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Conserved domains on  [gi|1621464490|ref|WP_136144348|]
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MULTISPECIES: metalloregulator ArsR/SmtB family transcription factor [Acinetobacter]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 16677510)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 5-79 6.61e-27

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


:

Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 94.06  E-value: 6.61e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1621464490   5 DFFKCLSDPTRLDILKLvMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLNPDLPEWAF 79
Cdd:NF033788    3 ELFKALADPTRLRILEL-LAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 5-79 6.61e-27

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 94.06  E-value: 6.61e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1621464490   5 DFFKCLSDPTRLDILKLvMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLNPDLPEWAF 79
Cdd:NF033788    3 ELFKALADPTRLRILEL-LAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 7-82 1.65e-26

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 94.50  E-value: 1.65e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1621464490   7 FKCLSDPTRLDILKLVMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLNPDLPEWAFAVL 82
Cdd:PRK10141   10 FKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWAAKII 85
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
4-82 2.43e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 90.72  E-value: 2.43e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1621464490   4 TDFFKCLSDPTRLDILKLvMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLNPDLPEWAFAVL 82
Cdd:COG0640    11 AELFKALADPTRLRILRL-LAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWL 88
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 7-73 1.61e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 78.11  E-value: 1.61e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1621464490   7 FKCLSDPTRLDILKLvMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLNPD 73
Cdd:cd00090     1 LKALSDPTRLRILRL-LLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA 66
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 7-71 5.97e-16

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 66.28  E-value: 5.97e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1621464490   7 FKCLSDPTRLDILKLvMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLN 71
Cdd:NF033789    2 FKALSDPTRREILEL-LKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLN 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
17-73 2.12e-15

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.54  E-value: 2.12e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1621464490   17 DILKLvMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLNPD 73
Cdd:smart00418   1 KILKL-LAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDE 56
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 12-57 5.34e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 55.53  E-value: 5.34e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1621464490  12 DPTRLDILKLvMAQHNICVCELTEQLQLNQPKISRHLALLRNLSIL 57
Cdd:pfam01022   1 DPTRLKILKL-LAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 5-79 6.61e-27

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 94.06  E-value: 6.61e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1621464490   5 DFFKCLSDPTRLDILKLvMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLNPDLPEWAF 79
Cdd:NF033788    3 ELFKALADPTRLRILEL-LAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 7-82 1.65e-26

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 94.50  E-value: 1.65e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1621464490   7 FKCLSDPTRLDILKLVMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLNPDLPEWAFAVL 82
Cdd:PRK10141   10 FKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRLSPHIPAWAAKII 85
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
4-82 2.43e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 90.72  E-value: 2.43e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1621464490   4 TDFFKCLSDPTRLDILKLvMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLNPDLPEWAFAVL 82
Cdd:COG0640    11 AELFKALADPTRLRILRL-LAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWL 88
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 7-73 1.61e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 78.11  E-value: 1.61e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1621464490   7 FKCLSDPTRLDILKLvMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLNPD 73
Cdd:cd00090     1 LKALSDPTRLRILRL-LLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA 66
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 7-71 5.97e-16

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 66.28  E-value: 5.97e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1621464490   7 FKCLSDPTRLDILKLvMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLN 71
Cdd:NF033789    2 FKALSDPTRREILEL-LKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSLN 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
17-73 2.12e-15

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 64.54  E-value: 2.12e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1621464490   17 DILKLvMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLNPD 73
Cdd:smart00418   1 KILKL-LAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDE 56
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 12-57 5.34e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 55.53  E-value: 5.34e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1621464490  12 DPTRLDILKLvMAQHNICVCELTEQLQLNQPKISRHLALLRNLSIL 57
Cdd:pfam01022   1 DPTRLKILKL-LAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
5-78 9.77e-08

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 46.18  E-value: 9.77e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1621464490   5 DFFKCLSDPTRLDILKLVmAQHNICVCELTEQLQLNQPKISRHLALLRNLSIL-----LDQRQGQWVYYRLNPDLPEWA 78
Cdd:COG1777     9 RLLDALGNPTRRRILALL-SEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVesyreGREDGRARKYYRLSAFRLEVT 86
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 5-64 2.25e-07

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 44.07  E-value: 2.25e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1621464490   5 DFFKCLSDPTRLDILKLVMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQ 64
Cdd:pfam12840   2 DVAEALADPTRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
7-52 1.01e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 40.71  E-value: 1.01e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1621464490   7 FKCLSDPTRLDILKLVmAQHNICVCELTEQLQLNQPKISRHLALLR 52
Cdd:COG4189    13 LKALASETRLRILRLL-AEEPLNVNELAEALGLPKSTVSYHIRKLE 57
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
7-73 1.06e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 38.71  E-value: 1.06e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1621464490   7 FKCLSDPTRLDILKLVMAQHNICVCELTEQLQLNQPKISRHLALLRNLSILLDQRQGQWVYYRLNPD 73
Cdd:COG3398    91 LAYLRRETPRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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