|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
156-462 |
4.35e-94 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 289.92 E-value: 4.35e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 156 DLIYDMGLILAPLALAITLLTIWIGRKIIIAITRPLSQMERVANHLATGDFSERITISSEDEIGRLGKAFNKMANSLETE 235
Cdd:COG5002 74 LLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVER 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 236 DVK--------RKEFLANVSHELRTPLSYIKGYSEAILDGVAKGP-QQEKVTQLIHKEADRMQRLVHDLLDLAQLEGEHF 306
Cdd:COG5002 154 DITelerleqmRREFVANVSHELRTPLTSIRGYLELLLDGAADDPeERREYLEIILEEAERLSRLVNDLLDLSRLESGEL 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 307 PLKKQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLNPE-IIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDY 385
Cdd:COG5002 234 KLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDpLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQ 313
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1695318305 386 CELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQDE 462
Cdd:COG5002 314 VRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
224-462 |
8.54e-79 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 244.82 E-value: 8.54e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 224 AFNKMANSLETEDVKRKEFLANVSHELRTPLSYIKGYSEAILDGVAKGP-QQEKVTQLIHKEADRMQRLVHDLLDLAQLE 302
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPeERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 303 GEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLNPE-IIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQ 381
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 382 IDDYCELNIKDTGIGIDIEHLENLGERFYRVDkaRSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQD 461
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
.
gi 1695318305 462 E 462
Cdd:COG2205 239 S 239
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
106-457 |
1.22e-78 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 255.83 E-value: 1.22e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 106 RQALLDGKTVTKIGYEEHFDRNIMGVVIPVL-ENKKLVGIVYSYIPLKSIKDLIYDMGLILAP---LALAIT-LLTIWIG 180
Cdd:NF033092 119 KRALLGGKDNEKILIDPEDNNRVYVLATPIKsSNGEVVGAIYIEASMESVYDQMNNINLIFATgtlIALVITaVLGILLA 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 181 RkiiiAITRPLSQMERVANHLATGDFSERITISSEDEIGRLGKAFNKMANSLE--------------------------- 233
Cdd:NF033092 199 R----TITRPIKEMRKQALAMAKGDFSRKVKVYGNDEIGQLAEAFNNLTKRLQeaqatteserrkldsvlshmtdgviat 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 --------------------------------------------------------------------------------
Cdd:NF033092 275 drrgrvilindpalemlnvsretvlgqsildvlgleeeytlrdlleeqdsllldfsteeeplilranfsviqresgfing 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 234 --------TE----DVKRKEFLANVSHELRTPLSYIKGYSEAILDGVAK----GPQQEKVTQlihKEADRMQRLVHDLLD 297
Cdd:NF033092 355 liavlhdvTEqekiEQERREFVANVSHELRTPLTTMRSYLEALADGAWKdpelAPRFLGVTQ---NETERMIRLVNDLLQ 431
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 298 LAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLNPE-IIVMIDEDRMQQVLHNVLDNAIRYTNQNGDII 376
Cdd:NF033092 432 LSRMDSKDYKLNKEWVNFNEFFNYIIDRFEMILKNKNITFKREFPKRdLWVEIDTDKITQVLDNIISNAIKYSPEGGTIT 511
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 377 ITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIK 456
Cdd:NF033092 512 FRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFT 591
|
.
gi 1695318305 457 L 457
Cdd:NF033092 592 L 592
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
157-460 |
2.35e-77 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 244.43 E-value: 2.35e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 157 LIYDMGLILAPLALAITLLTIWIGRKIIIAITRPLSQMERVANHLATGDFSERITISSEDEIGRLGKAFNKMANSLETED 236
Cdd:COG0642 28 LLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEAN 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 237 VKRKEFLANVSHELRTPLSYIKGYSEAILDGVAkgPQQEKVTQLIHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIVFS 316
Cdd:COG0642 108 EAKSRFLANVSHELRTPLTAIRGYLELLLEELD--EEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 317 QLIEDVLDTYEIKFIEKKIRISTNLNPEII-VMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGI 395
Cdd:COG0642 186 ELLEEVVELFRPLAEEKGIELELDLPDDLPtVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGP 265
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1695318305 396 GIDIEHLENLGERFYRVDkaRSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQ 460
Cdd:COG0642 266 GIPPEDLERIFEPFFRTD--PSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
239-457 |
3.02e-73 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 234.02 E-value: 3.02e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 239 RKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQ-QEKVTQLIHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQ 317
Cdd:TIGR02966 114 RRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEeWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPA 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 318 LIEDVLDTYEIKFIEKKIRISTNLNPEIIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGI 397
Cdd:TIGR02966 194 LLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGI 273
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 398 DIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:TIGR02966 274 APEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESELGKGSTFSFIF 333
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
168-439 |
4.86e-64 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 214.11 E-value: 4.86e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 168 LALAITLLTiwiGRKIIIAITRPLSQMervaNHLATGDFSERITISSEDEIGRLGKAFNKMANSLETEDVKRKEFLANVS 247
Cdd:PRK10549 176 LAALATFLL---ARGLLAPVKRLVEGT----HKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMADIS 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 248 HELRTPLSYIKGYSEAILDGVAKgPQQEKVTQLiHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYE 327
Cdd:PRK10549 249 HELRTPLAVLRGELEAIQDGVRK-FTPESVASL-QAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFR 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 328 IKFIEKKIRISTNLNPEIIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGE 407
Cdd:PRK10549 327 ERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFE 406
|
250 260 270
....*....|....*....|....*....|..
gi 1695318305 408 RFYRVDKARSRQHGGTGLGLAIVRQIVHIHDG 439
Cdd:PRK10549 407 RFYRTEGSRNRASGGSGLGLAICLNIVEAHNG 438
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
7-458 |
8.16e-61 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 205.45 E-value: 8.16e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 7 KLWLTVVCAVFVTVSFLYFVSLYSYEKLYVDNLKDS----LVMEGKRLAAQYD--------KREGISTFEEKVRAFDQIS 74
Cdd:NF012163 8 KLFLAIFATCLLLLIVMHWAVRVSFQRGFIDYIKDGneqrLQRLSDALGEQYAqhgnwrflRNNGDRWVRQLLRTLEHDN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 75 SSDVLFVSNPRDL---SACLPFDVHHHSLISEGD--------RQALLDGKTVTKIGyeehfdrnimgvVIPVLEnkklvg 143
Cdd:NF012163 88 DSDKPGPGLPDHLgwrSRLWLVDANHRFVVGPPDpvsddgtrRPILVNGQEVGALG------------ASPVER------ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 144 ivysyipLKSIKDLIYDMG------LILAPLALAITLLTIWIGRkiiiAITRPLSQMERVANHLATGDFSERITISSEDE 217
Cdd:NF012163 150 -------LTRNTDINFDSQqkraswLIVALALLLAALAAFLLAR----GLLAPVKRLVEATHRLAAGDYTTRVTPTSNDE 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 218 IGRLGKAFNKMANSLETEDVKRKEFLANVSHELRTPLSYIKGYSEAILDGVAKGpQQEKVTQLiHKEADRMQRLVHDLLD 297
Cdd:NF012163 219 LGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGIRKF-TPESLDSL-QAEVGTLTKLVDDLHD 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 298 LAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLNPEIIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIII 377
Cdd:NF012163 297 LSMSDEGALAYQKASVDLVPLLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHI 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 378 TLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:NF012163 377 SASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTL 456
|
.
gi 1695318305 458 K 458
Cdd:NF012163 457 P 457
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
162-463 |
4.94e-57 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 194.41 E-value: 4.94e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 162 GLILAPLALAITLLTIWIGRKIIIAITRPLSQMERVANHLATGDFSERITISSEDEIGRLGKAFNKMANSLET---EDVK 238
Cdd:COG5000 8 LLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEqreELEE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 239 RKEFLANV------------------------------------------------------------------------ 246
Cdd:COG5000 88 RRRYLETIlenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgr 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 247 -----------------------------------------SHELRTPLSYIKGYSEAILDGVAKGPQQ-----EKVTQL 280
Cdd:COG5000 168 rtllvrasplrddgyvivfdditellraerlaawgelarriAHEIKNPLTPIQLSAERLRRKLADKLEEdredlERALDT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 281 IHKEADRMQRLVHDLLDLAQLEgehfPLKKQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLNPEI-IVMIDEDRMQQVLH 359
Cdd:COG5000 248 IIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 360 NVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYrvdkarSRQHGGTGLGLAIVRQIVHIHDG 439
Cdd:COG5000 324 NLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGG 397
|
410 420
....*....|....*....|....
gi 1695318305 440 QWRIESEKGNGTTVSIKLKVQDEE 463
Cdd:COG5000 398 TIELESRPGGGTTFTIRLPLAEEA 421
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
73-452 |
5.54e-52 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 182.92 E-value: 5.54e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 73 ISSSDVLFVSNPRDLSACLP---FDVHHHSLISEGDRQALLDGKT---VTKIGYEEHFDRNIMGVVI------PVLENKK 140
Cdd:NF040691 90 QGAFDVVLLVPGDDPSGLGPrasGSVGLVSQIPEELREAVAGGQVaqqYQSVALPSGDGSSAPALVVgtpvtlPVAGNYE 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 141 LvgivYSYIPLKSIKDLIYDMG--LILAPLALA--ITLLTIWIGRKIiiaiTRPLSQMERVANHLATGDFSERITISSED 216
Cdd:NF040691 170 L----YLLFPLEDEQSTLALVRgtLLLGGLALVvlLGLIAWLVTRQV----VAPVRSAARTAERFAAGDLSERMPVKGED 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 217 EIGRLGKAFNKMANSL-----ETEDVKR--KEFLANVSHELRTPLSYIKGYSEAILDGVAK-GPQQEKVTQLIHKEADRM 288
Cdd:NF040691 242 DLARLARSFNQMADSLqrqirQLEELSRlqQRFVSDVSHELRTPLTTIRMAADVIHDSRDDfDPATARSAELLHTELDRF 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 289 QRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLnPE--IIVMIDEDRMQQVLHNVLDNAI 366
Cdd:NF040691 322 ESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDA-PGtpVVAEVDPRRVERVLRNLVVNAI 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 367 RYTNQnGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHDGQWRIESE 446
Cdd:NF040691 401 EHGEG-KPVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGR 479
|
....*.
gi 1695318305 447 KGNGTT 452
Cdd:NF040691 480 PGQGSQ 485
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
239-457 |
2.72e-49 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 174.04 E-value: 2.72e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 239 RKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEADRMQRLVHDLLDLAQLE-GEHFPLKKQPIVFSQ 317
Cdd:PRK11006 204 RRNFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEaAPTIDLNEKVDVPMM 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 318 LieDVLDTYEIKFIEKKIRISTNLNPEIIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGI 397
Cdd:PRK11006 284 L--RVLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGI 361
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 398 DIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:PRK11006 362 APEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVL 421
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
144-458 |
1.11e-47 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 167.86 E-value: 1.11e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 144 IVYSY------IPLKSIK---------DLIYdmgliLAPLALAITLLTIWIGRKIIIAITRPLSQMERVANHLATGDFSE 208
Cdd:NF012226 31 FIYNYaievgwITLSSLQedwtefhfvDWIW-----LFTVILCGSVISLIIGMKLAQRFIVPINFLADAAKKISQGDLSA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 209 RI---TISSEdEIGRLGKAFNKMANSLETEdVKRKEFL-ANVSHELRTPLSYIKGYSEAILDGVAKGPQQ------EKVT 278
Cdd:NF012226 106 RAedsQIHSA-EISELMHNFNDMAQKLESS-VKNAQVWnAAIAHELRTPITILQGRLQGILDGVFEPDPAlfksllNQVE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 279 QLIHkeadrmqrLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLnPEIIVMIDEDRMQQVL 358
Cdd:NF012226 184 GLSH--------LVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLKMFEDRLEQAQLTIVLNL-TATPVFCDRRRIEQVL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 359 HNVLDNAIRYTNQnGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHD 438
Cdd:NF012226 255 IALIDNAIRYANA-GKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHK 333
|
330 340
....*....|....*....|.
gi 1695318305 439 GQwrIESEKGNGTTV-SIKLK 458
Cdd:NF012226 334 GS--IEYSNSQGNSVfTIKLP 352
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
163-448 |
5.11e-46 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 166.02 E-value: 5.11e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 163 LILAPLALAITLLTIWIGRkiiiAITRPLSQMERVANHLATGDFSERITIS-SEDEIGRLGKAFNKMANSLETEDVKRKE 241
Cdd:TIGR01386 168 LIAVLLVLLTALLGWWITR----LGLEPLRRLSAVAARISPESLDQRLDPSrAPAELRELAQSFNAMLGRLEDAFQRLSQ 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 242 FLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIED 321
Cdd:TIGR01386 244 FSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAK 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 322 VLDTYEIKFIEKKIRIStnLNPEIIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEH 401
Cdd:TIGR01386 324 VAEYFEPLAEERGVRIR--VEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEH 401
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1695318305 402 LENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKG 448
Cdd:TIGR01386 402 LSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDG 448
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
128-459 |
1.92e-45 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 164.63 E-value: 1.92e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 128 IMGVVIPVLENKKLVGIV------YSYIP-LKSIKDLIYDMGLILAPLALAITLLTIWIgrkiiiaITRPLSQMERVANH 200
Cdd:PRK11100 147 VMYVAAPIRDGGRIIGVLsvgkpnSSMAPfIKRSERRILWAGALLLGIALLIGAGVVWW-------LNRSIRRLTRYADA 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 201 LATGDfSERITISSEDEIGRLGKAFNKMANSLETedvkrKEFLANV----SHELRTPLSYIKGYSEaILDGVAKGPQQEK 276
Cdd:PRK11100 220 VTEGK-PVPLPKLGSSELRELAQALESMRVKLEG-----KAYVEQYvqtlTHELKSPLAAIRGAAE-LLQEDPPPEDRAR 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 277 VTQLIHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKKIRIsTNLNPEIIVMIDEDRMQQ 356
Cdd:PRK11100 293 FTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITL-RLRPDDARVLGDPFLLRQ 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 357 VLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFY---RVDKARSrqhgGTGLGLAIVRQI 433
Cdd:PRK11100 372 ALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREV 447
|
330 340
....*....|....*....|....*.
gi 1695318305 434 VHIHDGQWRIESEKGNGTTVSIKLKV 459
Cdd:PRK11100 448 ARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
241-462 |
3.86e-45 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 164.57 E-value: 3.86e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 241 EFLANVSHELRTPLSYIKGYSEAILD--GVAKGPQQEKVTQLIHKEADRMQRLVHDLLDLAQLEGEhfPLKKQPIVFSQL 318
Cdd:COG4251 284 QFAYVASHDLREPLRKISGFSQLLEEdyGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQ--ELEFEPVDLNEL 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 319 IEDVLDTYEIKFIEKKIRISTNLNPEiiVMIDEDRMQQVLHNVLDNAIRYT--NQNGDIIITLRQIDDYCELNIKDTGIG 396
Cdd:COG4251 362 LEEVLEDLEPRIEERGAEIEVGPLPT--VRGDPTLLRQVFQNLISNAIKYSrpGEPPRIEIGAEREGGEWVFSVRDNGIG 439
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1695318305 397 IDIEHLENLGERFYRVDkaRSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQDE 462
Cdd:COG4251 440 IDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
244-457 |
4.12e-45 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 161.12 E-value: 4.12e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 244 ANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQL---IHKEADRMQRLVHDLLDLAQLEgehfPLKKQPIVFSQLIE 320
Cdd:COG4191 147 AGIAHEINNPLAAILGNAELLRRRLEDEPDPEELREAlerILEGAERAAEIVRSLRAFSRRD----EEEREPVDLNELID 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 321 DVLDTYEIKFIEKKIRISTNLNPEII-VMIDEDRMQQVLHNVLDNAIR--YTNQNGDIIITLRQIDDYCELNIKDTGIGI 397
Cdd:COG4191 223 EALELLRPRLKARGIEVELDLPPDLPpVLGDPGQLEQVLLNLLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGI 302
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1695318305 398 DIEHLENLGERFY---RVDKarsrqhgGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:COG4191 303 PPEVLERIFEPFFttkPVGK-------GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
160-445 |
1.41e-41 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 153.22 E-value: 1.41e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 160 DMGLILA-PLALAITLLtIWIgrkiiiaitRP----LSQMERVANHLATGDFSERITISSEDEIGRLGKAFNKMANSLET 234
Cdd:PRK10604 138 DIALLALiGLSLAFPVF-LWM---------RPhwqdMLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINA 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 235 EDVKRKEFLANVSHELRTPLSYIKgYSEAILDGVAKGPQQEkvtqlIHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIV 314
Cdd:PRK10604 208 LIASKKQLIDGIAHELRTPLVRLR-YRLEMSDNLSAAESQA-----LNRDIGQLEALIEELLTYARLDRPQNELHLSEPD 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 315 FSQLIEDVLDTYEIKFIEKKIRISTnLNPEIIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQiDDYCeLNIKDTG 394
Cdd:PRK10604 282 LPAWLSTHLADIQAVTPEKTVRLDT-PHQGDYGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDG-NQAC-LIVEDDG 358
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1695318305 395 IGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHDGQWRIES 445
Cdd:PRK10604 359 PGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDE 409
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
240-464 |
1.70e-41 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 151.15 E-value: 1.70e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 240 KEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEkVTQLIHKEADRMQRLVHDLLDLAQLEgehfPLKKQPIVFSQLI 319
Cdd:COG3852 136 GELAAGLAHEIRNPLTGIRGAAQLLERELPDDELRE-YTQLIIEEADRLNNLVDRLLSFSRPR----PPEREPVNLHEVL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 320 EDVLDTYEIKFiEKKIRISTNLNPEII-VMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLR----------QIDDYCEL 388
Cdd:COG3852 211 ERVLELLRAEA-PKNIRIVRDYDPSLPeVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRverqvtlgglRPRLYVRI 289
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1695318305 389 NIKDTGIGIDIEHLENLGERFYrvdkarSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQDEES 464
Cdd:COG3852 290 EVIDNGPGIPEEILDRIFEPFF------TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAEE 359
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
233-466 |
1.10e-39 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 149.35 E-value: 1.10e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 233 ETEDVKRK--------EFLANVSHELRTPLSYIKGYSEAILDGVAKgpQQEKVTQLIHKEADRMQRLVHDLLDLAQLEGE 304
Cdd:COG5809 256 KLEELLRKseklsvvgELAAGIAHEIRNPLTSLKGFIQLLKDTIDE--EQKTYLDIMLSELDRIESIISEFLVLAKPQAI 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 305 HFplkkQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLNPEI-IVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQID 383
Cdd:COG5809 334 KY----EPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDIpDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAED 409
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 384 -DYCELNIKDTGIGIDIEHLENLGERFYrvdkarSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKL-KVQD 461
Cdd:COG5809 410 dDKVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLpIKLS 483
|
....*
gi 1695318305 462 EESMF 466
Cdd:COG5809 484 EQVSM 488
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
349-460 |
2.25e-37 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 132.39 E-value: 2.25e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 349 IDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKaRSRQHGGTGLGLA 428
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 1695318305 429 IVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQ 460
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
241-465 |
5.50e-37 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 143.18 E-value: 5.50e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 241 EFLANVSHELRTPLSYIKGYSEAILDGvAKGPQQEKVTQLIHKEADRMQRLVHDLLDLAQLEgehfPLKKQPIVFSQLIE 320
Cdd:PRK11360 392 ELVAGVAHEIRNPLTAIRGYVQIWRQQ-TSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPR----ESQWQPVSLNALVE 466
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 321 DVLDTYEIKFIEKKIRISTNLNPEI-IVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQI-DDYCELNIKDTGIGID 398
Cdd:PRK11360 467 EVLQLFQTAGVQARVDFETELDNELpPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYsDGQVAVSIEDNGCGID 546
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1695318305 399 IEHLENLGERFYRVdKARsrqhgGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQDEESM 465
Cdd:PRK11360 547 PELLKKIFDPFFTT-KAK-----GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGNQ 607
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
169-446 |
8.57e-36 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 138.37 E-value: 8.57e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 169 ALAITLLTIWIGRKIIIAITRPLSQMERVANHLATGDFSERITISSED-EIGRLGKAFNKMANSLETEDVKRKEFLANVS 247
Cdd:PRK09835 191 ASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPiELEQLVLSFNHMIERIEDVFTRQSNFSADIA 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 248 HELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYE 327
Cdd:PRK09835 271 HEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFE 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 328 IKFIEKKIRISTNLNPeIIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGE 407
Cdd:PRK09835 351 AWAEERGVELRFVGDP-CQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFD 429
|
250 260 270
....*....|....*....|....*....|....*....
gi 1695318305 408 RFYRVDKARSRQHGGTGLGLAIVRQIVHIHDGQWRIESE 446
Cdd:PRK09835 430 RFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSD 468
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
235-462 |
2.44e-34 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 133.76 E-value: 2.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 235 EDVKRKEFL-------ANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEADRMQRLVHDLLDLAQlegehfP 307
Cdd:PRK10364 226 DEMKRKEKLvalghlaAGVAHEIRNPLSSIKGLAKYFAERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVK------P 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 308 --LKKQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLNPEI-IVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDD 384
Cdd:PRK10364 300 thLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGA 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 385 YCELNIKDTGIGIDIEHLENLgerF--YRVDKARsrqhgGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQDE 462
Cdd:PRK10364 380 GVKISVTDSGKGIAADQLEAI---FtpYFTTKAE-----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNIT 451
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
149-461 |
3.22e-32 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 130.53 E-value: 3.22e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 149 IPLKSIKDLIYDMGLILAPLALAI----TLLTIWIGRkiiIAITRPLSQMERVANHLATGDFSERITISSEDEIGRLGKA 224
Cdd:PRK15347 282 YPRRNLANEALKPALQQLPFALLIlvllTSVLFLLLR---RYLAKPLWRFVDIINKTGPAALEPRLPENRLDELGSIAKA 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 225 FNKMANSLETE-DV-----------------------KRK-EFLANVSHELRTPLSYIKGYSEaILDGVAKGPQQEKVTQ 279
Cdd:PRK15347 359 YNQLLDTLNEQyDTlenkvaertqalaeakqraeqanKRKsEHLTTISHEIRTPLNGVLGALE-LLQNTPLTAEQMDLAD 437
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 280 LIHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLNPEI--IVMIDEDRMQQV 357
Cdd:PRK15347 438 TARQCTLSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVplYLHLDSLRLRQI 517
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 358 LHNVLDNAIRYTnQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKarsrQHGGTGLGLAIVRQIVHIH 437
Cdd:PRK15347 518 LVNLLGNAVKFT-ETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMM 592
|
330 340
....*....|....*....|....
gi 1695318305 438 DGQWRIESEKGNGTTVSIKLKVQD 461
Cdd:PRK15347 593 GGELTLFSTPGVGSCFSLVLPLNE 616
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
350-460 |
1.10e-31 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 117.08 E-value: 1.10e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 350 DEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQiDDYCELNIKDTGIGIDIEHLENLGERFYRVDKarsRQHGGTGLGLAI 429
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSE-GGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|.
gi 1695318305 430 VRQIVHIHDGQWRIESEKGNGTTVSIKLKVQ 460
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
215-450 |
2.73e-31 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 123.91 E-value: 2.73e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 215 EDEIGRLGKAFNKMANSLETEDvkrkEFLANVSHELRTPLSyikGYSEAI--LDGVAKGPQQEKVTQLI---HKEADR-- 287
Cdd:PRK09303 131 SDELFVLRQENETLLEQLKFKD----RVLAMLAHDLRTPLT---AASLALetLELGQIDEDTELKPALIeqlQDQARRql 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 288 --MQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLNPEI-IVMIDEDRMQQVLHNVLDN 364
Cdd:PRK09303 204 eeIERLITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLpSVYADQERIRQVLLNLLDN 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 365 AIRYTNQNGDIIIT-LRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDkaRSRQHGGTGLGLAIVRQIVHIHDGQWRI 443
Cdd:PRK09303 284 AIKYTPEGGTITLSmLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIWV 361
|
....*..
gi 1695318305 444 ESEKGNG 450
Cdd:PRK09303 362 DSEPGQG 368
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
163-452 |
3.21e-31 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 127.59 E-value: 3.21e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 163 LILAPLALAITLLTIWigRKIIIAITRPLSQMERVANHLATGDFSERITISSEDEIGRLG--------KAFNKMANSLET 234
Cdd:TIGR02956 334 LITGMLGLVILVFIMW--RVVYRSVILRLNQHTQALLRLALGDLDISLDARGDDELAHMGraieafrdTAAHNLKLQADE 411
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 235 EDVKRK------------------------------------------------EFLANVSHELRTPLSYIKGYSEaILD 266
Cdd:TIGR02956 412 RQVAQElqehkesleqlvaqrtqelaetnerlnaevknhakaraeaeeanraksAFLATMSHEIRTPLNGILGTLE-LLG 490
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 267 GVAKGPQQEKVTQLIHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLN---P 343
Cdd:TIGR02956 491 DTGLTSQQQQYLQVINRSGESLLDILNDILDYSKIEAGHLSISPRPFDLNALLDDVHHLMVSRAQLKGIQLRLNIPeqlP 570
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 344 EIIVmIDEDRMQQVLHNVLDNAIRYTNQnGDIIITLRQIDDYCEL-NIKDTGIGIDIEHLENLGERFYRVDKARSRqhGG 422
Cdd:TIGR02956 571 NWWQ-GDGPRIRQVLINLVGNAIKFTDR-GSVVLRVSLNDDSSLLfEVEDTGCGIAEEEQATLFDAFTQADGRRRS--GG 646
|
330 340 350
....*....|....*....|....*....|
gi 1695318305 423 TGLGLAIVRQIVHIHDGQWRIESEKGNGTT 452
Cdd:TIGR02956 647 TGLGLAISQRLVEAMDGELGVESELGVGSC 676
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
354-459 |
1.43e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 114.13 E-value: 1.43e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 354 MQQVLHNVLDNAIRYTNQnGDIIITLR---QIDDYCELN--IKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLA 428
Cdd:cd16922 1 LRQILLNLLGNAIKFTEE-GEVTLRVSleeEEEDGVQLRfsVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|.
gi 1695318305 429 IVRQIVHIHDGQWRIESEKGNGTTVSIKLKV 459
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-458 |
1.97e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 111.02 E-value: 1.97e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 350 DEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAI 429
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 1695318305 430 VRQIVHIHDGQWRIESEKGNGTTVSIKLK 458
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
244-460 |
6.77e-29 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 118.68 E-value: 6.77e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 244 ANVSHELRTPLSYIKGYSEAILDGVAKgpqQEKVTQLIHKEADRMQRLVHDLLDLAQLEgehfPLKKQPIVFSQLIEDVL 323
Cdd:COG5805 292 AGIAHEIRNPLTSIKGFLQLLQPGIED---KEEYFDIMLSELDRIESIISEFLALAKPQ----AVNKEKENINELIQDVV 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 324 DTYEIKFIEKKIRISTNLNPEII-VMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHL 402
Cdd:COG5805 365 TLLETEAILHNIQIRLELLDEDPfIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPEERL 444
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1695318305 403 ENLGERFYrvdkarSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQ 460
Cdd:COG5805 445 KKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
165-464 |
1.68e-28 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 115.45 E-value: 1.68e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 165 LAPlALAITLLTIWIGRKIIIAITRPLSQM-----ERVANHLATGDFSeritiSSEDEIGRLGKAFN----KMANSLETE 235
Cdd:PRK10755 64 LVP-SLVMVSLTLLICFQAVRWITRPLAELqkeleARTADNLTPIAIH-----SSTLEIEAVTSALNqlvsRLTSTLDQE 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 236 dvkrKEFLANVSHELRTPLSYIKGYseaiLDGVAK-GPQQekVTQLIhKEADRMQRLVHDLLDLAQLE-----GEHFPLK 309
Cdd:PRK10755 138 ----RLFTADVAHELRTPLAGIRLH----LELLEKqHHID--VAPLI-ARLDQMMHTVEQLLQLARAGqsfssGHYQTVK 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 310 kqpivfsqLIEDVLDTYEIKFIEK-KIRISTNLNPE----IIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDD 384
Cdd:PRK10755 207 --------LLEDVILPSQDELSEMlEQRQQTLLLPEsaadITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 385 YCELNIKDTGIGIDIEHLENLGERFYRVDkarsRQHGGTGLGLAIVRQIVHIHDGQWRIESEK-GNGTTVSIKLKVQDEE 463
Cdd:PRK10755 279 GAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQFFLQNRQeRSGTRAWVWLPKAQNV 354
|
.
gi 1695318305 464 S 464
Cdd:PRK10755 355 A 355
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
163-439 |
3.70e-28 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 116.18 E-value: 3.70e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 163 LILAPLALAITLLTIWIGRkiiiAITRPLSQMERVANHLATGDFseriTISSEDEIG-----RLGKAFNKMANSLETEDV 237
Cdd:PRK09470 170 LLLLVTMLVSTPLLLWLAW----SLAKPARKLKNAADEVAQGNL----RQHPELETGpqefrQAGASFNQMVTALERMMT 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 238 KRKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKvtqlIHKEADRMQRLVHDLLDLA------QLEGEHFPLkkq 311
Cdd:PRK09470 242 SQQRLLSDISHELRTPLTRLQLATALLRRRQGESKELER----IETEAQRLDSMINDLLVLSrnqqknHLERETFKA--- 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 312 pivfSQLIEDVLD--TYEIKFIEKKIRISTNL-------NPEIIVmidedrmqQVLHNVLDNAIRYTNQNgdIIITLRQI 382
Cdd:PRK09470 315 ----NSLWSEVLEdaKFEAEQMGKSLTVSAPPgpwpingNPNALA--------SALENIVRNALRYSHTK--IEVAFSVD 380
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1695318305 383 DDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHDG 439
Cdd:PRK09470 381 KDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRG 437
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-454 |
3.96e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 107.67 E-value: 3.96e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 360 NVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHDG 439
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRHDA 86
|
90
....*....|....*
gi 1695318305 440 QWRIESEKGNGTTVS 454
Cdd:cd16952 87 RLLIASELGKGSRFT 101
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
228-457 |
6.45e-28 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 117.38 E-value: 6.45e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 228 MANSLETEDVKRKEFLANVSHELRTPLSYIKGYSEAIldgvakgpqQekvTQLIHKEADR----MQ-------RLVHDLL 296
Cdd:PRK10841 436 MAQAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLL---------Q---TKELPKGVDRlvtaMNnssslllKIISDIL 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 297 DLAQLEGEHfpLKKQPIVFS--QLIEDVLDTYEIKFIEKKIRISTNLNPEIIVMIDED--RMQQVLHNVLDNAIRYTNqN 372
Cdd:PRK10841 504 DFSKIESEQ--LKIEPREFSprEVINHITANYLPLVVKKRLGLYCFIEPDVPVALNGDpmRLQQVISNLLSNAIKFTD-T 580
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 373 GDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTT 452
Cdd:PRK10841 581 GCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQ 660
|
....*
gi 1695318305 453 VSIKL 457
Cdd:PRK10841 661 FTIRI 665
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
241-452 |
1.15e-27 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 116.87 E-value: 1.15e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 241 EFLANVSHELRTPLSYIKGYSEAILdgvaKGP----QQEKVtQLIHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIVFS 316
Cdd:PRK11107 295 EFLANMSHELRTPLNGVIGFTRQTL----KTPltptQRDYL-QTIERSANNLLAIINDILDFSKLEAGKLVLENIPFSLR 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 317 QLIEDVldtyeIKFI-----EKKIRISTNLNPEI--IVMIDEDRMQQVLHNVLDNAIRYTNQ-NGDIIITLRQI-DDYCE 387
Cdd:PRK11107 370 ETLDEV-----VTLLahsahEKGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIKFTESgNIDILVELRALsNTKVQ 444
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1695318305 388 LN--IKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTT 452
Cdd:PRK11107 445 LEvqIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGST 511
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
149-457 |
9.45e-27 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 111.93 E-value: 9.45e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 149 IPLKSIKDliYDmgliLAPL---ALAITLLTIWIGRKIIIAITRPLSQMERVANHLATGDFSERITISSEDEIGRLGKAF 225
Cdd:PRK09467 142 VPLTEIHQ--GD----FSPLfryTLAIGLLSVAGGWLFIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAF 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 226 NKMANSLETEDVKRKEFLANVSHELRTPLSYIKGYSEAIldgvakGPQQEKVTQLIHKEADRMQRLVHDLLD-LAQLEGE 304
Cdd:PRK09467 216 NQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMM------SEEDGYLAESINKDIEECNAIIEQFIDyLRTGQEM 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 305 HFplkkQPIVFSQLIEDVLDT---YEIKfiekkirISTNLNPEII-VMIDEDRMQQVLHNVLDNAIRYTNqnGDIIITLR 380
Cdd:PRK09467 290 PM----EMADLNALLGEVIAAesgYERE-------IETALQPGPIeVPMNPIAIKRALANLVVNAARYGN--GWIKVSSG 356
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1695318305 381 QIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQhgGTGLGLAIVRQIVHIHDGQWRI-ESEKGnGTTVSIKL 457
Cdd:PRK09467 357 TEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELgNSEEG-GLSARAWL 431
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
197-450 |
1.92e-26 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 112.82 E-value: 1.92e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 197 VANHLatgdfsERITISSEDEIGRLGKAFNKMANSLetedvkrkefLANVSHELRTPLSYIKGYSEAI-LDGVAKG-PQQ 274
Cdd:PRK10490 638 IANAL------ERLTLTASEEQARLASEREQLRNAL----------LAALSHDLRTPLTVLFGQAEILtLDLASEGsPHA 701
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 275 EKVTQLihkeadRMQ-----RLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKKIRISTnlnPEIIVMI 349
Cdd:PRK10490 702 RQASEI------RQQvlnttRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGSALQMLEPGLSGHPINLSL---PEPLTLI 772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 350 DEDR--MQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQhgGTGLGL 427
Cdd:PRK10490 773 HVDGplFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIP--GVGLGL 850
|
250 260
....*....|....*....|...
gi 1695318305 428 AIVRQIVHIHDGQWRIESEKGNG 450
Cdd:PRK10490 851 AICRAIVEVHGGTIWAENRPEGG 873
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
163-440 |
2.61e-26 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 110.89 E-value: 2.61e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 163 LILAPLALAItlltiwigrkIIIAITRPLSQMERVANHLATGDFSERITISSE---DEIGRLGKAFNKMANSLETEDVKR 239
Cdd:PRK10337 168 LVALPIMLII----------LMVLLGRELAPLKKLALALRMRDPDSETPLNATgvpSEVRPLVEALNQLFARTHAMMVRE 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 240 KEFLANVSHELRTPLSYIKGYSE-AILDGVAKGPQQEKVTQLiHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQL 318
Cdd:PRK10337 238 RRFTSDAAHELRSPLAALKVQTEvAQLSDDDPQARKKALLQL-HAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDL 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 319 IED-VLDTYEiKFIEKKIRISTNLNPEIIVmidedRMQQVL------HNVLDNAIRYTNQNGDIIITLrqidDYCELNIK 391
Cdd:PRK10337 317 LQSaVMDIYH-TAQQAGIDVRLTLNAHPVI-----RTGQPLllsllvRNLLDNAIRYSPQGSVVDVTL----NARNFTVR 386
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1695318305 392 DTGIGIDIEHLENLGERFYRvdkARSRQHGGTGLGLAIVRQIVHIHDGQ 440
Cdd:PRK10337 387 DNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMN 432
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
163-460 |
1.10e-25 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 110.77 E-value: 1.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 163 LILAPLALAITLLTIWigRKIIIAITRPLSQMERVANHLATGD----FSERITISSEDEIGRLGKAFNKMANSL------ 232
Cdd:PRK11466 334 LLLGMVSLCALILILW--RVVYRSVTRPLAEQTQALQRLLDGDidspFPETAGVRELDTIGRLMDAFRSNVHALnrhreq 411
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 233 --------------------------ETEDVKRKEFLANVSHELRTPLSYIKGYSEAILDGVAKgPQQEKVTQLIHKEAD 286
Cdd:PRK11466 412 laaqvkartaelqelviehrqaraeaEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPAL-NAQRDDLRAITDSGE 490
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 287 RMQRLVHDLLDLAQLE--GEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLNPEI--IVMIDEDRMQQVLHNVL 362
Cdd:PRK11466 491 SLLTILNDILDYSAIEagGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLptALMGDPRRIRQVITNLL 570
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 363 DNAIRYTNQnGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARsrqhGGTGLGLAIVRQIVHIHDGQWR 442
Cdd:PRK11466 571 SNALRFTDE-GSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELS 645
|
330
....*....|....*...
gi 1695318305 443 IESEKGNGTTVSIKLKVQ 460
Cdd:PRK11466 646 ATSTPEVGSCFCLRLPLR 663
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
229-463 |
4.49e-25 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 108.87 E-value: 4.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 229 ANSLETEDVKRKEFLANVSHELRTPLSYIKGYSEAILDgVAKGPQQEKVTQLIHKEADRMQRLVHDLLDLAQLEGEHFPL 308
Cdd:PRK11091 273 QDALEKASRDKTTFISTISHELRTPLNGIVGLSRILLD-TELTAEQRKYLKTIHVSAITLGNIFNDIIDMDKMERRKLQL 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 309 KKQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLNPE--IIVMIDEDRMQQVLHNVLDNAIRYTnQNGDIIITL-RQIDDY 385
Cdd:PRK11091 352 DNQPIDFTDFLADLENLSGLQAEQKGLRFDLEPLLPlpHKVITDGTRLRQILWNLISNAVKFT-QQGGVTVRVrYEEGDM 430
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 386 CELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHG-GTGLGLAIVRQIVHIHDGQWRIESEKGNGT--TVSIKLKVQDE 462
Cdd:PRK11091 431 LTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPAtGTGIGLAVSKRLAQAMGGDITVTSEEGKGScfTLTIHAPAVAE 510
|
.
gi 1695318305 463 E 463
Cdd:PRK11091 511 E 511
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
214-460 |
7.78e-24 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 105.20 E-value: 7.78e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 214 SEDEIGRLGKAFNKMANSleteDVKRKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEADRMQRLVH 293
Cdd:PRK09959 691 TRDLIHALEVERNKAINA----TVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIG 766
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 294 DLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEIKFIEKKIRI--STNLNPEIIVMIDEDRMQQVLHNVLDNAIRYTNQ 371
Cdd:PRK09959 767 EILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALscSSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTE 846
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 372 NG-DIIITLRQIDD---YCELNIKDTGIGIDIEHLENLGERFYRVdkARSRQHGGTGLGLAIVRQIVHIHDGQWRIESEK 447
Cdd:PRK09959 847 GAvKITTSLGHIDDnhaVIKMTIMDSGSGLSQEEQQQLFKRYSQT--SAGRQQTGSGLGLMICKELIKNMQGDLSLESHP 924
|
250
....*....|...
gi 1695318305 448 GNGTTVSIKLKVQ 460
Cdd:PRK09959 925 GIGTTFTITIPVE 937
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
17-462 |
2.10e-22 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 99.32 E-value: 2.10e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 17 FVTVSFLYFVSLYSYEKLYVDNLKDSLVMEGKRLAAQYDKREGISTFEEKVRAFDQISSSDVLFVSNPRDLSACLPFDVH 96
Cdd:COG2972 11 VLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 97 HHSLISEGDRQALLDGKTVTKIGYEEHFDRNIMGVVIPVLENKKLVGIVYSYIPLKSIKDLIYDMGLILAPLALAITLLT 176
Cdd:COG2972 91 LLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 177 IWIGRKIIIAITRPLSQMERVANHLATGDFSeRITISSEDEIGRLGKAFNKMANSLET--EDVKRKEfLANVSHELRT-- 252
Cdd:COG2972 171 LLLSYLLSRSITRPIKRLKKAMKKVEKGDLV-RLEVSGNDEIGILARSFNEMVERIKEliEEVYELE-LEKKEAELKAlq 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 253 ----P------LSYIKGYSEAildgvakgpqqekvtqlihKEADRMQRLVHDLLDL----AQLEGEHFPLKKQpIvfsQL 318
Cdd:COG2972 249 aqinPhflfntLNSIRWLAEL-------------------EDPEEAEEMLEALSKLlrysLSKGDELVTLEEE-L---EL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 319 IEDVLDTYEIKFiEKKIRISTNLNPEIIVMIDEDRMQQVLhnvLDNAIRY----TNQNGDIIITLRQIDDYCELNIKDTG 394
Cdd:COG2972 306 IKSYLEIQKLRF-GDRLEVEIEIDEELLDLLIPKLILQPL---VENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNG 381
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1695318305 395 IGIDIEHLENLGERFyrvdkarSRQHGGTGLGLAIVRQIVHIHDG---QWRIESEKGNGTTVSIKLKVQDE 462
Cdd:COG2972 382 VGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIRIPLEEE 445
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-457 |
2.43e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 91.70 E-value: 2.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 345 IIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLrQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKarsRQHGGTG 424
Cdd:cd16940 5 IQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKL-SADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSG 80
|
90 100 110
....*....|....*....|....*....|...
gi 1695318305 425 LGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:cd16940 81 LGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-457 |
7.18e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 87.38 E-value: 7.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 356 QVLHNVLDNAIRYTNQngDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVH 435
Cdd:cd16949 3 RALENVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|..
gi 1695318305 436 IHDGQWRIESEKGNGTTVSIKL 457
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWL 102
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-457 |
1.86e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 85.90 E-value: 1.86e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 354 MQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKarSRQHGGTGLGLAIVRQI 433
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....
gi 1695318305 434 VHIHDGQWRIESEkGNGTTVSIKL 457
Cdd:cd16923 79 IELHGGSASAEYD-DNHDLFKVRL 101
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
134-457 |
4.49e-20 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 93.27 E-value: 4.49e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 134 PVLENKKLVGIVYSYIPLKSIKDLIYD-----MGLILApLALAITLLTIWIGRKIIIAITRPLSQMERVANhlATGDFSE 208
Cdd:TIGR03785 377 PIWIDTEVLGAVIAEQTTNGIRTLRNSaleklFNVILA-IMSIGTLALFGFASWISWRIRRLSDDAEAAID--SQGRISG 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 209 RITIS-SEDEIGRLGKAFNKMANSLETEDVKRKEFLANVSHELRTPLSYIKgyseAILDGVAKGPQQEKVTQLI---HKE 284
Cdd:TIGR03785 454 AIPASrSRDEIGDLSRSFAQMVARLRQYTHYLENMSSRLSHELRTPVAVVR----SSLENLELQALEQEKQKYLeraREG 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 285 ADRMQRLVHDLLDLAQLEG-------EHFPLKKqpiVFSQLIEDVLDTYEIKFIEKKIRIS---TNLNPEIIVmidedrm 354
Cdd:TIGR03785 530 TERLSMILNNMSEATRLEQaiqsaevEDFDLSE---VLSGCMQGYQMTYPPQRFELNIPETplvMRGSPELIA------- 599
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 355 qQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDiehlENLGERFY------RVDKARSRQHggTGLGLA 428
Cdd:TIGR03785 600 -QMLDKLVDNAREFSPEDGLIEVGLSQNKSHALLTVSNEGPPLP----EDMGEQLFdsmvsvRDQGAQDQPH--LGLGLY 672
|
330 340 350
....*....|....*....|....*....|
gi 1695318305 429 IVRQIVHIHDGQWRIES-EKGNGTTVSIKL 457
Cdd:TIGR03785 673 IVRLIADFHQGRIQAENrQQNDGVVFRISL 702
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
350-457 |
1.64e-18 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 81.00 E-value: 1.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 350 DEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQID-DYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLA 428
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100
....*....|....*....|....*....
gi 1695318305 429 IVRQIVHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVEL 109
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
239-300 |
3.60e-18 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 78.41 E-value: 3.60e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1695318305 239 RKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEADRMQRLVHDLLDLAQ 300
Cdd:cd00082 4 KGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
246-460 |
7.59e-18 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 86.66 E-value: 7.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 246 VSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEADRMQRLVHDLLDLaqleGEHFPLKKQPIVFSQLIEDVLDT 325
Cdd:PRK13837 457 IAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAF----GRKGERNTKPFDLSELVTEIAPL 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 326 yeikfiekkIRISTNLNPEIIVMIDEDRM---------QQVLHNVLDNAIRYTNQNGDIIITLRQID------------- 383
Cdd:PRK13837 533 ---------LRVSLPPGVELDFDQDQEPAvvegnpaelQQVLMNLCSNAAQAMDGAGRVDISLSRAKlrapkvlshgvlp 603
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1695318305 384 --DYCELNIKDTGIGIDIEHLENLGERFYrvdKARSrqhGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQ 460
Cdd:PRK13837 604 pgRYVLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPS 676
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
318-457 |
9.84e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 79.21 E-value: 9.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 318 LIEDVLDTYEIKFIEKKIRISTNLNPEIIVMIDEDRMQQVLHNVLDNAIRYTnqNGDIIITLRQIDDYCELNIKDTGIGI 397
Cdd:cd16954 2 LLDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGV 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 398 DIEHLENLGERFYRVDkarsRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:cd16954 80 PESQRSKIFQRGQRLD----EQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
238-304 |
1.46e-17 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 76.48 E-value: 1.46e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1695318305 238 KRKEFLANVSHELRTPLSYIKGYSEAILDGVAkGPQQEKVTQLIHKEADRMQRLVHDLLDLAQLEGE 304
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKL-DEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-457 |
2.89e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 76.98 E-value: 2.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 354 MQQVLHNVLDNAIRYT--NQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKarSRQHGGTGLGLAIVR 431
Cdd:cd16921 1 LGQVLTNLLGNAIKFRrpRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*.
gi 1695318305 432 QIVHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTL 104
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
238-304 |
4.67e-17 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 75.30 E-value: 4.67e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1695318305 238 KRKEFLANVSHELRTPLSYIKGYSEAILDGvAKGPQQEKVTQLIHKEADRMQRLVHDLLDLAQLEGE 304
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDT-ELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
163-462 |
1.29e-16 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 81.43 E-value: 1.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 163 LILAPLALAITLLTIWIGRKIIIAITRPLSQMERVANHLatgdfserITISSEDEIGRLGKAFNKMANSLETedvkrkef 242
Cdd:COG3290 129 VLAEVLETGERDEEILLNGRVLVVNRVPIRDDGRVVGAV--------ATFRDRTELERLEEELEGVKELAEA-------- 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 243 LANVSHELRTPLSYIKGYSEAIldgvakgpQQEKVTQLIHKEADRMQRLVHDLLDlaqlegehfplKKQPIVFSQLIEDV 322
Cdd:COG3290 193 LRAQRHDFRNHLHTISGLLQLG--------EYDEALEYIDEISEELQELIDSLLS-----------RIGNPVLAALLLGK 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 323 LDTYEIKFIEKKIRISTNLNPEIIVMIDEDRmqqVLHNVLDNAIRYTNQNGD----IIITLRQIDDYCELNIKDTGIGID 398
Cdd:COG3290 254 AARARERGIDLTIDIDSDLPDLPLSDTDLVT---ILGNLLDNAIEAVEKLPEeerrVELSIRDDGDELVIEVEDSGPGIP 330
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1695318305 399 IEHLENLGERFYRvdkarSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQDE 462
Cdd:COG3290 331 EELLEKIFERGFS-----TKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
163-448 |
1.40e-16 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 82.43 E-value: 1.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 163 LILAPLALAITLLTIW--IGRKIIIAITRpLSQ-MERVANhlatGDFSERITISSEDEIGRLGKA---FNKMAN----SL 232
Cdd:COG4192 329 LAIALLSLLLAVLINYfyVRRRLVKRLNA-LSDaMAAIAA----GDLDVPIPVDGNDEIGRIARLlrvFRDQAIektqEL 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 233 ETEDVKRKEFLAN-----------------------VSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKE--ADR 287
Cdd:COG4192 404 ETEIEERKRIEKNlrqtqdeliqaakmavvgqtmtsLAHELNQPLNAMSMYLFSAKKALEQENYAQLPTSLDKIEglIER 483
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 288 MQRLVHDLldlaqlegEHFPLKK----QPIVFSQLIEDVLDTYEIKfiEKKIRISTNLNPEIIVMIDEDRMQQVLHNVLD 363
Cdd:COG4192 484 MDKIIKSL--------RQFSRKSdtplQPVDLRQVIEQAWELVESR--AKPQQITLHIPDDLMVQGDQVLLEQVLVNLLV 553
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 364 NAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIehLENLGERFYrvdkarSRQHGGTGLGLAIVRQIVHIHDGQWRI 443
Cdd:COG4192 554 NALDAVATQPQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYL 625
|
....*..
gi 1695318305 444 ES--EKG 448
Cdd:COG4192 626 AStlERG 632
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-448 |
1.44e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 75.16 E-value: 1.44e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 354 MQQVLHNVLDNAIRYTNQNGDIIITLRqiDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQI 433
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVS--GGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90
....*....|....*.
gi 1695318305 434 VHIHDGQWRI-ESEKG 448
Cdd:cd16939 79 ALWHGGHVECdDSELG 94
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-456 |
6.48e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 73.26 E-value: 6.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 350 DEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARsRQHGGTGLGLAI 429
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90 100
....*....|....*....|....*..
gi 1695318305 430 VRQIVHIHDGQWRIESEKGNGTTVSIK 456
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
188-232 |
1.28e-15 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 70.55 E-value: 1.28e-15
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1695318305 188 TRPLSQMERVANHLATGDFSERITISSEDEIGRLGKAFNKMANSL 232
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-457 |
6.25e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 70.53 E-value: 6.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 353 RMQ--QVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSrqhgGTGLGLAIV 430
Cdd:cd16943 1 PSQlnQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLS 76
|
90 100
....*....|....*....|....*..
gi 1695318305 431 RQIVHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIIL 103
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-450 |
6.38e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 70.57 E-value: 6.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 354 MQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHgGTGLGLAIVRQI 433
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQK-STGLGLAFVQEV 83
|
90
....*....|....*..
gi 1695318305 434 VHIHDGQWRIESEKGNG 450
Cdd:cd16945 84 AQLHGGRITLRNRPDGV 100
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-457 |
7.92e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 70.17 E-value: 7.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 354 MQQVLHNVLDNAIRYTNqnGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRqhGGTGLGLAIVRQI 433
Cdd:cd16950 1 LKRVLSNLVDNALRYGG--GWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGT--SGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....
gi 1695318305 434 VHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIEL 100
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-458 |
8.94e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 70.62 E-value: 8.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 345 IIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGTG 424
Cdd:cd16947 12 IYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNG 91
|
90 100 110
....*....|....*....|....*....|....
gi 1695318305 425 LGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLK 458
Cdd:cd16947 92 LGLTITKRLAESMGGSIYVNSKPYEKTVFTVTLK 125
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-455 |
1.66e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 66.54 E-value: 1.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 350 DEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKARsRQHGGTGLGLAI 429
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYL 80
|
90 100
....*....|....*....|....*.
gi 1695318305 430 VRQIVHIHDGQWRIESEKGNGTTVSI 455
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTI 106
|
|
| HAMP |
pfam00672 |
HAMP domain; |
183-234 |
1.79e-13 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 64.57 E-value: 1.79e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1695318305 183 IIIAITRPLSQMERVANHLATGDFSERITISSEDEIGRLGKAFNKMANSLET 234
Cdd:pfam00672 2 LARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
240-457 |
5.84e-13 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 69.72 E-value: 5.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 240 KEFLANVSHELRTPLSYIKGYSEaILDGVAKGPQQEKVTQLIHKEADRMQRLVHDLLdlaqleGEHFPLKKQPIVFSQLI 319
Cdd:PRK11073 131 RDLVRGLAHEIKNPLGGLRGAAQ-LLSKALPDPALTEYTKVIIEQADRLRNLVDRLL------GPQRPGTHVTESIHKVA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 320 EDVLDTYEIKfIEKKIRISTNLNPEII-VMIDEDRMQQVLHNVLDNAIRYTNQNGDIII----TLRQIDDY-------CE 387
Cdd:PRK11073 204 ERVVQLVSLE-LPDNVRLIRDYDPSLPeLAHDPDQIEQVLLNIVRNALQALGPEGGTITlrtrTAFQLTLHgeryrlaAR 282
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 388 LNIKDTGIGIDIEHLENLgerFYRVDKARSrqhGGTGLGLAIVRQIVHIHDGQWRIESEKGNgTTVSIKL 457
Cdd:PRK11073 283 IDIEDNGPGIPPHLQDTL---FYPMVSGRE---GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYL 345
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
15-463 |
7.59e-13 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 70.53 E-value: 7.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 15 AVFVTVSFLYFVSLYSYEKLYVDNLKDSLVMEGKRLAAQYDKREGISTFEEKVRAFDQISSSDVLFVSNPRDLSACLPFD 94
Cdd:COG2770 65 VLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 95 VHHHSLISEGDRQALLDGKTVTKIGYEEHFDRNIMGVVIPVLENKKLVGIVYSYIPLKSIKDLIYDMGLILApLALAITL 174
Cdd:COG2770 145 LGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLL-LALLALL 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 175 LTIWIGRKIIIAITRPLSQMERVANHLATGDFSERITISSEDEIGRLGKAFNKMANSLET------EDVKRKEFLANVSH 248
Cdd:COG2770 224 LALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLREsieeaeEEEELAEAELARLL 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 249 ELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDTYEI 328
Cdd:COG2770 304 EALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALA 383
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 329 KFIEKKIRISTNLNPEIIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGER 408
Cdd:COG2770 384 LEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAE 463
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1695318305 409 FYRVDKARSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQDEE 463
Cdd:COG2770 464 ELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLLL 518
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
187-234 |
9.27e-13 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 62.65 E-value: 9.27e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1695318305 187 ITRPLSQMERVANHLATGDFSERITISSEDEIGRLGKAFNKMANSLET 234
Cdd:smart00304 3 LLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEE 50
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
124-234 |
2.16e-12 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 68.89 E-value: 2.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 124 FDRNIMGVVIPVLENKKLVGIVYSYIPLKSIKDLIYDMGLILAPLALAITLLTIWIGRKIIIAITRPLSQMERVANHLAT 203
Cdd:COG0840 143 LALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAE 222
|
90 100 110
....*....|....*....|....*....|.
gi 1695318305 204 GDFSERITISSEDEIGRLGKAFNKMANSLET 234
Cdd:COG0840 223 GDLTVRIDVDSKDEIGQLADAFNRMIENLRE 253
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
161-463 |
3.91e-12 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 67.99 E-value: 3.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 161 MGLILAPLALAITLLTIWIGRKiiiAITRPLSQMERVANHLATGDFSERITISSEDEIGRLGKAFNKMAN-------SLE 233
Cdd:COG3850 119 LALLRLLLALLLALLLAYLLRR---RIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADelqelyaELE 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 234 TEDVKRKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPI 313
Cdd:COG3850 196 EEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLA 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 314 VFSQLIEDVLDTYEIKFIEKKIRISTNLNPEIIVMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDT 393
Cdd:COG3850 276 SALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEA 355
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 394 GIGIDIEHLENLGERFYRVDKARSRQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQDEE 463
Cdd:COG3850 356 AAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGGLVVLIVSIIA 425
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-460 |
7.75e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 61.82 E-value: 7.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 356 QVLHNVLDNAIRYT-NQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFY--RVDKARSRQHggTGLGLAIVRQ 432
Cdd:cd16953 3 QVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYteRPANEAFGQH--SGLGLSISRQ 80
|
90 100
....*....|....*....|....*...
gi 1695318305 433 IVHIHDGQWRIESEKGNGTTVSIKLKVQ 460
Cdd:cd16953 81 IIEAHGGISVAENHNQPGQVIGARFTVQ 108
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-457 |
9.30e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 61.53 E-value: 9.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 357 VLHNVLDNAI----RYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRvdkarSRQHGGTGLGLAIVRQ 432
Cdd:cd16915 4 IVGNLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVS-----TKGQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*
gi 1695318305 433 IVHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRI 103
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
243-445 |
1.55e-11 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 66.19 E-value: 1.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 243 LANVSHELRTPLSYIKGYSEAIldgvaKGPQQEKVTQ---LIHKEADRMQRLVHDLLDLAQLEGEHFPLKKQ----PIVF 315
Cdd:PRK10815 270 LTDLTHSLKTPLAVLQSTLRSL-----RSGKQMSVEQaepIMLEQISRISQQIGYYLHRASMRSEHNLLSRElhsvAPLL 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 316 SQLIEDVLDTYEikfiEKKIRISTNLNPEIIVMIDEDRMQQVLHNVLDNAIRYTNQNgdIIITLRQIDDYCELNIKDTGI 395
Cdd:PRK10815 345 DNLTSALNKVYQ----RKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEF--VEISARQTDEHLHIVVEDDGP 418
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1695318305 396 GIDIEHLENLGERFYRVDKARSrqhgGTGLGLAIVRQIVHIHDGQWRIES 445
Cdd:PRK10815 419 GIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGD 464
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
168-437 |
2.03e-11 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 65.63 E-value: 2.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 168 LALAITLLTIWIGRKIiiaitRPLSQMERVANHLATGDFSERITISSEDEIGRLGKAFNKMANSLETEDVKRKEFLANVS 247
Cdd:NF038389 140 LILLLLILYISVLKSL-----KPLKKLKKQIKKFANGDFDFIKSESNGDEIGEVANEFDKAVKKIKALNESRQLFLRNIM 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 248 HELRTPLSyiKG--YSEAILDGVakgpQQEKvtqlIHKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQLIEDVLDt 325
Cdd:NF038389 215 HELKTPIT--KGriVAEMLEDEK----QKER----LISIFERLESLINEFAKIEQLTSKNYKLNKKEYRLSDIIDEAID- 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 326 yeIKFIEKKIRISTNLNPEIIVMIDEDRMQQVLHNVLDNAIRYTNQNgdiIITLRQIDDYCElnIKDTGIGIDIEhLENL 405
Cdd:NF038389 284 --MLMIDDSSVIIKVSLEDFKLNVDFELFSLAIKNLIDNAIKYSPDK---KVTIEIKGDKIE--FKNKGEPLEEP-LEYY 355
|
250 260 270
....*....|....*....|....*....|..
gi 1695318305 406 GERFYrvdKARSRQHGGTGLGLAIVRQIVHIH 437
Cdd:NF038389 356 FEPFF---KGNEKSKSGFGLGLYIVKNILKAH 384
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
291-464 |
4.74e-11 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 64.54 E-value: 4.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 291 LVHDLLdlaqLEGEHFplkkQPIVFSQLIEDVLDTYEIKFIEKKIRISTNLNPeiiVMIDEDRMQQ---VLHNVLDNAIR 367
Cdd:COG3920 345 LVHELL----YQSEDW----EGVDLRDYLRELLEPLRDSYGGRGIRIELDGPD---VELPADAAVPlglILNELVTNALK 413
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 368 Y---TNQNGDIIITLRQIDDYCELNIKDTGIGIDIEhlenlgerfyrVDKARSRqhggtGLGLAIVRQIVHIHDGQWRIE 444
Cdd:COG3920 414 HaflSGEGGRIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPARK-----GLGLRLIRALVRQLGGTLELD 477
|
170 180
....*....|....*....|
gi 1695318305 445 SEkgNGTTVSIKLKVQDEES 464
Cdd:COG3920 478 RP--EGTRVRITFPLAELAA 495
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-457 |
2.33e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 57.47 E-value: 2.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 354 MQQVLHNVLDNAIRYTN--QNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRvdkarSRQHG-GTGLGLAIV 430
Cdd:cd16976 1 IQQVLMNLLQNALDAMGkvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 1695318305 431 RQIVHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
239-463 |
4.09e-10 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 62.26 E-value: 4.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 239 RKEFLANVSHELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIhKEADRMQRLVHDLLDLAQLEGEHFPLKKQPIVFSQL 318
Cdd:PRK10618 450 RKAFLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPELDQLA-EQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDL 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 319 IEDVLDTYEIKFIEK--KIRISTNLNPEIIVMIDEDRMQQVLHNVLDNAIRyTNQNGDIIITLRQIDDYCE---LNIKDT 393
Cdd:PRK10618 529 IDEVLPEVLPAIKRKglQLLIHNHLKAEQLRIGDRDALRKILLLLLNYAIT-TTAYGKITLEVDQDESSPDrltIRILDT 607
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1695318305 394 GIGIDIEHLENLgeRFYRVDKARSRQHG-GTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQDEE 463
Cdd:PRK10618 608 GAGVSIKELDNL--HFPFLNQTQGDRYGkASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKMLAAD 676
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
246-453 |
6.87e-10 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 61.23 E-value: 6.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 246 VSHELRTPLSYIKGYSEAILDGVAKG-PQQEKVTQLIH---KEADRMQRLVHDLLDLA---QLEGehfplkkQPIVFSQL 318
Cdd:PRK13557 170 IAHDFNNLLQVMSGYLDVIQAALSHPdADRGRMARSVEnirAAAERAATLTQQLLAFArkqRLEG-------RVLNLNGL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 319 IEDVLDTYEIKFIEKkIRISTNLNPEII-VMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQID-------------- 383
Cdd:PRK13557 243 VSGMGELAERTLGDA-VTIETDLAPDLWnCRIDPTQAEVALLNVLINARDAMPEGGRVTIRTRNVEiededlamyhglpp 321
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1695318305 384 -DYCELNIKDTGIGIDIEHLENLGERFYRvdkarSRQHG-GTGLGLAIVRQIVHIHDGQWRIESEKGNGTTV 453
Cdd:PRK13557 322 gRYVSIAVTDTGSGMPPEILARVMDPFFT-----TKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTV 388
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
352-459 |
2.88e-09 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 54.92 E-value: 2.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 352 DRMQQVLHNVLDNAIRYTNQN---GDIIITLRQIDDYCELNIKDTGIGIDIEHLEnlgerfyrvDKARSRQHGgtGLGLA 428
Cdd:COG2172 33 DDLVLAVSEAVTNAVRHAYGGdpdGPVEVELELDPDGLEIEVRDEGPGFDPEDLP---------DPYSTLAEG--GRGLF 101
|
90 100 110
....*....|....*....|....*....|.
gi 1695318305 429 IVRQIVHihdgQWRIESEKGnGTTVSIKLKV 459
Cdd:COG2172 102 LIRRLMD----EVEYESDPG-GTTVRLVKRL 127
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-458 |
3.26e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 54.47 E-value: 3.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 350 DEDRMQQVLHNVLDNAIRYTN--QNGDIIITLRQIDDYCE---LNIKDTGIGIDIEHLENLGERfYRVDKARsrqhgGTG 424
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEgrPSDVGEVRIRVEADQDGrivLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTG 74
|
90 100 110
....*....|....*....|....*....|....
gi 1695318305 425 LGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLK 458
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-452 |
5.42e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 53.55 E-value: 5.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 354 MQQVLHNVLDNAIRYTNQNGD-----IIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYRVDKArsrqhgGTGLGLA 428
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCerrelTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100
....*....|....*....|....
gi 1695318305 429 IVRQIVHIHDGQWRIESEKGNGTT 452
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGAT 98
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
384-457 |
9.48e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 53.15 E-value: 9.48e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1695318305 384 DYCELNIKDTGIGIDIEHLENLGERFYRVDKARSrqhgGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:cd16919 46 NYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGK----GTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-453 |
3.37e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 51.63 E-value: 3.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 354 MQQVLHNVLDNAIR-YTNQNGDIII---TLRQIDDY-------CELNIKDTGIGIDIEHLENLgerFYRVDKARSrqhGG 422
Cdd:cd16918 1 LIQVFLNLVRNAAQaLAGSGGEIILrtrTQRQVTLGhprhrlaLRVSVIDNGPGIPPDLQDTI---FYPMVSGRE---NG 74
|
90 100 110
....*....|....*....|....*....|.
gi 1695318305 423 TGLGLAIVRQIVHIHDGqwRIESEKGNGTTV 453
Cdd:cd16918 75 TGLGLAIAQNIVSQHGG--VIECDSQPGHTV 103
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
254-462 |
3.24e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 51.54 E-value: 3.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 254 LSYIKGYSEAILDGVAKGPQQ-EKVTQLIHKEADRMQRLVHDLL-DLAQLEGEHFPLKKQpivFSQLIEDVLDTYEIKfi 331
Cdd:COG4585 69 LSAIKLQLEAARRLLDADPEAaREELEEIRELAREALAELRRLVrGLRPPALDDLGLAAA---LEELAERLLRAAGIR-- 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 332 ekkIRISTNLNPeiiVMIDEDRMQQVLHNV---LDNAIRY---TNqngdIIITLRQIDDYCELNIKDTGIGIDIEhlenl 405
Cdd:COG4585 144 ---VELDVDGDP---DRLPPEVELALYRIVqeaLTNALKHagaTR----VTVTLEVDDGELTLTVRDDGVGFDPE----- 208
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1695318305 406 gerfyrvdkarsrQHGGTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKLKVQDE 462
Cdd:COG4585 209 -------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| ActS_PrrB_HisK |
NF033792 |
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ... |
248-429 |
7.74e-07 |
|
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.
Pssm-ID: 468186 [Multi-domain] Cd Length: 423 Bit Score: 51.36 E-value: 7.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 248 HELRTPLSYIKGYSEAILDGVAKGPQQEKVTQLIHKEADRMQRLVHDLLDLAQLEGEHFplKKQPIvfSQLIEDVLDTYe 327
Cdd:NF033792 211 HELGTPLATIALVAKELERELPDDPPLREDAELLRSQAERCRDILRRLTSLGEEGDAHL--DRLPL--SALIEEAAAPH- 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 328 IKFiEKKIRISTNLNPEIIVMIdeDRMQQVLH---NVLDNAIRYTNQNgdIIITLRQIDDYCELNIKDTGIGIDIEHLEN 404
Cdd:NF033792 286 RGF-GKEIEVVVAGDPGEEPVI--RRNPEILYglgNLIENAVDFARST--VTVTASWDAESVTITIEDDGPGFPPDVLSR 360
|
170 180
....*....|....*....|....*..
gi 1695318305 405 LGERFY--RVDKARSRQHGGTGLGLAI 429
Cdd:NF033792 361 IGEPYVttRRGEERRPGGGGLGLGLFI 387
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
357-463 |
9.54e-07 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 51.07 E-value: 9.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 357 VLHNVLDNAIRYTNQ--NGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERFYrvdkarSRQHGGTGLGLAIVRQIV 434
Cdd:PRK11086 437 ILGNLIENALEAVGGeeGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQSV 510
|
90 100
....*....|....*....|....*....
gi 1695318305 435 HIHDGQWRIESEKGNGTTVSIKLKVQDEE 463
Cdd:PRK11086 511 ENLGGSIAVESEPGVGTQFFVQIPWDGER 539
|
|
| PRK10600 |
PRK10600 |
nitrate/nitrite two-component system sensor histidine kinase NarX; |
163-232 |
1.09e-06 |
|
nitrate/nitrite two-component system sensor histidine kinase NarX;
Pssm-ID: 182581 [Multi-domain] Cd Length: 569 Bit Score: 50.82 E-value: 1.09e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1695318305 163 LILAPLALAITLLTI-WIGRKIIiaitRPLSQMERVANHLATGDFSERITISSEDEIGRLGKAFNKMANSL 232
Cdd:PRK10600 128 RVFAVFMALLLVFTIiWLRRRLL----QPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSAEL 194
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
161-234 |
7.58e-06 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 48.31 E-value: 7.58e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1695318305 161 MGLILAplalaITLLTIWIGRKiiiAITRPLSQMERVANHLATGDFSE-RITISSEDEIGRLGKAFNKMANSLET 234
Cdd:PRK10935 158 LILILT-----LVFFTVRFTRR---QVVAPLNQLVTASQQIEKGQFDHiPLDTTLPNELGLLAKAFNQMSSELHK 224
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
362-457 |
3.72e-05 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 46.12 E-value: 3.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 362 LDNAIRYTNQNgDIIITLRQIDDYCELNIKDTGIGIDIEHLEnlgerfyrvdkarsrqhggTGLGLAIVRQIVHIHDGQW 441
Cdd:PRK11644 419 LNNIVKHADAS-AVTLQGWQQDERLMLVIEDDGSGLPPGSGQ-------------------QGFGLRGMRERVTALGGTL 478
|
90
....*....|....*.
gi 1695318305 442 RIESEkgNGTTVSIKL 457
Cdd:PRK11644 479 TISCT--HGTRLSVSL 492
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-457 |
7.28e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 41.39 E-value: 7.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 362 LDNAIRYTnQNGDIIITLRQIDDYCELNIKDTGIGIDiehlenlgerfyrvDKARSrqhGGTGLGLAIVRQIVHIHDGQW 441
Cdd:cd16917 9 LTNALKHA-GASRVRVTLSYTADELTLTVVDDGVGFD--------------GPAPP---GGGGFGLLGMRERAELLGGTL 70
|
90
....*....|....*.
gi 1695318305 442 RIESEKGNGTTVSIKL 457
Cdd:cd16917 71 TIGSRPGGGTRVTARL 86
|
|
| HATPase_Phy-like |
cd16932 |
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana ... |
350-449 |
6.12e-04 |
|
Histidine kinase-like ATPase domain of plant phytochromes similar to Arabidopsis thaliana Phytochrome A, B, C, D and E; This family includes the histidine kinase-like ATPase (HATPase) domains of plant red/far-red photoreceptors, the phytochromes, and includes the Arabidopsis thaliana phytochrome family phyA-phyE. Following red light absorption, biologically inactive forms of phytochromes convert to active forms, which rapidly convert back to inactive forms upon far-red light irradiation. Phytochromes can be considered as having an N-terminal photosensory region to which a bilin chromophore is bound, and a C-terminal output region, which includes the HATPase domain represented here, and is involved in dimerization and presumably contributes to relaying the light signal to downstream signaling events.
Pssm-ID: 340409 [Multi-domain] Cd Length: 113 Bit Score: 39.56 E-value: 6.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 350 DEDRMQQVLHNVLDNAIRYTNQNGD-----IIITLRQIDD-----YCELNIKDTGIGIDiehlENLGERFYRVDKARSRQ 419
Cdd:cd16932 3 DQIRLQQVLADFLLNAVRFTPSPGGwveikVSPTKKQIGDgvhviHLEFRITHPGQGLP----EELVQEMFEENQWTTQE 78
|
90 100 110
....*....|....*....|....*....|
gi 1695318305 420 hggtGLGLAIVRQIVHIHDGQWRIESEKGN 449
Cdd:cd16932 79 ----GLGLSISRKLVKLMNGDVRYLREAGR 104
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
364-457 |
1.80e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 37.63 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 364 NAIRYTN---QNGDIIITLRQIDDYCELNIKDTGIGIDiehlenlgerfYRVDKARSRQHGGTGLGLAIVRQIVHihdgQ 440
Cdd:cd16936 11 NAVRHAYrhdGPGPVRLELDLDPDRLRVEVTDSGPGFD-----------PLRPADPDAGLREGGRGLALIRALMD----E 75
|
90
....*....|....*..
gi 1695318305 441 WRIESEkGNGTTVSIKL 457
Cdd:cd16936 76 VGYRRT-PGGKTVWLEL 91
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
347-457 |
2.00e-03 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 38.21 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1695318305 347 VMIDEDRMQQVLHNVLDNAIRYTNQNGDIIITLRQIDDYCELNIKDTGIGIDIEHLENLGERF-YRVDKARS-------- 417
Cdd:cd16938 5 VVGDERRVFQVLLHMLGNLLKMRNGGGNITFRVFLEGGSEDRSDRDWGPWRPSMSDESVEIRFeVEINDSGSpsiesasm 84
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1695318305 418 -----RQHG----GTGLGLAIVRQIVHIHDGQWRIESEKGNGTTVSIKL 457
Cdd:cd16938 85 rnslnRRYNlselGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| HATPase_TopVIB-like |
cd16933 |
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ... |
356-428 |
8.30e-03 |
|
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 37.71 E-value: 8.30e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1695318305 356 QVLHNVLDNAIRYTNQNG---DIIITLRQID-DYCELNIKDTGIGIDIEHLENLGERFYRVDKARSRQHGGT-GLGLA 428
Cdd:cd16933 22 TTVRELVENSLDATEEAGilpDIKVEIEEIGkDHYKVIVEDNGPGIPEEQIPKVFGKVLYGSKYHNKQSRGQqGLGIS 99
|
|
| |
