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Conserved domains on  [gi|1575743002|ref|WP_130049698|]
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MULTISPECIES: pyruvate dehydrogenase complex transcriptional repressor PdhR [Pseudoalteromonas]

Protein Classification

pyruvate dehydrogenase complex transcriptional repressor PdhR( domain architecture ID 11484191)

pyruvate dehydrogenase complex transcriptional repressor PdhR regulates genes involved in the pyruvate dehydrogenase complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
1-249 2.60e-145

pyruvate dehydrogenase complex transcriptional repressor PdhR;


:

Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 406.33  E-value: 2.60e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   1 MSLKIKAAKLSDVILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQLEEG 80
Cdd:PRK09464    2 AYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  81 LTDPLFDLISKHPESQFDLLEFRHALEGIAAYYAAMRGTTNDFKKVKQSFDNI--ALVNDDLVQKAKAINAFHFSVAEAS 158
Cdd:PRK09464   82 FSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRGTDEDFERIRECHHAIelAQQSGDLDAEANAVMQYQIAVTEAA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002 159 HNVVLLHLVRGMQALLEQNVLQNLTVLLKKPQISQQLAEHRRLLMDAVIEGNPEQARLASNAHLAFIEEALLEAGKEHSR 238
Cdd:PRK09464  162 HNVVLLHLLRCMEPMLEQNVRQNFELLYRRREMLPKVSSHRARIFEAIVAGKPEKAREASHRHLAFIEEILLDLSREESR 241

                         250
                  ....*....|.
gi 1575743002 239 IERSLRRTKQH 249
Cdd:PRK09464  242 RERSLRRLQQR 252
 
Name Accession Description Interval E-value
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
1-249 2.60e-145

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 406.33  E-value: 2.60e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   1 MSLKIKAAKLSDVILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQLEEG 80
Cdd:PRK09464    2 AYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  81 LTDPLFDLISKHPESQFDLLEFRHALEGIAAYYAAMRGTTNDFKKVKQSFDNI--ALVNDDLVQKAKAINAFHFSVAEAS 158
Cdd:PRK09464   82 FSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRGTDEDFERIRECHHAIelAQQSGDLDAEANAVMQYQIAVTEAA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002 159 HNVVLLHLVRGMQALLEQNVLQNLTVLLKKPQISQQLAEHRRLLMDAVIEGNPEQARLASNAHLAFIEEALLEAGKEHSR 238
Cdd:PRK09464  162 HNVVLLHLLRCMEPMLEQNVRQNFELLYRRREMLPKVSSHRARIFEAIVAGKPEKAREASHRHLAFIEEILLDLSREESR 241

                         250
                  ....*....|.
gi 1575743002 239 IERSLRRTKQH 249
Cdd:PRK09464  242 RERSLRRLQQR 252
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-238 2.85e-71

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 217.88  E-value: 2.85e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   4 KIKAAKLSDVILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQLEEGLTD 83
Cdd:COG2186     2 PIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  84 PLFDLISKHPESQFDLLEFRHALEGIAAYYAAMRGTTNDFKKVKQSFDNIALVNDDLVQKAKAINAFHFSVAEASHNVVL 163
Cdd:COG2186    82 PLALLLALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGEAFAEADLAFHRAIAEASGNPLL 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1575743002 164 LHLVRGMQALLEQNVLQNLTVllkKPQISQQLAEHRRLLmDAVIEGNPEQARLASNAHLAFIEEALLEAGKEHSR 238
Cdd:COG2186   162 ALLLESLRELLRRSVRLTLRS---PEARERSLAEHRAIL-DAIRAGDPEAARAAMRAHLEAVRERLREALAERAR 232
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-74 6.54e-26

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 95.98  E-value: 6.54e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1575743002   9 KLSDVILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVK 74
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 10-73 1.80e-24

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 92.29  E-value: 1.80e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1575743002  10 LSDVILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFV 73
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
14-73 8.76e-23

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 88.02  E-value: 8.76e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   14 ILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFV 73
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 14-76 6.60e-12

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 63.26  E-value: 6.60e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1575743002  14 ILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQ 76
Cdd:TIGR02325  13 IADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAAR 75
 
Name Accession Description Interval E-value
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
1-249 2.60e-145

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 406.33  E-value: 2.60e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   1 MSLKIKAAKLSDVILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQLEEG 80
Cdd:PRK09464    2 AYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  81 LTDPLFDLISKHPESQFDLLEFRHALEGIAAYYAAMRGTTNDFKKVKQSFDNI--ALVNDDLVQKAKAINAFHFSVAEAS 158
Cdd:PRK09464   82 FSDPLVELLSDHPESQFDLLETRHALEGIAAYYAALRGTDEDFERIRECHHAIelAQQSGDLDAEANAVMQYQIAVTEAA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002 159 HNVVLLHLVRGMQALLEQNVLQNLTVLLKKPQISQQLAEHRRLLMDAVIEGNPEQARLASNAHLAFIEEALLEAGKEHSR 238
Cdd:PRK09464  162 HNVVLLHLLRCMEPMLEQNVRQNFELLYRRREMLPKVSSHRARIFEAIVAGKPEKAREASHRHLAFIEEILLDLSREESR 241

                         250
                  ....*....|.
gi 1575743002 239 IERSLRRTKQH 249
Cdd:PRK09464  242 RERSLRRLQQR 252
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-238 2.85e-71

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 217.88  E-value: 2.85e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   4 KIKAAKLSDVILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQLEEGLTD 83
Cdd:COG2186     2 PIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  84 PLFDLISKHPESQFDLLEFRHALEGIAAYYAAMRGTTNDFKKVKQSFDNIALVNDDLVQKAKAINAFHFSVAEASHNVVL 163
Cdd:COG2186    82 PLALLLALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGEAFAEADLAFHRAIAEASGNPLL 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1575743002 164 LHLVRGMQALLEQNVLQNLTVllkKPQISQQLAEHRRLLmDAVIEGNPEQARLASNAHLAFIEEALLEAGKEHSR 238
Cdd:COG2186   162 ALLLESLRELLRRSVRLTLRS---PEARERSLAEHRAIL-DAIRAGDPEAARAAMRAHLEAVRERLREALAERAR 232
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 9-244 5.93e-65

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 202.69  E-value: 5.93e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   9 KLSDVILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQ----LEEGLTDP 84
Cdd:PRK10421    2 RLSDEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRhetwSEQNIVQP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  85 LFDLISKHPESQFDLLEFRHALEGIAAYYAAMRGTTNDFKKVKQSFDniALVNDDLVQKAKAINAFHFSVAEASHNVVLL 164
Cdd:PRK10421   82 LKTLMADDPDYSFDILEARHAIEASTAWHAAMRATPGDKEKIQLCFE--ATLSEDPDLASQADVRFHLAIAEASHNVVLL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002 165 HLVRGMQALLEQNVLQNLTVLLKKPQISQQLAEHRRLLMDAVIEGNPEQARLASNAHLAFIEEALLEAGKEHSRIERSLR 244
Cdd:PRK10421  160 QTMRGFFDVLQSSVKQSRQRMYLVPPVFSQLTEQHQAVMDAILAGDAEGARKAMMAHLSFVHTTIKRFDEDQARQARITR 239
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 9-245 1.21e-40

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 139.90  E-value: 1.21e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   9 KLSDVILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQLEEGLTDPLFDL 88
Cdd:PRK09990    7 PIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQDASPLMHL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  89 ISKHPESQFDLLEFRHALEGIAAYYAAMRGTTNDFKKVKQSFDNIALVND-----DLVQKAKAINAFHFSVAEASHNVVL 163
Cdd:PRK09990   87 FSSQPRTLYDLLEVRALLEGESARLAALRGTQADFVLITRRYEEMLAAHEnnkeiDPIEHARLDHAFHLAICEASHNPVL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002 164 LHLVRGMQALLEQNVLQNLTVLLKKPQISQQLAEHRRLLMDAVIEGNPEQARLASNAHLAFIEEALLEAGKEHSRIERSL 243
Cdd:PRK09990  167 VHTLQSLTDLMLSSVFASVNNLYHRPQQKKQIDRQHARLYNAVLQRLPEQAQRAARDHIRTVRDNLREIEQEEQRLVRAT 246


                  ..
gi 1575743002 244 RR 245
Cdd:PRK09990  247 LR 248
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
5-238 7.50e-36

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 126.58  E-value: 7.50e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   5 IKAAKLSDVILQQLENMILEGSLAPGEKLPpERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVknqleegltdP 84
Cdd:COG1802     7 LRRESLAEQVYEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARV----------A 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  85 LFDliskhPESQFDLLEFRHALEGIAAYYAAMRGTTNDFKKVKQSFDNI--ALVNDDLVQKAKAINAFHFSVAEASHNVV 162
Cdd:COG1802    76 PLS-----PEEIRELYEVRAALEGLAARLAAERATPADLARLRALLEELeaAAAAGDVAAYLELDREFHRALVEAAGNPR 150

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1575743002 163 LLHLVRGMQALLEQNVLQNLTVllkKPQISQQLAEHRRLLmDAVIEGNPEQARLASNAHLAFIEEALLEAGKEHSR 238
Cdd:COG1802   151 LAELLRRLRARLRRYRRLSLRS---PGRLEESLAEHRAIL-DALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-74 6.54e-26

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 95.98  E-value: 6.54e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1575743002   9 KLSDVILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVK 74
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK10225 PRK10225
Uxu operon transcriptional regulator;
18-231 2.12e-25

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 100.48  E-value: 2.12e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  18 LENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQLEEGLTDPLfDLISKHPESQF 97
Cdd:PRK10225   18 IRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTDSP-DANVCNDAGPF 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  98 DLLEFRHALEGIAAYYAAMRGTTNDFKKVKQSfdnIALVNDDLVQKAKAINA-----FHFSVAEASHNVVLLHLVRGMQA 172
Cdd:PRK10225   97 ELLQARQLLESNIAEFAALQATREDIVKMRQA---LQLEERELASSAPGSSEsgdmqFHLAIAEATHNSMLVELFRQSWQ 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1575743002 173 LLEQNV--LQNLTVLLKKPQISQQLAEHRRLLMdAVIEGNPEQARLASNAHLAFIEEALLE 231
Cdd:PRK10225  174 WRENNPmwIQLHSHLDDSLYRKEWLGDHKQILA-ALIKKDARAAKLAMWQHLENVKQRLLE 233
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 10-73 1.80e-24

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 92.29  E-value: 1.80e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1575743002  10 LSDVILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFV 73
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 1-222 1.41e-23

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 95.09  E-value: 1.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   1 MSLKIKAAKLSDVILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQLEEG 80
Cdd:PRK03837    5 RSRPIARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  81 LTDPL----FDLISKHPESQFDLLEFRHALEGIAAYYAAMRGTTNDFKKVKQSFDNIALVNDDLVQKAKAINAFHFSVAE 156
Cdd:PRK03837   85 IIGQLsgmaKDFLSQSPDGLAHLKQARLFFESSLARYAAEHATDEQIALLRKALERNSQSLGDNAAFIRSDMEFHRVIAE 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1575743002 157 ASHNVVLLHLVRGM--------QALLEQNVLQNLTvllkkpqisqqLAEHRRLLmDAVIEGNPEQARLASNAHL 222
Cdd:PRK03837  165 IPGNPIFMAIHEALldwliearPEVVILHGHENVT-----------LQEHIAIV-DAIRAHDPDEADRALQSHL 226
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
14-73 8.76e-23

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 88.02  E-value: 8.76e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   14 ILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFV 73
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
14-103 3.70e-22

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 91.08  E-value: 3.70e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  14 ILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQLEEGLTDPLF----DLI 89
Cdd:COG2188    10 IADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTsfteELR 89

                          90
                  ....*....|....
gi 1575743002  90 SKHPESQFDLLEFR 103
Cdd:COG2188    90 ARGREPSTRVLSAE 103
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 98-223 1.84e-17

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 75.86  E-value: 1.84e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   98 DLLEFRHALEGIAAYYAAMRGTTNDFKKVKQSFDNIALV---NDDLVQKAKAINAFHFSVAEASHNVVLLHLVRGMQALL 174
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAaaaGDDLEEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1575743002  175 EQNVLQNLtvllkkPQISQQLAEHRRLLmDAVIEGNPEQARLASNAHLA 223
Cdd:smart00895  81 RRLRRLSL------EAARRALDEHRAIL-DAIRARDAEAARAAMREHLE 122
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 14-84 3.24e-17

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 80.26  E-value: 3.24e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1575743002  14 ILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQLEEGLTDP 84
Cdd:COG1167    17 LADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPAPAP 87
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
14-81 1.66e-13

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 64.81  E-value: 1.66e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1575743002  14 ILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQLEEGL 81
Cdd:COG1725    15 IADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELL 82
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 98-217 5.75e-13

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 63.54  E-value: 5.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  98 DLLEFRHALEGIAAYYAAMRGTTNDFKKVKQSFDNI--ALVNDDLVQKAKAINAFHFSVAEASHNVVLLHLVRGMQALLE 175
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALeaAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1575743002 176 QNVLQNLTVllkkPQISQQLAEHRRLLMDAVIEGNPEQARLA 217
Cdd:pfam07729  81 RLRRLLLSS----PGRLRASLEEHRAILDAIRARDPEAARAA 118
PRK11523 PRK11523
transcriptional regulator ExuR;
17-232 2.07e-12

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 64.87  E-value: 2.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  17 QLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQLEEGLTDPLFDL--ISKHPe 94
Cdd:PRK11523   16 ELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQQAADNNMefANYGP- 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  95 sqFDLLEFRHALEGIAAYYAAMRGTTNDFKKVKQSFDNIAlvNDDLVQKAKAINAFHFSVAEASHNVVLLHLVRGMQALL 174
Cdd:PRK11523   95 --FELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQAR--GEDCFRDSEWDLQFHVQVALATQNSALAAIVEKMWTQR 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1575743002 175 EQN-VLQNLTVLLKKPQISQQLAEHRRLLmDAVIEGNPEQARLASNAHLAFIEEALLEA 232
Cdd:PRK11523  171 SHNpYWKKLHEHIDDRTVDNWCDDHDQIL-KALIRKDPHAAKLAMWQHLENTKQMLFNE 228
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 14-76 6.60e-12

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 63.26  E-value: 6.60e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1575743002  14 ILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQ 76
Cdd:TIGR02325  13 IADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAAR 75
PRK11402 PRK11402
transcriptional regulator PhoB;
16-76 2.95e-11

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 61.39  E-value: 2.95e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1575743002  16 QQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQ 76
Cdd:PRK11402   16 QRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQ 76
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 4-96 2.80e-09

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 56.59  E-value: 2.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   4 KIKAAKLSDvILQQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKNQ-----LE 78
Cdd:PRK15481    1 MITGKTANE-IFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSpspvaLE 79

                          90
                  ....*....|....*....
gi 1575743002  79 EGLTD-PLFDLISKHPESQ 96
Cdd:PRK15481   80 GGDPGtPLHDLAGGNPDPQ 98
PRK09764 PRK09764
GntR family transcriptional regulator;
1-102 3.11e-08

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 52.91  E-value: 3.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002   1 MSLKIKAAKLSDVILQQlenmILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKnqlEEG 80
Cdd:PRK09764    1 MGHKPLYRQIADRIREQ----IARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVK---EER 73

                          90       100
                  ....*....|....*....|....*....
gi 1575743002  81 LTDPLFDLIS-------KHPESQFDLLEF 102
Cdd:PRK09764   74 VNYDIFQLTSfdeklsdRHVDTHSEVLIF 102
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 30-73 6.33e-07

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 49.00  E-value: 6.33e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1575743002  30 GEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFV 73
Cdd:PRK10079   32 GDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLV 75
PRK14999 PRK14999
histidine utilization repressor; Provisional
 16-111 3.80e-06

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 46.85  E-value: 3.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1575743002  16 QQLENMILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVknqleegltdplfdlisKHPES 95
Cdd:PRK14999   19 QDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFV-----------------AEPKG 81

                          90
                  ....*....|....*.
gi 1575743002  96 QFDLLEFRHALEGIAA 111
Cdd:PRK14999   82 QSALFEVRSIAEEIAA 97
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
38-70 6.15e-05

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 41.73  E-value: 6.15e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1575743002  38 ELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGG 70
Cdd:COG1321    29 DIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGG 61
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
22-75 5.69e-04

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 40.24  E-value: 5.69e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1575743002  22 ILEGSLAPGEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGGTFVKN 75
Cdd:PRK04984   20 IWNNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNN 73
HTH_41 pfam14502
Helix-turn-helix domain;
30-73 9.72e-04

Helix-turn-helix domain;


Pssm-ID: 433997 [Multi-domain]  Cd Length: 48  Bit Score: 36.32  E-value: 9.72e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1575743002  30 GEKLPPERELAKQFEVSRPSLREAIQKLEAKGLVT--RRQGGGTFV 73
Cdd:pfam14502   3 GERLPTISEYSHKFELSVGTVQKALKKLEDMKAIQleRRGHNGTYL 48
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
38-70 1.66e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 37.64  E-value: 1.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1575743002  38 ELAKQFEVSRPSLREAIQKLEAKGLVTRRQ----GGG 70
Cdd:COG3355    47 ELAEALDRSRSTVYRSLQKLLEAGLVEREKrnleGGG 83
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 37-70 2.24e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.64  E-value: 2.24e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1575743002  37 RELAKQFEVSRPSLREAIQKLEAKGLVTRRQGGG 70
Cdd:pfam12802  23 AELARRLGISKQTVSRLVKRLEAKGLVEREPSPA 56
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 37-68 2.47e-03

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 35.57  E-value: 2.47e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1575743002  37 RELAKQFEVSRPSLREAIQKLEAKGLVTRRQG 68
Cdd:pfam01978  26 DEIAEESGVPRSKVYEVLRSLEDKGLVEREKG 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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