2-methylaconitate cis-trans isomerase PrpF family protein similar to PrpF that isomerizes trans-aconitate to cis-aconitate through a base-catalyzed proton abstraction coupled with a rotation about the C2-C3 bond of 2-methylaconitate
PrpF protein; PrpF is a protein found in the 2-methylcitrate pathway. It is structurally ...
5-394
0e+00
PrpF protein; PrpF is a protein found in the 2-methylcitrate pathway. It is structurally similar to DAP epimerase and proline racemase. This protein is likely to acts to isomerize trans-aconitate to cis-aconitate.
The actual alignment was detected with superfamily member TIGR02334:
Pssm-ID: 450302 Cd Length: 390 Bit Score: 688.88 E-value: 0e+00
probable AcnD-accessory protein PrpF; The 2-methylcitrate cycle is one of at least five ...
5-394
0e+00
probable AcnD-accessory protein PrpF; The 2-methylcitrate cycle is one of at least five degradation pathways for propionate via propionyl-CoA. Degradation of propionate toward pyruvate consumes oxaloacetate and releases succinate. Oxidation of succinate back into oxaloacetate by the TCA cycle makes the 2-methylcitrate pathway a cycle. This family consists of PrpF, an incompletely characterized protein that appears to be an essential accessory protein for the Fe/S-dependent 2-methylisocitrate dehydratase AcnD (TIGR02333). This protein is related to but distinct from FldA (part of pfam04303), a putative fluorene degradation protein of Sphingomonas sp. LB126. [Energy metabolism, Fermentation]
Pssm-ID: 131387 Cd Length: 390 Bit Score: 688.88 E-value: 0e+00
PrpF protein; PrpF is a protein found in the 2-methylcitrate pathway. It is structurally ...
6-390
0e+00
PrpF protein; PrpF is a protein found in the 2-methylcitrate pathway. It is structurally similar to DAP epimerase and proline racemase. This protein is likely to acts to isomerize trans-aconitate to cis-aconitate.
Pssm-ID: 398133 Cd Length: 384 Bit Score: 591.83 E-value: 0e+00
probable AcnD-accessory protein PrpF; The 2-methylcitrate cycle is one of at least five ...
5-394
0e+00
probable AcnD-accessory protein PrpF; The 2-methylcitrate cycle is one of at least five degradation pathways for propionate via propionyl-CoA. Degradation of propionate toward pyruvate consumes oxaloacetate and releases succinate. Oxidation of succinate back into oxaloacetate by the TCA cycle makes the 2-methylcitrate pathway a cycle. This family consists of PrpF, an incompletely characterized protein that appears to be an essential accessory protein for the Fe/S-dependent 2-methylisocitrate dehydratase AcnD (TIGR02333). This protein is related to but distinct from FldA (part of pfam04303), a putative fluorene degradation protein of Sphingomonas sp. LB126. [Energy metabolism, Fermentation]
Pssm-ID: 131387 Cd Length: 390 Bit Score: 688.88 E-value: 0e+00
PrpF protein; PrpF is a protein found in the 2-methylcitrate pathway. It is structurally ...
6-390
0e+00
PrpF protein; PrpF is a protein found in the 2-methylcitrate pathway. It is structurally similar to DAP epimerase and proline racemase. This protein is likely to acts to isomerize trans-aconitate to cis-aconitate.
Pssm-ID: 398133 Cd Length: 384 Bit Score: 591.83 E-value: 0e+00
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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