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Conserved domains on  [gi|1601809810|ref|WP_134198272|]
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MULTISPECIES: pyruvate kinase [Flavobacteriaceae]

Protein Classification

pyruvate kinase( domain architecture ID 11422070)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
5-475 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 713.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMK-GE 83
Cdd:COG0469     3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKeGP 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  84 VIVNEGDEIIFATGKrFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKsEVKARVIQGGPLKSKKGVNLP 163
Cdd:COG0469    83 VELKKGDTFTLTTDD-VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGD-EVVCEVVNGGVLSSRKGVNLP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 164 NTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHkIPIIAKIEKPEAVENIDKIVAYCDGLM 243
Cdd:COG0469   161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGR-APIIAKIEKPEAVENLDEIIEASDGIM 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 244 VARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGSYP 323
Cdd:COG0469   240 VARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYP 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 324 VQVIRQMANIIRSVEDSPLIQVPQSPPHIRTKRYITKSICYHAAHMANEIDAKAISTLTNSGYTAFQISAWRPSSHILVF 403
Cdd:COG0469   320 VEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILAL 399
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1601809810 404 TSNKRILTQLSLLWGVKAFYYDKFVSTDETIEDVNAIACKKGYLETGDMLVSLAAMPIQEKGMVNTLRVTEI 475
Cdd:COG0469   400 TPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
 
Name Accession Description Interval E-value
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
5-475 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 713.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMK-GE 83
Cdd:COG0469     3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKeGP 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  84 VIVNEGDEIIFATGKrFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKsEVKARVIQGGPLKSKKGVNLP 163
Cdd:COG0469    83 VELKKGDTFTLTTDD-VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGD-EVVCEVVNGGVLSSRKGVNLP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 164 NTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHkIPIIAKIEKPEAVENIDKIVAYCDGLM 243
Cdd:COG0469   161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGR-APIIAKIEKPEAVENLDEIIEASDGIM 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 244 VARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGSYP 323
Cdd:COG0469   240 VARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYP 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 324 VQVIRQMANIIRSVEDSPLIQVPQSPPHIRTKRYITKSICYHAAHMANEIDAKAISTLTNSGYTAFQISAWRPSSHILVF 403
Cdd:COG0469   320 VEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILAL 399
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1601809810 404 TSNKRILTQLSLLWGVKAFYYDKFVSTDETIEDVNAIACKKGYLETGDMLVSLAAMPIQEKGMVNTLRVTEI 475
Cdd:COG0469   400 TPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
5-472 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 524.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMK-GE 83
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKgGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  84 VIVNEGDEIIFATG-KRFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKsEVKARVIQGGPLKSKKGVNL 162
Cdd:TIGR01064  81 VKLKKGDKVIITTDdIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGD-KVICEVLNGGTLKSKKGVNL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 163 PNTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHKIPIIAKIEKPEAVENIDKIVAYCDGL 242
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 243 MVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGSY 322
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 323 PVQVIRQMANIIRSVEDSPLIQVpqSPPHIRT----KRYITKSICYHAAHMANEIDAKAISTLTNSGYTAFQISAWRPSS 398
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKALAYLT--NFNDRKNsdpkPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNA 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1601809810 399 HILVFTSNKRILTQLSLLWGVKAFYYDKFVS-TDETIEDVNAIACKKGYLETGDMLVSLAAMPIQEKGMVNTLRV 472
Cdd:TIGR01064 398 PIIAVTPNERVARQLALYWGVFPFLVDEEPSdTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
PRK05826 PRK05826
pyruvate kinase; Provisional
5-454 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 522.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMK-GE 83
Cdd:PRK05826    4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKeGK 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  84 VIVNEGDEIIFATGKRFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKsEVKARVIQGGPLKSKKGVNLP 163
Cdd:PRK05826   84 ITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGD-EVETEVKNGGPLSNNKGINIP 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 164 NTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHKIPIIAKIEKPEAVENIDKIVAYCDGLM 243
Cdd:PRK05826  163 GGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDGIM 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 244 VARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGSYP 323
Cdd:PRK05826  243 VARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYP 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 324 VQVIRQMANIIRSVEDSPLIQVPQSPPHI---RTKRYITKSICYHAAHMAneiDAKAISTLTNSGYTAFQISAWRPSSHI 400
Cdd:PRK05826  323 VEAVEAMARICKGAEKEFSINLSKHRLDRqfdRIDEAIAMSAMYAANHLK---GVKAIVALTESGRTARLISRFRPGAPI 399
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1601809810 401 LVFTSNKRILTQLSLLWGVKAFYYDKFVSTDETIEDVNAIACKKGYLETGDMLV 454
Cdd:PRK05826  400 FAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVV 453
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
5-472 2.09e-168

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 483.35  E-value: 2.09e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMKG-- 82
Cdd:cd00288     2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGgk 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  83 EVIVNEGDEIIFATG-KRFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKSEVKARVIQGGPLKSKKGVN 161
Cdd:cd00288    82 DISLKAGDKFLVTTDpAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKTLVCEVLNGGVLGSRKGVN 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 162 LPNTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHkIPIIAKIEKPEAVENIDKIVAYCDG 241
Cdd:cd00288   162 LPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKD-IKIIAKIENQEGVNNFDEILEASDG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 242 LMVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGS 321
Cdd:cd00288   241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 322 YPVQVIRQMANIIRSVEDSPLIQVPQSPPHIRTKRY--ITKSICYHAAHMANEIDAKAISTLTNSGYTAFQISAWRPSSH 399
Cdd:cd00288   321 YPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPtsTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1601809810 400 ILVFTSNKRILTQLSLLWGVKAFYYDKFV-----STDETIEDVNAIACKKGYLETGDMLVSLAAMPIQeKGMVNTLRV 472
Cdd:cd00288   401 IIAVTRNEQTARQLHLYRGVYPVLFEEPKpgwqeDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRI 477
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
5-338 6.71e-132

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 385.18  E-value: 6.71e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMKG-- 82
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDgk 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  83 -EVIVNEGDEIIFAT--GKRFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKSEVKARVIQGGPLKSKKG 159
Cdd:pfam00224  82 kDIELKAGDEMIVSTdaKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKTLVVEVLNGGVIGSRKG 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 160 VNLPNTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHkIPIIAKIEKPEAVENIDKIVAYC 239
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKN-IQIIAKIENQEGVNNFDEILEAT 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 240 DGLMVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSV 319
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
                         330
                  ....*....|....*....
gi 1601809810 320 GSYPVQVIRQMANIIRSVE 338
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAE 339
 
Name Accession Description Interval E-value
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
5-475 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 713.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMK-GE 83
Cdd:COG0469     3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKeGP 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  84 VIVNEGDEIIFATGKrFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKsEVKARVIQGGPLKSKKGVNLP 163
Cdd:COG0469    83 VELKKGDTFTLTTDD-VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGD-EVVCEVVNGGVLSSRKGVNLP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 164 NTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHkIPIIAKIEKPEAVENIDKIVAYCDGLM 243
Cdd:COG0469   161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGR-APIIAKIEKPEAVENLDEIIEASDGIM 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 244 VARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGSYP 323
Cdd:COG0469   240 VARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYP 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 324 VQVIRQMANIIRSVEDSPLIQVPQSPPHIRTKRYITKSICYHAAHMANEIDAKAISTLTNSGYTAFQISAWRPSSHILVF 403
Cdd:COG0469   320 VEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILAL 399
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1601809810 404 TSNKRILTQLSLLWGVKAFYYDKFVSTDETIEDVNAIACKKGYLETGDMLVSLAAMPIQEKGMVNTLRVTEI 475
Cdd:COG0469   400 TPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
5-472 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 524.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMK-GE 83
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKgGE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  84 VIVNEGDEIIFATG-KRFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKsEVKARVIQGGPLKSKKGVNL 162
Cdd:TIGR01064  81 VKLKKGDKVIITTDdIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGD-KVICEVLNGGTLKSKKGVNL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 163 PNTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHKIPIIAKIEKPEAVENIDKIVAYCDGL 242
Cdd:TIGR01064 160 PGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGAKDVKIIAKIENQEGVDNIDEIAEASDGI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 243 MVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGSY 322
Cdd:TIGR01064 240 MVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKY 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 323 PVQVIRQMANIIRSVEDSPLIQVpqSPPHIRT----KRYITKSICYHAAHMANEIDAKAISTLTNSGYTAFQISAWRPSS 398
Cdd:TIGR01064 320 PVEAVQMMAKIAKEAEKALAYLT--NFNDRKNsdpkPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNA 397
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1601809810 399 HILVFTSNKRILTQLSLLWGVKAFYYDKFVS-TDETIEDVNAIACKKGYLETGDMLVSLAAMPIQEKGMVNTLRV 472
Cdd:TIGR01064 398 PIIAVTPNERVARQLALYWGVFPFLVDEEPSdTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
PRK05826 PRK05826
pyruvate kinase; Provisional
5-454 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 522.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMK-GE 83
Cdd:PRK05826    4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKeGK 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  84 VIVNEGDEIIFATGKRFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKsEVKARVIQGGPLKSKKGVNLP 163
Cdd:PRK05826   84 ITLKTGDKFTLDTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGD-EVETEVKNGGPLSNNKGINIP 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 164 NTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHKIPIIAKIEKPEAVENIDKIVAYCDGLM 243
Cdd:PRK05826  163 GGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDNIDEIIEASDGIM 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 244 VARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGSYP 323
Cdd:PRK05826  243 VARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKYP 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 324 VQVIRQMANIIRSVEDSPLIQVPQSPPHI---RTKRYITKSICYHAAHMAneiDAKAISTLTNSGYTAFQISAWRPSSHI 400
Cdd:PRK05826  323 VEAVEAMARICKGAEKEFSINLSKHRLDRqfdRIDEAIAMSAMYAANHLK---GVKAIVALTESGRTARLISRFRPGAPI 399
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1601809810 401 LVFTSNKRILTQLSLLWGVKAFYYDKFVSTDETIEDVNAIACKKGYLETGDMLV 454
Cdd:PRK05826  400 FAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVV 453
PRK06247 PRK06247
pyruvate kinase; Provisional
1-475 6.32e-180

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 512.55  E-value: 6.32e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   1 MPKRKKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVM 80
Cdd:PRK06247    1 MKRNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  81 K-GEVIVNEGDEIIFATGKRfEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKSeVKARVIQGGPLKSKKG 159
Cdd:PRK06247   81 AdGKVQLANGQTFRLDVDDA-PGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDD-VVCRVVEGGPVSDRKG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 160 VNLPNTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEhsehKIPIIAKIEKPEAVENIDKIVAYC 239
Cdd:PRK06247  159 VSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGG----RVPVMAKIEKPQAIDRLEAIVEAS 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 240 DGLMVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSV 319
Cdd:PRK06247  235 DAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETAS 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 320 GSYPVQVIRQMANIIRSVED----SPLIQVPQSPPHiRTKRyitKSICYHAAHMANEIDAKAISTLTNSGYTAFQISAWR 395
Cdd:PRK06247  315 GKYPVEAVRTMARIIRQVERdptyPPLIHAQRPQPE-ATKR---DAISYAARDIAERLDLAALVAYTSSGDTALRAARER 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 396 PSSHILVFTSNKRILTQLSLLWGVKAFYYDKFVSTDETIEDVNAIACKKGYLETGDMLVSLAAMPIQEKGMVNTLRVTEI 475
Cdd:PRK06247  391 PPLPILALTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYI 470
PRK06354 PRK06354
pyruvate kinase; Provisional
5-477 2.20e-179

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 515.25  E-value: 2.20e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMK-GE 83
Cdd:PRK06354    8 RRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEdGP 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  84 VIVNEGDEIIFaTGKRFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKS-EVKARVIQGGPLKSKKGVNL 162
Cdd:PRK06354   88 IELKTGDEFIL-TSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgELHCKVLVGGVLSNKKGVNF 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 163 PNTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHKIPIIAKIEKPEAVENIDKIVAYCDGL 242
Cdd:PRK06354  167 PGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAIDNIDAILELCDGL 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 243 MVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGSY 322
Cdd:PRK06354  247 MVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDY 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 323 PVQVIRQMANIIRSVE-DSPLIQVPQSPPHIRTKryITKSICYHAAHMANEIDAKAISTLTNSGYTAFQISAWRPSSHIL 401
Cdd:PRK06354  327 PVEAVQTMATIAVRIEkDLPYRDILSKRPEFTTT--ITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPIL 404
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1601809810 402 VFTSNKRILTQLSLLWGVKAFYYDKFVSTDETIEDVNAIACKKGYLETGDMLVSLAAMPIQEKGMVNTLRVTEITS 477
Cdd:PRK06354  405 AVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGA 480
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
5-472 2.09e-168

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 483.35  E-value: 2.09e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMKG-- 82
Cdd:cd00288     2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGgk 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  83 EVIVNEGDEIIFATG-KRFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKSEVKARVIQGGPLKSKKGVN 161
Cdd:cd00288    82 DISLKAGDKFLVTTDpAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKTLVCEVLNGGVLGSRKGVN 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 162 LPNTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHkIPIIAKIEKPEAVENIDKIVAYCDG 241
Cdd:cd00288   162 LPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKD-IKIIAKIENQEGVNNFDEILEASDG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 242 LMVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGS 321
Cdd:cd00288   241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 322 YPVQVIRQMANIIRSVEDSPLIQVPQSPPHIRTKRY--ITKSICYHAAHMANEIDAKAISTLTNSGYTAFQISAWRPSSH 399
Cdd:cd00288   321 YPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPtsTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1601809810 400 ILVFTSNKRILTQLSLLWGVKAFYYDKFV-----STDETIEDVNAIACKKGYLETGDMLVSLAAMPIQeKGMVNTLRV 472
Cdd:cd00288   401 IIAVTRNEQTARQLHLYRGVYPVLFEEPKpgwqeDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVG-SGSTNTMRI 477
PRK09206 PRK09206
pyruvate kinase PykF;
5-472 2.41e-141

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 414.07  E-value: 2.41e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMKG-- 82
Cdd:PRK09206    2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGgn 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  83 EVIVNEGDEIIFATGKRFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTdKKSEVKARVIQGGPLKSKKGVNL 162
Cdd:PRK09206   82 DVSLKAGQTFTFTTDKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAI-TGNEVICKVLNNGDLGENKGVNL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 163 PNTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHKIPIIAKIEKPEAVENIDKIVAYCDGL 242
Cdd:PRK09206  161 PGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQEGLNNFDEILEASDGI 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 243 MVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGSY 322
Cdd:PRK09206  241 MVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKY 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 323 PVQVIRQMANIIRSVEdsPLIQVPQSPPHIRTKRYITKSICYHAAHMANEIDAKAISTLTNSGYTAFQISAWRPSSHILV 402
Cdd:PRK09206  321 PLEAVSIMATICERTD--RVMNSRLESNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILA 398
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 403 FTSNKRILTQLSLLWGVKAFYYDKFVSTDETIEDVNAIACKKGYLETGDMLVsLAAMPIQEKGMVNTLRV 472
Cdd:PRK09206  399 LTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVV-MVSGALVPSGTTNTASV 467
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
5-338 6.71e-132

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 385.18  E-value: 6.71e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMKG-- 82
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDgk 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  83 -EVIVNEGDEIIFAT--GKRFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKSEVKARVIQGGPLKSKKG 159
Cdd:pfam00224  82 kDIELKAGDEMIVSTdaKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKTLVVEVLNGGVIGSRKG 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 160 VNLPNTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHkIPIIAKIEKPEAVENIDKIVAYC 239
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKN-IQIIAKIENQEGVNNFDEILEAT 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 240 DGLMVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSV 319
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
                         330
                  ....*....|....*....
gi 1601809810 320 GSYPVQVIRQMANIIRSVE 338
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAE 339
PLN02623 PLN02623
pyruvate kinase
4-461 1.43e-108

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 333.82  E-value: 1.43e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   4 RKKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNA-AILGDLQGPKLRVGVMKG 82
Cdd:PLN02623  109 RRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNViAIMLDTKGPEVRSGDLPQ 188
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  83 EVIVNEGDEIIFaTGKRFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKSeVKARVIQGGPLKSKKGVNL 162
Cdd:PLN02623  189 PIMLEEGQEFTF-TIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDS-VKCEVVDGGELKSRRHLNV 266
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 163 PNTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEhKIPIIAKIEKPEAVENIDKIVAYCDGL 242
Cdd:PLN02623  267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNA-DIHVIVKIESADSIPNLHSIITASDGA 345
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 243 MVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGSY 322
Cdd:PLN02623  346 MVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKF 425
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 323 PVQVIRQMANIIRSVEDSplIQVPQSPPHIRT--KRYITKSICYHAAHMANEIDAkAISTLTNSGYTAFQISAWRPSSHI 400
Cdd:PLN02623  426 PLKAVKVMHTVALRTEAT--LPEGTTPPNLGQafKNHMSEMFAFHATMMANTLGT-SIIVFTRTGFMAILLSHYRPSGTI 502
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1601809810 401 LVFTSNKRILTQLSLLWGVKAFYYDKFVSTDETIEDVNAIACKKGYLETGD--MLVSLAAMPI 461
Cdd:PLN02623  503 FAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEevALVQSGRQPI 565
PLN02461 PLN02461
Probable pyruvate kinase
3-456 2.38e-106

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 325.78  E-value: 2.38e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   3 KRKKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMK- 81
Cdd:PLN02461   19 RRPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKd 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  82 GEVI-VNEGDEIIFATGKRFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDK-KSEVKARVIQGGPLKSKKG 159
Cdd:PLN02461   99 GKPVqLKQGQEITITTDYSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVeAGTVRCRCENSAMLGERKN 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 160 VNLPNTNISQPALTEKDIEDAI-FAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHkIPIIAKIEKPEAVENIDKIVAY 238
Cdd:PLN02461  179 VNLPGVVVDLPTLTEKDKEDILqWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKS-ILLISKVENQEGLDNFDDILAE 257
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 239 CDGLMVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETS 318
Cdd:PLN02461  258 SDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETA 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 319 VGSYPVQVIRQMANIIRSVEDS-----------PLIQVPQSPphirtkryiTKSICYHAAHMANEIDAKAISTLTNSGYT 387
Cdd:PLN02461  338 AGAYPELAVKTMARICREAEASldygalfkeimRSAPLPMSP---------LESLASSAVRTANKVKASLIVVLTRGGTT 408
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 388 AFQISAWRPSSHILV------------FTSNKRILTQLSLLW-GV---------KAFYYDkfvSTDETIEDVNAIACKKG 445
Cdd:PLN02461  409 ARLVAKYRPAVPILSvvvpeittdsfdWSCSDEAPARHSLIYrGLipvlaegsaKATDSE---STEEILEAAIEHAKKKG 485
                         490
                  ....*....|.
gi 1601809810 446 YLETGDMLVSL 456
Cdd:PLN02461  486 LCKPGDSVVAL 496
PTZ00066 PTZ00066
pyruvate kinase; Provisional
5-475 1.46e-103

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 318.63  E-value: 1.46e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRE-LNDEFGYNAAILGDLQGPKLRVGVMKG- 82
Cdd:PTZ00066   38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREaAKARPNANLGILLDTKGPEIRTGFLKNh 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  83 -EVIVNEGDEIIFATGKRFEGTKERVYMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKsEVKARVIQGGPLKSKKGVN 161
Cdd:PTZ00066  118 kPITLKEGQTLKITTDYTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDD-YIITKVLNNATIGERKNMN 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 162 LPNTNISQPALTEKDIEDAI-FAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHkIPIIAKIEKPEAVENIDKIVAYCD 240
Cdd:PTZ00066  197 LPGVKVELPVIGEKDKNDILnFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRH-IKIIPKIENIEGLINFDEILAESD 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 241 GLMVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVG 320
Cdd:PTZ00066  276 GIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANG 355
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 321 SYPVQVIRQMANIIRSVE---DSPLI---QVPQSPPHIRTKRYITKSicyhAAHMANEIDAKAISTLTNSGYTAFQISAW 394
Cdd:PTZ00066  356 KFPVEAVNIMAKICFEAEtciDYRVLyhaIHLAVPTPVSVQEAVARS----AVETAEDINAKLIIALTETGNTARLISKY 431
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 395 RPSSHILVFTSNKRILTQLSLLWGVKAFYYDKFVSTDETIEDVNAIACKKGYLETGDMLVSLAAMPIQEKGMVNTLRVTE 474
Cdd:PTZ00066  432 RPSCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKVVK 511

                  .
gi 1601809810 475 I 475
Cdd:PTZ00066  512 I 512
PTZ00300 PTZ00300
pyruvate kinase; Provisional
31-472 1.50e-100

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 308.90  E-value: 1.50e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  31 VDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMKGEVIVNE-GDEIIFATGKRFE--GTKERV 107
Cdd:PTZ00300    1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMErGATCYVTTDPAFAdkGTKDKF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 108 YMTYDSFPQDAKPGERILLDDGKLIFEVVSTDKKSEVKARVIQGGPLKSKKGVNLPNTNISQPALTEKDIEDAIFAIKMQ 187
Cdd:PTZ00300   81 YIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 188 VDWIALSFVRHAEDLIQLEELIKEHSeHKIPIIAKIEKPEAVENIDKIVAYCDGLMVARGDLGVEIPAEEVPLIQKQLVL 267
Cdd:PTZ00300  161 VDMIFASFIRSAEQVGEVRKALGAKG-GDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILIS 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 268 RAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGSYPVQVIRQMANIIRSVEDS------- 340
Cdd:PTZ00300  240 KCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAvneyvff 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 341 ----PLIQVPQSPphirtkryiTKSICYHAAHMANEIDAKAISTLTNSGYTAFQISAWRPSSHILVFTSNKRILTQLSLL 416
Cdd:PTZ00300  320 nsikKLQPIPMSA---------EEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNIT 390
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1601809810 417 WGVKAFYYD-KFVSTDETIEDVNAI----ACKKGYLETGDMLVSLAAMPiQEKGMVNTLRV 472
Cdd:PTZ00300  391 QGVESVFFDaERLGHDEGKEQRVAMgvgfAKSKGYVQSGDLMVVVHADH-KVKGYANQTRI 450
PRK06739 PRK06739
pyruvate kinase; Validated
10-330 3.78e-91

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 281.45  E-value: 3.78e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  10 VATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDefgyNAAILGDLQGPKLRVGVMKGE-VIVNE 88
Cdd:PRK06739    6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDD----SIKILGDVQGPKIRLGEIKGEqITLQA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  89 GDEIIFATgKRFEGTKERVYMTYDSFPQDAKPGERILLDDGK--LIFEVVSTDKkseVKARVIQGGPLKSKKGVNLPNTN 166
Cdd:PRK06739   82 GDSFILHT-QPVTGSSTEASVDYEGIANDVKVGSRILMNDGEveLIVEKVSTDK---IETKVKTGGNISSHKGVNLPGAI 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 167 ISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHKIPIIAKIEKPEAVENIDKIVAYCDGLMVAR 246
Cdd:PRK06739  158 VRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPNLIAKIETMEAIENFQDICKEADGIMIAR 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 247 GDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGSYPVQV 326
Cdd:PRK06739  238 GDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIES 317

                  ....
gi 1601809810 327 IRQM 330
Cdd:PRK06739  318 VSTL 321
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
5-457 1.21e-90

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 285.10  E-value: 1.21e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   5 KKTKIVATLGPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVMKGE- 83
Cdd:PLN02762   25 RRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLGGAs 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  84 -VIVNEGDEIIFaTGKRFEGTKER--VYMTYDSFPQDAKPGERILLDDGKLIFEVVstDK-KSEVKARVIQGGPLKSKKG 159
Cdd:PLN02762  105 sAKAEDGEEWTF-TVRKFDGSRPEftIQVNYDGFAEDVKVGDELVVDGGMVRFEVI--EKiGPDVKCKCTDPGLLLPRAN 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 160 VNL-------PNTNISQPALTEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHS-EHKIPIIAKIEKPEAVEN 231
Cdd:PLN02762  182 LTFwrdgslvRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSrDSDIGVIAKIESLDSLKN 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 232 IDKIVAYCDGLMVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAV 311
Cdd:PLN02762  262 LEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADAL 341
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 312 MLSGETSVGSYP---VQVIRQMANIIR--SVEDSPLIQVPQSPPHIRTKRYITKSICYHAAHMANEIDAKAISTLTNSGY 386
Cdd:PLN02762  342 MLSGESAMGLYPekaLSVLRSVSLRMElwSREEKRHEALELPQLSSSLSDRISEEICNSAAKMANNLGVDAIFVYTKHGH 421
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1601809810 387 TAFQISAWRPSSHILVFTSNKRILTQLSLLWGVKAFYYDKFVSTDETIEDVNAIACKKGYLETGDMLVSLA 457
Cdd:PLN02762  422 MASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSGDLVIAVS 492
PLN02765 PLN02765
pyruvate kinase
7-403 1.03e-57

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 199.13  E-value: 1.03e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   7 TKIVATLGPATSTKDVLKGMLEEGVDVFRINFS--HADY-----KDVEQRIKMIRELndefgynAAILGDLQGPKLRVGV 79
Cdd:PLN02765   30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSwgDAEYhqetlENLKIAVKNTKKL-------CAVMLDTVGPELQVIN 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  80 MKGEVI-VNEGDEIIFATGKRFEGTKERVYMTYDSFPQDAKPGERILLddGKLIF----------EVVSTDKKSEV---K 145
Cdd:PLN02765  103 KTEKPIsLKAGNTVTLTPDQSKEASSEVLPINFPGLAKAVKPGDTIFV--GQYLFtgsettsvwlEVDEVKGDDVVctvK 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 146 ARVIQGGPLKSkkgVNLPNTNISQPALTEKDIEdAI--FAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEHKIPIIAKI 223
Cdd:PLN02765  181 NSATLAGSLFT---LHVSQVRIDLPTLSEKDKE-VIstWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIFAKI 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 224 EKPEAVENIDKIVAYCDGLMVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIaTQMMETMISSLTPTRAEVNDVANS 303
Cdd:PLN02765  257 ENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANA 335
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 304 VMDGADAVMLSGETSVGSYPVQVIRQMANIIRSVEdspliQVPQSPPHI-RTKRYI------TKSICYHAAHMANEIDAK 376
Cdd:PLN02765  336 VLDGADAILLGAETLRGLYPVETISTVGRICAEAE-----KVFNQDLYFkKTVKYVgepmshLESIASSAVRAAIKVKAS 410
                         410       420
                  ....*....|....*....|....*..
gi 1601809810 377 AISTLTNSGYTAFQISAWRPSSHILVF 403
Cdd:PLN02765  411 VIIVFTSSGRAARLIAKYRPTMPVLSV 437
PRK08187 PRK08187
pyruvate kinase; Validated
2-313 7.13e-55

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 191.00  E-value: 7.13e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   2 PKRKKTKIVATL-GPATSTKDVLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVGVM 80
Cdd:PRK08187  130 PAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAV 209
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  81 ---KGEVIVNEGDEIIFATGKRFEGTKERVYMTYDSFPQ---DAKPGERILLDDGKLIFEVVSTDKkSEVKARVIQGGP- 153
Cdd:PRK08187  210 agpLGKTRLYTGDRLALVAQGPPRRIDEEHFQVTCTLPEilaRLAVGARVWIDDGKLGARVERVGP-GGALLEVTHARPk 288
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 154 ---LKSKKGVNLPNTNISQPALTEKDIEDAIFAIKmQVDWIALSFVRHAEDLIQLEELIKE---HSEHKIPIIAKIEKPE 227
Cdd:PRK08187  289 glkLKPEKGLNFPDTALDLPALTEKDRADLDFVAR-HADLVGYSFVQSPGDVEALQAALAArrpDDWRKLGLVLKIETPR 367
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 228 AVENIDKIVAYCDG-----LMVARGDLGVEIPAEEVPLIQKQLVLRAKRARIPVIIATQMMETMISSLTPTRAEVNDVAN 302
Cdd:PRK08187  368 AVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAM 447
                         330
                  ....*....|.
gi 1601809810 303 SvmDGADAVML 313
Cdd:PRK08187  448 A--ARAECVML 456
PRK14725 PRK14725
pyruvate kinase; Provisional
7-335 3.19e-50

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 180.53  E-value: 3.19e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810   7 TKIVATLgPATSTKD--VLKGMLEEGVDVFRINFSHADYKDVEQRIKMIRELNDEFGYNAAILGDLQGPKLRVG------ 78
Cdd:PRK14725  141 TRIMVTL-PTEAADDpdLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGpiapgp 219
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810  79 -VMK--------GEVI---------------------------------VNEGDEIIF--ATGKR--------------F 100
Cdd:PRK14725  220 rVIKlrptrdalGRVLtparlwltasespppspppgpvglpvdpewlarLEPGDELRFtdARGKKrkltvtevddegvlA 299
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 101 EGTK-----------------------------------ERVYMTYDSFP---------------------QDAKPGERI 124
Cdd:PRK14725  300 EGSQtaylangtllrlgrhdstrvgglppveqklrlkvgDRLVLTRDDAPgdpaqgdapparisctlpeafRAARVGERV 379
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 125 LLDDGKlIFEVVSTDKKSEVKARVIQGGP----LKSKKGVNLPNTNISQPALTEKDIEDAIFAIKmQVDWIALSFVRHAE 200
Cdd:PRK14725  380 WFDDGK-IGAVVVKVEADEVELRITHARPggskLKAGKGINLPDSHLPLPALTDKDLEDLAFVAK-HADIVALSFVRSPE 457
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 201 DLIQLEELIKEHSEHKIPIIAKIEKPEAVENIDKIV-----AYCDGLMVARGDLGVEIPAEEVPLIQKQLVLRAKRARIP 275
Cdd:PRK14725  458 DVRLLLDALEKLGADDLGVVLKIETRRAFENLPRILleamrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVP 537
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 276 VIIATQMMETMISSLTPTRAEVNDVANSVMdgADAVMLSGetsvGSYPVQVIRQMANIIR 335
Cdd:PRK14725  538 VIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLNK----GPHIVEAVRVLDDILR 591
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
268-472 1.45e-45

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 161.61  E-value: 1.45e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 268 RAKRARIPVIIATQMMETMISSLTPTRAEVNDVANSVMDGADAVMLSGETSVGSYPVQVIRQMANIIRSVEDSPLIQVPQ 347
Cdd:COG3848     1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 348 SPPHIRTKRYITKSICYHAAHMANEIDAKAISTLTNSGYTAFQISAWRPSSHILVFTSNKRILTQLSLLWGVKAFYYDKF 427
Cdd:COG3848    81 VPRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEES 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1601809810 428 VSTDETIEDVNAIACKKGYLETGDMLVSLAAMPIQEKGMVNTLRV 472
Cdd:COG3848   161 ASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKV 205
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
361-472 1.94e-37

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 132.99  E-value: 1.94e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 361 SICYHAAHMANEIDAKAISTLTNSGYTAFQISAWRPSSHILVFTSNKRILTQLSLLWGVKAFYYDKFVSTDETIEDVNAI 440
Cdd:pfam02887   2 AIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVKV 81
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1601809810 441 ACKKGYLETGDMLVSLAAMPIQEKGMVNTLRV 472
Cdd:pfam02887  82 AKEAGLVKKGDLVVITAGVPFGVSGTTNTLKV 113
CitE COG2301
Citrate lyase beta subunit [Carbohydrate transport and metabolism];
173-277 3.67e-07

Citrate lyase beta subunit [Carbohydrate transport and metabolism];


Pssm-ID: 441876  Cd Length: 288  Bit Score: 51.69  E-value: 3.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 173 TEKDIEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIK--EHSEHKIPIIAKIEKPEAVENIDKIVAYCDGLMVAR---- 246
Cdd:COG2301    74 TPWGLDDLAALVGAGLDGIVLPKVESAEDVRALAALLTelEAEGGSIPLMALIETARGLLNAAEIAAASPRVEALVfgae 153
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1601809810 247 ---GDLGVEIPAEEVPL--IQKQLVLRAKRARIPVI 277
Cdd:COG2301   154 dlaADLGARRTRDGDELlyARSRIVLAARAAGLAAI 189
HpcH_HpaI pfam03328
HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1, ...
177-277 1.33e-03

HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.


Pssm-ID: 427247 [Multi-domain]  Cd Length: 221  Bit Score: 40.03  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1601809810 177 IEDAIFAIKMQVDWIALSFVRHAEDLIQLEELIKEHSEH------KIPIIAKIEKPEAVENIDKIVAyCDGLM-VARG-- 247
Cdd:pfam03328  74 GKQDLAVLDLGAQVVLVPKVETAEDARAAVSAIRYPPKGirrangNTCLLAQIESALGVLNADEIAA-VEGVDgIFLGae 152
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1601809810 248 ----DLGVEIPAE--EVPLIQKQLVLRAKRARIPVI 277
Cdd:pfam03328 153 dlsaDLGTLRSPGgpEVLYARERIVTAARAAGIAAF 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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