRALISDLCEIARSSGCYK---VILDCTEDMVAFYKKLGFRA 138
PRK10514 PRK10514
putative acetyltransferase; Provisional
 60-106 7.59e-03

putative acetyltransferase; Provisional


Pssm-ID: 182510 [Multi-domain]  Cd Length: 145  Bit Score: 34.98  E-value: 7.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1543103911  60 EDDEPIGFAVYfynystwlgkNGLYLEDLYVSPDSRGNGAGKLIMKH 106
Cdd:PRK10514   57 ERDQPVGFMLL----------SGGHMEALFVDPDVRGCGVGRMLVEH 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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