|
Name |
Accession |
Description |
Interval |
E-value |
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
1-1023 |
0e+00 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 1236.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 1 MFSRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMS 80
Cdd:COG0841 2 NLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYIT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 81 STSTSAGSTtIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQKGSSSFLQVHAFYSPDGTRSSLwtSNYVT 160
Cdd:COG0841 82 STSSEGSSS-ITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKVNPSDFPVMVLALSSDDLDELEL--SDYAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 161 MNVLDRVKRIPGTTSVQIFGAKDYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIGAtpttqspQELVYSVTAQ 240
Cdd:COG0841 159 RNIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGG-------GDREYTVRTN 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 241 GRLSEPEQFENIIIRSNtDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQF 320
Cdd:COG0841 232 GRLKTPEEFENIVIRTN-DGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 321 PTGLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFG 400
Cdd:COG0841 311 PEGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFA 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 401 MVLSIGIVVDDAIVVLENVERIMhEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIA 480
Cdd:COG0841 391 LVLAIGIVVDDAIVVVENIERHM-EEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIA 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 481 VSLSGVVALTMTPALCVLILKQEHK-QTARFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIGLWQNTPG 559
Cdd:COG0841 470 LLISLFVALTLTPALCARLLKPHPKgKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPT 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 560 SLVPDEDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPANENVVAFTGFDFIGGGykNSAATLFVTQKHWDEREVDT 639
Cdd:COG0841 550 EFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSG--SNSGTIFVTLKPWDERDRSA 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 640 KALVQELFMKTAGIKEALVLAFNPPAIfGLGNTGGFEFYIQnkgDSDPDKLQHAMQLMTAEAQKSPIISGLQTLWRPDAP 719
Cdd:COG0841 628 DEIIARLREKLAKIPGARVFVFQPPAG-GLGSGAPIEVQLQ---GDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKP 703
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 720 QLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQGTMVPLSAFT 799
Cdd:COG0841 704 ELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVA 783
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 800 TIEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAQA-VLPPNMTYEWTGSAFQEKRSSGTTGIALGLAVIM 878
Cdd:COG0841 784 TIEEGTGPSSINRYNGQRSVTVSANLAPGVSLGEALAAIEELAAElKLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLL 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 879 VFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYALMKHQQGWSASTAA 958
Cdd:COG0841 864 VYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLREEGMSLREAI 943
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1675103803 959 LEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVPLFFYWL 1023
Cdd:COG0841 944 LEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLL 1008
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
2-1041 |
0e+00 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 1183.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 2 FSRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSS 81
Cdd:TIGR00915 1 MAKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 82 TSTSAGSTTIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQKGSSSFLQVHAFYSPDGTRSSLWTSNYVTM 161
Cdd:TIGR00915 81 SSDSDGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGVRVEKASSNFLMVIGLVSDDGSMTKEDLSDYAAS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 162 NVLDRVKRIPGTTSVQIFGAKdYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIGATPTTQSpQELVYSVTAQG 241
Cdd:TIGR00915 161 NMVDPLSRLEGVGDVQLFGSQ-YAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLGGLPAVPG-QQLNATIIAQT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 242 RLSEPEQFENIIIRSNTDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFP 321
Cdd:TIGR00915 239 RLQTPEQFENILLKVNTDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 322 TGLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGM 401
Cdd:TIGR00915 319 QGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAM 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 402 VLSIGIVVDDAIVVLENVERIMHEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAV 481
Cdd:TIGR00915 399 VLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAM 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 482 SLSGVVALTMTPALCVLILK-----QEHKQTARFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIGLWQN 556
Cdd:TIGR00915 479 ALSVLVALILTPALCATMLKpiekgEHHEKKGGFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVR 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 557 TPGSLVPDEDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPAN--ENVVAFTGFDFIGGGykNSAATLFVTQKHWDE 634
Cdd:TIGR00915 559 LPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEKAnvESVFTVNGFSFAGRG--QNMGMAFIRLKDWEE 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 635 R---EVDTKALVQELFMKTAGIKEALVLAFNPPAIFGLGNTGGFEFYIQNKGDSDPDKLQHAMQLMTAEAQKSPIISGLQ 711
Cdd:TIGR00915 637 RtgkENSVFAIAGRATGHFMQIKDAMVIAFVPPAILELGNATGFDFFLQDRAGLGHEALLQARNQLLGLAAQNPALTRVR 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 712 TLWRPDAPQLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQGT 791
Cdd:TIGR00915 717 PNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASGE 796
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 792 MVPLSAFTTIEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAQaVLPPNMTYEWTGSAFQEKRSSGTTGIA 871
Cdd:TIGR00915 797 MVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQ-KLPPGFGFSWTGMSYEERLSGSQAPAL 875
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 872 LGLAVIMVFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYALMKHQQG 951
Cdd:TIGR00915 876 YALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMAQG 955
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 952 WSASTAALEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVPLFFYwLTARKLTEK 1031
Cdd:TIGR00915 956 KSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYV-VVRRLFKRK 1034
|
1050
....*....|
gi 1675103803 1032 RSRQELADEI 1041
Cdd:TIGR00915 1035 AHEKEMSVEH 1044
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
2-1021 |
0e+00 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 1074.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 2 FSRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSS 81
Cdd:pfam00873 1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 82 TSTSAGSTtIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQKGSSSFLQVHAFYSPDGTRSSLWTSNYVTM 161
Cdd:pfam00873 81 QSSYGLSS-ITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRPGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDYADT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 162 NVLDRVKRIPGTTSVQIFGAKDYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIgatpttqSPQELVYSVTAQG 241
Cdd:pfam00873 160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQL-------EGQGLQALIRAQG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 242 RLSEPEQFENIIIRsNTDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFP 321
Cdd:pfam00873 233 QLQSAEDFEKIIVK-NQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFP 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 322 TGLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGM 401
Cdd:pfam00873 312 QGVEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 402 VLSIGIVVDDAIVVLENVERIMHEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAV 481
Cdd:pfam00873 392 VLAIGLVVDDAIVVVENIERVLEENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAI 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 482 SLSGVVALTMTPALCVLILKQEHK-QTARFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIGLWQNTPGS 560
Cdd:pfam00873 472 LLSVLVALTLTPALCATLLKPRREpKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTE 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 561 LVPDEDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPANENVVAFTGFDFIGGGYKNSAATLFVTQKHWDEREVDTK 640
Cdd:pfam00873 552 FLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAFSGDNNGPNSGDAFISLKPWKERPGPEK 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 641 ---ALVQELFMKTAGIKEALVLAFNPPAIFGLGNTGGFEFYIQNK-GDSDPDKLQHAMQLMTAEAQKSPIISGLQTLWRP 716
Cdd:pfam00873 632 svqALIERLRKALKQIPGANVFLFQPIQLRGLGTISGFRSDLQVKiFGDDLDALDEARNQILAALAQLPGLSDVRSDGQE 711
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 717 DAPQLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQGTMVPLS 796
Cdd:pfam00873 712 DQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLS 791
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 797 AFTTIEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAQAV-LPPNMTYEWTGSAFQEKRSSGTTGIALGLA 875
Cdd:pfam00873 792 AFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVkLPPGYGYTWTGQFEQEQLAGNSLPILIALA 871
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 876 VIMVFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYALMKH-QQGWSA 954
Cdd:pfam00873 872 LLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELReQEGKSL 951
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1675103803 955 STAALEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVPLFFY 1021
Cdd:pfam00873 952 EEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYV 1018
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
3-1020 |
0e+00 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 1009.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 3 SRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSST 82
Cdd:PRK09577 2 ARFFIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 83 STSAGSTtIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQKGSSSFLQVHAFYSPDGTRSSLWTSNYVTMN 162
Cdd:PRK09577 82 SSAGQAS-LSLTFKQGVNADLAAVEVQNRLKTVEARLPEPVRRDGIQVEKAADNIQLIVSLTSDDGRLTGVELGEYASAN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 163 VLDRVKRIPGTTSVQIFGAkDYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIGATPTTQSpQELVYSVTAQGR 242
Cdd:PRK09577 161 VLQALRRVEGVGKVQFWGA-EYAMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIGRSAVPDS-APIAATVFADAP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 243 LSEPEQFENIIIRSNTDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFPT 322
Cdd:PRK09577 239 LKTPEDFGAIALRARADGSALYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 323 GLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGMV 402
Cdd:PRK09577 319 GVKYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMV 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 403 LSIGIVVDDAIVVLENVERIMHEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAVS 482
Cdd:PRK09577 399 LAIGILVDDAIVVVENVERLMVEEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIG 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 483 LSGVVALTMTPALCVLILK---QEHKQTARFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIGLWQNTPG 559
Cdd:PRK09577 479 FSAFLALSLTPALCATLLKpvdGDHHEKRGFFGWFNRFVARSTQRYATRVGAILKRPLRWLVVYGALTAAAALLFTRLPT 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 560 SLVPDEDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPANENVVAFTGFDFIGGGykNSAATLFVTQKHWDEREV-- 637
Cdd:PRK09577 559 AFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNLYGEG--PNGGMIFVTLKDWKERKAar 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 638 -DTKALVQELFMKTAGIKEALVLAFNPPAIFGLGNTGGFEFYIQNKGDSDPDKLQHAMQLMTAEAQKSPIISGLQTLWRP 716
Cdd:PRK09577 637 dHVQAIVARINERFAGTPNTTVFAMNSPALPDLGSTSGFDFRLQDRGGLGYAAFVAAREQLLAEGAKDPALTDLMFAGTQ 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 717 DAPQLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQGTMVPLS 796
Cdd:PRK09577 717 DAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKKLRVRNAQGEMVPLA 796
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 797 AFTTIEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAQAvLPPNMTYEWTGSAFQEKRSSGTTGIALGLAV 876
Cdd:PRK09577 797 AFATLHWTLGPPQLTRYNGYPSFTINGSAAPGHSSGEAMAAIERIAAT-LPAGIGYAWSGQSFEERLSGAQAPMLFALSV 875
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 877 IMVFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYALMKHQQGWSAST 956
Cdd:PRK09577 876 LVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVEVAKDLVAQRMSLAD 955
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1675103803 957 AALEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVPLFF 1020
Cdd:PRK09577 956 AALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVITATVLAVFLVPLFF 1019
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
3-1017 |
0e+00 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 810.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 3 SRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSST 82
Cdd:NF033617 1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 83 STSAGSTtIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQKGSS-SFLQVHAFYSPDGTRSSLwtSNYVTM 161
Cdd:NF033617 81 SSLGYST-ITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKANSAdTPIMYIGLTSEEMPRGQL--TDYAER 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 162 NVLDRVKRIPGTTSVQIFGAKDYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIgatpttqSPQELVYSVTAQG 241
Cdd:NF033617 158 VLAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAV-------RGDSVVSTVRAND 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 242 RLSEPEQFENIIIRSNTDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFP 321
Cdd:NF033617 231 QLKTAEDYEDLVIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLP 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 322 TGLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGM 401
Cdd:NF033617 311 KNIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMAL 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 402 VLSIGIVVDDAIVVLENVERimH-EEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIA 480
Cdd:NF033617 391 VLAIGLVVDDAIVVVENIHR--HiEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGA 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 481 VSLSGVVALTMTPALCVLILKQEHKQtARFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIGLWQNTPGS 560
Cdd:NF033617 469 VIISGIVALTLTPMMCSRLLKANEKP-GRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKE 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 561 LVPDEDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPANENVVAFTGfdfiGGGYKNS-AATLFVTQKHWDEREVDT 639
Cdd:NF033617 548 LAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNG----VGGNPGDnTGFGIINLKPWDERDVSA 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 640 KALVQELFMKTAGIKEALVLAFNPPAIFGlGNTGGFEFYIQNKGDSDPDKLQHAMQLMTAEAQKSPIISGLQTLWRPDAP 719
Cdd:NF033617 624 QEIIDRLRPKLAKVPGMDLFLFPLQDLPG-GAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGP 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 720 QLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQGTMVPLSAFT 799
Cdd:NF033617 703 ELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLA 782
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 800 TIEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAQAVLPPNMTYEWTGSAFQEKRSSGTTGIALGLAVIMV 879
Cdd:NF033617 783 KIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKELLPSGISGSFQGAARAFQEEGSSLLFLFLLALAAI 862
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 880 FLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYAL-MKHQQGWSASTAA 958
Cdd:NF033617 863 YLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANeLQRHQGLSRREAI 942
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*....
gi 1675103803 959 LEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVP 1017
Cdd:NF033617 943 YQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLP 1001
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
186-499 |
1.02e-12 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 72.74 E-value: 1.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 186 MRIWLRPDVMSQLGVTVEEIAGAIrvqNSQYAAGKIGaTPTTQSPQ-ELVYSVTAQGRLSePEQFENIIIRSNtDGSSLR 264
Cdd:NF033617 704 LNVDIDRDKAARLGISMQDIGSTL---EVAFGQRQVN-TIYTDGNQyKVVLEVDRRYRLN-PEALNQIYVRSN-DGKLVP 777
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 265 LKDVARVEL--GSKDYNFKGTINgkeAVLLGIFLQPGANaldVAEEVNSVIEEMKSQFPTGLAHLTSYDTTRFVEvSIRE 342
Cdd:NF033617 778 LSTLAKIEEraAPLSLNHFNQFN---SATLSFNLAPGVS---LGEAIEALDQAAKELLPSGISGSFQGAARAFQE-EGSS 850
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 343 VVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGMVLSIGIVVDDAIVVLENVERI 422
Cdd:NF033617 851 LLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANEL 930
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1675103803 423 MHEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAVSLSGVVALTMTPALCVLI 499
Cdd:NF033617 931 QRHQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLL 1007
|
|
| ABC_6TM_MsbA_like |
cd18552 |
Six-transmembrane helical domain of the bacterial ABC lipid flippase MsbA and similar proteins; ... |
329-381 |
6.27e-03 |
|
Six-transmembrane helical domain of the bacterial ABC lipid flippase MsbA and similar proteins; The bacterial lipid flippase MsbA is found in Gram-negative bacteria and transports lipid A and lipopolysaccharide (LPS) from the cytoplasmic leaflet to the periplasmic leaflet of the inner membrane. MsbA is also a polyspecific transporter capable of transporting a broad spectrum of drug molecules. Additionally, MsbA exhibits significant sequence similarity to mammalian multidrug resistance (MDR) proteins such as human MDR protein 1 (MDR1) and LmrA from Lactococcus lactis. This subgroup also contains a putative transporter Brevibacillus brevis TycD; the location of the tycD gene within the Tyc (tyrocidine) biosynthesis operon suggests that TycD may play a role in the secretion of the cyclic decapeptide antibiotic tyrocidine. This transmembrane (TM) subunit possesses the ATP-binding cassette (ABC) exporter fold, which is characterized by 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds, a various type of lipids and polypeptides. ABC transporters typically consist of two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The sequences and structures of the TMDs are quite varied between the different type of transporters, suggesting significant structural diversity of the translocated substrates, while NBDs are conserved among all ABC transporters. The two NBDs together bind and hydrolyze ATP, thereby providing the driving force for transport, while the TMDs participate in substrate recognition and translocation across the lipid membrane by alternating between inward- and outward-facing conformations. Moreover, some ABC genes are organized as half-transporters, which must form either homodimers or heterodimers to form a functional transporter. The ABC exporters play a role in multidrug resistance to antibiotics and anticancer agents, and mutations in these proteins have been shown to cause severe human diseases such as cystic fibrosis.
Pssm-ID: 349996 [Multi-domain] Cd Length: 292 Bit Score: 39.71 E-value: 6.27e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1675103803 329 SYDTTRfVEVSIREVVKTLL-EAMVLVFLVVYLFLQNWRATLI-----PTLAVPVSLLG 381
Cdd:cd18552 103 TNDVNQ-VQNALTSALTVLVrDPLTVIGLLGVLFYLDWKLTLIalvvlPLAALPIRRIG 160
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
1-1023 |
0e+00 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 1236.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 1 MFSRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMS 80
Cdd:COG0841 2 NLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYIT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 81 STSTSAGSTtIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQKGSSSFLQVHAFYSPDGTRSSLwtSNYVT 160
Cdd:COG0841 82 STSSEGSSS-ITVEFELGTDIDEALVDVQNAVDRARSDLPEDVEPPGVTKVNPSDFPVMVLALSSDDLDELEL--SDYAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 161 MNVLDRVKRIPGTTSVQIFGAKDYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIGAtpttqspQELVYSVTAQ 240
Cdd:COG0841 159 RNIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGG-------GDREYTVRTN 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 241 GRLSEPEQFENIIIRSNtDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQF 320
Cdd:COG0841 232 GRLKTPEEFENIVIRTN-DGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 321 PTGLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFG 400
Cdd:COG0841 311 PEGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFA 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 401 MVLSIGIVVDDAIVVLENVERIMhEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIA 480
Cdd:COG0841 391 LVLAIGIVVDDAIVVVENIERHM-EEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIA 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 481 VSLSGVVALTMTPALCVLILKQEHK-QTARFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIGLWQNTPG 559
Cdd:COG0841 470 LLISLFVALTLTPALCARLLKPHPKgKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPT 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 560 SLVPDEDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPANENVVAFTGFDFIGGGykNSAATLFVTQKHWDEREVDT 639
Cdd:COG0841 550 EFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSG--SNSGTIFVTLKPWDERDRSA 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 640 KALVQELFMKTAGIKEALVLAFNPPAIfGLGNTGGFEFYIQnkgDSDPDKLQHAMQLMTAEAQKSPIISGLQTLWRPDAP 719
Cdd:COG0841 628 DEIIARLREKLAKIPGARVFVFQPPAG-GLGSGAPIEVQLQ---GDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKP 703
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 720 QLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQGTMVPLSAFT 799
Cdd:COG0841 704 ELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVA 783
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 800 TIEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAQA-VLPPNMTYEWTGSAFQEKRSSGTTGIALGLAVIM 878
Cdd:COG0841 784 TIEEGTGPSSINRYNGQRSVTVSANLAPGVSLGEALAAIEELAAElKLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLL 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 879 VFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYALMKHQQGWSASTAA 958
Cdd:COG0841 864 VYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLREEGMSLREAI 943
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1675103803 959 LEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVPLFFYWL 1023
Cdd:COG0841 944 LEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLL 1008
|
|
| 2A0602 |
TIGR00915 |
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ... |
2-1041 |
0e+00 |
|
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]
Pssm-ID: 273335 [Multi-domain] Cd Length: 1044 Bit Score: 1183.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 2 FSRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSS 81
Cdd:TIGR00915 1 MAKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 82 TSTSAGSTTIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQKGSSSFLQVHAFYSPDGTRSSLWTSNYVTM 161
Cdd:TIGR00915 81 SSDSDGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGVRVEKASSNFLMVIGLVSDDGSMTKEDLSDYAAS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 162 NVLDRVKRIPGTTSVQIFGAKdYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIGATPTTQSpQELVYSVTAQG 241
Cdd:TIGR00915 161 NMVDPLSRLEGVGDVQLFGSQ-YAMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLGGLPAVPG-QQLNATIIAQT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 242 RLSEPEQFENIIIRSNTDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFP 321
Cdd:TIGR00915 239 RLQTPEQFENILLKVNTDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 322 TGLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGM 401
Cdd:TIGR00915 319 QGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAM 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 402 VLSIGIVVDDAIVVLENVERIMHEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAV 481
Cdd:TIGR00915 399 VLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAM 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 482 SLSGVVALTMTPALCVLILK-----QEHKQTARFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIGLWQN 556
Cdd:TIGR00915 479 ALSVLVALILTPALCATMLKpiekgEHHEKKGGFFGWFNRMFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLFVR 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 557 TPGSLVPDEDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPAN--ENVVAFTGFDFIGGGykNSAATLFVTQKHWDE 634
Cdd:TIGR00915 559 LPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEKAnvESVFTVNGFSFAGRG--QNMGMAFIRLKDWEE 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 635 R---EVDTKALVQELFMKTAGIKEALVLAFNPPAIFGLGNTGGFEFYIQNKGDSDPDKLQHAMQLMTAEAQKSPIISGLQ 711
Cdd:TIGR00915 637 RtgkENSVFAIAGRATGHFMQIKDAMVIAFVPPAILELGNATGFDFFLQDRAGLGHEALLQARNQLLGLAAQNPALTRVR 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 712 TLWRPDAPQLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQGT 791
Cdd:TIGR00915 717 PNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVRNASGE 796
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 792 MVPLSAFTTIEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAQaVLPPNMTYEWTGSAFQEKRSSGTTGIA 871
Cdd:TIGR00915 797 MVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQ-KLPPGFGFSWTGMSYEERLSGSQAPAL 875
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 872 LGLAVIMVFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYALMKHQQG 951
Cdd:TIGR00915 876 YALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMAQG 955
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 952 WSASTAALEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVPLFFYwLTARKLTEK 1031
Cdd:TIGR00915 956 KSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYV-VVRRLFKRK 1034
|
1050
....*....|
gi 1675103803 1032 RSRQELADEI 1041
Cdd:TIGR00915 1035 AHEKEMSVEH 1044
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
2-1021 |
0e+00 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 1074.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 2 FSRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSS 81
Cdd:pfam00873 1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 82 TSTSAGSTtIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQKGSSSFLQVHAFYSPDGTRSSLWTSNYVTM 161
Cdd:pfam00873 81 QSSYGLSS-ITLTFELGTDIDIARQDVQNRLQLATPLLPEGVQRPGISVIKTSLGPIMVLAVTSPDGSYTQTDLRDYADT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 162 NVLDRVKRIPGTTSVQIFGAKDYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIgatpttqSPQELVYSVTAQG 241
Cdd:pfam00873 160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQL-------EGQGLQALIRAQG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 242 RLSEPEQFENIIIRsNTDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFP 321
Cdd:pfam00873 233 QLQSAEDFEKIIVK-NQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFP 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 322 TGLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGM 401
Cdd:pfam00873 312 QGVEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGL 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 402 VLSIGIVVDDAIVVLENVERIMHEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAV 481
Cdd:pfam00873 392 VLAIGLVVDDAIVVVENIERVLEENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAI 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 482 SLSGVVALTMTPALCVLILKQEHK-QTARFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIGLWQNTPGS 560
Cdd:pfam00873 472 LLSVLVALTLTPALCATLLKPRREpKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTE 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 561 LVPDEDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPANENVVAFTGFDFIGGGYKNSAATLFVTQKHWDEREVDTK 640
Cdd:pfam00873 552 FLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFAFSGDNNGPNSGDAFISLKPWKERPGPEK 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 641 ---ALVQELFMKTAGIKEALVLAFNPPAIFGLGNTGGFEFYIQNK-GDSDPDKLQHAMQLMTAEAQKSPIISGLQTLWRP 716
Cdd:pfam00873 632 svqALIERLRKALKQIPGANVFLFQPIQLRGLGTISGFRSDLQVKiFGDDLDALDEARNQILAALAQLPGLSDVRSDGQE 711
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 717 DAPQLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQGTMVPLS 796
Cdd:pfam00873 712 DQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLS 791
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 797 AFTTIEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAQAV-LPPNMTYEWTGSAFQEKRSSGTTGIALGLA 875
Cdd:pfam00873 792 AFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVkLPPGYGYTWTGQFEQEQLAGNSLPILIALA 871
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 876 VIMVFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYALMKH-QQGWSA 954
Cdd:pfam00873 872 LLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELReQEGKSL 951
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1675103803 955 STAALEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVPLFFY 1021
Cdd:pfam00873 952 EEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYV 1018
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
3-1020 |
0e+00 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 1009.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 3 SRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSST 82
Cdd:PRK09577 2 ARFFIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 83 STSAGSTtIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQKGSSSFLQVHAFYSPDGTRSSLWTSNYVTMN 162
Cdd:PRK09577 82 SSAGQAS-LSLTFKQGVNADLAAVEVQNRLKTVEARLPEPVRRDGIQVEKAADNIQLIVSLTSDDGRLTGVELGEYASAN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 163 VLDRVKRIPGTTSVQIFGAkDYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIGATPTTQSpQELVYSVTAQGR 242
Cdd:PRK09577 161 VLQALRRVEGVGKVQFWGA-EYAMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIGRSAVPDS-APIAATVFADAP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 243 LSEPEQFENIIIRSNTDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFPT 322
Cdd:PRK09577 239 LKTPEDFGAIALRARADGSALYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 323 GLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGMV 402
Cdd:PRK09577 319 GVKYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMV 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 403 LSIGIVVDDAIVVLENVERIMHEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAVS 482
Cdd:PRK09577 399 LAIGILVDDAIVVVENVERLMVEEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIG 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 483 LSGVVALTMTPALCVLILK---QEHKQTARFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIGLWQNTPG 559
Cdd:PRK09577 479 FSAFLALSLTPALCATLLKpvdGDHHEKRGFFGWFNRFVARSTQRYATRVGAILKRPLRWLVVYGALTAAAALLFTRLPT 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 560 SLVPDEDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPANENVVAFTGFDFIGGGykNSAATLFVTQKHWDEREV-- 637
Cdd:PRK09577 559 AFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNLYGEG--PNGGMIFVTLKDWKERKAar 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 638 -DTKALVQELFMKTAGIKEALVLAFNPPAIFGLGNTGGFEFYIQNKGDSDPDKLQHAMQLMTAEAQKSPIISGLQTLWRP 716
Cdd:PRK09577 637 dHVQAIVARINERFAGTPNTTVFAMNSPALPDLGSTSGFDFRLQDRGGLGYAAFVAAREQLLAEGAKDPALTDLMFAGTQ 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 717 DAPQLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQGTMVPLS 796
Cdd:PRK09577 717 DAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKKLRVRNAQGEMVPLA 796
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 797 AFTTIEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAQAvLPPNMTYEWTGSAFQEKRSSGTTGIALGLAV 876
Cdd:PRK09577 797 AFATLHWTLGPPQLTRYNGYPSFTINGSAAPGHSSGEAMAAIERIAAT-LPAGIGYAWSGQSFEERLSGAQAPMLFALSV 875
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 877 IMVFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYALMKHQQGWSAST 956
Cdd:PRK09577 876 LVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVEVAKDLVAQRMSLAD 955
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1675103803 957 AALEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVPLFF 1020
Cdd:PRK09577 956 AALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVITATVLAVFLVPLFF 1019
|
|
| PRK15127 |
PRK15127 |
multidrug efflux RND transporter permease subunit AcrB; |
3-1049 |
0e+00 |
|
multidrug efflux RND transporter permease subunit AcrB;
Pssm-ID: 185081 [Multi-domain] Cd Length: 1049 Bit Score: 1003.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 3 SRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSST 82
Cdd:PRK15127 2 PNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 83 STSAGSTTIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQKGSSSFLQVHAFYSPDGTRSSLWTSNYVTMN 162
Cdd:PRK15127 82 SDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAAN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 163 VLDRVKRIPGTTSVQIFGAKdYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIGATPTTQSpQELVYSVTAQGR 242
Cdd:PRK15127 162 MKDPISRTSGVGDVQLFGSQ-YAMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQLGGTPPVKG-QQLNASIIAQTR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 243 LSEPEQFENIIIRSNTDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFPT 322
Cdd:PRK15127 240 LTSTEEFGKILLKVNQDGSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPS 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 323 GLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGMV 402
Cdd:PRK15127 320 GLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMV 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 403 LSIGIVVDDAIVVLENVERIMHEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAVS 482
Cdd:PRK15127 400 LAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMA 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 483 LSGVVALTMTPALCVLILKQ----EH-KQTARFFLWFNDMFTKITGRYVGAVGFMVRRG----LLGLILMTGMIAatigL 553
Cdd:PRK15127 480 LSVLVALILTPALCATMLKPiakgDHgEGKKGFFGWFNRMFEKSTHHYTDSVGNILRSTgrylVLYLIIVVGMAY----L 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 554 WQNTPGSLVPDEDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPAN--ENVVAFTGFDFIGGGYKNSAAtlFVTQKH 631
Cdd:PRK15127 556 FVRLPSSFLPDEDQGVFLTMVQLPAGATQERTQKVLNEVTDYYLTKEKNnvESVFAVNGFGFAGRGQNTGIA--FVSLKD 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 632 WDER---EVDTKALVQELFMKTAGIKEALVLAFNPPAIFGLGNTGGFEFYIQNKGDSDPDKLQHAMQLMTAEAQKSP-II 707
Cdd:PRK15127 634 WADRpgeENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLGEAAKHPdML 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 708 SGLQTLWRPDAPQLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKN 787
Cdd:PRK15127 714 VGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRA 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 788 NQGTMVPLSAFTTIEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAqAVLPPNMTYEWTGSAFQEkRSSGT 867
Cdd:PRK15127 794 ADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEELA-SKLPTGVGYDWTGMSYQE-RLSGN 871
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 868 TGIAL-GLAVIMVFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYA-- 944
Cdd:PRK15127 872 QAPALyAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAkd 951
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 945 LMKhQQGWSASTAALEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVPLFFYwLT 1024
Cdd:PRK15127 952 LMD-KEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFV-VV 1029
|
1050 1060
....*....|....*....|....*
gi 1675103803 1025 ARKLTEKrsrqelADEIAAHHQQEH 1049
Cdd:PRK15127 1030 RRRFSRK------NEDIEHSHTVDH 1048
|
|
| PRK10555 |
PRK10555 |
multidrug efflux RND transporter permease AcrD; |
3-1026 |
0e+00 |
|
multidrug efflux RND transporter permease AcrD;
Pssm-ID: 182544 [Multi-domain] Cd Length: 1037 Bit Score: 999.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 3 SRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSST 82
Cdd:PRK10555 2 ANFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 83 STSAGSTTIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQK-GSSSFLQVhAFYSPDGTRSSLWTSNYVTM 161
Cdd:PRK10555 82 SSGTGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGVTVRKtGDTNILTI-AFVSTDGSMDKQDIADYVAS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 162 NVLDRVKRIPGTTSVQIFGAKdYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIGATPTTQSpQELVYSVTAQG 241
Cdd:PRK10555 161 NIQDPLSRVNGVGDIDAYGSQ-YSMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQLGGTPSVDK-QALNATINAQS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 242 RLSEPEQFENIIIRSNTDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFP 321
Cdd:PRK10555 239 LLQTPEQFRDITLRVNQDGSEVTLGDVATVELGAEKYDYLSRFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQYFP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 322 TGLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGM 401
Cdd:PRK10555 319 HGLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAM 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 402 VLSIGIVVDDAIVVLENVERIMHEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAV 481
Cdd:PRK10555 399 VLAIGLLVDDAIVVVENVERIMSEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAM 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 482 SLSGVVALTMTPALCVLILKQ----EHKQTARFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIGLWQNT 557
Cdd:PRK10555 479 VLSVLVAMILTPALCATLLKPlkkgEHHGQKGFFGWFNRMFNRNAERYEKGVAKILHRSLRWILIYVLLLGGMVFLFLRL 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 558 PGSLVPDEDQGYYISAIFLPDGSSLERTEQVTQQvVEAVQSNPANENVVAFtgFDFIG---GGYKNSAATLFVTQKHWDE 634
Cdd:PRK10555 559 PTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEK-VEKYYFTHEKDNVMSV--FATVGsgpGGNGQNVARMFIRLKDWDE 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 635 REVDTK---ALVQELFMKTAGIKEALVLAFNPPAIFGLGNTGGFEFYIQNKGDSDPDKLQHAMQLMTAEAQKSPIISGLQ 711
Cdd:PRK10555 636 RDSKTGtsfAIIERATKAFNKIKEARVIASSPPAISGLGSSAGFDMELQDHAGAGHDALMAARNQLLALAAKNPELTRVR 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 712 TLWRPDAPQLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQGT 791
Cdd:PRK10555 716 HNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYVRNKDGG 795
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 792 MVPLSAFTTIEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAQAvLPPNMTYEWTGSAFQEkRSSGTTGIA 871
Cdd:PRK10555 796 MVPFSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVKQ-LPNGFGLEWTAMSYQE-RLSGAQAPA 873
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 872 L-GLAVIMVFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYALMKHQQ 950
Cdd:PRK10555 874 LyAISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQK 953
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1675103803 951 GWSASTAALEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVPLFFYWLTAR 1026
Cdd:PRK10555 954 GHDLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATILAIFFVPLFFVLVRRR 1029
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
3-1017 |
0e+00 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 810.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 3 SRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSST 82
Cdd:NF033617 1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 83 STSAGSTtIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQKGSS-SFLQVHAFYSPDGTRSSLwtSNYVTM 161
Cdd:NF033617 81 SSLGYST-ITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKANSAdTPIMYIGLTSEEMPRGQL--TDYAER 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 162 NVLDRVKRIPGTTSVQIFGAKDYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIgatpttqSPQELVYSVTAQG 241
Cdd:NF033617 158 VLAPKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAV-------RGDSVVSTVRAND 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 242 RLSEPEQFENIIIRSNTDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFP 321
Cdd:NF033617 231 QLKTAEDYEDLVIKYADNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLP 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 322 TGLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGM 401
Cdd:NF033617 311 KNIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMAL 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 402 VLSIGIVVDDAIVVLENVERimH-EEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIA 480
Cdd:NF033617 391 VLAIGLVVDDAIVVVENIHR--HiEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGA 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 481 VSLSGVVALTMTPALCVLILKQEHKQtARFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIGLWQNTPGS 560
Cdd:NF033617 469 VIISGIVALTLTPMMCSRLLKANEKP-GRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKE 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 561 LVPDEDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPANENVVAFTGfdfiGGGYKNS-AATLFVTQKHWDEREVDT 639
Cdd:NF033617 548 LAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNG----VGGNPGDnTGFGIINLKPWDERDVSA 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 640 KALVQELFMKTAGIKEALVLAFNPPAIFGlGNTGGFEFYIQNKGDSDPDKLQHAMQLMTAEAQKSPIISGLQTLWRPDAP 719
Cdd:NF033617 624 QEIIDRLRPKLAKVPGMDLFLFPLQDLPG-GAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGP 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 720 QLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQGTMVPLSAFT 799
Cdd:NF033617 703 ELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLA 782
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 800 TIEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAQAVLPPNMTYEWTGSAFQEKRSSGTTGIALGLAVIMV 879
Cdd:NF033617 783 KIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKELLPSGISGSFQGAARAFQEEGSSLLFLFLLALAAI 862
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 880 FLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYAL-MKHQQGWSASTAA 958
Cdd:NF033617 863 YLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANeLQRHQGLSRREAI 942
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*....
gi 1675103803 959 LEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVP 1017
Cdd:NF033617 943 YQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLP 1001
|
|
| PRK09579 |
PRK09579 |
multidrug efflux RND transporter permease subunit; |
2-1036 |
0e+00 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169983 [Multi-domain] Cd Length: 1017 Bit Score: 593.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 2 FSRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSS 81
Cdd:PRK09579 3 FTDPFIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 82 TSTSAGSTtIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQKGSSSFLQVHAFYSpdGTRSSLWTSNYVTM 161
Cdd:PRK09579 83 VSRQNFSI-ISIYARIGADSDRLFTELLAKANEVKNQLPQDAEDPVLSKEAADASALMYISFYS--EEMSNPQITDYLSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 162 NVLDRVKRIPGTTSVQIFGAKDYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIGAtpttqspQELVYSVTAQG 241
Cdd:PRK09579 160 VIQPKLATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKG-------EYVVTSINAST 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 242 RLSEPEQFENIIIRSNTDgSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFP 321
Cdd:PRK09579 233 ELKSAEAFAAIPVKTSGD-SRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLP 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 322 TGLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGM 401
Cdd:PRK09579 312 PNLKVSIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAM 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 402 VLSIGIVVDDAIVVLENVERIMhEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAV 481
Cdd:PRK09579 392 VLAIGLVVDDAIVVVENIHRHI-EEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAV 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 482 SLSGVVALTMTPALCVLILKQEHKQTArFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIGLWQNTPGSL 561
Cdd:PRK09579 471 IISGIVALTLSPMMCALLLRHEENPSG-LAHRLDRLFERLKQRYQRALHGTLNTRPVVLVFAVIVLALIPVLLKFTQSEL 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 562 VPDEDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPANENVVAFTGFDFIGGGYKNsaatlfVTQKHWDEREVDTKA 641
Cdd:PRK09579 550 APEEDQGIIFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQINGFNGVQSGIGG------FLLKPWNERERTQME 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 642 LVQELFMKTAGIKEALVLAFNPPAIFGLGNTGGFEFYIQNKGDSdpDKLQHAMQLMTAEAQKSPIISGLQTLWRPDAPQL 721
Cdd:PRK09579 624 LLPLVQAKLEEIPGLQIFGFNLPSLPGTGEGLPFQFVINTANDY--ESLLQVAQRVKQRAQESGKFAFLDIDLAFDKPEV 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 722 RVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQGTMVPLSAFTTI 801
Cdd:PRK09579 702 VVDIDRAKAAQMGVSMQDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPYRDNPGWLNNYYVKNEQGQLLPLSTLITL 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 802 EYSRGPENLNRYNNLPAVKLMGnaAPGYSSGQAIAEVERIAQAVLPPNMTYEWTGSAFQEKRSSGTTGIALGLAVIMVFL 881
Cdd:PRK09579 782 SDRARPRQLNQFQQLNSAIISG--FPIVSMGEAIETVQQIAREEAPEGFAFDYAGASRQYVQEGSALWVTFGLALAIIFL 859
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 882 ILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYA-LMKHQQGWSASTAALE 960
Cdd:PRK09579 860 VLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEFAnQLRHEQGLSRREAIEE 939
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1675103803 961 AARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVPLfFYWLTARKLTEKRSRQE 1036
Cdd:PRK09579 940 AAAIRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPC-IYTLLAKPDAAPGVAQA 1014
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
4-1032 |
4.48e-153 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 481.84 E-value: 4.48e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 4 RYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSSTS 83
Cdd:COG3696 7 RFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVKEVRSIS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 84 TSAGSTtIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEetrrqGVVVQKG--SSSFLQV--HAFYSPDGTRS-----SL- 153
Cdd:COG3696 87 RFGLSV-VTVIFEDGTDIYWARQLVLERLQQVREQLPA-----GVTPELGpiSTGLGEIyqYTLESDPGKYSlmelrTLq 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 154 -WTSNYvtmnvldRVKRIPGTTSVQIFG--AKDYamRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIgatptTQSP 230
Cdd:COG3696 161 dWVIRP-------QLRSVPGVAEVNSFGgfVKQY--QVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYI-----ERGG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 231 QELVysVTAQGRLSEPEQFENIIIRSNtDGSSLRLKDVARVELGSKDYNFKGTINGK-EAVLLGIFLQPGANALDVAEEV 309
Cdd:COG3696 227 QEYL--VRGIGLIRSLEDIENIVVKTR-NGTPVLLRDVAEVRIGPAPRRGAATLNGEgEVVGGIVLMLKGENALEVIEAV 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 310 NSVIEEMKSQFPTGLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYML 389
Cdd:COG3696 304 KAKLAELKPSLPEGVKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLF 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 390 GYSINSLTLFGMVLSIGIVVDDAIVVLENVERIMHEEGLGAR-----EAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGG 464
Cdd:COG3696 384 GISANLMSLGGLAIDFGIIVDGAVVMVENILRRLEENRAAGTprerlEVVLEAAREVRRPIFFATLIIILVFLPIFTLEG 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 465 LTGELFRQFAITISIAVSLSGVVALTMTPALCVLILK--QEHKQTarfflWFNDMFTKItgrYVGAVGFMVRRGLLGLIL 542
Cdd:COG3696 464 VEGKLFRPMALTVIFALLGALLLSLTLVPVLASLLLRgkVPEKEN-----PLVRWLKRL---YRPLLRWALRHPKLVLAV 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 543 MTGMIAATIGLWQNTPGSLVPDEDQG-YYISAIFLPdGSSLERTEQVTQQVVEAVQSNPANENVVAFTGFDFIGG---GY 618
Cdd:COG3696 536 ALVLLVLALALFPRLGSEFLPELDEGdLLVMATLPP-GISLEESVELGQQVERILKSFPEVESVVSRTGRAEDATdpmGV 614
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 619 knSAATLFVTQKHWDE--REVDTKALVQELfmktagikEALVLAFnPpaifglGNTGGFEFYIQN---------KGD--- 684
Cdd:COG3696 615 --NMSETFVILKPRSEwrSGRTKEELIAEM--------REALEQI-P------GVNFNFSQPIQMrvdellsgvRADvav 677
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 685 ----SDPDKLQHAMQLMTAEAQKSPIISGLQTLWRPDAPQLRVDVDREQARAMGVEIDDAF----TALAG-NLGTYYVND 755
Cdd:COG3696 678 kifgDDLDVLRRLAEQIEAVLKTVPGAADVQVERVTGLPQLDIRIDRDAAARYGLNVADVQdvveTAIGGkAVGQVYEGE 757
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 756 fnkfgRAWQVLMSADAEFRMKPDDIGRIYVKNNQGTMVPLSAFTTIEYSRGPENLNRYNNLPAVKLMGNAApGYSSGQAI 835
Cdd:COG3696 758 -----RRFDIVVRLPEELRDDPEAIRNLPIPTPSGAQVPLSQVADIEVVEGPNQISRENGRRRIVVQANVR-GRDLGSFV 831
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 836 AEV-ERIAQAV-LPPNMTYEWTGSAFQEKRSSGTTGIALGLAVIMVFLILAALYERWSLPLSVMLALPFGTFGALIAVWV 913
Cdd:COG3696 832 AEAqAKVAEQVkLPPGYYIEWGGQFENLQRATARLAIVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWL 911
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 914 VGMtndvYFQI----GLVTLLGLASKNAILIVEYALMKHQQGWSASTAALEAARLRFRPIIMTSLAFILGVVPLVLSSGA 989
Cdd:COG3696 912 RGM----PLSVsagvGFIALFGVAVLNGVVLVSYINQLRAEGLDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGP 987
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|...
gi 1675103803 990 GAGARHSVGTGVMGGMMAATFLAVFFVPLFFYWLTARKLTEKR 1032
Cdd:COG3696 988 GSEVQRPLATVVIGGLITSTLLTLLVLPALYLLFGRRRLRRAA 1030
|
|
| PRK10614 |
PRK10614 |
multidrug efflux system subunit MdtC; Provisional |
6-1035 |
2.71e-139 |
|
multidrug efflux system subunit MdtC; Provisional
Pssm-ID: 182589 [Multi-domain] Cd Length: 1025 Bit Score: 445.33 E-value: 2.71e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 6 FIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSSTSTS 85
Cdd:PRK10614 7 FIYRPVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 86 AGSTTIeVTFEIGTDVDQAAVNVNNRVKQVEARLPEET-RRQGVVVQKGSSSFLQVHAFYSPDGTRSSLWtsNYVTMNVL 164
Cdd:PRK10614 87 GSTRII-LQFDFDRDINGAARDVQAAINAAQSLLPSGMpSRPTYRKANPSDAPIMILTLTSDTYSQGQLY--DFASTQLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 165 DRVKRIPGTTSVQIFGAKDYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIgatpttqSPQELVYSVTAQGRLS 244
Cdd:PRK10614 164 QTISQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAV-------EDGTHRWQIQTNDELK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 245 EPEQFENIIIRSNtDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFPTGL 324
Cdd:PRK10614 237 TAAEYQPLIIHYN-NGAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIPAAI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 325 AHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGMVLS 404
Cdd:PRK10614 316 DLQIAQDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIA 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 405 IGIVVDDAIVVLENVERIMhEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAVSLS 484
Cdd:PRK10614 396 TGFVVDDAIVVLENISRHL-EAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGIS 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 485 GVVALTMTPALCVLILKQEHKQTARFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIGLWQNTPGSLVPD 564
Cdd:PRK10614 475 LLVSLTLTPMMCAWLLKSSKPREQKRLRGFGRMLVALQQGYGRSLKWVLNHTRWVGVVLLGTIALNVWLYISIPKTFFPE 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 565 EDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPANENVVAFTgfdfiGGGYKNSAAtLFVTQKHWDEREVDTKALVQ 644
Cdd:PRK10614 555 QDTGRLMGFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFT-----GGSRVNSGM-MFITLKPLSERSETAQQVID 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 645 ELFMKTAgiKEA----LVLAFNPPAIFGLGNTGGFEFYIQNkgdSDPDKLQHAMQLMTAEAQKSPIISGLQTLWRPDAPQ 720
Cdd:PRK10614 629 RLRVKLA--KEPganlFLMAVQDIRVGGRQSNASYQYTLLS---DDLAALREWEPKIRKALAALPELADVNSDQQDKGAE 703
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 721 LRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQGTMVPLSAFTT 800
Cdd:PRK10614 704 MALTYDRDTMARLGIDVQAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAK 783
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 801 IEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAQAVLPPNM---TYEWTGSAFQEKRSSGTTGIAlgLAVI 877
Cdd:PRK10614 784 WQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIERAMTQLGVPSTvrgSFAGTAQVFQETMNSQLILIL--AAIA 861
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 878 MVFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYALMKHQQG-WSAST 956
Cdd:PRK10614 862 TVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNGnLTAQE 941
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1675103803 957 AALEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVPLFFywLTARKLTEKRSRQ 1035
Cdd:PRK10614 942 AIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVVY--LFFDRLRLRFSRK 1018
|
|
| PRK10503 |
PRK10503 |
MdtB/MuxB family multidrug efflux RND transporter permease subunit; |
3-1020 |
5.75e-138 |
|
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
Pssm-ID: 182501 [Multi-domain] Cd Length: 1040 Bit Score: 442.25 E-value: 5.75e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 3 SRYFIDRPIFAFVISIVIVLAGLAAMRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSST 82
Cdd:PRK10503 13 SRLFILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQFGQMSGLKQMSSQ 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 83 STSAGSTtIEVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVvvqkgsssFLQVHAFYSPDGTRSSLWTS------ 156
Cdd:PRK10503 93 SSGGASV-ITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPV--------YSKVNPADPPIMTLAVTSTAmpmtqv 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 157 -NYVTMNVLDRVKRIPGTTSVQIFGAKDYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIGAtPTTqspqelvy 235
Cdd:PRK10503 164 eDMVETRVAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDG-PTR-------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 236 SVT--AQGRLSEPEQFENIIIrSNTDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVI 313
Cdd:PRK10503 235 AVTlsANDQMQSAEEYRQLII-AYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQML 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 314 EEMKSQFPTGLAHLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSI 393
Cdd:PRK10503 314 PQLTESLPKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSI 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 394 NSLTLFGMVLSIGIVVDDAIVVLENVERIMhEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQF 473
Cdd:PRK10503 394 NNLTLMALTIATGFVVDDAIVVIENISRYI-EKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREF 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 474 AITISIAVSLSGVVALTMTPALCVLILKQEH-KQTARFFLWFNDMFTKITGRYVGAVGFMVRRGLLGLILMTGMIAATIG 552
Cdd:PRK10503 473 AVTLAVAILISAVVSLTLTPMMCARMLSQESlRKQNRFSRASERMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVL 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 553 LWQNTPGSLVPDEDQGYYISAIFLPDGSSLERTEQVTQQVVEAVQSNPANENVVAFTGFDfiGGGYKNSAATLFVTQKHW 632
Cdd:PRK10503 553 LWIFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVD--GTNPSLNSARLQINLKPL 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 633 DEREVDTKALVQELFMKTAGIKeALVLAFNPPAIFGLGNTGG---FEFYIQNkgdSDPDKLQHAMQLMTAEAQKSPIISG 709
Cdd:PRK10503 631 DERDDRVQKVIARLQTAVAKVP-GVDLYLQPTQDLTIDTQVSrtqYQFTLQA---TSLDALSTWVPKLMEKLQQLPQLSD 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 710 LQTLWRPDAPQLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRMKPDDIGRIYVKNNQ 789
Cdd:PRK10503 707 VSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSD 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 790 GTMVPLSAFTTIEYSRGPENLNRYNNLPAVKLMGNAAPGYSSGQAIAEVERIAQAV-LPPNMTYEWTGSAFQEKRSSGTT 868
Cdd:PRK10503 787 GGVVPLSSIATIEQRFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTLnLPADITTQFQGSTLAFQSALGST 866
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 869 GIALGLAVIMVFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYAL-MK 947
Cdd:PRK10503 867 VWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALaAE 946
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1675103803 948 HQQGWSASTAALEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAATFLAVFFVPLFF 1020
Cdd:PRK10503 947 REQGMSPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIY 1019
|
|
| 2A0601 |
TIGR00914 |
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ... |
14-1039 |
4.72e-95 |
|
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129992 [Multi-domain] Cd Length: 1051 Bit Score: 325.95 E-value: 4.72e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 14 FVISIVIVLAGLAA--MRSLPVAQYPEIAPPVVQVTAAYPGASADVLEQTVATPIENAITGVEGMMYMSSTSTSAGSTtI 91
Cdd:TIGR00914 15 LVLLATLVMAILGIwsYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLETTRSLSRYGLSQ-V 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 92 EVTFEIGTDVDQAAVNVNNRVKQVEARLPEETRRQGVVVQKGSSSFLQVHAFYSPDGTRSSLWTSNYVTMNVLD------ 165
Cdd:TIGR00914 94 TVIFKDGTDLYFARQLVNERLQQARDNLPEGVSPEMGPISTGLGEIFLYTVEAEEGARKKDGGAYTLTDLRTIQdwiirp 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 166 RVKRIPGTTSVQIFGAKDYAMRIWLRPDVMSQLGVTVEEIAGAIRVQNSQYAAGKIgatpttqSPQELVYSVTAQGRLSE 245
Cdd:TIGR00914 174 QLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYI-------ERRGEQYLVRAPGQVQS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 246 PEQFENIIIrSNTDGSSLRLKDVARVELGSKDYNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFPTGLA 325
Cdd:TIGR00914 247 MDDIRNIVI-ATGEGVPIRIRDVARVQIGKELRTGAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETINKTLPEGVE 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 326 HLTSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLfgMVLSI 405
Cdd:TIGR00914 326 IVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSL--GALDF 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 406 GIVVDDAIVVLENVERIM----HEEG----LGAR-EAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAIT 476
Cdd:TIGR00914 404 GLIVDGAVVIVENAHRRLaeaqHHHGrqltLKERlHEVFAASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPMAFT 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 477 ISIAVSLSGVVALTMTPALCVLILKQEHKQTA-RFFLWFNDMFTKITGRYVGAVGFMVRRGLLgLILMTGMIAATIGlwq 555
Cdd:TIGR00914 484 VVLALAGAMILSLTFVPAAVALFIRGKVAEKEnRLMRVLKRRYEPLLERVLAWPAVVLGAAAV-SIVLVVWIASRVG--- 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 556 ntpGSLVPDEDQG-YYISAIFLPdGSSLERTEQVTQQVVEAVQSNPANENVVAFTGfdfigggyKNSAAT---------- 624
Cdd:TIGR00914 560 ---GEFIPSLNEGdLAYQALRIP-GTSLAQSVAMQQTLEKLIKSFPEVARVFAKTG--------TAEIATdpmppnasdt 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 625 --LFVTQKHWDEREVDTKALVQELFMKTAGIKeALVLAFNPPA-------IFGLGNTGGFEFYiqnkGDsDPDKLQHAMQ 695
Cdd:TIGR00914 628 yiILKPESQWPEGKKTKEDLIEEIQEATVRIP-GNNYEFTQPIqmrfnelISGVRSDVAVKVF----GD-DLDDLDATAE 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 696 LMTAEAQKSPIISGLQTLWRPDAPQLRVDVDREQARAMGVEIDDAFTALAGNLGTYYVNDFNKFGRAWQVLMSADAEFRM 775
Cdd:TIGR00914 702 KISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRE 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 776 KPDDIGRIYV-----KNNQGTMVPLSAFTTIEYSRGPENLNRYNNLPAVKLMGNAApGYSSGQAIAEVE-RIAQAV-LPP 848
Cdd:TIGR00914 782 SPQALRQLPIplplsEDARKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVR-GRDLGSFVDDAKkAIAEQVkLPP 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 849 NMTYEWTGSAFQEKRSSGTTGIALGLAVIMVFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTNDVYFQIGLVT 928
Cdd:TIGR00914 861 GYWITWGGQFEQLQSATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIA 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 929 LLGLASKNAILIVEYALMKHQQGWSASTAALEAARLRFRPIIMTSLAFILGVVPLVLSSGAGAGARHSVGTGVMGGMMAA 1008
Cdd:TIGR00914 941 LSGVAVLNGLVMISFIRKLLEEGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITA 1020
|
1050 1060 1070
....*....|....*....|....*....|.
gi 1675103803 1009 TFLAVFFVPLFFYWLTARKlTEKRSRQELAD 1039
Cdd:TIGR00914 1021 TLLTLFVLPALYRLVHRRR-HKGRKEHEPLE 1050
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
285-1023 |
3.63e-27 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 118.81 E-value: 3.63e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 285 NGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKSQFPTGLAHL----TSYDTTRFVEVSIREVVKTLLEAMVLVFLVVYL 360
Cdd:COG1033 158 DGKATLIVVTLDPDPLSSDLDRKEVVAEIRAIIAKYEDPGVEVyltgFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFL 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 361 FLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGMVLSIGIVVDDAIVVLenvERIMHE--EGLGAREAAVKAM 438
Cdd:COG1033 238 FFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLL---NRYREErrKGLDKREALREAL 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 439 GEVSGPVvaivlVLCSVFVPIAFLGGLTGEL--FRQFAITISIAVSLSGVVALTMTPALCVLILKQEHKQTARFFLWFND 516
Cdd:COG1033 315 RKLGPPV-----LLTSLTTAIGFLSLLFSDIppIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKPPELG 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 517 MFTKITGRYVgavgfMVRRGLLGLILMTGMIAATIGLWQNTPGSLVPDedqgyyisaiFLPDGSSLerteqvtQQVVEAV 596
Cdd:COG1033 390 RLLAKLARFV-----LRRPKVILVVALVLAVVSLYGISRLKVEYDFED----------YLPEDSPI-------RQDLDFI 447
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 597 QSNpanenvvaFTGFDfigggyknsaaTLFVTqkhwdereVDTKalvqelfmktagikealvlafnppaifglgntggfe 676
Cdd:COG1033 448 EEN--------FGGSD-----------PLEVV--------VDTG------------------------------------ 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 677 fyiQNKGDSDPDKLQhAMQLMTAEAQKSPIISGLQTLwrpdapqlrVDVDREQARAMGvEIDDAFTALAGNlgtyyvndf 756
Cdd:COG1033 465 ---EPDGLKDPEVLK-EIDRLQDYLESLPEVGKVLSL---------ADLVKELNQALN-EGDPKYYALPES--------- 521
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 757 nkfgrawqvlmsadaefrmkPDDIGRIYVKNNQGTMVPLSAFTTIEYSRGPENLnRYNNLPAVKLMgnaapgyssgQAIA 836
Cdd:COG1033 522 --------------------RELLAQLLLLLSSPPGDDLSRFVDEDYSAARVTV-RLKDLDSEEIK----------ALVE 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 837 EVERIAQAVLPP-NMTYEWTGSAFQEKRSSGTTG----IALGLAVIMVFLILAALYERWSLPLSVMLALpfgTFGALIAV 911
Cdd:COG1033 571 EVRAFLAENFPPdGVEVTLTGSAVLFAAINESVIesqiRSLLLALLLIFLLLLLAFRSLRLGLISLIPN---LLPILLTF 647
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 912 WVVGMTnDVYFQIGLVTL----LGLASKNAILIVEYALMKHQQGWSASTAALEAARLRFRPIIMTSLAFILGVVPLVLSS 987
Cdd:COG1033 648 GLMGLL-GIPLNIATAVVasiaLGIGVDYTIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSS 726
|
730 740 750 760
....*....|....*....|....*....|....*....|.
gi 1675103803 988 GagagarhsVGTGVMGGMMAATFL-----AVFFVPLFFYWL 1023
Cdd:COG1033 727 F--------PPLADFGLLLALGLLvallaALLLLPALLLLL 759
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
302-507 |
4.78e-17 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 86.45 E-value: 4.78e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 302 ALDVAEEVNSVIEEMKSQFPTGL--AHLTSYD--TTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPV 377
Cdd:COG1033 562 SEEIKALVEEVRAFLAENFPPDGveVTLTGSAvlFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLL 641
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 378 SLLGTFAGMYMLGYSINSLTLFGMVLSIGIVVDDAIVVLenvERIMHE--EGLGAREAAVKAMGEVSGPVVAIVLVLCSV 455
Cdd:COG1033 642 PILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFL---SRYREErrKGGDLEEAIRRALRTTGKAILFTSLTLAAG 718
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1675103803 456 FVPIAF--LGGLtgelfRQFAITISIAVSLSGVVALTMTPALCVLILKQEHKQT 507
Cdd:COG1033 719 FGVLLFssFPPL-----ADFGLLLALGLLVALLAALLLLPALLLLLDPRIAKKR 767
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
162-499 |
5.60e-14 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 76.56 E-value: 5.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 162 NVLDRVKRIPGTTSVQIFGAKDYAMrIWLRPD--VMSQLGVTVEEIAGAIrvqnSQYAAGKIGATPTTQSPQELVYSVTA 239
Cdd:pfam00873 691 QILAALAQLPGLSDVRSDGQEDQPQ-LQVNIDreKAARLGVSIQDINDTL----STALGGSYVNDFPEGGRVYDVVVQLP 765
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 240 QGRLSEPEQFENIIIRSNtDGSSLRLKDVARVELGSKDyNFKGTINGKEAVLLGIFLQPGANALDVAEEVNSVIEEMKsq 319
Cdd:pfam00873 766 EDFRSSPEDIGQLYVRNP-YGKMIPLSAFAKIEWGYGP-PSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVK-- 841
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 320 FPTGLAhlTSYDTTRFVEvsiREVVKTLLEAMVLVFLVVYLFL----QNWRATLIPTLAVPVSLLGTFAGMYMLGYSINS 395
Cdd:pfam00873 842 LPPGYG--YTWTGQFEQE---QLAGNSLPILIALALLVVFLVLaalyESWSDPLSIMLTVPLALVGALLALWLRGLPNSV 916
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 396 LTLFGMVLSIGIVVDDAIVVLENVERIMHEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAI 475
Cdd:pfam00873 917 YAQVGLILLIGLAVKNAILMVEFANELREQEGKSLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGI 996
|
330 340
....*....|....*....|....
gi 1675103803 476 TISIAVSLSGVVALTMTPALCVLI 499
Cdd:pfam00873 997 VVFGGLVTSTVLTLLVVPVFYVLF 1020
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
186-499 |
1.02e-12 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 72.74 E-value: 1.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 186 MRIWLRPDVMSQLGVTVEEIAGAIrvqNSQYAAGKIGaTPTTQSPQ-ELVYSVTAQGRLSePEQFENIIIRSNtDGSSLR 264
Cdd:NF033617 704 LNVDIDRDKAARLGISMQDIGSTL---EVAFGQRQVN-TIYTDGNQyKVVLEVDRRYRLN-PEALNQIYVRSN-DGKLVP 777
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 265 LKDVARVEL--GSKDYNFKGTINgkeAVLLGIFLQPGANaldVAEEVNSVIEEMKSQFPTGLAHLTSYDTTRFVEvSIRE 342
Cdd:NF033617 778 LSTLAKIEEraAPLSLNHFNQFN---SATLSFNLAPGVS---LGEAIEALDQAAKELLPSGISGSFQGAARAFQE-EGSS 850
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 343 VVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGMVLSIGIVVDDAIVVLENVERI 422
Cdd:NF033617 851 LLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANEL 930
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1675103803 423 MHEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAVSLSGVVALTMTPALCVLI 499
Cdd:NF033617 931 QRHQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLL 1007
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
163-509 |
2.24e-11 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 68.13 E-value: 2.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 163 VLDRVKRIPGTTSVQIF---GAkdYAMRIWLRPDVMSQLGVTVEEIAGAIRVQnsqyaagkIGATPTTQSPQ-ELVYSVT 238
Cdd:COG3696 694 IEAVLKTVPGAADVQVErvtGL--PQLDIRIDRDAAARYGLNVADVQDVVETA--------IGGKAVGQVYEgERRFDIV 763
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 239 AqgRLSE-----PEQFENIIIRSNtDGSSLRLKDVARVELGSKdYNFKGTINGKEAVLLGIFLQpGANALDVAEEVNSVI 313
Cdd:COG3696 764 V--RLPEelrddPEAIRNLPIPTP-SGAQVPLSQVADIEVVEG-PNQISRENGRRRIVVQANVR-GRDLGSFVAEAQAKV 838
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 314 EEmKSQFPTGlahltsYdttrFVEVS-----IREVVKTLLE----AMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFA 384
Cdd:COG3696 839 AE-QVKLPPG------Y----YIEWGgqfenLQRATARLAIvvplALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVL 907
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 385 GMYMLGY--SINSL----TLFgmvlsiGIVVDDAIVVLENVERIMhEEGLGAREAAVKAMGEVSGPVVAIVLVLCSVFVP 458
Cdd:COG3696 908 ALWLRGMplSVSAGvgfiALF------GVAVLNGVVLVSYINQLR-AEGLDLREAIIEGALERLRPVLMTALVAALGLLP 980
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1675103803 459 IAFLGGLTGELFRQFAItisiaVSLSGVV---ALTM--TPALCVLILKQEHKQTAR 509
Cdd:COG3696 981 MALSTGPGSEVQRPLAT-----VVIGGLItstLLTLlvLPALYLLFGRRRLRRAAA 1031
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
299-499 |
2.83e-10 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 64.40 E-value: 2.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 299 GANALDVAEEVNSVIEEMKSQFPTGL-AHLT--SYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAV 375
Cdd:COG2409 124 GDAGDEAAEAVDALRDAVAAAPAPGLtVYVTgpAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 376 PVSLLGTFAGMYMLGY--SINSLTL-FGMVLSIGIVVDDAIVVlenVERiMHEE---GLGAREAAVKAMGEVSGPVVA-- 447
Cdd:COG2409 204 GLAVGVALGLLALLAAftDVSSFAPnLLTMLGLGVGIDYALFL---VSR-YREElraGEDREEAVARAVATAGRAVLFsg 279
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1675103803 448 ---IVLVLCSVFVPIAFlggltgelFRQFAITISIAVSLSGVVALTMTPALCVLI 499
Cdd:COG2409 280 ltvAIALLGLLLAGLPF--------LRSMGPAAAIGVAVAVLAALTLLPALLALL 326
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
304-499 |
2.00e-09 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 61.78 E-value: 2.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 304 DVAEEVNSVIEEMKsqFPTGL-AHLT-----SYDTTRFVEVSIrevVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPV 377
Cdd:TIGR00921 155 PIYNDVERSLERTN--PPSGKfLDVTgspaiNYDIEREFGKDM---GTTMAISGILVVLVLLLDFKRWWRPLLPLVIILF 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 378 SLLGTFAGMYMLGYSINSLTLFGMVLSIGIVVDDAIVVLENVERIMHeEGLGAREAAVKAMGEvSGPVVAIVLVLCSvfv 457
Cdd:TIGR00921 230 GVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERD-IGRAKGEAIVTAVRR-TGRAVLIALLTTS--- 304
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1675103803 458 pIAFLGGLTGEL--FRQFAITISIAVSLSGVVALTMTPALCVLI 499
Cdd:TIGR00921 305 -AGFAALALSEFpmVSEFGLGLVAGLITAYLLTLLVLPALLQSI 347
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
831-1036 |
3.08e-09 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 61.03 E-value: 3.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 831 SGQAIAEVERIAQAVLPPNMTYEWTGSAFQE----KRSSGTTGIALGLAVIMVFLILAALYERWSLPLSVMLALpfgtfg 906
Cdd:COG1033 179 RKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRgdiaEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVV------ 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 907 aLIAV-WVVGMTNDVYFQIGLVT------LLGLASKNAI-LIVEYaLMKHQQGWSASTAALEAARLRFRPIIMTSLAFIL 978
Cdd:COG1033 253 -LLAViWTLGLMGLLGIPLSPLTilvpplLLAIGIDYGIhLLNRY-REERRKGLDKREALREALRKLGPPVLLTSLTTAI 330
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1675103803 979 GVVPLVLSSgagAGARHSVGTGVMGGMMAATFLAVFFVPLFFYWLTARKLTEKRSRQE 1036
Cdd:COG1033 331 GFLSLLFSD---IPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKP 385
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
335-513 |
2.23e-08 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 57.30 E-value: 2.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 335 FVEVSIREVVKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGY----SINSLTL-FGMVLSIGIVV 409
Cdd:pfam03176 136 LRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILAHilgiGLSTFALnLLVVLLIAVGT 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 410 DDAIVVlenVERImHEE---GLGAREAAVKAMGEVSGPVVAIVLVLCsvfvpIAFLGGLTGEL--FRQFAITISIAVSLS 484
Cdd:pfam03176 216 DYALFL---VSRY-REElraGEDREEAVIRAVRGTGKVVTAAGLTVA-----IAMLALSFARLpvFAQVGPTIAIGVLVD 286
|
170 180 190
....*....|....*....|....*....|..
gi 1675103803 485 GVVALTMTPALCVLI---LKQEHKQTARFFLW 513
Cdd:pfam03176 287 VLAALTLLPALLALLgrwGLWPPKRDRTARWW 318
|
|
| 2A0604s01 |
TIGR00916 |
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY ... |
339-489 |
3.47e-06 |
|
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY proteins form the protein translocation appartus in prokaryotes. This family is specific for the SecD and SecF proteins. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 273336 [Multi-domain] Cd Length: 192 Bit Score: 48.79 E-value: 3.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 339 SIREVVKTLLEAMVLVFLVVYLFLQnWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGMVLSIGIVVDDAIVVLEN 418
Cdd:TIGR00916 45 LIKAGIIALLIGLVLVLLYMLLRYE-WRGAIAAIAALVHDVILILGVLSLFGATLTLPGIAGLLTIIGYSVDDTVVIFDR 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1675103803 419 V-ERIMHEEGLGAREAAVKAmgeVSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAVSLSGVVAL 489
Cdd:TIGR00916 124 IrEELRKYKGRTFREAINLG---INQTLSRIIDTNVTTLLAVLALYVFGGGAIKGFALTLGIGVIAGTYSSI 192
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
302-569 |
3.66e-05 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 48.04 E-value: 3.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 302 ALDVAEEVNSVIEemKSQFPTGL-AHLT-----SYDTTRFVEVSIREVVKTLLEAMVLVFLVVYLFLQNWratLIPTLAV 375
Cdd:TIGR00833 133 AQEAINAVRRIVE--QTNAPDGLtVHVTgplatIADILESGDKDMNRITATTGIIVLIILLLVYRSPITM---LVPLVSV 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 376 PVSLLGTFAGMYMLGY----SINSLTLFGMV-LSIGIVVDDAIVVLENV-ERIMHEEglgAREAAVKAMGEVSGPVVA-- 447
Cdd:TIGR00833 208 GFSVVVAQGIVSLLGIpgliGVNAQTTVLLTaLVIGAGTDYAVFLTGRYhEERRKGE---SLEEAAAEALRGTGKAILgs 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 448 ----IVLVLCSVFVPIaflggltgELFRQFAITISIAVSLSGVVALTMTPALCVL-----ILKQEHKQTARFflwfndMF 518
Cdd:TIGR00833 285 altvAVAFLALSLARL--------PSFKTLGVSCAVGVLVALLNAVTLTPALLTLegregLMKPGRKSKIRF------IW 350
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1675103803 519 TKITGRYVG-AVGFMVRRGLLGLILMTGMIAATIGLWQNTPGSLVPDEDQGY 569
Cdd:TIGR00833 351 RRLGTAVVRrPWPILVTTLIISGVSLLALPLIRTGYDDEKMIPTDLESVQGY 402
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
297-413 |
4.19e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 47.54 E-value: 4.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 297 QPGANALDVAEEVNSVIEEMKSQFptglAHLtsydttrfvevsirevvktLLEAMVLVFLVVYLFLQNWRATLIpTLAVP 376
Cdd:COG4258 618 LPGVRLVDRKAESSSLFGRYRNDA----LWL-------------------LLLALLLILLLLLLRLRSLRRALR-VLLPP 673
|
90 100 110
....*....|....*....|....*....|....*...
gi 1675103803 377 V-SLLGTFAGMYMLGYSINSLTLFGMVLSIGIVVDDAI 413
Cdd:COG4258 674 LlAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYAL 711
|
|
| SecD |
COG0342 |
Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular ... |
339-501 |
4.67e-05 |
|
Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 440111 [Multi-domain] Cd Length: 434 Bit Score: 47.03 E-value: 4.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 339 SIREVVKTLLEAMVLVFLVVYLFLQNWRatLIPTLAVPVSLLGTFAGMYMLGYSinsLTL---FGMVLSIGIVVDDAIVV 415
Cdd:COG0342 269 SIEKGLIAGLIGLLLVALFMLLYYRLPG--LVANIALALNVVLLLGVLSLLGAT---LTLpgiAGIILTIGMAVDANVLI 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 416 LenvERIMHEEGLGAR-EAAV-----KAM-----GEVSGPVVAIVLvlcsvfvpiAFLGglTGELfRQFAITISIAVSLS 484
Cdd:COG0342 344 F---ERIREELRAGRSlRAAIeagfkRAFstildANVTTLIAAVVL---------FVLG--TGPV-KGFAVTLILGILIS 408
|
170
....*....|....*..
gi 1675103803 485 GVVALTMTPALCVLILK 501
Cdd:COG0342 409 MFTAVPVTRPLLNLLLG 425
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
833-1017 |
1.40e-04 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 45.91 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 833 QAIAEVERIAQAVLPPNMTYEWTGSAF----QEKRSSGTTGIALGLAVIMVFLILAALYERWSLPLSVMLALPFGTFGAL 908
Cdd:COG2409 132 EAVDALRDAVAAAPAPGLTVYVTGPAAlaadLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVAL 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 909 IAVWVVGMTNDV-YFQIGLVTLLGLAsknaiLIVEYAL---MKHQQ----GWSASTAALEAARLRFRPIIMTSLAFILGV 980
Cdd:COG2409 212 GLLALLAAFTDVsSFAPNLLTMLGLG-----VGIDYALflvSRYREelraGEDREEAVARAVATAGRAVLFSGLTVAIAL 286
|
170 180 190
....*....|....*....|....*....|....*..
gi 1675103803 981 VPLVLssgAGAGARHSVGTGVMGGMMAATFLAVFFVP 1017
Cdd:COG2409 287 LGLLL---AGLPFLRSMGPAAAIGVAVAVLAALTLLP 320
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
344-495 |
4.79e-04 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 44.27 E-value: 4.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 344 VKTLLEAMVLVFLVVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGMVLSIGIVVDDAIVVLENVERim 423
Cdd:pfam02460 642 IQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVR-- 719
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1675103803 424 hEEGLGAREAAVKAMGEVSGPVV-----AIVLVLCSVFVPiAFLGgltgelfRQFAITISIAVSLSGVVALTMTPAL 495
Cdd:pfam02460 720 -SRGDTPAERVVDALEALGWPVFqgglsTILGVLVLLFVP-SYMV-------VVFFKTVFLVVAIGLLHGLFILPII 787
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
294-599 |
5.20e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 44.07 E-value: 5.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 294 IFLQPGANALD------VAEEVNSVIEEMKSQFPTglAHLTSYDTTRF-VEVSI---REVVKTLLEAMVLVFLVVYLFLQ 363
Cdd:COG4258 194 LLAETRASGFDtdaqqqLVAALRAAFAALNAAFPG--AQLLLTGAGLFaVAAAQqikHDISTIGLISLLGILLLLLLVFR 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 364 NWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTL-FGMVLsIGIVVDDAIVVLenVERiMHEEGLGAREaavkAMGEVS 442
Cdd:COG4258 272 SLRPLLLGLLPVAVGALAGLAAVSLVFGSVHGITLgFGSSL-IGVAVDYSLHYL--THR-RAAGEWDPRA----ALRRIW 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 443 GPVvaIVLVLCSVfvpIAFLG----GLTGelFRQFAITISIAVSLSGVVALTMTPALCVlilKQEHKQTARFFLWFndmf 518
Cdd:COG4258 344 PTL--LLGLLTTV---LGYLAllfsPFPG--LRQLGVFAAAGLLAAALTTLLWLPLLLP---RAAPRPPAPALALL---- 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 519 tkitGRYVGAVGFMVRRGLLGLILMTGMIAAT---------IGLWQNTPGSLVPDEDQgyyISAIF-LPDGSS------- 581
Cdd:COG4258 410 ----ARLLARWPRRLRWLLALLAVLALASLLGlnrlkwnddLRALNPVPAALLAQEAR---LRALLgAPDVSQylvvygp 482
|
330 340
....*....|....*....|...
gi 1675103803 582 -----LERTEQVTQQVVEAVQSN 599
Cdd:COG4258 483 daeqaLQRNEALLPRLDALVAQG 505
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
350-499 |
7.89e-04 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 43.60 E-value: 7.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 350 AMVLVFLVVYLFLqnwRATLIPTLAVPVSLLGTFA-----------GMYMLGYSINSLTLFGMVLSIGIVVD---DAIVV 415
Cdd:COG2409 526 VLGLIFLLLLLLF---RSVVAPLKAVLTNLLSLGAalgvlvlvfqhGWLLLGFTPGPLDSFVPLLLFVILFGlgmDYEVF 602
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 416 LenVERiMHEE---GLGAREAAVKAMGEVSGPVVAIVLVLCSVFVPIAFLGGLTgelFRQFAITISIAVSLSG-VVALTM 491
Cdd:COG2409 603 L--VSR-IREEydrGGGTREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVF---LKQIGFGLAVGVLLDAfVVRMLL 676
|
....*...
gi 1675103803 492 TPALCVLI 499
Cdd:COG2409 677 VPALMALL 684
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
819-1017 |
9.52e-04 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 42.66 E-value: 9.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 819 VKLMGNAApGYSSGQAIAEVERIA-QAVLPPNMTYEWTGSA--FQEKR--SSGTTGIALGLAVIMVFLILAALYERWSLP 893
Cdd:pfam03176 91 VTLEGDPG-TTEADESVAAVRDAVeQAPPPEGLKAYLTGPAatVADLRdaGDRDLGLIEAVTLVVIFIILLIVYRSVVAA 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 894 LSVML--ALPFGTFGALIAVWV-VGMTNDVYFQIGLVTLLGLA--SKNAILIV----EYAlmkhQQGWSASTAALEAARL 964
Cdd:pfam03176 170 LLPLLtvGLSLGAAQGLVAILAhILGIGLSTFALNLLVVLLIAvgTDYALFLVsryrEEL----RAGEDREEAVIRAVRG 245
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1675103803 965 RFRPIIMTSLAFILGVVPLVLSSgagAGARHSVGTGVMGGMMAATFLAVFFVP 1017
Cdd:pfam03176 246 TGKVVTAAGLTVAIAMLALSFAR---LPVFAQVGPTIAIGVLVDVLAALTLLP 295
|
|
| secD |
PRK05812 |
preprotein translocase subunit SecD; Reviewed |
350-505 |
1.22e-03 |
|
preprotein translocase subunit SecD; Reviewed
Pssm-ID: 235615 [Multi-domain] Cd Length: 462 Bit Score: 42.52 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 350 AMVLVFLVVY--LFlqnwraTLIPTLAVPVSLLGTFAGMYMLGYSinsLTL---FGMVLSIGIVVDdaivvlENV---ER 421
Cdd:PRK05812 308 ALVLLFMILYyrLF------GLIANIALVANLVLILAVLSLLGAT---LTLpgiAGIVLTIGMAVD------ANVlifER 372
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 422 IMHE--EGLGAReAAVKA----------MGEVSGPVVAIVLvlcsvFvpiaFLGglTGELfRQFAITISIAVSLSGVVAL 489
Cdd:PRK05812 373 IREElrEGRSLR-SAIEAgfkrafstilDSNITTLIAAIIL-----Y----ALG--TGPV-KGFAVTLGIGILTSMFTAI 439
|
170
....*....|....*.
gi 1675103803 490 TMTPALCVLILKQEHK 505
Cdd:PRK05812 440 TVTRALVNLLYGRRKR 455
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
835-1021 |
3.24e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 41.36 E-value: 3.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 835 IAEVER-IAQAVLPPNMTYEWTGS---AFQEKRSSGTT-GIALGLAVIMVFLILAALYERWSLPLSVMLALPFGTFGALI 909
Cdd:TIGR00921 157 YNDVERsLERTNPPSGKFLDVTGSpaiNYDIEREFGKDmGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLG 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 910 AVWVVGMTNDVYFQIGLVTLLGLASKNAILIVEYALMKHQQGWSASTAALEAARLRFRPIIMTSLAFILGVVPLVLSsga 989
Cdd:TIGR00921 237 IMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALS--- 313
|
170 180 190
....*....|....*....|....*....|..
gi 1675103803 990 GAGARHSVGTGVMGGMMAATFLAVFFVPLFFY 1021
Cdd:TIGR00921 314 EFPMVSEFGLGLVAGLITAYLLTLLVLPALLQ 345
|
|
| ABC_6TM_MsbA_like |
cd18552 |
Six-transmembrane helical domain of the bacterial ABC lipid flippase MsbA and similar proteins; ... |
329-381 |
6.27e-03 |
|
Six-transmembrane helical domain of the bacterial ABC lipid flippase MsbA and similar proteins; The bacterial lipid flippase MsbA is found in Gram-negative bacteria and transports lipid A and lipopolysaccharide (LPS) from the cytoplasmic leaflet to the periplasmic leaflet of the inner membrane. MsbA is also a polyspecific transporter capable of transporting a broad spectrum of drug molecules. Additionally, MsbA exhibits significant sequence similarity to mammalian multidrug resistance (MDR) proteins such as human MDR protein 1 (MDR1) and LmrA from Lactococcus lactis. This subgroup also contains a putative transporter Brevibacillus brevis TycD; the location of the tycD gene within the Tyc (tyrocidine) biosynthesis operon suggests that TycD may play a role in the secretion of the cyclic decapeptide antibiotic tyrocidine. This transmembrane (TM) subunit possesses the ATP-binding cassette (ABC) exporter fold, which is characterized by 6 TM helices per subunit (domain), or a total of 12 TM helices for the complete transporter. The ABC exporters are found in both prokaryotes and eukaryotes, where they mediate the cellular secretion of toxic compounds, a various type of lipids and polypeptides. ABC transporters typically consist of two transmembrane domains (TMDs) and two nucleotide-binding domains (NBDs). The sequences and structures of the TMDs are quite varied between the different type of transporters, suggesting significant structural diversity of the translocated substrates, while NBDs are conserved among all ABC transporters. The two NBDs together bind and hydrolyze ATP, thereby providing the driving force for transport, while the TMDs participate in substrate recognition and translocation across the lipid membrane by alternating between inward- and outward-facing conformations. Moreover, some ABC genes are organized as half-transporters, which must form either homodimers or heterodimers to form a functional transporter. The ABC exporters play a role in multidrug resistance to antibiotics and anticancer agents, and mutations in these proteins have been shown to cause severe human diseases such as cystic fibrosis.
Pssm-ID: 349996 [Multi-domain] Cd Length: 292 Bit Score: 39.71 E-value: 6.27e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1675103803 329 SYDTTRfVEVSIREVVKTLL-EAMVLVFLVVYLFLQNWRATLI-----PTLAVPVSLLG 381
Cdd:cd18552 103 TNDVNQ-VQNALTSALTVLVrDPLTVIGLLGVLFYLDWKLTLIalvvlPLAALPIRRIG 160
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
720-1034 |
6.42e-03 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 40.78 E-value: 6.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 720 QLRVDVDREQARAMGVEIDDAFTALA---GNLGTYYVNDFNKfgrawQVLMSADAEFRmKPDDIGRIYVKNNQGTMVPLS 796
Cdd:COG3696 186 QYQVLVDPAKLRAYGLTLDDVIEALErnnANVGGGYIERGGQ-----EYLVRGIGLIR-SLEDIENIVVKTRNGTPVLLR 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 797 AFTTIEYSRGPenlnRY------NNLPAVKLMGNAAPGYSSGQAIAEV-ERIA--QAVLPPNMTYEwtgsAFQE-----K 862
Cdd:COG3696 260 DVAEVRIGPAP----RRgaatlnGEGEVVGGIVLMLKGENALEVIEAVkAKLAelKPSLPEGVKIV----PFYDrsdliD 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 863 RSSGTTGIALGLAVIMVFLILAALYERWSLPLSVMLALPFGTFGALIAVWVVGMTndvyfqIGLVTLLGLA------SKN 936
Cdd:COG3696 332 RAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGIS------ANLMSLGGLAidfgiiVDG 405
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 937 AILIVEyALMKHQQGWSASTAALEAARLRF-------RPIIMTSLAFILGVVPL-VLssgagagarhsvgTGVMGGM--- 1005
Cdd:COG3696 406 AVVMVE-NILRRLEENRAAGTPRERLEVVLeaarevrRPIFFATLIIILVFLPIfTL-------------EGVEGKLfrp 471
|
330 340 350
....*....|....*....|....*....|....*...
gi 1675103803 1006 MAATF---------LAVFFVPLFFYWLTARKLTEKRSR 1034
Cdd:COG3696 472 MALTVifallgallLSLTLVPVLASLLLRGKVPEKENP 509
|
|
| secD |
TIGR01129 |
protein-export membrane protein SecD; Members of this family are highly variable in length ... |
339-495 |
7.65e-03 |
|
protein-export membrane protein SecD; Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 273456 [Multi-domain] Cd Length: 397 Bit Score: 39.96 E-value: 7.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1675103803 339 SIREVVKTLLEAMVLVFlvVYLFLQNWRATLIPTLAVPVSLLGTFAGMYMLGYSINSLTLFGMVLSIGIVVDDAIVVLen 418
Cdd:TIGR01129 246 SIEAGIKAGLIGLVLVL--VFMILYYRLFGLIAAIALVINIVLILAILSAFGATLTLPGIAGLILTIGMAVDANVLIY-- 321
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1675103803 419 vERIMHEEGLGarEAAVKAMGE-VSGPVVAIVLVLCSVFVPIAFLGGLTGELFRQFAITISIAVSLSGVVALTMTPAL 495
Cdd:TIGR01129 322 -ERIKEELRLG--KSVRQAIEAgFERAFSTIFDANITTLIAALILYVFGTGPVKGFAVTLAIGIIASLFTALVFTRLL 396
|
|
| |
