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Conserved domains on  [gi|1672722469|ref|WP_138362547|]
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MULTISPECIES: citrate lyase acyl carrier protein [Klebsiella]

Protein Classification

citrate lyase acyl carrier protein( domain architecture ID 10014154)

citrate lyase acyl carrier protein CitD, together with CitE and CitF, catalyzes the formation of oxaloacetate from citrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13253 PRK13253
citrate lyase subunit gamma; Provisional
 1-91 4.28e-42

citrate lyase subunit gamma; Provisional


:

Pssm-ID: 237316  Cd Length: 92  Bit Score: 132.67  E-value: 4.28e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672722469  1 MKIVREALAGTLESSDLMVKIAPAE-GELDVVVRSEVIKQFGEQIRQVVNATLRAMDVHQGLIIIEDKGALDCVIRARLQ 79
Cdd:PRK13253   1 MKIKKTAVAGTLESSDVMIRIAPADtQGIDIQLESSVEKQFGDQIRAVILETLAKLGVENAQVKVDDKGALDCVIRARLE 80

                         90
                 ....*....|..
gi 1672722469 80 SAILRASEATEI 91
Cdd:PRK13253  81 AAVLRAAGIEAL 92
 
Name Accession Description Interval E-value
PRK13253 PRK13253
citrate lyase subunit gamma; Provisional
 1-91 4.28e-42

citrate lyase subunit gamma; Provisional


Pssm-ID: 237316  Cd Length: 92  Bit Score: 132.67  E-value: 4.28e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672722469  1 MKIVREALAGTLESSDLMVKIAPAE-GELDVVVRSEVIKQFGEQIRQVVNATLRAMDVHQGLIIIEDKGALDCVIRARLQ 79
Cdd:PRK13253   1 MKIKKTAVAGTLESSDVMIRIAPADtQGIDIQLESSVEKQFGDQIRAVILETLAKLGVENAQVKVDDKGALDCVIRARLE 80

                         90
                 ....*....|..
gi 1672722469 80 SAILRASEATEI 91
Cdd:PRK13253  81 AAVLRAAGIEAL 92
CitD COG3052
Acyl-carrier protein (citrate lyase gamma subunit) [Energy production and conversion];
1-90 6.33e-41

Acyl-carrier protein (citrate lyase gamma subunit) [Energy production and conversion];


Pssm-ID: 442286  Cd Length: 91  Bit Score: 129.52  E-value: 6.33e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672722469  1 MKIVREALAGTLESSDLMVKIAPAE-GELDVVVRSEVIKQFGEQIRQVVNATLRAMDVHQGLIIIEDKGALDCVIRARLQ 79
Cdd:COG3052    1 MEIKKEAVAGTLESSDLMVTVEPADgGGIEIELTSSVEKQFGDQIRAVVRETLARLGVTGAKVIIEDKGALDCVIRARLE 80

                         90
                 ....*....|.
gi 1672722469 80 SAILRASEATE 90
Cdd:COG3052   81 TALERALGSEE 91
ACP pfam06857
Malonate decarboxylase delta subunit (MdcD); This family consists of several bacterial ...
 4-85 3.37e-31

Malonate decarboxylase delta subunit (MdcD); This family consists of several bacterial malonate decarboxylase delta subunit (MdcD) proteins. Malonate decarboxylase of Klebsiella pneumoniae consists of four different subunits and catalyzes the conversion of malonate plus H+ to acetate and CO2. The catalysis proceeds via acetyl and malonyl thioester residues with the phosphribosyl-dephospho-CoA prosthetic group of the acyl carrier protein (ACP) subunit. MdcC is the (apo) ACP subunit. The family also contains the CitD family of citrate lyase acyl carrier proteins.


Pssm-ID: 429157  Cd Length: 83  Bit Score: 104.89  E-value: 3.37e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672722469  4 VREALAGTLESSDLMVKIAPA-EGELDVVVRSEVIKQFGEQIRQVVNATLRAMDVHQGLIIIEDKGALDCVIRARLQSAI 82
Cdd:pfam06857  1 KKTALAGTLESSDLEVTVEPAlGGGIEIELESSVAKQFGDQIRAVIEETLEELGVKDAKVTINDKGALDCVIRARLEQAL 80


                 ...
gi 1672722469 83 LRA 85
Cdd:pfam06857 81 ERA 83
citD TIGR01608
citrate lyase acyl carrier protein; This is a model of the acyl carrier protein (aka gamma ...
 1-90 1.73e-23

citrate lyase acyl carrier protein; This is a model of the acyl carrier protein (aka gamma subunit) of the holoenzyme citrate lyase (EC 4.1.3.6) composed of alpha (EC 2.8.3.10), beta (EC 4.1.3.34), and acyl carrier protein subunits in a stoichiometric relationship of 6:6:6. Citrate lyase is an enzyme which converts citrate to oxaloacetate. In bacteria, this reaction is involved in citrate fermentation. The acyl carrier protein covalently binds the coenzyme of citrate lyase. The seed contains an experimentally characterized member from Leuconostoc mesenteroides. The model covers a wide range of Gram positive bacteria. For Gram negative bacteria, it appears that only gamma proteobacteria hit this model. The model is quite robust with queries scoring either quite well or quite poorly against the model. There are currently no hits in-between the noise cutoff and trusted cutoff. [Energy metabolism, Fermentation]


Pssm-ID: 130669  Cd Length: 92  Bit Score: 85.67  E-value: 1.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672722469  1 MKIVREALAGTLESSDLMVKIAPA-EGELDVVVRSEVIKQFGEQIRQVVNATLRAMDVHQGLIIIEDKGALDCVIRARLQ 79
Cdd:TIGR01608  1 MEIKKTALAGTLESSDVMIMVEPAmQVGIEIDLVSDVKKQFGDDIESTVKETLKLLGVENAVVKVVDKGALNCVIKARTL 80

                         90
                 ....*....|.
gi 1672722469 80 SAILRASEATE 90
Cdd:TIGR01608 81 AAVQRAAEAND 91
 
Name Accession Description Interval E-value
PRK13253 PRK13253
citrate lyase subunit gamma; Provisional
 1-91 4.28e-42

citrate lyase subunit gamma; Provisional


Pssm-ID: 237316  Cd Length: 92  Bit Score: 132.67  E-value: 4.28e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672722469  1 MKIVREALAGTLESSDLMVKIAPAE-GELDVVVRSEVIKQFGEQIRQVVNATLRAMDVHQGLIIIEDKGALDCVIRARLQ 79
Cdd:PRK13253   1 MKIKKTAVAGTLESSDVMIRIAPADtQGIDIQLESSVEKQFGDQIRAVILETLAKLGVENAQVKVDDKGALDCVIRARLE 80

                         90
                 ....*....|..
gi 1672722469 80 SAILRASEATEI 91
Cdd:PRK13253  81 AAVLRAAGIEAL 92
CitD COG3052
Acyl-carrier protein (citrate lyase gamma subunit) [Energy production and conversion];
1-90 6.33e-41

Acyl-carrier protein (citrate lyase gamma subunit) [Energy production and conversion];


Pssm-ID: 442286  Cd Length: 91  Bit Score: 129.52  E-value: 6.33e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672722469  1 MKIVREALAGTLESSDLMVKIAPAE-GELDVVVRSEVIKQFGEQIRQVVNATLRAMDVHQGLIIIEDKGALDCVIRARLQ 79
Cdd:COG3052    1 MEIKKEAVAGTLESSDLMVTVEPADgGGIEIELTSSVEKQFGDQIRAVVRETLARLGVTGAKVIIEDKGALDCVIRARLE 80

                         90
                 ....*....|.
gi 1672722469 80 SAILRASEATE 90
Cdd:COG3052   81 TALERALGSEE 91
ACP pfam06857
Malonate decarboxylase delta subunit (MdcD); This family consists of several bacterial ...
 4-85 3.37e-31

Malonate decarboxylase delta subunit (MdcD); This family consists of several bacterial malonate decarboxylase delta subunit (MdcD) proteins. Malonate decarboxylase of Klebsiella pneumoniae consists of four different subunits and catalyzes the conversion of malonate plus H+ to acetate and CO2. The catalysis proceeds via acetyl and malonyl thioester residues with the phosphribosyl-dephospho-CoA prosthetic group of the acyl carrier protein (ACP) subunit. MdcC is the (apo) ACP subunit. The family also contains the CitD family of citrate lyase acyl carrier proteins.


Pssm-ID: 429157  Cd Length: 83  Bit Score: 104.89  E-value: 3.37e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672722469  4 VREALAGTLESSDLMVKIAPA-EGELDVVVRSEVIKQFGEQIRQVVNATLRAMDVHQGLIIIEDKGALDCVIRARLQSAI 82
Cdd:pfam06857  1 KKTALAGTLESSDLEVTVEPAlGGGIEIELESSVAKQFGDQIRAVIEETLEELGVKDAKVTINDKGALDCVIRARLEQAL 80


                 ...
gi 1672722469 83 LRA 85
Cdd:pfam06857 81 ERA 83
citD TIGR01608
citrate lyase acyl carrier protein; This is a model of the acyl carrier protein (aka gamma ...
 1-90 1.73e-23

citrate lyase acyl carrier protein; This is a model of the acyl carrier protein (aka gamma subunit) of the holoenzyme citrate lyase (EC 4.1.3.6) composed of alpha (EC 2.8.3.10), beta (EC 4.1.3.34), and acyl carrier protein subunits in a stoichiometric relationship of 6:6:6. Citrate lyase is an enzyme which converts citrate to oxaloacetate. In bacteria, this reaction is involved in citrate fermentation. The acyl carrier protein covalently binds the coenzyme of citrate lyase. The seed contains an experimentally characterized member from Leuconostoc mesenteroides. The model covers a wide range of Gram positive bacteria. For Gram negative bacteria, it appears that only gamma proteobacteria hit this model. The model is quite robust with queries scoring either quite well or quite poorly against the model. There are currently no hits in-between the noise cutoff and trusted cutoff. [Energy metabolism, Fermentation]


Pssm-ID: 130669  Cd Length: 92  Bit Score: 85.67  E-value: 1.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1672722469  1 MKIVREALAGTLESSDLMVKIAPA-EGELDVVVRSEVIKQFGEQIRQVVNATLRAMDVHQGLIIIEDKGALDCVIRARLQ 79
Cdd:TIGR01608  1 MEIKKTALAGTLESSDVMIMVEPAmQVGIEIDLVSDVKKQFGDDIESTVKETLKLLGVENAVVKVVDKGALNCVIKARTL 80

                         90
                 ....*....|.
gi 1672722469 80 SAILRASEATE 90
Cdd:TIGR01608 81 AAVQRAAEAND 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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