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Conserved domains on  [gi|1592447822|ref|WP_132348261|]
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helix-turn-helix transcriptional regulator [Photorhabdus luminescens]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10054599)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|2644244|8831795
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 31-84 2.15e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


:

Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 39.84  E-value: 2.15e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1592447822  31 RLRQAIGdESVNSFANRCGIPESSLRNYLSGRIEPSLSKLVVFAEKSGVTVGWL 84
Cdd:cd00093     6 ELRKEKG-LTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
 
Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 31-84 2.15e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 39.84  E-value: 2.15e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1592447822  31 RLRQAIGdESVNSFANRCGIPESSLRNYLSGRIEPSLSKLVVFAEKSGVTVGWL 84
Cdd:cd00093     6 ELRKEKG-LTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
31-84 1.75e-04

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 38.05  E-value: 1.75e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1592447822  31 RLRQAIGdESVNSFANRCGIPESSLRNYLSGRIEPSLSKLVVFAEKSGVTVGWL 84
Cdd:COG1396    14 ELRKARG-LTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDEL 66
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 25-97 4.97e-04

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 38.56  E-value: 4.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592447822  25 ITEFKDRLRQAIGD-----ESVNSFANRCGIP--ESSLRNYLSGRIEPSLSKLVVFAEKSGVTVGWLAIGDTAVTEEQEN 97
Cdd:PRK13355    1 KTTFAERLKQAMKArglkqEDLVHAAEARGVKlgKSHISQYVSGKTGPRRDVLPFLAAILGVSEDWLLGGESPADQESDA 80
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
44-84 1.05e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 35.19  E-value: 1.05e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1592447822   44 FANRCGIPESSLRNYLSGRIEPSLSKLVVFAEKSGVTVGWL 84
Cdd:smart00530  16 LAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
 
Name Accession Description Interval E-value
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 31-84 2.15e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 39.84  E-value: 2.15e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1592447822  31 RLRQAIGdESVNSFANRCGIPESSLRNYLSGRIEPSLSKLVVFAEKSGVTVGWL 84
Cdd:cd00093     6 ELRKEKG-LTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
31-84 1.75e-04

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 38.05  E-value: 1.75e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1592447822  31 RLRQAIGdESVNSFANRCGIPESSLRNYLSGRIEPSLSKLVVFAEKSGVTVGWL 84
Cdd:COG1396    14 ELRKARG-LTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDEL 66
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 25-97 4.97e-04

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 38.56  E-value: 4.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1592447822  25 ITEFKDRLRQAIGD-----ESVNSFANRCGIP--ESSLRNYLSGRIEPSLSKLVVFAEKSGVTVGWLAIGDTAVTEEQEN 97
Cdd:PRK13355    1 KTTFAERLKQAMKArglkqEDLVHAAEARGVKlgKSHISQYVSGKTGPRRDVLPFLAAILGVSEDWLLGGESPADQESDA 80
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
44-84 1.05e-03

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 35.19  E-value: 1.05e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1592447822   44 FANRCGIPESSLRNYLSGRIEPSLSKLVVFAEKSGVTVGWL 84
Cdd:smart00530  16 LAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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