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Conserved domains on  [gi|1543104215|ref|WP_126009411|]
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MULTISPECIES: type VI secretion system-associated protein TagF [unclassified Pseudoalteromonas]

Protein Classification

type VI secretion system-associated protein( domain architecture ID 10008130)

type VI secretion system-associated protein similar to Pseudomonas Aeruginosa protein Pa0076

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SciT COG3913
Regulator of T6SS expression TagF, TagF/ImpM/SciT family (unrelated to teichoic acid ...
 7-227 8.46e-57

Regulator of T6SS expression TagF, TagF/ImpM/SciT family (unrelated to teichoic acid polymerase TagF of B.subtilis, COG1887) [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 443118  Cd Length: 222  Bit Score: 180.26  E-value: 8.46e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543104215   7 NIGYLGKVPSLGDFVQDSVSKEFSEHWEQWLQAAIAVSKEQLGDNWQDNYLTGPVWHFALSPNIVGDKGVMGTLLPSMDA 86
Cdd:COG3913     2 RIGWFGKLPSRGDFVRRRLPRALIAAWDRWLQQGLAASREQLGPRWLDLYLTAPIWRFALPPGVGGEQAVAGVLMPSVDR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543104215  87 VGRHYPFTVASTLEVA---PIEVLNSGVFSLEYEDTVLKVLDSSVDLFTWrkdvAKSISTLIAPKKQLSISPSSDKNKEG 163
Cdd:COG3913    82 VGRYFPLTVAAALPADeplPFPLALARLWFEQLEAAALAALRDGADAEQL----LQALAALPPPLLADPAAILALLGDFL 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1543104215 164 EAFEFSGDELSSD-VLKDTLHALLYKKHGDYSVWWTHGSCNIKPMMLVTSGLPPVNQVAAMLDGR 227
Cdd:COG3913   158 ETQTLESLEADLAaAWRQLLLALLLQPVAATSLWWTSGSDGVPPRTLLHLGLPDPALFAALLAGL 222
 
Name Accession Description Interval E-value
SciT COG3913
Regulator of T6SS expression TagF, TagF/ImpM/SciT family (unrelated to teichoic acid ...
 7-227 8.46e-57

Regulator of T6SS expression TagF, TagF/ImpM/SciT family (unrelated to teichoic acid polymerase TagF of B.subtilis, COG1887) [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443118  Cd Length: 222  Bit Score: 180.26  E-value: 8.46e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543104215   7 NIGYLGKVPSLGDFVQDSVSKEFSEHWEQWLQAAIAVSKEQLGDNWQDNYLTGPVWHFALSPNIVGDKGVMGTLLPSMDA 86
Cdd:COG3913     2 RIGWFGKLPSRGDFVRRRLPRALIAAWDRWLQQGLAASREQLGPRWLDLYLTAPIWRFALPPGVGGEQAVAGVLMPSVDR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543104215  87 VGRHYPFTVASTLEVA---PIEVLNSGVFSLEYEDTVLKVLDSSVDLFTWrkdvAKSISTLIAPKKQLSISPSSDKNKEG 163
Cdd:COG3913    82 VGRYFPLTVAAALPADeplPFPLALARLWFEQLEAAALAALRDGADAEQL----LQALAALPPPLLADPAAILALLGDFL 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1543104215 164 EAFEFSGDELSSD-VLKDTLHALLYKKHGDYSVWWTHGSCNIKPMMLVTSGLPPVNQVAAMLDGR 227
Cdd:COG3913   158 ETQTLESLEADLAaAWRQLLLALLLQPVAATSLWWTSGSDGVPPRTLLHLGLPDPALFAALLAGL 222
TagF_N pfam09867
TagF N-terminal domain, Type VI secretion system-associated; This is the N-terminal domain of ...
 9-103 1.45e-41

TagF N-terminal domain, Type VI secretion system-associated; This is the N-terminal domain of the T6S-associated protein, TagF. A post-translational repressor of the hemolysin co-regulated secretion island I (HSI-I)-encoded type VI secretion system (H1-T6SS) found in Pseudomonas aeruginosa. The type VI secretion system (T6SS) is found broadly among the Proteobacteria and is implicated in diverse processes including host-cell interactions, biofilm formation and gene regulation. Furthermore, studies indicate that the T6SS plays a critical role in interbacterial interactions. TagF has been shown to regulate the activity of the H1-T6SS in a manner that does not require phosphorylated-Fha1, PpkA, or other Tag proteins. Additionally TagF is found to associate as a homodimer with nearly identical monomers composed of alpha and beta elements assembled as a three-layer sandwich (alpha-beta-alpha).


Pssm-ID: 430892  Cd Length: 135  Bit Score: 138.51  E-value: 1.45e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543104215   9 GYLGKVPSLGDFVQDSVSKEFSEHWEQWLQAAIAVSKEQLGDNWQDNYLTGPVWHFALSPNIVGDKGVMGTLLPSMDAVG 88
Cdd:pfam09867   1 GWFGKLPARGDFVSRRLPRAFLAAWDDWLQAGLAASRQRLGDAWLDAYLTAPPWRFALPPGLGGRQAWAGVLMPSVDRVG 80

                          90
                  ....*....|....*
gi 1543104215  89 RHYPFTVASTLEVAP 103
Cdd:pfam09867  81 RYFPLTLAAALPADA 95
VI_minor_4 TIGR03373
type VI secretion-associated protein, BMA_A0400 family; Members of this protein family are ...
 9-125 7.59e-38

type VI secretion-associated protein, BMA_A0400 family; Members of this protein family are found exclusively, although not universally, in bacterial species that possess a type VI secretion system. Genes are found in type VI secretion-associated gene clusters. The specific function is unknown. This model represents the rather well-conserved amino-terminal domain of a protein family in which carboxy-terminal regions, when present, show little conservation. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 132416  Cd Length: 136  Bit Score: 128.99  E-value: 7.59e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543104215   9 GYLGKVPSLGDFVQDSVSKEFSEHWEQWLQAAIAVSKEQLGDNWQDNYLTGPVWHFALSPNIVGDKGVMGTLLPSMDAVG 88
Cdd:TIGR03373   1 GYFGKLPARGDFVKRALPHQFAQPWDRWLQAGLAASRQQLGDDWKDAYLTAPVWRFALAPGARGGQALAGVLIPSRDRVG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1543104215  89 RHYPFTVASTLEVAPI---EVLNSGVFSLEYEDTVLKVLD 125
Cdd:TIGR03373  81 RYFPLTVAAALPAAAPltfLLLSPDAWFGQVEALLLSSLD 120
 
Name Accession Description Interval E-value
SciT COG3913
Regulator of T6SS expression TagF, TagF/ImpM/SciT family (unrelated to teichoic acid ...
 7-227 8.46e-57

Regulator of T6SS expression TagF, TagF/ImpM/SciT family (unrelated to teichoic acid polymerase TagF of B.subtilis, COG1887) [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443118  Cd Length: 222  Bit Score: 180.26  E-value: 8.46e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543104215   7 NIGYLGKVPSLGDFVQDSVSKEFSEHWEQWLQAAIAVSKEQLGDNWQDNYLTGPVWHFALSPNIVGDKGVMGTLLPSMDA 86
Cdd:COG3913     2 RIGWFGKLPSRGDFVRRRLPRALIAAWDRWLQQGLAASREQLGPRWLDLYLTAPIWRFALPPGVGGEQAVAGVLMPSVDR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543104215  87 VGRHYPFTVASTLEVA---PIEVLNSGVFSLEYEDTVLKVLDSSVDLFTWrkdvAKSISTLIAPKKQLSISPSSDKNKEG 163
Cdd:COG3913    82 VGRYFPLTVAAALPADeplPFPLALARLWFEQLEAAALAALRDGADAEQL----LQALAALPPPLLADPAAILALLGDFL 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1543104215 164 EAFEFSGDELSSD-VLKDTLHALLYKKHGDYSVWWTHGSCNIKPMMLVTSGLPPVNQVAAMLDGR 227
Cdd:COG3913   158 ETQTLESLEADLAaAWRQLLLALLLQPVAATSLWWTSGSDGVPPRTLLHLGLPDPALFAALLAGL 222
TagF_N pfam09867
TagF N-terminal domain, Type VI secretion system-associated; This is the N-terminal domain of ...
 9-103 1.45e-41

TagF N-terminal domain, Type VI secretion system-associated; This is the N-terminal domain of the T6S-associated protein, TagF. A post-translational repressor of the hemolysin co-regulated secretion island I (HSI-I)-encoded type VI secretion system (H1-T6SS) found in Pseudomonas aeruginosa. The type VI secretion system (T6SS) is found broadly among the Proteobacteria and is implicated in diverse processes including host-cell interactions, biofilm formation and gene regulation. Furthermore, studies indicate that the T6SS plays a critical role in interbacterial interactions. TagF has been shown to regulate the activity of the H1-T6SS in a manner that does not require phosphorylated-Fha1, PpkA, or other Tag proteins. Additionally TagF is found to associate as a homodimer with nearly identical monomers composed of alpha and beta elements assembled as a three-layer sandwich (alpha-beta-alpha).


Pssm-ID: 430892  Cd Length: 135  Bit Score: 138.51  E-value: 1.45e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543104215   9 GYLGKVPSLGDFVQDSVSKEFSEHWEQWLQAAIAVSKEQLGDNWQDNYLTGPVWHFALSPNIVGDKGVMGTLLPSMDAVG 88
Cdd:pfam09867   1 GWFGKLPARGDFVSRRLPRAFLAAWDDWLQAGLAASRQRLGDAWLDAYLTAPPWRFALPPGLGGRQAWAGVLMPSVDRVG 80

                          90
                  ....*....|....*
gi 1543104215  89 RHYPFTVASTLEVAP 103
Cdd:pfam09867  81 RYFPLTLAAALPADA 95
VI_minor_4 TIGR03373
type VI secretion-associated protein, BMA_A0400 family; Members of this protein family are ...
 9-125 7.59e-38

type VI secretion-associated protein, BMA_A0400 family; Members of this protein family are found exclusively, although not universally, in bacterial species that possess a type VI secretion system. Genes are found in type VI secretion-associated gene clusters. The specific function is unknown. This model represents the rather well-conserved amino-terminal domain of a protein family in which carboxy-terminal regions, when present, show little conservation. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 132416  Cd Length: 136  Bit Score: 128.99  E-value: 7.59e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1543104215   9 GYLGKVPSLGDFVQDSVSKEFSEHWEQWLQAAIAVSKEQLGDNWQDNYLTGPVWHFALSPNIVGDKGVMGTLLPSMDAVG 88
Cdd:TIGR03373   1 GYFGKLPARGDFVKRALPHQFAQPWDRWLQAGLAASRQQLGDDWKDAYLTAPVWRFALAPGARGGQALAGVLIPSRDRVG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1543104215  89 RHYPFTVASTLEVAPI---EVLNSGVFSLEYEDTVLKVLD 125
Cdd:TIGR03373  81 RYFPLTVAAALPAAAPltfLLLSPDAWFGQVEALLLSSLD 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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