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GNAT family N-acetyltransferase [Klebsiella variicola]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10456837)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  15581578|10940244|9175471|27367672|26818562
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 16-133 1.40e-15

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


:

Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 67.93  E-value: 1.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939  16 WLNLWEGYTRFYGSLQPEEVTECTWQRMLDVNSPVLgrVAVVDDTVVGFAICILHegtWVTTPICYLEDLFVDPAFRGQG 95
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFF--VAEEDGELVGFASLSII---DDEPPVGEIEGLAVAPEYRGKG 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1621035939  96 IARTIIKSLQTEGADKGWSRLYWHTRHDN-PARHLYDEF 133
Cdd:pfam00583  76 IGTALLQALLEWARERGCERIFLEVAADNlAAIALYEKL 114
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 16-133 1.40e-15

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 67.93  E-value: 1.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939  16 WLNLWEGYTRFYGSLQPEEVTECTWQRMLDVNSPVLgrVAVVDDTVVGFAICILHegtWVTTPICYLEDLFVDPAFRGQG 95
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFF--VAEEDGELVGFASLSII---DDEPPVGEIEGLAVAPEYRGKG 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1621035939  96 IARTIIKSLQTEGADKGWSRLYWHTRHDN-PARHLYDEF 133
Cdd:pfam00583  76 IGTALLQALLEWARERGCERIFLEVAADNlAAIALYEKL 114
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
3-130 5.36e-15

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 67.71  E-value: 5.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939   3 IDIREIRPHDKAEWLNLW-----EGYTRFYGSLQPEEVTECTWQRMLDVNSPVLgrVAVVDDTVVGFAICILHEgTWVTT 77
Cdd:COG1247     2 MTIRPATPEDAPAIAAIYneaiaEGTATFETEPPSEEEREAWFAAILAPGRPVL--VAEEDGEVVGFASLGPFR-PRPAY 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1621035939  78 PICYLEDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWHTRHDN-PARHLY 130
Cdd:COG1247    79 RGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNeASIALY 132
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 54-119 1.94e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 53.43  E-value: 1.94e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1621035939  54 VAVVDDTVVGFAICILHegtWVTTPICYLEDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWH 119
Cdd:cd04301     3 VAEDDGEIVGFASLSPD---GSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 54-130 2.50e-07

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 46.94  E-value: 2.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939  54 VAVVDDTVVGFAI--CILHEGTwvttpicyLEDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWHTRHDN-PARHLY 130
Cdd:TIGR01575  35 LARIGGKVVGYAGvqIVLDEAH--------ILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNiAAQALY 106
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 57-131 1.80e-06

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 44.53  E-value: 1.80e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1621035939  57 VDDTVVGFAIC--ILHEGTwvttpicyLEDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWHTRHDN-PARHLYD 131
Cdd:PRK09491   47 VNGQMAAFAITqvVLDEAT--------LFNIAVDPDYQRQGLGRALLEHLIDELEKRGVATLWLEVRASNaAAIALYE 116
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 16-133 1.40e-15

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 67.93  E-value: 1.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939  16 WLNLWEGYTRFYGSLQPEEVTECTWQRMLDVNSPVLgrVAVVDDTVVGFAICILHegtWVTTPICYLEDLFVDPAFRGQG 95
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFF--VAEEDGELVGFASLSII---DDEPPVGEIEGLAVAPEYRGKG 75

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1621035939  96 IARTIIKSLQTEGADKGWSRLYWHTRHDN-PARHLYDEF 133
Cdd:pfam00583  76 IGTALLQALLEWARERGCERIFLEVAADNlAAIALYEKL 114
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
3-130 5.36e-15

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 67.71  E-value: 5.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939   3 IDIREIRPHDKAEWLNLW-----EGYTRFYGSLQPEEVTECTWQRMLDVNSPVLgrVAVVDDTVVGFAICILHEgTWVTT 77
Cdd:COG1247     2 MTIRPATPEDAPAIAAIYneaiaEGTATFETEPPSEEEREAWFAAILAPGRPVL--VAEEDGEVVGFASLGPFR-PRPAY 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1621035939  78 PICYLEDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWHTRHDN-PARHLY 130
Cdd:COG1247    79 RGTAEESIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNeASIALY 132
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 63-142 1.48e-14

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 64.68  E-value: 1.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939  63 GFAICILHEGTwvttPICYLEDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWHTRHDN-PARHLYDE--FTPADDY 139
Cdd:COG0456     1 GFALLGLVDGG----DEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNeAAIALYEKlgFEEVGER 76


                  ...
gi 1621035939 140 VRY 142
Cdd:COG0456    77 PNY 79
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 3-137 1.85e-14

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 65.40  E-value: 1.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939   3 IDIREIRPHDKAEWLNLWEGYTRfygslqpEEVTECTWqrmldvnspvlgrVAVVDDTVVGFAICILHEGTwvttpICYL 82
Cdd:COG1246     1 MTIRPATPDDVPAILELIRPYAL-------EEEIGEFW-------------VAEEDGEIVGCAALHPLDED-----LAEL 55

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1621035939  83 EDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWHTRHdnPARHLYDE--FTPAD 137
Cdd:COG1246    56 RSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTS--AAIHFYEKlgFEEID 110
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 5-145 8.43e-14

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 63.92  E-value: 8.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939   5 IREIRPHDKAEWLnlwegytrfygslqPEEVTECTWQRMLDVNSPVLGRVAVVDDTVVGFA-ICILHEGTwvttpiCYLE 83
Cdd:COG0454     3 IRKATPEDINFIL--------------LIEALDAELKAMEGSLAGAEFIAVDDKGEPIGFAgLRRLDDKV------LELK 62

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1621035939  84 DLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWHT-RHDNPARHLYDE--FTPADDYVRYRIT 145
Cdd:COG0454    63 RLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTlDGNPAAIRFYERlgFKEIERYVAYVGG 127
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
5-130 1.96e-12

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 60.48  E-value: 1.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939   5 IREIRPHDKAEWLNLWEgytRFYGSLQPEEVTEctwqRMLDVNSPVLGRVAVVDDTVVGFaICILHEGTWVTTPICYLED 84
Cdd:COG3153     1 IRPATPEDAEAIAALLR---AAFGPGREAELVD----RLREDPAAGLSLVAEDDGEIVGH-VALSPVDIDGEGPALLLGP 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1621035939  85 LFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWHTrhDNPARHLY 130
Cdd:COG3153    73 LAVDPEYRGQGIGRALMRAALEAARERGARAVVLLG--DPSLLPFY 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 54-130 9.70e-11

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 54.77  E-value: 9.70e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1621035939  54 VAVVDDTVVGFAICILHEGTWVTtpicYLEDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWHTRhdNPARHLY 130
Cdd:pfam13508   7 VAEDDGKIVGFAALLPLDDEGAL----AELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETT--NRAAAFY 77
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 54-119 1.94e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 53.43  E-value: 1.94e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1621035939  54 VAVVDDTVVGFAICILHegtWVTTPICYLEDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWH 119
Cdd:cd04301     3 VAEDDGEIVGFASLSPD---GSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
61-145 2.45e-10

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 53.76  E-value: 2.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939  61 VVGFAICILHEGTWvttpiCYLEDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWHTRHDNP-ARHLYDE--FTPAD 137
Cdd:COG3393     2 LVAMAGVRAESPGV-----AEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPaARRLYERlgFRPVG 76


                  ....*...
gi 1621035939 138 DYVRYRIT 145
Cdd:COG3393    77 EYATVLFR 84
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 54-130 2.50e-07

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 46.94  E-value: 2.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939  54 VAVVDDTVVGFAI--CILHEGTwvttpicyLEDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWHTRHDN-PARHLY 130
Cdd:TIGR01575  35 LARIGGKVVGYAGvqIVLDEAH--------ILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSNiAAQALY 106
COG3818 COG3818
Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];
3-116 1.30e-06

Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 443030 [Multi-domain]  Cd Length: 168  Bit Score: 45.31  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939   3 IDIREIRPHDKAEWLNLWEGYTRFYGSLQPEEVTECtwqrmldVNSPVLGRVAVVDDTVVGFAICiLHEGT--------W 74
Cdd:COG3818     5 IVIRDAREHDLDAVLALNNAAVPAVSPLDAARLARL-------HEQAAYARVAEVDGEVAGFLLA-FGPGAdydspnyrW 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1621035939  75 V---TTPICYLEDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRL 116
Cdd:COG3818    77 FaerYDNFLYIDRIVVAPSARGRGLGRALYADVFSYARARGVPRV 121
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 21-107 1.43e-06

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 44.57  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939  21 EGYTRFYGSLQPEEVTectwQRMLDVNSPVLgrVAVVDDTVVGFaICILHEGtwvttpicYLEDLFVDPAFRGQGIARTI 100
Cdd:pfam13673   8 EGIETFYEFISPEALR----ERIDQGEYFFF--VAFEGGQIVGV-IALRDRG--------HISLLFVDPDYQGQGIGKAL 72


                  ....*..
gi 1621035939 101 IKSLQTE 107
Cdd:pfam13673  73 LEAVEDY 79
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 57-131 1.80e-06

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 44.53  E-value: 1.80e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1621035939  57 VDDTVVGFAIC--ILHEGTwvttpicyLEDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLYWHTRHDN-PARHLYD 131
Cdd:PRK09491   47 VNGQMAAFAITqvVLDEAT--------LFNIAVDPDYQRQGLGRALLEHLIDELEKRGVATLWLEVRASNaAAIALYE 116
PRK09831 PRK09831
GNAT family N-acetyltransferase;
34-104 1.19e-05

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 42.64  E-value: 1.19e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1621035939  34 EVTECTWQRMLdvnSPVLGRVAVVDDTVVGFAICILHegtwvttpicYLEDLFVDPAFRGQGIARTIIKSL 104
Cdd:PRK09831   40 QIDESRWKEKL---AKSQVRVAVINAQPVGFITCIEH----------YIDMLFVDPEYTRRGVASALLKPL 97
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 5-130 3.92e-04

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 38.44  E-value: 3.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939   5 IREIRPHDK---AEWLNLWEGYTRFYGSLQPEEVTECTWQRML-DVNSPVLGRVAVV---DDTVVGFaiCILHEGTWVTt 77
Cdd:COG1670    10 LRPLRPEDAealAELLNDPEVARYLPGPPYSLEEARAWLERLLaDWADGGALPFAIEdkeDGELIGV--VGLYDIDRAN- 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1621035939  78 PICYLeDLFVDPAFRGQGIARTIIKSLQTEGADK-GWSRLYWHTRHDN-PARHLY 130
Cdd:COG1670    87 RSAEI-GYWLAPAYWGKGYATEALRALLDYAFEElGLHRVEAEVDPDNtASIRVL 140
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
54-102 5.70e-04

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 36.67  E-value: 5.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1621035939  54 VAVVDDTVVGFAICILHEGTWVttpicyLEDLFVDPAFRGQGIARTIIK 102
Cdd:COG2388    13 ELEVDGELAGELTYRLEGGVII------ITHTEVPPALRGQGIASALVE 55
Eis COG4552
Predicted acetyltransferase [General function prediction only];
3-112 1.85e-03

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 37.19  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621035939   3 IDIREIRPHDKAEWLNLWEgytRFYGSLQPEEvtecTWQRMLDVNSPVLGRVAVVDDTVVGFAICILHEGTW--VTTPIC 80
Cdd:COG4552     1 MEIRPLTEDDLDAFARLLA---YAFGPEPDDE----ELEAYRPLLEPGRVLGVFDDGELVGTLALYPFTLNVggARVPMA 73

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1621035939  81 YLEDLFVDPAFRGQGIARTIIKSLQTEGADKG 112
Cdd:COG4552    74 GITGVAVAPEHRRRGVARALLREALAELRERG 105
PRK10514 PRK10514
putative acetyltransferase; Provisional
 54-102 2.83e-03

putative acetyltransferase; Provisional


Pssm-ID: 182510 [Multi-domain]  Cd Length: 145  Bit Score: 35.75  E-value: 2.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1621035939  54 VAVVD-DTVVGFAIciLHEGtwvttpicYLEDLFVDPAFRGQGIARTIIK 102
Cdd:PRK10514   53 VAVDErDQPVGFML--LSGG--------HMEALFVDPDVRGCGVGRMLVE 92
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
54-117 3.11e-03

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 35.55  E-value: 3.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1621035939  54 VAVVDDTVVGFA-ICILHEGTWvttpicYLEDLFVDPAFRGQGIARTIIKSLQTEGADKGWSRLY 117
Cdd:COG2153    38 LAYDDGELVATArLLPPGDGEA------KIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIV 96
DUF619-NAGS-FABP cd04266
DUF619 domain of N-acetylglutamate Synthase of the fungal arginine-biosynthetic pathway; ...
 63-132 8.60e-03

DUF619 domain of N-acetylglutamate Synthase of the fungal arginine-biosynthetic pathway; DUF619-NAGS-FABP: This family includes the DUF619 domain of N-acetylglutamate synthase (NAGS) of the fungal arginine-biosynthetic pathway (FABP). This NAGS (also known as arginine-requiring protein 2 or ARG2) consists of an N-terminal NAG kinase-like domain and a C-terminal DUF619 domain. NAGS catalyzes the formation of NAG from acetylcoenzyme A and L-glutamate. The DUF619 domain, yet to be characterized, is predicted to function in NAGS association in fungi.


Pssm-ID: 176268  Cd Length: 108  Bit Score: 33.97  E-value: 8.60e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1621035939  63 GFAICILhEGTWVTTP--ICYLEDLFVDPAFRGQ-GIARTIIKSLQtegaDKGWSRLYWHTRHDNPARHLYDE 132
Cdd:cd04266    22 GAAILTW-EGPDGSTPekIAYLDKFAVLPKAQGSdGIADILFNAML----DGFPNELIWRSRKDNPVNKWYFE 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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