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Conserved domains on  [gi|1589895752|ref|WP_131316566|]
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MULTISPECIES: MFS transporter [Paraburkholderia]

Protein Classification

MFS transporter( domain architecture ID 13022908)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
28-426 9.63e-85

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 263.28  E-value: 9.63e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  28 WRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLM 107
Cdd:cd17319     2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 108 AAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLlhldgvLGLAG 187
Cdd:cd17319    82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL------LLLFG 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 188 WRWMFIIEGLPACVVGFLVLKMLAdrpadarwlspaerdalqgafdregsssrkekhfgaalrdvRVYILALISFGFTMG 267
Cdd:cd17319   156 WRWAFIIEGLLGLLLAVLWWFYLR-----------------------------------------QVWGLALGYFGINYA 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 268 SYGIGIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDR--RGGAIANLAAGLLIGGVALGVSTHFHQLGPA 344
Cdd:cd17319   195 LYGLLTWLPTYLKqARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTTSPVVA 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 345 MVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLL 424
Cdd:cd17319   275 VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALL 354

                  ..
gi 1589895752 425 TL 426
Cdd:cd17319   355 VL 356
 
Name Accession Description Interval E-value
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
28-426 9.63e-85

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 263.28  E-value: 9.63e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  28 WRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLM 107
Cdd:cd17319     2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 108 AAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLlhldgvLGLAG 187
Cdd:cd17319    82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL------LLLFG 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 188 WRWMFIIEGLPACVVGFLVLKMLAdrpadarwlspaerdalqgafdregsssrkekhfgaalrdvRVYILALISFGFTMG 267
Cdd:cd17319   156 WRWAFIIEGLLGLLLAVLWWFYLR-----------------------------------------QVWGLALGYFGINYA 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 268 SYGIGIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDR--RGGAIANLAAGLLIGGVALGVSTHFHQLGPA 344
Cdd:cd17319   195 LYGLLTWLPTYLKqARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTTSPVVA 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 345 MVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLL 424
Cdd:cd17319   275 VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALL 354

                  ..
gi 1589895752 425 TL 426
Cdd:cd17319   355 VL 356
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
36-428 1.06e-77

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 246.86  E-value: 1.06e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  36 LAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAV 115
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 116 GPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGWRWMFIIE 195
Cdd:TIGR00893  81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILI------HFSWQWAFIIE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 196 GLPACVVGFLVLKMLADRPADARWLSPAERDALQGAFDRE----GSSSRKEKHFGAALRDVRVYILALISFGFTMGSYGI 271
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEqqgkGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFF 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 272 GIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRG------------GAIANLAAGLLIGGVALGVSTHF 338
Cdd:TIGR00893 235 LTWFPTYLVqERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLrrgkslvfarktAIIAGLVLSLLMFATNYVNIPYA 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 339 hqlgpAMVGVTLALIGTIAGrTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVL 418
Cdd:TIGR00893 315 -----ALALVALGFFGLGAG-AIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALA 388
                         410
                  ....*....|
gi 1589895752 419 GITTLLTLSL 428
Cdd:TIGR00893 389 LIGALSYLLL 398
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
20-428 1.94e-58

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 195.47  E-value: 1.94e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  20 QQAVRKAAWRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLAR 99
Cdd:COG2271     1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 100 IMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHl 179
Cdd:COG2271    81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 180 dgvlgLAGWRWMFIIEGLPACVVGFLvlkmladrpadarwlspaerdalqgafdregsssrkekhfgaalrdvRVYILAL 259
Cdd:COG2271   160 -----AFGWRAAFLILGLPGLLLALL-----------------------------------------------RFWLLAL 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 260 ISFGFTMGSYGIGIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRG-GAIANLAAGLLIGGVALGVSTH 337
Cdd:COG2271   188 AYFLVYFALYGFLTWLPTYLVeVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrRRKLVLAIGLLLAALALLLLAL 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 338 FHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGtFTAGMMGLAIV 417
Cdd:COG2271   268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAAL 346
                         410
                  ....*....|.
gi 1589895752 418 LGITTLLTLSL 428
Cdd:COG2271   347 ALLAALLALLL 357
MFS_1 pfam07690
Major Facilitator Superfamily;
34-394 4.27e-26

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 107.89  E-value: 4.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  34 LALAYFFNYLDRTSVGFA-ALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATS 112
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 113 FAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGWRWMF 192
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS------LFGWRAAF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 193 IIEGLPACVVGFLVLkmLADRPADARWLSPAERDALQGAFDREgsssrkekhfgaALRDVRVYILALISFGFTMGSYGIG 272
Cdd:pfam07690 155 LILAILSLLAAVLLL--LPRPPPESKRPKPAEEARLSLIVAWK------------ALLRDPVLWLLLALLLFGFAFFGLL 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 273 IWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLAL 352
Cdd:pfam07690 221 TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLL 300
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1589895752 353 IGTIAG--RTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGP 394
Cdd:pfam07690 301 LGFGFGlvFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
43-416 6.00e-09

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 57.66  E-value: 6.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  43 LDRTSVGFAALTMNKDLGLTATQFGW--GAGI-------MFAGYcicevpsnLAlYRFGARRWLARIMITWGLMAAATSF 113
Cdd:PRK11551   29 LDLQSAGVAAPRMAQEFGLDVAQMGWafSAGIlgllpgaLLGGR--------LA-DRIGRKRILIVSVALFGLFSLATAQ 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 114 AVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLlhldgvLGLAGWRWMFI 193
Cdd:PRK11551  100 AWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLA------AGDAAWRHIFY 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 194 IEGlpacVVGFLVLKMLadrpadARWLsPAERDALQGAFDREGSSSRKEKHFGAALRdvRVYILALISFGFT-MGSYGIG 272
Cdd:PRK11551  174 VGG----VGPLLLVPLL------MRWL-PESRAFAQAAGAGKQRAPVLRALFGEGRA--TATLLLWISYFFTlIVLYFLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 273 IWLPQMLKAHGMTVAQTGWlsaVPYFF------ATIALLWWAKRVdRRGGAIANLAAGLLIGGVALGVSTHFhqlGPAMV 346
Cdd:PRK11551  241 NWLPSLLVGQGLSRSQAGL---VQIAFniggalGSLLIGALMDRL-RPRRVVLLIYAGILASLAALAAAPSF---AGMLL 313
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 347 GVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKdSYGTFTAGMMGLAI 416
Cdd:PRK11551  314 AGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLL-ALGRSTVGVIGASI 382
 
Name Accession Description Interval E-value
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
28-426 9.63e-85

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 263.28  E-value: 9.63e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  28 WRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLM 107
Cdd:cd17319     2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 108 AAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLlhldgvLGLAG 187
Cdd:cd17319    82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL------LLLFG 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 188 WRWMFIIEGLPACVVGFLVLKMLAdrpadarwlspaerdalqgafdregsssrkekhfgaalrdvRVYILALISFGFTMG 267
Cdd:cd17319   156 WRWAFIIEGLLGLLLAVLWWFYLR-----------------------------------------QVWGLALGYFGINYA 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 268 SYGIGIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDR--RGGAIANLAAGLLIGGVALGVSTHFHQLGPA 344
Cdd:cd17319   195 LYGLLTWLPTYLKqARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTTSPVVA 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 345 MVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLL 424
Cdd:cd17319   275 VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALL 354

                  ..
gi 1589895752 425 TL 426
Cdd:cd17319   355 VL 356
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
36-428 1.06e-77

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 246.86  E-value: 1.06e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  36 LAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAV 115
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 116 GPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGWRWMFIIE 195
Cdd:TIGR00893  81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILI------HFSWQWAFIIE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 196 GLPACVVGFLVLKMLADRPADARWLSPAERDALQGAFDRE----GSSSRKEKHFGAALRDVRVYILALISFGFTMGSYGI 271
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEqqgkGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFF 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 272 GIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRG------------GAIANLAAGLLIGGVALGVSTHF 338
Cdd:TIGR00893 235 LTWFPTYLVqERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLrrgkslvfarktAIIAGLVLSLLMFATNYVNIPYA 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 339 hqlgpAMVGVTLALIGTIAGrTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVL 418
Cdd:TIGR00893 315 -----ALALVALGFFGLGAG-AIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALA 388
                         410
                  ....*....|
gi 1589895752 419 GITTLLTLSL 428
Cdd:TIGR00893 389 LIGALSYLLL 398
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
20-428 1.94e-58

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 195.47  E-value: 1.94e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  20 QQAVRKAAWRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLAR 99
Cdd:COG2271     1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 100 IMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHl 179
Cdd:COG2271    81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 180 dgvlgLAGWRWMFIIEGLPACVVGFLvlkmladrpadarwlspaerdalqgafdregsssrkekhfgaalrdvRVYILAL 259
Cdd:COG2271   160 -----AFGWRAAFLILGLPGLLLALL-----------------------------------------------RFWLLAL 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 260 ISFGFTMGSYGIGIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRG-GAIANLAAGLLIGGVALGVSTH 337
Cdd:COG2271   188 AYFLVYFALYGFLTWLPTYLVeVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrRRKLVLAIGLLLAALALLLLAL 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 338 FHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGtFTAGMMGLAIV 417
Cdd:COG2271   268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAAL 346
                         410
                  ....*....|.
gi 1589895752 418 LGITTLLTLSL 428
Cdd:COG2271   347 ALLAALLALLL 357
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
28-333 1.82e-54

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 186.30  E-value: 1.82e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  28 WRFIPLLALAYFFNYLDRTSVGFAALT-MNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGL 106
Cdd:cd17327     4 LFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 107 MAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHLDGVLGLA 186
Cdd:cd17327    84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGLA 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 187 GWRWMFIIEGLPACVVGFLVLKMLADRPADARWLSPAERDAlqgAFDR-------EGSSSRKEKHFGAALRDVRVYILAL 259
Cdd:cd17327   164 GWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKEL---AVERlranqtgKGDQKFKWKQIKEAFKDPRTWLLFL 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1589895752 260 ISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALL---WWAKRVDRRGGAIANLAAGLLIGGVALG 333
Cdd:cd17327   241 FFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLiaaLLSDRFKKRGLFAIFACVLALVGSIILL 317
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
25-435 1.05e-52

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 181.23  E-value: 1.05e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  25 KAAWRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITW 104
Cdd:COG2223     1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 105 GLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLlhldgvLG 184
Cdd:COG2223    81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL------IA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 185 LAGWRWMFIIEGLPACVVGFLVLKMLADRPADARWLSPAERdalqgafdregsssrkeKHFGAALRDVRVYILALISFGF 264
Cdd:COG2223   155 AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASL-----------------RDQLEALRDPRFWLLSLLYFGT 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 265 TMGSYGIGIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGP 343
Cdd:COG2223   218 FGSFIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWL 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 344 AMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTL 423
Cdd:COG2223   298 FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
                         410
                  ....*....|..
gi 1589895752 424 LTLSLYAFNREK 435
Cdd:COG2223   378 LTLLLYRRPRRA 389
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
21-390 1.83e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 109.29  E-value: 1.83e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  21 QAVRKAAWRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARI 100
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 101 MITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHld 180
Cdd:COG2814    82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 181 gvlgLAGWRWMFIIEGLPACVVGFLVLKMLADRPADARwlspaerdalqgafdregssSRKEKHFGAALRDVRVYILALI 260
Cdd:COG2814   160 ----LFGWRWVFLVNAVLALLALLLLLRLLPESRPAAR--------------------ARLRGSLRELLRRPRLLLLLLL 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 261 SFGFTMGSYGIGIWLPQMLKA-HGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVALGVSTHFH 339
Cdd:COG2814   216 AFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL-LLIGLLLLALGLLLLALAG 294
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1589895752 340 QLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGG 390
Cdd:COG2814   295 SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
34-394 4.27e-26

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 107.89  E-value: 4.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  34 LALAYFFNYLDRTSVGFA-ALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATS 112
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 113 FAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGWRWMF 192
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS------LFGWRAAF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 193 IIEGLPACVVGFLVLkmLADRPADARWLSPAERDALQGAFDREgsssrkekhfgaALRDVRVYILALISFGFTMGSYGIG 272
Cdd:pfam07690 155 LILAILSLLAAVLLL--LPRPPPESKRPKPAEEARLSLIVAWK------------ALLRDPVLWLLLALLLFGFAFFGLL 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 273 IWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLAL 352
Cdd:pfam07690 221 TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLL 300
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1589895752 353 IGTIAG--RTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGP 394
Cdd:pfam07690 301 LGFGFGlvFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
34-426 2.98e-24

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 103.28  E-value: 2.98e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  34 LALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSF 113
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 114 AVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgVLGLAGWRWMFI 193
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA----SSLGFGWRAVFL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 194 IEGLPACVVGFLVLKMLADRPADARwlspaerdalqgAFDREGSSSRKEKHFGAALRDVRVYILALISFGFTMGSYGIGI 273
Cdd:cd06174   157 IAAALALLAAILLLLVVPDPPESAR------------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFST 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 274 WLPQMLKAHGM-TVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLAL 352
Cdd:cd06174   225 LLPLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG 304
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1589895752 353 IGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:cd06174   305 FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
14-428 4.75e-24

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 103.03  E-value: 4.75e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  14 NASSIEQQAVRKAAWRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGA 93
Cdd:COG2807     3 TTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  94 RRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQyRTRVLAWFTVSTPLSSLIGAPLS 173
Cdd:COG2807    83 ERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLT 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 174 TWLLHLdgvlglAGWRWMFIIEGLPACVVGFLVLKMLADRPADARwlspaerdalqgafdregsSSRKEKHFGAALRDVR 253
Cdd:COG2807   162 VPLAAA------LGWRGALAVWALLALLALLLWLPLLRRRPAAAA-------------------AAPAAASLRSLWRSPL 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 254 VYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFF---ATIALLWWAKRVDRRGGAIANLAAGLLIGGV 330
Cdd:COG2807   217 AWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAgipGSLLVPLLADRLGDRRPLLLLLGLLGLAGLL 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 331 ALGvsthFHQLGPAMVGVTLALIGTIAGRTIFYTLPA-RFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTA 409
Cdd:COG2807   297 GLL----LAPGSLPWLWAVLLGLGQGGLFPLALTLIGlRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTA 372
                         410
                  ....*....|....*....
gi 1589895752 410 GMMGLAIVLGITTLLTLSL 428
Cdd:COG2807   373 ALLLLAALAVLMLVAGLLA 391
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
31-430 6.86e-21

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 93.39  E-value: 6.86e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  31 IPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAA 110
Cdd:cd17380     1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 111 TSFAVGPNSFYVI--RLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGW 188
Cdd:cd17380    81 TPLLAYSSLPLLIlsRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE------YYGW 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 189 RWMFIIEGLPACVVGFLVLKMLAdrpadARWlspaerdalqgafdregsssrkekhfgaalrdvrvyilALISFGFTM-- 266
Cdd:cd17380   155 PSVFYFFGLLGLLWALVWLIYLP-----PVW--------------------------------------AIIVAHFCMnw 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 267 GSYGIGIWLPQMLKAHGMTVAQTGWLSAVPY---FFATIALLWWAKRVDRRGGAIANL-----AAGLLIGGVALGVSTHF 338
Cdd:cd17380   192 GFYILLSWLPTYFHEVLVPLAKGWVFNVVPWlvmFPSSNVAGWLADHLISRGWTVTSVrklmqSIGFLGPALFLLLLSHT 271
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 339 HQLGPAMVGVTLALIGTIAGRTIFYTLPARfLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAgMMGLAIVL 418
Cdd:cd17380   272 DSFSLALLCMSVALGLSAFSSSGVLVNHQD-IAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSL-VFVLAAVV 349
                         410
                  ....*....|..
gi 1589895752 419 GITTLLTLSLYA 430
Cdd:cd17380   350 NLVGAVVFLLFG 361
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
16-400 2.58e-19

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 89.34  E-value: 2.58e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  16 SSIEQQAVRKAAWRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARR 95
Cdd:TIGR00895   4 NNIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRR 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  96 WLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTW 175
Cdd:TIGR00895  84 VLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGW 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 176 LlhldgvLGLAGWRWMFIIEGLPACVVGFLVLKMLadrPADARWL---------------SPAERDALQGAFDREGSSSR 240
Cdd:TIGR00895 164 L------IPVFGWRSLFYVGGIAPLLLLLLLMRFL---PESIDFLvskrpetvrrivnaiAPQMQAEAQSALPEQKSTQG 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 241 KEKH-FGAALRDVRVYILALISFGFTMGS---YGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGg 316
Cdd:TIGR00895 235 TKRSvFKALFQGKTARITVLLWLLYFMLLvgvYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLG- 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 317 aiANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIG--TIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGP 394
Cdd:TIGR00895 314 --PRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGffVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGP 391

                  ....*.
gi 1589895752 395 YLVGYL 400
Cdd:TIGR00895 392 ILAGYL 397
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
57-429 1.27e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 83.78  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  57 KDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRwlariMITWGLMAAATS---FAVGPN--SFYVIRLLLGIGE 131
Cdd:cd17325    24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKR-----LLLLGLLLLAVStllFAFATSywQLLLARFLQGLAS 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 132 AGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgvlGLAGWRWMFIIEGLPACVVGFLVLKMLA 211
Cdd:cd17325    99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA------DALGYRAPFLVCAALALLALVLALLLLP 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 212 DRPADARwlspaerdalqgafDREGSSSRKEKHFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAH-GMTVAQTG 290
Cdd:cd17325   173 EPRPPPN--------------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIG 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 291 WL---SAVPYFFATIALLWWAKRVDRRGgaiaNLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYTLPA 367
Cdd:cd17325   239 LLfgaQGLASALSQPPAGKLSDRIGRKP----LILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA 314
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1589895752 368 RFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGtFTAGMMGLAIVLGITTLLTLSLY 429
Cdd:cd17325   315 DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLLR 375
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
36-405 2.04e-17

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 83.58  E-value: 2.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  36 LAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAV 115
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 116 GPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLStwllhLDGVLGLAGWRWMFIIE 195
Cdd:TIGR00881  82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLV-----LFGIAELYSWHWVFIVP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 196 GLPACVVGFLVLKMLADRPADARwLSPAER---DALQGAFDREGSSSRKEKHFGAALRDVRVYILALISFGFTMG-SYGI 271
Cdd:TIGR00881 157 GIIAIIVSLICFLLLRDSPQSCG-LPPAEEmpnEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVvRTGI 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 272 GIWLPQ-MLKAHGMTVAQTGWLSAVPYFFATIALLWWA----KRVDRRGGAIANLAAGLLIggVALGVSTHFHQLGPAMV 346
Cdd:TIGR00881 236 LDWSPLyLTQEKGFSKEKASWAFTLYELGGLVGTLLAGwlsdKLFNGRRGPLAVFFMALII--VSLLVYWLNPAANPLMD 313
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1589895752 347 GVTLALIGTIAGRTIFYT--LPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYG 405
Cdd:TIGR00881 314 LICLFALGFLVYGPQMLIgvIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
32-429 1.32e-16

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 81.13  E-value: 1.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  32 PLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGaRRWLARIMIT-WGLMAAA 110
Cdd:cd17328     2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN-RKWILAVGILiWSAATLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 111 TSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHLDGvlglaGWRW 190
Cdd:cd17328    81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG-----GWRW 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 191 MFIIEGLPACVVGFLVLKMLADRPadarwlspaerdalQGAFDREGSSSRKEKHFGAALRDV-RVYILALISFGFTMGSY 269
Cdd:cd17328   156 AFRVTGVLGVLLAILLLLFVREPP--------------RGAAEGGVMAKSTATSFLADLKALaKNPSFILSTLGFTAVSF 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 270 GIG---IWLPQ-MLKAHGMTVAQT-------GWLSAVPYFFATIALLWWAKRVDRRggaiaNLAAGLLIGGVALGVSTHF 338
Cdd:cd17328   222 VTGalaFWAPTfFLRAFGVGDLSSadvglifGAITCIAGVLGVLLGGILADRLRRK-----TPRADPLVCAVGLLAAAPF 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 339 hqLGPAMVGV---TLALIGTIAGRTIFYTL--------------PARFLSGQAAaggFALINSIgaLGGFAGPYLVGYLK 401
Cdd:cd17328   297 --LFLALVLAlsnLLLAWVLLFLGEFLLSLnwapvfaillyvviPTRRSTASAI---QILLSHL--LGDAGSPYLIGLIS 369
                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1589895752 402 DSYGT--------FTAGMMGLAIVLGITTLLTLSLY 429
Cdd:cd17328   370 DLLRQnkdsplaeAASLQYALLLCSFVLVLGGFFFL 405
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
33-426 7.28e-16

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 78.41  E-value: 7.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  33 LLALAYFFNYLDRTSVGFAALTM--NKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAA 110
Cdd:cd17316     3 LAGLGWFFDAYDFFLIGFVAPVLaaEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 111 TSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHLDGvlGLAGWRW 190
Cdd:cd17316    83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLS--GDWGWRI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 191 MFIIEGLPACVVGFLVLKMLadrpadarwlspaerdalqgafdregsssrkekhfgaalrdvrvyILALISFGFTMGSYG 270
Cdd:cd17316   161 LFLIGALPALLALLLRRRTL---------------------------------------------LLILLWFFISFGYYG 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 271 IGIWLPQMLKAH-GMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVT 349
Cdd:cd17316   196 LTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLL 275
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1589895752 350 LALIGTIAGRT-IFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:cd17316   276 FILSFFVGGVWgALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
31-430 1.52e-15

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 77.63  E-value: 1.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  31 IPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAA 110
Cdd:cd17365     1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 111 TSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgvlGLAGWRW 190
Cdd:cd17365    81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALI------PAFGWRS 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 191 MFIIEGLPACVVGFLVLKMLAdrpadarwlspaerdalqgafdregsssrkekhfgaalrdvrvyiLALISFGFTMGSYG 270
Cdd:cd17365   155 VFLLGGVPPLILLPLLRGTLL---------------------------------------------LWVTFFMGLLLVYL 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 271 IGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTL 350
Cdd:cd17365   190 LNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFL 269
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 351 ALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTLSLYA 430
Cdd:cd17365   270 AGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLRL 349
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
52-425 7.61e-14

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 72.67  E-value: 7.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  52 ALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMI-----TWGLMAAATSFAVgpnsFYVIRLL 126
Cdd:cd17341    22 GPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLlllipLLALALAVSSYWG----LLVLGFL 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 127 LGIGEAGFFPGvIFFLALWFPAQYRTRVL----AWFTVSTPLSSLIGAPLSTWLLHLDGVLGlagWRWMFIIEGLPACVV 202
Cdd:cd17341    98 LGFAGANFASG-QPWASFWFPKEKIGGAAggiaGAGNMGVAVSQLLAPLIAGAIVFDGGFVG---WRNAFFVPGILLAIA 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 203 GFLVLKMLADRPADARWLSPAERDALqgafdregsssrkekhfgAALRDVRVYILALIsFGFTMGSY-GIGIWLPQMLKA 281
Cdd:cd17341   174 AVLVLLFGDDLPTGKASALEFLKVQL------------------AVLKNYRTWILSLL-YGVTFGSFvGFSNVLPTYFKT 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 282 H-GMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALI------G 354
Cdd:cd17341   235 RfGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFValglgaG 314
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1589895752 355 TIAGRTiFYTLPARFLSGQAAAGGFalINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLT 425
Cdd:cd17341   315 AGNGSV-FRMVPFIFRRELGAVTGL--VGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLV 382
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
24-429 4.21e-13

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 70.27  E-value: 4.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  24 RKAAWRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMIT 103
Cdd:COG0738     3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 104 WGLMAAATSFAVGPNSFYVIRLLLGIGeAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHLDGVl 183
Cdd:COG0738    83 MALGLLLFALAPSYPLLLLALFLLGLG-LGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLS- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 184 glAGWRWMFIIEGLPACVVGFLVLKMLADRPADarwlspaerdalqgafdREGSSSRKEKHFGAALRDVRVYILALISFG 263
Cdd:COG0738   161 --LSWHLPYLILAVLLLLLALLFLRSKLPEIEE-----------------EEEEAAGSAASLKSLLKNPRLLLGGLAIFL 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 264 FTMGSYGIGIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALL---WWAKRVDRRGGaianLAAGLLIGGVALGVSTHFH 339
Cdd:COG0738   222 YVGAEGAIGDWLPLYLKdVLGLSEATAALGLSLFWGGMTIGRFlggFLLKRFGPVRL----LRLSALLAAVGLLLALLAP 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 340 QLGPAMVGVTLALIGTIAGRTIFYTLPARFLsGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGtFTAGMMGLAIVLG 419
Cdd:COG0738   298 GPWLALIGLALVGLGLSLMFPTIFSLALDGL-GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLVPLVCYL 375
                         410
                  ....*....|
gi 1589895752 420 ITTLLTLSLY 429
Cdd:COG0738   376 LILLLALALK 385
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
90-426 5.84e-13

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 69.91  E-value: 5.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  90 RFGARRWLARIMITWGLMAAATSFAvgpNSFYVI---RLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSS 166
Cdd:cd17473    61 RFGRKRLLIAGLLLYGIGGVAGLFL---DSLYALlasRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGG 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 167 LIGAPLStwllhldGVLGLAGWRWMFIIEGLpACVVGFLVLKMLADRPadarwlspaerdalqgafDREGSSSRKEKHFG 246
Cdd:cd17473   138 VVFLLLG-------GALAEIGWRAPFLVYLL-ALPVLILVLLFLPEPA------------------RKSKSAASPGAATA 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 247 AALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHG-MTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGL 325
Cdd:cd17473   192 AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFA 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 326 LiggVALGVSTHFHQLGPAMVGVTLALIGTIAGRTI--FYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDS 403
Cdd:cd17473   272 L---MALGFLLLALASGLWVVLLGAILAGLGFGLLLptLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNL 348
                         330       340
                  ....*....|....*....|...
gi 1589895752 404 YGTFTAGMMGLAIVLGITTLLTL 426
Cdd:cd17473   349 TGGLSGAFLILGVLALVLAIVLL 371
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
59-420 7.63e-13

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 69.61  E-value: 7.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  59 LGLTATQFGWGAGIMFAGYcicevpsnlALYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGV 138
Cdd:cd17355    42 LAFTVGLLAFGLAQPFVGR---------LLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAV 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 139 IF-FLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGWRWMFIIEGLPACVVGFLVLKMLADRPADa 217
Cdd:cd17355   113 AFaTVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIE------AFGWRTALLVLALLALLVLVPVLLLLRRRPAD- 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 218 rwlsPAERDALQGAFDREGSSSRkekhfgAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGW---LSA 294
Cdd:cd17355   186 ----LALRAYDDASPASPGSTLK------EALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAValaLIG 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 295 VPYFFATIALLWWAKRVDRRggaiANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFY-TLPARFLSGQ 373
Cdd:cd17355   256 LFNIVGRLLSGWLGDRYSPR----RLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTaALAARYFGAR 331
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1589895752 374 AAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAgMMGLAIVLGI 420
Cdd:cd17355   332 SYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTA-AWALAVALGL 377
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
28-305 9.02e-13

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 68.68  E-value: 9.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  28 WRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLM 107
Cdd:COG0477    13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 108 AAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAG 187
Cdd:COG0477    93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA------ALG 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 188 WRWMFIIEGLPACVVGFLVLKMLADRPADARWLSPAERDALQGAFDREGSSSRKEKHFGAALRDVRVYILALISFGFTMG 267
Cdd:COG0477   167 WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL 246
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1589895752 268 SYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALL 305
Cdd:COG0477   247 LLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLL 284
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
57-418 2.16e-12

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 67.96  E-value: 2.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  57 KDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFP 136
Cdd:cd17324    27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 137 GVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLlhldgvLGLAGWRWMFIIEGLPACVVGFLVLKMLADRPAD 216
Cdd:cd17324   107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL------GQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 217 ARwlspaerdalqgafdregSSSRKEKHFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLK--AHGMTVAQTGWLSA 294
Cdd:cd17324   181 KP------------------GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTdvPGFSSSAIIGLLLL 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 295 vpYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYTLPARfLSGQA 374
Cdd:cd17324   243 --FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR-LAPEA 319
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1589895752 375 AAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVL 418
Cdd:cd17324   320 RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLL 363
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
55-426 3.42e-12

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 67.33  E-value: 3.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  55 MNKDLGLTATQFGWGAGIMFAGYCICEVpsnlaLYRFGARRWLARIMITWGLMA-----AATSFAVGPNSFYVIRLLLGI 129
Cdd:cd06180    25 MLAELGLSYAQAGWIATANYAGYLVGAL-----LASFLRRRGRARRLIRGGLLLtvlllAAMALTSGFAALLALRFLAGA 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 130 GEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAplstwLLHLDGVLGLAGWRWMFIIEGLPACVVGFLVLKM 209
Cdd:cd06180   100 ASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSG-----LLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLL 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 210 LADRPADARWLSPAERdalqgafdregsssrkekhfgAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAQT 289
Cdd:cd06180   175 LRRGPSAPTEASAAES---------------------APGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLA 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 290 GWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVALGVSTHFHQLGPAMVGVTLaLIGTIAGRTIFYTLPARF 369
Cdd:cd06180   234 GLLWSLFGLAAVPSCFLWGALSDRWGTRRA-LAANLLVQAVGVLLPLLSPGPAGLVLSAVL-FGGTFMAITALVMALARE 311
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1589895752 370 LSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:cd06180   312 LAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLAL 368
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
62-428 1.27e-11

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 65.79  E-value: 1.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  62 TATQFGWGAGIMFAGYCIcevpsnlalYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFF 141
Cdd:cd17371    41 TVTLAGGAIGGILGGILA---------DRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAAL 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 142 LALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHLdgVLGLAGWRWMFIIEGLPACVVGFLVLKMladrPADARWLs 221
Cdd:cd17371   112 MAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPL--LPPEIAWRVLFLLGALPALLVLFIRRFV----KEPPQWQ- 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 222 paerdALQGAFDREGSSSRKEKHFGAALRdvRVYILA-LISFGFTMGSYGIGIWLPQMLK-AHGMTVAQTGWLSAVPY-- 297
Cdd:cd17371   185 -----AARAARRHFADRPSLRELFSPPLL--RTTLLAsLLATGALGGYYGITTWLPSYLTgERGLSFEGSAGYLVVTIlg 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 298 -FFATIALLWWAKRVDRRggaiANLAAGLLIGGVALGVSTHFHqLGPAMVGVTLALIGTIAG---RTIFYTLPARFLSGQ 373
Cdd:cd17371   258 gFLGYLAGGFLADRIGRR----NNFALFALGSAISILLYFFLP-LSPTLILILGFPLGFFASgpfSGMGAYLTELFPTAV 332
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1589895752 374 AAAGGFALINsIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTLSL 428
Cdd:cd17371   333 RATAQGFCYN-VGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
47-426 2.00e-11

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 65.34  E-value: 2.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  47 SVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLL 126
Cdd:cd17475    14 GIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 127 LGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLstwllhLDGVLGLAGWRWMFIIEGLPACVVGFLV 206
Cdd:cd17475    94 VGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAAL------LPPLALHYGWRAAFVVAGLVSILAAVLF 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 207 LkmladrpadaRWLSPAERDALQGAFDREGSSSRKEKHFGAALRDVRVYILALISFGFTMGSYgigiWLPQMLKAHGMTV 286
Cdd:cd17475   168 W----------LFYREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTF----LLLFLHDHLGLSV 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 287 AQTGWLSAVPYFFATIALLWWAKRVDRRGG--------AIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAg 358
Cdd:cd17475   234 VAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrrpvlvITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNG- 312
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1589895752 359 rtIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:cd17475   313 --LYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
50-429 1.31e-10

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 62.63  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  50 FAALTMNKDLGLTATQfgwgAGIMFAGYCICEVPSNL---ALY-RFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRL 125
Cdd:cd17329    21 FMAIYLHQQLGLSASI----VGLVLALSAVAGIVASLiggRLAdRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 126 LLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgvlgLAGWRWMFIIEGLpACVVGFL 205
Cdd:cd17329    97 LTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-------LYSFRLLFLAAAV-LFLLAAL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 206 VLkmladrpadARWLSPAERDALQGAFDREGSSSRkekhfgAALRDVRVYILALISFGFTMGSYGIGIWLPQMLK-AHGM 284
Cdd:cd17329   169 VL---------LFLLPETRPKRRAAEKTEILRGYK------IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVeILGL 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 285 TVAQTGWLSAVPyFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYT 364
Cdd:cd17329   234 GESLLGLLLALN-ALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQT 312
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1589895752 365 LPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGtFTAGMMGLAIVLGITTLLTLSLY 429
Cdd:cd17329   313 LVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG-PGLPWLILAALGLIAAALLLGLQ 376
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
122-400 7.51e-10

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 60.53  E-value: 7.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 122 VIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHLDGvlglaGWRWMFIIEGLPACV 201
Cdd:TIGR00894 136 FCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWG-----GWPMIFYVFGIVGCA 210
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 202 VGFLVLKMLADRPADARWLSPAERDALQGAFDREGSSSRKEKHFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKA 281
Cdd:TIGR00894 211 WSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISW 290
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 282 H-GMTVAQTGWLSAVPYFFATI------ALLWW--AKRVDRRGGA--IANLAAGLLIGgvALGVSTHFhqLGPAMVGVTL 350
Cdd:TIGR00894 291 VlRVSGKENGLLSSLPYLFAWLcsifagYLADFlkSSKTLSLTAArkIFNGIGGLGPG--IFAYALPY--LSAAFYLTII 366
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1589895752 351 ALigTIAGRTIFYTLPARFLSGQAAAGGFA-LINSIGALGGFAGPYLVGYL 400
Cdd:TIGR00894 367 IL--TLANAVSSGPLAGVLINSLDLAPRFLgFIKGITGLPGFIGGLIASTL 415
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
57-433 1.74e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 59.14  E-value: 1.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  57 KDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFP 136
Cdd:cd17489    24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 137 GVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGWRWMFIIEGLpACVVGFLVLKMLADRPAD 216
Cdd:cd17489   104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ------HLGFAVLFIVAAV-LALLALLLVFLVKDPPPV 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 217 ArwlspaerdalqgafdreGSSSRKEKHFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAqtGWLSAVP 296
Cdd:cd17489   177 A------------------AEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNA--GLFFTVY 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 297 YFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAA 376
Cdd:cd17489   237 AIALLLSRPFSGKLSDRKGPKTV-IIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRG 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1589895752 377 GGFALINSIGALGGFAGPYLVGYLKDSYGtfTAGMMGLAIVLgitTLLTLSLYAFNR 433
Cdd:cd17489   316 AANGTFFIFFDLGIGLGGLLLGLVAELFG--YRAMFLLAAVV---VLLALVLYIFLL 367
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
28-424 5.77e-09

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 57.67  E-value: 5.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  28 WRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLM 107
Cdd:cd17312     2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 108 AAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgvlGLAG 187
Cdd:cd17312    82 NIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLA------SYYG 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 188 WRWMFIIEGLPACVVGFLVLKMLADRPAdarwlspaerdalqgafdregsssrkekhfgaalrdvRVYILALISFGFTMG 267
Cdd:cd17312   156 WRAAFLVPGIVGLVVAIILFFFLRDSPP-------------------------------------YVWVLSLAYAFVYIV 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 268 SYGIGIWLPQMLKA-HGMTVAQTGWLS---AVPYFFATIALLWWAKRVD--RRGGAIANLAAGLLIGGVALGVSTHfhql 341
Cdd:cd17312   199 RYACLDWGPLYLYEvKGYSLIDAGWFSslyEVGGIAGTILAGLLSDKLFggRRAPIAVIYMLLMTLSLALFWFFPH---- 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 342 GPAMVGVTLALIG-TIAGRTIFYTL--PARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVL 418
Cdd:cd17312   275 NKLLSIVLLFLIGfFVGGPINLIGGaaAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAAL 354

                  ....*.
gi 1589895752 419 GITTLL 424
Cdd:cd17312   355 LSVLLL 360
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
43-416 6.00e-09

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 57.66  E-value: 6.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  43 LDRTSVGFAALTMNKDLGLTATQFGW--GAGI-------MFAGYcicevpsnLAlYRFGARRWLARIMITWGLMAAATSF 113
Cdd:PRK11551   29 LDLQSAGVAAPRMAQEFGLDVAQMGWafSAGIlgllpgaLLGGR--------LA-DRIGRKRILIVSVALFGLFSLATAQ 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 114 AVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLlhldgvLGLAGWRWMFI 193
Cdd:PRK11551  100 AWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLA------AGDAAWRHIFY 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 194 IEGlpacVVGFLVLKMLadrpadARWLsPAERDALQGAFDREGSSSRKEKHFGAALRdvRVYILALISFGFT-MGSYGIG 272
Cdd:PRK11551  174 VGG----VGPLLLVPLL------MRWL-PESRAFAQAAGAGKQRAPVLRALFGEGRA--TATLLLWISYFFTlIVLYFLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 273 IWLPQMLKAHGMTVAQTGWlsaVPYFF------ATIALLWWAKRVdRRGGAIANLAAGLLIGGVALGVSTHFhqlGPAMV 346
Cdd:PRK11551  241 NWLPSLLVGQGLSRSQAGL---VQIAFniggalGSLLIGALMDRL-RPRRVVLLIYAGILASLAALAAAPSF---AGMLL 313
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 347 GVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKdSYGTFTAGMMGLAI 416
Cdd:PRK11551  314 AGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLL-ALGRSTVGVIGASI 382
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
34-354 1.04e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 56.80  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  34 LALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSF 113
Cdd:cd17321     1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 114 AVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGWRWMFI 193
Cdd:cd17321    81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE------LFGWRWIFL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 194 IeGLPACVVGFLvlkmladrpadarwLSPAERDALqgafdregsssrkekhfgaalrdvrvyilaLISFGFTMGSYGIGI 273
Cdd:cd17321   155 I-NVPIGLVALL--------------LARTFSGAV------------------------------LAAFLLGAALGGLLF 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 274 WLPQMLK-AHGMTVAQTGwLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGP-AMVGVTLA 351
Cdd:cd17321   190 LLPLYLQgVLGYSPLQAG-LALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSvWLLLPGLV 268

                  ...
gi 1589895752 352 LIG 354
Cdd:cd17321   269 LLG 271
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
74-400 1.70e-08

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 56.09  E-value: 1.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  74 FAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAV--GPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYR 151
Cdd:cd17318    66 FYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLER 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 152 TRVLAWFTVSTPLSSLIGAPLSTWLLHLdgvlglAGWRWMFIIEGLPACVVGFLVLkmladrpadarWLSPAerdalqga 231
Cdd:cd17318   146 SRLTSIAYSGSQFGTVIAMPLSGFLCES------LGWPSIFYIFGGLGLLWCLLWF-----------FLVLP-------- 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 232 fdregsssrkekhfgaalrdvrVYILALISFGFTMGSYGIGIWLPQMLK-AHGMTVAQTGWLSAVPYF---FATIALLWW 307
Cdd:cd17318   201 ----------------------VWAIVVAHFGHNWGFYTLLTELPTYMSdVLHFNIKSNGFLSSLPYLamwICSIVGGYL 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 308 AKRVDRRGG-------AIANlAAGLLIGGVALGVSTHF-HQLGPAMVGVTLAlIGTIAGRTIFYTLPARFLSGQAAAGGF 379
Cdd:cd17318   259 ADWLRSRGIlstttvrKLFT-SIGFLGPGVFLIALGYLgSNATLAVVFLTLS-VGLSGACYSGFLVNHLDLAPNYAGTLM 336
                         330       340
                  ....*....|....*....|.
gi 1589895752 380 ALINSIGALGGFAGPYLVGYL 400
Cdd:cd17318   337 GITNTAATIAGIISPLIVGAI 357
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
90-426 4.55e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 54.88  E-value: 4.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  90 RFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIG 169
Cdd:cd17474    60 RFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 170 aPLstwllhLDGVLGLAGWRWMFIIEGLpACVVGFLVLKMLADRPADarwlspaerdalqgafDREGSSSRKEKHFGAAL 249
Cdd:cd17474   140 -PL------LGGLLAAISWRYPFFLLAA-LIPVAFLAILFLLPEPKE----------------KAKSSSATKLRDLKKAL 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 250 RDVRVYILALISFGFTMGSYGIGIWLPQMLKAH-GMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIG 328
Cdd:cd17474   196 RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLY 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 329 GVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFT 408
Cdd:cd17474   276 ALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSA 355
                         330
                  ....*....|....*...
gi 1589895752 409 AGMMGLAIVLGITTLLTL 426
Cdd:cd17474   356 PFLVGAAIALAAAVLLAL 373
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
38-426 6.39e-07

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 51.09  E-value: 6.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  38 YFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWL-------ARIMITWGLMAAA 110
Cdd:cd17345    12 YAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLaiglilsAIINILIGFVPSA 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 111 TSfavgpnSFYVIRLLLGIGeaGFFPGVIF-----FLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldGVLGL 185
Cdd:cd17345    92 TS------SVGLMFILLFLN--GWFQGMGWppsgrTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGL---AIFGD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 186 AGWRWMFIIEGLPACVVGFLVLKMLADRPaDARWLSPAER---DALQGAFDREGSS--SRKEKHFGAALRDVRVYILALI 260
Cdd:cd17345   161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTP-ESEGLPPIEEykgDYPEEADGEEEEQelSAWEIFVKYVLKNKLLWYIAIA 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 261 SFGFTMGSYGIGIWLPQMLK-AHGMTVAQTGW------LSAVPyffATIALLWWAKRVDRRGGAIANLAAGLLIgGVALG 333
Cdd:cd17345   240 NVFVYLVRYGILDWAPTYLSeVKGFSKAQAMWafslfeWAAIP---GTLLAGWLSDKLFKGRRAPTGIIFMILV-IVALI 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 334 VstHFHQLGPAMVGVTLALIGT-IAGRTIFYTLPARFLSGQAAAGGFA-LINSIGALGG-FAGPYLVGYLKDSYGtFTAG 410
Cdd:cd17345   316 V--YWLAPNVLVDLIALIALGFlIYGPVMLIGLQALELVPKKAAGTAAgLTGLFGYLGGsVLATALIGIIVDHFG-WNGG 392
                         410
                  ....*....|....*.
gi 1589895752 411 MMGLAIVLGITTLLTL 426
Cdd:cd17345   393 FIVLLASCILAIIFLA 408
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
33-280 8.18e-07

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 51.08  E-value: 8.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  33 LLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATS 112
Cdd:cd17438     3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 113 FAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGA-------PLSTWLLHLDGVLGL 185
Cdd:cd17438    83 FVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASamawsiiPHYGWGFSMGTNYHF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 186 AGWRWMFIIEGLPaCVVGFLVLKMLADRPA--------DARWLspaerdALQGAFDRE-GSSSRKEKHFGAA-LRDVRVY 255
Cdd:cd17438   163 HSWRVFVIICALP-CIASIIALKFMPESPRfllemgkhDEAWM------ILKNIHDTNmRAKGTPEKVFTVSnIKRKNTL 235
                         250       260
                  ....*....|....*....|....*
gi 1589895752 256 ILALISFGFTMGSYGIGIWLPQMLK 280
Cdd:cd17438   236 FLAVVWFTMAFSYYGLTVWFPDMIR 260
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
34-208 4.88e-06

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 48.53  E-value: 4.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  34 LALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGW-GAGIMFAGYCICEVPSNLAlYRFGARRWLARIMITWGLMAAATS 112
Cdd:TIGR00711   7 LMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWvITSYMLANAISIPLTGWLA-KRFGTRRLFLISTFAFTLGSLLCG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 113 FAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgvlGLAGWRWMF 192
Cdd:TIGR00711  86 VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWII------ENYHWRWIF 159
                         170
                  ....*....|....*....
gi 1589895752 193 IIE---GLPACVVGFLVLK 208
Cdd:TIGR00711 160 LINvpiGIIVVVVAFFILP 178
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
34-354 6.42e-06

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 47.96  E-value: 6.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  34 LALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSF 113
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 114 AVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgvlGLAGWRWMFI 193
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLT------DNLSWRWIFY 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 194 IEgLPACVVGFLVLKMLadrpaDARWLspaerdalqgafdregsssrKEKHFGAALrdvrvyilaLISFGFTMGSYGIGI 273
Cdd:cd17503   155 IN-LPIGILALLLAPLL-----DLRLF--------------------KDRNFTLGL---------LLSFLLGLGLFGAMF 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 274 WLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVALGVSTHF-HQLGPAMVGVTLA 351
Cdd:cd17503   200 LLPLYLQnVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLL-LLAGLLLLALGTLLLAFLtPDTSLWLIILPLF 278

                  ...
gi 1589895752 352 LIG 354
Cdd:cd17503   279 IRG 281
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
33-280 7.34e-06

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 48.25  E-value: 7.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  33 LLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATS 112
Cdd:cd17363     3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 113 FAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGA-------PLSTWLLHLDGVLGL 185
Cdd:cd17363    83 FVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASamawaiiPHYGWGFSMGTAYQF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 186 AGWRWMFIIEGLPaCVVGFLVLKMLADRPA--------DARWLspaerdALQGAFDRE-GSSSRKEKHFGAA-LRDVRVY 255
Cdd:cd17363   163 HSWRVFVIVCALP-SVASVVALTFMPESPRfllevgkhDEAWM------ILKQVHDTNmRAKGHPERVFTVShIKRMNTL 235
                         250       260
                  ....*....|....*....|....*
gi 1589895752 256 ILALISFGFTMGSYGIGIWLPQMLK 280
Cdd:cd17363   236 FLAIVWFTMSFSYYGLTVWFPDMIK 260
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
28-214 1.21e-05

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 47.66  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  28 WRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLM 107
Cdd:TIGR01299 166 WALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFF 245
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 108 AAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGA-------PLSTWLLHLD 180
Cdd:TIGR01299 246 AFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAamawaiiPHYGWSFQMG 325
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1589895752 181 GVLGLAGWRWMFIIEGLPaCVVGFLVLKMLADRP 214
Cdd:TIGR01299 326 SAYQFHSWRVFVIVCAFP-CVFAIGALTFMPESP 358
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
57-390 1.70e-05

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 46.53  E-value: 1.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  57 KDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAVGP-NSFYVIRLLLGIGEAGFF 135
Cdd:TIGR00886  30 DDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSySVLLLIRLFIGIAGGSFA 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 136 PGvIFFLALWFPAQYRTRVLA----WFTVSTPLSSLIGAPLSTWLLHLDGVLGLAGWRWMFII-EGLPACVVGFLVLKML 210
Cdd:TIGR00886 110 SC-MPWISFFFPKKIQGTALGlaagWGNMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIvPAGILLLPALLIFFVG 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 211 ADRPADarwlspaerDALQGAFDREGSSsrkekhfgAALRDVRVYILALIsFGFTMGSY-GIGIWLPQMLK-AHGMTVAQ 288
Cdd:TIGR00886 189 ADTPPG---------KPATGKLSFKEAL--------KVFGNRHTWILALL-YSVTFGSFlGVSSIFAMLFKdQFGLSKVQ 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 289 TGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVT----LALIGTIAGRTIFYT 364
Cdd:TIGR00886 251 AGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVlfvaLFFFAGAGNGSTFAL 330
                         330       340
                  ....*....|....*....|....*.
gi 1589895752 365 LPARFlsGQAAAGGFALINSIGALGG 390
Cdd:TIGR00886 331 VPHIF--RRATGAVSGLIGAIGNLGG 354
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
90-426 2.28e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.43  E-value: 2.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  90 RFGARR-WLARIMITWGLMAAATSFAVGPNS------FYVIRLLLGIGEAGFFPGVIFFLALWFP-AQYRTRVLAWFTVS 161
Cdd:COG2211    76 RWGRRRpWILIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAF 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 162 TPLSSLIGAPLSTWLLHLDGVLGLAGWRWMFIIEGLPACVVGFLVLKMLADRPAdarwlspaerdalqgafdREGSSSRK 241
Cdd:COG2211   156 AGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPV------------------PEEEKVSL 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 242 EKHFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAH-GMTVAQTGWLSA---VPYFFATIALLWWAKRVDRRGGA 317
Cdd:COG2211   218 KESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLAlyfLAALLGAPLWPRLAKRFGKKKAF 297
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 318 IanLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYTL------PARFLSGQAAAG-GFALINSIGALGG 390
Cdd:COG2211   298 I--IGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMladvvdYDEWKTGRRREGlYFGIFTFAIKLGQ 375
                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1589895752 391 FAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:COG2211   376 ALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFL 411
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
247-428 3.16e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.74  E-value: 3.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 247 AALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRG--GAIANLAAG 324
Cdd:COG2814     5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGrrRVLLLGLLL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 325 LLIGGVALGVSTHFHQLgpaMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSY 404
Cdd:COG2814    85 FALGSLLCALAPSLWLL---LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
                         170       180
                  ....*....|....*....|....
gi 1589895752 405 GTFTAGMMGLAIVLGITTLLTLSL 428
Cdd:COG2814   162 GWRWVFLVNAVLALLALLLLLRLL 185
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
57-426 1.09e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.09  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  57 KDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFP 136
Cdd:cd17477    24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 137 GVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWllhldgvLGLAGWRWmFIIEGLPACVVGFLVLKMLADRPAd 216
Cdd:cd17477   104 VSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLAL-------VGTAGALP-FLIAAVLLLLALVPLLLTRRAAPE- 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 217 arwlspaerdalqgafdregSSSRKEKHFGAALRDVRVYILALISFGFTMGS-YGIgiwLPQMLKAHGMTVAQTGWLSAV 295
Cdd:cd17477   175 --------------------IEEAESISLRRLLRIAPLALLGAFVAGFLEGAfYSL---LPLYGLRLGLSVAQAALLLAA 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 296 PYFFATIALL---WWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVgVTLALIGTIagRTIFYTLPARFLSG 372
Cdd:cd17477   232 FVLGGLLLQWplgWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLF-LWGGAAGPL--YTLALALAGDRLPG 308
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1589895752 373 QAAAGGFALINSIGALGGFAGPYLVGYLKDSYGtfTAGMMGLAIVLGITTLLTL 426
Cdd:cd17477   309 DELVAANAALLLLYGLGSVIGPLLAGALMDAFG--PHGLFLFLAAVALLFLLFL 360
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
164-420 2.97e-04

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 42.98  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 164 LSSLIGAPLSTWLLHLdgvlglAGWRWMFIieglpaCVVGFLVLKMLADRPADARWLSPAERDALQGAfdregsssRKEK 243
Cdd:cd17485   139 LGSLLGGGGLLWLYDL------IGWQSLLL------SLAALYLLLLLPVLFLRELELPQQPPASERGA--------ALKA 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 244 HFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGWLSAV--------PYFFATIALLWWAKRVDRRG 315
Cdd:cd17485   199 SLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDRGFSLSQIGLLSGVggslvsiaGSLLGGYLLKRRGRRRLLLL 278
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 316 GAIANLAAGLLIGGVALGVSThfhqLGPAMVGVTLALIGTIAG--RTIFYTLPARFLSGQAAAGGFALINSIGALGGFAG 393
Cdd:cd17485   279 GGLLRLLLLGLYTLLALGGSG----LNWVLLLASLALLHLVGGmiTTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLF 354
                         250       260       270
                  ....*....|....*....|....*....|
gi 1589895752 394 PYLVGYLKDSYG---TFTAGMMGLAIVLGI 420
Cdd:cd17485   355 GSLAGFLADHLGyaaAFLLFAILSALSVLL 384
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
256-418 4.44e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 42.18  E-value: 4.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 256 ILALISFGFTMGSYGIGIWLPQMLkahGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVS 335
Cdd:cd17330   182 VYFLIALAFAGLESVFSLFLKDRF---GFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 336 THFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLA 415
Cdd:cd17330   259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAG 338

                  ...
gi 1589895752 416 IVL 418
Cdd:cd17330   339 LLL 341
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
51-220 4.61e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 42.17  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  51 AALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIG 130
Cdd:cd17359    23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 131 EAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTpLSSLIGAPLSTWLL---HLDGVLGLAGWRWMFIIEGLPACVVGFLVL 207
Cdd:cd17359   103 VGGASALVPMYIAEVAPAEIRGRLVSLNQLMI-VFGQLLAYIVNYLIanaGGADWLGAEGWRWMLGLEAIPAILFLLGML 181
                         170
                  ....*....|...
gi 1589895752 208 KMladrPADARWL 220
Cdd:cd17359   182 FI----PESPRWL 190
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
33-280 5.71e-04

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 42.21  E-value: 5.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  33 LLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATS 112
Cdd:cd17440     3 VLGMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 113 FAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGA-------PLSTWLLHLDGVLGL 185
Cdd:cd17440    83 FVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASamawaiiPHYGWSFSMGSAYQF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 186 AGWRWMFIIEGLPaCVVGFLVLKMLADRPA--------DARWLspaerdALQGAFDRE-GSSSRKEKHFGA-ALRDVRVY 255
Cdd:cd17440   163 HSWRVFVIVCALP-CVSSVVALTFMPESPRfllevgkhDEAWM------ILKQIHDTNmRARGQPEKVFTVnRIKKDNTI 235
                         250       260
                  ....*....|....*....|....*
gi 1589895752 256 ILALISFGFTMGSYGIGIWLPQMLK 280
Cdd:cd17440   236 KLTIVWLTLSFGYYGLSVWFPDVIK 260
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
33-280 6.59e-04

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 41.94  E-value: 6.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  33 LLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATS 112
Cdd:cd17439     3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 113 FAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGA-------PLSTWLLHLDGVLGL 185
Cdd:cd17439    83 FVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASamawaiiPHYGWSFQMGSAYQF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 186 AGWRWMFIIEGLPACvvgfLVLKMLADRPADAR-WLSPAERDALQGAFDREGSSSRKEKHFGAALRDV----RVYILALI 260
Cdd:cd17439   163 HSWRVFVLVCAFPSV----FAIGALTTMPESPRfFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVthikRRITLMMM 238
                         250       260
                  ....*....|....*....|..
gi 1589895752 261 SFGFTM--GSYGIGIWLPQMLK 280
Cdd:cd17439   239 AVWFTMsfSYYGLTVWFPDMIK 260
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
67-202 8.72e-04

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 41.30  E-value: 8.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  67 GWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFA--VGPNSFYVIRLLLGIGEAGFFPGVIFFLAL 144
Cdd:cd17381    68 GWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAadLGAGYLIAVRALEGLGEGVTFPAMHAMWAS 147
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1589895752 145 WFPAQYRTRVLAWFTVSTPLSSLIGAPLS---------TWLLHLDGVLGLAGW-RWMFIIEGLPACVV 202
Cdd:cd17381   148 WAPPLERSRLLTISYAGAQLGTVVSLPLSglicyyldwTYVFYIFGAVGLLWFfLWIWLVMPLWAIVV 215
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
158-426 8.73e-04

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 41.41  E-value: 8.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 158 FTVSTPLSSLIGAPLSTWLLHLDGVlglaGWRWMFIIEGLPACVVGFLVLKMLADRPADArwlspaerdalqgafdregs 237
Cdd:cd17339   126 YTTSMNLGAALASGLSVPLAQALGG----GWRGALAIWALPALLALLIWLPQLRRRKRAA-------------------- 181
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 238 SSRKEKHFGAALRDVRVYILALIsFGFT-MGSYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFF---ATIALLWWAKRVDR 313
Cdd:cd17339   182 AAAAPLTKISVWRSPLAWQVTLF-MGLQsLLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVgipASLLVPILATRLKN 260
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 314 RGGAIANLAAGLLIGGVALGVSTHFHQLgPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFAliNSIGALGGFAG 393
Cdd:cd17339   261 QRPIVVLLAVLFIIGVLGLLFAPTALAL-LWAVLLGLGGGAAFSLALTLISLRSSDPAEAAALSGMA--QSVGYLLAALG 337
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1589895752 394 PYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:cd17339   338 PLLFGVLHDLTGSWTAPLVLLLALTVLQLVAGL 370
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
28-210 1.13e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.02  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  28 WRFIPLLALAYFFNYLDRTSVG-FAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGL 106
Cdd:cd17325   198 DRRLLALFLAIFVLAFAFGALEpFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 107 MAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLlhldgvLGLA 186
Cdd:cd17325   278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL------YDAF 351
                         170       180
                  ....*....|....*....|....
gi 1589895752 187 GWRWMFIIEGLPACVVGFLVLKML 210
Cdd:cd17325   352 GFATPFLAAAALLLLAAVLFLLLR 375
MFS_4 pfam06779
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ...
55-426 1.14e-03

Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.


Pssm-ID: 399632 [Multi-domain]  Cd Length: 365  Bit Score: 40.82  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  55 MNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGAR-RWLARI-MITWGLMAAATSFAVGPNSFYVIRLLLGIGEA 132
Cdd:pfam06779  19 MIAEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGASRlRPALLAgLLATVLLLLAMAATSSFWAVLLIRFLAGVASA 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 133 GFFpgvIFFLALWFP---AQYRTRVLAWFTVSTPLSSLIGApLSTWLLHLDGVLGLAGWrwmfiieglpacvVGFLVLKM 209
Cdd:pfam06779  99 AVM---IFGSSLILGhatAARRAFVGALLFAGVGIGIALSG-LLVPLGLQLGLGGSSLW-------------YGAGVLSA 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 210 LADRPADARWLSPAERDALQGAFdregsssrkekHFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAQT 289
Cdd:pfam06779 162 VLTLAVFPLLPRRAPRHASAPAP-----------AAKPLQRSLPLWILTLAYGLAGFGYIITATFLPAMARDGFGGPAAA 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 290 GWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVALGVSTHFHQLGPAMVGVtLALIGTIAGRTIFYTLPARF 369
Cdd:pfam06779 231 ALFWSLFGLAAALGVLVWLRAAKRWGTRPA-LTAALLIQALGVLLSLLSPSPAGLAVSS-LLFGGTFMAITSLVMQLARE 308
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1589895752 370 LSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:pfam06779 309 LAPPAPRRLLGLMTASFGIGQILGPLLASLLTAATGGLTPALLLAAAALVLAALIVL 365
MFS_1 pfam07690
Major Facilitator Superfamily;
257-426 2.10e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.09  E-value: 2.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 257 LALISFGFTMGSYGIGIWLPQ-MLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVALGVS 335
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV-LLIGLLLFALGLLLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 336 THFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGtFTAGMMGLA 415
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILA 158
                         170
                  ....*....|.
gi 1589895752 416 IVLGITTLLTL 426
Cdd:pfam07690 159 ILSLLAAVLLL 169
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
257-428 2.38e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.10  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 257 LALISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVST 336
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 337 hFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAI 416
Cdd:cd06174    81 -APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
                         170
                  ....*....|..
gi 1589895752 417 VLGITTLLTLSL 428
Cdd:cd06174   160 ALALLAAILLLL 171
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
36-214 2.76e-03

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 39.70  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  36 LAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAV 115
Cdd:cd17488    10 IGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 116 GPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIgAPLSTWLLHLDGvlglaGWRWMFIIE 195
Cdd:cd17488    90 SLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGAL-IPILTGFAALTY-----GWRAGMYVP 163
                         170
                  ....*....|....*....
gi 1589895752 196 GLPACVVGFLVLKMLADRP 214
Cdd:cd17488   164 GIIAILMGIVLCWRLRDRP 182
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
257-423 3.50e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 39.48  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 257 LALISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVA---LG 333
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRL-LLLGLLLLAVStllFA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 334 VSTHFHQLGPAMV--GVTLALIGTIAGRTIFYTLPARFLSGQaaaggFALINSIGALGGFAGPYLVGYLKDSYG-----T 406
Cdd:cd17325    80 FATSYWQLLLARFlqGLASAAVWPAAMALIADIAPPEERGRA-----MGIFSSAIGLGFLIGPLLGGLLADALGyrapfL 154
                         170
                  ....*....|....*..
gi 1589895752 407 FTAGMMGLAIVLGITTL 423
Cdd:cd17325   155 VCAALALLALVLALLLL 171
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
247-431 5.97e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 38.70  E-value: 5.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 247 AALRDVRVYILALISFGFTMGS---YGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAA 323
Cdd:COG2271     2 RAPSRYRWRILALLFLAYFLNYldrSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRV-LAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 324 GLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDS 403
Cdd:COG2271    81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
                         170       180       190
                  ....*....|....*....|....*....|
gi 1589895752 404 YGTFTA--GMMGLAIVLGITTLLTLSLYAF 431
Cdd:COG2271   161 FGWRAAflILGLPGLLLALLRFWLLALAYF 190
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
97-428 7.46e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.37  E-value: 7.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752  97 LARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWL 176
Cdd:cd06173    72 LLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLL 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 177 LhldgvlGLAGWRWMFIIEGLPACVVGFLVLKMLADRPADARWLSPAERDALQGAFDRegsssrkekhfgaALRDVRVYI 256
Cdd:cd06173   152 V------ALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRY-------------LRRSPLLRL 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 257 LALISFGFTMGSYGIGIWLPQMLKAH-GMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGgAIANLAAGLLIGGVALGVS 335
Cdd:cd06173   213 LLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR-RGRLLLIGALLLGLALLVL 291
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 336 THFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAgMMGLA 415
Cdd:cd06173   292 GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV-FLLAG 370
                         330
                  ....*....|...
gi 1589895752 416 IVLGITTLLTLSL 428
Cdd:cd06173   371 ALLLLAALLLLLL 383
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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