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Conserved domains on  [gi|1577377125|ref|WP_130148073|]
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MULTISPECIES: roadblock/LC7 domain-containing protein [Acinetobacter]

Protein Classification

roadblock/LC7 domain-containing protein( domain architecture ID 2180)

roadblock/LC7 domain-containing protein similar to Myxococcus xanthus mutual gliding motility protein C (MglC), a component of the polarity control system

CATH:  3.30.450.30
PubMed:  10402468|11084347

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Robl_LC7 super family cl00886
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 6-116 9.76e-04

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


The actual alignment was detected with superfamily member COG2018:

Pssm-ID: 469973  Cd Length: 123  Bit Score: 36.36  E-value: 9.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577377125   6 LDSLLE-IDGFIASALVDSEsGLALAAQGN-NTIDLELAAAGNTEVIRAKRKVARALNLnDSIEDILITLGKQYHLIRPL 83
Cdd:COG2018    10 LDDLVErVPGVRGAVLVSAD-GLLIASSLGlDDDDAERLAAMAAGLLSLARRAARELGA-GEVEQVVVEGERGYLLVTAA 87

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1577377125  84 DSNDALflyLVLDRSKANLAMARHELKHFEKEL 116
Cdd:COG2018    88 GDGAVL---AVLADPDADLGLVRYEMRRLAERL 117
 
Name Accession Description Interval E-value
COG2018 COG2018
Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal ...
 6-116 9.76e-04

Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal transduction mechanisms];


Pssm-ID: 441621  Cd Length: 123  Bit Score: 36.36  E-value: 9.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577377125   6 LDSLLE-IDGFIASALVDSEsGLALAAQGN-NTIDLELAAAGNTEVIRAKRKVARALNLnDSIEDILITLGKQYHLIRPL 83
Cdd:COG2018    10 LDDLVErVPGVRGAVLVSAD-GLLIASSLGlDDDDAERLAAMAAGLLSLARRAARELGA-GEVEQVVVEGERGYLLVTAA 87

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1577377125  84 DSNDALflyLVLDRSKANLAMARHELKHFEKEL 116
Cdd:COG2018    88 GDGAVL---AVLADPDADLGLVRYEMRRLAERL 117
 
Name Accession Description Interval E-value
COG2018 COG2018
Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal ...
 6-116 9.76e-04

Predicted regulator of Ras-like GTPase activity, Roadblock/LC7/MglB family [Signal transduction mechanisms];


Pssm-ID: 441621  Cd Length: 123  Bit Score: 36.36  E-value: 9.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1577377125   6 LDSLLE-IDGFIASALVDSEsGLALAAQGN-NTIDLELAAAGNTEVIRAKRKVARALNLnDSIEDILITLGKQYHLIRPL 83
Cdd:COG2018    10 LDDLVErVPGVRGAVLVSAD-GLLIASSLGlDDDDAERLAAMAAGLLSLARRAARELGA-GEVEQVVVEGERGYLLVTAA 87

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1577377125  84 DSNDALflyLVLDRSKANLAMARHELKHFEKEL 116
Cdd:COG2018    88 GDGAVL---AVLADPDADLGLVRYEMRRLAERL 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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