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Conserved domains on  [gi|1603844008|ref|WP_134348956|]
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class I adenylate cyclase [Lelliottia nimipressuralis]

Protein Classification

class I adenylate cyclase( domain architecture ID 11459653)

class I adenylate cyclase catalyzes the conversion of ATP to cyclic AMP and pyrophosphate

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
CyaA COG3072
Adenylate cyclase, class I [Signal transduction mechanisms];
1-825 0e+00

Adenylate cyclase, class I [Signal transduction mechanisms];


:

Pssm-ID: 442306  Cd Length: 930  Bit Score: 1487.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008   1 MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPQGICLFTPDETQQHYLSELelY 80
Cdd:COG3072     7 MRKDLKTLRQRFLALNQLRLERALSAMSSRQQQVLDLLPLLFHYNHPLLPGYVSGDVPAGIANFTPDKRQLQALQRL--A 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008  81 RGMPPQESPKGELPITGVYSMGSTSSVGQSCSSDLDIWVCHQSWLDNEERQLLQRKCSLLESWAASLGVEVSFFLIDENR 160
Cdd:COG3072    85 RSFDYKQRAQHEPPILGLYLMGSTGSIAQSESSDLDIWVCHDPDLDAEARALLQQKCELIEQWAASLGVEVHFFLMDENR 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 161 FRHNESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILWNMVPCDEEEHYDDYVMSLYSQGVLTPNEWLDLGGLSSLSA 240
Cdd:COG3072   165 FRHGERESLSGENCGSAQHLLLLDEFYRTAILLAGKRPLWWLVPPEEEHNYDEYVQTLLAKGFINPDEWLDFGGLGTIPA 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 241 EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPTPRLLAKDIKQRLHDGEIVSFGLDAYCMMLERVTEYLKAIDDTT 320
Cdd:COG3072   245 EEYFGAGLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLEFKQAVYAGELDLDELDPYVMMLRRVTRYLLERNDLK 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 321 RLDLVRRCFYLKVCEKLSRE--RACVGWRREVVSQLVKEWGWDEERLSMLDNRANWKIDQVREAHNELLDAMMQSYRNLI 398
Cdd:COG3072   325 RLELVRRCFYLKVNEKLSRPprERSKSWRRELLERLVREWGWSEERLALLDNRAQWKIEQVREERNELVDELMQSYRNLI 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 399 RFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIYVPPGRANRTGWYLYNRAPSMDSIVS 478
Cdd:COG3072   405 QFARRNNISSSISPQDIGILGRKLYAAFERLPGKVTLINPGISPDLSEENLTFIQVPEGRANRAGWYLYNQSLTPADIIG 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 479 HQPLEYNRYLNKLVAWAWFNGLLTSRTRLFI-KGNEVVDLAKLQEMVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVN 557
Cdd:COG3072   485 RQPLKYSRSLVELVAWCYFNGLLTASTRLHLhPGGSDLDEYELQQLVADLRQHFPVPLPAPSNEALSRPCEIRHLALFIN 564
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 558 LEYDPTAAFRNQVVHFDFRKLDVFSFGEQQNCLVGSVDLLYRNSWNEVRTLHFNGEQAMIEALKTILGKMHQDAAPPDSV 637
Cdd:COG3072   565 LGVDPTAHLSRRGIHFDSSRSDALSFGGARENLVGSIDLVYRNSWNEVRTLHFEGDDALLDALKTLLGKMHQDAAPPPSI 644
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 638 EVFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQeTGRFKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHG 717
Cdd:COG3072   645 DVFCYSQTRRGAIANRVEQLFNECISLRLGGTRQ-PNRRYLLRVAGQYYGLFFERRGVSVQKLENAVDLYRALSENKLSY 723
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 718 LSVQVE---TNHVKLPQVVDGFASEGIIQFFFEESGDdaGFNIYILDETNRAEVYHHCEGSKEELVRDVSRFYSSSHDRF 794
Cdd:COG3072   724 SPLVLDrhaLEDHPLPPVIDSFASEGLIQFFFEDNGD--GFNIYILDENNSLEIYRQCEGDKEELLRPLNRFYRSSQDRR 801
                         810       820       830
                  ....*....|....*....|....*....|..
gi 1603844008 795 TYGSSFINFNLPQFYQIVNVD-GRTQVIPFRT 825
Cdd:COG3072   802 TYGSSFINFNLPQFYQIVRNDgGELQVEPFRS 833
 
Name Accession Description Interval E-value
CyaA COG3072
Adenylate cyclase, class I [Signal transduction mechanisms];
1-825 0e+00

Adenylate cyclase, class I [Signal transduction mechanisms];


Pssm-ID: 442306  Cd Length: 930  Bit Score: 1487.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008   1 MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPQGICLFTPDETQQHYLSELelY 80
Cdd:COG3072     7 MRKDLKTLRQRFLALNQLRLERALSAMSSRQQQVLDLLPLLFHYNHPLLPGYVSGDVPAGIANFTPDKRQLQALQRL--A 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008  81 RGMPPQESPKGELPITGVYSMGSTSSVGQSCSSDLDIWVCHQSWLDNEERQLLQRKCSLLESWAASLGVEVSFFLIDENR 160
Cdd:COG3072    85 RSFDYKQRAQHEPPILGLYLMGSTGSIAQSESSDLDIWVCHDPDLDAEARALLQQKCELIEQWAASLGVEVHFFLMDENR 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 161 FRHNESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILWNMVPCDEEEHYDDYVMSLYSQGVLTPNEWLDLGGLSSLSA 240
Cdd:COG3072   165 FRHGERESLSGENCGSAQHLLLLDEFYRTAILLAGKRPLWWLVPPEEEHNYDEYVQTLLAKGFINPDEWLDFGGLGTIPA 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 241 EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPTPRLLAKDIKQRLHDGEIVSFGLDAYCMMLERVTEYLKAIDDTT 320
Cdd:COG3072   245 EEYFGAGLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLEFKQAVYAGELDLDELDPYVMMLRRVTRYLLERNDLK 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 321 RLDLVRRCFYLKVCEKLSRE--RACVGWRREVVSQLVKEWGWDEERLSMLDNRANWKIDQVREAHNELLDAMMQSYRNLI 398
Cdd:COG3072   325 RLELVRRCFYLKVNEKLSRPprERSKSWRRELLERLVREWGWSEERLALLDNRAQWKIEQVREERNELVDELMQSYRNLI 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 399 RFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIYVPPGRANRTGWYLYNRAPSMDSIVS 478
Cdd:COG3072   405 QFARRNNISSSISPQDIGILGRKLYAAFERLPGKVTLINPGISPDLSEENLTFIQVPEGRANRAGWYLYNQSLTPADIIG 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 479 HQPLEYNRYLNKLVAWAWFNGLLTSRTRLFI-KGNEVVDLAKLQEMVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVN 557
Cdd:COG3072   485 RQPLKYSRSLVELVAWCYFNGLLTASTRLHLhPGGSDLDEYELQQLVADLRQHFPVPLPAPSNEALSRPCEIRHLALFIN 564
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 558 LEYDPTAAFRNQVVHFDFRKLDVFSFGEQQNCLVGSVDLLYRNSWNEVRTLHFNGEQAMIEALKTILGKMHQDAAPPDSV 637
Cdd:COG3072   565 LGVDPTAHLSRRGIHFDSSRSDALSFGGARENLVGSIDLVYRNSWNEVRTLHFEGDDALLDALKTLLGKMHQDAAPPPSI 644
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 638 EVFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQeTGRFKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHG 717
Cdd:COG3072   645 DVFCYSQTRRGAIANRVEQLFNECISLRLGGTRQ-PNRRYLLRVAGQYYGLFFERRGVSVQKLENAVDLYRALSENKLSY 723
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 718 LSVQVE---TNHVKLPQVVDGFASEGIIQFFFEESGDdaGFNIYILDETNRAEVYHHCEGSKEELVRDVSRFYSSSHDRF 794
Cdd:COG3072   724 SPLVLDrhaLEDHPLPPVIDSFASEGLIQFFFEDNGD--GFNIYILDENNSLEIYRQCEGDKEELLRPLNRFYRSSQDRR 801
                         810       820       830
                  ....*....|....*....|....*....|..
gi 1603844008 795 TYGSSFINFNLPQFYQIVNVD-GRTQVIPFRT 825
Cdd:COG3072   802 TYGSSFINFNLPQFYQIVRNDgGELQVEPFRS 833
cyaA PRK09450
class I adenylate cyclase;
1-830 0e+00

class I adenylate cyclase;


Pssm-ID: 236522 [Multi-domain]  Cd Length: 830  Bit Score: 1474.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008   1 MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPQGICLFTPDETQQHYLSELELY 80
Cdd:PRK09450    1 MRKYLETLKQRLDALNQLRLARALAALSPAFQQVLSLLPLLLHVNHPLLPGYVSGNTPAGICNFTPDETQLAYLQRLELS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008  81 RGMPPQESPKGELPITGVYSMGSTSSVGQSCSSDLDIWVCHQSWLDNEERQLLQRKCSLLESWAASLGVEVSFFLIDENR 160
Cdd:PRK09450   81 FGYSVQDPPKGELPITGLYTMGSTGSIGQSESSDLDIWVCHRPWLDAEERQLLQRKCSLLEQWAASLGVEVNFFLMDEER 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 161 FRHNESGS-LGGEDCGSTQHILLLDEFYRTAVRLAGKRILWNMVPCDEEEHYDDYVMSLYSQGVLTPNEWLDLGGLSSLS 239
Cdd:PRK09450  161 FRHNESGSaLGGEDCGSTQHILLLDEFYRTAIRLAGKRPLWWLVPVEEEEHYDDYVMTLYSKGFLNPNEWLDLGGLSSLP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 240 AEEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPTPRLLAKDIKQRLHDGEIVSFGLDAYCMMLERVTEYLKAIDDT 319
Cdd:PRK09450  241 AEEYFGASLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLDFKQRLLAGEIDSDGLDPYCLMLERVTRYLTAINDP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 320 TRLDLVRRCFYLKVCEKLSRERACVGWRREVVSQLVKEWGWDEERLSMLDNRANWKIDQVREAHNELLDAMMQSYRNLIR 399
Cdd:PRK09450  321 TRLELVRRCFYLKVGEKLSRERACVGWRRELLSQLVSEWGWDEERLALLDNRANWKIGQVREFHNELVDALMQSYRNLIR 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 400 FARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIYVPPGRANRTGWYLYNRAPSMDSIVSH 479
Cdd:PRK09450  401 FARRNNLSSSISPQDIGILTRKLYAAFERLPGKVTLLNPQISPDLSEPDLTFIEVPPGRANRSGWYLYNQAPDPDSIIGH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 480 QPLEYNRYLNKLVAWAWFNGLLTSRTRLFIKGNE-VVDLAKLQEMVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVNL 558
Cdd:PRK09450  481 QPLEYNRYLNKLVAWAYFNGLLTSSTRLHLKGNGsDLDLAKLQELVADLRQHFPLRLPAPTPQALLQPCEIRHLLIIVNL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 559 EYDPTAAFRNQVVHFDFRKLDVFSFGEQQNCLVGSVDLLYRNSWNEVRTLHFNGEQAMIEALKTILGKMHQDAAPPDSVE 638
Cdd:PRK09450  561 EVDPTAHLRGQVVHFDFRNLDVFSFGGEQENLVGSVDLIYRNSWNEVRTLHFEGEQALLDALKTILGKMHQDAAPPPSVE 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 639 VFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQETGrfKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHGL 718
Cdd:PRK09450  641 VFCYSQHLRGLIRTRVQQLVSECIELRLGSTRQEPG--KALRVAGQTWGLFFERLGVSVQKLENAVEFYGALSENKLHGL 718
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 719 SVQVETNHVKLPQVVDGFASEGIIQFFFEESGDdaGFNIYILDETNRAEVYHHCEGSKEELVRDVSRFYSSSHDRFTYGS 798
Cdd:PRK09450  719 PVQLDTNFLKLPAVVDGFASEGIIQFFFEDNED--GFNVYILDESNRLEHYHHCEGSKEELVRDVSRFYSSSHDRFTYGS 796
                         810       820       830
                  ....*....|....*....|....*....|..
gi 1603844008 799 SFINFNLPQFYQIVNVDGRTQVIPFRTQAVTP 830
Cdd:PRK09450  797 SFINFNLPQFYQLVRVDGRLQVIPFRSQLEEA 828
Adenylate_cycl pfam01295
Adenylate cyclase, class-I;
228-826 0e+00

Adenylate cyclase, class-I;


Pssm-ID: 426186  Cd Length: 601  Bit Score: 960.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 228 EWLDLGGLSSLSAEEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPTPRLLAKDIKQRLHDGEIVSFGLDAYCMMLE 307
Cdd:pfam01295   1 DWLDLGGLSALPAEEYFGASLWQLYKGIDSPYKAVLKILLLEAYSSEYPNTELLSSQFKRRLLAGDFTSYHLDPYLLMLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 308 RVTEYLKAIDDTTRLDLVRRCFYLKVCEKLSRE--RACVGWRREVVSQLVKEWGWDEERLSMLDNRANWKIDQVREAHNE 385
Cdd:pfam01295  81 RVTDYLTKINDFKRLDLVRRCFYLKAGEGLSRLqpNGAKDWRRDKLQELVQQWHWSDELIQTLDNRRHWKVGQVKWANNQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 386 LLDAMMQSYRNLIRFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIYVPPGRANRTGWY 465
Cdd:pfam01295 161 LLELLMLSYRNLIQFARKHNISESISPEDIGILTRKLYTAFEELPGKVTLLNPLISPDLSEPDLTFIEVPEGRSNKAGWY 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 466 LYNRAPSMDSIVSHQPLEYNRYLNKLVAWAWFNGLLTSRTRLFIKGNEV-VDLAKLQEMVADVSHHFPLRLPAPTPKALY 544
Cdd:pfam01295 241 LYNQPPDPADLIGRRPLEYAKYLSKLVAWAYFNGLLTESTRLHLVSQGVdLTSDKLSQFVTDLRLSFPVRAPKPTNQDLS 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 545 SPCEIRHLAIIVNLEYDPTAAFRNQVVHFDFRKLDVFSFGEQQNCLVGSVDLLYRNSWNEVRTLHFNGEQAMIEALKTIL 624
Cdd:pfam01295 321 HPCEIRHLVIFINLEQDPTTHWSGQEVMVDIQNADLFSFGRSQENLVGSVDLIYRNSWNEIRTLHFEGENALLKALKTIL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 625 GKMHQDAAPPDSVEVFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQETgRFKALRVSGQTWGLFFERLNVSVQKLENAI 704
Cdd:pfam01295 401 NKIHRDAAPPESIDVFCYSRRLRSQLRNAVKQLLNRCIELRLGTIQSRT-QVKPLRIGGKNYGLFFERRGVSVQDLENAV 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 705 EFYGAISHNKLHGLSVQV--ETNHVKLPQVVDGFASEGIIQFFFEESgdDAGFNIYILDETNRAEVYHHCEGSKEELVRD 782
Cdd:pfam01295 480 DFYGQISRNKLVELPRPElgDDPFLHIPAIIDAFASEGLIQFFFEDN--EDGFNVYILDEKNELEIYHQCDGSKDELVNE 557
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 1603844008 783 VSRFYSSSHDRFTYGSSFINFNLPQFYQIVNVDGRTQVIPFRTQ 826
Cdd:pfam01295 558 VNRFYASSESRKNTNPAFINFNLPQFYQLVRVNGELKVVPFRSS 601
 
Name Accession Description Interval E-value
CyaA COG3072
Adenylate cyclase, class I [Signal transduction mechanisms];
1-825 0e+00

Adenylate cyclase, class I [Signal transduction mechanisms];


Pssm-ID: 442306  Cd Length: 930  Bit Score: 1487.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008   1 MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPQGICLFTPDETQQHYLSELelY 80
Cdd:COG3072     7 MRKDLKTLRQRFLALNQLRLERALSAMSSRQQQVLDLLPLLFHYNHPLLPGYVSGDVPAGIANFTPDKRQLQALQRL--A 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008  81 RGMPPQESPKGELPITGVYSMGSTSSVGQSCSSDLDIWVCHQSWLDNEERQLLQRKCSLLESWAASLGVEVSFFLIDENR 160
Cdd:COG3072    85 RSFDYKQRAQHEPPILGLYLMGSTGSIAQSESSDLDIWVCHDPDLDAEARALLQQKCELIEQWAASLGVEVHFFLMDENR 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 161 FRHNESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILWNMVPCDEEEHYDDYVMSLYSQGVLTPNEWLDLGGLSSLSA 240
Cdd:COG3072   165 FRHGERESLSGENCGSAQHLLLLDEFYRTAILLAGKRPLWWLVPPEEEHNYDEYVQTLLAKGFINPDEWLDFGGLGTIPA 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 241 EEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPTPRLLAKDIKQRLHDGEIVSFGLDAYCMMLERVTEYLKAIDDTT 320
Cdd:COG3072   245 EEYFGAGLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLEFKQAVYAGELDLDELDPYVMMLRRVTRYLLERNDLK 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 321 RLDLVRRCFYLKVCEKLSRE--RACVGWRREVVSQLVKEWGWDEERLSMLDNRANWKIDQVREAHNELLDAMMQSYRNLI 398
Cdd:COG3072   325 RLELVRRCFYLKVNEKLSRPprERSKSWRRELLERLVREWGWSEERLALLDNRAQWKIEQVREERNELVDELMQSYRNLI 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 399 RFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIYVPPGRANRTGWYLYNRAPSMDSIVS 478
Cdd:COG3072   405 QFARRNNISSSISPQDIGILGRKLYAAFERLPGKVTLINPGISPDLSEENLTFIQVPEGRANRAGWYLYNQSLTPADIIG 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 479 HQPLEYNRYLNKLVAWAWFNGLLTSRTRLFI-KGNEVVDLAKLQEMVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVN 557
Cdd:COG3072   485 RQPLKYSRSLVELVAWCYFNGLLTASTRLHLhPGGSDLDEYELQQLVADLRQHFPVPLPAPSNEALSRPCEIRHLALFIN 564
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 558 LEYDPTAAFRNQVVHFDFRKLDVFSFGEQQNCLVGSVDLLYRNSWNEVRTLHFNGEQAMIEALKTILGKMHQDAAPPDSV 637
Cdd:COG3072   565 LGVDPTAHLSRRGIHFDSSRSDALSFGGARENLVGSIDLVYRNSWNEVRTLHFEGDDALLDALKTLLGKMHQDAAPPPSI 644
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 638 EVFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQeTGRFKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHG 717
Cdd:COG3072   645 DVFCYSQTRRGAIANRVEQLFNECISLRLGGTRQ-PNRRYLLRVAGQYYGLFFERRGVSVQKLENAVDLYRALSENKLSY 723
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 718 LSVQVE---TNHVKLPQVVDGFASEGIIQFFFEESGDdaGFNIYILDETNRAEVYHHCEGSKEELVRDVSRFYSSSHDRF 794
Cdd:COG3072   724 SPLVLDrhaLEDHPLPPVIDSFASEGLIQFFFEDNGD--GFNIYILDENNSLEIYRQCEGDKEELLRPLNRFYRSSQDRR 801
                         810       820       830
                  ....*....|....*....|....*....|..
gi 1603844008 795 TYGSSFINFNLPQFYQIVNVD-GRTQVIPFRT 825
Cdd:COG3072   802 TYGSSFINFNLPQFYQIVRNDgGELQVEPFRS 833
cyaA PRK09450
class I adenylate cyclase;
1-830 0e+00

class I adenylate cyclase;


Pssm-ID: 236522 [Multi-domain]  Cd Length: 830  Bit Score: 1474.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008   1 MYLYIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPQGICLFTPDETQQHYLSELELY 80
Cdd:PRK09450    1 MRKYLETLKQRLDALNQLRLARALAALSPAFQQVLSLLPLLLHVNHPLLPGYVSGNTPAGICNFTPDETQLAYLQRLELS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008  81 RGMPPQESPKGELPITGVYSMGSTSSVGQSCSSDLDIWVCHQSWLDNEERQLLQRKCSLLESWAASLGVEVSFFLIDENR 160
Cdd:PRK09450   81 FGYSVQDPPKGELPITGLYTMGSTGSIGQSESSDLDIWVCHRPWLDAEERQLLQRKCSLLEQWAASLGVEVNFFLMDEER 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 161 FRHNESGS-LGGEDCGSTQHILLLDEFYRTAVRLAGKRILWNMVPCDEEEHYDDYVMSLYSQGVLTPNEWLDLGGLSSLS 239
Cdd:PRK09450  161 FRHNESGSaLGGEDCGSTQHILLLDEFYRTAIRLAGKRPLWWLVPVEEEEHYDDYVMTLYSKGFLNPNEWLDLGGLSSLP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 240 AEEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPTPRLLAKDIKQRLHDGEIVSFGLDAYCMMLERVTEYLKAIDDT 319
Cdd:PRK09450  241 AEEYFGASLWQLYKGIDSPYKSVLKLLLLEAYSSEYPNTQLLSLDFKQRLLAGEIDSDGLDPYCLMLERVTRYLTAINDP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 320 TRLDLVRRCFYLKVCEKLSRERACVGWRREVVSQLVKEWGWDEERLSMLDNRANWKIDQVREAHNELLDAMMQSYRNLIR 399
Cdd:PRK09450  321 TRLELVRRCFYLKVGEKLSRERACVGWRRELLSQLVSEWGWDEERLALLDNRANWKIGQVREFHNELVDALMQSYRNLIR 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 400 FARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIYVPPGRANRTGWYLYNRAPSMDSIVSH 479
Cdd:PRK09450  401 FARRNNLSSSISPQDIGILTRKLYAAFERLPGKVTLLNPQISPDLSEPDLTFIEVPPGRANRSGWYLYNQAPDPDSIIGH 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 480 QPLEYNRYLNKLVAWAWFNGLLTSRTRLFIKGNE-VVDLAKLQEMVADVSHHFPLRLPAPTPKALYSPCEIRHLAIIVNL 558
Cdd:PRK09450  481 QPLEYNRYLNKLVAWAYFNGLLTSSTRLHLKGNGsDLDLAKLQELVADLRQHFPLRLPAPTPQALLQPCEIRHLLIIVNL 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 559 EYDPTAAFRNQVVHFDFRKLDVFSFGEQQNCLVGSVDLLYRNSWNEVRTLHFNGEQAMIEALKTILGKMHQDAAPPDSVE 638
Cdd:PRK09450  561 EVDPTAHLRGQVVHFDFRNLDVFSFGGEQENLVGSVDLIYRNSWNEVRTLHFEGEQALLDALKTILGKMHQDAAPPPSVE 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 639 VFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQETGrfKALRVSGQTWGLFFERLNVSVQKLENAIEFYGAISHNKLHGL 718
Cdd:PRK09450  641 VFCYSQHLRGLIRTRVQQLVSECIELRLGSTRQEPG--KALRVAGQTWGLFFERLGVSVQKLENAVEFYGALSENKLHGL 718
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 719 SVQVETNHVKLPQVVDGFASEGIIQFFFEESGDdaGFNIYILDETNRAEVYHHCEGSKEELVRDVSRFYSSSHDRFTYGS 798
Cdd:PRK09450  719 PVQLDTNFLKLPAVVDGFASEGIIQFFFEDNED--GFNVYILDESNRLEHYHHCEGSKEELVRDVSRFYSSSHDRFTYGS 796
                         810       820       830
                  ....*....|....*....|....*....|..
gi 1603844008 799 SFINFNLPQFYQIVNVDGRTQVIPFRTQAVTP 830
Cdd:PRK09450  797 SFINFNLPQFYQLVRVDGRLQVIPFRSQLEEA 828
Adenylate_cycl pfam01295
Adenylate cyclase, class-I;
228-826 0e+00

Adenylate cyclase, class-I;


Pssm-ID: 426186  Cd Length: 601  Bit Score: 960.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 228 EWLDLGGLSSLSAEEYFGASLWQLYKSIDSPYKAVLKTLLLEAYSWEYPTPRLLAKDIKQRLHDGEIVSFGLDAYCMMLE 307
Cdd:pfam01295   1 DWLDLGGLSALPAEEYFGASLWQLYKGIDSPYKAVLKILLLEAYSSEYPNTELLSSQFKRRLLAGDFTSYHLDPYLLMLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 308 RVTEYLKAIDDTTRLDLVRRCFYLKVCEKLSRE--RACVGWRREVVSQLVKEWGWDEERLSMLDNRANWKIDQVREAHNE 385
Cdd:pfam01295  81 RVTDYLTKINDFKRLDLVRRCFYLKAGEGLSRLqpNGAKDWRRDKLQELVQQWHWSDELIQTLDNRRHWKVGQVKWANNQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 386 LLDAMMQSYRNLIRFARRNNLSVSASPQDIGVLTRKLYAAFEALPGKVTLVNPQISPDLSEPNLTFIYVPPGRANRTGWY 465
Cdd:pfam01295 161 LLELLMLSYRNLIQFARKHNISESISPEDIGILTRKLYTAFEELPGKVTLLNPLISPDLSEPDLTFIEVPEGRSNKAGWY 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 466 LYNRAPSMDSIVSHQPLEYNRYLNKLVAWAWFNGLLTSRTRLFIKGNEV-VDLAKLQEMVADVSHHFPLRLPAPTPKALY 544
Cdd:pfam01295 241 LYNQPPDPADLIGRRPLEYAKYLSKLVAWAYFNGLLTESTRLHLVSQGVdLTSDKLSQFVTDLRLSFPVRAPKPTNQDLS 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 545 SPCEIRHLAIIVNLEYDPTAAFRNQVVHFDFRKLDVFSFGEQQNCLVGSVDLLYRNSWNEVRTLHFNGEQAMIEALKTIL 624
Cdd:pfam01295 321 HPCEIRHLVIFINLEQDPTTHWSGQEVMVDIQNADLFSFGRSQENLVGSVDLIYRNSWNEIRTLHFEGENALLKALKTIL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 625 GKMHQDAAPPDSVEVFCYSQHLRGLIRTRVQQLVSECIELRLSSTRQETgRFKALRVSGQTWGLFFERLNVSVQKLENAI 704
Cdd:pfam01295 401 NKIHRDAAPPESIDVFCYSRRLRSQLRNAVKQLLNRCIELRLGTIQSRT-QVKPLRIGGKNYGLFFERRGVSVQDLENAV 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008 705 EFYGAISHNKLHGLSVQV--ETNHVKLPQVVDGFASEGIIQFFFEESgdDAGFNIYILDETNRAEVYHHCEGSKEELVRD 782
Cdd:pfam01295 480 DFYGQISRNKLVELPRPElgDDPFLHIPAIIDAFASEGLIQFFFEDN--EDGFNVYILDEKNELEIYHQCDGSKDELVNE 557
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 1603844008 783 VSRFYSSSHDRFTYGSSFINFNLPQFYQIVNVDGRTQVIPFRTQ 826
Cdd:pfam01295 558 VNRFYASSESRKNTNPAFINFNLPQFYQLVRVNGELKVVPFRSS 601
Adenyl_cycl_N pfam12633
Adenylate cyclase NT domain;
4-200 6.23e-114

Adenylate cyclase NT domain;


Pssm-ID: 432684 [Multi-domain]  Cd Length: 198  Bit Score: 344.93  E-value: 6.23e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008   4 YIETLKQRLDAINQLRVDRALAAMGPAFQQVYSLLPTLLHYHHPLMPGYLDGNVPQGICLFTPDETQQHYLSELELYRGM 83
Cdd:pfam12633   1 DLETLRQRFDALNQLRLERALAALSPRQQQVLRLLPLLLHVNHPLLPGYVSGDTPCGIANFEPSKFQLALLDRLFRSFTY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1603844008  84 PPQESPKGELPITGVYSMGSTSSVGQSCSSDLDIWVCHQSWLDNEERQLLQRKCSLLESWAASLGVEVSFFLIDENRFRH 163
Cdd:pfam12633  81 KETKTDISDPPILGLYLMGSTGSIAQSASSDLDIWVCHRPGLDAEELELLQRKCQLIEQWAAQFGVEVHFFLMDPERFRS 160
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1603844008 164 NESGSLGGEDCGSTQHILLLDEFYRTAVRLAGKRILW 200
Cdd:pfam12633 161 NRSSSLTEESSGSAQHLLLLDEFYRTAIRLAGKRPLW 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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