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Conserved domains on  [gi|1698227116|ref|WP_141544247|]
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4'-phosphopantetheinyl transferase superfamily protein, partial [Bacillus thuringiensis]

Protein Classification

4'-phosphopantetheinyl transferase family protein( domain architecture ID 11450000)

4-phosphopantetheinyl transferase family protein containing an ACPS (holo-[ACP] synthase) domain; ACPS transfers the 4'-phosphopantetheine moiety from coenzyme A to a serine of an acyl-carrier-protein (ACP)

CATH:  3.90.470.20
EC:  2.7.8.7
Gene Ontology:  GO:0008897
PubMed:  8939709

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sfp COG2091
Phosphopantetheinyl transferase [Coenzyme transport and metabolism];
2-51 1.13e-13

Phosphopantetheinyl transferase [Coenzyme transport and metabolism];


:

Pssm-ID: 441694  Cd Length: 177  Bit Score: 63.44  E-value: 1.13e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1698227116   2 FFSAEEFYDISNMNSNEKINYFYDLWTLKESYIKTIGKGLYTPLNSFSIK 51
Cdd:COG2091   128 FFSPEERAWLAALPQDDRLEAFTRLWTLKEALLKATGTGLSLPLRALAVE 177
 
Name Accession Description Interval E-value
Sfp COG2091
Phosphopantetheinyl transferase [Coenzyme transport and metabolism];
2-51 1.13e-13

Phosphopantetheinyl transferase [Coenzyme transport and metabolism];


Pssm-ID: 441694  Cd Length: 177  Bit Score: 63.44  E-value: 1.13e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1698227116   2 FFSAEEFYDISNMNSNEKINYFYDLWTLKESYIKTIGKGLYTPLNSFSIK 51
Cdd:COG2091   128 FFSPEERAWLAALPQDDRLEAFTRLWTLKEALLKATGTGLSLPLRALAVE 177
ACPS pfam01648
4'-phosphopantetheinyl transferase superfamily; Members of this family transfers the 4 ...
 2-83 2.17e-07

4'-phosphopantetheinyl transferase superfamily; Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of pfam00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP. This superfamily consists of two subtypes: The ACPS type and the Sfp type. The structure of the Sfp type is known, which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.


Pssm-ID: 426364 [Multi-domain]  Cd Length: 111  Bit Score: 45.68  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698227116   2 FFSAEEFYDISNMnSNEKINYFYDLWTLKESYIKTIGKGL--YTPLNSFSIKK--ESRTSISYKNIPKNFYFKQYNIDPN 77
Cdd:pfam01648  27 IFTPEERALLASL-PAEARRAFARLWTAKEAVFKALGPGLskLLDFDDIEVLLdpDGRPTLRLLGEAADLAWRFEVLAGD 105


                  ....*.
gi 1698227116  78 YKLSAC 83
Cdd:pfam01648 106 YALAVA 111
pantethn_trn TIGR00556
phosphopantetheine--protein transferase domain; This model models a domain active in ...
 1-48 3.04e-05

phosphopantetheine--protein transferase domain; This model models a domain active in transferring the phophopantetheine prosthetic group to its attachment site on enzymes and carrier proteins. Many members of this family are small proteins that act on the acyl carrier protein involved in fatty acid biosynthesis. Some members are domains of larger proteins involved specialized pathways for the synthesis of unusual molecules including polyketides, atypical fatty acids, and antibiotics. [Protein fate, Protein modification and repair]


Pssm-ID: 273136 [Multi-domain]  Cd Length: 128  Bit Score: 40.50  E-value: 3.04e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1698227116   1 EFFSAEEFYDISNMNSNEKINYFYDLWTLKESYIKTIGKGLYTPLNSF 48
Cdd:TIGR00556  28 RFFTPSEIEDYCKLSPKSQTESLAGRWAAKEAFIKALGKGISLGELLF 75
 
Name Accession Description Interval E-value
Sfp COG2091
Phosphopantetheinyl transferase [Coenzyme transport and metabolism];
2-51 1.13e-13

Phosphopantetheinyl transferase [Coenzyme transport and metabolism];


Pssm-ID: 441694  Cd Length: 177  Bit Score: 63.44  E-value: 1.13e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1698227116   2 FFSAEEFYDISNMNSNEKINYFYDLWTLKESYIKTIGKGLYTPLNSFSIK 51
Cdd:COG2091   128 FFSPEERAWLAALPQDDRLEAFTRLWTLKEALLKATGTGLSLPLRALAVE 177
ACPS pfam01648
4'-phosphopantetheinyl transferase superfamily; Members of this family transfers the 4 ...
 2-83 2.17e-07

4'-phosphopantetheinyl transferase superfamily; Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of pfam00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP. This superfamily consists of two subtypes: The ACPS type and the Sfp type. The structure of the Sfp type is known, which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.


Pssm-ID: 426364 [Multi-domain]  Cd Length: 111  Bit Score: 45.68  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698227116   2 FFSAEEFYDISNMnSNEKINYFYDLWTLKESYIKTIGKGL--YTPLNSFSIKK--ESRTSISYKNIPKNFYFKQYNIDPN 77
Cdd:pfam01648  27 IFTPEERALLASL-PAEARRAFARLWTAKEAVFKALGPGLskLLDFDDIEVLLdpDGRPTLRLLGEAADLAWRFEVLAGD 105


                  ....*.
gi 1698227116  78 YKLSAC 83
Cdd:pfam01648 106 YALAVA 111
pantethn_trn TIGR00556
phosphopantetheine--protein transferase domain; This model models a domain active in ...
 1-48 3.04e-05

phosphopantetheine--protein transferase domain; This model models a domain active in transferring the phophopantetheine prosthetic group to its attachment site on enzymes and carrier proteins. Many members of this family are small proteins that act on the acyl carrier protein involved in fatty acid biosynthesis. Some members are domains of larger proteins involved specialized pathways for the synthesis of unusual molecules including polyketides, atypical fatty acids, and antibiotics. [Protein fate, Protein modification and repair]


Pssm-ID: 273136 [Multi-domain]  Cd Length: 128  Bit Score: 40.50  E-value: 3.04e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1698227116   1 EFFSAEEFYDISNMNSNEKINYFYDLWTLKESYIKTIGKGLYTPLNSF 48
Cdd:TIGR00556  28 RFFTPSEIEDYCKLSPKSQTESLAGRWAAKEAFIKALGKGISLGELLF 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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