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Conserved domains on  [gi|1584007151|ref|WP_130777041|]
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MULTISPECIES: ROK family protein [Bacillus]

Protein Classification

ROK family transcriptional regulator( domain architecture ID 11973053)

NagC/ROK (Repressor, ORF, Kinase) family transcriptional regulator is involved in carbohydrate-dependent transcriptional control; contains a DNA-binding helix-turn-helix (HTH) domain

CATH:  3.30.420.40|1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0005524|GO:0003677
PubMed:  20512568|17979299|7952186|15808743|2644244|8831795|7781919|8800467
SCOP:  3000034|3000092|4000330

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 78-321 1.24e-27

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


:

Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 109.60  E-value: 1.24e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151  78 NPEYMLGLAIFLEKNETNYTIFNCLGEVKEQGSTSSMLIDTG---VNVLSKHIERLIA----TFPKISSISIGVPGSVD- 149
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGPeavLEAIAELIEELLAeagiSRGRILGIGIGVPGPVDp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 150 -NGRIFYIPGYEKFQNFNLKSHLEEQFSIPVVIENDMNAAVLG-YYKNTGNyDNSSLVYLYSGqNGPGAGIMVNGDVVRG 227
Cdd:COG1940    81 eTGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAeAWFGAGR-GADNVVYLTLG-TGIGGGIVINGKLLRG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 228 STFFSGEISFVP---------------------------QYNNKNFLQALRSED------SNNP------EEYnIDAITR 268
Cdd:COG1940   159 ANGNAGEIGHMPvdpdgplcgcgnrgcletyasgpallrRARELGGAEKLTAEElfaaarAGDPlalevlDEA-ARYLGI 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1584007151 269 LIATCIAIINPHAFIFCDD--EVNQFVIEQIVKSCPQYI--PAEHIPKITVSNWKED 321
Cdd:COG1940   238 GLANLINLLDPEVIVLGGGvsAAGDLLLEPIREALAKYAlpPAREDPRIVPASLGDD 294
COG3398 super family cl28563
Predicted transcriptional regulator, contains two HTH domains [Transcription];
17-82 5.75e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


The actual alignment was detected with superfamily member COG3398:

Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 39.86  E-value: 5.75e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1584007151  17 RGIRKVLLERGSATKVELSNTLEISFPTISKFIEKMKQDGEVtlagldDSSGGRRAKRYEYNPEYM 82
Cdd:COG3398   100 RRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLV------ERERDGRNVRYYLNPPER 159
 
Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 78-321 1.24e-27

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 109.60  E-value: 1.24e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151  78 NPEYMLGLAIFLEKNETNYTIFNCLGEVKEQGSTSSMLIDTG---VNVLSKHIERLIA----TFPKISSISIGVPGSVD- 149
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGPeavLEAIAELIEELLAeagiSRGRILGIGIGVPGPVDp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 150 -NGRIFYIPGYEKFQNFNLKSHLEEQFSIPVVIENDMNAAVLG-YYKNTGNyDNSSLVYLYSGqNGPGAGIMVNGDVVRG 227
Cdd:COG1940    81 eTGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAeAWFGAGR-GADNVVYLTLG-TGIGGGIVINGKLLRG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 228 STFFSGEISFVP---------------------------QYNNKNFLQALRSED------SNNP------EEYnIDAITR 268
Cdd:COG1940   159 ANGNAGEIGHMPvdpdgplcgcgnrgcletyasgpallrRARELGGAEKLTAEElfaaarAGDPlalevlDEA-ARYLGI 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1584007151 269 LIATCIAIINPHAFIFCDD--EVNQFVIEQIVKSCPQYI--PAEHIPKITVSNWKED 321
Cdd:COG1940   238 GLANLINLLDPEVIVLGGGvsAAGDLLLEPIREALAKYAlpPAREDPRIVPASLGDD 294
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 117-284 9.37e-25

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 100.23  E-value: 9.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 117 DTGVNVLSKHIERLIATFP---KISSISIGVPGSVD--NGRIFYIPGYEKFQNFNLKSHLEEQFSIPVVIENDMNAAVLG 191
Cdd:cd23763    36 EAVLDRIAELIEELLAEAGvreRILGIGIGVPGPVDpeTGIVLFAPNLPWWKNVPLRELLEERLGLPVVVENDANAAALG 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 192 -YYKNTG-NYDNssLVYLYSGqNGPGAGIMVNGDVVRGSTFFSGEISFVPQYnnknflqalrsedsnnpEEYnIDAITRL 269
Cdd:cd23763   116 eAWFGAGrGVRN--FVYITLG-TGIGGGIIIDGKLYRGANGAAGEIGHITVL-----------------EEA-ARYLGIG 174

                         170
                  ....*....|....*
gi 1584007151 270 IATCIAIINPHAFIF 284
Cdd:cd23763   175 LANLINLLNPELIVL 189
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 117-284 4.91e-18

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 82.77  E-value: 4.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 117 DTGVNVLSKHIERLIATFPKISSISIGVPGSVDNGR--IFYIP--GYEkfqNFNLKSHLEEQFSIPVVIENDMNAAVLGY 192
Cdd:pfam00480  36 ETLVDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYgyITNTPniGWD---NFDLVEKLEERFNVPVFFENDANAAALAE 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 193 YKNTGNYDNSSLVYLYSGqNGPGAGIMVNGDVVRGSTFFSGEISFVP--------------------------------- 239
Cdd:pfam00480 113 AVFGASKDVQNVIYVTVG-TGVGGGVISNGKLFTGRNGVAGEIGHIQldpngpkcgcgnhgcletiasgralekryqqkg 191

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1584007151 240 -QYNNKNFLQALRSEDSNNPEEYNI--DAITRLIATCIAIINPHAFIF 284
Cdd:pfam00480 192 eDLEGKDIIVLAEQGDEVAEEAVERlaRYLAKAIANLINLFDPQAIVL 239
PRK09698 PRK09698
D-allose kinase; Provisional
 108-283 1.52e-08

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 55.37  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 108 QGSTSSMLIDtgvnVLSKHIERLIATfpkISSISIGVPGSVDNGR--IFYIPGYEKF--QNFNLKSHLEEQFSIPVVIEN 183
Cdd:PRK09698   40 APDLVSGLGE----MIDEYLRRFNAR---CHGIVMGFPALVSKDRrtVISTPNLPLTalDLYDLADKLENTLNCPVFFSR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 184 DMNAAVLgYYKNTGNYDNSSLVYLYSGqNGPGAGIMVNGDVVRGSTFFSGEISFVPQYN--------NKNFLQ------A 249
Cdd:PRK09698  113 DVNLQLL-WDVKENNLTQQLVLGAYLG-TGMGFAVWMNGAPWTGAHGVAGELGHIPLGDmtqhcgcgNPGCLEtncsgmA 190

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1584007151 250 LRSEDSNNPEEYNIDAI-----------------TRLIATCIAIINPHAFI 283
Cdd:PRK09698  191 LRRWYEQQPRDYPLSDLfvhagdhpfiqsllenlARAIATSINLFDPDAII 241
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
17-82 5.75e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 39.86  E-value: 5.75e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1584007151  17 RGIRKVLLERGSATKVELSNTLEISFPTISKFIEKMKQDGEVtlagldDSSGGRRAKRYEYNPEYM 82
Cdd:COG3398   100 RRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLV------ERERDGRNVRYYLNPPER 159
 
Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 78-321 1.24e-27

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 109.60  E-value: 1.24e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151  78 NPEYMLGLAIFLEKNETNYTIFNCLGEVKEQGSTSSMLIDTG---VNVLSKHIERLIA----TFPKISSISIGVPGSVD- 149
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGAGPeavLEAIAELIEELLAeagiSRGRILGIGIGVPGPVDp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 150 -NGRIFYIPGYEKFQNFNLKSHLEEQFSIPVVIENDMNAAVLG-YYKNTGNyDNSSLVYLYSGqNGPGAGIMVNGDVVRG 227
Cdd:COG1940    81 eTGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAeAWFGAGR-GADNVVYLTLG-TGIGGGIVINGKLLRG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 228 STFFSGEISFVP---------------------------QYNNKNFLQALRSED------SNNP------EEYnIDAITR 268
Cdd:COG1940   159 ANGNAGEIGHMPvdpdgplcgcgnrgcletyasgpallrRARELGGAEKLTAEElfaaarAGDPlalevlDEA-ARYLGI 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1584007151 269 LIATCIAIINPHAFIFCDD--EVNQFVIEQIVKSCPQYI--PAEHIPKITVSNWKED 321
Cdd:COG1940   238 GLANLINLLDPEVIVLGGGvsAAGDLLLEPIREALAKYAlpPAREDPRIVPASLGDD 294
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 117-284 9.37e-25

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 100.23  E-value: 9.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 117 DTGVNVLSKHIERLIATFP---KISSISIGVPGSVD--NGRIFYIPGYEKFQNFNLKSHLEEQFSIPVVIENDMNAAVLG 191
Cdd:cd23763    36 EAVLDRIAELIEELLAEAGvreRILGIGIGVPGPVDpeTGIVLFAPNLPWWKNVPLRELLEERLGLPVVVENDANAAALG 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 192 -YYKNTG-NYDNssLVYLYSGqNGPGAGIMVNGDVVRGSTFFSGEISFVPQYnnknflqalrsedsnnpEEYnIDAITRL 269
Cdd:cd23763   116 eAWFGAGrGVRN--FVYITLG-TGIGGGIIIDGKLYRGANGAAGEIGHITVL-----------------EEA-ARYLGIG 174

                         170
                  ....*....|....*
gi 1584007151 270 IATCIAIINPHAFIF 284
Cdd:cd23763   175 LANLINLLNPELIVL 189
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 104-235 1.46e-22

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 95.73  E-value: 1.46e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 104 EVKEQGSTSSMLidtgvNVLSKHIERLI---ATFPKISSISIGVPGSVD--NGRIFYIPGYEKFQNFNLKSHLEEQFSIP 178
Cdd:cd24059    31 PLDEKENPEEVL-----EKLYELIDRLLekeNIKSKILGIGIGAPGPLDveKGIILNPPNFPGWENIPLVELLEEKFGIP 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1584007151 179 VVIENDMNAAVLG--YYKNTGNYDNssLVYLYSGqNGPGAGIMVNGDVVRGSTFFSGEI 235
Cdd:cd24059   106 VYLDNDANAAALAekWYGKGKNYDN--FIYILAD-EGIGAGIIINGKLYRGVDGYAGEI 161
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 81-235 8.01e-21

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 91.09  E-value: 8.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151  81 YMLGLAIflEKNETNYTIFNCLGEV---KEQGSTSSMLIDTGVNVLSKHIERLIATFP----KISSISIGVPGSVD--NG 151
Cdd:cd24076     2 AVIGVEL--GVDYITVVVTDLAGEVlwrREVPLPASDDPDEVLAQLAALIREALAAAPdsplGILGIGVGVPGLVDseDG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 152 RIFYIP--GYekfQNFNLKSHLEEQFSIPVVIENDMNAAVLG--YYKNTGNYDNssLVYLYSGqNGPGAGIMVNGDVVRG 227
Cdd:cd24076    80 VVLLAPnlGW---RDVPLRDLLEEALGVPVFVDNEANAAALAekRFGAGRGVSD--LVYLSAG-VGIGAGIILDGELYRG 153


                  ....*...
gi 1584007151 228 STFFSGEI 235
Cdd:cd24076   154 ASGFAGEI 161
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 102-284 6.14e-19

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 85.68  E-value: 6.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 102 LGEVKEQGSTSSMLI---------DTGVNVLSKHIERLIATFP-KISSISIGVPGSVDNGR--IFYIPGYEKFQNFNLKS 169
Cdd:cd24070    15 IGLVDEDGKLLDFEKvpskdllraGDPVEVLADLIREYIEEAGlKPAAIVIGVPGTVDKDRrtVISTPNIPGLDGVNLAD 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 170 HLEEQFSIPVVIENDMNAAVLGYYKNTGNYDNSSLVYLYSGqNGPGAGIMVNGDVVRGSTFFSGEISFVPQYNNKN---- 245
Cdd:cd24070    95 ILENKLGIPVILERDVNLLLLYDMRAGNLDDEGVVLGFYIG-TGIGNAILINGKPLRGKNGVAGELGHIPVYGNGKpcgc 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1584007151 246 -------------FLQALRSE---DSNNPEEYN-----------IDAITRLIATCIAIINPHAFIF 284
Cdd:cd24070   174 gntgcletyasgrALEEIAEEhypDTPILDIFVdhgdepeldefVEDLALAIATEINILDPDAVIL 239
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 94-243 8.89e-19

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 84.93  E-value: 8.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151  94 TNYTIFNCLGEVKEQGSTSSmlIDTGVNVLSKHIERLIATF-PKISSISIGVPGSVD--NGRIFYIPGYEKFQNFNLKSH 170
Cdd:cd24152    12 IKYALVDENGNIIKKGKIPT--PKDSLEEFLDYIKKIIKRYdEEIDGIAISAPGVIDpeTGIIYGGGALPYLKGFNLKEE 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1584007151 171 LEEQFSIPVVIENDMNAAVLG--YYKNTGNYDNSSLVYLYSGQngpGAGIMVNGDVVRGSTFFSGEISFVPQYNN 243
Cdd:cd24152    90 LEERCNLPVSIENDAKCAALAelWLGSLKGIKNGAVIVLGTGI---GGAIIIDGKLYRGSHFFAGEFSYLLTDDD 161
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 117-284 4.91e-18

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 82.77  E-value: 4.91e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 117 DTGVNVLSKHIERLIATFPKISSISIGVPGSVDNGR--IFYIP--GYEkfqNFNLKSHLEEQFSIPVVIENDMNAAVLGY 192
Cdd:pfam00480  36 ETLVDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYgyITNTPniGWD---NFDLVEKLEERFNVPVFFENDANAAALAE 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 193 YKNTGNYDNSSLVYLYSGqNGPGAGIMVNGDVVRGSTFFSGEISFVP--------------------------------- 239
Cdd:pfam00480 113 AVFGASKDVQNVIYVTVG-TGVGGGVISNGKLFTGRNGVAGEIGHIQldpngpkcgcgnhgcletiasgralekryqqkg 191

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1584007151 240 -QYNNKNFLQALRSEDSNNPEEYNI--DAITRLIATCIAIINPHAFIF 284
Cdd:pfam00480 192 eDLEGKDIIVLAEQGDEVAEEAVERlaRYLAKAIANLINLFDPQAIVL 239
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 123-235 2.11e-17

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 81.06  E-value: 2.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 123 LSKHIERLIATfPKISSISIGVPGSVD--NGRIFY----IPGYekfQNFNLKSHLEEQFSIPVVIENDMNAAVLG-YYKN 195
Cdd:cd24068    44 LLEIIAELKEK-YDIEGIGISSAGQVDpkTGEVIYatdnLPGW---TGTNLKEELEERFGLPVAVENDVNCAALAeKWLG 119

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1584007151 196 TGNyDNSSLVYLYSGqNGPGAGIMVNGDVVRGSTFFSGEI 235
Cdd:cd24068   120 AAK-GLDDFLCLTLG-TGIGGAIILDGRLYRGANGSAGEL 157
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 116-235 4.90e-17

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 80.28  E-value: 4.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 116 IDTGVNVLSKHIERLIATFPK----ISSISIGVPGSVDNGRIFYIPgYEKFQNFNLKSHLEEQFSIPVVIENDMNAAVLG 191
Cdd:cd24077    37 FENILEILKSIIQELISQAPKtpygLVGIGIGIHGIVDENEIIFTP-YYDLEDIDLKEKLEEKFNVPVYLENEANLSALA 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1584007151 192 YYKNTGNYDNSSLVYLYSGQngpGAGIMVNGDVVRGSTFFSGEI 235
Cdd:cd24077   116 ERTFSEDYDNLISISIHSGI---GAGIIINNQLYRGYNGFAGEI 156
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 120-235 1.48e-14

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 72.75  E-value: 1.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 120 VNVLSKHIERLIATFPKISSISIGVPGSVD--NGRIFYIPGYEKFQNFNLKSHLEEQFSIPVVIENDMNAAVLGYYKNTG 197
Cdd:cd24065    39 LDALARAVEALQAEAPGVEAVGLGVPGPLDfrRGRVRFAPNIPGLTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGA 118

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1584007151 198 NYDNSSLVYLySGQNGPGAGIMVNGDVVRGSTFFSGEI 235
Cdd:cd24065   119 ARGTESSVYV-TISTGIGGGLVLGGRVLRGRHGQAGEI 155
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 127-239 2.35e-13

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 69.69  E-value: 2.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 127 IERLIATFPkISSISIGVPGSVDNGR--IFYIPGYEkFQNFNLKSHLEEQFSIPVVIENDMNAAVLGYYKNTGNYDNSSL 204
Cdd:cd24061    45 VEELREGHD-VSAVGVAAAGFVDADRatVLFAPNIA-WRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDM 122

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1584007151 205 VYLYSGqNGPGAGIMVNGDVVRGSTFFSGE---ISFVP 239
Cdd:cd24061   123 VMITVG-TGLGGGIVIGGKLLRGAFGIAGEfghIRVVP 159
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 136-239 2.61e-13

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 69.63  E-value: 2.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 136 KISSISIGVPGSVD--NGRIFYIPGYeKFQNFNLKSHLEEQFSIPVVIENDMNAAVLG-YYKNTGnyDNSSLVYLYSGQN 212
Cdd:cd24062    61 DLIGIGVGVPGPVDveTGTVEVAVNL-GWKNFPLKDKLEALTGIPVVIDNDANAAALGeMWKGAG--QGAKDLVFITLGT 137

                          90       100
                  ....*....|....*....|....*..
gi 1584007151 213 GPGAGIMVNGDVVRGSTFFSGEISFVP 239
Cdd:cd24062   138 GVGGGVIANGKIVHGANGAAGEIGHIT 164
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 123-235 4.71e-12

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 65.85  E-value: 4.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 123 LSKHIERLIATFP----KISSISIGVPGSVD--NGRIFYIPGYeKFQNFNLKSHLEEQFSIPVVIENDMNAAVLG--YYK 194
Cdd:cd24075    44 LIEEIAQFLKSHRrktqRLIAISITLPGLINpkTGVVHYMPHI-QVKSWPIVEELEQRFNVPCFIGNDIRSLALAehYFG 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1584007151 195 NTGNYDNSSLVYLYsgqNGPGAGIMVNGDVVRGSTFFSGEI 235
Cdd:cd24075   123 ASKDCKDSILVRIH---HGIGAGIIIDGKLFLGQNGNAGEI 160
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 136-235 1.27e-11

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 64.50  E-value: 1.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 136 KISSISIGVPGSVD--NGRIFYIPGYeKFQNFNLKSHLEEQFSIPVVIENDMNAAVL-----GYYKNTGNYdnsSLVYLy 208
Cdd:cd24073    61 RLLGIGVGLPGLVDaeTGICRWSPLL-GWRDVPLAELLEERLGLPVYVENDVNALALaehwfGAGRGLDNF---AVVTI- 135

                          90       100
                  ....*....|....*....|....*..
gi 1584007151 209 sgQNGPGAGIMVNGDVVRGSTFFSGEI 235
Cdd:cd24073   136 --GRGIGCGLVVDGRLYRGAHGGAGEI 160
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 84-284 2.96e-11

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 63.59  E-value: 2.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151  84 GLAIFLEKNETNYTIFNCLGEVK-------EQGSTSSMLIDtgvnVLSKHIERLIATFPK-ISSISIGVPGSVDN--GRI 153
Cdd:cd24072     3 VLGIVVSPNSLRAQVGNACGELLgefeyrvITLETPEALID----EIIDCIDRLLKLWKDrVKGIALAIQGLVDShkGVS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 154 FYIPGYeKFQNFNLKSHLEEQFSIPVVIENDMNA-AVLGYYKNTGNYDNSSLVYLYSgqNGPGAGIMVNGDVVRGSTFFS 232
Cdd:cd24072    79 LWSPGA-PWRNIEIKYLLEERYGIPVFVENDCNMlALAEKWQGELRQSRDFCVINLD--YGIGSAIVIDNKLYIGASSGS 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 233 GEI---------------------SFV----------------------PQYNNKNFLQALRsedSNNPEEYNI-----D 264
Cdd:cd24072   156 GEIghtkvnpdgarcdcgrrgcleTVAsnsalkrnarvtlklgpvsadpEKLTMEQLIEALE---EGEPIATQIfdraaN 232

                         250       260
                  ....*....|....*....|
gi 1584007151 265 AITRLIATCIAIINPHAFIF 284
Cdd:cd24072   233 AIGRSLANILNLLNPEQVLL 252
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 137-238 6.93e-11

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 62.13  E-value: 6.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 137 ISSISIGVPGSVD--NGRIFYIPGYEKFQNFNLKSHLEEQFSIPVVIENDMNAAVLG--YYKNTGNYDNssLVYLYSGqN 212
Cdd:cd24064    56 LLGIGIGSPGSIDreNGIVRFSPNFPDWRNFPLVPLIEERTGIKVFLENDANAFALGewWFGNAKGSNH--IIGLTLG-T 132

                          90       100
                  ....*....|....*....|....*.
gi 1584007151 213 GPGAGIMVNGDVVRGSTFFSGEISFV 238
Cdd:cd24064   133 GVGSGVICHGQLLTGYDGIAAELGHV 158
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 127-227 9.26e-11

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 61.79  E-value: 9.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 127 IERLIATF----PKISSISIGV-------PGSVDNGRIFYIPgyeK--FQNFNLKSHLEEQFSIPVVIENDMNAAVLGYY 193
Cdd:cd24067    37 LQAVIDFFreqeEPIDAIGIASfgpidlnPTSPTYGYITTTP---KpgWRNFDILGALKRAFPVPVGFDTDVNAAALAEY 113

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1584007151 194 KNTGNYDNSSLVYLYSGqNGPGAGIMVNGDVVRG 227
Cdd:cd24067   114 RWGAAKGLDSLAYITVG-TGIGVGLVVNGKPVHG 146
PRK09698 PRK09698
D-allose kinase; Provisional
 108-283 1.52e-08

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 55.37  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 108 QGSTSSMLIDtgvnVLSKHIERLIATfpkISSISIGVPGSVDNGR--IFYIPGYEKF--QNFNLKSHLEEQFSIPVVIEN 183
Cdd:PRK09698   40 APDLVSGLGE----MIDEYLRRFNAR---CHGIVMGFPALVSKDRrtVISTPNLPLTalDLYDLADKLENTLNCPVFFSR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 184 DMNAAVLgYYKNTGNYDNSSLVYLYSGqNGPGAGIMVNGDVVRGSTFFSGEISFVPQYN--------NKNFLQ------A 249
Cdd:PRK09698  113 DVNLQLL-WDVKENNLTQQLVLGAYLG-TGMGFAVWMNGAPWTGAHGVAGELGHIPLGDmtqhcgcgNPGCLEtncsgmA 190

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1584007151 250 LRSEDSNNPEEYNIDAI-----------------TRLIATCIAIINPHAFI 283
Cdd:PRK09698  191 LRRWYEQQPRDYPLSDLfvhagdhpfiqsllenlARAIATSINLFDPDAII 241
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 117-235 2.74e-06

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 48.49  E-value: 2.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 117 DTGVNVLSKHIERL--IATFPKISSISIGVPGSVDN--GRIFYIPGYeKFQNFNLKSHLEEQFSIPVVIENDMNAAVLGY 192
Cdd:cd24063    38 GTVSEQVLGLIETLlsKAGKDSIEGIGVSSAGPLDLrkGTIVNSPNI-KGKEIPLVEPLKEEFNIPVALLNDAVAAALGE 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1584007151 193 Y-----KNTGNydnssLVYLYSGqNGPGAGIMVNGDVVRGSTFFSGEI 235
Cdd:cd24063   117 HlfgagRGTSN-----LVYITIS-TGIGGGVIVDGRLLLGKNGNAAEV 158
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 114-238 3.21e-06

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 48.05  E-value: 3.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 114 MLIDTGVNVLSKHIErliatfpKISSISIGVPGSVDNGRIFYI-PGYEKFQN-FNLKSHLEEQFSIPVVIENDMNAAVLG 191
Cdd:cd24069    36 ALADALASLLADYQG-------QFDRVAVASTGIIRDGVLTALnPKNLGGLSgFPLADALQQLLGVPVVLLNDAQAAAWG 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1584007151 192 YYKNTGNYDNSSLVYLySGQNGPGAGIMVNGDVVRGSTFFSGEISFV 238
Cdd:cd24069   109 EYQAGDGEGVGNLVFI-TVSTGVGGGLVLNGQLLTGPNGLAGHIGHT 154
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 120-235 1.01e-05

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 46.51  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 120 VNVLSKHIERLIATFP---KISSISIGVPGSVDNGR-IFYIPGYEKFQNFNLKSHLEEQFSIPVVIENDMNAAVLGY-YK 194
Cdd:cd24071    42 IELIAENIKKLIKNKHvekKLLGIGIAVSGLVDSKKgIVIRSTILGWENVELKKILKEKFKIPVFIDNDVNSFALAElWK 121

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1584007151 195 NTGNYDNSSLVYLYSgqNGPGAGIMVNGDVVRGSTFFSGEI 235
Cdd:cd24071   122 GKGKGYSNFICVTVG--AGIGSSLVIDGKLYTGNFGGAGEI 160
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 128-239 1.27e-05

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 46.54  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 128 ERLIAtfpkissISIGVPGSVD--NGRIFYIPGYEkFQNFNLKSHLEEQFSIPVVIENDMNAAVL--GYYKNTGNYDNSS 203
Cdd:cd24074    61 ERLTA-------IAITLPGIIDpeSGIVHRLPFYD-IKNLPLGEALEQHTGLPVYVQHDISAWTLaeRFFGAAKGAKNII 132

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1584007151 204 LVYLysgQNGPGAGIMVNGDVVRGSTFFSGEISFVP 239
Cdd:cd24074   133 QIVI---DDDIGAGVITDGQLLHAGSSRLGELGHTQ 165
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 139-235 4.44e-05

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 44.53  E-value: 4.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584007151 139 SISIGVPGSVD--NGRIFY--IPGyekFQNFNLKSHLEEQFSIPVVIENDMNAAVLGYYkNTGNYDNSSLVY-LYSGqNG 213
Cdd:cd24057    59 PVGIGIPGVIDpeDGTLITanIPA---AKGRPLRADLSARLGRPVRIDNDANCFALSEA-WDGAGRGYPSVFgLILG-TG 133

                          90       100
                  ....*....|....*....|..
gi 1584007151 214 PGAGIMVNGDVVRGSTFFSGEI 235
Cdd:cd24057   134 VGGGLVVNGRLVGGRSGIAGEW 155
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
17-82 5.75e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 39.86  E-value: 5.75e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1584007151  17 RGIRKVLLERGSATKVELSNTLEISFPTISKFIEKMKQDGEVtlagldDSSGGRRAKRYEYNPEYM 82
Cdd:COG3398   100 RRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLV------ERERDGRNVRYYLNPPER 159
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 130-191 7.56e-04

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 40.63  E-value: 7.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1584007151 130 LIATFPKISSISIGVPGSVDNGRIFYIPGYEK-FQNFNLKSHLEEQFSIPVVIENDMNAAVLG 191
Cdd:cd24058    48 LVAHFPWFGPVGVGFPGVVRRGVVRTAANLDKsWIGFDAAKLLSKRLGRPVRVLNDADAAGLA 110
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 167-235 2.17e-03

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 39.32  E-value: 2.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1584007151 167 LKSHLEEQFSIPVVIENDMNAAVLGYYKNTGNYDNSSLVYLYSGqNGPGAGIMVNGDVVRGSTFFSGEI 235
Cdd:cd24060    93 LRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITG-TGIGGGIILNHELIHGSSFCAAEL 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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