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Conserved domains on  [gi|1675096099|ref|WP_138611163|]
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MULTISPECIES: universal stress protein UspE [Pseudoalteromonas]

Protein Classification

universal stress protein UspE( domain architecture ID 11485249)

universal stress protein UspE is a tandem-type universal stress protein (USP) that consists of two Usp domains and is required for resistance to DNA-damaging agents; enhances the rate of cell survival during prolonged exposure to stress agents

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11175 PRK11175
universal stress protein UspE; Provisional
 5-303 0e+00

universal stress protein UspE; Provisional


:

Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 525.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099   5 KRILAVIDPTKDDHHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSFEEREAMRKAVINDRELWLKDIISSY--PDV 82
Cdd:PRK11175    4 QNILVVIDPNQDDQPALRRAVYLAQRNGGKITAFLPIYDFSYEMTTLLSPDEREAMRQGVISQRTAWIREQAKPYldAGI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099  83 NITAQVVWHNRPFEAIINTVIEQEYDLVVKSTHQHGALKSVIFTPTDWHLVRKCPTPVLFVKEMAWPEQGNILAAVNAVS 162
Cdd:PRK11175   84 PIEIKVVWHNRPFEAIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQDWPEGGKILVAVNVAS 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099 163 ENDEHVALNKRIIKDAQFLCE-LANAKLNLVNAYPATPINIAIEIPEFNPGLYNESVKKHHIESTNELAKTFSLTNEQCF 241
Cdd:PRK11175  164 EEPYHDALNEKLVEEAIDLAEqLNHAEVHLVNAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGIDEEQTH 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1675096099 242 IEEGLPEDVIPDVANRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVLALKPDGYVS 303
Cdd:PRK11175  244 VEEGLPEEVIPDLAEHLDAELVILGTVGRTGLSAAFLGNTAEHVIDHLNCDLLAIKPDGYVS 305
 
Name Accession Description Interval E-value
PRK11175 PRK11175
universal stress protein UspE; Provisional
 5-303 0e+00

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 525.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099   5 KRILAVIDPTKDDHHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSFEEREAMRKAVINDRELWLKDIISSY--PDV 82
Cdd:PRK11175    4 QNILVVIDPNQDDQPALRRAVYLAQRNGGKITAFLPIYDFSYEMTTLLSPDEREAMRQGVISQRTAWIREQAKPYldAGI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099  83 NITAQVVWHNRPFEAIINTVIEQEYDLVVKSTHQHGALKSVIFTPTDWHLVRKCPTPVLFVKEMAWPEQGNILAAVNAVS 162
Cdd:PRK11175   84 PIEIKVVWHNRPFEAIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQDWPEGGKILVAVNVAS 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099 163 ENDEHVALNKRIIKDAQFLCE-LANAKLNLVNAYPATPINIAIEIPEFNPGLYNESVKKHHIESTNELAKTFSLTNEQCF 241
Cdd:PRK11175  164 EEPYHDALNEKLVEEAIDLAEqLNHAEVHLVNAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGIDEEQTH 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1675096099 242 IEEGLPEDVIPDVANRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVLALKPDGYVS 303
Cdd:PRK11175  244 VEEGLPEEVIPDLAEHLDAELVILGTVGRTGLSAAFLGNTAEHVIDHLNCDLLAIKPDGYVS 305
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 151-298 2.11e-59

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 186.71  E-value: 2.11e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099 151 QGNILAAVNAVSENDEHVALNKRIIKDAQFLCELANAKLNLVNAYPATPINIAIEIPEFNPGLYNESVKKHHIESTNELA 230
Cdd:cd23660     1 GGRILVAVDPSNEEEYHEDLNLRLIELAYSLAAQLKAELHLVSAWPVTPENIAIELPEFDPTEYVDAIRGRHLEAMKALR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1675096099 231 KTFSLTNEQCFIEEGLPEDVIPDVANRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVLALKP 298
Cdd:cd23660    81 QKFGIDEEQTHVLEGLPEEVIPDFAEELDADIVVLGTVARTGLSGALIGNTAEHVLDHLNCDLLALKP 148
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-143 2.35e-21

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 87.67  E-value: 2.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099   3 TIKRILAVIDPTKDDHHGLARSIDLAKKSGASITAFmTVYDFSYEMttmlsFEEREAMRKAVINDRELWLKDIISSYPDV 82
Cdd:COG0589     1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLL-HVVDPPPSA-----AAGPEELEEELREEAEEALEEAAERLEEA 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1675096099  83 NITAQ-VVWHNRPFEAIINTVIEQEYDLVVKSTHQHGALKSVIFTPTDWHLVRKCPTPVLFV 143
Cdd:COG0589    75 GVEVEtVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLVV 136
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 7-144 1.62e-17

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 77.45  E-value: 1.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099   7 ILAVIDPTKDDHHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSFEEREAMRKAVINDRELWLKDIISSYPDVNITA 86
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1675096099  87 QVVWHNrPFEAIINTVIEQEYDLVVKSTHQHGALKSVIFTPTDWHLVRKCPTPVLFVK 144
Cdd:pfam00582  81 VVVVGD-PAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
 
Name Accession Description Interval E-value
PRK11175 PRK11175
universal stress protein UspE; Provisional
 5-303 0e+00

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 525.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099   5 KRILAVIDPTKDDHHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSFEEREAMRKAVINDRELWLKDIISSY--PDV 82
Cdd:PRK11175    4 QNILVVIDPNQDDQPALRRAVYLAQRNGGKITAFLPIYDFSYEMTTLLSPDEREAMRQGVISQRTAWIREQAKPYldAGI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099  83 NITAQVVWHNRPFEAIINTVIEQEYDLVVKSTHQHGALKSVIFTPTDWHLVRKCPTPVLFVKEMAWPEQGNILAAVNAVS 162
Cdd:PRK11175   84 PIEIKVVWHNRPFEAIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQDWPEGGKILVAVNVAS 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099 163 ENDEHVALNKRIIKDAQFLCE-LANAKLNLVNAYPATPINIAIEIPEFNPGLYNESVKKHHIESTNELAKTFSLTNEQCF 241
Cdd:PRK11175  164 EEPYHDALNEKLVEEAIDLAEqLNHAEVHLVNAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGIDEEQTH 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1675096099 242 IEEGLPEDVIPDVANRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVLALKPDGYVS 303
Cdd:PRK11175  244 VEEGLPEEVIPDLAEHLDAELVILGTVGRTGLSAAFLGNTAEHVIDHLNCDLLAIKPDGYVS 305
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 151-298 2.11e-59

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 186.71  E-value: 2.11e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099 151 QGNILAAVNAVSENDEHVALNKRIIKDAQFLCELANAKLNLVNAYPATPINIAIEIPEFNPGLYNESVKKHHIESTNELA 230
Cdd:cd23660     1 GGRILVAVDPSNEEEYHEDLNLRLIELAYSLAAQLKAELHLVSAWPVTPENIAIELPEFDPTEYVDAIRGRHLEAMKALR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1675096099 231 KTFSLTNEQCFIEEGLPEDVIPDVANRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVLALKP 298
Cdd:cd23660    81 QKFGIDEEQTHVLEGLPEEVIPDFAEELDADIVVLGTVARTGLSGALIGNTAEHVLDHLNCDLLALKP 148
USP-E_repeat1 cd23943
Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP ...
 5-144 7.71e-57

Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467508  Cd Length: 143  Bit Score: 180.06  E-value: 7.71e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099   5 KRILAVIDPTKDDHHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSFEEREAMRKAVINDRELWLKDIISSY--PDV 82
Cdd:cd23943     2 QNMLVVIDPNQDDQPALRRAVYLVQRIGGKIKAFLPIYDLSYEMTTLLSPDERTAMRQGVISQRTAWIREQAKYYleAGI 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1675096099  83 NITAQVVWHNRPFEAIINTVIEQEYDLVVKSTHQHGALKSVIFTPTDWHLVRKCPTPVLFVK 144
Cdd:cd23943    82 PIEIKVVWHNRPFEAIIQEVIAGNHDLVLKMAHQHDRLESLIFTPTDWHLLRKCPSPVWMVK 143
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
3-143 2.35e-21

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 87.67  E-value: 2.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099   3 TIKRILAVIDPTKDDHHGLARSIDLAKKSGASITAFmTVYDFSYEMttmlsFEEREAMRKAVINDRELWLKDIISSYPDV 82
Cdd:COG0589     1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLL-HVVDPPPSA-----AAGPEELEEELREEAEEALEEAAERLEEA 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1675096099  83 NITAQ-VVWHNRPFEAIINTVIEQEYDLVVKSTHQHGALKSVIFTPTDWHLVRKCPTPVLFV 143
Cdd:COG0589    75 GVEVEtVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLVV 136
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 7-144 1.62e-17

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 77.45  E-value: 1.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099   7 ILAVIDPTKDDHHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSFEEREAMRKAVINDRELWLKDIISSYPDVNITA 86
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1675096099  87 QVVWHNrPFEAIINTVIEQEYDLVVKSTHQHGALKSVIFTPTDWHLVRKCPTPVLFVK 144
Cdd:pfam00582  81 VVVVGD-PAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 6-143 7.73e-17

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 75.46  E-value: 7.73e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099   6 RILAVIDPTKDDHHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSFEEREAMRKAVindRELwLKDIISSYPDVNIT 85
Cdd:cd00293     1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEELADELKEEA---EEL-LEEAKKLAEEAGVE 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1675096099  86 AQV-VWHNRPFEAIINTVIEQEYDLVVKSTHQHGALKSVIFTPTDWHLVRKCPTPVLFV 143
Cdd:cd00293    77 VETiVVEGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
153-294 2.85e-15

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 71.11  E-value: 2.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099 153 NILAAVNAvSENDEHValnkriIKDAQFLCELANAKLNLVNAYPATPIniaieiPEFNPGLYNESVKKHHIESTNELAKT 232
Cdd:COG0589     4 RILVPTDG-SEEAERA------LEYAAELAKALGAELHLLHVVDPPPS------AAAGPEELEEELREEAEEALEEAAER 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1675096099 233 FSLTN--EQCFIEEGLPEDVIPDVANRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVL 294
Cdd:COG0589    71 LEEAGveVETVVREGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVL 134
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 153-294 1.78e-11

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 60.82  E-value: 1.78e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099 153 NILAAVNAvSENdehvalNKRIIKDAQFLCELANAKLNLVNAYPATPINIAIEIPEFNPGLYNESVKKHhIESTNELAkT 232
Cdd:cd00293     1 KILVAVDG-SEE------SERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEELADELKEEAEEL-LEEAKKLA-E 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1675096099 233 FSLTNEQCFIEEGLPEDVIPDVANRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVL 294
Cdd:cd00293    72 EAGVEVETIVVEGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVL 133
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 154-297 4.74e-11

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 59.73  E-value: 4.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099 154 ILAAVNAvSENDEHVAlnKRIIKDAQflceLANAKLNLVNAYPATPINIAIEIPEFNPGLYNESVKKHHIESTNELAKTF 233
Cdd:pfam00582   1 ILVAVDG-SEESKRAL--EWAAELAK----ARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEA 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1675096099 234 SLTNEQCFIEEGLPEDVIPDVANRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVLALK 297
Cdd:pfam00582  74 GGVKVEVVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 153-298 1.64e-08

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 52.31  E-value: 1.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099 153 NILAAVnAVSENDehvalnKRIIKDAQFLCELANAKLNLvnaypatpINIAIEIPEFNPGLYNESVK-------KHHIES 225
Cdd:cd23657     3 HILVAV-DLSPES------QSLVDKAVEIARENDAKLSL--------IHVDEDISEYYTGLIDVDIAalqdlesTMLEEA 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1675096099 226 TNELAKTFSLTNEQCFIEEGLPEDVIPDVANRLNSELVVIGTVGRTGLSaaLVGNTAEHVIDSLDCDVLALKP 298
Cdd:cd23657    68 LKNLSELAGYPVDHTFIGYGDLKEEILEVAKKHNVDLIVCGHHGDFGLS--LLGSSARAVLNSAPCDVLIVPL 138
USP_Rv2623_repeat2 cd23661
universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis ...
 7-144 2.70e-04

universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition, Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467507 [Multi-domain]  Cd Length: 133  Bit Score: 40.19  E-value: 2.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099   7 ILAVIDPTKDDHHGLARSIDLAKKSGASITAFMTVYDFSYEMTTMLSFEEREAMRKAVINDRelwLKDIISSYPDVNITA 86
Cdd:cd23661     2 VVVGVDGSPASELATEIAFDEASRRGVDLVALHAWSDMGPGGFLGIDWRESEQDQERMLAER---LAGWQERYPDVHVHK 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1675096099  87 QVVwHNRPFEAIINTviEQEYDLVVKSTHQHGALKSVIFTPTDWHLVRKCPTPVLFVK 144
Cdd:cd23661    79 VVV-RDRPARVLLEA--SERAQLVVVGSHGRGGFAGMLLGSVSRAVLHSAPCPVIVVR 133
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 242-294 3.03e-04

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 40.30  E-value: 3.03e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1675096099 242 IEEGLPEDVIPDVANRLNSELVVIGTVGRTGLSAALVGNTAEHVIDSLDCDVL 294
Cdd:cd23659    88 VVAGDPGEVICKAAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVL 140
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 5-144 1.91e-03

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 37.99  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675096099   5 KRILAVIDPTKDDHHGLARSIDLAKKSGASITAFMTV--YDFSYEMTTMLSFEEREAMRKAVINDRELW--LKDIISSYP 80
Cdd:cd23659     1 RKVLIAVDGSEESEYALEWALENLHRPGDEVVLLHVIepPSLPAASLGSGSEEWEALEEEAREKAEKLLekYEKKLKEEK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1675096099  81 DVNITAQVVWHNrPFEAIINTVIEQEYDLVVKSTHQHGALKSVIFTPTDWHLVRKCPTPVLFVK 144
Cdd:cd23659    81 GIKVKVEVVAGD-PGEVICKAAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVLVVR 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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