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Conserved domains on  [gi|1553180212|ref|WP_127629822|]
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adenylate/guanylate cyclase domain-containing protein, partial [Sinorhizobium medicae]

Protein Classification

adenylate/guanylate cyclase domain-containing protein( domain architecture ID 11573933)

adenylate/guanylate cyclase domain-containing protein with a TolB_N domain and tetratricopeptide (TPR) repeats, may function as an adenylate cyclase, catalyzing the synthesis of 3',5'-cyclic AMP, or as a guanylate cyclase, catalyzing the synthesis of 3',5'-cyclic GMP

CATH:  3.30.70.1230|1.25.40.10
EC:  2.7.7.-
Gene Ontology:  GO:0046872|GO:0016779|GO:0005515
PubMed:  17236651|9914257|22404999|21153002
SCOP:  4001316|4001344

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TolBN COG5616
TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];
182-314 1.50e-57

TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];


:

Pssm-ID: 444347  Cd Length: 135  Bit Score: 187.40  E-value: 1.50e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 182 RPRPDMKRPSIAVLPFVNLSSVDEQEHFSDGFTEELISTLARCRWLRVVARNSSFTFKGVTVDVRKVASDLGVKYVIEGS 261
Cdd:COG5616     3 PAPAAPDRPSIAVLPFENLSGDPEQEYFADGLTEELITALSRLRGLRVIARTSSFAFKGRAVDLREIARELGVRYVLEGS 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1553180212 262 IRRAANRIRITAQLLSGETGMLLWAERYDRMLDDVFVLQDEIAGQITGTVEPE 314
Cdd:COG5616    83 VRRSGDRVRVTAQLIDAATGRHLWSERYDRDLDDLFALQDEIARAIAAALAPR 135
CHD cd07302
cyclase homology domain; Catalytic domains of the mononucleotidyl cyclases (MNC's), also ...
 5-164 7.52e-28

cyclase homology domain; Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.


:

Pssm-ID: 143636 [Multi-domain]  Cd Length: 177  Bit Score: 109.59  E-value: 7.52e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212   5 AAILDADVVGYSRLM-GLDEAGTYRAVKHCHNAFIlPLVEAHNGRIVKQAGDGMLAEF-------ASLLDAVACAIAIQR 76
Cdd:cd07302     2 VTVLFADIVGFTALSeRLGPEELVELLNEYFSAFD-EIIERHGGTVDKTIGDAVMAVFglpgaheDHAERAVRAALEMQE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212  77 TMHD-QAGSAETERLELRIGVHLGDIVAD-------DGDIHGEGIAVAGHLQEMAPPGGICVSQQVYDQVSSKlDIQMGD 148
Cdd:cd07302    81 ALAElNAEREGGPPLRLRIGIHTGPVVAGvvgserpEYTVIGDTVNLAARLESLAKPGQILVSEATYELLGDA-GFEFEE 159

                         170
                  ....*....|....*.
gi 1553180212 149 LGCKTFADIPGPLHVW 164
Cdd:cd07302   160 LGEVELKGKSGPVRVY 175
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
363-512 3.07e-20

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 90.07  E-value: 3.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 363 IDLEPAFAQAYARLAYVHIQLGWYgpleergdriADATALAERATALDDREPAAHLALGRARALGGQPERGIEHLRNALR 442
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRY----------EEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 443 LVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLWtfhNMVAIAQYQAGRFAQAAEAARTSL 512
Cdd:COG0457    71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL---YNLGLALLELGRYDEAIEAYERAL 137
 
Name Accession Description Interval E-value
TolBN COG5616
TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];
182-314 1.50e-57

TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];


Pssm-ID: 444347  Cd Length: 135  Bit Score: 187.40  E-value: 1.50e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 182 RPRPDMKRPSIAVLPFVNLSSVDEQEHFSDGFTEELISTLARCRWLRVVARNSSFTFKGVTVDVRKVASDLGVKYVIEGS 261
Cdd:COG5616     3 PAPAAPDRPSIAVLPFENLSGDPEQEYFADGLTEELITALSRLRGLRVIARTSSFAFKGRAVDLREIARELGVRYVLEGS 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1553180212 262 IRRAANRIRITAQLLSGETGMLLWAERYDRMLDDVFVLQDEIAGQITGTVEPE 314
Cdd:COG5616    83 VRRSGDRVRVTAQLIDAATGRHLWSERYDRDLDDLFALQDEIARAIAAALAPR 135
CHD cd07302
cyclase homology domain; Catalytic domains of the mononucleotidyl cyclases (MNC's), also ...
 5-164 7.52e-28

cyclase homology domain; Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.


Pssm-ID: 143636 [Multi-domain]  Cd Length: 177  Bit Score: 109.59  E-value: 7.52e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212   5 AAILDADVVGYSRLM-GLDEAGTYRAVKHCHNAFIlPLVEAHNGRIVKQAGDGMLAEF-------ASLLDAVACAIAIQR 76
Cdd:cd07302     2 VTVLFADIVGFTALSeRLGPEELVELLNEYFSAFD-EIIERHGGTVDKTIGDAVMAVFglpgaheDHAERAVRAALEMQE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212  77 TMHD-QAGSAETERLELRIGVHLGDIVAD-------DGDIHGEGIAVAGHLQEMAPPGGICVSQQVYDQVSSKlDIQMGD 148
Cdd:cd07302    81 ALAElNAEREGGPPLRLRIGIHTGPVVAGvvgserpEYTVIGDTVNLAARLESLAKPGQILVSEATYELLGDA-GFEFEE 159

                         170
                  ....*....|....*.
gi 1553180212 149 LGCKTFADIPGPLHVW 164
Cdd:cd07302   160 LGEVELKGKSGPVRVY 175
AcyC COG2114
Adenylate cyclase, class 3 [Signal transduction mechanisms];
2-164 8.56e-26

Adenylate cyclase, class 3 [Signal transduction mechanisms];


Pssm-ID: 441717 [Multi-domain]  Cd Length: 407  Bit Score: 109.12  E-value: 8.56e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212   2 RRLAAILDADVVGYSRLMGLDEAGTYRAVKHCHNAFILPLVEAHNGRIVKQAGDGMLAEFAS-------LLDAVACAIAI 74
Cdd:COG2114   220 RREVTVLFADIVGFTALSERLGPEELVELLNRYFSAMVEIIERHGGTVDKFIGDGVMAVFGApvaredhAERAVRAALAM 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212  75 QRTMHD---QAGSAETERLELRIGVHLGDIVAD--------DGDIHGEGIAVAGHLQEMAPPGGICVSQQVYDQVSSKLD 143
Cdd:COG2114   300 QEALAElnaELPAEGGPPLRVRIGIHTGEVVVGnigsedrlDYTVIGDTVNLAARLESLAKPGEILVSEATYDLLRDRFE 379

                         170       180
                  ....*....|....*....|.
gi 1553180212 144 IQmgDLGCKTFADIPGPLHVW 164
Cdd:COG2114   380 FR--ELGEVRLKGKAEPVEVY 398
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
363-512 3.07e-20

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 90.07  E-value: 3.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 363 IDLEPAFAQAYARLAYVHIQLGWYgpleergdriADATALAERATALDDREPAAHLALGRARALGGQPERGIEHLRNALR 442
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRY----------EEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 443 LVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLWtfhNMVAIAQYQAGRFAQAAEAARTSL 512
Cdd:COG0457    71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL---YNLGLALLELGRYDEAIEAYERAL 137
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 321-507 5.12e-11

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 65.49  E-value: 5.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 321 AALRGQSATDMDAWNIYLKGLWHLYKFDLENLRISkelFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADAT 400
Cdd:TIGR02917 453 AAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREA---FEKALSIEPDFFPAAANLARIDIQEG----------NPDDAI 519

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 401 ALAERATALDDREPAAHLALGRARALGGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPR 480
Cdd:TIGR02917 520 QRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPD 599

                         170       180
                  ....*....|....*....|....*..
gi 1553180212 481 DPHLWTfhnMVAIAQYQAGRFAQAAEA 507
Cdd:TIGR02917 600 SPEAWL---MLGRAQLAAGDLNKAVSS 623
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
182-479 1.49e-09

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 60.25  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 182 RPRPDMKRPSIAVLPFVNLSSVDEQE-HFsdgfteELISTLARCRWLRVVARNSSFTFKGVTV-DVRKVASDLGVKYVIE 259
Cdd:PRK12370  114 PPAPQPTTHTLAILPFQMQDQVQSESlHY------SIVKGLSQYAPFGLSVLPVTITKNCRSVkDILELMDQLRPDYYIS 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 260 GSIRRAANRIRITAQLLSGETGMLLWAERYDRMLDD-VFVLQDEIAG----QITGtvepelgfIEFAALRGQSATDMDAW 334
Cdd:PRK12370  188 GQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQpASLLQNKIANlllrCIPG--------LRWDTKQISELNSIDST 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 335 NIYLKGLWHLYKFDLENLRISKELFERAIDLEPAFAQAYARLAYVHIQLGWYGpLEERGDRIADATALAERATALDDREP 414
Cdd:PRK12370  260 MVYLRGKHELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCALAECYLSMAQMG-IFDKQNAMIKAKEHAIKATELDHNNP 338

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1553180212 415 AAHLALGRARALGGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSP 479
Cdd:PRK12370  339 QALGLLGLINTIHSEYIVGSLLFKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLKLDP 403
StaR_like cd05804
StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member ...
 365-512 5.80e-05

StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been speculated that StaR could be a flavoprotein hydroxylating a tyrosine sidechain. Some family members have been annotated as proteins containing tetratricopeptide (TPR) repeats, which may at least indicate mostly alpha-helical secondary structure.


Pssm-ID: 100115 [Multi-domain]  Cd Length: 355  Bit Score: 45.35  E-value: 5.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 365 LEPAFAQAYARLAYVHIQLGwygpleERGDRIADATALAER-ATALDDREpAAHLALGRArALGGQPERGIEHLRNALRL 443
Cdd:cd05804     1 ADPDFALGHAAAALLLLLGG------ERPAAAAKAAAAAQAlAARATERE-RAHVEALSA-WIAGDLPKALALLEQLLDD 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1553180212 444 VP------SFAQGHFALGQalcYVGRPEegitaiNEAFRLSPRDPHL---WTFHNMVAIAQYQAGRFAQAAEAARTSL 512
Cdd:cd05804    73 YPrdllalKLHLGAFGLGD---FSGMRD------HVARVLPLWAPENpdyWYLLGMLAFGLEEAGQYDRAEEAARRAL 141
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 357-423 1.92e-04

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 43.62  E-value: 1.92e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1553180212 357 ELFERAIDLEPAFAQAYARLAYVHIQLGWYgpleergdriADATALAERATALDDREPAAHLALGRA 423
Cdd:PLN03088   23 DLYTQAIDLDPNNAELYADRAQANIKLGNF----------TEAVADANKAIELDPSLAKAYLRKGTA 79
TAtT pfam16811
TRAP transporter T-component; TAtT is a family of one component, the T-component, of a sub-set ...
 333-458 3.59e-04

TRAP transporter T-component; TAtT is a family of one component, the T-component, of a sub-set of TRAP-Ts or Tripartite ATP-independent periplasmic transporters. TRAP-Ts are bacterial transport systems implicated in the import of small molecules into the cytoplasm in bacteria. They are all periplasmic lipoproteins. TatT consists of a 13-alpha-helical fold containing cryptic tetratricopeptide repeat motifs (cTPRs) and encompassing a pore, ie is a water-soluble trimer whose protomers are each perforated by a pore. It forms a complex with a P component, and a putative ligand-binding cleft of TatPT aligns with the pore of TatT. Family TatPT is represented by some members of pfam03480.


Pssm-ID: 435596 [Multi-domain]  Cd Length: 263  Bit Score: 42.33  E-value: 3.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 333 AWNIYLKGLWHLYKFDLENLR-ISKELFERAI------DLEPAFAQAYARLAYvhIQLGWYGPleERGDRIADATALAER 405
Cdd:pfam16811  77 ARDYALRALETAYDGFTCALRsGPADDLDAALaklkkdDVPALYWAAAAWASA--IALNPLDP--ALLADLPKVEAMMER 152

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 406 ATALDDR--EPAAHLALG-----RARALGGQPERGIEHLRNALRLvpsfAQGHFALGQAL 458
Cdd:pfam16811 153 VLELDESyyYGAAHLFLGvyygsRPPSLGGDPERARAHFERALEL----SGGKNLGPYVL 208
FlgO pfam17680
FlgO protein; This entry represents the FlgO protein. Mutation of this protein in Vibrio ...
 184-277 1.54e-03

FlgO protein; This entry represents the FlgO protein. Mutation of this protein in Vibrio cholerae has been shown to reduce motility. FlgO is an outer membrane protein that localizes throughout the membrane and not at the flagellar pole. Although FlgO and FlgP do not specifically localize to the flagellum, they are required for flagellar stability. Proteins in this family mostly contain an N-terminal lipoprotein attachment motif.


Pssm-ID: 435970  Cd Length: 130  Bit Score: 38.64  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 184 RPDMKRPSIAVLPFVNLSSVDEQEHFSDGFTEELISTLARCRwLRVV---ARNS-SFTFKGVTV---DVRKVASDLGVKY 256
Cdd:pfam17680  12 DPLLLRRPIAVTSFVDLDDLQQTSTLGRQLSESLITELQQRG-YSVVeykLTDSiRVTEEGEFAlsrDLRELAETQNADY 90

                          90       100
                  ....*....|....*....|.
gi 1553180212 257 VIEGSIRRAANRIRITAQLLS 277
Cdd:pfam17680  91 VLVGTYTVTRDGVLVNARLID 111
CYCc smart00044
Adenylyl- / guanylyl cyclase, catalytic domain; Present in two copies in mammalian adenylyl ...
 5-136 3.28e-03

Adenylyl- / guanylyl cyclase, catalytic domain; Present in two copies in mammalian adenylyl cyclases. Eubacterial homologues are known. Two residues (Asn, Arg) are thought to be involved in catalysis. These cyclases have important roles in a diverse range of cellular processes.


Pssm-ID: 214485  Cd Length: 194  Bit Score: 38.78  E-value: 3.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212    5 AAILDADVVGYSRLMgldEAGTYRAV----KHCHNAFILpLVEAHNGRIVKQAGDGMLAEFASLLDAVA----CAIAIQR 76
Cdd:smart00044  37 VTILFSDIVGFTSLC---STSTPEQVvnllNDLYSRFDQ-IIDRHGGYKVKTIGDAYMVASGLPEEALVdhaeLIADEAL 112

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1553180212   77 TMHDQAGS----AETERLELRIGVHLGDIVAD-DG------DIHGEGIAVAGHLQEMAPPGGICVSQQVYD 136
Cdd:smart00044 113 DMVEELKTvlvqHREEGLRVRIGIHTGPVVAGvVGirmpryCLFGDTVNLASRMESAGDPGQIQVSEETYS 183
BTAD smart01043
Bacterial transcriptional activator domain; Found in the DNRI/REDD/AFSR family of regulators. ...
 389-507 7.19e-03

Bacterial transcriptional activator domain; Found in the DNRI/REDD/AFSR family of regulators. This region of AFSR along with the C terminal region is capable of independently directing actinorhodin production. This family contains TPR repeats.


Pssm-ID: 198111 [Multi-domain]  Cd Length: 145  Bit Score: 37.28  E-value: 7.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212  389 LEERGDRIADATALAERATALDDREPAAHLALGRARALGGQP-ERGIEHLRNALRLVpsFAQGHFALGQALCYVGRPEEg 467
Cdd:smart01043   3 VDRFERLVAAARAALAADPEAALALLEAALALYRGPLLADVPdEDWAEAERERLREL--RLEALEALAEALLALGRHEE- 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1553180212  468 itAINEAFRLSPRDPHLWTFHNMVAIAQYQAGRFAQAAEA 507
Cdd:smart01043  80 --ALALLERLLALDPLRERLHRLLMRALYRAGRRAEALRA 117
 
Name Accession Description Interval E-value
TolBN COG5616
TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];
182-314 1.50e-57

TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];


Pssm-ID: 444347  Cd Length: 135  Bit Score: 187.40  E-value: 1.50e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 182 RPRPDMKRPSIAVLPFVNLSSVDEQEHFSDGFTEELISTLARCRWLRVVARNSSFTFKGVTVDVRKVASDLGVKYVIEGS 261
Cdd:COG5616     3 PAPAAPDRPSIAVLPFENLSGDPEQEYFADGLTEELITALSRLRGLRVIARTSSFAFKGRAVDLREIARELGVRYVLEGS 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1553180212 262 IRRAANRIRITAQLLSGETGMLLWAERYDRMLDDVFVLQDEIAGQITGTVEPE 314
Cdd:COG5616    83 VRRSGDRVRVTAQLIDAATGRHLWSERYDRDLDDLFALQDEIARAIAAALAPR 135
CHD cd07302
cyclase homology domain; Catalytic domains of the mononucleotidyl cyclases (MNC's), also ...
 5-164 7.52e-28

cyclase homology domain; Catalytic domains of the mononucleotidyl cyclases (MNC's), also called cyclase homology domains (CHDs), are part of the class III nucleotidyl cyclases. This class includes eukaryotic and prokaryotic adenylate cyclases (AC's) and guanylate cyclases (GC's). They seem to share a common catalytic mechanism in their requirement for two magnesium ions to bind the polyphosphate moiety of the nucleotide.


Pssm-ID: 143636 [Multi-domain]  Cd Length: 177  Bit Score: 109.59  E-value: 7.52e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212   5 AAILDADVVGYSRLM-GLDEAGTYRAVKHCHNAFIlPLVEAHNGRIVKQAGDGMLAEF-------ASLLDAVACAIAIQR 76
Cdd:cd07302     2 VTVLFADIVGFTALSeRLGPEELVELLNEYFSAFD-EIIERHGGTVDKTIGDAVMAVFglpgaheDHAERAVRAALEMQE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212  77 TMHD-QAGSAETERLELRIGVHLGDIVAD-------DGDIHGEGIAVAGHLQEMAPPGGICVSQQVYDQVSSKlDIQMGD 148
Cdd:cd07302    81 ALAElNAEREGGPPLRLRIGIHTGPVVAGvvgserpEYTVIGDTVNLAARLESLAKPGQILVSEATYELLGDA-GFEFEE 159

                         170
                  ....*....|....*.
gi 1553180212 149 LGCKTFADIPGPLHVW 164
Cdd:cd07302   160 LGEVELKGKSGPVRVY 175
AcyC COG2114
Adenylate cyclase, class 3 [Signal transduction mechanisms];
2-164 8.56e-26

Adenylate cyclase, class 3 [Signal transduction mechanisms];


Pssm-ID: 441717 [Multi-domain]  Cd Length: 407  Bit Score: 109.12  E-value: 8.56e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212   2 RRLAAILDADVVGYSRLMGLDEAGTYRAVKHCHNAFILPLVEAHNGRIVKQAGDGMLAEFAS-------LLDAVACAIAI 74
Cdd:COG2114   220 RREVTVLFADIVGFTALSERLGPEELVELLNRYFSAMVEIIERHGGTVDKFIGDGVMAVFGApvaredhAERAVRAALAM 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212  75 QRTMHD---QAGSAETERLELRIGVHLGDIVAD--------DGDIHGEGIAVAGHLQEMAPPGGICVSQQVYDQVSSKLD 143
Cdd:COG2114   300 QEALAElnaELPAEGGPPLRVRIGIHTGEVVVGnigsedrlDYTVIGDTVNLAARLESLAKPGEILVSEATYDLLRDRFE 379

                         170       180
                  ....*....|....*....|.
gi 1553180212 144 IQmgDLGCKTFADIPGPLHVW 164
Cdd:COG2114   380 FR--ELGEVRLKGKAEPVEVY 398
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
363-512 3.07e-20

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 90.07  E-value: 3.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 363 IDLEPAFAQAYARLAYVHIQLGWYgpleergdriADATALAERATALDDREPAAHLALGRARALGGQPERGIEHLRNALR 442
Cdd:COG0457     1 LELDPDDAEAYNNLGLAYRRLGRY----------EEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALE 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 443 LVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLWtfhNMVAIAQYQAGRFAQAAEAARTSL 512
Cdd:COG0457    71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL---YNLGLALLELGRYDEAIEAYERAL 137
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 348-513 6.99e-19

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 90.05  E-value: 6.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 348 DLENLRISKELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDREPAAHLALGRARALG 427
Cdd:COG3914    90 ALGRYEEALALYRRALALNPDNAEALFNLGNLLLALG----------RLEEALAALRRALALNPDFAEAYLNLGEALRRL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 428 GQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLwtFHNMVAIAQYQAGRFAQAAEA 507
Cdd:COG3914   160 GRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADA--HSNLLFALRQACDWEVYDRFE 237


                  ....*.
gi 1553180212 508 ARTSLL 513
Cdd:COG3914   238 ELLAAL 243
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 333-512 1.19e-18

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 89.28  E-value: 1.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 333 AWNIYLKGLWHLYKFDLENLRISKELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDR 412
Cdd:COG3914    41 LGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALG----------RYEEALALYRRALALNPD 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 413 EPAAHLALGRARALGGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLwtfHNMVA 492
Cdd:COG3914   111 NAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEA---LNNLG 187

                         170       180
                  ....*....|....*....|
gi 1553180212 493 IAQYQAGRFAQAAEAARTSL 512
Cdd:COG3914   188 NALQDLGRLEEAIAAYRRAL 207
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
357-509 1.06e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 82.75  E-value: 1.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 357 ELFERAIDLEPAFAQAYARLAYVHIQLGWYgpleergdriADATALAERATALDDREPAAHLALGRARALGGQPERGIEH 436
Cdd:COG0457    29 EDYEKALELDPDDAEALYNLGLAYLRLGRY----------EEALADYEQALELDPDDAEALNNLGLALQALGRYEEALED 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1553180212 437 LRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLWtfhNMVAIAQYQAGRFAQAAEAAR 509
Cdd:COG0457    99 YDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADAL---YNLGIALEKLGRYEEALELLE 168
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 344-481 5.82e-17

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 77.54  E-value: 5.82e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 344 LYKFDLENLRISKELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDREPAAHLALGRA 423
Cdd:COG4783    12 QALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLG----------DLDEAIVLLHEALELDPDEPEARLNLGLA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1553180212 424 RALGGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRD 481
Cdd:COG4783    82 LLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
347-509 9.11e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.89  E-value: 9.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 347 FDLENLRISKELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDREPAAHLALGRARAL 426
Cdd:COG0457    53 LRLGRYEEALADYEQALELDPDDAEALNNLGLALQALG----------RYEEALEDYDKALELDPDDAEALYNLGLALLE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 427 GGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLWTFHNMVAIAQYQAGRFAQAAE 506
Cdd:COG0457   123 LGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLA 202


                  ...
gi 1553180212 507 AAR 509
Cdd:COG0457   203 LEQ 205
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 357-494 4.89e-14

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 68.88  E-value: 4.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 357 ELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDREPAAHLALGRARALGGQPERGIEH 436
Cdd:COG4235     4 ARLRQALAANPNDAEGWLLLGRAYLRLG----------RYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEEL 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1553180212 437 LRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLWTFHNMVAIA 494
Cdd:COG4235    74 LERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAEA 131
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 370-512 1.34e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 67.91  E-value: 1.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 370 AQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDREPAAHLALGRARALGGQPERGIEHLRNALRLVPSFAQ 449
Cdd:COG4783     4 AEALYALAQALLLAG----------DYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPE 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1553180212 450 GHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLWtfhNMVAIAQYQAGRFAQAAEAARTSL 512
Cdd:COG4783    74 ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAY---LRLARAYRALGRPDEAIAALEKAL 133
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 398-507 2.83e-13

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 66.57  E-value: 2.83e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 398 DATALAERATALDDREPAAHLALGRARALGGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRL 477
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1553180212 478 SPRDPHLWTFHnmvAIAQYQAGRFAQAAEA 507
Cdd:COG4235    81 DPDNPEALYLL---GLAAFQQGDYAEAIAA 107
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 357-512 1.84e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 67.83  E-value: 1.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 357 ELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDREPAAHLALGRARALGGQPERGIEH 436
Cdd:COG2956   131 EVLERLLKLGPENAHAYCELAELYLEQG----------DYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAA 200

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1553180212 437 LRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDphlwTFHNMVAIAQYQAGRFAQAAEAARTSL 512
Cdd:COG2956   201 LERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD----DLLLALADLLERKEGLEAALALLERQL 272
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 356-512 1.93e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 67.45  E-value: 1.93e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 356 KELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDREPAAHLALGRARALGGQPERGIE 435
Cdd:COG2956    96 EELLEKLLELDPDDAEALRLLAEIYEQEG----------DWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIE 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1553180212 436 HLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLwtfHNMVAIAQYQAGRFAQAAEAARTSL 512
Cdd:COG2956   166 ALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPA---LPRLAELYEKLGDPEEALELLRKAL 239
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 333-512 1.31e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 65.14  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 333 AWNIYLKGLWHLYKfdlENLRISKELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDR 412
Cdd:COG2956     8 ALGWYFKGLNYLLN---GQPDKAIDLLEEALELDPETVEAHLALGNLYRRRG----------EYDRAIRIHQKLLERDPD 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 413 EPAAHLALGRARALGGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHlwtFHNMVA 492
Cdd:COG2956    75 RAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH---AYCELA 151

                         170       180
                  ....*....|....*....|
gi 1553180212 493 IAQYQAGRFAQAAEAARTSL 512
Cdd:COG2956   152 ELYLEQGDYDEAIEALEKAL 171
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 357-512 1.97e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 64.75  E-value: 1.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 357 ELFERAIDLEPAFAQAYARLAYVHIQLGWYgpleergdriADATALAERATALDDREPAAHLALGRARALGGQPERGIEH 436
Cdd:COG2956    63 RIHQKLLERDPDRAEALLELAQDYLKAGLL----------DRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEV 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1553180212 437 LRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLWTfhnMVAIAQYQAGRFAQAAEAARTSL 512
Cdd:COG2956   133 LERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALL---LLAELYLEQGDYEEAIAALERAL 205
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 321-507 5.12e-11

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 65.49  E-value: 5.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 321 AALRGQSATDMDAWNIYLKGLWHLYKFDLENLRISkelFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADAT 400
Cdd:TIGR02917 453 AAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREA---FEKALSIEPDFFPAAANLARIDIQEG----------NPDDAI 519

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 401 ALAERATALDDREPAAHLALGRARALGGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPR 480
Cdd:TIGR02917 520 QRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPD 599

                         170       180
                  ....*....|....*....|....*..
gi 1553180212 481 DPHLWTfhnMVAIAQYQAGRFAQAAEA 507
Cdd:TIGR02917 600 SPEAWL---MLGRAQLAAGDLNKAVSS 623
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
344-512 1.12e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 58.39  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 344 LYKFDLENLRISKELFERAIDLEPAFAqAYARLAYVHIQLGWYGPLEERGDRIADATALAERATALDDREP---AAHLAL 420
Cdd:COG4785     1 LYALALALLLALALAAAAASKAAILLA-ALLFAAVLALAIALADLALALAAAALAAAALAAERIDRALALPdlaQLYYER 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 421 GRARALGGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRdpHLWTFHNMvAIAQYQAGR 500
Cdd:COG4785    80 GVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPD--YAYAYLNR-GIALYYLGR 156

                         170
                  ....*....|..
gi 1553180212 501 FAQAAEAARTSL 512
Cdd:COG4785   157 YELAIADLEKAL 168
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
182-479 1.49e-09

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 60.25  E-value: 1.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 182 RPRPDMKRPSIAVLPFVNLSSVDEQE-HFsdgfteELISTLARCRWLRVVARNSSFTFKGVTV-DVRKVASDLGVKYVIE 259
Cdd:PRK12370  114 PPAPQPTTHTLAILPFQMQDQVQSESlHY------SIVKGLSQYAPFGLSVLPVTITKNCRSVkDILELMDQLRPDYYIS 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 260 GSIRRAANRIRITAQLLSGETGMLLWAERYDRMLDD-VFVLQDEIAG----QITGtvepelgfIEFAALRGQSATDMDAW 334
Cdd:PRK12370  188 GQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQpASLLQNKIANlllrCIPG--------LRWDTKQISELNSIDST 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 335 NIYLKGLWHLYKFDLENLRISKELFERAIDLEPAFAQAYARLAYVHIQLGWYGpLEERGDRIADATALAERATALDDREP 414
Cdd:PRK12370  260 MVYLRGKHELNQYTPYSLQQALKLLTQCVNMSPNSIAPYCALAECYLSMAQMG-IFDKQNAMIKAKEHAIKATELDHNNP 338

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1553180212 415 AAHLALGRARALGGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSP 479
Cdd:PRK12370  339 QALGLLGLINTIHSEYIVGSLLFKQANLLSPISADIKYYYGWNLFMAGQLEEALQTINECLKLDP 403
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 347-445 2.65e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.40  E-value: 2.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 347 FDLENLRISKELFERAIDLEPAFAQAYARLAYVHIQLGWYgpleergdriADATALAERATALDDREPAAHLALGRARAL 426
Cdd:COG4235    28 LRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDT----------EEAEELLERALALDPDNPEALYLLGLAAFQ 97

                          90
                  ....*....|....*....
gi 1553180212 427 GGQPERGIEHLRNALRLVP 445
Cdd:COG4235    98 QGDYAEAIAAWQKLLALLP 116
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 361-512 3.79e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 55.74  E-value: 3.79e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 361 RAIDLEPAFAQAYARLAYVHIQLGWYGPLEERGDRIADATALAERATALDDREPAAHLALGRARALGGQPERGIEHLRNA 440
Cdd:COG5010     1 ARALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1553180212 441 LRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPhlwTFHNMVAIAQYQAGRFAQAAEAARTSL 512
Cdd:COG5010    81 LQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNP---NAYSNLAALLLSLGQDDEAKAALQRAL 149
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 337-479 4.82e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 55.35  E-value: 4.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 337 YLKGLWHLYKFDLENLRISKELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDREPAA 416
Cdd:COG5010    21 RTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLG----------DFEESLALLEQALQLDPNNPEL 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1553180212 417 HLALGRARALGGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSP 479
Cdd:COG5010    91 YYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
365-487 1.18e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 55.69  E-value: 1.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 365 LEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDREPAAHLALGRARALGGQPERGIEHLRNALRLV 444
Cdd:COG4785    68 ALPDLAQLYYERGVAYDSLG----------DYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELD 137

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1553180212 445 PSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDP--HLWTF 487
Cdd:COG4785   138 PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPerALWLY 182
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 376-509 4.24e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.35  E-value: 4.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 376 LAYVHIQLGWY--GPLEERGDRIADATALAERATALDDREPAAHLALGRARALGGQPERGIEHLRNALRLVPSFAQGHFA 453
Cdd:COG2956     2 LLPVAAALGWYfkGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1553180212 454 LGQALCYVGRPEEGITAINEAFRLSPRDPHLWtfHNMVAIAQyQAGRFAQAAEAAR 509
Cdd:COG2956    82 LAQDYLKAGLLDRAEELLEKLLELDPDDAEAL--RLLAEIYE-QEGDWEKAIEVLE 134
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
356-449 1.09e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.78  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 356 KELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALaERATALDDREPAAHLALGRARALGGQPERGIE 435
Cdd:COG3063    12 EEYYEKALELDPDNADALNNLGLLLLEQG----------RYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALA 80

                          90
                  ....*....|....
gi 1553180212 436 HLRNALRLVPSFAQ 449
Cdd:COG3063    81 YLERALELDPSALR 94
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
389-480 1.17e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.78  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 389 LEERGDrIADATALAERATALDDREPAAHLALGRARALGGQPERGIEhLRNALRLVPSFAQGHFALGQALCYVGRPEEGI 468
Cdd:COG3063     2 YLKLGD-LEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                          90
                  ....*....|..
gi 1553180212 469 TAINEAFRLSPR 480
Cdd:COG3063    80 AYLERALELDPS 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 338-512 1.30e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 54.32  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 338 LKGLWHLykfDLENLRISKELFERAIDLEPAFAQAYARLAYVHiqlgwygpLEErgDRIADATALAERATALDDREPAAH 417
Cdd:TIGR02917 130 LRGLAYL---GLGQLELAQKSYEQALAIDPRSLYAKLGLAQLA--------LAE--NRFDEARALIDEVLTADPGNVDAL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 418 LALGRARALGGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLwtfHNMVAIAQYQ 497
Cdd:TIGR02917 197 LLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLA---HYLKALVDFQ 273

                         170
                  ....*....|....*
gi 1553180212 498 AGRFAQAAEAARTSL 512
Cdd:TIGR02917 274 KKNYEDARETLQDAL 288
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
332-509 1.33e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.70  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 332 DAWNIYLKGLWHLYKFDLENlriSKELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDD 411
Cdd:COG0457    75 DAEALNNLGLALQALGRYEE---ALEDYDKALELDPDDAEALYNLGLALLELG----------RYDEAIEAYERALELDP 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 412 REPAAHLALGRARALGGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLWTFHNMV 491
Cdd:COG0457   142 DDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAE 221

                         170
                  ....*....|....*...
gi 1553180212 492 AIAQYQAGRFAQAAEAAR 509
Cdd:COG0457   222 LLLLALALLLALRLAALA 239
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 332-445 1.49e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 51.11  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 332 DAWNIYLKGLWHLYKFDLENLRISKELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDD 411
Cdd:COG5010    50 LAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSG----------DKDEAKEYYEKALALSP 119

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1553180212 412 REPAAHLALGRARALGGQPERGIEHLRNALRLVP 445
Cdd:COG5010   120 DNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 434-512 1.70e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.00  E-value: 1.70e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1553180212 434 IEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLWTfhnMVAIAQYQAGRFAQAAEAARTSL 512
Cdd:COG4235     3 IARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALL---DLAEALLAAGDTEEAEELLERAL 78
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 347-509 2.48e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.55  E-value: 2.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 347 FDLENLRISKELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDREPAAHLALGRARAL 426
Cdd:TIGR02917 306 YQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLG----------RVDEAIATLSPALGLDPDDPAALSLLGEAYLA 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 427 GGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLwtfHNMVAIAQYQAGRFAQAAE 506
Cdd:TIGR02917 376 LGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRA---DLLLILSYLRSGQFDKALA 452


                  ...
gi 1553180212 507 AAR 509
Cdd:TIGR02917 453 AAK 455
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
428-512 5.04e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.86  E-value: 5.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 428 GQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGItAINEAFRLSPRDPhlwTFHNMVAIAQYQAGRFAQAAEA 507
Cdd:COG3063     6 GDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNA---EALLNLAELLLELGDYDEALAY 81


                  ....*
gi 1553180212 508 ARTSL 512
Cdd:COG3063    82 LERAL 86
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 358-455 4.09e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.23  E-value: 4.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 358 LFERAIDLEPAFAQAYARLAYVHIQLgwYGPleergdriaDATALAERATALDDREPAAHLALGRARALGGQPERGIEHL 437
Cdd:TIGR02917 792 HYQTVVKKAPDNAVVLNNLAWLYLEL--KDP---------RALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLL 860

                          90       100
                  ....*....|....*....|
gi 1553180212 438 RNALRLVPSFA--QGHFALG 455
Cdd:TIGR02917 861 RKAVNIAPEAAaiRYHLALA 880
StaR_like cd05804
StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member ...
 365-512 5.80e-05

StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been speculated that StaR could be a flavoprotein hydroxylating a tyrosine sidechain. Some family members have been annotated as proteins containing tetratricopeptide (TPR) repeats, which may at least indicate mostly alpha-helical secondary structure.


Pssm-ID: 100115 [Multi-domain]  Cd Length: 355  Bit Score: 45.35  E-value: 5.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 365 LEPAFAQAYARLAYVHIQLGwygpleERGDRIADATALAER-ATALDDREpAAHLALGRArALGGQPERGIEHLRNALRL 443
Cdd:cd05804     1 ADPDFALGHAAAALLLLLGG------ERPAAAAKAAAAAQAlAARATERE-RAHVEALSA-WIAGDLPKALALLEQLLDD 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1553180212 444 VP------SFAQGHFALGQalcYVGRPEegitaiNEAFRLSPRDPHL---WTFHNMVAIAQYQAGRFAQAAEAARTSL 512
Cdd:cd05804    73 YPrdllalKLHLGAFGLGD---FSGMRD------HVARVLPLWAPENpdyWYLLGMLAFGLEEAGQYDRAEEAARRAL 141
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 332-506 8.95e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.46  E-value: 8.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 332 DAWNiyLKGLwhlYKFDLENLRISKELFERAIDLEPAFAQAYARLAYVHIQLGWYGPLEergdriADATALAERATaldd 411
Cdd:TIGR02917 194 DALL--LKGD---LLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAE------KHADALLKKAP---- 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 412 REPAAHLALGRARALGGQPERGIEHLRNALRLVPSFAQG-------HFALG---QALCYV-------------------- 461
Cdd:TIGR02917 259 NSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPAlllagasEYQLGnleQAYQYLnqilkyapnshqarrllasi 338

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1553180212 462 ----GRPEEGITAINEAFRLSPRDPHLWTfhnMVAIAQYQAGRFAQAAE 506
Cdd:TIGR02917 339 qlrlGRVDEAIATLSPALGLDPDDPAALS---LLGEAYLALGDFEKAAE 384
Nucleotidyl_cyc_III cd07556
Class III nucleotidyl cyclases; Class III nucleotidyl cyclases are the largest, most diverse ...
 4-128 1.39e-04

Class III nucleotidyl cyclases; Class III nucleotidyl cyclases are the largest, most diverse group of nucleotidyl cyclases (NC's) containing prokaryotic and eukaryotic proteins. They can be divided into two major groups; the mononucleotidyl cyclases (MNC's) and the diguanylate cyclases (DGC's). The MNC's, which include the adenylate cyclases (AC's) and the guanylate cyclases (GC's), have a conserved cyclase homology domain (CHD), while the DGC's have a conserved GGDEF domain, named after a conserved motif within this subgroup. Their products, cyclic guanylyl and adenylyl nucleotides, are second messengers that play important roles in eukaryotic signal transduction and prokaryotic sensory pathways.


Pssm-ID: 143637 [Multi-domain]  Cd Length: 133  Bit Score: 41.96  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212   4 LAAILDADVVGYSRLMGLDEAGTYRAVKHCHNAFILPLVEAHNGRIVKQAGDGMLAEF--ASLLDAVACAIAIQRTMhDQ 81
Cdd:cd07556     1 PVTILFADIVGFTSLADALGPDEGDELLNELAGRFDSLIRRSGDLKIKTIGDEFMVVSglDHPAAAVAFAEDMREAV-SA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1553180212  82 AGSAETERLELRIGVHLGDIVAD------DGDIHGEGIAVAGHLQEMAPPGGI 128
Cdd:cd07556    80 LNQSEGNPVRVRIGIHTGPVVVGvigsrpQYDVWGALVNLASRMESQAKAGQV 132
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 359-510 1.91e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.30  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 359 FERAIDLEPA--------FAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDREPAAHLALGRARALGGQP 430
Cdd:TIGR02917 106 FQQVLDELPGktllddegAAELLALRGLAYLGLG----------QLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRF 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 431 ERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLWTFHNMVAIaqyQAGRFAQAAEAART 510
Cdd:TIGR02917 176 DEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILI---EAGEFEEAEKHADA 252
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 357-423 1.92e-04

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 43.62  E-value: 1.92e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1553180212 357 ELFERAIDLEPAFAQAYARLAYVHIQLGWYgpleergdriADATALAERATALDDREPAAHLALGRA 423
Cdd:PLN03088   23 DLYTQAIDLDPNNAELYADRAQANIKLGNF----------TEAVADANKAIELDPSLAKAYLRKGTA 79
TAtT pfam16811
TRAP transporter T-component; TAtT is a family of one component, the T-component, of a sub-set ...
 333-458 3.59e-04

TRAP transporter T-component; TAtT is a family of one component, the T-component, of a sub-set of TRAP-Ts or Tripartite ATP-independent periplasmic transporters. TRAP-Ts are bacterial transport systems implicated in the import of small molecules into the cytoplasm in bacteria. They are all periplasmic lipoproteins. TatT consists of a 13-alpha-helical fold containing cryptic tetratricopeptide repeat motifs (cTPRs) and encompassing a pore, ie is a water-soluble trimer whose protomers are each perforated by a pore. It forms a complex with a P component, and a putative ligand-binding cleft of TatPT aligns with the pore of TatT. Family TatPT is represented by some members of pfam03480.


Pssm-ID: 435596 [Multi-domain]  Cd Length: 263  Bit Score: 42.33  E-value: 3.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 333 AWNIYLKGLWHLYKFDLENLR-ISKELFERAI------DLEPAFAQAYARLAYvhIQLGWYGPleERGDRIADATALAER 405
Cdd:pfam16811  77 ARDYALRALETAYDGFTCALRsGPADDLDAALaklkkdDVPALYWAAAAWASA--IALNPLDP--ALLADLPKVEAMMER 152

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 406 ATALDDR--EPAAHLALG-----RARALGGQPERGIEHLRNALRLvpsfAQGHFALGQAL 458
Cdd:pfam16811 153 VLELDESyyYGAAHLFLGvyygsRPPSLGGDPERARAHFERALEL----SGGKNLGPYVL 208
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 452-512 5.33e-04

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 38.47  E-value: 5.33e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1553180212 452 FALGQALCYVGRPEEGITAINEAFRLSPRDPHLWTFHNMVAIAQYQAGRFAQAAEAARTSL 512
Cdd:pfam13432   1 LALARAALRAGDYDDAAAALEAALARFPESPDAAAALLLLGLAALRQGRLAEAAAAYRAAL 61
FlgO pfam17680
FlgO protein; This entry represents the FlgO protein. Mutation of this protein in Vibrio ...
 184-277 1.54e-03

FlgO protein; This entry represents the FlgO protein. Mutation of this protein in Vibrio cholerae has been shown to reduce motility. FlgO is an outer membrane protein that localizes throughout the membrane and not at the flagellar pole. Although FlgO and FlgP do not specifically localize to the flagellum, they are required for flagellar stability. Proteins in this family mostly contain an N-terminal lipoprotein attachment motif.


Pssm-ID: 435970  Cd Length: 130  Bit Score: 38.64  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 184 RPDMKRPSIAVLPFVNLSSVDEQEHFSDGFTEELISTLARCRwLRVV---ARNS-SFTFKGVTV---DVRKVASDLGVKY 256
Cdd:pfam17680  12 DPLLLRRPIAVTSFVDLDDLQQTSTLGRQLSESLITELQQRG-YSVVeykLTDSiRVTEEGEFAlsrDLRELAETQNADY 90

                          90       100
                  ....*....|....*....|.
gi 1553180212 257 VIEGSIRRAANRIRITAQLLS 277
Cdd:pfam17680  91 VLVGTYTVTRDGVLVNARLID 111
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
430-510 2.13e-03

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 39.87  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 430 PERGIEHLRNALRLVPSFAQgHFALGQALCYVGRPEEGITAINEAF-RLSPRDPH-LWTfhnmVAIAQYQAGRFAQAAEA 507
Cdd:COG4700    72 PGRELRELEKALEFADTVQN-RVRLADALLELGRYDEAIELYEEALtGIFADDPHiLLG----LAQALFELGRYAEALET 146


                  ...
gi 1553180212 508 ART 510
Cdd:COG4700   147 LEK 149
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 361-479 2.35e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 40.28  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 361 RAIDLEPAFAQAYARLAyvhIQLGWYGPLEE---------------------RGDRIADATALAERATALDDREPAAHLA 419
Cdd:COG3071   187 RAERRDPELAAAYARAL---IALGDHDEAERllrealkrqwdprlvrlygrlQGGDPAKQLKRAEKWLKKHPNDPDLLLA 263

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 420 LGRARALGGQPERGIEHLRNALRLVPSfAQGHFALGQALCYVGRPEEGITAINEAFRLSP 479
Cdd:COG3071   264 LGRLCLRNQLWGKAREYLEAALALRPS-AEAYAELARLLEQLGDPEEAAEHYRKALALAL 322
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 357-442 3.10e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 3.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 357 ELFERAIDLEPAFAQAYARLAYVHIQLGwygpleergdRIADATALAERATALDDrEPAAHLALGRARALGGQPERGIEH 436
Cdd:COG2956   199 AALERALEQDPDYLPALPRLAELYEKLG----------DPEEALELLRKALELDP-SDDLLLALADLLERKEGLEAALAL 267


                  ....*.
gi 1553180212 437 LRNALR 442
Cdd:COG2956   268 LERQLR 273
CYCc smart00044
Adenylyl- / guanylyl cyclase, catalytic domain; Present in two copies in mammalian adenylyl ...
 5-136 3.28e-03

Adenylyl- / guanylyl cyclase, catalytic domain; Present in two copies in mammalian adenylyl cyclases. Eubacterial homologues are known. Two residues (Asn, Arg) are thought to be involved in catalysis. These cyclases have important roles in a diverse range of cellular processes.


Pssm-ID: 214485  Cd Length: 194  Bit Score: 38.78  E-value: 3.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212    5 AAILDADVVGYSRLMgldEAGTYRAV----KHCHNAFILpLVEAHNGRIVKQAGDGMLAEFASLLDAVA----CAIAIQR 76
Cdd:smart00044  37 VTILFSDIVGFTSLC---STSTPEQVvnllNDLYSRFDQ-IIDRHGGYKVKTIGDAYMVASGLPEEALVdhaeLIADEAL 112

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1553180212   77 TMHDQAGS----AETERLELRIGVHLGDIVAD-DG------DIHGEGIAVAGHLQEMAPPGGICVSQQVYD 136
Cdd:smart00044 113 DMVEELKTvlvqHREEGLRVRIGIHTGPVVAGvVGirmpryCLFGDTVNLASRMESAGDPGQIQVSEETYS 183
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 397-510 5.97e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 38.74  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 397 ADATALAERATALDDREPAAHLALGRARALGGQPERGIEHLRNALRLVPSF------AQGHFALGQalcyvGRPEEGITA 470
Cdd:COG3071    33 ARAEKLLSKAAEHSEAPLLAYLLAARAAQALGDYERRDEYLAQALELAPEAelavllTRAELLLDQ-----GQAEQALAT 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1553180212 471 INEAFRLSPRDPHLWtfhNMVAIAQYQAGRFAQAAEAART 510
Cdd:COG3071   108 LEALRAGAPRHPQVL---RLLLQAYRQLGDWEELLELLPA 144
BTAD smart01043
Bacterial transcriptional activator domain; Found in the DNRI/REDD/AFSR family of regulators. ...
 389-507 7.19e-03

Bacterial transcriptional activator domain; Found in the DNRI/REDD/AFSR family of regulators. This region of AFSR along with the C terminal region is capable of independently directing actinorhodin production. This family contains TPR repeats.


Pssm-ID: 198111 [Multi-domain]  Cd Length: 145  Bit Score: 37.28  E-value: 7.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212  389 LEERGDRIADATALAERATALDDREPAAHLALGRARALGGQP-ERGIEHLRNALRLVpsFAQGHFALGQALCYVGRPEEg 467
Cdd:smart01043   3 VDRFERLVAAARAALAADPEAALALLEAALALYRGPLLADVPdEDWAEAERERLREL--RLEALEALAEALLALGRHEE- 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1553180212  468 itAINEAFRLSPRDPHLWTFHNMVAIAQYQAGRFAQAAEA 507
Cdd:smart01043  80 --ALALLERLLALDPLRERLHRLLMRALYRAGRRAEALRA 117
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 359-505 8.69e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 8.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 359 FERAIDLEPAfAQAYARLAYVHIQLG-----------WygpLEERGDRIADATALAERATALDDREPAA---HLALGRAR 424
Cdd:TIGR02917 726 YRKALKRAPS-SQNAIKLHRALLASGntaeavktleaW---LKTHPNDAVLRTALAELYLAQKDYDKAIkhyQTVVKKAP 801

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1553180212 425 ------------ALGGQPERGIEHLRNALRLVPSFAQGHFALGQALCYVGRPEEGITAINEAFRLSPRDPHLwTFHnmVA 492
Cdd:TIGR02917 802 dnavvlnnlawlYLELKDPRALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAPEAAAI-RYH--LA 878

                         170
                  ....*....|...
gi 1553180212 493 IAQYQAGRFAQAA 505
Cdd:TIGR02917 879 LALLATGRKAEAR 891
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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