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Conserved domains on  [gi|1553139769|ref|WP_127596709|]
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amino acid ABC transporter permease [Sinorhizobium meliloti]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 3-220 8.36e-64

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 197.99  E-value: 8.36e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769   3 YSMDFAPVIARIPDLVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLPY 82
Cdd:COG0765     1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  83 AGVKLNADQAAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGT 162
Cdd:COG0765    81 LGIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1553139769 163 SIVSAISAKELTMAGATIESQSFRSLETFLVVAAIYICITFAFRFVYWLIGLWLFRRR 220
Cdd:COG0765   161 SLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 3-220 8.36e-64

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 197.99  E-value: 8.36e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769   3 YSMDFAPVIARIPDLVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLPY 82
Cdd:COG0765     1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  83 AGVKLNADQAAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGT 162
Cdd:COG0765    81 LGIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1553139769 163 SIVSAISAKELTMAGATIESQSFRSLETFLVVAAIYICITFAFRFVYWLIGLWLFRRR 220
Cdd:COG0765   161 SLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 6-208 3.85e-34

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 122.09  E-value: 3.85e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769   6 DFAPVIARIPDLVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLPYA-- 83
Cdd:PRK09494    4 DWSAIWPAIPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAfn 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  84 GVKLNADQAAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGTS 163
Cdd:PRK09494   84 DLRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTS 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1553139769 164 IVSAISAKELTMAGATIESQSFRSLETFLVVAAIYICITFAFRFV 208
Cdd:PRK09494  164 LFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFI 208
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 12-219 8.06e-25

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 97.61  E-value: 8.06e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  12 ARIPDLVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLPYAGVKLNADQ 91
Cdd:TIGR03004   2 AYLPLLLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPLIGLSLDPVT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  92 AAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGTSIVSAISAK 171
Cdd:TIGR03004  82 TGVMVLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLA 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1553139769 172 ELTMAGATIESQSFRSLETFLVVAAIYicitFAFRFVYWLIGLWLFRR 219
Cdd:TIGR03004 162 DLTFAAQSIRNLTLDTLSIFAITLLCY----FVMALIIMLIMRVLERV 205
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 21-205 1.86e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 55.36  E-value: 1.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  21 AINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLPYAGVKLNADQ---AAIFAV 97
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGlglPALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  98 SLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGTSIVSAISAKELTMAG 177
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                         170       180
                  ....*....|....*....|....*...
gi 1553139769 178 ATIESQSFRSLETFLVVAAIYICITFAF 205
Cdd:cd06261   161 TGLLLIFAILFPGDLGVAAAVALILLLL 188
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 35-209 9.06e-04

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 38.82  E-value: 9.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  35 GLTIGLCVALARFSgpvWCRFISACYVEGFRNTPLLVQLFLIYFGLPYAGVKLNAdQAAIFAVSLNLGAYSTEIFRAGLM 114
Cdd:pfam00528   1 GIPLGIIAALRRGR---RLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGI-LPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769 115 AIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGTSIVSAISAKE---LTMAGATIESQSFRSLETF 191
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPglgLLLIEAILGYDYPEIQGPV 156

                         170
                  ....*....|....*...
gi 1553139769 192 LVVAAIYICITFAFRFVY 209
Cdd:pfam00528 157 LAAALILLLLNLLVDILQ 174
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 3-220 8.36e-64

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 197.99  E-value: 8.36e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769   3 YSMDFAPVIARIPDLVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLPY 82
Cdd:COG0765     1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  83 AGVKLNADQAAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGT 162
Cdd:COG0765    81 LGIDLSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1553139769 163 SIVSAISAKELTMAGATIESQSFRSLETFLVVAAIYICITFAFRFVYWLIGLWLFRRR 220
Cdd:COG0765   161 SLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 5-222 1.33e-45

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 151.79  E-value: 1.33e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769   5 MDFAPVIARIPDLVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLP-YA 83
Cdd:COG4160     1 MDLDLLFEYLPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGqFE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  84 GVKL--------NADQAAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQL 155
Cdd:COG4160    81 WVREswlwpllrDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEV 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1553139769 156 TLTLLGTSIVSAISAKELTMAGATIESQSFRSLETFLVVAAIYICITFAFRFVYWLIGLWLFRRRAP 222
Cdd:COG4160   161 ILMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRLLRHLRP 227
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 6-208 3.85e-34

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 122.09  E-value: 3.85e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769   6 DFAPVIARIPDLVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLPYA-- 83
Cdd:PRK09494    4 DWSAIWPAIPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAfn 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  84 GVKLNADQAAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGTS 163
Cdd:PRK09494   84 DLRIDPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTS 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1553139769 164 IVSAISAKELTMAGATIESQSFRSLETFLVVAAIYICITFAFRFV 208
Cdd:PRK09494  164 LFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFI 208
PRK15100 PRK15100
cystine ABC transporter permease;
10-198 9.52e-32

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 115.62  E-value: 9.52e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  10 VIARIPDLVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLPYAGVKLNA 89
Cdd:PRK15100    8 VIDSAPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  90 DQAAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGTSIVSAIS 169
Cdd:PRK15100   88 IPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQ 167

                         170       180
                  ....*....|....*....|....*....
gi 1553139769 170 AKELTMAGATIESQSFRSLETFLVVAAIY 198
Cdd:PRK15100  168 VPELFRQAQLITSRTLEVFTMYLAASLIY 196
ArtQ COG4215
ABC-type arginine transport system, permease component [Amino acid transport and metabolism];
15-230 5.00e-28

ABC-type arginine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443361 [Multi-domain]  Cd Length: 238  Bit Score: 106.36  E-value: 5.00e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  15 PDLVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLPYA----------- 83
Cdd:COG4215    16 PALLAGALVTLELALLSLLLGLVLGLLGALAKLSGNRPLRWLATGYTTVVRGVPDLLLILLLYFGGQILlnaladlfgyd 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  84 -GVKLNADQAAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGT 162
Cdd:COG4215    96 gFIEINPFVAGVLALGFVFGAYATEVFRGAFLAVPKGQIEAARAYGMSRWQVFRRILLPQMWRYALPGLGNNWLVLLKDT 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1553139769 163 SIVSAISAKELTM-----AGATIESQSFrsletFLVVAAIYICITFAFrfvywLIGLWLFRRRAPTGSATAGL 230
Cdd:COG4215   176 ALVSVIGLVDLVRqaqeaAGSTREPFTF-----YLAAALIYLALTTVS-----ELVLARLERRASRGVRRAAG 238
ectoine_ehuC TIGR03004
ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are ...
 12-219 8.06e-25

ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons. Permease subunits EhuC and EhuD are homologous.


Pssm-ID: 132049 [Multi-domain]  Cd Length: 214  Bit Score: 97.61  E-value: 8.06e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  12 ARIPDLVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLPYAGVKLNADQ 91
Cdd:TIGR03004   2 AYLPLLLQGAWVTMQITLAGSVLATVLAFFAGLGRVSGGPILRTVALCYIEVFRGTSLLVQLFWFYFVLPLIGLSLDPVT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  92 AAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGTSIVSAISAK 171
Cdd:TIGR03004  82 TGVMVLGLHAGAYGAEIVRGALSSVSVQQLEACRALNFTRFQTLRRISLPQALVEMMPAFGNLAIELLKLTSLVSLISLA 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1553139769 172 ELTMAGATIESQSFRSLETFLVVAAIYicitFAFRFVYWLIGLWLFRR 219
Cdd:TIGR03004 162 DLTFAAQSIRNLTLDTLSIFAITLLCY----FVMALIIMLIMRVLERV 205
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 14-111 2.89e-23

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 89.90  E-value: 2.89e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  14 IPDLVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLPYAGVKLNADQAA 93
Cdd:TIGR01726   2 LPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTAA 81

                          90
                  ....*....|....*...
gi 1553139769  94 IFAVSLNLGAYSTEIFRA 111
Cdd:TIGR01726  82 VIALTLFYGAYLAEIFRG 99
PRK15069 PRK15069
histidine ABC transporter permease HisM;
18-219 2.16e-19

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 83.56  E-value: 2.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  18 VSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGL-PYAGVK----LNA--- 89
Cdd:PRK15069   20 FTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYTGMySLEIVRgtdlLDAffr 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  90 --DQAAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGTSIVSA 167
Cdd:PRK15069  100 sgLNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFT 179

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1553139769 168 ISAKELTMAGATIESQSFRSLETFLVVAAIYICITFAFrfvywligLWLFRR 219
Cdd:PRK15069  180 ATVPDILKIARDINSATYQPFQAFGIAAVLYLIISFVL--------ISLFRR 223
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
3-204 2.36e-16

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 75.25  E-value: 2.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769   3 YSMDFAPVIARIPDLVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLP- 81
Cdd:PRK15107    2 YEFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPg 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  82 ----YAGVKLNAD---QAAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQ 154
Cdd:PRK15107   82 flqnVLGLSPKTDirlISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQ 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1553139769 155 LTLTLLGTSIVSAISAKELTMAGATIESQSFRSLETFLVVAAIYICITFA 204
Cdd:PRK15107  162 GIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLS 211
artM PRK11122
arginine ABC transporter permease ArtM;
14-202 4.22e-16

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 74.22  E-value: 4.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  14 IPDLVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFG---------LPYAG 84
Cdd:PRK11122    5 LPELLKGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGpgqfpwlqeYPWLW 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  85 VKL-NADQAAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRyvVLIP-ALRIIYPALTGQLTLTLLGT 162
Cdd:PRK11122   85 HLLsQPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR--ILLPyAFKRALSSYSNEVVLVFKST 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1553139769 163 SIVSAISAKELTMAGATIESQSFRSLeTFLVVAAIYICIT 202
Cdd:PRK11122  163 SLAYTITLMDVMGYSQLLYGRTYDVM-VFGAAGIIYLVVN 201
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 20-201 2.23e-11

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 62.47  E-value: 2.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  20 GAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYF--------------------- 78
Cdd:COG4597    91 GLLNTLLVAVLGIVLATILGFLVGIARLSSNWLVSKLATVYVEIFRNIPLLLQIFFWYFavlealpsprqslslfdgvfl 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  79 -----------------------------------------------------------GLP-----YAGVKLNADQ--- 91
Cdd:COG4597   171 nnrglylpapvfepgfgwvlaallaaivaafvlrrwarrrqeatgqrfpvwwislallvGLPllaflLLGAPLSLDYpel 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  92 ----------------AAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQL 155
Cdd:COG4597   251 kgfnfrggltlspefvALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQY 330

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1553139769 156 TLTLLGTSIVSAISAKELTMAGA-TIESQSFRSLETFLVVAAIYICI 201
Cdd:COG4597   331 LNLTKNSSLAVAIGYPDLVSVFAgTTLNQTGQAIEIIAITMAVYLTI 377
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
17-219 1.32e-10

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 59.42  E-value: 1.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  17 LVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLPYA-----------GV 85
Cdd:PRK15135    9 ILQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQIAlnsvtealgvgQI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  86 KLNADQAAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGTSIV 165
Cdd:PRK15135   89 DIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALV 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1553139769 166 SAISAKELTMAGATIESQSFRSLETFLVVAAIYICITFAFRFVYWliglWLFRR 219
Cdd:PRK15135  169 SLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLL----WLERR 218
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
17-202 1.70e-09

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 56.22  E-value: 1.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  17 LVSGAINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFG----------------- 79
Cdd:PRK11123    7 LASAAGMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYFGssqllltlsdgftlnlg 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  80 LPYAGVKLNADQ-------AAIFAVSLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALT 152
Cdd:PRK11123   87 FVQIPVQMDIENfevspflCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLG 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1553139769 153 GQLTLTLLGTSIVSAISAKELTMAGATIESQSFRSLETFLVVAAIYICIT 202
Cdd:PRK11123  167 NQWLVLLKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVIT 216
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 21-205 1.86e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 55.36  E-value: 1.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  21 AINTVVLSAEAIAIGLTIGLCVALARFSGPVWCRFISACYVEGFRNTPLLVQLFLIYFGLPYAGVKLNADQ---AAIFAV 97
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGlglPALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  98 SLNLGAYSTEIFRAGLMAIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGTSIVSAISAKELTMAG 177
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                         170       180
                  ....*....|....*....|....*...
gi 1553139769 178 ATIESQSFRSLETFLVVAAIYICITFAF 205
Cdd:cd06261   161 TGLLLIFAILFPGDLGVAAAVALILLLL 188
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 35-209 9.06e-04

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 38.82  E-value: 9.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769  35 GLTIGLCVALARFSgpvWCRFISACYVEGFRNTPLLVQLFLIYFGLPYAGVKLNAdQAAIFAVSLNLGAYSTEIFRAGLM 114
Cdd:pfam00528   1 GIPLGIIAALRRGR---RLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGI-LPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553139769 115 AIPKTQIQAGLALGMSQIQVMRYVVLIPALRIIYPALTGQLTLTLLGTSIVSAISAKE---LTMAGATIESQSFRSLETF 191
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPglgLLLIEAILGYDYPEIQGPV 156

                         170
                  ....*....|....*...
gi 1553139769 192 LVVAAIYICITFAFRFVY 209
Cdd:pfam00528 157 LAAALILLLLNLLVDILQ 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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