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Conserved domains on  [gi|1575440772|ref|WP_129888639|]
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antibiotic biosynthesis monooxygenase [Ktedonosporobacter rubrisoli]

Protein Classification

antibiotic biosynthesis monooxygenase family protein( domain architecture ID 10006366)

antibiotic biosynthesis monooxygenase family protein may be involved in the biosynthesis of several antibiotics; similar to Streptomyces tetracenomycin-F1 monooxygenase and deoxynogalonate monooxygenase

CATH:  3.30.70.100
EC:  1.-.-.-
Gene Ontology:  GO:0004497|GO:0017000|GO:0016491
PubMed:  31399587
SCOP:  4001439

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 1-96 4.69e-13

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


:

Pssm-ID: 441901  Cd Length: 98  Bit Score: 59.62  E-value: 4.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575440772   1 MIVEYTRYKVQGQQAVALEEAYQRARSGLEQSPHCLSYELSRCLEDQSTFVLRIEWDSVEgHLEGFRKSPEFRAFFEAVK 80
Cdd:COG2329     1 MIVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEE-AFRAWFRSSEHRAAHAKGR 79

                          90
                  ....*....|....*.
gi 1575440772  81 PFFNDIQEMRHYEVTA 96
Cdd:COG2329    80 EILAGPPRVEHYEVVA 95
 
Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 1-96 4.69e-13

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 59.62  E-value: 4.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575440772   1 MIVEYTRYKVQGQQAVALEEAYQRARSGLEQSPHCLSYELSRCLEDQSTFVLRIEWDSVEgHLEGFRKSPEFRAFFEAVK 80
Cdd:COG2329     1 MIVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEE-AFRAWFRSSEHRAAHAKGR 79

                          90
                  ....*....|....*.
gi 1575440772  81 PFFNDIQEMRHYEVTA 96
Cdd:COG2329    80 EILAGPPRVEHYEVVA 95
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 2-75 9.74e-12

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 55.35  E-value: 9.74e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1575440772   2 IVEYTRYKVQGQQAVALEEAYQRARSGLEQSPHCLSYELSRCLEDQSTFVLRIEWDSvEGHLEGFRKSPEFRAF 75
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWED-EAAFEAHLQSPHFKAA 73
 
Name Accession Description Interval E-value
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 1-96 4.69e-13

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 59.62  E-value: 4.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575440772   1 MIVEYTRYKVQGQQAVALEEAYQRARSGLEQSPHCLSYELSRCLEDQSTFVLRIEWDSVEgHLEGFRKSPEFRAFFEAVK 80
Cdd:COG2329     1 MIVVINRFRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEE-AFRAWFRSSEHRAAHAKGR 79

                          90
                  ....*....|....*.
gi 1575440772  81 PFFNDIQEMRHYEVTA 96
Cdd:COG2329    80 EILAGPPRVEHYEVVA 95
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
2-93 1.67e-12

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 58.04  E-value: 1.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575440772   2 IVEYTRYKVQGQQAVALEEAYQRARSGLEQSPHCLSYELSRCLEDQSTFVLRIEWDSVEgHLEGFRKSPEFRAFFEAVKP 81
Cdd:COG1359     1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEA-ALEAHLASPHFKAFLAALAP 79

                          90
                  ....*....|..
gi 1575440772  82 FFNDIQEMRHYE 93
Cdd:COG1359    80 LLAEPPEVRVYE 91
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 2-75 9.74e-12

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 55.35  E-value: 9.74e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1575440772   2 IVEYTRYKVQGQQAVALEEAYQRARSGLEQSPHCLSYELSRCLEDQSTFVLRIEWDSvEGHLEGFRKSPEFRAF 75
Cdd:pfam03992   1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWED-EAAFEAHLQSPHFKAA 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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