|
Name |
Accession |
Description |
Interval |
E-value |
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
4-372 |
1.18e-33 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 128.83 E-value: 1.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 4 ARRRLDWKVIGLVGIAHASSHFFQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGL 83
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 84 ACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFN 163
Cdd:COG2271 83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 164 WRVAAFGAGLLVAVILTMTvvgrrllaveaarrpargrrldaapagtslgallinpvVWGAFLFFMFSSVAISAVQNYTI 243
Cdd:COG2271 163 WRAAFLILGLPGLLLALLR--------------------------------------FWLLALAYFLVYFALYGFLTWLP 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 244 PILGSIYGISSVTASTALSGYMVAGACGMVLGGFLVSSGPYSERIVGMSFVAAGALLALLATGWLPVAAAVPCVALAGLC 323
Cdd:COG2271 205 TYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFG 284
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1593254606 324 AGVAGPSRDMLVRRVTPRGATGSVYGLVYSGMDTGSALAPLAFGVMLDA 372
Cdd:COG2271 285 LGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-372 |
1.03e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 104.58 E-value: 1.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 10 WKVIGLVGIAHASSHFFQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVA 89
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 90 GLLLGLASNYGWLMAAAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAF 169
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 170 GAGLLVAVILtmtvvgrrLLAVEAARRPARGRRLDAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSI 249
Cdd:COG2223 164 ILGILLLVVA--------VLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 250 YGISSVTASTALSGYMVAGACGMVLGGFLVSSGPySERIVGMSFVAAGALLALLATGWLPVAAAVPCVALAGLCAGVAGP 329
Cdd:COG2223 236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIG-GRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNG 314
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1593254606 330 SRDMLVRRVTPRGATGSVYGLVYSGMDTGSALAPLAFGVMLDA 372
Cdd:COG2223 315 AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-362 |
1.16e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 103.52 E-value: 1.16e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 4 ARRRLDWKVIGLVGIAHASSHFFQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGL 83
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 84 ACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFN 163
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 164 WRVAAFGAGLLVAVILTMTVVGRRLLAVEaarrpargrrlDAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTI 243
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPA-----------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 244 PILGSIYGISSVTASTALSGYMVAGACGMVLGGFLVSSGPYSERIVGMSFVAAGALLALLATGWLPVAAAvpCVALAGLC 323
Cdd:COG2814 232 LYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLL--ALFLLGFG 309
|
330 340 350
....*....|....*....|....*....|....*....
gi 1593254606 324 AGVAGPSRDMLVRRVTPRGATGSVYGLVYSGMDTGSALA 362
Cdd:COG2814 310 FGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
16-278 |
5.45e-20 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 90.31 E-value: 5.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 16 VGIAHASSHFFQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGL 95
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 96 ASNYGWLMAAAVVAGIGNSVFHPVDFSILNrRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFnWRVAAFGAGLLV 175
Cdd:cd17478 81 APNYWLLLLLVALAGIGSAAFHPEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALF-GGLGLLILLIIP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 176 AVILTMTVVGRRLLAVEAARRPARGRRLDAAPAGTSLGALLINpvvwgafLFFMFSSVAISAVQNYtIPILGSIYGISSV 255
Cdd:cd17478 159 GLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLL-------IIVFLRSWVLSSLTTF-LPFYLVQRGYSLV 230
|
250 260
....*....|....*....|...
gi 1593254606 256 TASTALSGYMVAGACGMVLGGFL 278
Cdd:cd17478 231 FAGLLLSLFLFAGAIGTLIGGPL 253
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
26-363 |
5.95e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 90.17 E-value: 5.95e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 26 FQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAA 105
Cdd:pfam07690 12 RSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 106 AVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFGAGLLVAVILTMTVVG 185
Cdd:pfam07690 92 RVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 186 RRllavEAARRPARGRRLDAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVqnYTIPILGSIYGISSVTASTALSGYM 265
Cdd:pfam07690 172 RP----PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLL--TYLPLYQEVLGLSALLAGLLLGLGG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 266 VAGACGMVLGGFLVSS-GPYSERIVGMSFVAAGALLALLATGWLPVAAAVPCVALAGLCAGVAGPSRDMLVRRVTPRGAT 344
Cdd:pfam07690 246 LLGAIGRLLLGRLSDRlGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER 325
|
330
....*....|....*....
gi 1593254606 345 GSVYGLVYSGMDTGSALAP 363
Cdd:pfam07690 326 GTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-380 |
1.39e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.56 E-value: 1.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 26 FQLVIPsLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAA 105
Cdd:cd17325 12 YGIIIP-ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 106 AVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFGAGLLVAVILTMtvvg 185
Cdd:cd17325 91 RFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVL---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 186 rRLLAVEAARRPARGRRLDAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSIYGISSVTASTALSGYM 265
Cdd:cd17325 167 -ALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 266 VAGACGMVLGGFLVSS-GPYSERIVGMSFVAAGALLALLATGWLPVAAAvpcVALAGLCAGVAGPSRDMLVRRVTPRGAT 344
Cdd:cd17325 246 LASALSQPPAGKLSDRiGRKPLILIGLLLSAVALLLLPLATSFWLLLLL---LALLGLGLGLVFPATLALLADIVPPEGR 322
|
330 340 350
....*....|....*....|....*....|....*.
gi 1593254606 345 GSVYGLVYSGMDTGSALAPLAFGVMLDAGLRQGPYL 380
Cdd:cd17325 323 GTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
31-372 |
4.21e-17 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 82.32 E-value: 4.21e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 31 PSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAA-AVVA 109
Cdd:cd17355 23 GVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLwGLLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 110 GIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFGAGLLVAviLTMTVVGRRLL 189
Cdd:cd17355 103 GGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLAL--LVLVPVLLLLR 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 190 AVEAARRPARGRRLDAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSIyGISSVTASTALSGYMVAGA 269
Cdd:cd17355 181 RRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GISPAAAAVALALIGLFNI 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 270 CGMVLGGFLVSSGPYSERIVGMSFVAAGALLALLATGWLPVAAAVpCVALAGLCAGVAGPSRDMLVRRVTPRGATGSVYG 349
Cdd:cd17355 260 VGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLL-FAALFGLGWGATVPLTAALAARYFGARSYGTLFG 338
|
330 340
....*....|....*....|...
gi 1593254606 350 LVYSGMDTGSALAPLAFGVMLDA 372
Cdd:cd17355 339 LVFAPHQLGSALGPWLGGLLYDR 361
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-374 |
9.04e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 81.32 E-value: 9.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 16 VGIAHASSHFFQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGL 95
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 96 ASNYGWLMAAAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFGAGLLV 175
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 176 AVILtMTVVGRRLLAVEAARRPARGRRLDAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSIYGISSV 255
Cdd:cd06174 161 LALL-AAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 256 TASTALSGYMVAGACGMVLGGFLVSSGPYSERIVGMSFVAAGALLALLATGWlPVAAAVPCVALAGLCAGVAGPSRDMLV 335
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAP-SLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350
....*....|....*....|....*....|....*....
gi 1593254606 336 RRVTPRGATGSVYGLVYSGMDTGSALAPLAFGVMLDAGL 374
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
30-372 |
2.81e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 76.84 E-value: 2.81e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 30 IPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVA 109
Cdd:COG2807 37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 110 GIGNSVFHPVDFSILNRRVSSpRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVA-AFGAGLLVAVILTMTVVGRRL 188
Cdd:COG2807 117 GAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAlAVWALLALLALLLWLPLLRRR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 189 LAVEAarrpargrrldAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSiYGISSVTASTALSGYMVAG 268
Cdd:COG2807 196 PAAAA-----------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 269 ACGMVLGGFLVSSGPYSERIVGMSFVAAGALLALLAtgWLPVAAAVPCVALAGLCAGVAGPSRDMLVRRVTPRGA-TGSV 347
Cdd:COG2807 264 IPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLL--LAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAeAAAL 341
|
330 340
....*....|....*....|....*
gi 1593254606 348 YGLVYSGMDTGSALAPLAFGVMLDA 372
Cdd:COG2807 342 SGMAQSVGYLLAALGPLLVGALHDA 366
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
29-380 |
3.95e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 73.35 E-value: 3.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 29 VIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVV 108
Cdd:COG0738 26 LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 109 AGIGNSVFHPV---DFSILNRRVSSPRLGhafSAHGITGnLGWATTPIFITTLTHL---FNWRVAAFGAGLLVAVILtmt 182
Cdd:COG0738 106 LGLGLGLLDVAanpYVAALGPETAASRLN---LLHAFFS-LGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLA--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 183 vvgrrLLAVEAARRPARGRRLDAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSIYGISSVTASTALS 262
Cdd:COG0738 179 -----LLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 263 GYMVAGACGMVLGGFLVSSGPYSERIVGMSFVAAGALLALLATGWLPVAAAvpCVALAGLCAGVAGPSRDMLVRRVTPRg 342
Cdd:COG0738 254 LFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALI--GLALVGLGLSLMFPTIFSLALDGLGK- 330
|
330 340 350
....*....|....*....|....*....|....*....
gi 1593254606 343 ATGSVYGLVYSGMDTGSALAPLAFGVMLDA-GLRQGPYL 380
Cdd:COG0738 331 RTAAAVSAVLIMGIVGGAIGPPLIGFLADAfGLRAAFLV 369
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
29-373 |
2.67e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 70.66 E-value: 2.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 29 VIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVV 108
Cdd:cd17324 17 VIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 109 AGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFGAGLLVAVILTMTVVGRRL 188
Cdd:cd17324 97 AGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 189 LAVEAARRPargrrldaaPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSIYGISSVTASTALSGYMVAG 268
Cdd:cd17324 177 LPPKKPGSL---------GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 269 ACGMVLGGFLVSSGPYSERIVGMSFVAAGALLALLATGWLPVAAAVpcVALAGLCAGVAGPSRDMLVRRVTPRgATGSVY 348
Cdd:cd17324 248 VVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVG--LVLWGLGFFAAHSALQTRVLRLAPE-ARGLAS 324
|
330 340
....*....|....*....|....*
gi 1593254606 349 GLVYSGMDTGSALAPLAFGVMLDAG 373
Cdd:cd17324 325 SLYLAAYNLGGALGAALGGLVLDHG 349
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
28-381 |
6.56e-13 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 69.56 E-value: 6.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 28 LVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAV 107
Cdd:cd17329 17 MVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 108 VAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTL-THLFNWRVAAFGAGLLVAVILTMTVVGR 186
Cdd:cd17329 97 LTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLlLYSFRLLFLAAAVLFLLAALVLLFLLPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 187 RLLAVEAArrpargrrlDAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYtIPILGS---IYGISSVTASTALSG 263
Cdd:cd17329 177 TRPKRRAA---------EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLEST-LPVYVVeilGLGESLLGLLLALNA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 264 YMVAGAcGMVLGGFLVSSGPYSERIVGMSFVAAGALLALLATGWLPVAAAVPCVALAGLcagVAGPSRDMLVRRVTPRGA 343
Cdd:cd17329 247 LLIVLL-QFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEM---LVFPAVQTLVAALAPPDK 322
|
330 340 350
....*....|....*....|....*....|....*...
gi 1593254606 344 TGSVYGLVYSGMDTGSALAPLAFGVMLDAGLRQGPYLG 381
Cdd:cd17329 323 RGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLI 360
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
18-372 |
1.02e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 68.80 E-value: 1.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 18 IAHASSHFFQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLAS 97
Cdd:cd17475 3 LAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 98 NYGWLMAAAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFGAGLLVAV 177
Cdd:cd17475 83 SYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSIL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 178 ILTMTVVGRRllaveaARRPARGRRLDAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSIYGISSVTA 257
Cdd:cd17475 163 AAVLFWLFYR------EPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 258 STALSGYMVAGACGMVLGGFLVSSGPYSERIVGMSFVAAGALLALLATGWL----PVAAAVPCVALAGLCA-GVAGPSRD 332
Cdd:cd17475 237 GALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLspgtPLWLLVLLLILLGLFAiGWNGLYLT 316
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1593254606 333 MLVRRVtPRGATGSVYGLVYSGMDTGSALAPLAFGVMLDA 372
Cdd:cd17475 317 LVAESA-GPEQAGTALGLANTINFIGIAIGPPLFGLLVDA 355
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-186 |
3.73e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.13 E-value: 3.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 2 RFARRRLDWKVIGLVGIAHASSHFFQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWF 81
Cdd:cd17325 191 GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 82 GLACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHL 161
Cdd:cd17325 271 GLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA 350
|
170 180
....*....|....*....|....*
gi 1593254606 162 FNWRVAAFGAGLLVAVILTMTVVGR 186
Cdd:cd17325 351 FGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-292 |
2.22e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 60.98 E-value: 2.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 10 WKVIGLVGIAHASSHFFQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVA 89
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 90 GLLLGLASNYGWLMAAAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAF 169
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 170 GAGLLVAVILTMTVVGRRLLAVEAARRPARGRRLDAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSI 249
Cdd:COG0477 173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1593254606 250 YGISSVTASTALSGYMVAGACGMVLGGFLVSSGPYSERIVGMS 292
Cdd:COG0477 253 LLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
10-372 |
6.70e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 60.28 E-value: 6.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 10 WKVIGLVGIAHASSHFFQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVA 89
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 90 GLLLGLASNYGWLMAAAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAF 169
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 170 GAGLLVAVILTMT-VVGRRLLAVeaarrpargrrldaapagtSLGALLINPVVWGaFLFFMFSsvaisavqnytipILGS 248
Cdd:cd17319 162 IEGLLGLLLAVLWwFYLRQVWGL-------------------ALGYFGINYALYG-LLTWLPT-------------YLKQ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 249 IYGISSVTASTALSGYMVAGACGMVLGGFLVS-SGPYSERIVGMSFVAAGALLALLATGWLPVAAAVPCVALAGLCAGVA 327
Cdd:cd17319 209 ARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAA 288
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1593254606 328 GPSRDMLVRRVTPRGATGSVYGLVYSGMDTGSALAPLAFGVMLDA 372
Cdd:cd17319 289 SPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDA 333
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
29-380 |
1.35e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 59.12 E-value: 1.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 29 VIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVV 108
Cdd:cd17474 17 IVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 109 AGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLThLFNWRVAAFGAGLLVAVILTMTVVgrrL 188
Cdd:cd17474 97 QGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILF---L 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 189 LAVEAARRPARGRRLDAAPAGTSLGALLINPVVWGAFLFFMFssvaiSAVQNYTIPILGSIYGISSVTASTALSGYMVAG 268
Cdd:cd17474 173 LPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLY-----FAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 269 ACGMVLGGFLVSSGPYSERIVGMSFVAAGALLALLAtGWLPVAAAVPCVALAGLCAGVAGPSRDMLVRRVTPRGATGSVY 348
Cdd:cd17474 248 ALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLG-FVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTAS 326
|
330 340 350
....*....|....*....|....*....|..
gi 1593254606 349 GLVYSGMDTGSALAPLAFGVMLDAGLRQGPYL 380
Cdd:cd17474 327 SLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFL 358
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
37-375 |
4.38e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.57 E-value: 4.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 37 LATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVF 116
Cdd:cd17321 22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 117 HPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFgagLLVAVILTMTVVGRRLlaveaarr 196
Cdd:cd17321 102 MPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFL---INVPIGLVALLLARTF-------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 197 pargrrldaapAGTSLGALLINPVVWGAFLFFMFssvaisavqnytipILGSIYGISSVTASTALSGYMVAGACGMVLGG 276
Cdd:cd17321 171 -----------SGAVLAAFLLGAALGGLLFLLPL--------------YLQGVLGYSPLQAGLALLPLALAMLVAAPLAG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 277 FLVSS-GPYSERIVGMSFVAAGALLALLATGWLPVAAAVPCVALAGLCAG-VAGPSRDMLVRRVtPRGATGSVYGLVYSG 354
Cdd:cd17321 226 RLADRfGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGlFATPLTNAALSSV-PKEKAGAASGILNTA 304
|
330 340
....*....|....*....|.
gi 1593254606 355 MDTGSALAPLAFGVMLDAGLR 375
Cdd:cd17321 305 RQLGGALGVALLGALLTAGLS 325
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
37-330 |
2.06e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 55.66 E-value: 2.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 37 LATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVF 116
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 117 HPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWR-------VAAFGAGLLVAVILTMTVVGRRll 189
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRaifvflaLLGLLLLLLVLLFLPETLPEEK-- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 190 aveaarrpargRRLDAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSIYGISsvtaSTALSGYMVAGA 269
Cdd:cd17320 183 -----------RKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLS----PAQFGLLFALNA 247
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1593254606 270 CGMVLGGFLVS---SGPYSERIVGM----SFVAAGALLALLATGWLPVAAAVPCVALAGLCAGVAGPS 330
Cdd:cd17320 248 IALILGSLLNGrlvRRFGPRRLLRLglllLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPN 315
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
25-380 |
5.71e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.14 E-value: 5.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 25 FFQLVIPSLfAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMA 104
Cdd:cd17489 11 SFYLLLPVL-PLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 105 AAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFN-WRVAAFGAGLLVAVILTMTV 183
Cdd:cd17489 90 LRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGfAVLFIVAAVLALLALLLVFL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 184 VGRRLLAVEAArrpargrrldaAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTipilgSIYGISSVTASTALsg 263
Cdd:cd17489 170 VKDPPPVAAEE-----------AEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFL-----PLYAAERGISNAGL-- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 264 YMVAGACGMVLGGFLVSS-----GPYSERIVGMSFVAAGALLALLATGWLPVAAAvpcVALAGLCAGVAGPSRDMLVRRV 338
Cdd:cd17489 232 FFTVYAIALLLSRPFSGKlsdrkGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLA---AVLYGLGFGLLFPALQALAVDL 308
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1593254606 339 TPRGATGSVYGLVYSGMDTGSALAPLAFGVMLDAGLRQGPYL 380
Cdd:cd17489 309 VPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFL 350
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
4-183 |
2.01e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 52.58 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 4 ARRRLDWKVIGLVGIAHASSHFFQLVIPSLFAPLATEFGLGFAEL-GVLVAVFYAISGVGQASSGFVVDRAGARPVLWFG 82
Cdd:cd17473 190 TAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALiGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 83 LACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLF 162
Cdd:cd17473 270 FALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLT 349
|
170 180
....*....|....*....|....
gi 1593254606 163 NWRVAAF---GAGLLVAVILTMTV 183
Cdd:cd17473 350 GGLSGAFlilGVLALVLAIVLLLL 373
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
26-371 |
3.33e-07 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 51.99 E-value: 3.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 26 FQLVIPSLFAplatEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGlASNYGWLMAA 105
Cdd:TIGR00881 14 FALAMPYLVE----EIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG-FSTSLWVMAA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 106 AVV-AGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWA-TTPIFITTLTHLFNWRVAAFGAGLL-VAVILTMT 182
Cdd:TIGR00881 89 LWAlNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGlLPPLVLFGIAELYSWHWVFIVPGIIaIIVSLICF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 183 VVGR------RLLAVEAARRPARGRRLDAAPAGTS-----LGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSIYG 251
Cdd:TIGR00881 169 LLLRdspqscGLPPAEEMPNEEPDGDAEKKEEELTkkqifLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 252 ISSVTASTALSGYMVAGACGMVLGGFlVSSGPYSERIVGMSFVAAGALLALLATGWLPVAAAVPCVALAGLCAG--VAGP 329
Cdd:TIGR00881 249 FSKEKASWAFTLYELGGLVGTLLAGW-LSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGflVYGP 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1593254606 330 SR--DMLVRRVTPRGATGSVYGLVYSGMDTGSALAPLAFGVMLD 371
Cdd:TIGR00881 328 QMliGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLAD 371
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
4-373 |
9.82e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 9.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 4 ARRRLDWKVIGLVGIAHASSHFFQLVIPSLFAP-LATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGAR-----P 77
Cdd:COG2211 3 AKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYfYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 78 VLWFGLACFVVAGLLL------GLASNYGWLMAAAVVAGIGNSVFHPVDFSILNRRVSSPRL-GHAFSAHGITGNLGWAT 150
Cdd:COG2211 83 WILIGAIPLALSFVLLftapdlSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEErTRLSSWRFAFAGLGGLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 151 TPIFITTLTHLF------NWRVAA--FGAGLLVAVILTMTVVGRRLLAVEaarrpargrrlDAAPAGTSLGALLINPVVW 222
Cdd:COG2211 163 ASVLPPPLVAAFggdaalGYRLTAliFAVLGLLAFLLTFFGTKERPVPEE-----------EKVSLKESLKALLKNRPFL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 223 GAFLFFMFSSVAISAVQNYTIPILGSIYGISSVTASTALSGYMVAGACGMVLGGFLVSSGPYSERIVGMSFVAAGALLAL 302
Cdd:COG2211 232 LLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1593254606 303 LATGWLPVAAAVPCVALAGLCAGVAGPSRDMLVRRVTPRG-------ATGSVYGLVYSGMDTGSALAPLAFGVMLDAG 373
Cdd:COG2211 312 FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
10-371 |
2.18e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.19 E-value: 2.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 10 WKVIGLVGIAHASSHFFQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVA 89
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 90 GLLLGLASNYgWLMAAA-VVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAA 168
Cdd:cd17312 82 NIFMGFSTSL-WFFAVLwGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 169 FGAG---LLVAVILTMTVVGRrllaveaarrpargrrldaapagtslgalliNPVVWGAFLFFMFSSVAISAVQNYTIPI 245
Cdd:cd17312 161 LVPGivgLVVAIILFFFLRDS-------------------------------PPYVWVLSLAYAFVYIVRYACLDWGPLY 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 246 LGSIYGISSVTASTALSGYMVAGACGMVLGGFLVSSGPYSERIVGMSFVAAGALLALLATGWLPVAAAVPCVALAGLCAG 325
Cdd:cd17312 210 LYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFF 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1593254606 326 VAGPsrDMLV-----RRVTPRGATGSVYGLVYSGMDTGSALAPLAFGVMLD 371
Cdd:cd17312 290 VGGP--INLIggaaaQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIID 338
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
37-187 |
2.73e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.10 E-value: 2.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 37 LATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGAR--PVLWFGLACFVVAGLLLGLASNYGWLMAAAVVAGIGNS 114
Cdd:COG2271 207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1593254606 115 VFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVA--AFGAGLLVAVILTMTVVGRR 187
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAflLLAALALLAALLALLLLRET 361
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
37-192 |
5.97e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.93 E-value: 5.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 37 LATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVF 116
Cdd:COG0738 237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1593254606 117 HPVDFSILNRRVSSPRlGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFGAGLLVAVILTMTVVGRRLLAVE 192
Cdd:COG0738 317 FPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
41-280 |
7.58e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 47.70 E-value: 7.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 41 FGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVFHPVD 120
Cdd:cd17333 26 FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 121 FSILNrRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFGAGLLVAVILTMTVVGRRLLAVEAARRPARG 200
Cdd:cd17333 106 NTFVG-ALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 201 RRLDAAPAGTSLGalliNPVVWGAFLFFMFSSVAISAVQNYTIPILGSIYGISSVTASTALSGYMVAGACGMVLGGFLVS 280
Cdd:cd17333 185 VGAFSASASRLLR----NPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR 260
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
25-178 |
1.33e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 25 FFQLVIPSLFAPLATE-FGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLM 103
Cdd:cd06173 222 LLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLL 301
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1593254606 104 AAAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFGAGLLVAVI 178
Cdd:cd06173 302 AALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLA 376
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
29-372 |
1.61e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 46.85 E-value: 1.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 29 VIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVV 108
Cdd:cd17328 17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 109 AGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLF-NWRVA---AFGAGLLVAVILTMTVV 184
Cdd:cd17328 97 VGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAfrvTGVLGVLLAILLLLFVR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 185 GRRLLAVEaarrPARGRRLDAAPAGTSLGALLINPvvwgAFLFFMFSSVAISAVQN---YTIPILG----SIYGISSVTA 257
Cdd:cd17328 177 EPPRGAAE----GGVMAKSTATSFLADLKALAKNP----SFILSTLGFTAVSFVTGalaFWAPTFFlrafGVGDLSSADV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 258 STALSGY-MVAGACGMVLGGFL----VSSGPYSERIVGM--SFVAAGALLALLATGWLPVAAAVPCVALAGLCAGVA-GP 329
Cdd:cd17328 249 GLIFGAItCIAGVLGVLLGGILadrlRRKTPRADPLVCAvgLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNwAP 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1593254606 330 SRDMLVRRVTP-RGATGSVYGLVYSGMdTGSALAPLAFGVMLDA 372
Cdd:cd17328 329 VFAILLYVVIPtRRSTASAIQILLSHL-LGDAGSPYLIGLISDL 371
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
50-179 |
1.79e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 46.42 E-value: 1.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 50 VLVAVFYAISGVGQASS-----GFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVFHPVDFSIL 124
Cdd:cd17330 210 SQIGLLLALVGIAGILAqllliPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALL 289
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1593254606 125 NRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFGAGLLVAVIL 179
Cdd:cd17330 290 SKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIAL 344
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
37-182 |
1.54e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 43.72 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 37 LATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVF 116
Cdd:cd17503 22 IMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVL 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1593254606 117 HPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFGAGLLVAVILTMT 182
Cdd:cd17503 102 IPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA 167
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
32-179 |
1.58e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.30 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 32 SLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVAGI 111
Cdd:cd17370 220 AFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGL 299
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1593254606 112 GNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVA-AFGAGLLVAVIL 179
Cdd:cd17370 300 YMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAfLFSAVLALIALL 368
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
25-374 |
1.58e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.36 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 25 FFQLVIPSLFAPLATE---FGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGW 101
Cdd:cd17316 12 AYDFFLIGFVAPVLAAefsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPIL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 102 LMAAAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGW----ATTPIFITTLTHLFNWRVAAFGAGLLVav 177
Cdd:cd17316 92 LLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGAllaaLVASLLIPLLSGDWGWRILFLIGALPA-- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 178 iltmtvvgrrllaveaarrpargrrldaapagtsLGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSIYGISSVTA 257
Cdd:cd17316 170 ----------------------------------LLALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 258 STALSGYMVAGACGMVLGGFLVSSGPYSERIVGMSFVAAGALLALLATGWLPVAAAVPCVALAGLCAGVAGPSRDMLVRR 337
Cdd:cd17316 216 SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAE 295
|
330 340 350
....*....|....*....|....*....|....*..
gi 1593254606 338 VTPRGATGSVYGLVYSGMDTGSALAPLAFGVMLDAGL 374
Cdd:cd17316 296 LFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG 332
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
29-322 |
1.66e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.32 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 29 VIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVV 108
Cdd:cd17477 14 LLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 109 AGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHlFNWRVAAFGAGLLVAVILTMTVVGRRL 188
Cdd:cd17477 94 MGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGT-AGALPFLIAAVLLLLALVPLLLTRRAA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 189 LAVEAARRPARGRRLDAAPAGtslgallinpvVWGAFLFFMFSSVAISAvqnytIPILGSIYGISSVTASTALSGYMVAG 268
Cdd:cd17477 173 PEIEEAESISLRRLLRIAPLA-----------LLGAFVAGFLEGAFYSL-----LPLYGLRLGLSVAQAALLLAAFVLGG 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1593254606 269 ACGMVLGGFLVSSGPYSERIVGMSFVAAGALLALLATGWLPVAAAVPCVALAGL 322
Cdd:cd17477 237 LLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGA 290
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
4-119 |
1.74e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.31 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 4 ARRRLDWKVIGLVGIAHASSHFFQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGL 83
Cdd:cd17478 188 STLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASL 267
|
90 100 110
....*....|....*....|....*....|....*.
gi 1593254606 84 ACFVVAGLLLgLASNYGWLMAAAVVAGIGNSVFHPV 119
Cdd:cd17478 268 LLAAPFLLLF-LLTPGIWSYILLVLAGFLLFASFPV 302
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
28-112 |
1.86e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 43.44 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 28 LVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAV 107
Cdd:cd17371 16 LLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95
|
....*
gi 1593254606 108 VAGIG 112
Cdd:cd17371 96 LAGLG 100
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
37-280 |
2.00e-04 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 43.02 E-value: 2.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 37 LATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVF 116
Cdd:cd17393 25 IKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGAL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 117 ------HPVDFSILNRRVSSPRLGHAFSAHGITGNL-GWATTPIFITTLTHLfnwrvaafgaGLLVAVILTMTVVGRRLL 189
Cdd:cd17393 105 dvamnaQGVAVERAYGRPIMSSLHAMWSLGGLAGALlGAAAIGAGVSPGVHL----------LAAAVLLLLAALVAIRAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 190 AVEAARRPArgrrlDAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSIYGISSVTASTALSGYMVAGA 269
Cdd:cd17393 175 LPGTGEAAE-----DRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMT 249
|
250
....*....|.
gi 1593254606 270 CGMVLGGFLVS 280
Cdd:cd17393 250 VGRLFGDRLVD 260
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
30-181 |
2.33e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 42.97 E-value: 2.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 30 IPSLFApLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVA 109
Cdd:PRK11652 28 VPAIAD-MARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQ 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1593254606 110 GIGNSVFHPVDFSILNRRVSSPRLGHAFSAHgitgNLGWATTPI---FI-TTLTHLFNWR-VAAFGAGLLVAVILTM 181
Cdd:PRK11652 107 GLGTGVGGVMARTLPRDLYEGTQLRHANSLL----NMGILVSPLlapLIgGLLTTLFGWRaCYLFLLLLGAGVTFSM 179
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
48-381 |
2.59e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.99 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 48 LGVLVAVFYAISGVGQASSGFVVDRAGARPVLWF-----GLACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVFHPVDFS 122
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 123 ILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAfgagLLVAVILTMTVVGRRLLAVEAARRPARGRR 202
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF----AINALSFLLSALLLLFIRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 203 LDAAPAGTSLGALLINPVVWGAFLFFMFSSVAISAVQNYTIPILGSIYGISSVTASTALSGYMVAGACGMVLGGFLVSSG 282
Cdd:cd06173 192 LLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 283 PYSERIVGMSFVAAGALLALLATGWLPVAAAvpCVALAGLCAGVAGPSRDMLVRRVTPRGATGSVYGLVYSGMDTGSALA 362
Cdd:cd06173 272 RRGRLLLIGALLLGLALLVLGLSPSLWLLLA--ALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG 349
|
330
....*....|....*....
gi 1593254606 363 PLAFGVMLDAGLRQGPYLG 381
Cdd:cd06173 350 ALLAGLLADALGLSAVFLL 368
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
26-278 |
3.35e-04 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 42.39 E-value: 3.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 26 FQLVIPSLFaplaTEFGLGFAELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAA 105
Cdd:cd17488 22 FNAAMPAML----ADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAVL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 106 AVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFGAG---LLVAVILTMT 182
Cdd:cd17488 98 WTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGiiaILMGIVLCWR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 183 VVGRrllaveaarrpargrrldaapagtslgalliNPVVWGAFLFFMFSSVAISAVQNYTIPILGSIYGISSVTASTALS 262
Cdd:cd17488 178 LRDR-------------------------------PPYIWLLAFCYVLVYVVRTAINDWGNLYLSETHGYSLVKANSAVS 226
|
250
....*....|....*.
gi 1593254606 263 GYMVAGACGMVLGGFL 278
Cdd:cd17488 227 LFEVGGLIGALVAGWG 242
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
26-380 |
5.41e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.79 E-value: 5.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 26 FQLVIPSL--FAPLATEFGLGFAELGVLVAVFyaisGVGQASSGFVV----DRAGARPVLWFGLACFVVAGLLLGLASNY 99
Cdd:cd17330 12 FGIVFPVLpfYVREFNKLGASGYYVGLLQSSY----SLGQFLASPLWgrlsDRYGRKPVLLLSLAGSAVSYVLLGLSRNL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 100 GWLMAAAVVAGIGNSVFhPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLF-----NWRVAAFGAGLL 174
Cdd:cd17330 88 WLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYgyalpFLVAAALALLNL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 175 VAVILTMTVVGRRLLaveaarrpargrrldaapagTSLGALLINPVVWGAFLFFMFSSVAISAVQnytIPILGSIYGISS 254
Cdd:cd17330 167 VLVLFFLPPLRRLLL--------------------VYFLIALAFAGLESVFSLFLKDRFGFSPSQ---IGLLLALVGIAG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 255 VTASTALSGYMV--AGACGMVLGGFLVSsgpyserIVGMSFVAAGALlallatgwlpVAAAVPCVALAGLCAGVAGPSRD 332
Cdd:cd17330 224 ILAQLLLIPRLAkrLGERKLLRLGLLLA-------IIGLLLLPFASS----------VPLLVLAAAILAFGTGIVFPALS 286
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1593254606 333 MLVRRVTPRGATGSVYGLVYSGMDTGSALAPLAFGVMLDAGLRQGPYL 380
Cdd:cd17330 287 ALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFL 334
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
37-191 |
1.25e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.64 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 37 LATEFGL--GFAELGVLVAVFYAISG-VGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVAGIGN 113
Cdd:cd17317 13 IVTEWDLvcDRDWLVALVQTIFFLGVlIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 114 SVFHPVDFSILNRRVSsprlGHAFSAHGITGNLGWATTPIFITTLTHLF-NWRVAAFGAGLL-VAVILTMTVVGRRLLAV 191
Cdd:cd17317 93 AGIFTVGFVLGMEIVG----PKYRSFVGILFGLFWALGYMLLALLAYLIrDWRWLQLAISLPgLLFLLLLWWLPRRTIIV 168
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
37-183 |
1.46e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 40.25 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 37 LATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDR---AGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVAGIGN 113
Cdd:cd17319 206 LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGI 285
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1593254606 114 SVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPI---FITTLTHLFNWRVAAFGAGLLVAVILTMTV 183
Cdd:cd17319 286 GAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLligYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
25-179 |
1.81e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 25 FFQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGvgqassGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMA 104
Cdd:cd17474 220 YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVG------RLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLI 293
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1593254606 105 AAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHLFNWRVAAFGAGLLVAVIL 179
Cdd:cd17474 294 AIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAA 368
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
3-178 |
2.25e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.72 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 3 FARRRLDWKVIGLVGIAHASSHFFQLVIPSLFAPLATEFGLGFAELGVLVAVFYAISGVGQASSGFVVDR-AGARPVLWF 81
Cdd:cd06174 196 LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLI 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 82 GLACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGNLGWATTPIFITTLTHL 161
Cdd:cd06174 276 GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
|
170
....*....|....*..
gi 1593254606 162 FNWRVAAFGAGLLVAVI 178
Cdd:cd06174 356 TFGLTGAFLVLAVLLLL 372
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
66-373 |
4.83e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 38.71 E-value: 4.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 66 SGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVAGIGNSVFHPVDFSILNRRVSSPRLGHAFSAHGITGN 145
Cdd:cd17473 55 AGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMS 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 146 LGWATTPIFITTLThLFNWRV--AAFGAGLLVAVILTMTVVGRRLLAVEaarrpargrrldAAPAGTSLGALLINPVVWG 223
Cdd:cd17473 135 LGGVVFLLLGGALA-EIGWRApfLVYLLALPVLILVLLFLPEPARKSKS------------AASPGAATAAALPWKRVLP 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 224 AFLFFMFSSVAISAVQNYTIPILGSIYGISSVTASTALSGYMVAGACGMVLGGFLVSSGPYsERIVGMSFVAAGALLALL 303
Cdd:cd17473 202 IYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK-RRLLAIGFALMALGFLLL 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1593254606 304 ATgWLPVAAAVPCVALAGLCAGVAGPSRDMLVRRVTPRGATGSVYGLVYSGMDTGSALAPLAFGVMLDAG 373
Cdd:cd17473 281 AL-ASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLT 349
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
47-112 |
7.85e-03 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 38.15 E-value: 7.85e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1593254606 47 ELGVLVAVFYAISGVGQASSGFVVDRAGARPVLWFGLACFVVAGLLLGLASNYGWLMAAAVVAGIG 112
Cdd:cd17437 33 QEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIG 98
|
|
| |
