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Conserved domains on  [gi|1668483944|ref|WP_138204591|]
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MFS transporter [Haloimpatiens lingqiaonensis]

Protein Classification

MFS transporter( domain architecture ID 11454559)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020|GO:0015293|GO:0008643
PubMed:  26098515|23403214|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
91-386 6.99e-18

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


:

Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 85.34  E-value: 6.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  91 LLSRIIIFCFAFVPFFPDKYRPNIFIILFTLMSLPESLSVMSLQSFSGDIFPE-ENRSTAISMRNKFSTLFNVISLFILG 169
Cdd:COG2211    89 IPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPP 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 170 EIFNIVAHNNDQAILLYQILFVLSFIVGIIeiSTFMKLKEVNTIQMKEESFRDlkiQIPKILKNKKFSGFLICSLIFHFG 249
Cdd:COG2211   169 PLVAAFGGDAALGYRLTALIFAVLGLLAFL--LTFFGTKERPVPEEEKVSLKE---SLKALLKNRPFLLLLLAYLLFFLA 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 250 WQMGWPLFSIYQIKYLHANELWLTIINVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFYALSY--NLYVLT 327
Cdd:COG2211   244 LALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLL 323

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1668483944 328 LTGLITGFFTSGTLTVILSSLLEVCPEENRL-------LYVGLHATFTNLTLSIAPMVGNFVLSHT 386
Cdd:COG2211   324 VLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGALAGLLLALF 389
 
Name Accession Description Interval E-value
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
91-386 6.99e-18

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 85.34  E-value: 6.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  91 LLSRIIIFCFAFVPFFPDKYRPNIFIILFTLMSLPESLSVMSLQSFSGDIFPE-ENRSTAISMRNKFSTLFNVISLFILG 169
Cdd:COG2211    89 IPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPP 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 170 EIFNIVAHNNDQAILLYQILFVLSFIVGIIeiSTFMKLKEVNTIQMKEESFRDlkiQIPKILKNKKFSGFLICSLIFHFG 249
Cdd:COG2211   169 PLVAAFGGDAALGYRLTALIFAVLGLLAFL--LTFFGTKERPVPEEEKVSLKE---SLKALLKNRPFLLLLLAYLLFFLA 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 250 WQMGWPLFSIYQIKYLHANELWLTIINVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFYALSY--NLYVLT 327
Cdd:COG2211   244 LALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLL 323

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1668483944 328 LTGLITGFFTSGTLTVILSSLLEVCPEENRL-------LYVGLHATFTNLTLSIAPMVGNFVLSHT 386
Cdd:COG2211   324 VLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGALAGLLLALF 389
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 43-410 1.87e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 80.31  E-value: 1.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  43 FITRLGGGSFHLSLYNALPGLVGAFFMFPGIILiSKTKNKKKTMSKFFLLSRIIIFCFAFVPFFPdkyrpnIFIILFTLM 122
Cdd:cd17325    22 YAESLGASVAQIGLIVAAYALAQLLFSPPAGRL-SDRFGRKRLLLLGLLLLAVSTLLFAFATSYW------QLLLARFLQ 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 123 SLPESLSVMSLQSFSGDIFPEENRSTAISMRNKFSTLFNVISLFILGEIFNIVAHNndQAILLYQILFVLSFIVGIieis 202
Cdd:cd17325    95 GLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYR--APFLVCAALALLALVLAL---- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 203 tFMKLKEVNTIQMKEESFRDLKIQIPKILKNKKFSGFLICSLIFHFGWQMGWPLFSIYQIKYLHANELWLTIINVSSNVV 282
Cdd:cd17325   169 -LLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLA 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 283 MFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFYALSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRLLYVG 362
Cdd:cd17325   248 SALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMG 327

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1668483944 363 LHATFTNLTLSIAPMVGNFVLSHTNIYIALCISGLFRLIGSIAFYIRK 410
Cdd:cd17325   328 LFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_1 pfam07690
Major Facilitator Superfamily;
239-412 1.96e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 61.67  E-value: 1.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 239 FLICSLIFHFGWQMGWPLFSIYQIKYLHANELWLTIINVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFYA 318
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 319 LSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIYIALCISGLF 398
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170
                  ....*....|....
gi 1668483944 399 RLIGSIAFYIRKKH 412
Cdd:pfam07690 161 SLLAAVLLLLPRPP 174
 
Name Accession Description Interval E-value
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
91-386 6.99e-18

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 85.34  E-value: 6.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  91 LLSRIIIFCFAFVPFFPDKYRPNIFIILFTLMSLPESLSVMSLQSFSGDIFPE-ENRSTAISMRNKFSTLFNVISLFILG 169
Cdd:COG2211    89 IPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPP 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 170 EIFNIVAHNNDQAILLYQILFVLSFIVGIIeiSTFMKLKEVNTIQMKEESFRDlkiQIPKILKNKKFSGFLICSLIFHFG 249
Cdd:COG2211   169 PLVAAFGGDAALGYRLTALIFAVLGLLAFL--LTFFGTKERPVPEEEKVSLKE---SLKALLKNRPFLLLLLAYLLFFLA 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 250 WQMGWPLFSIYQIKYLHANELWLTIINVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFYALSY--NLYVLT 327
Cdd:COG2211   244 LALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLL 323

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1668483944 328 LTGLITGFFTSGTLTVILSSLLEVCPEENRL-------LYVGLHATFTNLTLSIAPMVGNFVLSHT 386
Cdd:COG2211   324 VLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGALAGLLLALF 389
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 43-410 1.87e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 80.31  E-value: 1.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  43 FITRLGGGSFHLSLYNALPGLVGAFFMFPGIILiSKTKNKKKTMSKFFLLSRIIIFCFAFVPFFPdkyrpnIFIILFTLM 122
Cdd:cd17325    22 YAESLGASVAQIGLIVAAYALAQLLFSPPAGRL-SDRFGRKRLLLLGLLLLAVSTLLFAFATSYW------QLLLARFLQ 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 123 SLPESLSVMSLQSFSGDIFPEENRSTAISMRNKFSTLFNVISLFILGEIFNIVAHNndQAILLYQILFVLSFIVGIieis 202
Cdd:cd17325    95 GLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYR--APFLVCAALALLALVLAL---- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 203 tFMKLKEVNTIQMKEESFRDLKIQIPKILKNKKFSGFLICSLIFHFGWQMGWPLFSIYQIKYLHANELWLTIINVSSNVV 282
Cdd:cd17325   169 -LLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLA 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 283 MFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFYALSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRLLYVG 362
Cdd:cd17325   248 SALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMG 327

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1668483944 363 LHATFTNLTLSIAPMVGNFVLSHTNIYIALCISGLFRLIGSIAFYIRK 410
Cdd:cd17325   328 LFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 21-408 6.60e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 75.93  E-value: 6.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  21 YYILNGILFTIMTALYKSFadkfITRLGGGSFHLSLYNALPGLVGAFFMFPGIILISKTkNKKKTMSKFFLLSRIIIFCF 100
Cdd:cd06174     4 GFFLTGLARGLISPLLPAL----LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALGALLF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 101 AFVPFFPdkyrpnIFIILFTLMSLPESLSVMSLQSFSGDIFPEENRSTAISMRNKFSTLFNVISLFILGEIFNIVAHNND 180
Cdd:cd06174    79 AFAPSFW------LLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWR 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 181 QAILLYQILFVLSFIVGIIEISTfmkLKEVNTIQMKEESFRDLKIQIPKILKNKKFSGFLICSLIFHFGWQMGWPLFSIY 260
Cdd:cd06174   153 AVFLIAAALALLAAILLLLVVPD---PPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLF 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 261 QIKYLHANELWLTIINVSSNVVMFFCYSYWNKLIQKK-GNAFVIMFATFGMAITPIFYALSYNLYVLTLTGLITGFFTSG 339
Cdd:cd06174   230 LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGG 309

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1668483944 340 TLTVILSSLLEVCPEENRLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIYIALCISGLFRLIGSIAFYI 408
Cdd:cd06174   310 LLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
23-375 3.65e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 70.00  E-value: 3.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  23 ILNGILFTIMTALYKSFADKFITRLGGGSFHLSLYNALPGLVGAFFMFPGIILISKtKNKKKTMSKFFLLSRIIIFCFAF 102
Cdd:COG2814    16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR-FGRRRVLLLGLLLFALGSLLCAL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 103 VPFFPdkyrpnIFIILFTLMSLPESLSVMSLQSFSGDIFPEENRSTAISMRNKFSTLFNVISLFILGEIFNIVAhnndqa 182
Cdd:COG2814    95 APSLW------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG------ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 183 illYQILFVLSFIVGIIE-ISTFMKLKEVntiqmKEESFRDLKIQIPKILKNKKFSGFLICSLIFHFGWQMGWPLFSIYQ 261
Cdd:COG2814   163 ---WRWVFLVNAVLALLAlLLLLRLLPES-----RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 262 IKYLHANELWLTIINVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFYALSYNLYVLTLTGLITGFFTSGTL 341
Cdd:COG2814   235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF 314

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1668483944 342 TVILSSLLEVCPEENRLLYVGLHATFTNLTLSIA 375
Cdd:COG2814   315 PLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 43-409 1.01e-11

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 66.10  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  43 FITRLGGGSFHLSLYNALPGLVGAFFMFPGIILISKTkNKKKTMSKFFLLSRIIIFCFAFVPFFPDKYRPNIFIILFtLM 122
Cdd:cd06173    25 LVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRF-DRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAF-LL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 123 SLPESLSVMSLQSFSGDIFPEENRSTAISMrnkFSTLFNVISLF--ILGEIfnIVAHNNDQAILlyqILFVLSFIVGIIE 200
Cdd:cd06173   103 GIASAFFGPARQALLPELVPKEQLVRANAL---NSLATQLARIIgpALGGL--LVALLGPGGAF---AINALSFLLSALL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 201 ISTFMKLKEVNTIQMKEESFRDLKIQIPKILKNKKFSGFLICSLIFHFGWQMGWPLFSIYQIKYLHANELWLTIINVSSN 280
Cdd:cd06173   175 LLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFG 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 281 V----VMFFCysywNKLIQKKGNAFVIMFATFGMAITPIFYALSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEEN 356
Cdd:cd06173   255 VgallGALLL----GRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDEL 330

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1668483944 357 RLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIYIALCISGLFRLIGSIAFYIR 409
Cdd:cd06173   331 RGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_1 pfam07690
Major Facilitator Superfamily;
239-412 1.96e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 61.67  E-value: 1.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 239 FLICSLIFHFGWQMGWPLFSIYQIKYLHANELWLTIINVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFYA 318
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 319 LSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIYIALCISGLF 398
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170
                  ....*....|....
gi 1668483944 399 RLIGSIAFYIRKKH 412
Cdd:pfam07690 161 SLLAAVLLLLPRPP 174
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
236-409 1.80e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 55.75  E-value: 1.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 236 FSGFLICSLIFHFGWQMGWPLFSIYQiKYLHANELWLTIINVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAITPI 315
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLIA-ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 316 FYALSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIYIALCIS 395
Cdd:COG2814    91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170

                         170
                  ....*....|....
gi 1668483944 396 GLFRLIGSIAFYIR 409
Cdd:COG2814   171 AVLALLALLLLLRL 184
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 239-411 3.90e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 54.89  E-value: 3.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 239 FLICSLIFHFGWQMGWPLFSIYqIKYLHANELWLTIINVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFYA 318
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLY-AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 319 LSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIYIALCISGLF 398
Cdd:cd17325    80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159

                         170
                  ....*....|...
gi 1668483944 399 RLIGSIAFYIRKK 411
Cdd:cd17325   160 ALLALVLALLLLP 172
MFS_1 pfam07690
Major Facilitator Superfamily;
22-376 2.10e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.42  E-value: 2.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  22 YILNGILFTIMTALYKSFADKFITRLGGGSFHLSLYNALPGLVGAFFMFPGIILISKTkNKKKTMSKFFLLSRIIIFCFA 101
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-GRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 102 FVPFFPdkyrpnIFIILFTLMSLPESLSVMSLQSFSGDIFPEENRSTAISMRNKFSTLFNVISLFILGEIFnivahnndq 181
Cdd:pfam07690  81 FASSLW------LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA--------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 182 AILLYQILFVLSFIVGIIEISTFMKLKEVNTIQMKEESFRDLKIQIP--KILKNKKFSGFLICSLIFHFGWQMGWPLFSI 259
Cdd:pfam07690 146 SLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVawKALLRDPVLWLLLALLLFGFAFFGLLTYLPL 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 260 YQiKYLHANELWLTIINVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFYAL---SYNLYVLTLTGLITGFF 336
Cdd:pfam07690 226 YQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLlslTLSSLWLLLALLLLGFG 304

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1668483944 337 TSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLTLSIAP 376
Cdd:pfam07690 305 FGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 243-412 8.38e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 50.67  E-value: 8.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 243 SLIFHFGWQMGWPLFSIYqIKYLHANELWLTIINVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFYALSYN 322
Cdd:cd17489     5 NFFFFLSFYLLLPVLPLY-AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 323 LYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIYIALCISGLFRLIG 402
Cdd:cd17489    84 VALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLA 163

                         170
                  ....*....|
gi 1668483944 403 SIAFYIRKKH 412
Cdd:cd17489   164 LLLVFLVKDP 173
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 61-349 1.60e-05

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 46.83  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  61 PGLVGAFFMFPGII----------LISKTKNKKKTMSKFFLLSRII--IFCFA--FVPFFPDKYRPNIFIILFTLMSLPE 126
Cdd:cd17332    34 AAAAGTIFLVARIIdaindplmgyLIDRTRSRWGRFRPWLLWGAIPlaLLFVLlfTTPDGSGTGKLIYALITYILLDLLY 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 127 SLSVMSLQSFSGDIFPEEN-RSTAISMRNKFSTLFNVISLFILGEIFNIVAHNNDQaiLLYQILFVLSFIVGIIEI-STF 204
Cdd:cd17332   114 TLVNIPYTALIPELTDDPEeRTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNAS--RGYFLTALIIGIIGIILLlICF 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 205 MKLKEVNTIQMKEESFRDLKIQIPKILKNKKFSGFLICSLIFHFGWQMGWPLFsIYQIKYLHANELWLTIINVSSNVVMF 284
Cdd:cd17332   192 FGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVL-VYYFKYVLGGRAELVLLLLLILSGAL 270

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1668483944 285 FCYSYWNKLIQKKG-NAFVIMFATFGMAITPIFYALSYNLYVLTLTGLITGFFTSGTLTVILSSLL 349
Cdd:cd17332   271 LALLPWPPLKKRFGkKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAML 336
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 34-383 2.43e-05

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 46.08  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  34 ALYKSFADKFITRLGGGSFHLSLYNALPGLVGaFFMFPGIILISKTKNKK--KTMSKFFLLSRIIIFCFAFVPF------ 105
Cdd:cd17313    16 ALENSYVPPILQTLGLSHALIGFVWTLGPILG-LFVQPLVGSLSDRCNSRigRRRPFILVGAPLAALGLILIPNaadigl 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 106 --FPDKYRPNI--FIILFTLMSLPESLSVMSLQSFSGDIFPEENRSTAISMRNKFSTLFNVISLFI------LGEIFNIV 175
Cdd:cd17313    95 alGDGPRTWALvlFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLgailwdHNWFGFAL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 176 AHNNDQAILLYQILFVLSFIVGIIEIS--TFMKLKEVNTIQMKEESFRDLKIQIpkiLKNKKFSGFLICSLIF--HFGWQ 251
Cdd:cd17313   175 GGNLKVPFYIGAIILLVCVLVTLFFVKepPLSPEAGEHSENPSLGEVLKSLLKL---LKIMPRSLLRLLLVIFfwWIAFF 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 252 MGWPLFSIY--QIKYLHANELWLTI---INVSSNVVMFFC-----YSY-WNKLIQKKGNAFVIMFATFGMAITPIFYALS 320
Cdd:cd17313   252 PFELFFTDYmgEEVYHGTSAASSHYgagVRMGAWGLLIFSlafliFSLpIGKLGKKIGRKKVYLIGLVLFAVGMALMALV 331

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1668483944 321 YNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRllYVGLHATFTNLTLSIAPMVGNFVL 383
Cdd:cd17313   332 HNVTVALVLFALGGIGWATININPYPLVSDYHSESGR--GQGTDTGLLNLAISLAQILVSLLA 392
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 54-406 2.57e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 46.00  E-value: 2.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  54 LSLYnALPGLVGAFFMFPgiilISKTKNKKKTMSKFFLLSRIIIFCFAFVPFFPdkyrpnIFIILFTLMSLPESLSVMSL 133
Cdd:cd17324    40 VSAY-ALGYALGALLLGP----LSDRIERRRLLLVLLLLFILGNLLAALAPSFA------LLLLARALAGLAHGGFWAIA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 134 QSFSGDIFPEENRSTAISMRNKFSTLFNVISLFI---LGEIFNivahnndqaillYQILFVLSFIVGIIEISTFMKLkeV 210
Cdd:cd17324   109 AAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLgglLGQLLG------------WRAAFLAIAVLALLAALLLWRL--L 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 211 NTIQMKEESFRDLKIQIPKILKNKK-FSGFLICSLIFhFGWQMGWPLFSIYQIKYLHANELWLTIINVSSNVVMFFCYSY 289
Cdd:cd17324   175 PSLPPKKPGSLGLLSSLLLLLRNPRlRLAYLITFLLF-GGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPL 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 290 WNKLIQKKGNAFVIMFATFGMAITPIFYALSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPeENRLLYVGLHATFTN 369
Cdd:cd17324   254 AGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYN 332

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1668483944 370 LTLSIAPMVGNFVLSHTNIYIALCISGLFRLIGSIAF 406
Cdd:cd17324   333 LGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
22-406 2.73e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 46.02  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  22 YILNGILFTIMTALYKSFADKFitrlGGGSFHLSLYNALPGLVGAFFMFPGIILISKtKNKKKTMSKFFLLSRIIIFCFA 101
Cdd:COG2271    19 YFLNYLDRSNLSVAAPPLQADL----GLSAAQLGLLASAFFLGYALGQIPAGLLADR-FGRRRVLAIGLLLWGLATLLFG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 102 FVPFFPdkyrpnIFIILFTLMSLPESLSVMSLQSFSGDIFPEENRSTAISMRNKFSTLFNVISLFILGEIFNIVAhnndq 181
Cdd:COG2271    94 FATSFW------QLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG----- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 182 aillYQILFVLSFIVGIIEIstfmklkevntiqmkeesfrdlkiqipkilknkkFSGFLICSLIFhFGWQMGWPLFSIYQ 261
Cdd:COG2271   163 ----WRAAFLILGLPGLLLA----------------------------------LLRFWLLALAY-FLVYFALYGFLTWL 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 262 IKYLHANE--------LWLTIINVSSNVVMFFCySYWNKLIQKKGnAFVIMFATFGMAITPIFYALSYNLYVLTLTGLIT 333
Cdd:COG2271   204 PTYLVEVRglslaqagLLLSLPFLAGIVGSLLG-GWLSDRLGRRR-KLVLAIGLLLAALALLLLALLPSPALAIALLFLA 281

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1668483944 334 GFFTSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIYIALCISGLFRLIGSIAF 406
Cdd:COG2271   282 GFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 292-409 1.10e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 44.10  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 292 KLIQKKGNAFVIMFATFGMAITPIFYALSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLT 371
Cdd:cd17473   255 RLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLG 334

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1668483944 372 LSIAPMVGNFVLSHT-NIYIALCISGLFRLIGSIAFYIR 409
Cdd:cd17473   335 QFLSPLVLGPLVNLTgGLSGAFLILGVLALVLAIVLLLL 373
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
239-408 1.55e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.72  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 239 FLICSLIFHFGWqMGWPLFSIYQIKY-----LHANEL-WLTIINVSSNVVMFFCYSYWnklIQKKGNAFVIMFATFGMAI 312
Cdd:COG2223     7 LLLATLAFFLAF-GVWYLWSVLAPPLaeefgLSAAQLgLLFAIPVLVGALLRIPLGFL---VDRFGPRRVLLIGLLLLGI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 313 TPIFYALSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIYIAL 392
Cdd:COG2223    83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162

                         170
                  ....*....|....*.
gi 1668483944 393 CISGLFRLIGSIAFYI 408
Cdd:COG2223   163 LILGILLLVVAVLAWL 178
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 292-412 2.93e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.55  E-value: 2.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 292 KLIQKKGNAFVIMFATFGMAITPIFYALSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLT 371
Cdd:cd17477    53 RLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLG 132

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1668483944 372 LSIAPMVGNFVLshTNIYIALCISGLFRLIGSIAFYIRKKH 412
Cdd:cd17477   133 FALGPLLLALVG--TAGALPFLIAAVLLLLALVPLLLTRRA 171
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 112-409 6.77e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.44  E-value: 6.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 112 PNIFIILFTLMSLPESLSVMSLQSFSGDIFPEENRSTAISMrnkFSTLFNV-------ISLFILGEIFNivahnndqaiL 184
Cdd:cd17329    88 PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSL---LYWAINLgvaigplLGGLLLLYSFR----------L 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 185 LYQILFVLSFIVGIIEISTFMKLKEVNTIQMKEESFRDLKIqipkILKNKKFSGFLICSLIFHFGWQMGWPLFSIYqIKY 264
Cdd:cd17329   155 LFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKI----VLRDRAFLLFLLASFLISLIYFQLESTLPVY-VVE 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 265 LHANELWLTIINVSSNVVMFFCYSYW-NKLIQKKGNAFVIMFATFGMAITPIFYALSYNLYVLTLTGLItgfFTSGTLTV 343
Cdd:cd17329   230 ILGLGESLLGLLLALNALLIVLLQFPvARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIV---LTLGEMLV 306

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1668483944 344 ILSSLLEV---CPEENRLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIYIALCISGLFRLIGSIAFYIR 409
Cdd:cd17329   307 FPAVQTLVaalAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 240-413 1.25e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 40.67  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 240 LICSLIFHFGWQMGWPLFSIYQIKYLHANELWLTIINVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFYAL 319
Cdd:cd17329     5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 320 SYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIYIALCISGLFR 399
Cdd:cd17329    85 AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFL 164

                         170
                  ....*....|....
gi 1668483944 400 LIGSIAFYIRKKHM 413
Cdd:cd17329   165 LAALVLLFLLPETR 178
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 269-412 1.67e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.33  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 269 ELWLTIINVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFYALSYNLYVL----TLTGLITGfFTSGTLTVI 344
Cdd:cd17391    35 ELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLlilrLLQGVFSG-YVPNATALI 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 345 LSSLlevcPEENRLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIYIALCISGLFRLIGSIA--FYIRKKH 412
Cdd:cd17391   114 ASQT----PKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLtlFFVKEDF 179
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 63-409 2.26e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.86  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  63 LVGAFFMFPGIILISKtKNKKKTMskffLLSRIIIFCFAFVPFFPDKYrpnIFIILFTLM-----SLPESLSVMSLqsfs 137
Cdd:cd17474    45 LPAAVLMPVAGVLADR-FGRKKVL----LPGLLLFGIGGLLCGLSDSF---ALLLAGRALqgigaAGLGPLALTLI---- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 138 GDIFPEENRSTAISMRNKFSTLFNVISLFILGEIFNIVahnndqaillYQILFVLSFIVGIIEISTFMKLKEVNTIQMKE 217
Cdd:cd17474   113 GDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS----------WRYPFFLLAALIPVAFLAILFLLPEPKEKAKS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 218 ESFRDLKIQIpKILKNKKFSGFLICSLIFHFGWQMGWPLFSIYQIKYLHANELWLTIInVSSNVVMFFCYSYWNKLIQKK 297
Cdd:cd17474   183 SSATKLRDLK-KALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLL-FAGWSVLLALGSLFVGRLLKK 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 298 --GNAFVIMFATFGMAITPIFYALSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLTLSIA 375
Cdd:cd17474   261 rfGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1668483944 376 PMVGNFVLSHTNIYIALCISGLFRLIGSIAFYIR 409
Cdd:cd17474   341 PLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 302-408 2.84e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 39.48  E-value: 2.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 302 VIMFATFGMAITPIFYALSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLTLSIAPMVGNF 381
Cdd:cd17323    66 VYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGF 145

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1668483944 382 VLSHTN----IYIALCISGLFRLIGSIAFYI 408
Cdd:cd17323   146 ITQSLGwrwiFWFLAIISGFCLILIFLFLPI 176
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 240-405 3.14e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.48  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 240 LICSLIFHFGWQMGWPL--FSIYQIKYLHANELWLTIINVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAITPIFY 317
Cdd:cd17330     2 FLVVFLDALGFGIVFPVlpFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 318 ALSYNLYVLTLTGLITGFFtSGTLTVILSSLLEVCPEENRLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIYIALCISGL 397
Cdd:cd17330    82 GLSRNLWLLFLARFLDGLT-GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160


                  ....*...
gi 1668483944 398 FRLIGSIA 405
Cdd:cd17330   161 LALLNLVL 168
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
21-164 5.45e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.80  E-value: 5.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  21 YYILNGILFTIMTALYKSFADKFITRLGGGSFHLSLYNALPGLVGAFFMFPGIILISKTkNKKKTMSKFFLLSRIIIFCF 100
Cdd:COG2814   212 LLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-GRRRLLLIGLLLLALGLLLL 290

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1668483944 101 AFVPFFPdkyrpnIFIILFTLMSLPESLSVMSLQSFSGDIFPEENRSTAISMrnkFSTLFNVIS 164
Cdd:COG2814   291 ALAGSLW------LLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL---YNSAFFLGG 345
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
39-419 6.40e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 38.71  E-value: 6.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944  39 FADKFITRLGGGSFHLSLYNALPGLVGAFFMFPGIILISKTKNKKKTMSKFFLLSrIIIFCFAFVPFFPdkyrpnIFIIL 118
Cdd:COG2223    27 LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG-IGLLLLALAVSYW------LLLLL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 119 FTLMSLPESLSVMSLQSFSGDIFPEENRSTAISMrnkFSTLFN---VISLFILGEIFNIVAHNNdqAILLYQILFVLSFI 195
Cdd:COG2223   100 GLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGL---AAGGGNlgaAVAAFLAPLLIAAFGWRN--AFLILGILLLVVAV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 196 VgiieISTFMKLKEVNTIQMKEESFRDLKiqipKILKNKKFSGFLICSLIFHFGWQMGWPLFSIYQIKYLHANELWLTII 275
Cdd:COG2223   175 L----AWLFLRDPPAGAAAAAKASLRDQL----EALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1668483944 276 NVSSNVVMFFCYSYWNKLIQKKGNAFVIMFATFGMAI-TPIFYALSYNLYVLTLTGLITGFFTSGTLTVILSSLLEVCPE 354
Cdd:COG2223   247 AALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALgLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPT 326

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1668483944 355 ENRLLYVGLHATFTNLTLSIAPMVGNFVLSHTNIY-IALCISGLFRLIGSIAFYIRKKHMENIVNS 419
Cdd:COG2223   327 KNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYtAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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