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Conserved domains on  [gi|1583848115|ref|WP_130663919|]
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PAN domain-containing protein [Rhizobium ruizarguesonis]

Protein Classification

PAN/Apple domain-containing protein; alpha-2-macroglobulin family protein( domain architecture ID 10440150)

PAN/Apple domain-containing protein contains a conserved core of three disulphide bridges and may mediate protein-protein or protein-carbohydrate interactions| alpha-2-macroglobulin family protein with a PAN/APPLE-like domain, with similarity to alpha-2-macroglobulin, a multidomain membrane-anchored pan-peptidase inhibitor that provides protection to the cell by trapping external proteases through a covalent interaction with an activated thioester

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APPLE_Factor_XI_like cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, ...
 135-202 5.97e-15

Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


:

Pssm-ID: 238533  Cd Length: 73  Bit Score: 68.23  E-value: 5.97e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1583848115 135 FALFSNHDVFGNDVDVFSSDTLAECQQACADNAQCSVFTFNAWNKKCFLKAGAGELRLDPRATTGVSS 202
Cdd:cd01100     6 FRQGSNVDFRGGDLSTVFASSAEQCQAACTADPGCLAFTYNTKSKKCFLKSSEGTLTKSTGAVSGPRL 73
PAN_APPLE super family cl00112
PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth ...
 237-266 8.13e-05

PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech anti-platelet proteins. Common structural features include two disulfide bonds that link the alpha-helix to the central region of the protein. PAN domains have significant functional versatility, fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


The actual alignment was detected with superfamily member cd01098:

Pssm-ID: 469620  Cd Length: 84  Bit Score: 40.50  E-value: 8.13e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1583848115 237 SRQQCENICWENDSCVAFSFDTGDRACSMY 266
Cdd:cd01098    33 SLEECREACLSNCSCTAYAYNNGSGGCLLW 62
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 63-94 3.13e-04

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


:

Pssm-ID: 459635  Cd Length: 76  Bit Score: 38.69  E-value: 3.13e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1583848115  63 KSLEDCRKICSERPGCVGFDHTPSSNQCRLFA 94
Cdd:pfam00024  22 SSAEECAQRCTNEPRCRSFTYNPKSKKCHLKS 53
 
Name Accession Description Interval E-value
APPLE_Factor_XI_like cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, ...
 135-202 5.97e-15

Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238533  Cd Length: 73  Bit Score: 68.23  E-value: 5.97e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1583848115 135 FALFSNHDVFGNDVDVFSSDTLAECQQACADNAQCSVFTFNAWNKKCFLKAGAGELRLDPRATTGVSS 202
Cdd:cd01100     6 FRQGSNVDFRGGDLSTVFASSAEQCQAACTADPGCLAFTYNTKSKKCFLKSSEGTLTKSTGAVSGPRL 73
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 134-209 1.79e-07

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 47.55  E-value: 1.79e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1583848115 134 QFALFSNHDVFGNDVDVFSSDTLAECQQACADNAQCSVFTFNAWNKKCFLKAGAGELRldPRAT-TGVSSDLGPPSY 209
Cdd:pfam00024   2 DFERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPRCRSFTYNPKSKKCHLKSSSSGSL--PRLKrSDNKVDYYEKSC 76
APPLE smart00223
APPLE domain; Four-fold repeat in plasma kallikrein and coagulation factor XI. Factor XI apple ...
 137-184 1.68e-05

APPLE domain; Four-fold repeat in plasma kallikrein and coagulation factor XI. Factor XI apple 3 mediates binding to platelets. Factor XI apple 1 binds high-molecular-mass kininogen. Apple 4 in factor XI mediates dimer formation and binds to factor XIIa. Mutations in apple 4 cause factor XI deficiency, an inherited bleeding disorder.


Pssm-ID: 128519  Cd Length: 79  Bit Score: 42.37  E-value: 1.68e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1583848115  137 LFSNHDVFGNDVDVFSSDTLAECQQACADNAQCSVFTFNAWN---KKCFLK 184
Cdd:smart00223   5 IYKNVDFRGSDINTVYVPSAQVCQKRCTSHPRCLFFTFSTNEppeEKCLLK 55
PAN_AP_plant cd01098
Plant PAN/APPLE-like domain; present in plant S-receptor protein kinases and secreted ...
 237-266 8.13e-05

Plant PAN/APPLE-like domain; present in plant S-receptor protein kinases and secreted glycoproteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions. S-receptor protein kinases and S-locus glycoproteins are involved in sporophytic self-incompatibility response in Brassica, one of probably many molecular mechanisms, by which hermaphrodite flowering plants avoid self-fertilization.


Pssm-ID: 238531  Cd Length: 84  Bit Score: 40.50  E-value: 8.13e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1583848115 237 SRQQCENICWENDSCVAFSFDTGDRACSMY 266
Cdd:cd01098    33 SLEECREACLSNCSCTAYAYNNGSGGCLLW 62
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 63-94 3.13e-04

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 38.69  E-value: 3.13e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1583848115  63 KSLEDCRKICSERPGCVGFDHTPSSNQCRLFA 94
Cdd:pfam00024  22 SSAEECAQRCTNEPRCRSFTYNPKSKKCHLKS 53
 
Name Accession Description Interval E-value
APPLE_Factor_XI_like cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, ...
 135-202 5.97e-15

Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238533  Cd Length: 73  Bit Score: 68.23  E-value: 5.97e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1583848115 135 FALFSNHDVFGNDVDVFSSDTLAECQQACADNAQCSVFTFNAWNKKCFLKAGAGELRLDPRATTGVSS 202
Cdd:cd01100     6 FRQGSNVDFRGGDLSTVFASSAEQCQAACTADPGCLAFTYNTKSKKCFLKSSEGTLTKSTGAVSGPRL 73
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 134-209 1.79e-07

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 47.55  E-value: 1.79e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1583848115 134 QFALFSNHDVFGNDVDVFSSDTLAECQQACADNAQCSVFTFNAWNKKCFLKAGAGELRldPRAT-TGVSSDLGPPSY 209
Cdd:pfam00024   2 DFERVPGSSLSGVDVSTVTVSSAEECAQRCTNEPRCRSFTYNPKSKKCHLKSSSSGSL--PRLKrSDNKVDYYEKSC 76
APPLE smart00223
APPLE domain; Four-fold repeat in plasma kallikrein and coagulation factor XI. Factor XI apple ...
 137-184 1.68e-05

APPLE domain; Four-fold repeat in plasma kallikrein and coagulation factor XI. Factor XI apple 3 mediates binding to platelets. Factor XI apple 1 binds high-molecular-mass kininogen. Apple 4 in factor XI mediates dimer formation and binds to factor XIIa. Mutations in apple 4 cause factor XI deficiency, an inherited bleeding disorder.


Pssm-ID: 128519  Cd Length: 79  Bit Score: 42.37  E-value: 1.68e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1583848115  137 LFSNHDVFGNDVDVFSSDTLAECQQACADNAQCSVFTFNAWN---KKCFLK 184
Cdd:smart00223   5 IYKNVDFRGSDINTVYVPSAQVCQKRCTSHPRCLFFTFSTNEppeEKCLLK 55
PAN_AP_plant cd01098
Plant PAN/APPLE-like domain; present in plant S-receptor protein kinases and secreted ...
 134-186 2.48e-05

Plant PAN/APPLE-like domain; present in plant S-receptor protein kinases and secreted glycoproteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions. S-receptor protein kinases and S-locus glycoproteins are involved in sporophytic self-incompatibility response in Brassica, one of probably many molecular mechanisms, by which hermaphrodite flowering plants avoid self-fertilization.


Pssm-ID: 238531  Cd Length: 84  Bit Score: 42.04  E-value: 2.48e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1583848115 134 QFALFSNHDVFGNDVdVFSSDTLAECQQACADNAQCSVFTFNAWNKKCFLKAG 186
Cdd:cd01098    13 GFLKLPDVKLPDNAS-AITAISLEECREACLSNCSCTAYAYNNGSGGCLLWNG 64
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
 134-201 2.66e-05

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 41.80  E-value: 2.66e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1583848115  134 QFALFSNHDVFGNDVDVFSSDTLAECQQACADNA-QCSVFTFNAWNKKCFLKAGAGELRLDPRATTGVS 201
Cdd:smart00473   5 CFVRLPNTKLPGFSRIVISVASLEECASKCLNSNcSCRSFTYNNGTKGCLLWSESSLGDARLFPSGGVD 73
PAN_AP_plant cd01098
Plant PAN/APPLE-like domain; present in plant S-receptor protein kinases and secreted ...
 237-266 8.13e-05

Plant PAN/APPLE-like domain; present in plant S-receptor protein kinases and secreted glycoproteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions. S-receptor protein kinases and S-locus glycoproteins are involved in sporophytic self-incompatibility response in Brassica, one of probably many molecular mechanisms, by which hermaphrodite flowering plants avoid self-fertilization.


Pssm-ID: 238531  Cd Length: 84  Bit Score: 40.50  E-value: 8.13e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1583848115 237 SRQQCENICWENDSCVAFSFDTGDRACSMY 266
Cdd:cd01098    33 SLEECREACLSNCSCTAYAYNNGSGGCLLW 62
PAN_4 pfam14295
PAN domain;
141-184 8.34e-05

PAN domain;


Pssm-ID: 433846  Cd Length: 51  Bit Score: 39.31  E-value: 8.34e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1583848115 141 HDVFGNDVDVF--SSDTLAECQQACADNAQCSVFTFNAWNKK-----CFLK 184
Cdd:pfam14295   1 TDRPGGDYRNGelLVDSPEACCAACDADPRCNAWTFVKPGYQgsyarCWLK 51
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
 63-94 3.13e-04

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 38.69  E-value: 3.13e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1583848115  63 KSLEDCRKICSERPGCVGFDHTPSSNQCRLFA 94
Cdd:pfam00024  22 SSAEECAQRCTNEPRCRSFTYNPKSKKCHLKS 53
APPLE_Factor_XI_like cd01100
Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, ...
 239-284 4.51e-03

Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238533  Cd Length: 73  Bit Score: 35.10  E-value: 4.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1583848115 239 QQCENICWENDSCVAFSFDTGDRACSMYERADNRFPGQGIESGSKV 284
Cdd:cd01100    28 EQCQAACTADPGCLAFTYNTKSKKCFLKSSEGTLTKSTGAVSGPRL 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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