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Conserved domains on  [gi|1584175995|ref|WP_130874009|]
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GNAT family N-acetyltransferase [[Pseudopropionibacterium] massiliense]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
176-289 2.82e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 54.71  E-value: 2.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 176 TPERSDQVLRLHNSCFSARiDDAAWAESLREEtFRADWSWIAIRGDEVVGYCLSGTDDAAGLDGVmeGWCDRLGVARSHR 255
Cdd:COG3153     5 TPEDAEAIAALLRAAFGPG-REAELVDRLRED-PAAGLSLVAEDDGEIVGHVALSPVDIDGEGPA--LLLGPLAVDPEYR 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1584175995 256 HQGVAQALLCRSLHSMAASGCPAAGIGVDTRNRA 289
Cdd:COG3153    81 GQGIGRALMRAALEAARERGARAVVLLGDPSLLP 114
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
176-289 2.82e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 54.71  E-value: 2.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 176 TPERSDQVLRLHNSCFSARiDDAAWAESLREEtFRADWSWIAIRGDEVVGYCLSGTDDAAGLDGVmeGWCDRLGVARSHR 255
Cdd:COG3153     5 TPEDAEAIAALLRAAFGPG-REAELVDRLRED-PAAGLSLVAEDDGEIVGHVALSPVDIDGEGPA--LLLGPLAVDPEYR 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1584175995 256 HQGVAQALLCRSLHSMAASGCPAAGIGVDTRNRA 289
Cdd:COG3153    81 GQGIGRALMRAALEAARERGARAVVLLGDPSLLP 114
PRK03624 PRK03624
putative acetyltransferase; Provisional
 168-315 4.06e-06

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 45.69  E-value: 4.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 168 PGLVFENFTPERSDQVLRLHNSCFSARIDDAAWAESLREETFRADWSWIAIRGDEVVGYCLsgtddaAGLDGvMEGWCDR 247
Cdd:PRK03624    1 DAMEIRVFRQADFEAVIALWERCDLTRPWNDPEMDIERKLNHDPSLFLVAEVGGEVVGTVM------GGYDG-HRGWAYY 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1584175995 248 LGVARSHRHQGVAQALLCRSLHSMAASGCPAAGIGVDTRNRAVADwLHRVLGYEERDSVTlLGKSIPA 315
Cdd:PRK03624   74 LAVHPDFRGRGIGRALVARLEKKLIARGCPKINLQVREDNDAVLG-FYEALGYEEQDRIS-LGKRLIE 139
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 181-300 7.45e-06

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 44.43  E-value: 7.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 181 DQVLRLHNSCFSARIDDAAWAESLREETFRADWSWIAIRGDEVVGYCLSGTDDaaglDGVMEGWCDRLGVARSHRHQGVA 260
Cdd:pfam00583   2 EALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIID----DEPPVGEIEGLAVAPEYRGKGIG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1584175995 261 QALLCRSLHSMAASGCPAAGIGVDTRNRAVADwLHRVLGY 300
Cdd:pfam00583  78 TALLQALLEWARERGCERIFLEVAADNLAAIA-LYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 214-277 1.57e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.18  E-value: 1.57e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1584175995 214 SWIAIRGDEVVGYCLSGTDDAAGldgvMEGWCDRLGVARSHRHQGVAQALLCRSLHSMAASGCP 277
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGG----DTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAK 60
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
176-289 2.82e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 54.71  E-value: 2.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 176 TPERSDQVLRLHNSCFSARiDDAAWAESLREEtFRADWSWIAIRGDEVVGYCLSGTDDAAGLDGVmeGWCDRLGVARSHR 255
Cdd:COG3153     5 TPEDAEAIAALLRAAFGPG-REAELVDRLRED-PAAGLSLVAEDDGEIVGHVALSPVDIDGEGPA--LLLGPLAVDPEYR 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1584175995 256 HQGVAQALLCRSLHSMAASGCPAAGIGVDTRNRA 289
Cdd:COG3153    81 GQGIGRALMRAALEAARERGARAVVLLGDPSLLP 114
PRK03624 PRK03624
putative acetyltransferase; Provisional
 168-315 4.06e-06

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 45.69  E-value: 4.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 168 PGLVFENFTPERSDQVLRLHNSCFSARIDDAAWAESLREETFRADWSWIAIRGDEVVGYCLsgtddaAGLDGvMEGWCDR 247
Cdd:PRK03624    1 DAMEIRVFRQADFEAVIALWERCDLTRPWNDPEMDIERKLNHDPSLFLVAEVGGEVVGTVM------GGYDG-HRGWAYY 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1584175995 248 LGVARSHRHQGVAQALLCRSLHSMAASGCPAAGIGVDTRNRAVADwLHRVLGYEERDSVTlLGKSIPA 315
Cdd:PRK03624   74 LAVHPDFRGRGIGRALVARLEKKLIARGCPKINLQVREDNDAVLG-FYEALGYEEQDRIS-LGKRLIE 139
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 181-300 7.45e-06

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 44.43  E-value: 7.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 181 DQVLRLHNSCFSARIDDAAWAESLREETFRADWSWIAIRGDEVVGYCLSGTDDaaglDGVMEGWCDRLGVARSHRHQGVA 260
Cdd:pfam00583   2 EALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIID----DEPPVGEIEGLAVAPEYRGKGIG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1584175995 261 QALLCRSLHSMAASGCPAAGIGVDTRNRAVADwLHRVLGY 300
Cdd:pfam00583  78 TALLQALLEWARERGCERIFLEVAADNLAAIA-LYEKLGF 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 215-302 2.55e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 42.06  E-value: 2.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 215 WIAIRGDEVVGYClsgtdDAAGLDGVMEGWCDRLGVARSHRHQGVAQALLCRSLHSMAASGCpaAGIGVDTRNRAVAdwL 294
Cdd:pfam13508   6 FVAEDDGKIVGFA-----ALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGI--KLLELETTNRAAA--F 76


                  ....*...
gi 1584175995 295 HRVLGYEE 302
Cdd:pfam13508  77 YEKLGFEE 84
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 225-304 3.55e-05

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 41.95  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 225 GYCLSGTDDAAGldgvmEGWCDRLGVARSHRHQGVAQALLCRSLHSMAASGCPAAGIGVDTRN-RAVAdwLHRVLGYEER 303
Cdd:COG0456     1 GFALLGLVDGGD-----EAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNeAAIA--LYEKLGFEEV 73


                  .
gi 1584175995 304 D 304
Cdd:COG0456    74 G 74
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
195-302 4.52e-05

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 43.06  E-value: 4.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 195 IDDAAWAESLREETFRADWSWIAIRGDEVVGYC-LSGTDDAAGLDGVMEgwcDRLGVARSHRHQGVAQALLCRSLHSMAA 273
Cdd:COG1247    35 PSEEEREAWFAAILAPGRPVLVAEEDGEVVGFAsLGPFRPRPAYRGTAE---ESIYVDPDARGRGIGRALLEALIERARA 111

                          90       100
                  ....*....|....*....|....*....
gi 1584175995 274 SGCPAAGIGVDTRNRAvADWLHRVLGYEE 302
Cdd:COG1247   112 RGYRRLVAVVLADNEA-SIALYEKLGFEE 139
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 214-277 1.57e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.18  E-value: 1.57e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1584175995 214 SWIAIRGDEVVGYCLSGTDDAAGldgvMEGWCDRLGVARSHRHQGVAQALLCRSLHSMAASGCP 277
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGG----DTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAK 60
Eis COG4552
Predicted acetyltransferase [General function prediction only];
170-279 1.62e-04

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 42.96  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 170 LVFENFTPERSDQVLRLHNSCFSARIDDAAWAESLREetFRADWSWIAIRGDEVVGYCLS--------GTD-DAAGLDGV 240
Cdd:COG4552     1 MEIRPLTEDDLDAFARLLAYAFGPEPDDEELEAYRPL--LEPGRVLGVFDDGELVGTLALypftlnvgGARvPMAGITGV 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1584175995 241 megwcdrlGVARSHRHQGVAQALLCRSLHSMAASGCPAA 279
Cdd:COG4552    79 --------AVAPEHRRRGVARALLREALAELRERGQPLS 109
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 176-279 2.78e-04

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 39.86  E-value: 2.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 176 TPERSDQVLRLHNSCFSARIDDAAWAesLREETFRADWSWIAIRGDEVVG---------YCLSGTDDAAGLDGVMegwcd 246
Cdd:pfam13527   5 TEDEFDEVLRLLEYAFQDEDSPELRE--YFRPLLEEGRVLGAFDDGELVStlalypfelNVPGKTLPAAGITGVA----- 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1584175995 247 rlgVARSHRHQGVAQALLCRSLHSMAASGCPAA 279
Cdd:pfam13527  78 ---TYPEYRGRGVMSRLLRRSLEEMRERGVPLS 107
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 193-308 6.05e-04

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 39.20  E-value: 6.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 193 ARIDDAAWAESLREETFRADWS---WIAIRGDEVVGYClsgtddaaGLDGVMEGWC--DRLGVARSHRHQGVAQALLCRS 267
Cdd:COG1246     6 ATPDDVPAILELIRPYALEEEIgefWVAEEDGEIVGCA--------ALHPLDEDLAelRSLAVHPDYRGRGIGRRLLEAL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1584175995 268 LHSMAASGCPAagIGVDTRNRAVaDWLHRvLGYEERDSVTL 308
Cdd:COG1246    78 LAEARELGLKR--LFLLTTSAAI-HFYEK-LGFEEIDKEDL 114
PRK01346 PRK01346
enhanced intracellular survival protein Eis;
176-279 3.42e-03

enhanced intracellular survival protein Eis;


Pssm-ID: 234945 [Multi-domain]  Cd Length: 411  Bit Score: 38.76  E-value: 3.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1584175995 176 TPERSDQVLRLHNSCFSARIDDAAWAESLREetFRADWSWIAIRGDEVVGYCLS----------GTDDAAGLDGVmegwc 245
Cdd:PRK01346   13 TEEDWPAWFRAAATGFGDSPSDEELEAWRAL--VEPDRTLGAFDGDEVVGTAGAfdlrltvpggAVLPAAGVTAV----- 85

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1584175995 246 drlGVARSHRHQGVAQALLCRSLHSMAASGCPAA 279
Cdd:PRK01346   86 ---TVAPTHRRRGLLTALMREQLRRIRERGEPVA 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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