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Conserved domains on  [gi|1584003447|ref|WP_130773690|]
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LuxR family transcriptional regulator [Rhizobium ruizarguesonis]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 10507064)

helix-turn-helix (HTH) transcriptional regulator containing an N-terminal an autoinducer binding domain and a LuxR family HTH DNA-binding domain; may act as an activator or repressor in response to an inducer

Gene Ontology:  GO:0006355|GO:0003677|GO:0003700
PubMed:  15808743|19076237|10473770|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Autoind_bind pfam03472
Autoinducer binding domain; This domain is found a a large family of transcriptional ...
 24-165 4.98e-28

Autoinducer binding domain; This domain is found a a large family of transcriptional regulators. This domain specifically binds to autoinducer molecules (N-Acyl homoserine lactones, chlorolactone and rosmarinic acid) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 427319  Cd Length: 148  Bit Score: 104.37  E-value: 4.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447  24 SKDDVLLLLGKISQYFGFSYFAISGIPSPPERIDPYFVLGNWSAGWFDRYRENNYVHADPIVQFSKTCDHAFVWSEALRD 103
Cdd:pfam03472   1 SEEELFDALARLAAALGFDHFAYGARAPLGLSAPDVLVLSNYPAEWLDRYDEANYFAIDPVVRHARRSSSPFSWSDVLFA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1584003447 104 QKLARQsRRVMNEAREFKLIDGFSVPFHTAAGFQSIVSFGAERVELS----TCDRSALYLMATYAH 165
Cdd:pfam03472  81 EARGAE-RRFLDEARDFGLRDGYTVPVHGPGGRLGALSFAGPGEDLDpaeaIEAAARLQLLAIYAH 145
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 187-242 9.68e-18

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


:

Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 74.49  E-value: 9.68e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1584003447 187 TTREREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIAESFR 242
Cdd:cd06170     2 TPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
 
Name Accession Description Interval E-value
Autoind_bind pfam03472
Autoinducer binding domain; This domain is found a a large family of transcriptional ...
 24-165 4.98e-28

Autoinducer binding domain; This domain is found a a large family of transcriptional regulators. This domain specifically binds to autoinducer molecules (N-Acyl homoserine lactones, chlorolactone and rosmarinic acid) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 427319  Cd Length: 148  Bit Score: 104.37  E-value: 4.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447  24 SKDDVLLLLGKISQYFGFSYFAISGIPSPPERIDPYFVLGNWSAGWFDRYRENNYVHADPIVQFSKTCDHAFVWSEALRD 103
Cdd:pfam03472   1 SEEELFDALARLAAALGFDHFAYGARAPLGLSAPDVLVLSNYPAEWLDRYDEANYFAIDPVVRHARRSSSPFSWSDVLFA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1584003447 104 QKLARQsRRVMNEAREFKLIDGFSVPFHTAAGFQSIVSFGAERVELS----TCDRSALYLMATYAH 165
Cdd:pfam03472  81 EARGAE-RRFLDEARDFGLRDGYTVPVHGPGGRLGALSFAGPGEDLDpaeaIEAAARLQLLAIYAH 145
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 187-242 9.68e-18

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 74.49  E-value: 9.68e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1584003447 187 TTREREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIAESFR 242
Cdd:cd06170     2 TPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 183-238 9.41e-16

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 69.09  E-value: 9.41e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1584003447  183 LPMITTREREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIA 238
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVR 56
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
59-246 5.82e-15

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 70.94  E-value: 5.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447  59 YFVLGNWSAGWFDRYRENNYVHADPIVQFSKTCDHAFVWSEALRDQKLARQSRRVMNEAREFKLIDGFSVPFHTAAGFQS 138
Cdd:COG2771     1 LLLLALALLLLALLLLLLALLALLLLLLLAALLLLLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447 139 IVSFGAERVELSTCDRSALYLMATYAHSLLRAQIGNDASRKIQALPMITTREREIIHWCAAGKTAIEIATILGRSHRTIQ 218
Cdd:COG2771    81 LLALLLLLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVR 160

                         170       180
                  ....*....|....*....|....*...
gi 1584003447 219 NVILNIQRKLNVVNTPQMIAESFRLRII 246
Cdd:COG2771   161 THLKRIYRKLGVSSRAELVALALRLGLI 188
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 179-246 2.32e-13

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 63.44  E-value: 2.32e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1584003447 179 KIQALPMITTREREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIAESFRLRII 246
Cdd:COG5905     6 STSHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLL 73
PRK13870 PRK13870
transcriptional regulator TraR; Provisional
 32-246 1.33e-12

transcriptional regulator TraR; Provisional


Pssm-ID: 172390 [Multi-domain]  Cd Length: 234  Bit Score: 65.01  E-value: 1.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447  32 LGKISQYFGFSYFAISGIPSpperiDPYFVLGNWSAGWFDRYRENNYVHADPIVQFSKTCDHAFVWSEALRDQKLARQSR 111
Cdd:PRK13870   25 LADIADHFGFTGYAYLHIQH-----RHITAVTNYHREWQSVYFDKKFDALDPVVKRARSRKHIFTWSGEQERPRLSKDER 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447 112 RVMNEAREFKLIDGFSVPFHTAAGFQSIVSFGAERVELSTcDRSALYLMATYAHSLLRAQIGN-DASRKIQALPMITTRE 190
Cdd:PRK13870  100 AFYAHAADFGIRSGITIPIKTANGSMSMFTLASEKPVIDL-DREIDAVAAAATIGQIHARISFlRTTPTAEDAAWLDPKE 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1584003447 191 REIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIAESFRLRII 246
Cdd:PRK13870  179 ATYLRWIAVGKTMEEIADVEGVKYNSVRVKLREAMKRFDVRSKAHLTALAIRRKLI 234
GerE pfam00196
Bacterial regulatory proteins, luxR family;
187-237 3.98e-10

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 54.13  E-value: 3.98e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1584003447 187 TTREREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMI 237
Cdd:pfam00196   4 SPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELV 54
PRK15369 PRK15369
two component system response regulator;
184-246 1.10e-05

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 45.07  E-value: 1.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1584003447 184 PMITTREREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIAESFRLRII 246
Cdd:PRK15369  148 PLLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARRLGLI 210
 
Name Accession Description Interval E-value
Autoind_bind pfam03472
Autoinducer binding domain; This domain is found a a large family of transcriptional ...
 24-165 4.98e-28

Autoinducer binding domain; This domain is found a a large family of transcriptional regulators. This domain specifically binds to autoinducer molecules (N-Acyl homoserine lactones, chlorolactone and rosmarinic acid) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 427319  Cd Length: 148  Bit Score: 104.37  E-value: 4.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447  24 SKDDVLLLLGKISQYFGFSYFAISGIPSPPERIDPYFVLGNWSAGWFDRYRENNYVHADPIVQFSKTCDHAFVWSEALRD 103
Cdd:pfam03472   1 SEEELFDALARLAAALGFDHFAYGARAPLGLSAPDVLVLSNYPAEWLDRYDEANYFAIDPVVRHARRSSSPFSWSDVLFA 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1584003447 104 QKLARQsRRVMNEAREFKLIDGFSVPFHTAAGFQSIVSFGAERVELS----TCDRSALYLMATYAH 165
Cdd:pfam03472  81 EARGAE-RRFLDEARDFGLRDGYTVPVHGPGGRLGALSFAGPGEDLDpaeaIEAAARLQLLAIYAH 145
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 187-242 9.68e-18

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 74.49  E-value: 9.68e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1584003447 187 TTREREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIAESFR 242
Cdd:cd06170     2 TPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 183-238 9.41e-16

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 69.09  E-value: 9.41e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1584003447  183 LPMITTREREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIA 238
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVR 56
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
59-246 5.82e-15

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 70.94  E-value: 5.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447  59 YFVLGNWSAGWFDRYRENNYVHADPIVQFSKTCDHAFVWSEALRDQKLARQSRRVMNEAREFKLIDGFSVPFHTAAGFQS 138
Cdd:COG2771     1 LLLLALALLLLALLLLLLALLALLLLLLLAALLLLLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447 139 IVSFGAERVELSTCDRSALYLMATYAHSLLRAQIGNDASRKIQALPMITTREREIIHWCAAGKTAIEIATILGRSHRTIQ 218
Cdd:COG2771    81 LLALLLLLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVR 160

                         170       180
                  ....*....|....*....|....*...
gi 1584003447 219 NVILNIQRKLNVVNTPQMIAESFRLRII 246
Cdd:COG2771   161 THLKRIYRKLGVSSRAELVALALRLGLI 188
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 179-246 2.32e-13

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 63.44  E-value: 2.32e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1584003447 179 KIQALPMITTREREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIAESFRLRII 246
Cdd:COG5905     6 STSHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLL 73
PRK13870 PRK13870
transcriptional regulator TraR; Provisional
 32-246 1.33e-12

transcriptional regulator TraR; Provisional


Pssm-ID: 172390 [Multi-domain]  Cd Length: 234  Bit Score: 65.01  E-value: 1.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447  32 LGKISQYFGFSYFAISGIPSpperiDPYFVLGNWSAGWFDRYRENNYVHADPIVQFSKTCDHAFVWSEALRDQKLARQSR 111
Cdd:PRK13870   25 LADIADHFGFTGYAYLHIQH-----RHITAVTNYHREWQSVYFDKKFDALDPVVKRARSRKHIFTWSGEQERPRLSKDER 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447 112 RVMNEAREFKLIDGFSVPFHTAAGFQSIVSFGAERVELSTcDRSALYLMATYAHSLLRAQIGN-DASRKIQALPMITTRE 190
Cdd:PRK13870  100 AFYAHAADFGIRSGITIPIKTANGSMSMFTLASEKPVIDL-DREIDAVAAAATIGQIHARISFlRTTPTAEDAAWLDPKE 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1584003447 191 REIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIAESFRLRII 246
Cdd:PRK13870  179 ATYLRWIAVGKTMEEIADVEGVKYNSVRVKLREAMKRFDVRSKAHLTALAIRRKLI 234
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 173-247 8.27e-12

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 60.68  E-value: 8.27e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1584003447 173 GNDASRKIqalpmITTREREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIAESFRLRIIR 247
Cdd:COG2197    62 GLEALRRL-----LTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
GerE pfam00196
Bacterial regulatory proteins, luxR family;
187-237 3.98e-10

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 54.13  E-value: 3.98e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1584003447 187 TTREREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMI 237
Cdd:pfam00196   4 SPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELV 54
PRK10188 PRK10188
transcriptional regulator SdiA;
24-236 5.80e-10

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 57.87  E-value: 5.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447  24 SKDDVLLLLGKISQYFGFSYFAI---SGIPSPPERIDPYfvlGNWSAGWFDRYRENNYVHADPIVQFSKTCDHAFVWSEA 100
Cdd:PRK10188   22 AAEEVYHELQLQTQQLEYDYYSLcvrHPVPFTRPKVAFY---TTYPEAWVSHYQAENYFAIDPVLKPENFSQGHLMWNDD 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447 101 LrdqklARQSRRVMNEAREFKLIDGFS----VPFHtAAGFQSiVSFGAERVELSTCDRSALYLMATYAHSLLRAQIGNDa 176
Cdd:PRK10188   99 L-----FSEAQALWDAARAHGLRRGVTqclmLPNR-ALGFLS-FSRCSAREIPILSDELELRLQLLVRESLMALMRLED- 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1584003447 177 srkiqalPMITT-------REREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQM 236
Cdd:PRK10188  171 -------EMVMTpemnfskREKEILKWTAEGKTSAEIAMILSISENTVNFHQKNMQKKFNAPNKTQI 230
PRK15369 PRK15369
two component system response regulator;
184-246 1.10e-05

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 45.07  E-value: 1.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1584003447 184 PMITTREREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIAESFRLRII 246
Cdd:PRK15369  148 PLLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARRLGLI 210
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 160-244 7.78e-05

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 42.39  E-value: 7.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447 160 MATYAHSLLRAQIGNDASRKIQALpmiTTREREIIHWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIAE 239
Cdd:COG4566   115 LARDRARRAERARRAELRARLASL---TPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARSLAELVRL 191


                  ....*
gi 1584003447 240 SFRLR 244
Cdd:COG4566   192 ALALG 196
Tra8 COG2826
Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];
186-221 2.91e-04

Transposase and inactivated derivatives, IS30 family [Mobilome: prophages, transposons];


Pssm-ID: 442074 [Multi-domain]  Cd Length: 325  Bit Score: 41.40  E-value: 2.91e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1584003447 186 ITTREREII-HWCAAGKTAIEIATILGRSHRTIQNVI 221
Cdd:COG2826     7 LTLEEREEIeALLKAGLSVREIARRLGRSPSTISREL 43
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
164-247 6.20e-04

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 39.69  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584003447 164 AHSLLRAQIGNDASRKIQALPMITTRereiihWCAAGKTAIEIATILGRSHRTIQNVILNIQRKLNVVNTPQMIAESFRL 243
Cdd:COG2909   107 GRLLLRALALRALGDREEALAALRRR------LLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARAREL 180


                  ....
gi 1584003447 244 RIIR 247
Cdd:COG2909   181 GLLA 184
HTH_38 pfam13936
Helix-turn-helix domain; This helix-turn-helix domain is often found in transferases and is ...
 190-221 1.02e-03

Helix-turn-helix domain; This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.


Pssm-ID: 433591 [Multi-domain]  Cd Length: 44  Bit Score: 35.95  E-value: 1.02e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1584003447 190 EREIIH-WCAAGKTAIEIATILGRSHRTIQNVI 221
Cdd:pfam13936   9 EREEIArLLAEGLSLREIARRLGRSPSTISREL 41
HTH_23 pfam13384
Homeodomain-like domain;
185-221 8.40e-03

Homeodomain-like domain;


Pssm-ID: 433164 [Multi-domain]  Cd Length: 50  Bit Score: 33.78  E-value: 8.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1584003447 185 MITTRER-EIIHWCAAGKTAIEIATILGRSHRTIQNVI 221
Cdd:pfam13384   1 SARERRRaRALLLLAEGLSVKEIAELLGVSRRTVYRWL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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