NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1553136808|ref|WP_127593748|]
View 

nitroreductase [Paenibacillus lautus]

Protein Classification

nitroreductase( domain architecture ID 10114819)

nitroreductase catalyzes the reduction of flavin or nitrocompounds using NAD(P)H as electron donor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 5-168 3.39e-59

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


:

Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 182.42  E-value: 3.39e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   5 EAIRTRRSLGKVKPD-AVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQGEGRDVLGNALGDIQAAGGDDTSEEAVNAARE 83
Cdd:cd02135     2 ELIKTRRSIRKFKLTgAPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGEGRERLAELLAAAAAARAPGADPEKLEKARE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  84 sgrtKAYRAPVVIGVAVEPSTDPKVIELEEYGAVFAGIQNMLLQIHELGLGAVWRTGEPCFHTLMNQAFGLKPEDKMLGF 163
Cdd:cd02135    82 ----KALRAPVVIAVVAKPDEDPKVPEWEQYAAVGAAVQNLLLAAHALGLGAVWRTGPVTYDPAVREALGLPEDERIVGF 157


                  ....*
gi 1553136808 164 LYIGY 168
Cdd:cd02135   158 LYLGT 162
 
Name Accession Description Interval E-value
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 5-168 3.39e-59

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 182.42  E-value: 3.39e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   5 EAIRTRRSLGKVKPD-AVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQGEGRDVLGNALGDIQAAGGDDTSEEAVNAARE 83
Cdd:cd02135     2 ELIKTRRSIRKFKLTgAPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGEGRERLAELLAAAAAARAPGADPEKLEKARE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  84 sgrtKAYRAPVVIGVAVEPSTDPKVIELEEYGAVFAGIQNMLLQIHELGLGAVWRTGEPCFHTLMNQAFGLKPEDKMLGF 163
Cdd:cd02135    82 ----KALRAPVVIAVVAKPDEDPKVPEWEQYAAVGAAVQNLLLAAHALGLGAVWRTGPVTYDPAVREALGLPEDERIVGF 157


                  ....*
gi 1553136808 164 LYIGY 168
Cdd:cd02135   158 LYLGT 162
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 3-185 1.30e-37

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 127.66  E-value: 1.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   3 VSEAIRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQGEG-RDVLGNALgdiqaaggddtseeavnaa 81
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPElRERLAEAL------------------- 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  82 RESGRTKAYRAPVVIGVAVEPSTDPKVIELEEYGAVFAGIQNMLLQIHELGLGAVWRTGepCFHTLMNQAFGLKPEDKML 161
Cdd:COG0778    62 AEANQEWVADAPVLIVVCADPDRSEKVPERYALLDAGIAAQNLLLAARALGLGTCWIGG--FDPEKVRELLGLPEGEEPV 139

                         170       180
                  ....*....|....*....|....
gi 1553136808 162 GFLYIGYPDMEPKQGKRQPAANKT 185
Cdd:COG0778   140 ALLALGYPAEELNPRPRKPLEEVV 163
PRK10828 PRK10828
putative oxidoreductase; Provisional
 1-169 9.80e-29

putative oxidoreductase; Provisional


Pssm-ID: 182761  Cd Length: 183  Bit Score: 105.54  E-value: 9.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   1 MNVSEAIRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQGEGRDVLGNALgdIQAAGGDDTSEEAVNA 80
Cdd:PRK10828    1 MDALELLLNRRSASRLAEPAPTGEQLQNILRAGMRAPDHGSLQPWRFFVIEGEGRERFSALL--EQGAIAAGSDEKAIEK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  81 ARESgrtkAYRAPVVIGVAVEPSTDPKVIELEEygAVFAGIQNMLLQIHEL--GLGAVWRTGEPCFHTLMNQAFGLKPED 158
Cdd:PRK10828   79 ARNA----PFRAPLIITVVAKCEENHKVPRWEQ--EVSAGCAVMAMQMAAVaqGFNGIWRSGAWTESPVVREAFGCREQD 152

                         170
                  ....*....|.
gi 1553136808 159 KMLGFLYIGYP 169
Cdd:PRK10828  153 KIVGFLYLGTP 163
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 7-168 4.70e-26

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 98.23  E-value: 4.70e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   7 IRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFV-MQGEGRDVLGNALGDIQA---AGGDDTSEEAVNAAR 82
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVvTDGELRYRLAEAALELLLvepAAALLLLLRRDANLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  83 ESGRTKAYRAPVVIGVAVEPSTD----PKVIELEEYGAVFAGIQNMLLQIHELGLGAVWRTGepcFHT-LMNQAFGLKPE 157
Cdd:pfam00881  81 LLLQDFLRGAPVLIVITASLSTYlrkaAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGG---FDAaAVRELLGLPDD 157

                         170
                  ....*....|.
gi 1553136808 158 DKMLGFLYIGY 168
Cdd:pfam00881 158 ERLVGLIAVGY 168
 
Name Accession Description Interval E-value
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 5-168 3.39e-59

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 182.42  E-value: 3.39e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   5 EAIRTRRSLGKVKPD-AVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQGEGRDVLGNALGDIQAAGGDDTSEEAVNAARE 83
Cdd:cd02135     2 ELIKTRRSIRKFKLTgAPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGEGRERLAELLAAAAAARAPGADPEKLEKARE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  84 sgrtKAYRAPVVIGVAVEPSTDPKVIELEEYGAVFAGIQNMLLQIHELGLGAVWRTGEPCFHTLMNQAFGLKPEDKMLGF 163
Cdd:cd02135    82 ----KALRAPVVIAVVAKPDEDPKVPEWEQYAAVGAAVQNLLLAAHALGLGAVWRTGPVTYDPAVREALGLPEDERIVGF 157


                  ....*
gi 1553136808 164 LYIGY 168
Cdd:cd02135   158 LYLGT 162
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 3-185 1.30e-37

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 127.66  E-value: 1.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   3 VSEAIRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQGEG-RDVLGNALgdiqaaggddtseeavnaa 81
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPElRERLAEAL------------------- 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  82 RESGRTKAYRAPVVIGVAVEPSTDPKVIELEEYGAVFAGIQNMLLQIHELGLGAVWRTGepCFHTLMNQAFGLKPEDKML 161
Cdd:COG0778    62 AEANQEWVADAPVLIVVCADPDRSEKVPERYALLDAGIAAQNLLLAARALGLGTCWIGG--FDPEKVRELLGLPEGEEPV 139

                         170       180
                  ....*....|....*....|....
gi 1553136808 162 GFLYIGYPDMEPKQGKRQPAANKT 185
Cdd:COG0778   140 ALLALGYPAEELNPRPRKPLEEVV 163
PRK10828 PRK10828
putative oxidoreductase; Provisional
 1-169 9.80e-29

putative oxidoreductase; Provisional


Pssm-ID: 182761  Cd Length: 183  Bit Score: 105.54  E-value: 9.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   1 MNVSEAIRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQGEGRDVLGNALgdIQAAGGDDTSEEAVNA 80
Cdd:PRK10828    1 MDALELLLNRRSASRLAEPAPTGEQLQNILRAGMRAPDHGSLQPWRFFVIEGEGRERFSALL--EQGAIAAGSDEKAIEK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  81 ARESgrtkAYRAPVVIGVAVEPSTDPKVIELEEygAVFAGIQNMLLQIHEL--GLGAVWRTGEPCFHTLMNQAFGLKPED 158
Cdd:PRK10828   79 ARNA----PFRAPLIITVVAKCEENHKVPRWEQ--EVSAGCAVMAMQMAAVaqGFNGIWRSGAWTESPVVREAFGCREQD 152

                         170
                  ....*....|.
gi 1553136808 159 KMLGFLYIGYP 169
Cdd:PRK10828  153 KIVGFLYLGTP 163
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 7-168 4.70e-26

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 98.23  E-value: 4.70e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   7 IRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFV-MQGEGRDVLGNALGDIQA---AGGDDTSEEAVNAAR 82
Cdd:pfam00881   1 IRQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVvTDGELRYRLAEAALELLLvepAAALLLLLRRDANLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  83 ESGRTKAYRAPVVIGVAVEPSTD----PKVIELEEYGAVFAGIQNMLLQIHELGLGAVWRTGepcFHT-LMNQAFGLKPE 157
Cdd:pfam00881  81 LLLQDFLRGAPVLIVITASLSTYlrkaAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGG---FDAaAVRELLGLPDD 157

                         170
                  ....*....|.
gi 1553136808 158 DKMLGFLYIGY 168
Cdd:pfam00881 158 ERLVGLIAVGY 168
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 6-172 2.17e-24

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 93.42  E-value: 2.17e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   6 AIRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQGEGRDVLgnalgdiqaaggddtseeavnaaresg 85
Cdd:cd02136     1 AIKSRRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTGKARERL--------------------------- 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  86 RTKAYRAPVVIGVAVEPSTDPKVIelEEYGAVfagIQNMLLQIHELGLGAVWRTGEPCFHTLMNQAFGLKPEDKMLGFLY 165
Cdd:cd02136    54 KKAFFGAPVALFLTMDKVLGPWSW--FDLGAF---LQNLMLAAHALGLGTCPQGALAGYPDVVRKELGIPDDEELVCGIA 128


                  ....*..
gi 1553136808 166 IGYPDME 172
Cdd:cd02136   129 LGYPDPD 135
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 7-140 1.25e-23

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 91.57  E-value: 1.25e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   7 IRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQGEGRD-VLGNALG---DIQAAGGDDTSEEAVNAAR 82
Cdd:cd20610     1 IKKRRSIRKFKPDPVPKEDIEKILEAANWAPSGMNRQNWEFVVVKGGEKIeKIGISIKkknEEIARLLEKVFAEKPIRFR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1553136808  83 ESGRTKAY--RAPVVIGVAVEPSTDPKVIE--LEEYGAVfagIQNMLLQIHELGLGAVWRTG 140
Cdd:cd20610    81 KFRRFFTLfgGAPVLVVVYTEPYKPPEERKpdLQSVSAA---IQNLLLAAHALGLGTCWMTG 139
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 7-168 6.20e-21

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 83.89  E-value: 6.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   7 IRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQGEGRDvlgnalgdiqaaggddtseEAVNAARESGR 86
Cdd:cd02062     1 IKTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKK-------------------EKLAKLAAPNQ 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  87 TKAYRAPVVIGVAVEPSTDPKVIELeeygAVFAGIQNMLLQIHELGLGAVWRTGEPCFHTLMNQAFGLKPEDKMLGFLYI 166
Cdd:cd02062    62 KFIAGAPVVIVVVADPDKSRPWALE----DAGAAAQNLLLAAAALGLGSCWIGGFDFREDKVRELLGIPENLRPVALIAI 137


                  ..
gi 1553136808 167 GY 168
Cdd:cd02062   138 GY 139
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 5-137 4.36e-17

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 73.91  E-value: 4.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   5 EAIRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMqgEGRDVLgnalgdiqaaggddtSEEAVNAARES 84
Cdd:cd20608     2 EAIKTRRSVRRFSDKPVEEEKLEKILEAARLAPSWANKQCWRFIVV--TDKETL---------------SELAKKESPSN 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1553136808  85 GRTKAyrAPVVIGVAVEPStDPKVIELEEYGAVFAGI--QNMLLQIHELGLGAVW 137
Cdd:cd20608    65 GWLKD--APVIIVVCADPK-DSGWLNGQNYYLVDAAIamQNLMLAATDLGLGTCW 116
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 3-180 5.52e-17

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 74.43  E-value: 5.52e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   3 VSEAIRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQGEgrdvlgnalgdiqaaggdDTSEEAVNAAR 82
Cdd:cd02139     1 VYEAIKKRRSIRKYKPTPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDK------------------ELKEKLAEAAN 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  83 esGRTKAYRAPVVIgVAVEPSTDPKVIELEEYGAVFAGI--QNMLLQIHELGLGAVWrTGepcfhtlmnqAFG------- 153
Cdd:cd02139    63 --GQKFIAEAPVVI-VACADPSESGMGCGKPYYLVDVAIamEHLVLAATEEGLGTCW-IG----------AFDedkvkei 128

                         170       180
                  ....*....|....*....|....*....
gi 1553136808 154 LK-PED-KMLGFLYIGYPDMEPKQGKRQP 180
Cdd:cd02139   129 LGiPEEyRVVALTPLGYPAEEPPPRPRKP 157
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 2-168 1.58e-16

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 72.42  E-value: 1.58e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   2 NVSEAIRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQgegrdvlgnalgdiqaaggddtSEEAVNAA 81
Cdd:cd20609     1 DFLELAKKRYSVRKFSDKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVR----------------------SEEALEKL 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  82 RESGRTkAYRAPVVIGVAVEPST------DPKvieleEYGAVFAGI--QNMLLQIHELGLGAVWRTGepcFHT-LMNQAF 152
Cdd:cd20609    59 AKATPR-FFGAPLVIVVCYDKDEswkrpyDGK-----DSGDIDAAIvaTHMMLAATELGLGTCWVGN---FDPeKVREAF 129

                         170
                  ....*....|....*.
gi 1553136808 153 GLKPEDKMLGFLYIGY 168
Cdd:cd20609   130 NLPENLEPVAILPLGY 145
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 7-175 5.31e-14

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 66.09  E-value: 5.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   7 IRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQgeGRDVLgNALGDIQAAGGddtseeavnaaresgr 86
Cdd:cd02150     1 ILTRRSIRKYTDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVT--DREKL-DKIAEAHPYGK---------------- 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  87 tKAYRAPVVIGVAvepsTDPKVIELEEYGAV--FAGIQNMLLQIHELGLGAVWRTGEPcFHTLMN---QAFGLKPEDKML 161
Cdd:cd02150    62 -MLKEAPLAIVVC----GDPSKEKAPGYWVQdcSAATENILLAAHALGLGAVWLGVYP-FEERVKairEILNIPENIIPF 135

                         170
                  ....*....|....
gi 1553136808 162 GFLYIGYPDMEPKQ 175
Cdd:cd02150   136 CVIALGYPAEEKEP 149
BluB cd02145
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5, ...
 5-175 5.49e-13

5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.


Pssm-ID: 380321  Cd Length: 196  Bit Score: 64.30  E-value: 5.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   5 EAIRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMqgEGRDVLGNALGDIQAAggddtSEEAVNAArES 84
Cdd:cd02145     2 RVIRWRRDVRHFRPDPVPEEVLERLLQAAHLAPSVGLMQPWRFVRV--RSAATRKAVHELFQRA-----NAEAAEMY-TG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  85 GRTKAYR---------APVVIGVAVEPSTDPKVI-------ELEEYGAVFAgIQNMLLQIHELGLGAVWRTgepCFH-TL 147
Cdd:cd02145    74 ERAAQYRtlklegieeAPLQLAVFCDRARAGGHGlgrttmpEMDLYSSVCA-VQNLWLAARAEGLGVGWVS---ILDpDE 149

                         170       180
                  ....*....|....*....|....*...
gi 1553136808 148 MNQAFGLKPEDKMLGFLYIGYPDMEPKQ 175
Cdd:cd02145   150 VKRLLGIPEHWEPVAYLCIGYPEFFYDE 177
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 5-174 2.48e-12

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 61.78  E-value: 2.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   5 EAIRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMqgEGRDVLgnalgdiqaaggddtseEAVNAARES 84
Cdd:cd02151     1 ELLKKRRSIRKYTDEPIEEEKLEEILEAALLAPSSRNSRPVEFIVV--DDKETL-----------------KKLSECKPH 61

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  85 GRTKAYRAPVVIGVAVEPSTDPKVIEleeyGAVFAGIqNMLLQIHELGLGAVW-----------RTGEPCFHTLmnqaFG 153
Cdd:cd02151    62 GSAFLKGAPAAIVVLADTEKSDTWIE----DASIAAT-YIQLAAESLGLGSCWiqirnretqdgKTAEEYVREL----LG 132

                         170       180
                  ....*....|....*....|.
gi 1553136808 154 LKPEDKMLGFLYIGYPDMEPK 174
Cdd:cd02151   133 IPENYRVLCIIALGYPDEEKP 153
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 6-135 4.10e-09

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 53.32  E-value: 4.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   6 AIRTRRSLGKVKPDAVPQEWIEQIIEAGTWAP---NHkltEPWKFFVmqgegrdvlgnalgdiqAAGGDDTSEEAVNAAR 82
Cdd:cd02138     1 LIAERWSPRAFSPEPISEEDLLSLFEAARWAPscfNE---QPWRFVV-----------------ARRDTEAFEKLLDLLA 60

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1553136808  83 ESGRTKAYRAPVVIGVAVEPSTDPKVIELEeyGAVF---AGIQNMLLQIHELGLGA 135
Cdd:cd02138    61 EGNQSWAKNAPVLIVVLAKTEFDHNGKPNR--YALFdtgAAVANLALQATALGLVV 114
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 3-51 8.89e-08

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 50.01  E-value: 8.89e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1553136808   3 VSEAIRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQ 51
Cdd:cd03370     1 VKEAIESRRSIRKYTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVR 49
PRK13294 PRK13294
F420-0--gamma-glutamyl ligase; Provisional
 5-174 7.78e-06

F420-0--gamma-glutamyl ligase; Provisional


Pssm-ID: 183957 [Multi-domain]  Cd Length: 448  Bit Score: 45.39  E-value: 7.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   5 EAIRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMQ-GEGRDVLGNALGDIQAAG--GDDTSEEAVnaA 81
Cdd:PRK13294  255 EAVLLRRSVREFSDDPVDPEAVRRAVAAALTAPAPHHTRPVRFVWLRsAAVRTRLLDAMRDAWRADlrADGLSEESI--A 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  82 RESGRTKA-YRAPVVI-------GVAVEPSTDPKVIELEEYG-AVFAGIQNMLLQIHELGLGAVWrTGEPCF-HTLMNQA 151
Cdd:PRK13294  333 RRVRRGDIlYDAPELVvpflvpdGAHSYPDARRTAAERTMFTvAVGAAVQNLLVALAVEGLGSCW-IGSTIFaADVVRAV 411

                         170       180
                  ....*....|....*....|....
gi 1553136808 152 FGLkPED-KMLGFLYIGYPDMEPK 174
Cdd:PRK13294  412 LDL-PADwEPLGAVAIGHPAEPPG 434
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 7-169 8.21e-06

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 44.39  E-value: 8.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   7 IRTRRSLGKVKPDAVPQEWIEQIIEAGTWAPNHKLTEPWKFFVMqgEGRDVLGN----------ALGDIQAAGGDDTSEE 76
Cdd:cd02143     2 LRSRRSIRRYKDKPVPRETLEKLLDIARYAPTGHNSQPVHWLVV--DDPEKVRRlaelvidwmrELIKEDPELAGKLFLD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  77 AVNAARESGRTKAYR-APVVIgVAVEPSTDPkvieleeYGAVFAGI--QNMLLQIHELGLGAVWrTG---------EPcf 144
Cdd:cd02143    80 GIVAAWEKGIDVILRgAPHLV-VAHAPKDAP-------TPPVDCAIalTYLELAAPSLGLGTCW-AGfftaaannyPP-- 148

                         170       180
                  ....*....|....*....|....*.
gi 1553136808 145 htlMNQAFGLkPEDKML-GFLYIGYP 169
Cdd:cd02143   149 ---LREALGL-PEGHKVgGAMMLGYP 170
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 4-180 1.02e-04

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 40.69  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808   4 SEAIRTRRSLGKVKPDA-VPQEWIEQIIEAGTWAPNHKLTEPWKFFVMqgegrdvlgnalgdiqaaggddTSEEAVNAAR 82
Cdd:cd02137     1 LEVIKSRRSVRNFDPDHkIPKEELKEILELATLAPSSFNLQPWRFVVV----------------------RDPELKAKLA 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  83 ES--GRTKAYRAPVVIGVAVEPStdpkvieleeyGAVFAgiQNMLLQIHELGLGAVWRTGepcF-HTLMNQAFGLKPEDK 159
Cdd:cd02137    59 EAayNQPQVTTASAVILVLGDLN-----------AGLAA--MNLMLAAKAKGYDTCPMGG---FdKEKVAELLNLPDRYV 122

                         170       180
                  ....*....|....*....|.
gi 1553136808 160 MLGFLYIGYPDMEPKQGKRQP 180
Cdd:cd02137   123 PVLLIAIGKAADKAPRSGRLP 143
FbiB_C-like cd20607
nitroreductase family domain similar to the C-terminal domain of F420:gamma-glutamyl ligase ...
 37-181 6.11e-03

nitroreductase family domain similar to the C-terminal domain of F420:gamma-glutamyl ligase FbiB; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Mycobacterium tuberculosis FbiB, is a two-domain protein and produces F420 with predominantly 5 to 7 L-glutamate residues in the poly-gamma-glutamate tail, its C-terminal domain is homologous to FMN-dependent nitroreductases.


Pssm-ID: 380328 [Multi-domain]  Cd Length: 155  Bit Score: 35.91  E-value: 6.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553136808  37 PNHklTEPWKFFVMQGEG-RDVLGNALGD--IQAAGGDDTSEEAVNAARESGRTkAYRAP-VVIGVAVEPST----DPKV 108
Cdd:cd20607     1 PHH--TRPWRFVWLQDPAiRKELLDRMADrwEADLTGDGLTPEAIARRVSRGQI-LYDAPeVVIPFLVPDGAhtypDARR 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1553136808 109 IELEEYG---AVFAGIQNMLLQIHELGLGAVWrTGEPCFHT-LMNQAFGLKPEDKMLGFLYIGYPDMEPkqGKRQPA 181
Cdd:cd20607    78 TDAEHTMftvAVGAAVQALLVALAVRGLGSCW-IGSTIFAPdVVRDELDLPDDWEPLGAIAIGYPLEPP--PPRPPA 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH