|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
28-426 |
9.63e-85 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 263.28 E-value: 9.63e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 28 WRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLM 107
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 108 AAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLlhldgvLGLAG 187
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL------LLLFG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 188 WRWMFIIEGLPACVVGFLVLKMLAdrpadarwlspaerdalqgafdregsssrkekhfgaalrdvRVYILALISFGFTMG 267
Cdd:cd17319 156 WRWAFIIEGLLGLLLAVLWWFYLR-----------------------------------------QVWGLALGYFGINYA 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 268 SYGIGIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDR--RGGAIANLAAGLLIGGVALGVSTHFHQLGPA 344
Cdd:cd17319 195 LYGLLTWLPTYLKqARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTTSPVVA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 345 MVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLL 424
Cdd:cd17319 275 VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALL 354
|
..
gi 1589895752 425 TL 426
Cdd:cd17319 355 VL 356
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
36-428 |
1.06e-77 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 246.86 E-value: 1.06e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 36 LAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAV 115
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 116 GPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGWRWMFIIE 195
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILI------HFSWQWAFIIE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 196 GLPACVVGFLVLKMLADRPADARWLSPAERDALQGAFDRE----GSSSRKEKHFGAALRDVRVYILALISFGFTMGSYGI 271
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEqqgkGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 272 GIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRG------------GAIANLAAGLLIGGVALGVSTHF 338
Cdd:TIGR00893 235 LTWFPTYLVqERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLrrgkslvfarktAIIAGLVLSLLMFATNYVNIPYA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 339 hqlgpAMVGVTLALIGTIAGrTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVL 418
Cdd:TIGR00893 315 -----ALALVALGFFGLGAG-AIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALA 388
|
410
....*....|
gi 1589895752 419 GITTLLTLSL 428
Cdd:TIGR00893 389 LIGALSYLLL 398
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-428 |
1.94e-58 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 195.47 E-value: 1.94e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 20 QQAVRKAAWRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLAR 99
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 100 IMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHl 179
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 180 dgvlgLAGWRWMFIIEGLPACVVGFLvlkmladrpadarwlspaerdalqgafdregsssrkekhfgaalrdvRVYILAL 259
Cdd:COG2271 160 -----AFGWRAAFLILGLPGLLLALL-----------------------------------------------RFWLLAL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 260 ISFGFTMGSYGIGIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRG-GAIANLAAGLLIGGVALGVSTH 337
Cdd:COG2271 188 AYFLVYFALYGFLTWLPTYLVeVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrRRKLVLAIGLLLAALALLLLAL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 338 FHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGtFTAGMMGLAIV 417
Cdd:COG2271 268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAAL 346
|
410
....*....|.
gi 1589895752 418 LGITTLLTLSL 428
Cdd:COG2271 347 ALLAALLALLL 357
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
28-333 |
1.82e-54 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 186.30 E-value: 1.82e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 28 WRFIPLLALAYFFNYLDRTSVGFAALT-MNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGL 106
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 107 MAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHLDGVLGLA 186
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 187 GWRWMFIIEGLPACVVGFLVLKMLADRPADARWLSPAERDAlqgAFDR-------EGSSSRKEKHFGAALRDVRVYILAL 259
Cdd:cd17327 164 GWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKEL---AVERlranqtgKGDQKFKWKQIKEAFKDPRTWLLFL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1589895752 260 ISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALL---WWAKRVDRRGGAIANLAAGLLIGGVALG 333
Cdd:cd17327 241 FFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLiaaLLSDRFKKRGLFAIFACVLALVGSIILL 317
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
25-435 |
1.05e-52 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 181.23 E-value: 1.05e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 25 KAAWRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITW 104
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 105 GLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLlhldgvLG 184
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL------IA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 185 LAGWRWMFIIEGLPACVVGFLVLKMLADRPADARWLSPAERdalqgafdregsssrkeKHFGAALRDVRVYILALISFGF 264
Cdd:COG2223 155 AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASL-----------------RDQLEALRDPRFWLLSLLYFGT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 265 TMGSYGIGIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGP 343
Cdd:COG2223 218 FGSFIGFSSWLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 344 AMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTL 423
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
|
410
....*....|..
gi 1589895752 424 LTLSLYAFNREK 435
Cdd:COG2223 378 LTLLLYRRPRRA 389
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-390 |
1.83e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 109.29 E-value: 1.83e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 21 QAVRKAAWRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARI 100
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 101 MITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHld 180
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 181 gvlgLAGWRWMFIIEGLPACVVGFLVLKMLADRPADARwlspaerdalqgafdregssSRKEKHFGAALRDVRVYILALI 260
Cdd:COG2814 160 ----LFGWRWVFLVNAVLALLALLLLLRLLPESRPAAR--------------------ARLRGSLRELLRRPRLLLLLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 261 SFGFTMGSYGIGIWLPQMLKA-HGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVALGVSTHFH 339
Cdd:COG2814 216 AFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL-LLIGLLLLALGLLLLALAG 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1589895752 340 QLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGG 390
Cdd:COG2814 295 SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
34-394 |
4.27e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.89 E-value: 4.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 34 LALAYFFNYLDRTSVGFA-ALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATS 112
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 113 FAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGWRWMF 192
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS------LFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 193 IIEGLPACVVGFLVLkmLADRPADARWLSPAERDALQGAFDREgsssrkekhfgaALRDVRVYILALISFGFTMGSYGIG 272
Cdd:pfam07690 155 LILAILSLLAAVLLL--LPRPPPESKRPKPAEEARLSLIVAWK------------ALLRDPVLWLLLALLLFGFAFFGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 273 IWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLAL 352
Cdd:pfam07690 221 TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLL 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1589895752 353 IGTIAG--RTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGP 394
Cdd:pfam07690 301 LGFGFGlvFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-426 |
2.98e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 103.28 E-value: 2.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 34 LALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSF 113
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 114 AVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgVLGLAGWRWMFI 193
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA----SSLGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 194 IEGLPACVVGFLVLKMLADRPADARwlspaerdalqgAFDREGSSSRKEKHFGAALRDVRVYILALISFGFTMGSYGIGI 273
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESAR------------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFST 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 274 WLPQMLKAHGM-TVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLAL 352
Cdd:cd06174 225 LLPLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1589895752 353 IGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:cd06174 305 FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
14-428 |
4.75e-24 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 103.03 E-value: 4.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 14 NASSIEQQAVRKAAWRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGA 93
Cdd:COG2807 3 TTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 94 RRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQyRTRVLAWFTVSTPLSSLIGAPLS 173
Cdd:COG2807 83 ERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 174 TWLLHLdgvlglAGWRWMFIIEGLPACVVGFLVLKMLADRPADARwlspaerdalqgafdregsSSRKEKHFGAALRDVR 253
Cdd:COG2807 162 VPLAAA------LGWRGALAVWALLALLALLLWLPLLRRRPAAAA-------------------AAPAAASLRSLWRSPL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 254 VYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFF---ATIALLWWAKRVDRRGGAIANLAAGLLIGGV 330
Cdd:COG2807 217 AWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAgipGSLLVPLLADRLGDRRPLLLLLGLLGLAGLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 331 ALGvsthFHQLGPAMVGVTLALIGTIAGRTIFYTLPA-RFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTA 409
Cdd:COG2807 297 GLL----LAPGSLPWLWAVLLGLGQGGLFPLALTLIGlRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTA 372
|
410
....*....|....*....
gi 1589895752 410 GMMGLAIVLGITTLLTLSL 428
Cdd:COG2807 373 ALLLLAALAVLMLVAGLLA 391
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
31-430 |
6.86e-21 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 93.39 E-value: 6.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 31 IPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAA 110
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 111 TSFAVGPNSFYVI--RLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGW 188
Cdd:cd17380 81 TPLLAYSSLPLLIlsRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE------YYGW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 189 RWMFIIEGLPACVVGFLVLKMLAdrpadARWlspaerdalqgafdregsssrkekhfgaalrdvrvyilALISFGFTM-- 266
Cdd:cd17380 155 PSVFYFFGLLGLLWALVWLIYLP-----PVW--------------------------------------AIIVAHFCMnw 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 267 GSYGIGIWLPQMLKAHGMTVAQTGWLSAVPY---FFATIALLWWAKRVDRRGGAIANL-----AAGLLIGGVALGVSTHF 338
Cdd:cd17380 192 GFYILLSWLPTYFHEVLVPLAKGWVFNVVPWlvmFPSSNVAGWLADHLISRGWTVTSVrklmqSIGFLGPALFLLLLSHT 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 339 HQLGPAMVGVTLALIGTIAGRTIFYTLPARfLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAgMMGLAIVL 418
Cdd:cd17380 272 DSFSLALLCMSVALGLSAFSSSGVLVNHQD-IAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSL-VFVLAAVV 349
|
410
....*....|..
gi 1589895752 419 GITTLLTLSLYA 430
Cdd:cd17380 350 NLVGAVVFLLFG 361
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
16-400 |
2.58e-19 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 89.34 E-value: 2.58e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 16 SSIEQQAVRKAAWRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARR 95
Cdd:TIGR00895 4 NNIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 96 WLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTW 175
Cdd:TIGR00895 84 VLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 176 LlhldgvLGLAGWRWMFIIEGLPACVVGFLVLKMLadrPADARWL---------------SPAERDALQGAFDREGSSSR 240
Cdd:TIGR00895 164 L------IPVFGWRSLFYVGGIAPLLLLLLLMRFL---PESIDFLvskrpetvrrivnaiAPQMQAEAQSALPEQKSTQG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 241 KEKH-FGAALRDVRVYILALISFGFTMGS---YGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGg 316
Cdd:TIGR00895 235 TKRSvFKALFQGKTARITVLLWLLYFMLLvgvYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLG- 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 317 aiANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIG--TIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGP 394
Cdd:TIGR00895 314 --PRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGffVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGP 391
|
....*.
gi 1589895752 395 YLVGYL 400
Cdd:TIGR00895 392 ILAGYL 397
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
57-429 |
1.27e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.78 E-value: 1.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 57 KDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRwlariMITWGLMAAATS---FAVGPN--SFYVIRLLLGIGE 131
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKR-----LLLLGLLLLAVStllFAFATSywQLLLARFLQGLAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 132 AGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgvlGLAGWRWMFIIEGLPACVVGFLVLKMLA 211
Cdd:cd17325 99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA------DALGYRAPFLVCAALALLALVLALLLLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 212 DRPADARwlspaerdalqgafDREGSSSRKEKHFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAH-GMTVAQTG 290
Cdd:cd17325 173 EPRPPPN--------------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 291 WL---SAVPYFFATIALLWWAKRVDRRGgaiaNLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYTLPA 367
Cdd:cd17325 239 LLfgaQGLASALSQPPAGKLSDRIGRKP----LILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1589895752 368 RFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGtFTAGMMGLAIVLGITTLLTLSLY 429
Cdd:cd17325 315 DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLLR 375
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
36-405 |
2.04e-17 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 83.58 E-value: 2.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 36 LAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAV 115
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 116 GPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLStwllhLDGVLGLAGWRWMFIIE 195
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLV-----LFGIAELYSWHWVFIVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 196 GLPACVVGFLVLKMLADRPADARwLSPAER---DALQGAFDREGSSSRKEKHFGAALRDVRVYILALISFGFTMG-SYGI 271
Cdd:TIGR00881 157 GIIAIIVSLICFLLLRDSPQSCG-LPPAEEmpnEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVvRTGI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 272 GIWLPQ-MLKAHGMTVAQTGWLSAVPYFFATIALLWWA----KRVDRRGGAIANLAAGLLIggVALGVSTHFHQLGPAMV 346
Cdd:TIGR00881 236 LDWSPLyLTQEKGFSKEKASWAFTLYELGGLVGTLLAGwlsdKLFNGRRGPLAVFFMALII--VSLLVYWLNPAANPLMD 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1589895752 347 GVTLALIGTIAGRTIFYT--LPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYG 405
Cdd:TIGR00881 314 LICLFALGFLVYGPQMLIgvIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
32-429 |
1.32e-16 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 81.13 E-value: 1.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 32 PLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGaRRWLARIMIT-WGLMAAA 110
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN-RKWILAVGILiWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 111 TSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHLDGvlglaGWRW 190
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG-----GWRW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 191 MFIIEGLPACVVGFLVLKMLADRPadarwlspaerdalQGAFDREGSSSRKEKHFGAALRDV-RVYILALISFGFTMGSY 269
Cdd:cd17328 156 AFRVTGVLGVLLAILLLLFVREPP--------------RGAAEGGVMAKSTATSFLADLKALaKNPSFILSTLGFTAVSF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 270 GIG---IWLPQ-MLKAHGMTVAQT-------GWLSAVPYFFATIALLWWAKRVDRRggaiaNLAAGLLIGGVALGVSTHF 338
Cdd:cd17328 222 VTGalaFWAPTfFLRAFGVGDLSSadvglifGAITCIAGVLGVLLGGILADRLRRK-----TPRADPLVCAVGLLAAAPF 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 339 hqLGPAMVGV---TLALIGTIAGRTIFYTL--------------PARFLSGQAAaggFALINSIgaLGGFAGPYLVGYLK 401
Cdd:cd17328 297 --LFLALVLAlsnLLLAWVLLFLGEFLLSLnwapvfaillyvviPTRRSTASAI---QILLSHL--LGDAGSPYLIGLIS 369
|
410 420 430
....*....|....*....|....*....|....*.
gi 1589895752 402 DSYGT--------FTAGMMGLAIVLGITTLLTLSLY 429
Cdd:cd17328 370 DLLRQnkdsplaeAASLQYALLLCSFVLVLGGFFFL 405
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
33-426 |
7.28e-16 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 78.41 E-value: 7.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 33 LLALAYFFNYLDRTSVGFAALTM--NKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAA 110
Cdd:cd17316 3 LAGLGWFFDAYDFFLIGFVAPVLaaEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 111 TSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHLDGvlGLAGWRW 190
Cdd:cd17316 83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLS--GDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 191 MFIIEGLPACVVGFLVLKMLadrpadarwlspaerdalqgafdregsssrkekhfgaalrdvrvyILALISFGFTMGSYG 270
Cdd:cd17316 161 LFLIGALPALLALLLRRRTL---------------------------------------------LLILLWFFISFGYYG 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 271 IGIWLPQMLKAH-GMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVT 349
Cdd:cd17316 196 LTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLL 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1589895752 350 LALIGTIAGRT-IFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:cd17316 276 FILSFFVGGVWgALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
31-430 |
1.52e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 77.63 E-value: 1.52e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 31 IPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAA 110
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 111 TSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgvlGLAGWRW 190
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALI------PAFGWRS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 191 MFIIEGLPACVVGFLVLKMLAdrpadarwlspaerdalqgafdregsssrkekhfgaalrdvrvyiLALISFGFTMGSYG 270
Cdd:cd17365 155 VFLLGGVPPLILLPLLRGTLL---------------------------------------------LWVTFFMGLLLVYL 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 271 IGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTL 350
Cdd:cd17365 190 LNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFL 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 351 ALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTLSLYA 430
Cdd:cd17365 270 AGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLRL 349
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
52-425 |
7.61e-14 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 72.67 E-value: 7.61e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 52 ALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMI-----TWGLMAAATSFAVgpnsFYVIRLL 126
Cdd:cd17341 22 GPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLlllipLLALALAVSSYWG----LLVLGFL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 127 LGIGEAGFFPGvIFFLALWFPAQYRTRVL----AWFTVSTPLSSLIGAPLSTWLLHLDGVLGlagWRWMFIIEGLPACVV 202
Cdd:cd17341 98 LGFAGANFASG-QPWASFWFPKEKIGGAAggiaGAGNMGVAVSQLLAPLIAGAIVFDGGFVG---WRNAFFVPGILLAIA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 203 GFLVLKMLADRPADARWLSPAERDALqgafdregsssrkekhfgAALRDVRVYILALIsFGFTMGSY-GIGIWLPQMLKA 281
Cdd:cd17341 174 AVLVLLFGDDLPTGKASALEFLKVQL------------------AVLKNYRTWILSLL-YGVTFGSFvGFSNVLPTYFKT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 282 H-GMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALI------G 354
Cdd:cd17341 235 RfGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFValglgaG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1589895752 355 TIAGRTiFYTLPARFLSGQAAAGGFalINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLT 425
Cdd:cd17341 315 AGNGSV-FRMVPFIFRRELGAVTGL--VGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLV 382
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
24-429 |
4.21e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 70.27 E-value: 4.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 24 RKAAWRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMIT 103
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 104 WGLMAAATSFAVGPNSFYVIRLLLGIGeAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHLDGVl 183
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLG-LGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLS- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 184 glAGWRWMFIIEGLPACVVGFLVLKMLADRPADarwlspaerdalqgafdREGSSSRKEKHFGAALRDVRVYILALISFG 263
Cdd:COG0738 161 --LSWHLPYLILAVLLLLLALLFLRSKLPEIEE-----------------EEEEAAGSAASLKSLLKNPRLLLGGLAIFL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 264 FTMGSYGIGIWLPQMLK-AHGMTVAQTGWLSAVPYFFATIALL---WWAKRVDRRGGaianLAAGLLIGGVALGVSTHFH 339
Cdd:COG0738 222 YVGAEGAIGDWLPLYLKdVLGLSEATAALGLSLFWGGMTIGRFlggFLLKRFGPVRL----LRLSALLAAVGLLLALLAP 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 340 QLGPAMVGVTLALIGTIAGRTIFYTLPARFLsGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGtFTAGMMGLAIVLG 419
Cdd:COG0738 298 GPWLALIGLALVGLGLSLMFPTIFSLALDGL-GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLVPLVCYL 375
|
410
....*....|
gi 1589895752 420 ITTLLTLSLY 429
Cdd:COG0738 376 LILLLALALK 385
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
90-426 |
5.84e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 69.91 E-value: 5.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 90 RFGARRWLARIMITWGLMAAATSFAvgpNSFYVI---RLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSS 166
Cdd:cd17473 61 RFGRKRLLIAGLLLYGIGGVAGLFL---DSLYALlasRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 167 LIGAPLStwllhldGVLGLAGWRWMFIIEGLpACVVGFLVLKMLADRPadarwlspaerdalqgafDREGSSSRKEKHFG 246
Cdd:cd17473 138 VVFLLLG-------GALAEIGWRAPFLVYLL-ALPVLILVLLFLPEPA------------------RKSKSAASPGAATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 247 AALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHG-MTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGL 325
Cdd:cd17473 192 AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 326 LiggVALGVSTHFHQLGPAMVGVTLALIGTIAGRTI--FYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDS 403
Cdd:cd17473 272 L---MALGFLLLALASGLWVVLLGAILAGLGFGLLLptLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNL 348
|
330 340
....*....|....*....|...
gi 1589895752 404 YGTFTAGMMGLAIVLGITTLLTL 426
Cdd:cd17473 349 TGGLSGAFLILGVLALVLAIVLL 371
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
59-420 |
7.63e-13 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 69.61 E-value: 7.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 59 LGLTATQFGWGAGIMFAGYcicevpsnlALYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGV 138
Cdd:cd17355 42 LAFTVGLLAFGLAQPFVGR---------LLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 139 IF-FLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGWRWMFIIEGLPACVVGFLVLKMLADRPADa 217
Cdd:cd17355 113 AFaTVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIE------AFGWRTALLVLALLALLVLVPVLLLLRRRPAD- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 218 rwlsPAERDALQGAFDREGSSSRkekhfgAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGW---LSA 294
Cdd:cd17355 186 ----LALRAYDDASPASPGSTLK------EALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAValaLIG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 295 VPYFFATIALLWWAKRVDRRggaiANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFY-TLPARFLSGQ 373
Cdd:cd17355 256 LFNIVGRLLSGWLGDRYSPR----RLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTaALAARYFGAR 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1589895752 374 AAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAgMMGLAIVLGI 420
Cdd:cd17355 332 SYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTA-AWALAVALGL 377
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
28-305 |
9.02e-13 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 68.68 E-value: 9.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 28 WRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLM 107
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 108 AAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAG 187
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA------ALG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 188 WRWMFIIEGLPACVVGFLVLKMLADRPADARWLSPAERDALQGAFDREGSSSRKEKHFGAALRDVRVYILALISFGFTMG 267
Cdd:COG0477 167 WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL 246
|
250 260 270
....*....|....*....|....*....|....*...
gi 1589895752 268 SYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALL 305
Cdd:COG0477 247 LLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLL 284
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
57-418 |
2.16e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 67.96 E-value: 2.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 57 KDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFP 136
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 137 GVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLlhldgvLGLAGWRWMFIIEGLPACVVGFLVLKMLADRPAD 216
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL------GQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 217 ARwlspaerdalqgafdregSSSRKEKHFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLK--AHGMTVAQTGWLSA 294
Cdd:cd17324 181 KP------------------GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTdvPGFSSSAIIGLLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 295 vpYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYTLPARfLSGQA 374
Cdd:cd17324 243 --FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR-LAPEA 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1589895752 375 AAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVL 418
Cdd:cd17324 320 RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLL 363
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
55-426 |
3.42e-12 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 67.33 E-value: 3.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 55 MNKDLGLTATQFGWGAGIMFAGYCICEVpsnlaLYRFGARRWLARIMITWGLMA-----AATSFAVGPNSFYVIRLLLGI 129
Cdd:cd06180 25 MLAELGLSYAQAGWIATANYAGYLVGAL-----LASFLRRRGRARRLIRGGLLLtvlllAAMALTSGFAALLALRFLAGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 130 GEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAplstwLLHLDGVLGLAGWRWMFIIEGLPACVVGFLVLKM 209
Cdd:cd06180 100 ASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSG-----LLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 210 LADRPADARWLSPAERdalqgafdregsssrkekhfgAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAQT 289
Cdd:cd06180 175 LRRGPSAPTEASAAES---------------------APGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 290 GWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVALGVSTHFHQLGPAMVGVTLaLIGTIAGRTIFYTLPARF 369
Cdd:cd06180 234 GLLWSLFGLAAVPSCFLWGALSDRWGTRRA-LAANLLVQAVGVLLPLLSPGPAGLVLSAVL-FGGTFMAITALVMALARE 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1589895752 370 LSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:cd06180 312 LAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLAL 368
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
62-428 |
1.27e-11 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 65.79 E-value: 1.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 62 TATQFGWGAGIMFAGYCIcevpsnlalYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFF 141
Cdd:cd17371 41 TVTLAGGAIGGILGGILA---------DRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAAL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 142 LALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHLdgVLGLAGWRWMFIIEGLPACVVGFLVLKMladrPADARWLs 221
Cdd:cd17371 112 MAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPL--LPPEIAWRVLFLLGALPALLVLFIRRFV----KEPPQWQ- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 222 paerdALQGAFDREGSSSRKEKHFGAALRdvRVYILA-LISFGFTMGSYGIGIWLPQMLK-AHGMTVAQTGWLSAVPY-- 297
Cdd:cd17371 185 -----AARAARRHFADRPSLRELFSPPLL--RTTLLAsLLATGALGGYYGITTWLPSYLTgERGLSFEGSAGYLVVTIlg 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 298 -FFATIALLWWAKRVDRRggaiANLAAGLLIGGVALGVSTHFHqLGPAMVGVTLALIGTIAG---RTIFYTLPARFLSGQ 373
Cdd:cd17371 258 gFLGYLAGGFLADRIGRR----NNFALFALGSAISILLYFFLP-LSPTLILILGFPLGFFASgpfSGMGAYLTELFPTAV 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1589895752 374 AAAGGFALINsIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTLSL 428
Cdd:cd17371 333 RATAQGFCYN-VGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLL 386
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
47-426 |
2.00e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 65.34 E-value: 2.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 47 SVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLL 126
Cdd:cd17475 14 GIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 127 LGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLstwllhLDGVLGLAGWRWMFIIEGLPACVVGFLV 206
Cdd:cd17475 94 VGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAAL------LPPLALHYGWRAAFVVAGLVSILAAVLF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 207 LkmladrpadaRWLSPAERDALQGAFDREGSSSRKEKHFGAALRDVRVYILALISFGFTMGSYgigiWLPQMLKAHGMTV 286
Cdd:cd17475 168 W----------LFYREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTF----LLLFLHDHLGLSV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 287 AQTGWLSAVPYFFATIALLWWAKRVDRRGG--------AIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAg 358
Cdd:cd17475 234 VAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrrpvlvITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNG- 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1589895752 359 rtIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:cd17475 313 --LYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
50-429 |
1.31e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 62.63 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 50 FAALTMNKDLGLTATQfgwgAGIMFAGYCICEVPSNL---ALY-RFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRL 125
Cdd:cd17329 21 FMAIYLHQQLGLSASI----VGLVLALSAVAGIVASLiggRLAdRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 126 LLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgvlgLAGWRWMFIIEGLpACVVGFL 205
Cdd:cd17329 97 LTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-------LYSFRLLFLAAAV-LFLLAAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 206 VLkmladrpadARWLSPAERDALQGAFDREGSSSRkekhfgAALRDVRVYILALISFGFTMGSYGIGIWLPQMLK-AHGM 284
Cdd:cd17329 169 VL---------LFLLPETRPKRRAAEKTEILRGYK------IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVeILGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 285 TVAQTGWLSAVPyFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYT 364
Cdd:cd17329 234 GESLLGLLLALN-ALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQT 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1589895752 365 LPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGtFTAGMMGLAIVLGITTLLTLSLY 429
Cdd:cd17329 313 LVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG-PGLPWLILAALGLIAAALLLGLQ 376
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
122-400 |
7.51e-10 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 60.53 E-value: 7.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 122 VIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHLDGvlglaGWRWMFIIEGLPACV 201
Cdd:TIGR00894 136 FCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWG-----GWPMIFYVFGIVGCA 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 202 VGFLVLKMLADRPADARWLSPAERDALQGAFDREGSSSRKEKHFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKA 281
Cdd:TIGR00894 211 WSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISW 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 282 H-GMTVAQTGWLSAVPYFFATI------ALLWW--AKRVDRRGGA--IANLAAGLLIGgvALGVSTHFhqLGPAMVGVTL 350
Cdd:TIGR00894 291 VlRVSGKENGLLSSLPYLFAWLcsifagYLADFlkSSKTLSLTAArkIFNGIGGLGPG--IFAYALPY--LSAAFYLTII 366
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1589895752 351 ALigTIAGRTIFYTLPARFLSGQAAAGGFA-LINSIGALGGFAGPYLVGYL 400
Cdd:TIGR00894 367 IL--TLANAVSSGPLAGVLINSLDLAPRFLgFIKGITGLPGFIGGLIASTL 415
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
57-433 |
1.74e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.14 E-value: 1.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 57 KDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFP 136
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 137 GVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGWRWMFIIEGLpACVVGFLVLKMLADRPAD 216
Cdd:cd17489 104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ------HLGFAVLFIVAAV-LALLALLLVFLVKDPPPV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 217 ArwlspaerdalqgafdreGSSSRKEKHFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAqtGWLSAVP 296
Cdd:cd17489 177 A------------------AEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNA--GLFFTVY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 297 YFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAA 376
Cdd:cd17489 237 AIALLLSRPFSGKLSDRKGPKTV-IIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRG 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1589895752 377 GGFALINSIGALGGFAGPYLVGYLKDSYGtfTAGMMGLAIVLgitTLLTLSLYAFNR 433
Cdd:cd17489 316 AANGTFFIFFDLGIGLGGLLLGLVAELFG--YRAMFLLAAVV---VLLALVLYIFLL 367
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
28-424 |
5.77e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 57.67 E-value: 5.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 28 WRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLM 107
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 108 AAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgvlGLAG 187
Cdd:cd17312 82 NIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLA------SYYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 188 WRWMFIIEGLPACVVGFLVLKMLADRPAdarwlspaerdalqgafdregsssrkekhfgaalrdvRVYILALISFGFTMG 267
Cdd:cd17312 156 WRAAFLVPGIVGLVVAIILFFFLRDSPP-------------------------------------YVWVLSLAYAFVYIV 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 268 SYGIGIWLPQMLKA-HGMTVAQTGWLS---AVPYFFATIALLWWAKRVD--RRGGAIANLAAGLLIGGVALGVSTHfhql 341
Cdd:cd17312 199 RYACLDWGPLYLYEvKGYSLIDAGWFSslyEVGGIAGTILAGLLSDKLFggRRAPIAVIYMLLMTLSLALFWFFPH---- 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 342 GPAMVGVTLALIG-TIAGRTIFYTL--PARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVL 418
Cdd:cd17312 275 NKLLSIVLLFLIGfFVGGPINLIGGaaAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAAL 354
|
....*.
gi 1589895752 419 GITTLL 424
Cdd:cd17312 355 LSVLLL 360
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
43-416 |
6.00e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 57.66 E-value: 6.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 43 LDRTSVGFAALTMNKDLGLTATQFGW--GAGI-------MFAGYcicevpsnLAlYRFGARRWLARIMITWGLMAAATSF 113
Cdd:PRK11551 29 LDLQSAGVAAPRMAQEFGLDVAQMGWafSAGIlgllpgaLLGGR--------LA-DRIGRKRILIVSVALFGLFSLATAQ 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 114 AVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLlhldgvLGLAGWRWMFI 193
Cdd:PRK11551 100 AWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLA------AGDAAWRHIFY 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 194 IEGlpacVVGFLVLKMLadrpadARWLsPAERDALQGAFDREGSSSRKEKHFGAALRdvRVYILALISFGFT-MGSYGIG 272
Cdd:PRK11551 174 VGG----VGPLLLVPLL------MRWL-PESRAFAQAAGAGKQRAPVLRALFGEGRA--TATLLLWISYFFTlIVLYFLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 273 IWLPQMLKAHGMTVAQTGWlsaVPYFF------ATIALLWWAKRVdRRGGAIANLAAGLLIGGVALGVSTHFhqlGPAMV 346
Cdd:PRK11551 241 NWLPSLLVGQGLSRSQAGL---VQIAFniggalGSLLIGALMDRL-RPRRVVLLIYAGILASLAALAAAPSF---AGMLL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 347 GVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKdSYGTFTAGMMGLAI 416
Cdd:PRK11551 314 AGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLL-ALGRSTVGVIGASI 382
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
34-354 |
1.04e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.80 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 34 LALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSF 113
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 114 AVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLHldgvlgLAGWRWMFI 193
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE------LFGWRWIFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 194 IeGLPACVVGFLvlkmladrpadarwLSPAERDALqgafdregsssrkekhfgaalrdvrvyilaLISFGFTMGSYGIGI 273
Cdd:cd17321 155 I-NVPIGLVALL--------------LARTFSGAV------------------------------LAAFLLGAALGGLLF 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 274 WLPQMLK-AHGMTVAQTGwLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGP-AMVGVTLA 351
Cdd:cd17321 190 LLPLYLQgVLGYSPLQAG-LALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSvWLLLPGLV 268
|
...
gi 1589895752 352 LIG 354
Cdd:cd17321 269 LLG 271
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
74-400 |
1.70e-08 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 56.09 E-value: 1.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 74 FAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAV--GPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYR 151
Cdd:cd17318 66 FYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLER 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 152 TRVLAWFTVSTPLSSLIGAPLSTWLLHLdgvlglAGWRWMFIIEGLPACVVGFLVLkmladrpadarWLSPAerdalqga 231
Cdd:cd17318 146 SRLTSIAYSGSQFGTVIAMPLSGFLCES------LGWPSIFYIFGGLGLLWCLLWF-----------FLVLP-------- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 232 fdregsssrkekhfgaalrdvrVYILALISFGFTMGSYGIGIWLPQMLK-AHGMTVAQTGWLSAVPYF---FATIALLWW 307
Cdd:cd17318 201 ----------------------VWAIVVAHFGHNWGFYTLLTELPTYMSdVLHFNIKSNGFLSSLPYLamwICSIVGGYL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 308 AKRVDRRGG-------AIANlAAGLLIGGVALGVSTHF-HQLGPAMVGVTLAlIGTIAGRTIFYTLPARFLSGQAAAGGF 379
Cdd:cd17318 259 ADWLRSRGIlstttvrKLFT-SIGFLGPGVFLIALGYLgSNATLAVVFLTLS-VGLSGACYSGFLVNHLDLAPNYAGTLM 336
|
330 340
....*....|....*....|.
gi 1589895752 380 ALINSIGALGGFAGPYLVGYL 400
Cdd:cd17318 337 GITNTAATIAGIISPLIVGAI 357
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
90-426 |
4.55e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.88 E-value: 4.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 90 RFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIG 169
Cdd:cd17474 60 RFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 170 aPLstwllhLDGVLGLAGWRWMFIIEGLpACVVGFLVLKMLADRPADarwlspaerdalqgafDREGSSSRKEKHFGAAL 249
Cdd:cd17474 140 -PL------LGGLLAAISWRYPFFLLAA-LIPVAFLAILFLLPEPKE----------------KAKSSSATKLRDLKKAL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 250 RDVRVYILALISFGFTMGSYGIGIWLPQMLKAH-GMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIG 328
Cdd:cd17474 196 RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLY 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 329 GVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFT 408
Cdd:cd17474 276 ALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSA 355
|
330
....*....|....*...
gi 1589895752 409 AGMMGLAIVLGITTLLTL 426
Cdd:cd17474 356 PFLVGAAIALAAAVLLAL 373
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
38-426 |
6.39e-07 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 51.09 E-value: 6.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 38 YFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWL-------ARIMITWGLMAAA 110
Cdd:cd17345 12 YAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLaiglilsAIINILIGFVPSA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 111 TSfavgpnSFYVIRLLLGIGeaGFFPGVIF-----FLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldGVLGL 185
Cdd:cd17345 92 TS------SVGLMFILLFLN--GWFQGMGWppsgrTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGL---AIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 186 AGWRWMFIIEGLPACVVGFLVLKMLADRPaDARWLSPAER---DALQGAFDREGSS--SRKEKHFGAALRDVRVYILALI 260
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTP-ESEGLPPIEEykgDYPEEADGEEEEQelSAWEIFVKYVLKNKLLWYIAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 261 SFGFTMGSYGIGIWLPQMLK-AHGMTVAQTGW------LSAVPyffATIALLWWAKRVDRRGGAIANLAAGLLIgGVALG 333
Cdd:cd17345 240 NVFVYLVRYGILDWAPTYLSeVKGFSKAQAMWafslfeWAAIP---GTLLAGWLSDKLFKGRRAPTGIIFMILV-IVALI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 334 VstHFHQLGPAMVGVTLALIGT-IAGRTIFYTLPARFLSGQAAAGGFA-LINSIGALGG-FAGPYLVGYLKDSYGtFTAG 410
Cdd:cd17345 316 V--YWLAPNVLVDLIALIALGFlIYGPVMLIGLQALELVPKKAAGTAAgLTGLFGYLGGsVLATALIGIIVDHFG-WNGG 392
|
410
....*....|....*.
gi 1589895752 411 MMGLAIVLGITTLLTL 426
Cdd:cd17345 393 FIVLLASCILAIIFLA 408
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
33-280 |
8.18e-07 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 51.08 E-value: 8.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 33 LLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATS 112
Cdd:cd17438 3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 113 FAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGA-------PLSTWLLHLDGVLGL 185
Cdd:cd17438 83 FVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASamawsiiPHYGWGFSMGTNYHF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 186 AGWRWMFIIEGLPaCVVGFLVLKMLADRPA--------DARWLspaerdALQGAFDRE-GSSSRKEKHFGAA-LRDVRVY 255
Cdd:cd17438 163 HSWRVFVIICALP-CIASIIALKFMPESPRfllemgkhDEAWM------ILKNIHDTNmRAKGTPEKVFTVSnIKRKNTL 235
|
250 260
....*....|....*....|....*
gi 1589895752 256 ILALISFGFTMGSYGIGIWLPQMLK 280
Cdd:cd17438 236 FLAVVWFTMAFSYYGLTVWFPDMIR 260
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
34-208 |
4.88e-06 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 48.53 E-value: 4.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 34 LALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGW-GAGIMFAGYCICEVPSNLAlYRFGARRWLARIMITWGLMAAATS 112
Cdd:TIGR00711 7 LMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWvITSYMLANAISIPLTGWLA-KRFGTRRLFLISTFAFTLGSLLCG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 113 FAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgvlGLAGWRWMF 192
Cdd:TIGR00711 86 VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWII------ENYHWRWIF 159
|
170
....*....|....*....
gi 1589895752 193 IIE---GLPACVVGFLVLK 208
Cdd:TIGR00711 160 LINvpiGIIVVVVAFFILP 178
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
34-354 |
6.42e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.96 E-value: 6.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 34 LALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSF 113
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 114 AVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLLhldgvlGLAGWRWMFI 193
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLT------DNLSWRWIFY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 194 IEgLPACVVGFLVLKMLadrpaDARWLspaerdalqgafdregsssrKEKHFGAALrdvrvyilaLISFGFTMGSYGIGI 273
Cdd:cd17503 155 IN-LPIGILALLLAPLL-----DLRLF--------------------KDRNFTLGL---------LLSFLLGLGLFGAMF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 274 WLPQMLK-AHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVALGVSTHF-HQLGPAMVGVTLA 351
Cdd:cd17503 200 LLPLYLQnVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLL-LLAGLLLLALGTLLLAFLtPDTSLWLIILPLF 278
|
...
gi 1589895752 352 LIG 354
Cdd:cd17503 279 IRG 281
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
33-280 |
7.34e-06 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 48.25 E-value: 7.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 33 LLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATS 112
Cdd:cd17363 3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 113 FAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGA-------PLSTWLLHLDGVLGL 185
Cdd:cd17363 83 FVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASamawaiiPHYGWGFSMGTAYQF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 186 AGWRWMFIIEGLPaCVVGFLVLKMLADRPA--------DARWLspaerdALQGAFDRE-GSSSRKEKHFGAA-LRDVRVY 255
Cdd:cd17363 163 HSWRVFVIVCALP-SVASVVALTFMPESPRfllevgkhDEAWM------ILKQVHDTNmRAKGHPERVFTVShIKRMNTL 235
|
250 260
....*....|....*....|....*
gi 1589895752 256 ILALISFGFTMGSYGIGIWLPQMLK 280
Cdd:cd17363 236 FLAIVWFTMSFSYYGLTVWFPDMIK 260
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
28-214 |
1.21e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 47.66 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 28 WRFIPLLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLM 107
Cdd:TIGR01299 166 WALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFF 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 108 AAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGA-------PLSTWLLHLD 180
Cdd:TIGR01299 246 AFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAamawaiiPHYGWSFQMG 325
|
170 180 190
....*....|....*....|....*....|....
gi 1589895752 181 GVLGLAGWRWMFIIEGLPaCVVGFLVLKMLADRP 214
Cdd:TIGR01299 326 SAYQFHSWRVFVIVCAFP-CVFAIGALTFMPESP 358
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
57-390 |
1.70e-05 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 46.53 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 57 KDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAVGP-NSFYVIRLLLGIGEAGFF 135
Cdd:TIGR00886 30 DDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSySVLLLIRLFIGIAGGSFA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 136 PGvIFFLALWFPAQYRTRVLA----WFTVSTPLSSLIGAPLSTWLLHLDGVLGLAGWRWMFII-EGLPACVVGFLVLKML 210
Cdd:TIGR00886 110 SC-MPWISFFFPKKIQGTALGlaagWGNMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIvPAGILLLPALLIFFVG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 211 ADRPADarwlspaerDALQGAFDREGSSsrkekhfgAALRDVRVYILALIsFGFTMGSY-GIGIWLPQMLK-AHGMTVAQ 288
Cdd:TIGR00886 189 ADTPPG---------KPATGKLSFKEAL--------KVFGNRHTWILALL-YSVTFGSFlGVSSIFAMLFKdQFGLSKVQ 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 289 TGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVGVT----LALIGTIAGRTIFYT 364
Cdd:TIGR00886 251 AGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVlfvaLFFFAGAGNGSTFAL 330
|
330 340
....*....|....*....|....*.
gi 1589895752 365 LPARFlsGQAAAGGFALINSIGALGG 390
Cdd:TIGR00886 331 VPHIF--RRATGAVSGLIGAIGNLGG 354
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
90-426 |
2.28e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.43 E-value: 2.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 90 RFGARR-WLARIMITWGLMAAATSFAVGPNS------FYVIRLLLGIGEAGFFPGVIFFLALWFP-AQYRTRVLAWFTVS 161
Cdd:COG2211 76 RWGRRRpWILIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAF 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 162 TPLSSLIGAPLSTWLLHLDGVLGLAGWRWMFIIEGLPACVVGFLVLKMLADRPAdarwlspaerdalqgafdREGSSSRK 241
Cdd:COG2211 156 AGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPV------------------PEEEKVSL 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 242 EKHFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAH-GMTVAQTGWLSA---VPYFFATIALLWWAKRVDRRGGA 317
Cdd:COG2211 218 KESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLAlyfLAALLGAPLWPRLAKRFGKKKAF 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 318 IanLAAGLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYTL------PARFLSGQAAAG-GFALINSIGALGG 390
Cdd:COG2211 298 I--IGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMladvvdYDEWKTGRRREGlYFGIFTFAIKLGQ 375
|
330 340 350
....*....|....*....|....*....|....*.
gi 1589895752 391 FAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:COG2211 376 ALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFL 411
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
247-428 |
3.16e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 3.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 247 AALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRG--GAIANLAAG 324
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGrrRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 325 LLIGGVALGVSTHFHQLgpaMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSY 404
Cdd:COG2814 85 FALGSLLCALAPSLWLL---LAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180
....*....|....*....|....
gi 1589895752 405 GTFTAGMMGLAIVLGITTLLTLSL 428
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
57-426 |
1.09e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.09 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 57 KDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFP 136
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 137 GVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWllhldgvLGLAGWRWmFIIEGLPACVVGFLVLKMLADRPAd 216
Cdd:cd17477 104 VSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLAL-------VGTAGALP-FLIAAVLLLLALVPLLLTRRAAPE- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 217 arwlspaerdalqgafdregSSSRKEKHFGAALRDVRVYILALISFGFTMGS-YGIgiwLPQMLKAHGMTVAQTGWLSAV 295
Cdd:cd17477 175 --------------------IEEAESISLRRLLRIAPLALLGAFVAGFLEGAfYSL---LPLYGLRLGLSVAQAALLLAA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 296 PYFFATIALL---WWAKRVDRRGGAIANLAAGLLIGGVALGVSTHFHQLGPAMVgVTLALIGTIagRTIFYTLPARFLSG 372
Cdd:cd17477 232 FVLGGLLLQWplgWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLF-LWGGAAGPL--YTLALALAGDRLPG 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1589895752 373 QAAAGGFALINSIGALGGFAGPYLVGYLKDSYGtfTAGMMGLAIVLGITTLLTL 426
Cdd:cd17477 309 DELVAANAALLLLYGLGSVIGPLLAGALMDAFG--PHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
164-420 |
2.97e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 42.98 E-value: 2.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 164 LSSLIGAPLSTWLLHLdgvlglAGWRWMFIieglpaCVVGFLVLKMLADRPADARWLSPAERDALQGAfdregsssRKEK 243
Cdd:cd17485 139 LGSLLGGGGLLWLYDL------IGWQSLLL------SLAALYLLLLLPVLFLRELELPQQPPASERGA--------ALKA 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 244 HFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGWLSAV--------PYFFATIALLWWAKRVDRRG 315
Cdd:cd17485 199 SLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDRGFSLSQIGLLSGVggslvsiaGSLLGGYLLKRRGRRRLLLL 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 316 GAIANLAAGLLIGGVALGVSThfhqLGPAMVGVTLALIGTIAG--RTIFYTLPARFLSGQAAAGGFALINSIGALGGFAG 393
Cdd:cd17485 279 GGLLRLLLLGLYTLLALGGSG----LNWVLLLASLALLHLVGGmiTTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLF 354
|
250 260 270
....*....|....*....|....*....|
gi 1589895752 394 PYLVGYLKDSYG---TFTAGMMGLAIVLGI 420
Cdd:cd17485 355 GSLAGFLADHLGyaaAFLLFAILSALSVLL 384
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
256-418 |
4.44e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 4.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 256 ILALISFGFTMGSYGIGIWLPQMLkahGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVS 335
Cdd:cd17330 182 VYFLIALAFAGLESVFSLFLKDRF---GFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 336 THFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLA 415
Cdd:cd17330 259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAG 338
|
...
gi 1589895752 416 IVL 418
Cdd:cd17330 339 LLL 341
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
51-220 |
4.61e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.17 E-value: 4.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 51 AALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAVGPNSFYVIRLLLGIG 130
Cdd:cd17359 23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 131 EAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTpLSSLIGAPLSTWLL---HLDGVLGLAGWRWMFIIEGLPACVVGFLVL 207
Cdd:cd17359 103 VGGASALVPMYIAEVAPAEIRGRLVSLNQLMI-VFGQLLAYIVNYLIanaGGADWLGAEGWRWMLGLEAIPAILFLLGML 181
|
170
....*....|...
gi 1589895752 208 KMladrPADARWL 220
Cdd:cd17359 182 FI----PESPRWL 190
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
33-280 |
5.71e-04 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 42.21 E-value: 5.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 33 LLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATS 112
Cdd:cd17440 3 VLGMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 113 FAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGA-------PLSTWLLHLDGVLGL 185
Cdd:cd17440 83 FVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASamawaiiPHYGWSFSMGSAYQF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 186 AGWRWMFIIEGLPaCVVGFLVLKMLADRPA--------DARWLspaerdALQGAFDRE-GSSSRKEKHFGA-ALRDVRVY 255
Cdd:cd17440 163 HSWRVFVIVCALP-CVSSVVALTFMPESPRfllevgkhDEAWM------ILKQIHDTNmRARGQPEKVFTVnRIKKDNTI 235
|
250 260
....*....|....*....|....*
gi 1589895752 256 ILALISFGFTMGSYGIGIWLPQMLK 280
Cdd:cd17440 236 KLTIVWLTLSFGYYGLSVWFPDVIK 260
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
33-280 |
6.59e-04 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 41.94 E-value: 6.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 33 LLALAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATS 112
Cdd:cd17439 3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 113 FAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGA-------PLSTWLLHLDGVLGL 185
Cdd:cd17439 83 FVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASamawaiiPHYGWSFQMGSAYQF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 186 AGWRWMFIIEGLPACvvgfLVLKMLADRPADAR-WLSPAERDALQGAFDREGSSSRKEKHFGAALRDV----RVYILALI 260
Cdd:cd17439 163 HSWRVFVLVCAFPSV----FAIGALTTMPESPRfFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVthikRRITLMMM 238
|
250 260
....*....|....*....|..
gi 1589895752 261 SFGFTM--GSYGIGIWLPQMLK 280
Cdd:cd17439 239 AVWFTMsfSYYGLTVWFPDMIK 260
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
67-202 |
8.72e-04 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 41.30 E-value: 8.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 67 GWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFA--VGPNSFYVIRLLLGIGEAGFFPGVIFFLAL 144
Cdd:cd17381 68 GWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAadLGAGYLIAVRALEGLGEGVTFPAMHAMWAS 147
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1589895752 145 WFPAQYRTRVLAWFTVSTPLSSLIGAPLS---------TWLLHLDGVLGLAGW-RWMFIIEGLPACVV 202
Cdd:cd17381 148 WAPPLERSRLLTISYAGAQLGTVVSLPLSglicyyldwTYVFYIFGAVGLLWFfLWIWLVMPLWAIVV 215
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
158-426 |
8.73e-04 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 41.41 E-value: 8.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 158 FTVSTPLSSLIGAPLSTWLLHLDGVlglaGWRWMFIIEGLPACVVGFLVLKMLADRPADArwlspaerdalqgafdregs 237
Cdd:cd17339 126 YTTSMNLGAALASGLSVPLAQALGG----GWRGALAIWALPALLALLIWLPQLRRRKRAA-------------------- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 238 SSRKEKHFGAALRDVRVYILALIsFGFT-MGSYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFF---ATIALLWWAKRVDR 313
Cdd:cd17339 182 AAAAPLTKISVWRSPLAWQVTLF-MGLQsLLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVgipASLLVPILATRLKN 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 314 RGGAIANLAAGLLIGGVALGVSTHFHQLgPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFAliNSIGALGGFAG 393
Cdd:cd17339 261 QRPIVVLLAVLFIIGVLGLLFAPTALAL-LWAVLLGLGGGAAFSLALTLISLRSSDPAEAAALSGMA--QSVGYLLAALG 337
|
250 260 270
....*....|....*....|....*....|...
gi 1589895752 394 PYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:cd17339 338 PLLFGVLHDLTGSWTAPLVLLLALTVLQLVAGL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-210 |
1.13e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.02 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 28 WRFIPLLALAYFFNYLDRTSVG-FAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGL 106
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEpFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 107 MAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWLlhldgvLGLA 186
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL------YDAF 351
|
170 180
....*....|....*....|....
gi 1589895752 187 GWRWMFIIEGLPACVVGFLVLKML 210
Cdd:cd17325 352 GFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
55-426 |
1.14e-03 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 40.82 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 55 MNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGAR-RWLARI-MITWGLMAAATSFAVGPNSFYVIRLLLGIGEA 132
Cdd:pfam06779 19 MIAEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGASRlRPALLAgLLATVLLLLAMAATSSFWAVLLIRFLAGVASA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 133 GFFpgvIFFLALWFP---AQYRTRVLAWFTVSTPLSSLIGApLSTWLLHLDGVLGLAGWrwmfiieglpacvVGFLVLKM 209
Cdd:pfam06779 99 AVM---IFGSSLILGhatAARRAFVGALLFAGVGIGIALSG-LLVPLGLQLGLGGSSLW-------------YGAGVLSA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 210 LADRPADARWLSPAERDALQGAFdregsssrkekHFGAALRDVRVYILALISFGFTMGSYGIGIWLPQMLKAHGMTVAQT 289
Cdd:pfam06779 162 VLTLAVFPLLPRRAPRHASAPAP-----------AAKPLQRSLPLWILTLAYGLAGFGYIITATFLPAMARDGFGGPAAA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 290 GWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVALGVSTHFHQLGPAMVGVtLALIGTIAGRTIFYTLPARF 369
Cdd:pfam06779 231 ALFWSLFGLAAALGVLVWLRAAKRWGTRPA-LTAALLIQALGVLLSLLSPSPAGLAVSS-LLFGGTFMAITSLVMQLARE 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1589895752 370 LSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAIVLGITTLLTL 426
Cdd:pfam06779 309 LAPPAPRRLLGLMTASFGIGQILGPLLASLLTAATGGLTPALLLAAAALVLAALIVL 365
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
257-426 |
2.10e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 257 LALISFGFTMGSYGIGIWLPQ-MLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVALGVS 335
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV-LLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 336 THFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGtFTAGMMGLA 415
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILA 158
|
170
....*....|.
gi 1589895752 416 IVLGITTLLTL 426
Cdd:pfam07690 159 ILSLLAAVLLL 169
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
257-428 |
2.38e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.10 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 257 LALISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIANLAAGLLIGGVALGVST 336
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 337 hFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAGMMGLAI 416
Cdd:cd06174 81 -APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
|
170
....*....|..
gi 1589895752 417 VLGITTLLTLSL 428
Cdd:cd06174 160 ALALLAAILLLL 171
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
36-214 |
2.76e-03 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 39.70 E-value: 2.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 36 LAYFFNYLDRTSVGFAALTMNKDLGLTATQFGWGAGIMFAGYCICEVPSNLALYRFGARRWLARIMITWGLMAAATSFAV 115
Cdd:cd17488 10 IGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 116 GPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIgAPLSTWLLHLDGvlglaGWRWMFIIE 195
Cdd:cd17488 90 SLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGAL-IPILTGFAALTY-----GWRAGMYVP 163
|
170
....*....|....*....
gi 1589895752 196 GLPACVVGFLVLKMLADRP 214
Cdd:cd17488 164 GIIAILMGIVLCWRLRDRP 182
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
257-423 |
3.50e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 39.48 E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 257 LALISFGFTMGSYGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAAGLLIGGVA---LG 333
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRL-LLLGLLLLAVStllFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 334 VSTHFHQLGPAMV--GVTLALIGTIAGRTIFYTLPARFLSGQaaaggFALINSIGALGGFAGPYLVGYLKDSYG-----T 406
Cdd:cd17325 80 FATSYWQLLLARFlqGLASAAVWPAAMALIADIAPPEERGRA-----MGIFSSAIGLGFLIGPLLGGLLADALGyrapfL 154
|
170
....*....|....*..
gi 1589895752 407 FTAGMMGLAIVLGITTL 423
Cdd:cd17325 155 VCAALALLALVLALLLL 171
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
247-431 |
5.97e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.70 E-value: 5.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 247 AALRDVRVYILALISFGFTMGS---YGIGIWLPQMLKAHGMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGGAIAnLAA 323
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYldrSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRV-LAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 324 GLLIGGVALGVSTHFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDS 403
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190
....*....|....*....|....*....|
gi 1589895752 404 YGTFTA--GMMGLAIVLGITTLLTLSLYAF 431
Cdd:COG2271 161 FGWRAAflILGLPGLLLALLRFWLLALAYF 190
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
97-428 |
7.46e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.37 E-value: 7.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 97 LARIMITWGLMAAATSFAVGPNSFYVIRLLLGIGEAGFFPGVIFFLALWFPAQYRTRVLAWFTVSTPLSSLIGAPLSTWL 176
Cdd:cd06173 72 LLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 177 LhldgvlGLAGWRWMFIIEGLPACVVGFLVLKMLADRPADARWLSPAERDALQGAFDRegsssrkekhfgaALRDVRVYI 256
Cdd:cd06173 152 V------ALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRY-------------LRRSPLLRL 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 257 LALISFGFTMGSYGIGIWLPQMLKAH-GMTVAQTGWLSAVPYFFATIALLWWAKRVDRRGgAIANLAAGLLIGGVALGVS 335
Cdd:cd06173 213 LLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR-RGRLLLIGALLLGLALLVL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1589895752 336 THFHQLGPAMVGVTLALIGTIAGRTIFYTLPARFLSGQAAAGGFALINSIGALGGFAGPYLVGYLKDSYGTFTAgMMGLA 415
Cdd:cd06173 292 GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV-FLLAG 370
|
330
....*....|...
gi 1589895752 416 IVLGITTLLTLSL 428
Cdd:cd06173 371 ALLLLAALLLLLL 383
|
|
|