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Conserved domains on  [gi|1692740057|ref|WP_139875278|]
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4-hydroxybenzoate octaprenyltransferase [Candidatus Methylopumilus universalis]

Protein Classification

UbiA prenyltransferase family protein( domain architecture ID 91)

UbiA prenyltransferase family protein, an aromatic prenyltransferase, plays an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PT_UbiA super family cl00337
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 4-279 4.74e-93

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


The actual alignment was detected with superfamily member TIGR01474:

Pssm-ID: 469727  Cd Length: 281  Bit Score: 276.51  E-value: 4.74e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   4 YLRLMRLDKPIGIFLLLWPTLWALFIA--SHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQS 81
Cdd:TIGR01474   4 YAKLMRADKPIGTLLLLWPCLWSLLLAaqAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLASGA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  82 IPVKNAFFLLITLLLGALICVLFLNKNAFYFSLVALFLALTYPLTKRFFVMPQAYLGLSFGMGIPIAFVANDISLSITTW 161
Cdd:TIGR01474  84 VSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLSTAAW 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 162 PLFLANVFWAIAYDTLYAVTDKNDDLKIGIRSSAIWFGAYVKEAIMFCYTCMMGCLIWVGQLENFGWPFYGFIGLSLIfi 241
Cdd:TIGR01474 164 VLYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAAAL-- 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1692740057 242 gLLYRQILTL---NPKACFDAFLSNNYLGAFVFLGIFFHYL 279
Cdd:TIGR01474 242 -LLIRQIATLdirDPENCLKLFKANNYVGLLLFAGIALGWL 281
 
Name Accession Description Interval E-value
ubiA_proteo TIGR01474
4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of ...
 4-279 4.74e-93

4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 130539  Cd Length: 281  Bit Score: 276.51  E-value: 4.74e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   4 YLRLMRLDKPIGIFLLLWPTLWALFIA--SHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQS 81
Cdd:TIGR01474   4 YAKLMRADKPIGTLLLLWPCLWSLLLAaqAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLASGA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  82 IPVKNAFFLLITLLLGALICVLFLNKNAFYFSLVALFLALTYPLTKRFFVMPQAYLGLSFGMGIPIAFVANDISLSITTW 161
Cdd:TIGR01474  84 VSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLSTAAW 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 162 PLFLANVFWAIAYDTLYAVTDKNDDLKIGIRSSAIWFGAYVKEAIMFCYTCMMGCLIWVGQLENFGWPFYGFIGLSLIfi 241
Cdd:TIGR01474 164 VLYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAAAL-- 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1692740057 242 gLLYRQILTL---NPKACFDAFLSNNYLGAFVFLGIFFHYL 279
Cdd:TIGR01474 242 -LLIRQIATLdirDPENCLKLFKANNYVGLLLFAGIALGWL 281
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 8-276 2.45e-90

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 268.95  E-value: 2.45e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   8 MRLDKPIGIFLLLWPTLWALFIASHGNPS--IQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIPVK 85
Cdd:cd13959     1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLplLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  86 NAFFLLITLLLGALICVLFLNKNAFYFSLVALFLALTYPLTKRFFVMPQAYLGLSFGMGIPIAFVANDISLSITTWPLFL 165
Cdd:cd13959    81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSLPLPALLLYL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 166 ANVFWAIAYDTLYAVTDKNDDLKIGIRSSAIWFGAYVKEAIMFCYTCMMGCLIWVGQLENFGWPFYGFIGLSLIFIGLLY 245
Cdd:cd13959   161 AVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLFVALLLLAGGLAGLGWPYYLGLGAAAHLLWQEH 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1692740057 246 RQILTLNPKACFDAFLSNNYLGAFVFLGIFF 276
Cdd:cd13959   241 RLDLPDPLRSCLAFFLSNGWVGLLLFAGLLL 271
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 4-276 4.26e-68

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 212.78  E-value: 4.26e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   4 YLRLMRLDKPIGIFLLLWPTLWALFIASHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIP 83
Cdd:COG0382     3 YLRLLRLDRPIGILLLLWPTLWALFLAAGGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLASGRIS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  84 VKNAFFLLITLLLGALICVLFLNKNAFYFSLVALFLALTYPL-TKRFFVMPQAYLGLSFGMGIPIAFVANDISLSITTWP 162
Cdd:COG0382    83 LREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLfLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPLSAWL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 163 LFLANVFWAIAYDTLYAVTDKNDDLKIGIRSSAIWFGAYVKEAIM-FCYTCMMGCLIWVGQLENFGWPFYGFIGLSLIFI 241
Cdd:COG0382   163 LALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAgVLYALAVLLLLLLGLLAGLGLLYLLGLLAALLLL 242

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1692740057 242 gLLYRQIL----TLNPKACFDAFLSNNYLGAFVFLGIFF 276
Cdd:COG0382   243 -YLSQLWLlrprKKDPARALKLFKLNMLLGLLLFLGIAL 280
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 4-276 2.93e-61

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 195.30  E-value: 2.93e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   4 YLRLMRLDKPIGIFLLLWPTLWALFIA-SHGN-PSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQS 81
Cdd:PLN02809    9 YAKLARLDKPIGTWLLAWPCMWSIALAaPPGSlPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLRPIASGA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  82 IPVKNAFFLLITLLLGALICVLFLNKNAFYFSLVALFLALTYPLTKRFFVMPQAYLGLSFGMGIPIAFVANDISLS-ITT 160
Cdd:PLN02809   89 LTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVKGSLDpAVV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 161 WPLFLANVFWAIAYDTLYAVTDKNDDLKIGIRSSAIWFGAYVKEAIMFCYTCMMGCLIWVGQLENFGWPFYGFIGLSlif 240
Cdd:PLN02809  169 LPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYAGLAAA--- 245

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1692740057 241 IGLLYRQILTLN---PKACFDAFLSNNYLGAFVFLGIFF 276
Cdd:PLN02809  246 AGHLAWQIQTVDlssRADCNRKFVSNKWFGAIVFAGIVL 284
UbiA pfam01040
UbiA prenyltransferase family;
19-261 6.72e-38

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 133.89  E-value: 6.72e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  19 LLWPTLWALFIASHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIPVKNAFFLLITLLLGA 98
Cdd:pfam01040   1 LLIPALAGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  99 LICVLFLNKNAFYFSLVALFLALTYPL-TKRFFVMPQAYLGLSFGMGIPIAFVANDISLSITTWPLFLANVFWAIAYDTL 177
Cdd:pfam01040  81 LLLLLLLNPLTALLGLAALLLYVLYTLrLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAIALA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 178 YAVTDKNDDLKIGIRSSAIWFGAYVKEAIMFCYTCMMGCLIWVGQLENFGWPFYGF-IGLSLIFIGLLYRQILTLNPKAC 256
Cdd:pfam01040 161 NDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLGGLYLLLaLLLAALALLYAARLLRLRDPKKD 240


                  ....*
gi 1692740057 257 FDAFL 261
Cdd:pfam01040 241 AKAFF 245
 
Name Accession Description Interval E-value
ubiA_proteo TIGR01474
4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of ...
 4-279 4.74e-93

4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 130539  Cd Length: 281  Bit Score: 276.51  E-value: 4.74e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   4 YLRLMRLDKPIGIFLLLWPTLWALFIA--SHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQS 81
Cdd:TIGR01474   4 YAKLMRADKPIGTLLLLWPCLWSLLLAaqAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLASGA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  82 IPVKNAFFLLITLLLGALICVLFLNKNAFYFSLVALFLALTYPLTKRFFVMPQAYLGLSFGMGIPIAFVANDISLSITTW 161
Cdd:TIGR01474  84 VSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLSTAAW 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 162 PLFLANVFWAIAYDTLYAVTDKNDDLKIGIRSSAIWFGAYVKEAIMFCYTCMMGCLIWVGQLENFGWPFYGFIGLSLIfi 241
Cdd:TIGR01474 164 VLYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAAAL-- 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1692740057 242 gLLYRQILTL---NPKACFDAFLSNNYLGAFVFLGIFFHYL 279
Cdd:TIGR01474 242 -LLIRQIATLdirDPENCLKLFKANNYVGLLLFAGIALGWL 281
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 8-276 2.45e-90

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 268.95  E-value: 2.45e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   8 MRLDKPIGIFLLLWPTLWALFIASHGNPS--IQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIPVK 85
Cdd:cd13959     1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLplLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  86 NAFFLLITLLLGALICVLFLNKNAFYFSLVALFLALTYPLTKRFFVMPQAYLGLSFGMGIPIAFVANDISLSITTWPLFL 165
Cdd:cd13959    81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSLPLPALLLYL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 166 ANVFWAIAYDTLYAVTDKNDDLKIGIRSSAIWFGAYVKEAIMFCYTCMMGCLIWVGQLENFGWPFYGFIGLSLIFIGLLY 245
Cdd:cd13959   161 AVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLFVALLLLAGGLAGLGWPYYLGLGAAAHLLWQEH 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1692740057 246 RQILTLNPKACFDAFLSNNYLGAFVFLGIFF 276
Cdd:cd13959   241 RLDLPDPLRSCLAFFLSNGWVGLLLFAGLLL 271
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 4-276 4.26e-68

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 212.78  E-value: 4.26e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   4 YLRLMRLDKPIGIFLLLWPTLWALFIASHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIP 83
Cdd:COG0382     3 YLRLLRLDRPIGILLLLWPTLWALFLAAGGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLASGRIS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  84 VKNAFFLLITLLLGALICVLFLNKNAFYFSLVALFLALTYPL-TKRFFVMPQAYLGLSFGMGIPIAFVANDISLSITTWP 162
Cdd:COG0382    83 LREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLfLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPLSAWL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 163 LFLANVFWAIAYDTLYAVTDKNDDLKIGIRSSAIWFGAYVKEAIM-FCYTCMMGCLIWVGQLENFGWPFYGFIGLSLIFI 241
Cdd:COG0382   163 LALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAgVLYALAVLLLLLLGLLAGLGLLYLLGLLAALLLL 242

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1692740057 242 gLLYRQIL----TLNPKACFDAFLSNNYLGAFVFLGIFF 276
Cdd:COG0382   243 -YLSQLWLlrprKKDPARALKLFKLNMLLGLLLFLGIAL 280
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 4-276 2.93e-61

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 195.30  E-value: 2.93e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   4 YLRLMRLDKPIGIFLLLWPTLWALFIA-SHGN-PSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQS 81
Cdd:PLN02809    9 YAKLARLDKPIGTWLLAWPCMWSIALAaPPGSlPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLRPIASGA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  82 IPVKNAFFLLITLLLGALICVLFLNKNAFYFSLVALFLALTYPLTKRFFVMPQAYLGLSFGMGIPIAFVANDISLS-ITT 160
Cdd:PLN02809   89 LTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVKGSLDpAVV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 161 WPLFLANVFWAIAYDTLYAVTDKNDDLKIGIRSSAIWFGAYVKEAIMFCYTCMMGCLIWVGQLENFGWPFYGFIGLSlif 240
Cdd:PLN02809  169 LPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYAGLAAA--- 245

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1692740057 241 IGLLYRQILTLN---PKACFDAFLSNNYLGAFVFLGIFF 276
Cdd:PLN02809  246 AGHLAWQIQTVDlssRADCNRKFVSNKWFGAIVFAGIVL 284
ubiA PRK12873
4-hydroxybenzoate polyprenyltransferase;
4-254 3.51e-46

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 171787 [Multi-domain]  Cd Length: 294  Bit Score: 156.75  E-value: 3.51e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   4 YLRLMRLDKPIGIFLLLWPTLWALFIASHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIP 83
Cdd:PRK12873   10 WFELLRWNKPTGRLILLIPAGWSLWLTPSAPPSLLLLLLIILGGLAVSGAGCIANDLWDRRIDRKVERTKNRPLARGKIS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  84 VKNAFFLLITLLLGALICVLFLNKNAFYFSLVALFLA----LTYPLTKRFFVMPQAYLGLSFGMGIPIAFVANDISLSIt 159
Cdd:PRK12873   90 LKTAYSLLIVLLLLSLFVVLSLPQPSRNLCLSLAFLAlppiLIYPSAKRWFAYPQAILALCWGFAVLIPWAAAEGSLNG- 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 160 TWPL---FLANVFWAIAYDTLYAVTDKNDDLKIGIRSSAIWFGAYVKEAIMFCYTCMMGCLIWVGQLENFGWPFYGFIGL 236
Cdd:PRK12873  169 GWPLlfcWLATLLWTFGFDTVYAMADRRDDAKIGLNSSALSLGSNALKTVQICYFLTSIFLALAAFIAQVGFIFWPFWLI 248

                         250
                  ....*....|....*...
gi 1692740057 237 SLIfigLLYRQILTLNPK 254
Cdd:PRK12873  249 ASI---GMQRDILKLFPE 263
UbiA pfam01040
UbiA prenyltransferase family;
19-261 6.72e-38

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 133.89  E-value: 6.72e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  19 LLWPTLWALFIASHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIPVKNAFFLLITLLLGA 98
Cdd:pfam01040   1 LLIPALAGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  99 LICVLFLNKNAFYFSLVALFLALTYPL-TKRFFVMPQAYLGLSFGMGIPIAFVANDISLSITTWPLFLANVFWAIAYDTL 177
Cdd:pfam01040  81 LLLLLLLNPLTALLGLAALLLYVLYTLrLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAIALA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 178 YAVTDKNDDLKIGIRSSAIWFGAYVKEAIMFCYTCMMGCLIWVGQLENFGWPFYGF-IGLSLIFIGLLYRQILTLNPKAC 256
Cdd:pfam01040 161 NDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALLLLLLLLLLLLGGLYLLLaLLLAALALLYAARLLRLRDPKKD 240


                  ....*
gi 1692740057 257 FDAFL 261
Cdd:pfam01040 241 AKAFF 245
ubiA_other TIGR01475
putative 4-hydroxybenzoate polyprenyltransferase; A fairly deep split separates this ...
 28-279 3.97e-20

putative 4-hydroxybenzoate polyprenyltransferase; A fairly deep split separates this polyprenyltransferase subfamily from the set of mitochondrial and proteobacterial 4-hydroxybenzoate polyprenyltransferases, described in TIGR01474. Protoheme IX farnesyltransferase (heme O synthase) (TIGR01473) is more distantly related. Because no species appears to have both this protein and a member of TIGR01474, it is likely that this model represents 4-hydroxybenzoate polyprenyltransferase, a critical enzyme of ubiquinone biosynthesis, in the Archaea, Gram-positive bacteria, Aquifex aeolicus, the Chlamydias, etc. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273646  Cd Length: 282  Bit Score: 87.40  E-value: 3.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  28 FIASHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIPVKNAFFLLITLLLGALICVLFLNK 107
Cdd:TIGR01475  26 LLAAKGLPGLKTLILILIAAVSARTAAMAFNRIIDRAIDARNPRTKNRPLVSGLISKKEARTMIILSLALFLSASYFLNP 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 108 NAFYFSLVALFLALTYPLTKRFFVMPQAYLGLSFGMGIPIAFVA--NDISLSITTWPLFLANVFWAIAYDTLYAVTDKND 185
Cdd:TIGR01475 106 LAFILSPLVLLVLIIYPYTKRFTFLCHYVLGSTYGLAPLAGWVAviGTISFFLVAWLLGIGVGFWIAGFDLIYAIQDYEF 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 186 DLKIGIRSSAIWFGayVKEAIMF---CYTCMMGCLIWVGQLENFGWPFYGFIGLSLIFIGLLYRQILTLNPKACFDA-FL 261
Cdd:TIGR01475 186 DRKNGLHSIPARFG--IKAALKIaslSHVITFILLLLVGFYVGNGYIALLALILIGLILAYEHYIVDPGDQSKIQRAfFY 263

                         250
                  ....*....|....*...
gi 1692740057 262 SNNYLGAFVFLGIFFHYL 279
Cdd:TIGR01475 264 ANGFLSITFLIGVIIDVL 281
ubiA PRK12888
4-hydroxybenzoate octaprenyltransferase;
24-249 3.29e-17

4-hydroxybenzoate octaprenyltransferase;


Pssm-ID: 183814  Cd Length: 284  Bit Score: 79.38  E-value: 3.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  24 LWALFIAShGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIPVKNAFFLLITLLLGALICVL 103
Cdd:PRK12888   26 LTAMFASD-GSVHWADLLLVTVAMVGARTFAMAANRIIDREIDARNPRTAGRELVTGAVSVRTAWTGALVALAVFLGAAA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 104 FLNKNAFYFSLVALFLALTYPLTKRFFVMPQAYLGLSFGMGIPIAFVANDISLSITTWPLFLANVFWAIAYDTLYAVTDK 183
Cdd:PRK12888  105 LLNPLCLALAPLAVAPLVVYPYAKRFTNFPHAILGLAQAVGPVGAWIAVTGTWSWPAVLLGLAVGLWIGGFDLIYACQDA 184

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1692740057 184 NDDLKIGIRSSAIWFGAYVK-EAIMFCYTCMMGCLIWVGQLENFGWPFYgfIGLSLIFIGLLYRQIL 249
Cdd:PRK12888  185 EVDRRIGVRSVPARFGVRAAlWASRVAHVVTFALFVWFGLAVGFGALWW--IGLAITAGAFAYEHAI 249
ubiA PRK13106
prenyltransferase; Reviewed
 4-274 6.45e-17

prenyltransferase; Reviewed


Pssm-ID: 237283  Cd Length: 300  Bit Score: 79.00  E-value: 6.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   4 YLRLMRLDKPIgiFLLLWPTLWAlFIASHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIP 83
Cdd:PRK13106   18 ILRFLRIEQTF--FSLPMAYLGA-FVAIKGIPPISTLILIFLALFFLRTAGMTNDNLADLEIDAKNPRTKNRPLVTGAIK 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  84 VKNAFFLLITLLLGALICVLFLNKNAFYFSLVALFLALTYPLTKRFFVMPQAYLGLSFG---MGIPIAFVANDISLSITT 160
Cdd:PRK13106   95 ISEAKALITAGLILFFASAYLVNRWALLLSPIVALIAMSYPYMKRYTAFANYHLASIQGlavFSGAVAVLGLYANSLIQV 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 161 -----WPLFLANVFWAIAYDTLYAVTDKNDDLKIGIRSSAIWFG--AYVKEAIMFCYTCMMgcLIWVGQLENFGWPFYgf 233
Cdd:PRK13106  175 llrvpWLFVIGTILWAAGFDLYNHIPDAEFDREMGLHSFAVVLGkwALTFAGLNQLFSVVL--DLLGDLYYGLGPIAI-- 250

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1692740057 234 IGLSLIFIGLLYRQILTLNPKACFDAFLSNNYLGAFVFLGI 274
Cdd:PRK13106  251 AATILHGLIMAYAYYLASKKGDFGRAFYYNIYSSIVLGLGI 291
ubiA PRK12886
prenyltransferase; Reviewed
 29-276 5.71e-13

prenyltransferase; Reviewed


Pssm-ID: 237247  Cd Length: 291  Bit Score: 67.41  E-value: 5.71e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  29 IASHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIPVKNAFFLLITLLLGALICVLFLNKN 108
Cdd:PRK12886   33 LAALGLPGASQLDWILMAMVGARTAAMGFNRLIDAEIDARNPRTAGRAIPAGLISKGSAILFIVLSSLLMLFAAWFLNPL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 109 AFYFSLVALFLALTYPLTKRFFVMPQAYLGLSFGMGIPIAFVANDISLSITTWPLFLANVFWAIAYDTLYAVTDKNDDLK 188
Cdd:PRK12886  113 CLYLSPPALFFLLLYSYCKRFTALAHVVLGFCLALAPLGAWIAIRGTIELPAILLGLAVLFWVAGFDILYALQDLEFDRK 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 189 IGIRSSAIWFG--AYVKEAIMFcYTCMMGCLIWVGQLENFGwpFYGFIGLSLIFIGLLYR-QILTLNPKACFDA--FLSN 263
Cdd:PRK12886  193 EGLHSIPAKLGvnGSLWIARVF-HLLMIGFLFALGISAGLG--PWFLAGLAVTGILLLYEhWLLRGGDLTRLDAafFNMN 269

                         250
                  ....*....|...
gi 1692740057 264 NYLGAFVFLGIFF 276
Cdd:PRK12886  270 GYISVTLFAATLF 282
ubiA PRK12874
4-hydroxybenzoate polyprenyltransferase;
43-275 3.45e-12

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 237242  Cd Length: 291  Bit Score: 65.41  E-value: 3.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  43 FILGTVLMRSAGCVA---NDILDRKFDFHVARTKLRPLANQSIPVKNAFFLLITLLLGALICVLFLNKNAFYFSLVALFL 119
Cdd:PRK12874   49 LILGILAAVSARNFAmafNRLVDRDIDKDNPRTANRPSVDGRISVKSMVLFIVLNALIFIGVSYFINPLAFKLSFPFLIV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 120 ALTYPLTKRFFVMPQAYLGLSFGMGiPIAFVANdISLSITTWPLFLA--NVFWAIAYDTLYAVTDKNDDLKIGIRSSAIW 197
Cdd:PRK12874  129 LGGYSYFKRFSSLAHLVLGLSLGLA-PIAGVVA-VLGEIPLWSVFLAlgVMFWVAGFDLLYSLQDMEFDKKRGLHSIPSK 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 198 FGayVKEAIMFCYTCMM------GCLIWVGQLENFGWPFYGFIGLSLIFIGLLYRQILTLNPKACFDaflSNNYLGAFVF 271
Cdd:PRK12874  207 FG--EKATLFISRLFHLlavlfwLLFVWCAHLGLFAYLGVIVSALILLYEHYLVRKDFKKIDKAFFT---LNGYLGIVFF 281


                  ....
gi 1692740057 272 LGIF 275
Cdd:PRK12874  282 IFIV 285
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 3-281 6.73e-10

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 439879  Cd Length: 299  Bit Score: 58.61  E-value: 6.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   3 HYLRLMrldKPIGIFLLLWPTLWALFIASHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSI 82
Cdd:COG0109    18 DYLALT---KPRIILLLLFTALAGMLLAAGGLPDLLLLLLTLLGGALAAGAANALNNYIDRDIDALMKRTKNRPLPTGRI 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  83 PVKNAF-FLLITLLLGALICVLFLNKNAFYFSLVALFL-ALTY-PLTKRffVMPQAYL--GLSFGMGIPIAFVANDISLS 157
Cdd:COG0109    95 SPREALiFGLVLGVLGLALLALFVNPLAALLGLLGIFFyVVVYtLWLKR--RTPQNIVigGAAGAMPPLIGWAAVTGSLS 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 158 ITTWPLFLANVFW--------AIAYDTLYA--------VTDknddlkiGIRSSAIWFGAYVkeAIMFCYTCMMGCLIWVG 221
Cdd:COG0109   173 LEALLLFLIIFLWtpphfwalALKRRDDYAragvpmlpVVK-------GERRTKRQILLYT--LLLVPVSLLPYLLGMAG 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1692740057 222 qlenfgwPFYGFI--GLSLIFIGLLYRQILTLNPKACFDAFL-SNNYLGAFVFLGIFFHYLHV 281
Cdd:COG0109   244 -------LIYLVValVLGAWFLYLAVRLYRRPDRKWARKLFKfSILYLTLLFLALLVDHLLLL 299
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 8-272 3.51e-09

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 56.29  E-value: 3.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   8 MRLDKPIGIFLLLWPTLWALFIASHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIPVKNA 87
Cdd:cd13957     1 LELTKPRITLLVLLTALAGYLLAPGGVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKHA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  88 F-FLLITLLLGALICVLFLNKNAFYFSLVALFL-ALTY-PLTKRFfvMPQAYLGLSFGMGIP--IAFVANDISLSITTWP 162
Cdd:cd13957    81 LiFGLVLGILGLALLALFVNPLTALLGLLGIFLyVFVYtPLKKRT--TPLNTVIGGIAGAIPplIGWAAATGSLDLGAWL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 163 LFLANV------FWAIAYdtLYavtdKNDDLKIGIRSSAIWFGAYVKEAIMFCYT-CMMGCLIWVGQLENFGWPF-YGFI 234
Cdd:cd13957   159 LFLILFlwqpphFWALAI--LY----RDDYARAGIPMLPVVKGERRTKRQILLYTlLLVPLSLLLYLLGLTGWIYlVVAL 232

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1692740057 235 GLSLIFIGLLYRQILTLNPKACFDAFL-SNNYLGAFVFL 272
Cdd:cd13957   233 LLGLYFLYLAIKLYRSPDDKWARKLFFaSLIYLPLLFLL 271
ubiA PRK12876
prenyltransferase; Reviewed
 41-218 1.45e-08

prenyltransferase; Reviewed


Pssm-ID: 237244  Cd Length: 300  Bit Score: 54.75  E-value: 1.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  41 TIFILGT--VLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIPVKNAFFLLITLLLGALICVLFLNKNAFYFSLVALF 118
Cdd:PRK12876   48 TISLGGSafFCARTVGIIVNQIIDCAIDKKNPRTSSRVLPAKLLSINFSMLLLTLCSFLFLSLCWLLNPLCFSLAVLSTL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 119 LALTYPLTKRFFVMPQAYLGLSFGMGIPIAFVAndISLSITTWPLFLANVFWAI-------AYDTLYAVTDKNDDLKIGI 191
Cdd:PRK12876  128 LMIIYPYTKRVTFLCHWILGLVYYLAILMNFFA--IIETPLSFSLFCMASLWGIsfgmiiaANDIIYAIQDLEFDRKEGL 205

                         170       180
                  ....*....|....*....|....*..
gi 1692740057 192 RSSAIWFGayVKEAIMFCYTCMMGCLI 218
Cdd:PRK12876  206 FSIPARFG--EKKAIRIASANLIASAI 230
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 5-221 2.51e-07

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 50.81  E-value: 2.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   5 LRLMRLdkPIGIFLLLWPTLWALFIASHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTklRPLANQSIPV 84
Cdd:cd13956     1 LRLMRP--YTLLYVLAPALAGAALAGAFAGPLPALLLLALLAVFLGAGAGYALNDYTDRELDAINKPD--RPLPSGRLSP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  85 KNAFFLLITLLLGALICVLFLNKNAFYFSLVALFLALTYPLTKRFFVMPQ-AYLGLSFGMG-IPIAFVANDISLSITTWP 162
Cdd:cd13956    77 RQALAFAAALLLVGLALALALGPLALLLLLAGLLLGLAYSLGLKRLKLGGwGVLGYATGLAlLPGLGAVAAGGLVPLALL 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1692740057 163 LFLANVFWAIAYDTLYAVTDKNDDLKIGIRSSAIWFGayVKEAIMFCYTCMMGCLIWVG 221
Cdd:cd13956   157 LALVFLLLGLGINLYNDLPDVEGDRAAGIRTLPVRLG--PRRARRLAAGLLLAALILVV 213
ubiA PRK12895
prenyltransferase; Reviewed
 37-199 4.18e-07

prenyltransferase; Reviewed


Pssm-ID: 237251  Cd Length: 286  Bit Score: 50.20  E-value: 4.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057  37 IQHLTIFILGtVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIPVKNAFFLLITLLLGALICVLFLNKNAFYFSLVA 116
Cdd:PRK12895   37 IKILLILIAA-VSARTSAMSINRIEGLRYDMINPRKKDWALVSGRIKMREAIAFTIIFIAIFEICTFLLNRLVFILSPIV 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 117 LFLALTYPLTKRFFVMPQAYLGLSFGMGIPIAFVA--NDISLSITTWPLFLANVFWAIAYDTLYAVTDKNDDLKIGIRSS 194
Cdd:PRK12895  116 IFLFIIDPFLKRYTAWRHIYMGSIIGLGVLAGYLAviPAFPYNLLIYIIFISSSLWIAGFDIIYVIPDIEYDKINGLKTI 195


                  ....*
gi 1692740057 195 AIWFG 199
Cdd:PRK12895  196 MNTYG 200
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 4-88 9.19e-07

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 48.98  E-value: 9.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057   4 YLRLMrldKPIGIFLLLWPTLWALFIASHGNPSIQHLTIFILGTVLMRSAGCVANDILDRKFDFHVARTKLRPLANQSIP 83
Cdd:PRK04375   13 YLALT---KPRVISLNLFTALGGMLLAPPGVPPLLLLLLTLLGIALVAGAAGALNNYIDRDIDAKMERTKNRPLVTGRIS 89


                  ....*
gi 1692740057  84 VKNAF 88
Cdd:PRK04375   90 PREAL 94
PT_UbiA_4 cd13966
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 145-278 6.20e-04

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260129  Cd Length: 272  Bit Score: 40.32  E-value: 6.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1692740057 145 IPIAFVANDISLSITTWPLFLANVFWAIAYDTLYAVTDKNDDLKIGIRSSAIWFGAyvKEAIMFCYTCMMGCLIWVGqLE 224
Cdd:cd13966   143 LPPALVGLLASGTLPPWLALAAFFLWGMAMHAFGAIQDIEADREAGIRTTATVLGA--RGTLRLALALWLLAAVLVL-PL 219

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1692740057 225 NFGWPFyGFIGLSLIFIGLLYRQILTLNPKACFDAFLSNNYLGAFVFLGIFFHY 278
Cdd:cd13966   220 SLPLPL-SYLALVYPAISLADALAGRTNPRGYWRFPWINTVVGFVLTVLLIWRA 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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