|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
17-394 |
2.46e-74 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 236.39 E-value: 2.46e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 17 IGMSLLAICYTMIIPFLPVYLLELGV-EQEQLAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLW 95
Cdd:cd17391 3 LGNFFTGIGFSLIAPFLPLYIEQLGVtSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 96 SAFVQDEYQFLLVRAFQGFANGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGI 175
Cdd:cd17391 83 MAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 176 TLFIVTAAIAIFVKEpQMESETPVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAML 255
Cdd:cd17391 163 LLFLAFLLTLFFVKE-DFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 256 AGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVN 335
Cdd:cd17391 242 SGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKI 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1547460756 336 TDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGiGMMIIGYLVLKIH 394
Cdd:cd17391 322 TPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTA-LLVLLNAIWSFIF 379
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
17-378 |
4.93e-48 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 168.56 E-value: 4.93e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 17 IGMSLLAICYTMIIPFLPVYLLELGVE-QEQLAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLW 95
Cdd:PRK09874 21 LGCFLTGAAFSLVMPFLPLYVEQLGVTgHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 96 SAFVQDEYQFLLVRAFQGFANGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGI 175
Cdd:PRK09874 101 MGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITAS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 176 TLFIVTAAIAIFVKEpQMESETPVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAML 255
Cdd:PRK09874 181 VLFLCFLVTLFCIRE-NFQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGNVSNIAFI 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 256 AGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVN 335
Cdd:PRK09874 260 SGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYN 339
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1547460756 336 TDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLV 378
Cdd:PRK09874 340 SSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLV 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-385 |
5.28e-43 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 154.27 E-value: 5.28e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 15 LTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYL 94
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQI----GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 95 WSAFVQDEYQFLLVRAFQGFANG-FMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVA 173
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 174 GITLFIVTAAIAIFVKEPQMESET-PVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELkgsMEGA 252
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKrAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAEL---GGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 253 AMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAM 332
Cdd:cd17325 234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1547460756 333 TVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMI 385
Cdd:cd17325 314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-356 |
2.83e-34 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 130.09 E-value: 2.83e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 1 MKGLQQTGMVAVWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKL 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA----GLVVTAYLLGAALGAPLAGRLADRFGRRR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 81 MAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQGFANG-FMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGL 159
Cdd:COG2814 77 VLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 160 TELAVGMRPVFMVAGITLFIVTAAIAIFVKEPQmesetPVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVA 239
Cdd:COG2814 157 LADLFGWRWVFLVNAVLALLALLLLLRLLPESR-----PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 240 IYVGELKGSmegAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGV 319
Cdd:COG2814 232 LYLQEVLGL---SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGF 308
|
330 340 350
....*....|....*....|....*....|....*..
gi 1547460756 320 FIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGN 356
Cdd:COG2814 309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-391 |
5.42e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 116.52 E-value: 5.42e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 9 MVAVWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGIL 88
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL----GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 89 IGLSYLWSAFVQDEYQFLLVRAFQGFANGFM-PAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMR 167
Cdd:COG2223 80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSfAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 168 PVFMVAGITLFIVTAAIAIFVKEPQmESETPVKTTSFSEDLQAAKQNKVLLhILGLYFLVQAVMLMLQPIVAIYvgeLKG 247
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPP-AGAAAAAKASLRDQLEALRDPRFWL-LSLLYFGTFGSFIGFSSWLPPY---LVD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 248 SMEGAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFG-LWWFGALQLLIGVFIVGIFP 326
Cdd:COG2223 235 QFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGNG 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1547460756 327 SLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVL 391
Cdd:COG2223 315 AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLT 379
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
13-393 |
1.48e-25 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 106.55 E-value: 1.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 13 WILTIGMSLLAICYTMIIPFLPVYLLELGveqeQLAIWSGLSFSISFFIAAIMAPVWGRLADQHGKK-----LMAIRAGI 87
Cdd:cd06173 2 RLLWLAQLLSALGDWIFTVALPWLVLQLT----GSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrllilADLLRALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 88 LIGLSYLWSAFVQDEYQFLLVRAFQGFANGF-MPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGM 166
Cdd:cd06173 78 AAVLALLALLGSLSLWLLLVLAFLLGIASAFfGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 167 RPVFMVAGITLFIVTAAIAI--FVKEPQMESETPVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGE 244
Cdd:cd06173 158 GGAFAINALSFLLSALLLLFirRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 245 LKGSMEGAAMLAGSILSGGGVMGMIMTNVWaayGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGI 324
Cdd:cd06173 238 VLGGGAAGYGLLLAAFGVGALLGALLLGRL---SKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLF 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1547460756 325 FPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVLKI 393
Cdd:cd06173 315 NVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-360 |
5.19e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 101.73 E-value: 5.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 15 LTIGMSLLAICYTMIIPFLPVYLLE-LGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSY 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEdLGISPTEI----GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 94 LWSAFVQDEYQFLLVRAFQGFANG-FMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMV 172
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 173 AGITLFIVTAAIAIFVKEPQMESETPVKTtsfSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGA 252
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEE---ARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 253 AMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFR---VISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLG 329
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALN 313
|
330 340 350
....*....|....*....|....*....|.
gi 1547460756 330 SAMTVNTDPSVRGRVFGLATTSQQLGNMIGP 360
Cdd:pfam07690 314 ALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
12-390 |
5.60e-24 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 101.86 E-value: 5.60e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 12 VWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQlaiwSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGL 91
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQ----AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 92 SYLWSAFVQDEYQFLLVRAFQGFANG-FMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVF 170
Cdd:cd17324 77 GNLLAALAPSFALLLLARALAGLAHGgFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 171 MVAGITLFIVTAAIAIFVkePQMESETPVKTTSFSEdLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYvgeLKGSME 250
Cdd:cd17324 157 LAIAVLALLAALLLWRLL--PSLPPKKPGSLGLLSS-LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPF---LTDVPG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 251 GAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLgS 330
Cdd:cd17324 231 FSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSAL-Q 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 331 AMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVaGIGMMIIGYLV 390
Cdd:cd17324 310 TRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWV-GAALLLLALLL 368
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-391 |
1.28e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 100.96 E-value: 1.28e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 15 LTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYL 94
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQL----GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 95 WSAFVQDEYQFLLVRAFQGFANG-FMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGL--TELAVGMRPVFM 171
Cdd:cd06174 77 LFAFAPSFWLLLLGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIlaSSLGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 172 VAGITLFIVTAAIAIFVKEPQ---MESETPVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGS 248
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPesaRAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 249 MEGAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLlqSLPFGLWWFGALQLLIGVFIVGIFPSL 328
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALL--LLAPSLLLLLLLLLLLGFGLGGLLPLS 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1547460756 329 GSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVL 391
Cdd:cd06174 315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
10-391 |
5.00e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 99.17 E-value: 5.00e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 10 VAVWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILI 89
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQL----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 90 GLSYLWSAFVQDEYQFLLVRAFQGFANG-FMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRP 168
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 169 VFMVAGITLFIVTAAiaifvkepqmesetpvkttsfsedlqaakqnkVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGS 248
Cdd:COG2271 166 AFLILGLPGLLLALL--------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 249 MEGAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPfGLWWFGALQLLIGVFIVGIFPSL 328
Cdd:COG2271 214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFGLGGAFGLL 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1547460756 329 GSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVL 391
Cdd:COG2271 293 WALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
12-393 |
1.91e-22 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 97.68 E-value: 1.91e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 12 VWILTIGMSLLAICYTMIIPFLPVYLLElgvEQEQLAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGL 91
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQ---QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 92 SYLWSAFVQDEYQFLLVRAFQGFANG-FMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTeLAVGMRPVF 170
Cdd:cd17329 78 GFALLGFAHSPWLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 171 MVAGITLFIVTAAIAIFVKEPQMESETPVKtTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGsme 250
Cdd:cd17329 157 LAAAVLFLLAALVLLFLLPETRPKRRAAEK-TEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILG--- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 251 GAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGS 330
Cdd:cd17329 233 LGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQT 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1547460756 331 AMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVLKI 393
Cdd:cd17329 313 LVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
28-381 |
1.54e-21 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 94.97 E-value: 1.54e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 28 MIIPFLPVYLLELGveqeQLAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLL 107
Cdd:cd17489 14 LLLPVLPLYAHDLG----GSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 108 VRAFQGFANG-FMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIvTAAIAI 186
Cdd:cd17489 90 LRLIHGIGWGaFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL-ALLLVF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 187 FVKEPQMESETPVKTTSFSedLQAAKQNKVLLHILGLyFLVQAVMLMLQPIVAIYVGELKGSMEGAAMLAGSILSgggvm 266
Cdd:cd17489 169 LVKDPPPVAAEEAEAGTRA--FRRLVEKKVLPPALIL-FLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIAL----- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 267 gMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFG 346
Cdd:cd17489 241 -LLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANG 319
|
330 340 350
....*....|....*....|....*....|....*
gi 1547460756 347 LATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGI 381
Cdd:cd17489 320 TFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAV 354
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
27-393 |
4.19e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 91.09 E-value: 4.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 27 TMIIPFLPVYLLELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFL 106
Cdd:cd17474 16 SIVDPILPAIAEALGASPAQV----GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 107 LVRAFQGFAN-GFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTeLAVGMRPVFMVAGITLFIVTAAIA 185
Cdd:cd17474 92 AGRALQGIGAaGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 186 IFVKEPQMESETPVKTTSFseDLQAAKQNKVLLHILG---LYFLVQAVMLMLQPIVAIYVGELKGSMEGAAMLAGSILsg 262
Cdd:cd17474 171 FLLPEPKEKAKSSSATKLR--DLKKALRGRGLLTFLVsafLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVL-- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 263 ggvmgMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPF--GLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSV 340
Cdd:cd17474 247 -----LALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFvpSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEE 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1547460756 341 RGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVLKI 393
Cdd:cd17474 322 RGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
15-392 |
3.23e-19 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 88.02 E-value: 3.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 15 LTIGMSLLAICYTMIIPFLPVYLLELGVEQEQlAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYL 94
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGAS-GYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 95 WSAFVQDEYQFLLVRAFQGFANGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAG 174
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 175 ITLFIVTAAIAIFVKepqmesetpvkttsfsedlqaakqnkVLLHILGLYFLVQAVMLMLQPIVAIYvgeLKGSMEGAAM 254
Cdd:cd17330 160 ALALLNLVLVLFFLP--------------------------PLRRLLLVYFLIALAFAGLESVFSLF---LKDRFGFSPS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 255 LAGSILSGGGVMGMIMtnVWAAYGQRRGYF---RVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSA 331
Cdd:cd17330 211 QIGLLLALVGIAGILA--QLLLIPRLAKRLgerKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSAL 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1547460756 332 MTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVLK 392
Cdd:cd17330 289 LSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-188 |
2.60e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.71 E-value: 2.60e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 11 AVWILTIGMSLLAICYTMIIPFLPVYLLELGVEQeqlAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIG 90
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS---PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 91 LSYLWSAFVQDEYQFLLVRAFQGFANGFM-PAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPV 169
Cdd:cd17325 277 VALLLLPLATSFWLLLLLLALLGLGLGLVfPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356
|
170
....*....|....*....
gi 1547460756 170 FMVAGITLFIVTAAIAIFV 188
Cdd:cd17325 357 FLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
12-179 |
4.96e-18 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 85.01 E-value: 4.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 12 VWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGL 91
Cdd:cd17391 203 LISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 92 SYLWSAFVQDEYQFLLVRAFQGFANG-FMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVF 170
Cdd:cd17391 283 LYIPQAFVQTPWQLGILRFLLGLATGgLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVF 362
|
....*....
gi 1547460756 171 MVAGITLFI 179
Cdd:cd17391 363 VVTALLVLL 371
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
27-393 |
7.30e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 81.47 E-value: 7.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 27 TMIIPFLPVYLLELGVEqeqlAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFL 106
Cdd:cd17504 13 TMLSPALPTIQREFGTS----AAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 107 LVRAFQGFANGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIVTAAIAI 186
Cdd:cd17504 89 AGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 187 FvkepqmesetpvkttsfseDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAMLAGSILSGGGVM 266
Cdd:cd17504 169 I-------------------DLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 267 GMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSL-PFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVF 345
Cdd:cd17504 230 MLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALlHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIAT 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1547460756 346 GLATTSQQLGNMIGPLFASIVATYW-------------GTSYVFLVAGIGMMIIGYLVLKI 393
Cdd:cd17504 310 GMNTVLRTIGSAIGPAIAGAILTTYtvsitsggvptegAYVLAFLIGAALALAALLLSLLI 370
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
48-391 |
1.48e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 80.31 E-value: 1.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 48 AIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQGFANG-FMPAAMTMV 126
Cdd:cd17473 34 ELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAgIMTLATALI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 127 SLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTeLAVGMRPVFMVAGItLFIVTAAIAIFVKEPQMESETPVKTTSFSE 206
Cdd:cd17473 114 GDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVYLL-ALPVLILVLLFLPEPARKSKSAASPGAATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 207 dlqAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGsmeGAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRV 286
Cdd:cd17473 192 ---AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGG---GSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 287 ISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPL-FASI 365
Cdd:cd17473 266 LAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLvLGPL 345
|
330 340
....*....|....*....|....*.
gi 1547460756 366 VATYWGTSYVFLVAGIGMMIIGYLVL 391
Cdd:cd17473 346 VNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
52-392 |
8.45e-16 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 78.05 E-value: 8.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 52 GLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQGFANG-FMPAAMTMVSLSV 130
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGsVQPGGGRAIMRWF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 131 PKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIVTAAIAIFVKEPQMESETPVKTTSFSEDLQA 210
Cdd:cd17475 114 PPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLKE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 211 AKQNKVLLHIL---GLYFLVQAVMLMLqpiVAIYVGELKGSMEGAAMLAGSILSGGGVMGMIMTNVWAAY---GQRRGYF 284
Cdd:cd17475 194 VLRNRDVWLIAiagALLVAPQFALLTF---LLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRvfgGRRRPVL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 285 RVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGP-LFA 363
Cdd:cd17475 271 VITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPpLFG 350
|
330 340
....*....|....*....|....*....
gi 1547460756 364 SIVATYWGTSYVFLVAGiGMMIIGYLVLK 392
Cdd:cd17475 351 LLVDATHSYAPAWLALA-LLLVLAALLLL 378
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
12-187 |
6.66e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 72.24 E-value: 6.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 12 VWILTIGMSLLAICYTMIIPFLPVYLLELGVEQeqlaiwSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGL 91
Cdd:cd17489 196 VLPPALILFLASIAYGAISTFLPLYAAERGISN------AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLAL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 92 SYLWSAFVQDEYQFLLVRAFQGFANG-FMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVF 170
Cdd:cd17489 270 GLLLLSFAGSPWMLLLAAVLYGLGFGlLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMF 349
|
170
....*....|....*..
gi 1547460756 171 MVAGItlfIVTAAIAIF 187
Cdd:cd17489 350 LLAAV---VVLLALVLY 363
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
15-391 |
1.77e-13 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 71.04 E-value: 1.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 15 LTIGMSLLAICYTMIIPFLPVYLL-ELGVEQEQLAIwsglsFSISFFIAAIMAPVW-GRLADQHGKKLMAIRAGILIG-L 91
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTeELGASPLQIGI-----FMTLSALSGIVVSQWlGRLSDRGGDRKPLILLALLAGaL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 92 SYLWSAFVQDEYQFLLVRA-FQGFANGFMPAAMTM---VSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMR 167
Cdd:cd17471 76 GYLLFAFLRNYWVLLLVGVvLLSLGAAAFPQLFALareYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 168 PVFMVAGITLFIVTAAIAIFVKEPQmeseTPVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGElkg 247
Cdd:cd17471 156 GLFLLAALLYLVVALLVLFLLPSVK----PPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTN--- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 248 SMEGAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIvGIFPS 327
Cdd:cd17471 229 ELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFI-GITAG 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1547460756 328 LGsaMTVNTDpSVRGRVfGLATT----SQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVL 391
Cdd:cd17471 308 LG--ISYFQD-LMPGQP-GLATTlysnASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-371 |
5.55e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 69.93 E-value: 5.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 12 VWILTIGMSLLAICYTMIIPFLPVYLL-ELGVEqeqlAIWSGLSFSISFFIAAIMAPVWGRLADQ----HGKKLMAIRAG 86
Cdd:COG2211 12 KLAYGLGDLGLNLAFGLLSAYLLYFYTdVLGLS----AALVGLILLVARLWDAITDPLIGALSDRtrtrWGRRRPWILIG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 87 -ILIGLSY--LWSAFVQDE-----YQFLLVRAFQGFANGFMPAAMTMVS-LSVPKERVGTAMGIFQMGLVLGNTVGPLTG 157
Cdd:COG2211 88 aIPLALSFvlLFTAPDLSPtgkliYALVTYLLLGLAYTLVNIPYSALGAeLTPDYEERTRLSSWRFAFAGLGGLLASVLP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 158 GL------TELAVGMRPVFMVAGITLFIVTAAIAIFVKEPQMESETPVkttSFSEDLQAAKQNKVLLHILGLYFLVQAVM 231
Cdd:COG2211 168 PPlvaafgGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV---SLKESLKALLKNRPFLLLLLAYLLFFLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 232 LMLQPIVAIYVGELKGSMEGAAMLAGSILSGGGVMGMIMTNVWAA-YGQRRGYFrvISYGLLGTGTVLLLQSLPFGLWWF 310
Cdd:COG2211 245 ALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKrFGKKKAFI--IGLLLAALGLLLLFFLGPGNLWLL 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1547460756 311 GALQLLIGVFIVGIFPSLGSAMT-------VNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWG 371
Cdd:COG2211 323 LVLAALAGIGLGAILVLPWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-287 |
5.79e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 69.07 E-value: 5.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 9 MVAVWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGIL 88
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL----GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 89 IGLSYLWSAFVQDEYQFLLVRAFQGFANGFM-PAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMR 167
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGGLmPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 168 PVFMVAGItLFIVTAAIAIFVKEPQMESETPVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKG 247
Cdd:COG0477 169 WIFLINAP-LGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1547460756 248 SMEGAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVI 287
Cdd:COG0477 248 LALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLL 287
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
5-399 |
5.95e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.50 E-value: 5.95e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 5 QQTGMVAVWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIR 84
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQA----GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 85 AGILIGLSYLWSAFVQDEYQFLLVRAFQGFANGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGL---TE 161
Cdd:COG0738 79 GLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLlilLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 162 LAVGMRPVFMVAGItLFIVTAAIAIFVKEPQMESETPVKTTSFSEDLQAAKQNKVLLHILGLYFLVqAVMLMLQPIVAIY 241
Cdd:COG0738 159 LSLSWHLPYLILAV-LLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYV-GAEGAIGDWLPLY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 242 VGELKGSMEGAAMLAGSILSGGGVMGMIMTNVWAAygqRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFI 321
Cdd:COG0738 237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLK---RFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1547460756 322 VGIFPSLGSAmTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVLKIHGNRPN 399
Cdd:COG0738 314 SLMFPTIFSL-ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
46-280 |
6.86e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 69.57 E-value: 6.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 46 QLAIWSGLSFSISFfiaAIMAPVWGRLADQHG-KKLMAIraGILI-GLSYLWSAFVQDEYQFLLVRAFQGFAN-GFMPAA 122
Cdd:cd17328 34 SLAGLLQTVFIISY---MVLSPIFGYLGDRYNrKWILAV--GILIwSAATLLSSFAPNFWQLLLFRALVGIGEaSYSPIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 123 MTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGL-TELAVGMRPVFMVAGITLFIVTAAIAIFVKEPQ-----MESE 196
Cdd:cd17328 109 PTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLvAQATGGWRWAFRVTGVLGVLLAILLLLFVREPPrgaaeGGVM 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 197 TPVKTTSFSEDLQAAKQNKVLLHIL--------GLYFLVQAVMLMLQpiVAIYVGELKGSMEGAAMLAGSILSG--GGVM 266
Cdd:cd17328 189 AKSTATSFLADLKALAKNPSFILSTlgftavsfVTGALAFWAPTFFL--RAFGVGDLSSADVGLIFGAITCIAGvlGVLL 266
|
250
....*....|....
gi 1547460756 267 GMIMTNVWAAYGQR 280
Cdd:cd17328 267 GGILADRLRRKTPR 280
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
12-385 |
1.20e-12 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 68.72 E-value: 1.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 12 VWILTIGMSLLAICYTMIIPFLPVYLLELGVEqeqlAIWSGLSFSISFFIAAIMAPVWGRLADQHGK-KLMAIRAGILIG 90
Cdd:cd17370 1 VWLLGLVSLFADISYEMARSILPLFLVVLGAS----AAAVGLIEGLAEALGSLLRLFSGYLSDRTGKrKPLVILGYGLSA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 91 LSYLWSAFVQDEYQFLLVRAFQGFANGFM-PAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPL--TGGLTELAVGMR 167
Cdd:cd17370 77 LAKPLLALAGSWQLVLLLRILERLGKGIRtPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLlaALLLYLLGGNYR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 168 PVFMVAGITLFIVTAAIAIFVKEPqmesETPVKTTSFSEDLQAAKQNKVLLHILGLYFL--------------VQAVMLM 233
Cdd:cd17370 157 TIFLLAAIPALLALLILLFVVKEY----PRPPKLRKKSKKTSLKKLPKAFWLYLLAVALfalgnfsfaflilrAQELGLS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 234 LQPIVAIYVgelkgsmegAAMLAGSILSGggVMGMImtnvwaayGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGAL 313
Cdd:cd17370 233 AALIPLLYA---------LFNLVYALAAY--PAGRL--------SDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLG 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1547460756 314 QLLIGVFIvGIFPSLGSAMTVN-TDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMI 385
Cdd:cd17370 294 FILWGLYM-GAQESIERAAVADlVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
11-187 |
6.65e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.44 E-value: 6.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 11 AVWILTIGMSLLAICYTMIIPFLPVYLLELGVeqeQLAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIG 90
Cdd:cd17473 198 RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGG---GSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMA 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 91 LSYLWSAFVQDEYQFLLVRAFQGFANGF-MPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPL-TGGLTELAVGMRP 168
Cdd:cd17473 275 LGFLLLALASGLWVVLLGAILAGLGFGLlLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLvLGPLVNLTGGLSG 354
|
170
....*....|....*....
gi 1547460756 169 VFMVAGITLFIVTAAIAIF 187
Cdd:cd17473 355 AFLILGVLALVLAIVLLLL 373
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
26-391 |
8.45e-11 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 63.25 E-value: 8.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 26 YTMIIPFL-PVYL---LELGVEQEQLAIWsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQD 101
Cdd:COG2270 26 STVITTFVfPPYFtsvAALGDPAAATALW-GYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATAALFFVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 102 EYQFLLVRAFQGFANGFMPAAMT-----MVSLSVPKER-----VGTAMG----IFQMGLVLGNTVGPLTGGLTELAVGMR 167
Cdd:COG2270 105 PGGLWLGLLLFVLANIGFEGSLVfynafLPDIATPEEIgrvsgLGWALGylggVLLLLINLALFLKPEAFGLPDAGEAVR 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 168 PVFMVAGITLFIVTAAIAIFVKEPQMESETPVK---TTSFSE---DLQAAKQNKVLLHILGLYFL----VQAVMLMlqpi 237
Cdd:COG2270 185 ISFLLTALWWLLFALPLFLFLPERPRPGPAPPRgavRAGFRElrrTLRELRRYRDLLRFLLAYFFyrdgVQTVIAF---- 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 238 VAIYvgelkgsmeGAAMLAgsiLSGGGVMGM-IMTNVWAAYG--------QRRGYFRVISYGLLGTGTVLLLQSLPFGLW 308
Cdd:COG2270 261 AGIY---------AAGVLG---FSTTELIVFgLLVQIVAALGallfgrldDRIGPKRVILVSLVIWIVVCLAAYFLTTAL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 309 WFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGY 388
Cdd:COG2270 329 AFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGL 408
|
...
gi 1547460756 389 LVL 391
Cdd:COG2270 409 VLL 411
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
13-367 |
1.18e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 62.76 E-value: 1.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 13 WILTIGMSLLAICY----TMIIPF-LPVYLLELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGI 87
Cdd:TIGR00895 15 QWRAIILSFLIMLMdgydLAAMGFaAPAISAEWGLDPVQL----GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 88 LIGLSYLWSAFVQDEYQFLLVRAFQGFA-NGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGM 166
Cdd:TIGR00895 91 LFSVFTLLCALATNVTQLLILRFLAGLGlGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 167 RPVFMVAGITLFIVTAAIAIFVKEP-------------------------------QMESETPVKTTSFSEDLQAAKQNK 215
Cdd:TIGR00895 171 RSLFYVGGIAPLLLLLLLMRFLPESidflvskrpetvrrivnaiapqmqaeaqsalPEQKSTQGTKRSVFKALFQGKTAR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 216 VLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAmLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTG 295
Cdd:TIGR00895 251 ITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAA-TGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAV 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1547460756 296 TVLLLQSLPFGLWWFGAlqlLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVA 367
Cdd:TIGR00895 330 LVGSTLFSPTLLLLLGA---IAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
11-392 |
1.45e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 62.20 E-value: 1.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 11 AVWILTIGMSLLAICY----TMIIPFLPVYLLELGVEqeqlAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAG 86
Cdd:COG2807 15 GRWLLLLAIVLVALNLrpaiTSVGPLLPEIRADLGLS----ATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLAL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 87 ILIGLSYLWSAFVQDEYQFLLVRAFQGFANGFMPAAMT-MVSLSVPKeRVGTAMGIFQMGLVLGNTVGPLTGGLTELAVG 165
Cdd:COG2807 91 LLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPgLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 166 MRPVFMVAGITLFIVTAAIAIFVKEPQMESETPVKTTSFSEDLQAAkqnkvLLHILGLYFLVQAVML--MLQPIVAIYVg 243
Cdd:COG2807 170 WRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSP-----LAWLLTLFFGLQSLLYyaVVAWLPPILR- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 244 elkgSMEGAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLllqslPFGLWWFGALQLLIGVFIVG 323
Cdd:COG2807 244 ----DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAG-----LLGLLLAPGSLPWLWAVLLG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1547460756 324 I----FPSLGSAMTVN--TDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTS----YVFLVAGIGMMIIGYLVLK 392
Cdd:COG2807 315 LgqggLFPLALTLIGLraRTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWtaalLLLAALAVLMLVAGLLAGR 393
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-368 |
2.21e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 61.81 E-value: 2.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 15 LTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLaIWSGLSFSISFfiaAIMAPVWGRLADQHGKKLMAIRAGILIGLSYL 94
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQL-QWVVNAYLLAF---AALLLLAGRLGDRFGRKRVFLIGLALFGLASL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 95 WSAFVQDEYQFLLVRAFQGF-ANGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVA 173
Cdd:cd17321 77 LCALAPSLAFLIAARALQGIgAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 174 GITLFIVTAAIAIFVkepqmesetpvkTTSFSedlqaakqnkvllhiLGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAA 253
Cdd:cd17321 157 VPIGLVALLLARTFS------------GAVLA---------------AFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 254 MLAGSIlsgggvMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFgaLQLLIGVFIVGI-----FPSL 328
Cdd:cd17321 210 LLPLAL------AMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSV--WLLLPGLVLLGLglglfATPL 281
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1547460756 329 GSAMTVNTDPSVRGRVFGLATTSQQLGNMIGP-LFASIVAT 368
Cdd:cd17321 282 TNAALSSVPKEKAGAASGILNTARQLGGALGVaLLGALLTA 322
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
21-391 |
3.49e-10 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 61.08 E-value: 3.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 21 LLAICYTMIIPFLPVYLLELGVEqeqlAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQ 100
Cdd:cd17331 11 LYATCYWLQQPVLPYLTKKLGVD----SVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 101 DEYQFLLVRAFQGFANGFMPAAMTMVSLSVPKERVGtAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIV 180
Cdd:cd17331 87 SVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAA-ALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 181 TAAIAIFVKEPQMESETPVKTTSFSEDLQAA-KQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGE---LKGSMEGAAMLA 256
Cdd:cd17331 166 IVLVILLIPSNTKSKREKEAKESASPPSVFNlKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFslvAMDFFGLTPEEN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 257 GSILSGGGVMGMIMTNVWAAY-GQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVN 335
Cdd:cd17331 246 GYLMSYAGVLGMVVQGLLVGPlTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKA 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1547460756 336 TDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWG-TSYVFLVAGIGMMIIGYLVL 391
Cdd:cd17331 326 VPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGfPSFGLLGAAINGLLTVYLLL 382
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
52-363 |
1.09e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 59.59 E-value: 1.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 52 GLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQGFA-NGFMPAAMTMVSLSV 130
Cdd:PRK11551 53 GWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGlGGALPNLIALTSEAV 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 131 PKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIVTAAIAIFVKEPQM---ESETPVKTTSFSED 207
Cdd:PRK11551 133 GPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAfaqAAGAGKQRAPVLRA 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 208 LQAAKQNKVLLHILGLYFLVQAVMLMLQ---PIVAIYVGeLKGSMEGAAMLAGSILSGGG--VMGMIMtnvwaaygQRRG 282
Cdd:PRK11551 213 LFGEGRATATLLLWISYFFTLIVLYFLLnwlPSLLVGQG-LSRSQAGLVQIAFNIGGALGslLIGALM--------DRLR 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 283 YFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLF 362
Cdd:PRK11551 284 PRRVVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLL 363
|
.
gi 1547460756 363 A 363
Cdd:PRK11551 364 A 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-190 |
1.43e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 59.11 E-value: 1.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 8 GMVAVWILTIGMSLLAICYTMIIPFLPVYLLE-LGVEQEQlaiwSGLSFSISFFIAAIMAPVWGRLADQHGK--KLMAIR 84
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQ----AGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAI 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 85 AGILIGLSYLWSAFVQDEYQFLLVRAFQGFA-NGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELA 163
Cdd:COG2271 254 GLLLAALALLLLALLPSPALAIALLFLAGFGlGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333
|
170 180
....*....|....*....|....*..
gi 1547460756 164 VGMRPVFMVAGITLFIVTAAIAIFVKE 190
Cdd:COG2271 334 TGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
52-387 |
2.31e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 58.35 E-value: 2.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 52 GLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQGFAN-GFMPAAMTMVSLSV 130
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEaGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 131 PKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIVTAAIAIFVkepqmesetpvkttsfsedlqa 210
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL---------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 211 akqnKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKG-SMEGAAMLAgSILSGGGVMGMIMTNVWAAYGQRRGYFRVISY 289
Cdd:cd17319 179 ----RQVWGLALGYFGINYALYGLLTWLPTYLKQARGfSLKQVGLLA-AIPFLAGAIGMILGGRLSDRLLRGARRLVIII 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 290 GLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATY 369
Cdd:cd17319 254 GLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDA 333
|
330
....*....|....*...
gi 1547460756 370 WGTSYVFLVAGIGMMIIG 387
Cdd:cd17319 334 TGSYTAAFLFLAAVALLA 351
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
56-374 |
2.36e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 58.74 E-value: 2.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 56 SISFFIA-AIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQGFANGFM-PAAMTMVSLSVPKE 133
Cdd:cd17503 37 ITSYLLAlAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLiPLAQTILLRIYPPE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 134 RVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFmvagitLFIVTAAIAIFVKEPQMesetpvkttsfseDLQAAKQ 213
Cdd:cd17503 117 KRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF------YINLPIGILALLLAPLL-------------DLRLFKD 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 214 NKVLLHILgLYFLVQAVMLMLQPIVAIYVGELKGSmegAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISY---G 290
Cdd:cd17503 178 RNFTLGLL-LSFLLGLGLFGAMFLLPLYLQNVLGY---SAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAgllL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 291 LLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYW 370
Cdd:cd17503 254 LALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNR 333
|
....
gi 1547460756 371 GTSY 374
Cdd:cd17503 334 TQFH 337
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
33-381 |
4.09e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 57.60 E-value: 4.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 33 LPVYLLELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQ 112
Cdd:cd17365 22 APALAQDWGLSPAQL----GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 113 GFA-NGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIVTAAiaifvkep 191
Cdd:cd17365 98 GLGlGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL-------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 192 qmesetpVKTTsfsedlqaakqnkvlLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAMLaGSILSGGGVMGMIMT 271
Cdd:cd17365 170 -------LRGT---------------LLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTI-TLLLNIGGVIGSLLL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 272 NvWAAygQRRGYFRVISYGLLGTGTVLLLQSL-PFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATT 350
Cdd:cd17365 227 G-WLA--DRFGPKRVLALFFALGAVSLALLGVsPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALG 303
|
330 340 350
....*....|....*....|....*....|..
gi 1547460756 351 SQQLGNMIGPLFA-SIVATYWGTSYVFLVAGI 381
Cdd:cd17365 304 VGRLGAILGPLLGgLLLAAGLGPESVFLALAI 335
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
48-391 |
4.19e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 57.61 E-value: 4.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 48 AIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQGFA-NGFMPAAMTMV 126
Cdd:cd17316 35 LLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGiGGEYPGASTYV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 127 SLSVPKERVGTAMGIFQM----GLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIVTAAiaifvkepqmesetpvktt 202
Cdd:cd17316 115 AEFAPSKRRGFALGLLQSgwalGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLL------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 203 sfsedlqaakqNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAMLAGSILSGGGVMGMImtnVWAAYGQRRG 282
Cdd:cd17316 176 -----------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGAL---IAGLLSDRIG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 283 YFR--VISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGP 360
Cdd:cd17316 242 RKKtlVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAP 321
|
330 340 350
....*....|....*....|....*....|.
gi 1547460756 361 LFASIVATYWGTSYVFLVAGIGMMIIGYLVL 391
Cdd:cd17316 322 PLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
17-179 |
4.20e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 57.62 E-value: 4.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 17 IGMSLLAICYTMI-----IPFLPVYLLELGVEQEQLAIWSGLSFSISFFIAAIMAPVWGRLadqHGKKLMAIRAGILIGL 91
Cdd:cd17490 197 LFFSLLAILQQMItfsttFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKK---LGERNTIIIGFLLLGA 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 92 SYLWSAFVQDEYQFLLVRAFQGFANGFM-PAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVF 170
Cdd:cd17490 274 YCFLIPFAPNLTLLYLLQALNGFGTGILfPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGF 353
|
....*....
gi 1547460756 171 MVAGITLFI 179
Cdd:cd17490 354 FVIGVIALL 362
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
15-383 |
4.68e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 57.57 E-value: 4.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 15 LTIGMSLLAICYTMIIPFLPVYLLELGVEqeqlAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYL 94
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVS----TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 95 WSAFVQDEYQFLLVRAFQGFANGFMPAAM-TMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAvGMRPVFMVA 173
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALPFLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 174 GITLFIVTAAIAIFVKEPQMESETPVKTtsfsedLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGelkGSMEGAA 253
Cdd:cd17477 156 VLLLLALVPLLLTRRAAPEIEEAESISL------RRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLG---LSVAQAA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 254 MLAGSILSGGGVMGMIMTnvWAAygQRRGYFRVI-SYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAM 332
Cdd:cd17477 227 LLLAAFVLGGLLLQWPLG--WLA--DRFDRRRVLlGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALA 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1547460756 333 TVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGM 383
Cdd:cd17477 303 GDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVA 353
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
63-347 |
6.06e-09 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 57.33 E-value: 6.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 63 AIMAPVWGRLADQHGKKLM-----AIRAGILIGLSYLWSAFVQDEYQFLLVRAFQGFANGF-MPAAMTMVSLSVPKERVG 136
Cdd:TIGR00900 48 VVLSPIAGALADRYDRKKVmigadLIRAVLVAVLPFVALLGGLNIWQVYVLAGILAIAQAFfTPAYQAMLPDLVPEEQLT 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 137 TAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITlFIVTAAIAIFVKEPQMESETPVKTTS-----FSEDLQAA 211
Cdd:TIGR00900 128 QANSLSQAVRSLFYIVGPGIGGLMYATLGIKWAIWVDAVG-FAISALLIVSVRIPELAASEIQALSNavlrdTREGIKFV 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 212 KQNKVLLHILGLYFLVQAVMLMlqPIVAIYVGELKGSMEGAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGL 291
Cdd:TIGR00900 207 LKNPLLRTLLLLALLFNLVFAP--AIVALFPYVQSKYLGRGSTHYGWVLAAFGLGALLGALLLGLLGRYFKRMALMTGAI 284
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1547460756 292 LGTGTVLLLQSLPFGLWW-FGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGL 347
Cdd:TIGR00900 285 FVIGLAILVVGLTPPNFPlFLVLWFAIGVGYGPINVPQGTLLQRRVPAELLGRVFGA 341
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
28-391 |
6.72e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 57.18 E-value: 6.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 28 MIIPFLPVYLLELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLL 107
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQA----GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 108 VRAFQGFANG-FMPAAMTMVSLsVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIVtaAIAI 186
Cdd:cd17478 90 LVALAGIGSAaFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAV--ALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 187 FVKEPQMESETPVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAMLAGSILSGGGVM 266
Cdd:cd17478 167 LRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 267 GMIMtnvwAAYGQRRGYFRVISYGLLGTGTVLLLqSLPFGLWWFGALQLLIGVFIVGIFPSLGsAMTVNTDPSVRGRVFG 346
Cdd:cd17478 247 TLIG----GPLSDRFGRRRVIIASLLLAAPFLLL-FLLTPGIWSYILLVLAGFLLFASFPVTV-VLAQELLPGNVGLASG 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1547460756 347 LATT-SQQLGNMIGPLFASIvATYWGTSYVFLVAGIGMMIIGYLVL 391
Cdd:cd17478 321 LMMGlSFGLGGIGAPVLGAL-ADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
30-391 |
8.59e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 56.85 E-value: 8.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 30 IPFLPVYLLELGVEQEQLAIWSGlSFSISFFIAAImaPVwGRLADQHGKKLMAIRAGILI-GLSYLWSAFVQDEYQFLLV 108
Cdd:cd17490 16 VPFLSPYAESLGASLSMIGIILG-AYGISQMLLRI--PL-GILSDRIGKRKLFIIIGLLFtVLASLIMILFPSPWGLLIA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 109 RAFQGFANGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAgITLFIVTAAIAIFV 188
Cdd:cd17490 92 RFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLA-ALAGVLGFILSLFI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 189 KEPQMESETpvKTTSFSEDLQAAKQNKVLlhilgLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAMLAGSILSgggvMGM 268
Cdd:cd17490 171 KEERREKKP--VLTELKELLSVLKDKKLL-----FFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLS----IIY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 269 IMTNVWAAY------GQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRG 342
Cdd:cd17490 240 LLPNALASLlsgtlfYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRS 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1547460756 343 RVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVL 391
Cdd:cd17490 320 TAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSL 368
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-152 |
2.66e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.98 E-value: 2.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 11 AVWILTIGMSLLAICYTMIIPFLPVYLLE-LGVEQEQlaiwSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILI 89
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASA----AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1547460756 90 GLSYLWSAFVQDEYQFLLVRAFQGFANGF-MPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTV 152
Cdd:COG2814 284 ALGLLLLALAGSLWLLLLALFLLGFGFGLlFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
14-381 |
3.41e-08 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 54.89 E-value: 3.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 14 ILTIGMSLLAICYTMIIPFLPVYLlelgveQEQLAIwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSY 93
Cdd:cd17384 4 IVYVALLLDNMLLTVVVPIIPDYL------NENVRV--GLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFIST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 94 LWSAFVQdEYQFLLV-RAFQGFANGF-MPAAMTMVSLSVP--KERvGTAMGIFQMGLVLGNTVGPLTGG-LTELAVGMRP 168
Cdd:cd17384 76 LLFAFGE-SYGVLFLaRALQGVGSACsSVAGMGMLASLYPddKER-GKAMGIALGGLALGVLVGPPFGGvMYEFVGKSAP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 169 VFMVAGITLFIVtaAIAIFVKEPQMESETPVKTTSFSEDLqaakQNKVLLHILGLYFLVQAVMLMLQPIVAIYvgeLKGS 248
Cdd:cd17384 154 FLILAFLALLDG--ALQLFILQPSVKSEESEEGTPWKTLL----KDPYILIAAGAICFSNSGIAILEPCLPIW---MMET 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 249 ME------GAAMLAGSILSgggvmgMIMTNVWAAYGQRRGyfRVISYGLLGTGTVLLLQSLPFGLWWFG------ALQLL 316
Cdd:cd17384 225 MCppkwqlGTAFLPDSIGY------LIGTNLFGPLAHKIG--RWLCSLLGMLLVGISLILIPLAKNIYGliiphfGLGLG 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1547460756 317 IGVFIVGIFPSLGSAMTVNtDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGI 381
Cdd:cd17384 297 IGMVDSSMMPLLAYLVDLR-HSSVYGSVYAIADVAFCLAFALGPSLGGAIVKSIGFPWLMRIIGI 360
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
32-387 |
6.60e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 54.23 E-value: 6.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 32 FLPVYLLELGVEQEQLAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAF 111
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 112 QGFA-NGFMPAAMTMVSLSVPKERVGTAMGIFQM----GLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIVtAAIAI 186
Cdd:cd17371 97 AGLGfGGEWAAGAALMAEYVPARHRGKALGYVQSgwavGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLV-LFIRR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 187 FVKEPQMESETPVKTTSF-SEDLQAAKQNKVLLHILGLYFLVQAVMLM-----LQPIVAIYVGELKGSMEGAAMLAGSIL 260
Cdd:cd17371 176 FVKEPPQWQAARAARRHFaDRPSLRELFSPPLLRTTLLASLLATGALGgyygiTTWLPSYLTGERGLSFEGSAGYLVVTI 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 261 SgGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFgaLQLLIGVFIVGIFPSLGSAMTVNTDPSV 340
Cdd:cd17371 256 L-GGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILI--LGFPLGFFASGPFSGMGAYLTELFPTAV 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1547460756 341 RGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIG 387
Cdd:cd17371 333 RATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAG 379
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
218-392 |
9.66e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.44 E-value: 9.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 218 LHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTV 297
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 298 LLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFL 377
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170
....*....|....*
gi 1547460756 378 VAGIGMMIIGYLVLK 392
Cdd:COG2814 169 VNAVLALLALLLLLR 183
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
51-390 |
1.10e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 53.38 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 51 SGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFV-QDEYQFLLVRAFQGFANGFMPAAMTMVSLS 129
Cdd:cd17353 40 VALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAiSLPLLFLGYGVLGGIGAGIGYITPVSTAVK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 130 VPKERVGTAMGIFQMGLVLGNTV-GPLTGGLTElAVGMRPVFMVAGITLFIVTAAIAIFVKEPQmESETPVKTTSFSEDL 208
Cdd:cd17353 120 WFPDKRGLATGIVIAGFGLGSLIfSPLIAYLIN-TVGVPTTFLILGIIFLIIIVIGAFLIRDPP-KGWVPPGVDPLANNA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 209 QAAKQN---------KVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAMLAGSILSgggVMGMIMTNVWAAYGQ 279
Cdd:cd17353 198 ENSPRDytpremlrtPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILS---IFNGGGRPFWGWLSD 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 280 RRGYFRVISYGLLGTGTVLLLQSL-PFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMI 358
Cdd:cd17353 275 KIGRKNTLSIAFLIQGVAMFLLPFiGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLI 354
|
330 340 350
....*....|....*....|....*....|..
gi 1547460756 359 GPLFASIVATYWGTSYVFLVAGIgMMIIGYLV 390
Cdd:cd17353 355 GPIIAAYVLYTGGYNAAFIIAAA-LSLVALAL 385
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
50-391 |
1.20e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 53.43 E-value: 1.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 50 WSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQGF--ANGFMPAAMTMVS 127
Cdd:cd17355 39 VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGggAGTLAAVAFATVA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 128 LSVPKERVGTAMGIFQMGLVLGNTVG-PLTGGLTElAVGMRPVF-MVAGITLFIVTAAIAIFVKEP---QMESETPVKTT 202
Cdd:cd17355 119 AWWFERRRGLALGILTAGGGLGSLVFlPLGAALIE-AFGWRTALlVLALLALLVLVPVLLLLRRRPadlALRAYDDASPA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 203 SFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSmegaAMLAGSILSGGGVMGMIMTNVWAAYGQRRG 282
Cdd:cd17355 198 SPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGIS----PAAAAVALALIGLFNIVGRLLSGWLGDRYS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 283 --YFRVISYGLLGTGTVLLLQSLPFGLWWFGALqLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGP 360
Cdd:cd17355 274 prRLLAASYALRALGLALLLLLPFPPLALLLFA-ALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGP 352
|
330 340 350
....*....|....*....|....*....|.
gi 1547460756 361 LFASIVATYWGTSYVFLVAGIGMMIIGYLVL 391
Cdd:cd17355 353 WLGGLLYDRTGSYTAAWALAVALGLIAALLV 383
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
29-192 |
1.76e-07 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 52.85 E-value: 1.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 29 IIPFLPVYL-LELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLL 107
Cdd:COG2270 257 VIAFAGIYAaGVLGFSTTEL----IVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWI 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 108 VRAFQGFANGFMPAA-MTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIVTAAIAI 186
Cdd:COG2270 333 LGLLIGLVMGGIQALsRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGLVLLL 412
|
....*.
gi 1547460756 187 FVKEPQ 192
Cdd:COG2270 413 RVKVPR 418
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
12-391 |
2.41e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 52.19 E-value: 2.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 12 VWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLAiwsgLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGL 91
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQ----LTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 92 SYLWSAFVQDEYQFLLVRAFQGF-ANGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVF 170
Cdd:cd17320 77 ASLLCALASSIEQLLIARFLQGLgAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 171 MVAGITLFIVTAAIAIFVKEPQ-MESETPVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSM 249
Cdd:cd17320 157 VFLALLGLLLLLLVLLFLPETLpEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 250 EGAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSL-PFGLWWFGALQLLIGVFIVGIFPSL 328
Cdd:cd17320 237 AQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLgGLSLWPLVAPLFLIFFGFGLIFPNA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1547460756 329 gSAMTVNTDPSVRGRVFGLATTSQqlgNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVL 391
Cdd:cd17320 317 -TSLALEPFPHVAGTASALLGFLQ---FLIGALAGALVGLLPNGTALPMGLLILVLGLLALLL 375
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-190 |
2.56e-07 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 49.57 E-value: 2.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 52 GLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQGFANGF-MPAAMTMVSLSV 130
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFaLVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 131 PKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIVTAAIAIFVKE 190
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
14-195 |
3.90e-07 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 52.00 E-value: 3.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 14 ILTIGMSL---LAICYTMIIPF-LPVYLLELGVEQEQLAiWSGLSFSISffiAAIMAPVWGRLADQHGKKLMAIRAGILI 89
Cdd:TIGR00711 2 LLTIVLMLgtfMAVLDSTIVNVaIPTIAGDLGSSLSQVQ-WVITSYMLA---NAISIPLTGWLAKRFGTRRLFLISTFAF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 90 GLSYLWSAFVQDEYQFLLVRAFQGFANGFM-PAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRP 168
Cdd:TIGR00711 78 TLGSLLCGVAPNLELMIIFRVIQGFGGGPLiPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRW 157
|
170 180 190
....*....|....*....|....*....|
gi 1547460756 169 VFMV---AGITLFIVTAAIAIFVKEPQMES 195
Cdd:TIGR00711 158 IFLInvpIGIIVVVVAFFILPRDKPAASEN 187
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
13-189 |
4.46e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.83 E-value: 4.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 13 WILTIGMSLLAICYTMIIPFLPVYLLE-LGVEQEqlaiWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGL 91
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFKYvLGLSAA----LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 92 SYLWSAFVQ--DEYQFLLVRAFQGFANG-FMPAAMTMVSLSVP-------KERVGTAMGIFQMGLVLGNTVGPLTGGL-- 159
Cdd:COG2211 307 GLLLLFFLGpgNLWLLLVLAALAGIGLGaILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLll 386
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1547460756 160 ------------TELAVGMRPVFMVAGITLFIVTAAIAIFVK 189
Cdd:COG2211 387 alfgyvagaaqsPSALTGIRLLFFLLPAVLLLLAALLLLFYP 428
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
210-391 |
1.54e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.87 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 210 AAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISY 289
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 290 GLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATY 369
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180
....*....|....*....|..
gi 1547460756 370 WGTSYVFLVAGIGMMIIGYLVL 391
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRF 182
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
11-153 |
1.58e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 49.86 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 11 AVWILTIGMSLLAICYTMIIPFLPVYLLELgveQEQLAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIG 90
Cdd:cd17321 169 TFSGAVLAAFLLGAALGGLLFLLPLYLQGV---LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTA 245
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1547460756 91 LSYLWSAFV---QDEYQFLLVRAFQGFANGF-MPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVG 153
Cdd:cd17321 246 VGLLLLALLgadSSVWLLLPGLVLLGLGLGLfATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
14-193 |
1.82e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 49.57 E-value: 1.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 14 ILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLAiWSGLSFSISF--FIAaimapVWGRLADQHGKKLMAIRAGILIGL 91
Cdd:cd17476 2 TISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLS-WLAASYSLTVgtFIL-----IFGRLGDIYGHKKMFVIGSFWFAI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 92 SYLWSAFVQDEYQFLLVRAFQGFANGFM-PAAMTMVSLSVPK-ERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPV 169
Cdd:cd17476 76 WSLIAGFSPNFIFFIICRALQGLGPAFLlPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWI 155
|
170 180
....*....|....*....|....
gi 1547460756 170 FMVAGITLFIVtAAIAIFVKEPQM 193
Cdd:cd17476 156 FWFLAILAAIV-AVAAIFWTSPSF 178
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
28-386 |
1.98e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 49.52 E-value: 1.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 28 MIIPFLPVYLLELgveQEQLAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLL 107
Cdd:cd17472 14 LVLPVLSVYAKSL---PGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 108 VRAFQGfANGFMPAAMTMVSLSVPKERVGTAMGIfqMGLVLGNT--VGPLTGGLTELAVGMRPVFMVAGITLFIVTAAIA 185
Cdd:cd17472 91 GRALQG-SGAISSVVMALLADLTREENRTKAMAL--IGASIGIAfaISMVLGPLLAAHLGVSGLFLITAILSLVSLLILL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 186 IFVKEPQmesETPVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAML-AGSILSGGG 264
Cdd:cd17472 168 FFVPDPP---KIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVyLPAILIGFI 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 265 VMGMIMtnvwaAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIF--PSLGSAMTVNTDPSVRG 342
Cdd:cd17472 245 LMVPFV-----IYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLleALLPSLVSKIAPKEYRG 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1547460756 343 RVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMII 386
Cdd:cd17472 320 TAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLW 363
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
28-366 |
3.84e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 48.40 E-value: 3.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 28 MIIPFLPVYLLELGVEQEQLAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLL 107
Cdd:cd17388 17 LIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 108 VRAFQGFANG-FMPAAMTMVSLSVPKERVGtAMGIFQMGLVLGNTVGPLTGGLTElAVGMRPVFMVAGItLFIVTAAIAI 186
Cdd:cd17388 97 GRIIAGITGAtGAVAAAYIADVTPPEQRAR-NFGLLGAAFGLGFIAGPALGGLLG-EISPRAPFLVAAG-LNGLNFLLGL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 187 FV----KEPQMESETPVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKG--SMEGAAMLAGSIL 260
Cdd:cd17388 174 FVlpesLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDwsPTMVGLSLAVFGL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 261 SGGGVMGMIMTNVWAAYGQRRG-YFRVISYGLLGTGTVLLLQslpfGLWWFGALQLLIGVFIVGifPSLGSAMTVNTDPS 339
Cdd:cd17388 254 LHALFQAFVTGPIAKRLGEKRAiLLGLAADALGFLLLAFATQ----GWMVFPILILLALGGIAG--PALQGLLSRQVPEN 327
|
330 340
....*....|....*....|....*..
gi 1547460756 340 VRGRVFGLATTSQQLGNMIGPLFASIV 366
Cdd:cd17388 328 EQGELQGVLTSLTSLTSIIGPLLFTGI 354
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
220-391 |
4.25e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.18 E-value: 4.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 220 ILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAMLAGSILSGGGVMGMImtnVWAAYGQRRGYFRVISYGLLGTGTVLL 299
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQP---LAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 300 LQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVA 379
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170
....*....|..
gi 1547460756 380 GIGMMIIGYLVL 391
Cdd:pfam07690 158 AILSLLAAVLLL 169
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
27-190 |
9.87e-06 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 47.18 E-value: 9.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 27 TMIIPFLPVYLLELGVEQEQlaiwSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFL 106
Cdd:cd17323 16 SIYSPALPQIAEDFHVSEEV----ANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 107 LVRAFQGFangFMPAAMTMVSLSV----PKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIVTA 182
Cdd:cd17323 92 ILRFLQGF---FGSSPLAIGAGTIadlfTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLI 168
|
....*...
gi 1547460756 183 AIAIFVKE 190
Cdd:cd17323 169 LIFLFLPI 176
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
307-398 |
1.08e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 47.27 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 307 LWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMII 386
Cdd:cd17312 91 LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVV 170
|
90
....*....|..
gi 1547460756 387 GYLVLKIHGNRP 398
Cdd:cd17312 171 AIILFFFLRDSP 182
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
62-180 |
1.51e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 46.40 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 62 AAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQGF-ANGFMPAAMTMVSLSVPKERVGTAMG 140
Cdd:cd17502 43 STAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIgGGGLMSLAFIIIADLVPPRERGKYQG 122
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1547460756 141 IFQMGLVLGNTVGPLTGGLTELAVGMRPVFM----VAGITLFIV 180
Cdd:cd17502 123 YIGAVFGIASVAGPLIGGAFTDHLSWRWCFYinlpIGGLALALL 166
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
28-381 |
1.55e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 46.45 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 28 MIIPFLPVYLLELGVEQEQLAIWSGLSFSISFFiaaiMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLL 107
Cdd:cd17390 14 MILPLLSTHIRSLGASPTVIGLIGSVYGALQLF----SSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 108 VRAFQGFANGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGG-LTELAVGMRPVFMVAGITLFIVTAAIAI 186
Cdd:cd17390 90 SRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGhLAETDGGFYYVALLCSAIFILNAGLVWF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 187 FVKEpqmesetpvkttsfsedlqaakqnkvLLHILGLYFLVQAVMLMLQPIVAIYvgeLKGSMEGAAMLAGSILSGGGVM 266
Cdd:cd17390 170 LLSK--------------------------LWDLLLVRFLMGFSVLLFRSNFSLY---LEERFDLSPKTIGYLISYSGVL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 267 GMIM----TNVWAAYGQRrgYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIgVFIVGIFPSLGSAMTV-NTDPSVR 341
Cdd:cd17390 221 GALSgflvGRILKLYKNN--EYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPL-SISSAVLRTCSTSLLLsRGKSKER 297
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1547460756 342 GRVFGLATTSQQLGNMIGPLFASIVATyWGTSYVFLVAGI 381
Cdd:cd17390 298 GTLLGVGQSVTSLARILAPLLSGLLQE-FSVSGPGLLGAV 336
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
27-184 |
1.58e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.40 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 27 TMIIPFLPVYLLELGVEQEQLAIWsglsFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFL 106
Cdd:cd17477 205 GAFYSLLPLYGLRLGLSVAQAALL----LAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLAL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 107 LVRAF--QGFANGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIVTAAI 184
Cdd:cd17477 281 LVLLFlwGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
9-187 |
1.81e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.40 E-value: 1.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 9 MVAVWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQlaiwSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGIL 88
Cdd:cd17478 194 WRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVF----AGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 89 IGLSYLWSAFVQDEYQFLLVRAFQGFANGFMPAAMTMVSLSVPkERVGTAMGIFqMGL--VLGNTVGPLTGGLTElAVGM 166
Cdd:cd17478 270 AAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLP-GNVGLASGLM-MGLsfGLGGIGAPVLGALAD-AFGL 346
|
170 180
....*....|....*....|.
gi 1547460756 167 RPVFMVAGITLFIvtAAIAIF 187
Cdd:cd17478 347 ESVLLILALLPLL--GALLAF 365
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
14-391 |
1.96e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.11 E-value: 1.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 14 ILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLAIWSglsfSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSY 93
Cdd:cd17312 7 GVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIG----SAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALAN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 94 LWSAFVQDEYQFLLVRAFQGFAN--GFMPAAMTMVSLSVPKERvGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFM 171
Cdd:cd17312 83 IFMGFSTSLWFFAVLWGLNGLFQsmGWPPCVKLLGNWFSKKER-GTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 172 VAGITLFIVTAAIAIFVKEpqmesetpvkttsfsedlqaakQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEG 251
Cdd:cd17312 162 VPGIVGLVVAIILFFFLRD----------------------SPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLI 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 252 AAMLAGSILSGGGVMGMIMTNVWA--AYGQRRGYFRVIsYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLG 329
Cdd:cd17312 220 DAGWFSSLYEVGGIAGTILAGLLSdkLFGGRRAPIAVI-YMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIG 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1547460756 330 SAMTVNTDPS-VRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVL 391
Cdd:cd17312 299 GAAAQDIGRKeAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLL 361
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
12-191 |
1.98e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.41 E-value: 1.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 12 VWILTIGMSLLAICYTMIIPFLPVYLLE-LGVEQEQLAIWSglsfSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIG 90
Cdd:COG2223 207 FWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLA----ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 91 LSYLWSAFVQDEYQ-----FLLVRAFQGFANGFMPAamtMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVG 165
Cdd:COG2223 283 LGLLLLALALGSLWlflvlFLLLGLALGGGNGAVFA---LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG 359
|
170 180
....*....|....*....|....*.
gi 1547460756 166 MRPVFMVAGITLFIVTAAIAIFVKEP 191
Cdd:COG2223 360 SYTAAFLVFAVLALVALVLTLLLYRR 385
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-186 |
2.17e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 46.06 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 12 VWILTIGMSLLAICYTMIIPFLPVYLLELgveQEQLAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGL 91
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTV---LGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 92 SYLWSAFVQDE---YQFLLVRAFQGFANGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRP 168
Cdd:cd17316 256 LALPLFYLLSGsptLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335
|
170
....*....|....*...
gi 1547460756 169 VFMVAGITLFIVTAAIAI 186
Cdd:cd17316 336 VPALILALLAIVALIVAL 353
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
10-393 |
2.43e-05 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 46.11 E-value: 2.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 10 VAVWILTIGMSLLAicYTMIIPFLPVyLLELGVEQEQLAIWSGLSFSISFFIAAIMA----------------------- 66
Cdd:cd17389 1 ITIVFLALLLDLLA--FTIILPLFPS-LLDYYGQNDDSGLYSLQISSVDWFRDAIGApderrynsvlfggligslfsllq 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 67 ----PVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQGFANGFMPAAMTMVSLSVPKERVGTAMGIF 142
Cdd:cd17389 78 flssPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 143 QMGLVLGNTVGPLTGG------LTELAVGMRPVFMVAGITLFIVTAAIAIFVKEPQMESetpVKTTSFSEDLQaakqnkv 216
Cdd:cd17389 158 GVAFSLGFIIGPMIGAyfasftRSLGEVFFSMPALFALVLALADLLFIFFFLPETLPSN---LRRLGLVYFLY------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 217 LLHILGLYFLVqaVMLMLQPIVAiyvgelkGSMEGAAMLAgsilsgggVMGMIMTNVWAAYGQRR---GYFRVISYGLLG 293
Cdd:cd17389 228 LFLFSGLEFTL--TFLTHQRFQY-------TSMQQGKMFF--------FIGIIMALVQGGYVRRIkpgKEKKAVLQGLIL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 294 TGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVatYW--G 371
Cdd:cd17389 291 LIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTV--YWlaG 368
|
410 420
....*....|....*....|..
gi 1547460756 372 TSYVFLVAGIGMMIIGYLVLKI 393
Cdd:cd17389 369 SEACYTIGALLFLLPLLLLARL 390
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
11-179 |
4.88e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 45.23 E-value: 4.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 11 AVWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLAIWSglsFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIG 90
Cdd:cd17324 199 RLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL---LLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 91 LSYLWSAFVQDEYQFLLVRAFQGFANGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVF 170
Cdd:cd17324 276 ALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355
|
....*....
gi 1547460756 171 MVAGITLFI 179
Cdd:cd17324 356 WVGAALLLL 364
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
53-391 |
5.18e-05 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 45.10 E-value: 5.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 53 LSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLV-RAFQGFANGFMPAAMTMVSLSVP 131
Cdd:cd17314 42 TAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSFPLSYAcFVFIGAGTGILYGSAVLVTTQYF 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 132 KERVGTAMGIFQMGLVLGNTVG-PLTGGLTELAvGMRPVFMVAGITLFIVTAAIAIFV-KEPQMESETPVKTTSFSEDLQ 209
Cdd:cd17314 122 PDTKGLALGLPTTGYSLGLVLGsPLLRILWVFY-GLALVYTILGILAAIVLSVVSLLGfKEPPDNQARLHVQKKKTQTMG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 210 AAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISY 289
Cdd:cd17314 201 EIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 290 GLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGP-LFASIVAT 368
Cdd:cd17314 281 TILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPmLGAKFYDR 360
|
330 340
....*....|....*....|...
gi 1547460756 369 YWGTSYVFLVAGIGMMIIGYLVL 391
Cdd:cd17314 361 TPSYISAVYIYAVIVFLASAILL 383
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
29-394 |
5.69e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 44.88 E-value: 5.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 29 IIPFLPVYLLELGVEQEQLAIWSGlsfsISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDE---YQF 105
Cdd:cd17335 16 LLPFLSVYLKQLGLSPTQIGILIG----IRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQifwLLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 106 LLVRAFQGFANGFMPAAMTMVSLSVPKER-----------VGTAMGIFQMGLVLGNTVGPltggltelaVGMRPVFMVAG 174
Cdd:cd17335 92 LLVILGAFFSAPVVPLVDSITLQYLGEERerygkqrlwgsIGFGIAALLVGILIDRSSTY---------KNYTIAFYVFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 175 ItLFIVTAAIAIFVKEPQMESETPVKTtsfsEDLQAAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSmegaAM 254
Cdd:cd17335 163 V-LMLLALLLALKFPFRPKHPEPNENT----GGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGS----KT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 255 LAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTV 334
Cdd:cd17335 234 LIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASA 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1547460756 335 NTDPSVRGRVFGL-ATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVLKIH 394
Cdd:cd17335 314 AAPPGLRATAQGLlQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQ 374
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
12-188 |
6.77e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.55 E-value: 6.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 12 VWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGL 91
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQI----GLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 92 SYLWSAFVQDEY-QFLLVRAFQGFANGFMPAAMTMVSLSVPKERVGTAMGIF----QMGLVLGNTVGPL---TGGLTELA 163
Cdd:cd17341 77 PLLALALAVSSYwGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIagagNMGVAVSQLLAPLiagAIVFDGGF 156
|
170 180
....*....|....*....|....*
gi 1547460756 164 VGMRPVFMVAGItlFIVTAAIAIFV 188
Cdd:cd17341 157 VGWRNAFFVPGI--LLAIAAVLVLL 179
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-186 |
7.53e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.34 E-value: 7.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 11 AVWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLAiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILI- 89
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA---GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLm 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 90 GLSYLWSAFVQDEYQFLLVRAFQGFAN-GFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRP 168
Cdd:cd06174 281 ALGLALLLLAPSLLLLLLLLLLLGFGLgGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLT 360
|
170
....*....|....*...
gi 1547460756 169 VFMVAGITLFIVTAAIAI 186
Cdd:cd06174 361 GAFLVLAVLLLLAAILLL 378
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
23-198 |
1.09e-04 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 44.13 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 23 AICYTMIIPFLPVYLLELGVEQEQlaiwSGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIrAGILIG----LSYLWSAF 98
Cdd:cd17385 12 MICYSILAPFFPREAEKKGVSDTI----IGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFV-AGMFVSggctILFGFLDR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 99 VQDEYQFL----LVRAFQGFANG-FMPAAMTMVSLSVPkERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVA 173
Cdd:cd17385 87 VPDGTVFIalcfLVRIVEAVGFAaFITASFAIIAKEFP-NNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVL 165
|
170 180
....*....|....*....|....*
gi 1547460756 174 GITLfIVTAAIAIFVKEPQMESETP 198
Cdd:cd17385 166 GCLL-LLTVPLNMFILPRYDDDPSP 189
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
12-188 |
1.23e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 43.71 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 12 VWILTIGMSLLAICYTMIIPFLPVYLLE-LGVEQEQLAIWSglsfSISFFIAAIMAPVWGRLADQHGK---KLMAIRAGI 87
Cdd:cd17319 181 VWGLALGYFGINYALYGLLTWLPTYLKQaRGFSLKQVGLLA----AIPFLAGAIGMILGGRLSDRLLRgarRLVIIIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 88 LIGLSYLWSAFVQDEYQFLLVRAFQGFANGF-MPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGP-LTGGLTELAVG 165
Cdd:cd17319 257 LAAVGLLLAYLTTSPVVAVILLSLAGFGIGAaSPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPlLIGYLVDATGS 336
|
170 180
....*....|....*....|...
gi 1547460756 166 MRPVFMVAGITLFIvtAAIAIFV 188
Cdd:cd17319 337 YTAAFLFLAAVALL--AALLVLL 357
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-188 |
1.24e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.76 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 11 AVWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLAiwsGLSFSISFFIAAIMAPVWGRLAdQHGKKLMAIRAGILI- 89
Cdd:cd17329 201 AFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLL---GLLLALNALLIVLLQFPVARLV-ERFRLRKILMIGILLf 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 90 GLSYLWSAFVQDEYQFLLVRAFQGFANGFM-PAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRP 168
Cdd:cd17329 277 AIGFAVLAFANTLAVLILAMIVLTLGEMLVfPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGL 356
|
170 180
....*....|....*....|
gi 1547460756 169 VFMVAGITLFIVTAAIAIFV 188
Cdd:cd17329 357 PWLILAALGLIAAALLLGLQ 376
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
306-398 |
3.01e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 42.75 E-value: 3.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 306 GLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGP-LFASIVATYWGTSYVFLVAGIGMM 384
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIAI 161
|
90
....*....|....
gi 1547460756 385 IIGYLVLKIHGNRP 398
Cdd:TIGR00881 162 IVSLICFLLLRDSP 175
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
26-187 |
7.35e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.46 E-value: 7.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 26 YTMIIPFLPVYLLELGveQEQLAIWSGLSFSISffiAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQF 105
Cdd:cd06179 14 VTLPAAVLPFIVADLG--PSSNSTWISTAWSLA---QAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNML 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 106 LLVRAFQGFANGFMPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGG--LTELAVGMRPVFMVAGITLFIVTAA 183
Cdd:cd06179 89 IGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGalVEANAAGWRWIFYINAIFNALALIL 168
|
....
gi 1547460756 184 IAIF 187
Cdd:cd06179 169 LFFF 172
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
119-391 |
7.99e-04 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 41.66 E-value: 7.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 119 MPAAMTMVSLSVPKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIVTAAIAIFVKEPQMESETP 198
Cdd:pfam05977 121 DPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGPAFTFALNALSYFAVIAALWRWKRAAPASPLPR 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 199 VK-TTSFSEDLQAAKQNKVLLHIL---GLYFLVQAVMLMLQPIVAiyvgelKGSMEGAAMLAGSILSGGGVMGMIMTNVW 274
Cdd:pfam05977 201 ERiFGAVRAGLRFTAMSRELRSVLvraFAFGLSASAVWALLPLVA------RDLLDGDAIFYGILLGAVGVGAILGALSL 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 275 AAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQL 354
Cdd:pfam05977 275 PRLRERLGSDRLVLLASVVTALVLLSLALAPNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGRALAVYQTVFFG 354
|
250 260 270
....*....|....*....|....*....|....*..
gi 1547460756 355 GNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVL 391
Cdd:pfam05977 355 GMAAGSWLWGAVAEALSVTGALLGAAAALLAGAAAGL 391
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
28-190 |
1.16e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 40.67 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 28 MIIPFLPVYLLELGVEQEQLAIwsglsfSISFFIA--AIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQF 105
Cdd:PRK11102 9 MYLPALPVIAADFGVSAGSVQM------TLSAYILgfAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 106 LLVRAFQGFANgfmpAAMTMVSLSV-----PKERVGTAMGIFQMGLVLGNTVGPLTGGLTELAVGMRPVFMVAGITLFIV 180
Cdd:PRK11102 83 IYMRFLHGLAA----AAASVVINALmrdmfPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILA 158
|
170
....*....|
gi 1547460756 181 TAAIAIFVKE 190
Cdd:PRK11102 159 AALVFFFIPE 168
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
10-179 |
1.55e-03 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 40.25 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 10 VAVWILTIGMSLLAicytmiiPFLPVYLLE-LGVEQEQLaiwsGLSF---SISFFIAAimaPVWGRLADQHGKKLMAIRA 85
Cdd:cd17384 201 GAICFSNSGIAILE-------PCLPIWMMEtMCPPKWQL----GTAFlpdSIGYLIGT---NLFGPLAHKIGRWLCSLLG 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 86 GILIGLSYLWSAFVQDEYQFLLVRAFQGFANGFMPAAM-TMVSLSVPKERV---GTAMGIFQMGLVLGNTVGPLTGGLTE 161
Cdd:cd17384 267 MLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVDSSMmPLLAYLVDLRHSsvyGSVYAIADVAFCLAFALGPSLGGAIV 346
|
170
....*....|....*...
gi 1547460756 162 LAVGMRPVFMVAGITLFI 179
Cdd:cd17384 347 KSIGFPWLMRIIGIINIL 364
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
11-186 |
1.93e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.84 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 11 AVWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLAiwsgLSFSISFFIAAIMAPVWGRLADQ--HGKKLMAIRAGIL 88
Cdd:cd17352 184 TFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAA----FLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLI 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 89 IGLSYLWSAFVQDEYQFLLVRAFQGFANGFMPAAMTMVSLS-VPKERVGTAMGIFQMGLVLGNTVG-PLTGGLTELAVGM 166
Cdd:cd17352 260 LGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADlVGLEKLSNAYGLVLLFQGLAALVGpPIAGLLRDYTGDY 339
|
170 180
....*....|....*....|
gi 1547460756 167 RPVFMVAGITLFIVTAAIAI 186
Cdd:cd17352 340 DAAFYFCGACLLLSGVLLFL 359
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
21-141 |
3.39e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 39.21 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 21 LLAICYTMIIPFLPVYLL--ELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAF 98
Cdd:TIGR00886 11 FLSFLVWFAFSPLAVFLIkdDLGLSTAQL----GNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGL 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1547460756 99 VQDEY-QFLLVRAFQGFANGFMPAAMTMVSLSVPKERVGTAMGI 141
Cdd:TIGR00886 87 AVQSYsVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGL 130
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
52-386 |
3.94e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.23 E-value: 3.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 52 GLSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQGFANGFMPAAMTMVSLSVP 131
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 132 KERVGTAMGIFQMGLVLGNTVGPLTGG-LTELAVGMRPVFMVAGITLFIVTAAIAI-FVKEPQMESETPVKTTSFSEDLQ 209
Cdd:cd17333 114 EESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLIYLLLAILILLtLFPELPSARNPQQSVGAFSASAS 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 210 AAKQNKVLLHILGLYFLVQAVMLMLQPIVAIYVGELKGSMEGAAMLAGSILSGGGVMGMIMTnvwAAYGQRRGYFRVISY 289
Cdd:cd17333 194 RLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLG---GPISRRIKPHTLLVL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 290 GLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLgSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATY 369
Cdd:cd17333 271 SGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTI-LSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEA 349
|
330
....*....|....*..
gi 1547460756 370 WGTSYVFLVAGIGMMII 386
Cdd:cd17333 350 VGIQTAMLLITILYAII 366
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
23-326 |
5.06e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.74 E-value: 5.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 23 AICYTMIIPFLPVYLL-ELGVeqeqLAIWSGLSFSISFFIAAIMAPVWGRLADQHGKKL-----MAIRAGILIGLSY--L 94
Cdd:cd17332 12 NLIFQIVSTYLLFFYTdVLGL----SAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWgrfrpWLLWGAIPLALLFvlL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 95 WSAFVQDEYQFLLVRAFQGFANGF-----------MPAAMTmvslSVPKERVGTAmGIFQMGLVLGNT-----VGPLTGG 158
Cdd:cd17332 88 FTTPDGSGTGKLIYALITYILLDLlytlvnipytaLIPELT----DDPEERTSLT-SWRMFFATIGGLlvtvlPPPLVAY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 159 LTELAVGmRPVFMVAGITLFIVTAAIAIF---VKEPQMESETPVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLMLQ 235
Cdd:cd17332 163 FGGGNAS-RGYFLTALIIGIIGIILLLICffgTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 236 PIVAIYVGELKGSMEGAAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFrvISYGLLGTGTVLLLQSLPFGLWWFGALQL 315
Cdd:cd17332 242 TVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFF--IGLLLAILGLLLLFFLPPGNLVLILVLAV 319
|
330
....*....|.
gi 1547460756 316 LIGVFIVGIFP 326
Cdd:cd17332 320 LAGIGYGGANL 330
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
11-187 |
5.22e-03 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 38.74 E-value: 5.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 11 AVWILTIGMSLLAICYTMIIPFLPVYLLELGVEQEQLaiwsGLSFSISFFIAAIMAPVWGRLADQHGK-KLMAIRAGILI 89
Cdd:cd17385 202 SVLLLCLSIVSGSVSLGFLDPTLSPHLRQFKLSPGQV----GLMFLILAGSYAISAPLWGWLSDKKKIpKWLMVIGSIIT 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 90 GLSYLW---SAFVQDEYQ---FLLVRAFQGFANG--FMPAAMTMVSLSVPK------ERVGTAMGIFQMGLVLGNTVGPL 155
Cdd:cd17385 278 GVGFLLlgpAPLLPIKSElwmVIIGLVLLGLSLGaaLVPTFPELLNCAREYgfpdnlSTYGLVSGLFNAAFSLGAFIGPT 357
|
170 180 190
....*....|....*....|....*....|..
gi 1547460756 156 TGGLTELAVGMRPVFMVAGITLFIVTAAIAIF 187
Cdd:cd17385 358 LGGFLLERLGFEWAATIQAGLAFVVGILMSIY 389
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
225-394 |
6.44e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.34 E-value: 6.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 225 FLVQAVMLMLQPIVAIYVGELKGSmegaAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLP 304
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAHDLGGS----EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 305 FGLWWFGALQLLIGVFIVGIFPSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMM 384
Cdd:cd17489 82 TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLAL 161
|
170
....*....|
gi 1547460756 385 IIGYLVLKIH 394
Cdd:cd17489 162 LALLLVFLVK 171
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
14-390 |
8.11e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.05 E-value: 8.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 14 ILTIGMSLLAICYTMIipfLPVYLLELGVEQEQLAiWSGLSFSISFFIAAIMAPvwgRLADQHGKKLMAIRAGILIGLSY 93
Cdd:cd06180 6 ALAVAMGIGRFAYTPL---LPLMLAELGLSYAQAG-WIATANYAGYLVGALLAS---FLRRRGRARRLIRGGLLLTVLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 94 LWSAFVQDEYQFLLVRAFQGFANGFMPAAMTMVSLSV-PKERVGTAMGIFQMGLVLGNTVGPLT-GGLTELAVGMRPVFM 171
Cdd:cd06180 79 AAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHaTAAGRGHLIGLLFAGVGLGIALSGLLvPAGLGGGLSWRAGWL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 172 VAGITLFIVTAAIAIFVKEPqmesetPVKTTSFSEDLQAAKQNKVLLHILGLYFLVQAVMLmlqpIVAIYVGELKGSMEG 251
Cdd:cd06180 159 ALALLSAVLLLLSFLLLRRG------PSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYI----ITATFLPLIARETGA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 252 AAMLAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIfPSLGSA 331
Cdd:cd06180 229 GSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAI-TALVMA 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1547460756 332 MTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLV 390
Cdd:cd06180 308 LARELAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALL 366
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
13-385 |
8.55e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 37.92 E-value: 8.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 13 WILTIGMSLLAICYTMIIP----FLPVYLLELGVEQEQLAIWSGLSFSISFFiaaiMAPVWGRLADQHGKKLMAIRAGIL 88
Cdd:cd17352 2 WVVVFASFLVNFFTDGILNsfgvLFVELLEEFGESTSDIAWIGSLLLGVSLF----SGPLSSALVNRFGCRPVAIAGGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 89 IGLSYLWSAFVQDEYQFLLVRAF-QGFANGFM-PAAMTMVSLSVPKERvGTAMGIFQMGLVLGNTVGPLTGGLTELAVGM 166
Cdd:cd17352 78 AALGLLLSSFATSLWQLYLTYGVlGGLGLGLIySPAIVIVGQYFEKKR-GLATGIAVAGSGVGTFVFPPLLRYLLDNYGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 167 RPVFM-VAGITLFIVTAAIAifvkepqmesetpvkttsfsedLQAAKQNKVLLHILGLYFLvqAVMLMLQPIVAIYVGEL 245
Cdd:cd17352 157 RGALLiLGGLCLNLCVCGLL----------------------LRLLKDPTFVLLALGVSFA--MLGFFVPFVYLPSYAKS 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 246 KGSMEGAAMLAGSILSGGGVMGMIMTNvWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIF 325
Cdd:cd17352 213 LGIDESDAAFLLSIIGISDIVGRILLG-LLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYS 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1547460756 326 PSLGSAMTVNTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGT-SYVFLVAGIGMMI 385
Cdd:cd17352 292 SLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDyDAAFYFCGACLLL 352
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
255-397 |
9.29e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 37.87 E-value: 9.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 255 LAGSILSGGGVMGMIMTNVWAAYGQRRGYFRVISYGLLGTGTVLLLQSLPFGLWWFGALQLLIGVFIVGIFPSLGSAMTV 334
Cdd:COG0477 50 QLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAE 129
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1547460756 335 NTDPSVRGRVFGLATTSQQLGNMIGPLFASIVATYWGTSYVFLVAGIGMMIIGYLVLKIHGNR 397
Cdd:COG0477 130 LFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESR 192
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
33-118 |
9.60e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 38.08 E-value: 9.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1547460756 33 LPVYLLELGVEQEQLAIwsglSFSISFFIAAIMAPVWGRLADQHGKKLMAIRAGILIGLSYLWSAFVQDEYQFLLVRAFQ 112
Cdd:PRK10473 26 LPRIAADLNASEAQLHI----AFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQ 101
|
....*.
gi 1547460756 113 GFANGF 118
Cdd:PRK10473 102 GIGAGC 107
|
|
| |
