|
Name |
Accession |
Description |
Interval |
E-value |
| GlyA |
COG0112 |
Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine ... |
23-430 |
3.79e-93 |
|
Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine hydroxymethyltransferase is part of the Pathway/BioSystem: Serine biosynthesis
Pssm-ID: 439882 Cd Length: 414 Bit Score: 287.31 E-value: 3.79e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 23 STSKELYQKLRALIERHETvRVKTGINLVAAEGPMSLQARGLLSCDLGSRASGGSIGRnnRFFTGLDQADEIEALCIVLL 102
Cdd:COG0112 3 SSLAEVDPEIAEAIEKELE-RQEEGIELIASENFVSPAVLEAQGSVLTNKYAEGYPGK--RYYGGCEYVDEVEQLAIERA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 103 KELFECNHADPRLLGGLHANTVVY-AVLKnhfnVSD-ISTLNTFYGGNSSNHSLGPPGILNYSISDLPVDPNTLEIDLNA 180
Cdd:COG0112 80 KELFGAEHANVQPHSGSQANLAVYfALLK----PGDtILGMDLAHGGHLTHGSPVNFSGKGYNVVSYGVDPETGLIDYDE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 181 FEYMAKFRQPKLVSLGSGLNLFPFPVKEIKDIISRWGGMLLFDGSHQAGLIAGGVYPNPLSlGADIYTASTGKTFSGPQG 260
Cdd:COG0112 156 VRKLALEHKPKLIIAGASAYPRPIDFARFREIADEVGAYLMVDMAHIAGLVAGGLHPSPVP-GADVVTTTTHKTLRGPRG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 261 GVICWNsEKFSSPISTTIFPKLTGSHQLNRIAALTVSCLELKEYGL-EYMAQGILNARQLASNLQAHGLEVLCsdeGFTE 339
Cdd:COG0112 235 GLILCN-EELAKKIDSAVFPGLQGGPLMHVIAAKAVAFKEALTPEFkEYAKQVVKNAKALAEALAERGFRVVS---GGTD 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 340 THQVVVKWTR-EEGARLACYRLADVGVFANAVPLPEDRE---LLSGIRFGATEITRLGITQSQIVVLAEVIAGVLQGNYN 415
Cdd:COG0112 311 NHLVLVDLRSkGLTGKEAEKALERAGITVNKNAIPFDPRspfVTSGIRIGTPAVTTRGMKEAEMEEIAELIADVLDNPED 390
|
410
....*....|....*...
gi 1634387221 416 ---LKEARNVVSELASTF 430
Cdd:COG0112 391 eavLAEVREEVKELCKRF 408
|
|
| SHMT |
cd00378 |
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate ... |
31-427 |
2.78e-73 |
|
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl group of N5, N10-methylene tetrahydrofolate to glycine resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers; the mammalian enzyme forms a homotetramer comprising four pyridoxal phosphate-bound active sites.
Pssm-ID: 99733 Cd Length: 402 Bit Score: 235.56 E-value: 2.78e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 31 KLRALIErHETVRVKTGINLVAAEGPMSLQARGLLSCDLGSRASGGSIGRnnRFFTGLDQADEIEALCIVLLKELFECNH 110
Cdd:cd00378 6 EIAEIIK-KENERQRETLELIASENFTSPAVMEAMGSDLTNKYAEGYPGK--RYYGGCEYVDEIEDLAIERAKKLFGAEY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 111 ADPRLLGGLHANTVVY-AVLKNHfnvSDISTLNTFYGGNSSNHSLGPPGILNYSISDLP--VDPNTLEIDLNAFEYMAKF 187
Cdd:cd00378 83 ANVQPHSGSQANLAVYfALLEPG---DTIMGLDLSHGGHLTHGSFTKVSASGKLFESVPygVDPETGLIDYDALEKMALE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 188 RQPKLVSLGSGLNLFPFPVKEIKDIISRWGGMLLFDGSHQAGLIAGGVYPNPLsLGADIYTASTGKTFSGPQGGVICWNS 267
Cdd:cd00378 160 FKPKLIVAGASAYPRPIDFKRFREIADEVGAYLLVDMAHVAGLVAGGVFPNPL-PGADVVTTTTHKTLRGPRGGLILTRK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 268 EKFSSPISTTIFPKLTGSHQLNRIAALTVSCLE-LKEYGLEYMAQGILNARQLASNLQAHGLEVLCSDegfTETHQVVVK 346
Cdd:cd00378 239 GELAKKINSAVFPGLQGGPHLHVIAAKAVALKEaLEPEFKAYAKQVVENAKALAEALKERGFKVVSGG---TDNHLVLVD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 347 wTREEGA--RLACYRLADVGVFANAVPLPEDRE---LLSGIRFGATEITRLGITQSQIVVLAEVIAGVLqgnyNLKEARN 421
Cdd:cd00378 316 -LRPKGItgKAAEDALEEAGITVNKNTLPWDPSspfVPSGIRIGTPAMTTRGMGEEEMEEIADFIARAL----KDAEDVA 390
|
....*.
gi 1634387221 422 VVSELA 427
Cdd:cd00378 391 VAEEVR 396
|
|
| glyA |
PRK00011 |
serine hydroxymethyltransferase; Reviewed |
31-436 |
2.46e-72 |
|
serine hydroxymethyltransferase; Reviewed
Pssm-ID: 234571 Cd Length: 416 Bit Score: 233.43 E-value: 2.46e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 31 KLRALIErHETVRVKTGINLVAAEGPMSLQARGLLSCDLGSRASGGSIGRnnRFFTGLDQADEIEALCIVLLKELFECNH 110
Cdd:PRK00011 12 EIADAIE-QELKRQEEHIELIASENFVSPAVMEAQGSVLTNKYAEGYPGK--RYYGGCEYVDVVEQLAIDRAKELFGAEY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 111 ADPRLLGGLHANTVVY-AVLKNHfnvsD-ISTLNTFYGGNSSNHSLGPPGILNYSISDLPVDPNTLEIDLNAFEYMAKFR 188
Cdd:PRK00011 89 ANVQPHSGSQANAAVYfALLKPG----DtILGMDLAHGGHLTHGSPVNFSGKLYNVVSYGVDEETGLIDYDEVEKLALEH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 189 QPKLVSLGSGLNLFPFPVKEIKDIISRWGGMLLFDGSHQAGLIAGGVYPNPLSlGADIYTASTGKTFSGPQGGVICWNSE 268
Cdd:PRK00011 165 KPKLIIAGASAYSRPIDFKRFREIADEVGAYLMVDMAHIAGLVAAGVHPSPVP-HADVVTTTTHKTLRGPRGGLILTNDE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 269 KFSSPISTTIFPKLTGSHQLNRIAALTVSCLELKEYGL-EYMAQGILNARQLASNLQAHGLEVLCsdeGFTETHQVVVKW 347
Cdd:PRK00011 244 ELAKKINSAVFPGIQGGPLMHVIAAKAVAFKEALEPEFkEYAQQVVKNAKALAEALAERGFRVVS---GGTDNHLVLVDL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 348 T-REEGARLACYRLADVGVFAN--AVPL-PEDRELLSGIRFGATEITRLGITQSQIVVLAEVIAGVLQGNYN---LKEAR 420
Cdd:PRK00011 321 RsKGLTGKEAEAALEEANITVNknAVPFdPRSPFVTSGIRIGTPAITTRGFKEAEMKEIAELIADVLDNPDDeavIEEVK 400
|
410
....*....|....*.
gi 1634387221 421 NVVSELASTFSGFKYS 436
Cdd:PRK00011 401 EEVKELCKRFPLYKYL 416
|
|
| SHMT |
pfam00464 |
Serine hydroxymethyltransferase; |
36-406 |
2.20e-35 |
|
Serine hydroxymethyltransferase;
Pssm-ID: 395372 Cd Length: 399 Bit Score: 135.26 E-value: 2.20e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 36 IERHETVRVKTGINLVAAEGPMS---LQARGllSCdLGSRASGGSIGRnnRFFTGLDQADEIEALCIVLLKELFecnHAD 112
Cdd:pfam00464 11 IIKKEKERQREGIELIASENFTSravMEALG--SV-LTNKYSEGYPGK--RYYGGCEHVDEIETLCQDRALEAF---GLD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 113 PRLLG-------GLHANTVVY-AVLKNH-----FNVSDISTLNtfYGGNSSNHSLGPPGILnYSISDLPVDPNTLEIDLN 179
Cdd:pfam00464 83 PAKWGvnvqplsGSPANLAVYtALLEPGdrimgLDLPHGGHLT--HGYPVNSKKISASSKF-FESMPYGVDPETGYIDYD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 180 AFEYMAKFRQPKLVSLGSGLNLFPFPVKEIKDIISRWGGMLLFDGSHQAGLIAGGVYPNPLSLgADIYTASTGKTFSGPQ 259
Cdd:pfam00464 160 QLEKNAKLFRPKLIVAGTSAYSRLIDYARFREIADEVGAYLMVDMAHISGLVAAGVIPSPFPY-ADVVTTTTHKTLRGPR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 260 GGVICWN-------------SEKFSSPISTTIFPKLTGSHQLNRIAALTVS-----CLELKEYGLeymaQGILNARQLAS 321
Cdd:pfam00464 239 GGMIFYRkgvksvdktgkeiLYELEKKINSAVFPGLQGGPHNHVIAAKAVAlkqalTPEFKEYQQ----QVVKNAKALAE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 322 NLQAHGLEVLcsdEGFTETHQVVVKWTREE--GARlACYRLADVGVFANAVPLPEDRELL--SGIRFGATEITRLGITQS 397
Cdd:pfam00464 315 ALTERGYKLV---SGGTDNHLVLVDLRPKGldGAR-AEKVLEAANITANKNTIPGDKSAFvpSGLRLGTPALTSRGFGEA 390
|
....*....
gi 1634387221 398 QIVVLAEVI 406
Cdd:pfam00464 391 DFEKVAGFI 399
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GlyA |
COG0112 |
Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine ... |
23-430 |
3.79e-93 |
|
Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Glycine/serine hydroxymethyltransferase is part of the Pathway/BioSystem: Serine biosynthesis
Pssm-ID: 439882 Cd Length: 414 Bit Score: 287.31 E-value: 3.79e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 23 STSKELYQKLRALIERHETvRVKTGINLVAAEGPMSLQARGLLSCDLGSRASGGSIGRnnRFFTGLDQADEIEALCIVLL 102
Cdd:COG0112 3 SSLAEVDPEIAEAIEKELE-RQEEGIELIASENFVSPAVLEAQGSVLTNKYAEGYPGK--RYYGGCEYVDEVEQLAIERA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 103 KELFECNHADPRLLGGLHANTVVY-AVLKnhfnVSD-ISTLNTFYGGNSSNHSLGPPGILNYSISDLPVDPNTLEIDLNA 180
Cdd:COG0112 80 KELFGAEHANVQPHSGSQANLAVYfALLK----PGDtILGMDLAHGGHLTHGSPVNFSGKGYNVVSYGVDPETGLIDYDE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 181 FEYMAKFRQPKLVSLGSGLNLFPFPVKEIKDIISRWGGMLLFDGSHQAGLIAGGVYPNPLSlGADIYTASTGKTFSGPQG 260
Cdd:COG0112 156 VRKLALEHKPKLIIAGASAYPRPIDFARFREIADEVGAYLMVDMAHIAGLVAGGLHPSPVP-GADVVTTTTHKTLRGPRG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 261 GVICWNsEKFSSPISTTIFPKLTGSHQLNRIAALTVSCLELKEYGL-EYMAQGILNARQLASNLQAHGLEVLCsdeGFTE 339
Cdd:COG0112 235 GLILCN-EELAKKIDSAVFPGLQGGPLMHVIAAKAVAFKEALTPEFkEYAKQVVKNAKALAEALAERGFRVVS---GGTD 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 340 THQVVVKWTR-EEGARLACYRLADVGVFANAVPLPEDRE---LLSGIRFGATEITRLGITQSQIVVLAEVIAGVLQGNYN 415
Cdd:COG0112 311 NHLVLVDLRSkGLTGKEAEKALERAGITVNKNAIPFDPRspfVTSGIRIGTPAVTTRGMKEAEMEEIAELIADVLDNPED 390
|
410
....*....|....*...
gi 1634387221 416 ---LKEARNVVSELASTF 430
Cdd:COG0112 391 eavLAEVREEVKELCKRF 408
|
|
| SHMT |
cd00378 |
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate ... |
31-427 |
2.78e-73 |
|
Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl group of N5, N10-methylene tetrahydrofolate to glycine resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers; the mammalian enzyme forms a homotetramer comprising four pyridoxal phosphate-bound active sites.
Pssm-ID: 99733 Cd Length: 402 Bit Score: 235.56 E-value: 2.78e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 31 KLRALIErHETVRVKTGINLVAAEGPMSLQARGLLSCDLGSRASGGSIGRnnRFFTGLDQADEIEALCIVLLKELFECNH 110
Cdd:cd00378 6 EIAEIIK-KENERQRETLELIASENFTSPAVMEAMGSDLTNKYAEGYPGK--RYYGGCEYVDEIEDLAIERAKKLFGAEY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 111 ADPRLLGGLHANTVVY-AVLKNHfnvSDISTLNTFYGGNSSNHSLGPPGILNYSISDLP--VDPNTLEIDLNAFEYMAKF 187
Cdd:cd00378 83 ANVQPHSGSQANLAVYfALLEPG---DTIMGLDLSHGGHLTHGSFTKVSASGKLFESVPygVDPETGLIDYDALEKMALE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 188 RQPKLVSLGSGLNLFPFPVKEIKDIISRWGGMLLFDGSHQAGLIAGGVYPNPLsLGADIYTASTGKTFSGPQGGVICWNS 267
Cdd:cd00378 160 FKPKLIVAGASAYPRPIDFKRFREIADEVGAYLLVDMAHVAGLVAGGVFPNPL-PGADVVTTTTHKTLRGPRGGLILTRK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 268 EKFSSPISTTIFPKLTGSHQLNRIAALTVSCLE-LKEYGLEYMAQGILNARQLASNLQAHGLEVLCSDegfTETHQVVVK 346
Cdd:cd00378 239 GELAKKINSAVFPGLQGGPHLHVIAAKAVALKEaLEPEFKAYAKQVVENAKALAEALKERGFKVVSGG---TDNHLVLVD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 347 wTREEGA--RLACYRLADVGVFANAVPLPEDRE---LLSGIRFGATEITRLGITQSQIVVLAEVIAGVLqgnyNLKEARN 421
Cdd:cd00378 316 -LRPKGItgKAAEDALEEAGITVNKNTLPWDPSspfVPSGIRIGTPAMTTRGMGEEEMEEIADFIARAL----KDAEDVA 390
|
....*.
gi 1634387221 422 VVSELA 427
Cdd:cd00378 391 VAEEVR 396
|
|
| glyA |
PRK00011 |
serine hydroxymethyltransferase; Reviewed |
31-436 |
2.46e-72 |
|
serine hydroxymethyltransferase; Reviewed
Pssm-ID: 234571 Cd Length: 416 Bit Score: 233.43 E-value: 2.46e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 31 KLRALIErHETVRVKTGINLVAAEGPMSLQARGLLSCDLGSRASGGSIGRnnRFFTGLDQADEIEALCIVLLKELFECNH 110
Cdd:PRK00011 12 EIADAIE-QELKRQEEHIELIASENFVSPAVMEAQGSVLTNKYAEGYPGK--RYYGGCEYVDVVEQLAIDRAKELFGAEY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 111 ADPRLLGGLHANTVVY-AVLKNHfnvsD-ISTLNTFYGGNSSNHSLGPPGILNYSISDLPVDPNTLEIDLNAFEYMAKFR 188
Cdd:PRK00011 89 ANVQPHSGSQANAAVYfALLKPG----DtILGMDLAHGGHLTHGSPVNFSGKLYNVVSYGVDEETGLIDYDEVEKLALEH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 189 QPKLVSLGSGLNLFPFPVKEIKDIISRWGGMLLFDGSHQAGLIAGGVYPNPLSlGADIYTASTGKTFSGPQGGVICWNSE 268
Cdd:PRK00011 165 KPKLIIAGASAYSRPIDFKRFREIADEVGAYLMVDMAHIAGLVAAGVHPSPVP-HADVVTTTTHKTLRGPRGGLILTNDE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 269 KFSSPISTTIFPKLTGSHQLNRIAALTVSCLELKEYGL-EYMAQGILNARQLASNLQAHGLEVLCsdeGFTETHQVVVKW 347
Cdd:PRK00011 244 ELAKKINSAVFPGIQGGPLMHVIAAKAVAFKEALEPEFkEYAQQVVKNAKALAEALAERGFRVVS---GGTDNHLVLVDL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 348 T-REEGARLACYRLADVGVFAN--AVPL-PEDRELLSGIRFGATEITRLGITQSQIVVLAEVIAGVLQGNYN---LKEAR 420
Cdd:PRK00011 321 RsKGLTGKEAEAALEEANITVNknAVPFdPRSPFVTSGIRIGTPAITTRGFKEAEMKEIAELIADVLDNPDDeavIEEVK 400
|
410
....*....|....*.
gi 1634387221 421 NVVSELASTFSGFKYS 436
Cdd:PRK00011 401 EEVKELCKRFPLYKYL 416
|
|
| PRK13034 |
PRK13034 |
serine hydroxymethyltransferase; Reviewed |
32-430 |
3.17e-36 |
|
serine hydroxymethyltransferase; Reviewed
Pssm-ID: 237280 Cd Length: 416 Bit Score: 137.78 E-value: 3.17e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 32 LRALIERhETVRVKTGINLVAAEG---PMSLQARGllSCdLGSRASGGSIGRnnRFFTGLDQADEIEALCIVLLKELFEC 108
Cdd:PRK13034 16 VFAAINK-ELERQQDHLELIASENftsPAVMEAQG--SV-LTNKYAEGYPGK--RYYGGCEFVDEVEALAIERAKQLFGC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 109 NHADPRLLGGLHANTVVYAVLknhFNVSD-ISTLNTFYGG--------NSSNHslgppgilNYSISDLPVDPNTLEIDLN 179
Cdd:PRK13034 90 DYANVQPHSGSQANGAVYLAL---LKPGDtILGMSLSHGGhlthgakvSLSGK--------WYNAVQYGVDRLTGLIDYD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 180 AFEYMAKFRQPKLVSlgSGLNLFP----FP-VKEIKDIIsrwGGMLLFDGSHQAGLIAGGVYPNPLSLgADIYTASTGKT 254
Cdd:PRK13034 159 EVEELAKEHKPKLII--AGFSAYPreldFArFREIADEV---GALLMVDMAHIAGLVAAGEHPNPFPH-AHVVTTTTHKT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 255 FSGPQGGVICWNSEKFSSPISTTIFPKLTGSHQLNRIAALTVSCLE-LKEYGLEYMAQGILNARQLASNLQAHGLEVLcs 333
Cdd:PRK13034 233 LRGPRGGMILTNDEEIAKKINSAVFPGLQGGPLMHVIAAKAVAFGEaLQPEFKTYAKQVIANAQALAEVLKERGYDLV-- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 334 dEGFTETHQVVVKWTREE-GARLACYRLADVGVFANAVPLPEDRE---LLSGIRFGATEITRLGITQSQIVVLAEVIAGV 409
Cdd:PRK13034 311 -SGGTDNHLLLVDLRPKGlSGKDAEQALERAGITVNKNTVPGDTEspfVTSGIRIGTPAGTTRGFGEAEFREIANWILDV 389
|
410 420
....*....|....*....|....
gi 1634387221 410 LQGNYN---LKEARNVVSELASTF 430
Cdd:PRK13034 390 LDDLGNaalEQRVRKEVKALCSRF 413
|
|
| SHMT |
pfam00464 |
Serine hydroxymethyltransferase; |
36-406 |
2.20e-35 |
|
Serine hydroxymethyltransferase;
Pssm-ID: 395372 Cd Length: 399 Bit Score: 135.26 E-value: 2.20e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 36 IERHETVRVKTGINLVAAEGPMS---LQARGllSCdLGSRASGGSIGRnnRFFTGLDQADEIEALCIVLLKELFecnHAD 112
Cdd:pfam00464 11 IIKKEKERQREGIELIASENFTSravMEALG--SV-LTNKYSEGYPGK--RYYGGCEHVDEIETLCQDRALEAF---GLD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 113 PRLLG-------GLHANTVVY-AVLKNH-----FNVSDISTLNtfYGGNSSNHSLGPPGILnYSISDLPVDPNTLEIDLN 179
Cdd:pfam00464 83 PAKWGvnvqplsGSPANLAVYtALLEPGdrimgLDLPHGGHLT--HGYPVNSKKISASSKF-FESMPYGVDPETGYIDYD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 180 AFEYMAKFRQPKLVSLGSGLNLFPFPVKEIKDIISRWGGMLLFDGSHQAGLIAGGVYPNPLSLgADIYTASTGKTFSGPQ 259
Cdd:pfam00464 160 QLEKNAKLFRPKLIVAGTSAYSRLIDYARFREIADEVGAYLMVDMAHISGLVAAGVIPSPFPY-ADVVTTTTHKTLRGPR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 260 GGVICWN-------------SEKFSSPISTTIFPKLTGSHQLNRIAALTVS-----CLELKEYGLeymaQGILNARQLAS 321
Cdd:pfam00464 239 GGMIFYRkgvksvdktgkeiLYELEKKINSAVFPGLQGGPHNHVIAAKAVAlkqalTPEFKEYQQ----QVVKNAKALAE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 322 NLQAHGLEVLcsdEGFTETHQVVVKWTREE--GARlACYRLADVGVFANAVPLPEDRELL--SGIRFGATEITRLGITQS 397
Cdd:pfam00464 315 ALTERGYKLV---SGGTDNHLVLVDLRPKGldGAR-AEKVLEAANITANKNTIPGDKSAFvpSGLRLGTPALTSRGFGEA 390
|
....*....
gi 1634387221 398 QIVVLAEVI 406
Cdd:pfam00464 391 DFEKVAGFI 399
|
|
| PTZ00094 |
PTZ00094 |
serine hydroxymethyltransferase; Provisional |
26-430 |
6.59e-34 |
|
serine hydroxymethyltransferase; Provisional
Pssm-ID: 240264 Cd Length: 452 Bit Score: 132.03 E-value: 6.59e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 26 KELYQklraLIERhETVRVKTGINLVAAEGPMSLQARGLLSCDLGSRASGGSIGrnNRFFTGLDQADEIEALCIVLLKEL 105
Cdd:PTZ00094 20 PELYE----LIEK-EKERQIEGLELIASENFTSRAVLECLGSCFTNKYAEGLPG--NRYYGGNEVVDKIENLCQKRALEA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 106 FECNH----ADPRLLGGLHANTVVY-AVLKNHfnvSDISTLNTFYGGN-SSNHSLGPPGILNYSI--SDLP--VDPNTLe 175
Cdd:PTZ00094 93 FGLDPeewgVNVQPYSGSPANFAVYtALLQPH---DRIMGLDLPSGGHlTHGFYTAKKKVSATSIyfESLPyqVNEKGL- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 176 IDLNAFEYMAKFRQPKLVSLGSglNLFP--FPVKEIKDIISRWGGMLLFDGSHQAGLIAGGVYPNPLsLGADIYTASTGK 253
Cdd:PTZ00094 169 IDYDKLEELAKAFRPKLIIAGA--SAYPrdIDYKRFREICDSVGAYLMADIAHTSGLVAAGVLPSPF-PYADVVTTTTHK 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 254 TFSGPQGGVICWNSEK---FSSPISTTIFPKLTGSHQLNRIAALtvsCLELKEYG----LEYMAQGILNARQLASNLQAH 326
Cdd:PTZ00094 246 SLRGPRSGLIFYRKKVkpdIENKINEAVFPGLQGGPHNHQIAAI---AVQLKEVQspewKEYAKQVLKNAKALAAALEKR 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 327 GLEVLcsdEGFTETHQVVVKwTREEG-----ARLACyRLADVGVFANAVplPEDRELL--SGIRFGATEITRLGITQSQI 399
Cdd:PTZ00094 323 GYDLV---TGGTDNHLVLVD-LRPFGitgskMEKLL-DAVNISVNKNTI--PGDKSALnpSGVRLGTPALTTRGAKEKDF 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1634387221 400 VVLAEVIAGV---------------------LQGNYNLKEARNVVSELASTF 430
Cdd:PTZ00094 396 KFVADFLDRAvklaqeiqkqvgkklvdfkkaLEKNPELQKLRQEVVEFASQF 447
|
|
| PLN03226 |
PLN03226 |
serine hydroxymethyltransferase; Provisional |
31-406 |
4.20e-22 |
|
serine hydroxymethyltransferase; Provisional
Pssm-ID: 215639 Cd Length: 475 Bit Score: 98.13 E-value: 4.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 31 KLRALIErHETVRVKTGINLVAAEGPMS---LQARGllSCdLGSRASGGSIGrnNRFFTGLDQADEIEALCIVLLKELFe 107
Cdd:PLN03226 21 EIADIIE-KEKRRQWKGLELIASENFTSravMEALG--SC-LTNKYSEGLPG--ARYYGGNEYIDQIETLCQKRALEAF- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 108 cnHADPRLLG-------GLHANTVVY-AVLKNHfnvSDISTLNTFYGGNSSnHSLGPPG--ILNYSI--SDLP--VDPNT 173
Cdd:PLN03226 94 --RLDPEKWGvnvqplsGSPANFAVYtALLQPH---DRIMGLDLPHGGHLS-HGYQTDGkkISATSIyfESMPyrLDEST 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 174 LEIDLNAFEYMAKFRQPKLVSLGSglNLFP--FPVKEIKDIISRWGGMLLFDGSHQAGLIAGGVYPNPLSLgADIYTAST 251
Cdd:PLN03226 168 GLIDYDKLEKKAMLFRPKLIIAGA--SAYPrdWDYARMRKIADKVGALLMCDMAHISGLVAAQEAASPFEY-CDVVTTTT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 252 GKTFSGPQGGVICW-----NSEK--------FSSPISTTIFPKLTGSHQLNRIAALTVScleLK-----EYgLEYMAQGI 313
Cdd:PLN03226 245 HKSLRGPRGGMIFFrkgpkPPKGqgegavydYEDKINFAVFPGLQGGPHNHTIAALAVA---LKqamtpEF-KAYQKQVK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 314 LNARQLASNLQAHGLEvLCSDeGfTETHQVVV--KWTREEGARL--ACyRLADVGVFANAVplPEDRELLS--GIRFGAT 387
Cdd:PLN03226 321 ANAAALANRLMSKGYK-LVTG-G-TDNHLVLWdlRPLGLTGSRVekVL-DLAHITLNKNAV--PGDSSALVpgGVRIGTP 394
|
410
....*....|....*....
gi 1634387221 388 EITRLGITQSQIVVLAEVI 406
Cdd:PLN03226 395 AMTSRGLVEKDFEKVAEFL 413
|
|
| PLN02271 |
PLN02271 |
serine hydroxymethyltransferase |
34-433 |
3.47e-14 |
|
serine hydroxymethyltransferase
Pssm-ID: 215153 Cd Length: 586 Bit Score: 74.46 E-value: 3.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 34 ALIERHETVRVKtGINLVAAEGPMSLQARGLLSCDLGSRASGGSIGrnNRFFTGLDQADEIEALCIvllKELFECNHADP 113
Cdd:PLN02271 138 ELMEKEKQRQFK-GIELIASENFVCRAVMEALGSHLTNKYSEGMPG--ARYYTGNQYIDQIERLCC---ERALAAFGLDS 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 114 RLLGglhANTVVYAVLKNHFNV--------SDISTLNTFYGGNSSNHSLGPPG--ILNYSI--SDLP--VDPNTLEIDLN 179
Cdd:PLN02271 212 EKWG---VNVQPYSCTSANFAVytglllpgDRIMGLDSPSGGHMSHGYYTPGGkkVSGASIffESLPykVNPQTGYIDYD 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 180 AFEYMAKFRQPKLVSLGSGLNLFPFPVKEIKDIISRWGGMLLFDGSHQAGLIAGGVYPNPLSLgADIYTASTGKTFSGPQ 259
Cdd:PLN02271 289 KLEEKALDFRPKILICGGSSYPREWDYARFRQIADKCGAVLMCDMAHISGLVAAKECVNPFDY-CDIVTSTTHKSLRGPR 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 260 GGVICW----NSEK---------------FSSPISTTIFPKLTGSHQLNRIAALTVScleLK-----EYGLeYMAQGILN 315
Cdd:PLN02271 368 GGIIFYrkgpKLRKqgmllshgddnshydFEEKINFAVFPSLQGGPHNNHIAALAIA---LKqvatpEYKA-YMQQVKKN 443
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 316 ARQLASNLQAHGLEVLcsdEGFTETHQVVvkWT-REEGARLACY----RLADVGVfaNAVPLPEDRELLS--GIRFGATE 388
Cdd:PLN02271 444 AQALASALLRRKCRLV---TGGTDNHLLL--WDlTTLGLTGKNYekvcEMCHITL--NKTAIFGDNGTISpgGVRIGTPA 516
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1634387221 389 ITRLGITQSQIVVLAE------VIAGV---------------LQGNYNLKEARNVVSELASTFS--GF 433
Cdd:PLN02271 517 MTSRGCLESDFETIADfllraaQIASAvqrehgklqkeflkgLQNNKDIVELRNRVEAFASQFAmpGF 584
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
116-264 |
2.78e-11 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 62.01 E-value: 2.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 116 LGGLHAN-TVVYAVLKNHFNVsdISTLNTFYGgnSSNHSLGPPGilnYSISDLPVDPNTL-EIDLNAFEYMAKFRQPKLV 193
Cdd:cd01494 24 PSGTGANeAALLALLGPGDEV--IVDANGHGS--RYWVAAELAG---AKPVPVPVDDAGYgGLDVAILEELKAKPNVALI 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1634387221 194 ------SLGSGLNlfpfPVKEIKDIISRWGGMLLFDGSHQAGLIAGGVYPNPLSlGADIYTASTGKTFSGPQGGVIC 264
Cdd:cd01494 97 vitpntTSGGVLV----PLKEIRKIAKEYGILLLVDAASAGGASPAPGVLIPEG-GADVVTFSLHKNLGGEGGGVVI 168
|
|
| PRK12893 |
PRK12893 |
Zn-dependent hydrolase; |
312-393 |
2.82e-03 |
|
Zn-dependent hydrolase;
Pssm-ID: 237250 [Multi-domain] Cd Length: 412 Bit Score: 39.86 E-value: 2.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 312 GILNARQLASNLQAHGLEvlcsdegfTETHQVVVKWTREEGARLACYRLADvGVFANAVPLPEDRELLS--GIRFGAtEI 389
Cdd:PRK12893 99 GVLAALEVVRTLNDAGIR--------TRRPIEVVSWTNEEGARFAPAMLGS-GVFTGALPLDDALARRDadGITLGE-AL 168
|
....
gi 1634387221 390 TRLG 393
Cdd:PRK12893 169 ARIG 172
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
170-337 |
5.81e-03 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 38.83 E-value: 5.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 170 DPNTLEIDLNAFEYmAKFRQPKLVSLGSGLNlfP----FPVKEIKDIISRW---GGMLLFDGSHQAGLIAG-GVYPNPLS 241
Cdd:pfam00155 118 DSNDFHLDFDALEA-ALKEKPKVVLHTSPHN--PtgtvATLEELEKLLDLAkehNILLLVDEAYAGFVFGSpDAVATRAL 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1634387221 242 LGADIYTA---STGKTFS--GPQGGVICWNSE------KFSSPIsttifpklTGSHQLNRIAALTVSCLELKEYGLEYMA 310
Cdd:pfam00155 195 LAEGPNLLvvgSFSKAFGlaGWRVGYILGNAAvisqlrKLARPF--------YSSTHLQAAAAAALSDPLLVASELEEMR 266
|
170 180
....*....|....*....|....*...
gi 1634387221 311 QGIL-NARQLASNLQAHGLEVLCSDEGF 337
Cdd:pfam00155 267 QRIKeRRDYLRDGLQAAGLSVLPSQAGF 294
|
|
| |
