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Conserved domains on  [gi|1698560087|ref|WP_141743508|]
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YSIRK-type signal peptide-containing protein, partial [Staphylococcus sp. HMSC077E12]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
repeat_SSSPR51 TIGR04308
surface protein repeat SSSPR-51; This repeat domain is designated SSRS51, Streptococcal and ...
 1319-1368 3.44e-09

surface protein repeat SSSPR-51; This repeat domain is designated SSRS51, Streptococcal and Staphylococcal Surface Protein Repeat of size 51. These repeats are homologous to the listerial repeats of pfam13461, but shorter on average by about 8 amino acids. Up to twelve tandem repeats can occur, on some of the longest proteins of their respective species. Nearly all member proteins carry the C-terminal sortase target sequence, LPXTG, recognizable by model TIGR01167. The repeat structure and probable surface location suggest a possible adhesion function. A protein with this class of repeats may have other classes as well.


:

Pssm-ID: 275115 [Multi-domain]  Cd Length: 48  Bit Score: 53.69  E-value: 3.44e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1698560087 1319 RYVDSEGNEVQETEEGTHDAPGIiaDKWQYTGQTAAENGITTHIYQRIQS 1368
Cdd:TIGR04308    1 RWVDENGNPLKPTEEGTKPPKDI--PGYEFVTTTTDENGNTTHIYKKVTT 48
YSIRK_signal TIGR01168
Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, ...
 3-49 5.43e-08

Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.


:

Pssm-ID: 273479 [Multi-domain]  Cd Length: 39  Bit Score: 50.17  E-value: 5.43e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1698560087    3 RKKSKQKdyfsnvQNKYSIRKFSVGITSILIgASVIFGANseAHAAE 49
Cdd:TIGR01168    1 AKKFNEK------QQKYSIRKLSVGVASVLV-ASLFFGGG--VAAAE 38
MSCRAMM_ClfA super family cl41352
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 16-226 4.44e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


The actual alignment was detected with superfamily member NF033609:

Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 51.45  E-value: 4.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   16 QNKYSIRKFSVGITSILIGASVIFG--ANSEAHAAE--IKSDDNTQKVVNKEYSDGISQEQQDKSLNLAqDKEKSNNVNK 91
Cdd:NF033609     6 KEKHAIRKKSIGVASVLVGTLIGFGllSSKEADASEnsVTQSDSASNESKSNDSSSVSAAPKTDDTNVS-DTKTSSNTNN 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   92 NKVTDVGTSDVLKDTKTAHENVQQQDNVASKEETTK-----KTPSAIDKNNTSAQSEVVTSSDATkTSTALNQVDRNQlS 166
Cdd:NF033609    85 GETSVAQNPAQQETTQSASTNATTEETPVTGEATTTatnqaNTPATTQSSNTNAEELVNQTSNET-TSNDTNTVSSVN-S 162

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087  167 SQSTSERPKKRVKRDVGTDdkqlvgefvfsGTNSNERRYNLTSDiVSNRRVTSTSFSYSA 226
Cdd:NF033609   163 PQNSTNAENVSTTQDTSTE-----------ATPSNNESAPQSTD-ASNKDVVNQAVNTSA 210
MucBP pfam06458
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
 1218-1295 1.52e-03

MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.


:

Pssm-ID: 461917 [Multi-domain]  Cd Length: 65  Bit Score: 38.48  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087 1218 YKTTDGEVLSPLVTVvnSQIEGTEYTATPATIPDrvtfettddgkvkktisYHLISTPENQSGTVVGK---QTIEVHYVY 1294
Cdd:pfam06458    4 YVDEDGNELADSTTL--TGKIGDTYTTEAKEIPG-----------------YTLVETPGNATGNATGTfteEPQTVTYVY 64


                   .
gi 1698560087 1295 E 1295
Cdd:pfam06458   65 T 65
MucBP pfam06458
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
 1138-1206 7.86e-03

MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.


:

Pssm-ID: 461917 [Multi-domain]  Cd Length: 65  Bit Score: 36.17  E-value: 7.86e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087 1138 VVKYTNESGNTIQNSLTSKGKKNTEYNVSVPQMIdrlnrHYKFVRVD-NQLDPTTGHYaKGQTKIVNLIY 1206
Cdd:pfam06458    1 TVNYVDEDGNELADSTTLTGKIGDTYTTEAKEIP-----GYTLVETPgNATGNATGTF-TEEPQTVTYVY 64
 
Name Accession Description Interval E-value
repeat_SSSPR51 TIGR04308
surface protein repeat SSSPR-51; This repeat domain is designated SSRS51, Streptococcal and ...
 1319-1368 3.44e-09

surface protein repeat SSSPR-51; This repeat domain is designated SSRS51, Streptococcal and Staphylococcal Surface Protein Repeat of size 51. These repeats are homologous to the listerial repeats of pfam13461, but shorter on average by about 8 amino acids. Up to twelve tandem repeats can occur, on some of the longest proteins of their respective species. Nearly all member proteins carry the C-terminal sortase target sequence, LPXTG, recognizable by model TIGR01167. The repeat structure and probable surface location suggest a possible adhesion function. A protein with this class of repeats may have other classes as well.


Pssm-ID: 275115 [Multi-domain]  Cd Length: 48  Bit Score: 53.69  E-value: 3.44e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1698560087 1319 RYVDSEGNEVQETEEGTHDAPGIiaDKWQYTGQTAAENGITTHIYQRIQS 1368
Cdd:TIGR04308    1 RWVDENGNPLKPTEEGTKPPKDI--PGYEFVTTTTDENGNTTHIYKKVTT 48
YSIRK_signal TIGR01168
Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, ...
 3-49 5.43e-08

Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.


Pssm-ID: 273479 [Multi-domain]  Cd Length: 39  Bit Score: 50.17  E-value: 5.43e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1698560087    3 RKKSKQKdyfsnvQNKYSIRKFSVGITSILIgASVIFGANseAHAAE 49
Cdd:TIGR01168    1 AKKFNEK------QQKYSIRKLSVGVASVLV-ASLFFGGG--VAAAE 38
YSIRK_signal pfam04650
YSIRK type signal peptide; Many surface proteins found in Streptococcus, Staphylococcus, and ...
 14-39 8.57e-07

YSIRK type signal peptide; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.


Pssm-ID: 428049 [Multi-domain]  Cd Length: 26  Bit Score: 46.22  E-value: 8.57e-07
                           10        20
                   ....*....|....*....|....*.
gi 1698560087   14 NVQNKYSIRKFSVGITSILIGASVIF 39
Cdd:pfam04650    1 EKKQRYSIRKLSVGVASVLIGTLLFL 26
SSSPR-51 pfam18877
SSSPR-51 domain; This repeat domain is designated SSSPR-51, Streptococcal and Staphylococcal ...
 1316-1365 1.59e-06

SSSPR-51 domain; This repeat domain is designated SSSPR-51, Streptococcal and Staphylococcal Surface Protein Repeat of size 51. These repeats are homologous to the listerial repeats of pfam06458, but shorter on average by about 8 amino acids.


Pssm-ID: 465895 [Multi-domain]  Cd Length: 48  Bit Score: 46.20  E-value: 1.59e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1698560087 1316 EVTRYVDSEGNEVQETEEGTHDAPGIiaDKWQYTGQTAAENGITTHIYQR 1365
Cdd:pfam18877    1 VVTRYVDENGNELAPPEDGTKPKKNI--EGYEYVKTVKDEDGNITHIYKK 48
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 16-226 4.44e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 51.45  E-value: 4.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   16 QNKYSIRKFSVGITSILIGASVIFG--ANSEAHAAE--IKSDDNTQKVVNKEYSDGISQEQQDKSLNLAqDKEKSNNVNK 91
Cdd:NF033609     6 KEKHAIRKKSIGVASVLVGTLIGFGllSSKEADASEnsVTQSDSASNESKSNDSSSVSAAPKTDDTNVS-DTKTSSNTNN 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   92 NKVTDVGTSDVLKDTKTAHENVQQQDNVASKEETTK-----KTPSAIDKNNTSAQSEVVTSSDATkTSTALNQVDRNQlS 166
Cdd:NF033609    85 GETSVAQNPAQQETTQSASTNATTEETPVTGEATTTatnqaNTPATTQSSNTNAEELVNQTSNET-TSNDTNTVSSVN-S 162

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087  167 SQSTSERPKKRVKRDVGTDdkqlvgefvfsGTNSNERRYNLTSDiVSNRRVTSTSFSYSA 226
Cdd:NF033609   163 PQNSTNAENVSTTQDTSTE-----------ATPSNNESAPQSTD-ASNKDVVNQAVNTSA 210
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 13-175 3.30e-05

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 48.23  E-value: 3.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   13 SNVQNK--YSIRKFSVGITSILIgASVIFGanSEAHAAEikSDDNTQKVVNKEYSDGiSQEQQDKSLNLAQDKEKS--NN 88
Cdd:NF033839     4 SNHERKmrYSIRKFSIGVASVAV-ASLFMG--SVVHATE--KEGSTQAATSSNRGNE-SQAEQRKELDLERDKAKKavSE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   89 VNKNKVTDVGTsdvlKDTKTAHEN----VQQQDNVASK-----EETTKKtpSAIDKNNTSAQSEVVTS-SDATKTSTALN 158
Cdd:NF033839    78 YKEKKVKEIYK----KSTKERHKNtvdlVNKLQNIKNEylnkiVESTSK--SQLQKLMMESQSKVDEAvSKFEKDSSSSS 151

                          170
                   ....*....|....*..
gi 1698560087  159 QVDRNQLSSQSTSERPK 175
Cdd:NF033839   152 SSGSSTKPETPQPENPE 168
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 19-135 4.61e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 44.62  E-value: 4.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   19 YSIRKFSVGITSILIgASVIFGanSEAHAAEIKSddnTQKVVNKEYSDGISQEQQDKSLNLAQD--KEKSNNVNKNKVT- 95
Cdd:NF033838    12 YSIRKFSIGVASVVV-ASLFLG--GVVHAEEVRG---GNNPTVTSSGNESQKEHAKEVESHLEKilSEIQKSLDKRKHTq 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1698560087   96 DVGTSDVLKDTKTAHENVQQQDNVASKEETTKKTPSAIDK 135
Cdd:NF033838    86 NVALNKKLSDIKTEYLYELNVLKEKSEAELTSKTKKELDA 125
MucBP pfam06458
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
 1218-1295 1.52e-03

MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.


Pssm-ID: 461917 [Multi-domain]  Cd Length: 65  Bit Score: 38.48  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087 1218 YKTTDGEVLSPLVTVvnSQIEGTEYTATPATIPDrvtfettddgkvkktisYHLISTPENQSGTVVGK---QTIEVHYVY 1294
Cdd:pfam06458    4 YVDEDGNELADSTTL--TGKIGDTYTTEAKEIPG-----------------YTLVETPGNATGNATGTfteEPQTVTYVY 64


                   .
gi 1698560087 1295 E 1295
Cdd:pfam06458   65 T 65
endo_SpGH101 NF040533
SpGH101 family endo-alpha-N-acetylgalactosaminidase; Members of this family are streptococcal ...
 18-176 2.21e-03

SpGH101 family endo-alpha-N-acetylgalactosaminidase; Members of this family are streptococcal surface proteins with a complex (and somewhat variable) architecture that includes a crosswall-targeting N-terminal YSIRK domain, a C-terminal cell wall-anchoring LPXTG domain, and a central endo-alpha-N-acetylgalactosaminidase that removes an O-linked disaccharide from host glycoproteins.


Pssm-ID: 439743 [Multi-domain]  Cd Length: 1694  Bit Score: 42.64  E-value: 2.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   18 KYSIRKFSVGITSILIGASVIFGANSEAHAAEIKSDDNtqkvVNKEYSDGISQEQQDKSLNLaqDKEKSnnvnknkVTDV 97
Cdd:NF040533    11 KYSIRKFSLGVASVMIGASFFGTSPVLADTAQVGSTAN----LPADLADALAKAKDDNGRDF--EAPKA-------GENQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   98 GTSDVLKDTKTAHENVQQQDNVASKEETTKKTPSAiDKNNTSAQSEVVTSSDATKTSTAL------NQVDRNQLSSQSTS 171
Cdd:NF040533    78 GSPEVTDGPKTEEELLALEKEKSATEKPKENKPAE-AKPETAKTVTPEWQTVARKEQQGTveireeNGVRYNQLSSTAQN 156


                   ....*
gi 1698560087  172 ERPKK 176
Cdd:NF040533   157 DNGAK 161
MucBP pfam06458
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
 1138-1206 7.86e-03

MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.


Pssm-ID: 461917 [Multi-domain]  Cd Length: 65  Bit Score: 36.17  E-value: 7.86e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087 1138 VVKYTNESGNTIQNSLTSKGKKNTEYNVSVPQMIdrlnrHYKFVRVD-NQLDPTTGHYaKGQTKIVNLIY 1206
Cdd:pfam06458    1 TVNYVDEDGNELADSTTLTGKIGDTYTTEAKEIP-----GYTLVETPgNATGNATGTF-TEEPQTVTYVY 64
 
Name Accession Description Interval E-value
repeat_SSSPR51 TIGR04308
surface protein repeat SSSPR-51; This repeat domain is designated SSRS51, Streptococcal and ...
 1319-1368 3.44e-09

surface protein repeat SSSPR-51; This repeat domain is designated SSRS51, Streptococcal and Staphylococcal Surface Protein Repeat of size 51. These repeats are homologous to the listerial repeats of pfam13461, but shorter on average by about 8 amino acids. Up to twelve tandem repeats can occur, on some of the longest proteins of their respective species. Nearly all member proteins carry the C-terminal sortase target sequence, LPXTG, recognizable by model TIGR01167. The repeat structure and probable surface location suggest a possible adhesion function. A protein with this class of repeats may have other classes as well.


Pssm-ID: 275115 [Multi-domain]  Cd Length: 48  Bit Score: 53.69  E-value: 3.44e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1698560087 1319 RYVDSEGNEVQETEEGTHDAPGIiaDKWQYTGQTAAENGITTHIYQRIQS 1368
Cdd:TIGR04308    1 RWVDENGNPLKPTEEGTKPPKDI--PGYEFVTTTTDENGNTTHIYKKVTT 48
YSIRK_signal TIGR01168
Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, ...
 3-49 5.43e-08

Gram-positive signal peptide, YSIRK family; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.


Pssm-ID: 273479 [Multi-domain]  Cd Length: 39  Bit Score: 50.17  E-value: 5.43e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1698560087    3 RKKSKQKdyfsnvQNKYSIRKFSVGITSILIgASVIFGANseAHAAE 49
Cdd:TIGR01168    1 AKKFNEK------QQKYSIRKLSVGVASVLV-ASLFFGGG--VAAAE 38
YSIRK_signal pfam04650
YSIRK type signal peptide; Many surface proteins found in Streptococcus, Staphylococcus, and ...
 14-39 8.57e-07

YSIRK type signal peptide; Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology. There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.


Pssm-ID: 428049 [Multi-domain]  Cd Length: 26  Bit Score: 46.22  E-value: 8.57e-07
                           10        20
                   ....*....|....*....|....*.
gi 1698560087   14 NVQNKYSIRKFSVGITSILIGASVIF 39
Cdd:pfam04650    1 EKKQRYSIRKLSVGVASVLIGTLLFL 26
SSSPR-51 pfam18877
SSSPR-51 domain; This repeat domain is designated SSSPR-51, Streptococcal and Staphylococcal ...
 1316-1365 1.59e-06

SSSPR-51 domain; This repeat domain is designated SSSPR-51, Streptococcal and Staphylococcal Surface Protein Repeat of size 51. These repeats are homologous to the listerial repeats of pfam06458, but shorter on average by about 8 amino acids.


Pssm-ID: 465895 [Multi-domain]  Cd Length: 48  Bit Score: 46.20  E-value: 1.59e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1698560087 1316 EVTRYVDSEGNEVQETEEGTHDAPGIiaDKWQYTGQTAAENGITTHIYQR 1365
Cdd:pfam18877    1 VVTRYVDENGNELAPPEDGTKPKKNI--EGYEYVKTVKDEDGNITHIYKK 48
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 16-226 4.44e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 51.45  E-value: 4.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   16 QNKYSIRKFSVGITSILIGASVIFG--ANSEAHAAE--IKSDDNTQKVVNKEYSDGISQEQQDKSLNLAqDKEKSNNVNK 91
Cdd:NF033609     6 KEKHAIRKKSIGVASVLVGTLIGFGllSSKEADASEnsVTQSDSASNESKSNDSSSVSAAPKTDDTNVS-DTKTSSNTNN 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   92 NKVTDVGTSDVLKDTKTAHENVQQQDNVASKEETTK-----KTPSAIDKNNTSAQSEVVTSSDATkTSTALNQVDRNQlS 166
Cdd:NF033609    85 GETSVAQNPAQQETTQSASTNATTEETPVTGEATTTatnqaNTPATTQSSNTNAEELVNQTSNET-TSNDTNTVSSVN-S 162

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087  167 SQSTSERPKKRVKRDVGTDdkqlvgefvfsGTNSNERRYNLTSDiVSNRRVTSTSFSYSA 226
Cdd:NF033609   163 PQNSTNAENVSTTQDTSTE-----------ATPSNNESAPQSTD-ASNKDVVNQAVNTSA 210
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 13-175 3.30e-05

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 48.23  E-value: 3.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   13 SNVQNK--YSIRKFSVGITSILIgASVIFGanSEAHAAEikSDDNTQKVVNKEYSDGiSQEQQDKSLNLAQDKEKS--NN 88
Cdd:NF033839     4 SNHERKmrYSIRKFSIGVASVAV-ASLFMG--SVVHATE--KEGSTQAATSSNRGNE-SQAEQRKELDLERDKAKKavSE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   89 VNKNKVTDVGTsdvlKDTKTAHEN----VQQQDNVASK-----EETTKKtpSAIDKNNTSAQSEVVTS-SDATKTSTALN 158
Cdd:NF033839    78 YKEKKVKEIYK----KSTKERHKNtvdlVNKLQNIKNEylnkiVESTSK--SQLQKLMMESQSKVDEAvSKFEKDSSSSS 151

                          170
                   ....*....|....*..
gi 1698560087  159 QVDRNQLSSQSTSERPK 175
Cdd:NF033839   152 SSGSSTKPETPQPENPE 168
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 19-135 4.61e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 44.62  E-value: 4.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   19 YSIRKFSVGITSILIgASVIFGanSEAHAAEIKSddnTQKVVNKEYSDGISQEQQDKSLNLAQD--KEKSNNVNKNKVT- 95
Cdd:NF033838    12 YSIRKFSIGVASVVV-ASLFLG--GVVHAEEVRG---GNNPTVTSSGNESQKEHAKEVESHLEKilSEIQKSLDKRKHTq 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1698560087   96 DVGTSDVLKDTKTAHENVQQQDNVASKEETTKKTPSAIDK 135
Cdd:NF033838    86 NVALNKKLSDIKTEYLYELNVLKEKSEAELTSKTKKELDA 125
MucBP pfam06458
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
 1218-1295 1.52e-03

MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.


Pssm-ID: 461917 [Multi-domain]  Cd Length: 65  Bit Score: 38.48  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087 1218 YKTTDGEVLSPLVTVvnSQIEGTEYTATPATIPDrvtfettddgkvkktisYHLISTPENQSGTVVGK---QTIEVHYVY 1294
Cdd:pfam06458    4 YVDEDGNELADSTTL--TGKIGDTYTTEAKEIPG-----------------YTLVETPGNATGNATGTfteEPQTVTYVY 64


                   .
gi 1698560087 1295 E 1295
Cdd:pfam06458   65 T 65
endo_SpGH101 NF040533
SpGH101 family endo-alpha-N-acetylgalactosaminidase; Members of this family are streptococcal ...
 18-176 2.21e-03

SpGH101 family endo-alpha-N-acetylgalactosaminidase; Members of this family are streptococcal surface proteins with a complex (and somewhat variable) architecture that includes a crosswall-targeting N-terminal YSIRK domain, a C-terminal cell wall-anchoring LPXTG domain, and a central endo-alpha-N-acetylgalactosaminidase that removes an O-linked disaccharide from host glycoproteins.


Pssm-ID: 439743 [Multi-domain]  Cd Length: 1694  Bit Score: 42.64  E-value: 2.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   18 KYSIRKFSVGITSILIGASVIFGANSEAHAAEIKSDDNtqkvVNKEYSDGISQEQQDKSLNLaqDKEKSnnvnknkVTDV 97
Cdd:NF040533    11 KYSIRKFSLGVASVMIGASFFGTSPVLADTAQVGSTAN----LPADLADALAKAKDDNGRDF--EAPKA-------GENQ 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087   98 GTSDVLKDTKTAHENVQQQDNVASKEETTKKTPSAiDKNNTSAQSEVVTSSDATKTSTAL------NQVDRNQLSSQSTS 171
Cdd:NF040533    78 GSPEVTDGPKTEEELLALEKEKSATEKPKENKPAE-AKPETAKTVTPEWQTVARKEQQGTveireeNGVRYNQLSSTAQN 156


                   ....*
gi 1698560087  172 ERPKK 176
Cdd:NF040533   157 DNGAK 161
MucBP pfam06458
MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial ...
 1138-1206 7.86e-03

MucBP domain; The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins, in several repeats. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with pfam00746 and pfam00560.


Pssm-ID: 461917 [Multi-domain]  Cd Length: 65  Bit Score: 36.17  E-value: 7.86e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1698560087 1138 VVKYTNESGNTIQNSLTSKGKKNTEYNVSVPQMIdrlnrHYKFVRVD-NQLDPTTGHYaKGQTKIVNLIY 1206
Cdd:pfam06458    1 TVNYVDEDGNELADSTTLTGKIGDTYTTEAKEIP-----GYTLVETPgNATGNATGTF-TEEPQTVTYVY 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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