|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
3-397 |
1.55e-45 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 163.48 E-value: 1.55e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 3 VLKNYAYNLSYQLLVIILPIITTPYVTRVFSSTDLGTYGYFNSIVTYFILLATLGVANYGTKEISGHRKDIRKNFwgIYT 82
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYRKEKIREI--IST 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 83 LQFGATVLSICLYILLCLSLSFMQN------PVAYILGLSLVSKGMDISWL--FQGLEDFRKITVRNITVKLVGVISIFL 154
Cdd:cd13128 79 SLVLKLILGILALLLLFLFAFLIAFydpelvLLLYILALSLPFSALNSLFRgiFQGFEKMKYIVIARIIESVLSLILALI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 155 FVKSANDLYLYVFLLT---IFELLGQFSMWWPAREFIGKPHFDWSYAKQHLKPVILLFLPQIAISLYVTLDRTMLGALAS 231
Cdd:cd13128 159 LVLLGGGLIGFALAYLiasVLSAILLLYIYRKKILLPKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 232 AKDVGIYDQALKLVNILLTLVTSLGSVMLPRVANLLSTgDHKAVNKMHQMSFLIYNLVIFPIIAGMLIVNDDFVQFFLGQ 311
Cdd:cd13128 239 DAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYKN-DKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGE 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 312 DFQDAKYAIAIMIFRMFFIGWTNIMGiQILIPHNKNKEFMISTTIPAIVSVGLNLLLLPKLGYIGAAIVSVLTEALVWAI 391
Cdd:cd13128 318 EYLPAALVLQILAWGFLFIFLNGIFG-SILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFIL 396
|
....*.
gi 1705200043 392 QLYFTR 397
Cdd:cd13128 397 LLYLLK 402
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
1-393 |
2.46e-36 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 137.39 E-value: 2.46e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 1 MKVLKNYAYNLSYQLLVIILPIITTPYVTRVFSSTDLGTYGYFNSIVTYFILLATLGVANYGTKEISGHRKDIRKNFWG- 79
Cdd:COG2244 2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEELRRLLSt 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 80 IYTLQFGATVLSICLYILLCLSLSFMQN-----PVAYILGLSLVSKGMD--ISWLFQGLEDFRKITVRNITVKLVGVISI 152
Cdd:COG2244 82 ALLLRLLLSLLLALLLLLLAPFIAALLGepelaLLLLLLALALLLSALSavLLALLRGLERFKLLALINILSSLLSLLLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 153 FLFVKSANDLYLYVFlltifellgQFSMWwparefigkphfdwsyakqhlkpvilLFLPQIAISLYVTLDRTMLGALASA 232
Cdd:COG2244 162 LLLALLGLGLWGLVL---------KYSLP--------------------------LLLSGLLGLLLTNLDRLLLGALLGP 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 233 KDVGIYDQALKLVNILLTLVTSLGSVMLPRVANLLSTGDHKAVNKMHQMSFLIYNLVIFPIIAGMLIVNDDFVQFFLGQD 312
Cdd:COG2244 207 AAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPE 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 313 FQDAKYAIAIMIFRMFFIGWTNIMGiQILIPHNKNKEFMISTTIPAIVSVGLNLLLLPKLGYIGAAIVSVLTEALVWAIQ 392
Cdd:COG2244 287 YAEAAPVLPILALGALFLALSGVLS-NLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLL 365
|
.
gi 1705200043 393 L 393
Cdd:COG2244 366 L 366
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
3-260 |
2.97e-15 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 75.80 E-value: 2.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 3 VLKNYAYNLSYQLLVIILPIITTPYVTRVFSSTDLGTYGYFNSIVTYFILLATLGVANYGTKEISGHRKDIRKNFWGIYT 82
Cdd:pfam01943 1 LLKNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAKYREKYELVSLYWLN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 83 LQFGATVLSIcLYILLCLSLSFMQNP-------VAYILGLSLVSKGMDISWLFQGLEDFRKITVRNITVKLVGVISIFLF 155
Cdd:pfam01943 81 ALLVKLVLVL-LFLLLPLIAAFLGLPelavlyrILALMFLLLPGVVQFRRGLFQGLERMKYALISQIVESLSRVILVFIA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 156 VKSANDLYLYVFLLTIFELLGQFSMWWPAREFIGKPH--FDWSYAKQHLKPVILLFLPQIAISLYVTLDRTMLGALASAK 233
Cdd:pfam01943 160 VFLPGDIVAALLYQVLAALVGGIIALAVLRKIFRPRFvfPSLKLVRKLLSFGAPLFISSLAISLYTYIDSILLGLLLGAG 239
|
250 260
....*....|....*....|....*..
gi 1705200043 234 DVGIYDQALKLVNILLTLVTSLGSVML 260
Cdd:pfam01943 240 AVGIYNAAYQLLVAIQGLLNPIVTAVL 266
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
3-397 |
1.55e-45 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 163.48 E-value: 1.55e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 3 VLKNYAYNLSYQLLVIILPIITTPYVTRVFSSTDLGTYGYFNSIVTYFILLATLGVANYGTKEISGHRKDIRKNFwgIYT 82
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYRKEKIREI--IST 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 83 LQFGATVLSICLYILLCLSLSFMQN------PVAYILGLSLVSKGMDISWL--FQGLEDFRKITVRNITVKLVGVISIFL 154
Cdd:cd13128 79 SLVLKLILGILALLLLFLFAFLIAFydpelvLLLYILALSLPFSALNSLFRgiFQGFEKMKYIVIARIIESVLSLILALI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 155 FVKSANDLYLYVFLLT---IFELLGQFSMWWPAREFIGKPHFDWSYAKQHLKPVILLFLPQIAISLYVTLDRTMLGALAS 231
Cdd:cd13128 159 LVLLGGGLIGFALAYLiasVLSAILLLYIYRKKILLPKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 232 AKDVGIYDQALKLVNILLTLVTSLGSVMLPRVANLLSTgDHKAVNKMHQMSFLIYNLVIFPIIAGMLIVNDDFVQFFLGQ 311
Cdd:cd13128 239 DAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYKN-DKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGE 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 312 DFQDAKYAIAIMIFRMFFIGWTNIMGiQILIPHNKNKEFMISTTIPAIVSVGLNLLLLPKLGYIGAAIVSVLTEALVWAI 391
Cdd:cd13128 318 EYLPAALVLQILAWGFLFIFLNGIFG-SILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFIL 396
|
....*.
gi 1705200043 392 QLYFTR 397
Cdd:cd13128 397 LLYLLK 402
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
1-393 |
2.46e-36 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 137.39 E-value: 2.46e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 1 MKVLKNYAYNLSYQLLVIILPIITTPYVTRVFSSTDLGTYGYFNSIVTYFILLATLGVANYGTKEISGHRKDIRKNFWG- 79
Cdd:COG2244 2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEELRRLLSt 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 80 IYTLQFGATVLSICLYILLCLSLSFMQN-----PVAYILGLSLVSKGMD--ISWLFQGLEDFRKITVRNITVKLVGVISI 152
Cdd:COG2244 82 ALLLRLLLSLLLALLLLLLAPFIAALLGepelaLLLLLLALALLLSALSavLLALLRGLERFKLLALINILSSLLSLLLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 153 FLFVKSANDLYLYVFlltifellgQFSMWwparefigkphfdwsyakqhlkpvilLFLPQIAISLYVTLDRTMLGALASA 232
Cdd:COG2244 162 LLLALLGLGLWGLVL---------KYSLP--------------------------LLLSGLLGLLLTNLDRLLLGALLGP 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 233 KDVGIYDQALKLVNILLTLVTSLGSVMLPRVANLLSTGDHKAVNKMHQMSFLIYNLVIFPIIAGMLIVNDDFVQFFLGQD 312
Cdd:COG2244 207 AAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLLFGPE 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 313 FQDAKYAIAIMIFRMFFIGWTNIMGiQILIPHNKNKEFMISTTIPAIVSVGLNLLLLPKLGYIGAAIVSVLTEALVWAIQ 392
Cdd:COG2244 287 YAEAAPVLPILALGALFLALSGVLS-NLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLLLLL 365
|
.
gi 1705200043 393 L 393
Cdd:COG2244 366 L 366
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
3-401 |
1.48e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 78.30 E-value: 1.48e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 3 VLKNYAYNLSYQLLVIILPIITTPYVTRVFSSTDLGTYGYFNSIVTYFILLATLGVANYGTkeisgHRKDIRKNFWG-IY 81
Cdd:cd13127 1 AVSGAFWSAISQVVVQLLQFVVTIILARLLTPEDFGLVAMATVFIAFAQLFSDLGLSSALI-----QRKDLTEEDLStVF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 82 TLQFGatvLSICLYILLCLSL----SFMQNPvayilGLSLVSKGMDISWLFQGLE-----------DFRKITVRNITVKL 146
Cdd:cd13127 76 WLNLL---LGLLLYLLLFLLApliaAFYNEP-----ELIPLLRVLSLSFLLSGLGsvprallqrelRFKKLAIIELISTL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 147 VG-VISIFLFVKSANdLYLYVFLLTIFELLGQFSMWWPAREFIgKPHFDWSYAKQHLKPVILLFLPQIAISLYVTLDRTM 225
Cdd:cd13127 148 VSgVVAIVLALLGFG-VWALVAQQLVGALVSTVLLWILSRWRP-RLSFSLASLKELLSFGSKLLGSNLLNYFSRNLDNLI 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 226 LGALASAKDVGIYDQALKLVNILLTLVTS-LGSVMLPRVANLlsTGDHKAVNKMHQMSFLIYNLVIFPIIAGMLIVNDDF 304
Cdd:cd13127 226 IGKFLGAAALGYYSRAYRLALLPVQNITGpITRVLFPALSRL--QDDPERLRRAYLKALRLLALITFPLMVGLALLAEPL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 305 VQFFLGQDFQDAKYAIAIMIFRMFFIGWTNIMGiQILIPHNKNKEFMISTTIPAIVSVGlNLLLLPKLGYIGAAIVSVLT 384
Cdd:cd13127 304 VLLLLGEKWLPAVPILQILALAGLFQPLSSLNG-SLLLALGRTDLLLKLGLIKAVLTVL-ALLIGIPYGIIGVAIAYVIA 381
|
410
....*....|....*..
gi 1705200043 385 EALVWAIQLYFTRNYLK 401
Cdd:cd13127 382 SLLSFPLNLYLAGRLIG 398
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
3-260 |
2.97e-15 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 75.80 E-value: 2.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 3 VLKNYAYNLSYQLLVIILPIITTPYVTRVFSSTDLGTYGYFNSIVTYFILLATLGVANYGTKEISGHRKDIRKNFWGIYT 82
Cdd:pfam01943 1 LLKNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAKYREKYELVSLYWLN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 83 LQFGATVLSIcLYILLCLSLSFMQNP-------VAYILGLSLVSKGMDISWLFQGLEDFRKITVRNITVKLVGVISIFLF 155
Cdd:pfam01943 81 ALLVKLVLVL-LFLLLPLIAAFLGLPelavlyrILALMFLLLPGVVQFRRGLFQGLERMKYALISQIVESLSRVILVFIA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 156 VKSANDLYLYVFLLTIFELLGQFSMWWPAREFIGKPH--FDWSYAKQHLKPVILLFLPQIAISLYVTLDRTMLGALASAK 233
Cdd:pfam01943 160 VFLPGDIVAALLYQVLAALVGGIIALAVLRKIFRPRFvfPSLKLVRKLLSFGAPLFISSLAISLYTYIDSILLGLLLGAG 239
|
250 260
....*....|....*....|....*..
gi 1705200043 234 DVGIYDQALKLVNILLTLVTSLGSVML 260
Cdd:pfam01943 240 AVGIYNAAYQLLVAIQGLLNPIVTAVL 266
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
319-458 |
5.13e-11 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 60.28 E-value: 5.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 319 AIAIMIFRMFFIGWTNIMGiQILIPHNKNKEFMISTTIPAIVSVGLNLLLLPKLGYIGAAIVSVLTEALVWAIQLYFTRN 398
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLT-SILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRR 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1705200043 399 YLKEVPLLASTVKIIGASALMYSVLFVVKTTVNITPVINVMVFAA--TGAVLYISQILFLKV 458
Cdd:pfam14667 80 YLGLRLLLRRLLKPLLAALVMGIVVYLLLLLLGLLLGLALALLLAvlVGALVYLLLLLLLKL 141
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
180-458 |
1.81e-08 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 56.70 E-value: 1.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 180 MWWPAREFIGKPHFDWSYAKQHLKPVILLFLPQIA------ISLYVTldrTMLGALASAKDVGIYDQALKLVNILLTLV- 252
Cdd:COG0728 199 QLPALRRLGLRLRPRFDLRDPGVRRVLKLMLPALLgvsvsqINLLVD---TILASFLPEGSVSALYYADRLYQLPLGLFg 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 253 TSLGSVMLPRVANLLSTGDHKAVNKMHQMSFLIYNLVIFPIIAGMLIVNDDFVQFFLGQDFQDAKYAIAI-MIFRMFFIG 331
Cdd:COG0728 276 VAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFERGAFTAEDTALTaLALAAYALG 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 332 WTNIMGIQILIP----HNKNKEFMISTTIPAIVSVGLNLLLLPKLGYIGAAI---VSVLTEALVWAIQLYFTRNYLKEVP 404
Cdd:COG0728 356 LPAFALVKVLARafyaRQDTRTPVRIAVIAVVVNIVLNLLLVPPLGHAGLALatsLSALVNALLLLVLLRRRLGGLPLRG 435
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1705200043 405 LLASTVKIIGASALMYSVLFVVKTTVN-------ITPVINVMVFAATGAVLYISQILFLKV 458
Cdd:COG0728 436 ILRTLLKLLLASLVMGAVLWLLLRLLGdwlggglLGRLLALALLILVGAAVYFALLLLLGV 496
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
5-400 |
6.66e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 51.39 E-value: 6.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 5 KNYAYNLSYQLLVIILPIITTPYVTRVFSSTDLGTYGYFNSIVTYFILLATLGVANYGTKEISGHRKDIRKNFWGIYTLQ 84
Cdd:cd13125 1 KVSSLSGISTLIKILAGLIINKVVAVYLGPSGVALLGQLQNFVTILQTIAGGGINNGVVKYTAEYKDDEEKLARVWSTAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 85 FGATVLSICLYILLC-----LSLSFMQNP----VAYILGLSLVSKGMD--ISWLFQGLEDFRKITVRNITVKLVGVISIF 153
Cdd:cd13125 81 RITLILSILGGLLLLlfskpLSSLLFGDIdyswVFILLGLALPLFALNnlLLAILNGLKEIKRYALINIISSLIGLLVSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 154 LFVKSANDLYLYVFLLTIFELLGqFSMWWPAR--EFIGKPHFDWSYAKQHLKPVILLFLPQIAISLYVTLD----RTMLG 227
Cdd:cd13125 161 LLVYFYGLKGALLALVLNQSLIF-LVTLIYSRkqPWFKLKYLWGRLDKDIIKKLLKFSLMALVSALSLPLSqiivRNILI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 228 ALASAKDVGIYDQALKLVNILLTLVT-SLGSVMLPRVAnllSTGDHKAVNKMHQMSFLIYNLVIFPIIAGMLIVNDDFVQ 306
Cdd:cd13125 240 RQLGWEAAGYWQAVWKISDVYLGFITtALSTYYLPRLS---AIKDNKELKREVNKQLKVILPLVAIGALLIYLLRDLIIQ 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 307 FFLGQDFQDAKYAIAIMIFRMFFIGWTNIMGIqILIPHNKNKEFMISTTIPAIVSVGLNLLLLPKLGYIGAAIVSVLTEA 386
Cdd:cd13125 317 ILFSEEFLPARELFLWQLIGDFFKIASWLLGY-ILLAKGMTKLFIITEILFALLFVLLSLLFIPLFGLEGAGIAYAINYI 395
|
410
....*....|....
gi 1705200043 387 LVWAIQLYFTRNYL 400
Cdd:cd13125 396 LYLILMYFIFRKLL 409
|
|
| Polysacc_synt_3 |
pfam13440 |
Polysaccharide biosynthesis protein; |
28-311 |
1.87e-06 |
|
Polysaccharide biosynthesis protein;
Pssm-ID: 404342 [Multi-domain] Cd Length: 293 Bit Score: 49.51 E-value: 1.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 28 VTRVFSSTDLGTYGYFNSIVTYFILLATLGVANygtkeISGHRKDIRKNFWG-IYTLQFgatVLSICLYILLCLSL---- 102
Cdd:pfam13440 2 LARLLSPEDFGVVAIATVVISFANIFVDMGFSS-----ALIQKKDITETDYStVFTFNL---IFGALIYLILFALAplia 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 103 SFMQNPVAY----ILGLSLVSKGMDI--SWLFQGLEDFRKITVRNITVKLVGVISIFLFVKsandLYLYVFLLTIFELLG 176
Cdd:pfam13440 74 SFYNQPELVpvlrVLALVLILNGLSSvqTALLRRDLRFKKLFKITLTSSVIGGIVGIVLAY----LGFGVWALVIGTLAQ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 177 QFSMW---WPAREFIGKPHFDWSYAKQHLKPVILLFLPQIAISLYVTLDRTMLGALASAKDVGIYDQALKLVNILLTLVT 253
Cdd:pfam13440 150 QLLSLvllWLASDWRPRLTFSLKVIKELFSFGSWLLLSNLLNYLARNLDNLIIGKVLGTAALGLYSVAYRLALLPTANIT 229
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1705200043 254 S-LGSVMLPRVANLlsTGDHKAVNKMHQMSFLIYNLVIFPIIAGMLIVNDDFVQFFLGQ 311
Cdd:pfam13440 230 SvITKVLFPALSRI--QDDKAKLRELYLRVLRLIAFIVFPIMAGLAVVAEPLVLVLLGS 286
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
37-401 |
4.68e-05 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 45.54 E-value: 4.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 37 LGTYGYFNSIVTYFILLATLGVANYGTKEIS-----GHRKDIRKNFW-GIYTLQFGATVLSICLYILL-CLSLSFMQNPV 109
Cdd:cd13124 30 MGLYQMAYPIYGIFLTLATAGIPVAISKLVAeynalGDYKGARRIFRvSLILLLILGLVFFLLLFFGApFLAQLLLGDPR 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 110 AY-----------ILGLSLVSKGmdiswLFQGLEDFRKITVRNITVKLVGVISI----FLFVKSANDLYLYV----FLLT 170
Cdd:cd13124 110 LApviralapailIVPLLSVLRG-----YFQGLQNMTPTAVSQVIEQIVRVIVIlvlaYLLLPVGGGLYYAAagatFGAV 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 171 IFELLGQFSMWWPAREFIGKPHFDWSYAKQHLKPVILLFLPQIAISLYVTLDRTM--------------------LGALA 230
Cdd:cd13124 185 IGALAGLLVLLYYYRKKRRELKRLLRKSPRSKISTKEILKELLSYAIPITLSSLIlpllqlidsftvprrlqaagLSESE 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 231 SAKDVGIY-DQALKLVNILLTLVTSLGSVMLPRVANLLSTGDHKAVNKMHQMSFLIYNLVIFPIIAGMLIVNDDFVQFFL 309
Cdd:cd13124 265 ATALYGILtGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLF 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 310 GQDfqDAKYAIAIMIFRMFFIGWTNIMgIQILIPHNKNKEFMISTTIPAIVSVGLNLLLLPKLGYIGAAIVSVLTEALVW 389
Cdd:cd13124 345 GDS--EGGLILQILAPSILFLSLQQVT-AAILQGLGKVKIPVINLLIGLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAA 421
|
410
....*....|..
gi 1705200043 390 AIQLYFTRNYLK 401
Cdd:cd13124 422 LLNLRALKKLLG 433
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
188-397 |
2.24e-03 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 40.38 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 188 IGKPHFDWSYAKQHLKPVILLFLPQIAISLYVTLDRTMLGALASAKDVGIYDQALKLVNILLTLVTSLGSVMLPRVANLL 267
Cdd:cd12082 208 LSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 268 STGDHKAVNKMHQMSfLIYNLVIFPIIAGMLIVNDDFVQ--FFLGQDFQD-AKYAIAIMIFRMFFIGWTNIMGiQILIPH 344
Cdd:cd12082 288 GAGNFDRARRITWVA-LLIGLLIGAVLGLLILLFPEPILslFTNDPEFLElAVSYLRILAIYYLFVGIGYVLQ-AGFQAA 365
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1705200043 345 NKNKEFMISTTIPAIVSVGLNLLLLPKLGY--IGAAIVSVLTEALVWAIQLYFTR 397
Cdd:cd12082 366 GRTLKSLIVSLLSYWVVRLPLAYVLAYLGLglYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
180-336 |
3.56e-03 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 39.74 E-value: 3.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 180 MWWPAREFIGKPHFDWSYAKQHLKPVILLFLPQIA------ISLYVTldrTMLGALASAKDVGIYDQALKLVNILLTLV- 252
Cdd:cd13123 192 QLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPALLgvsvsqINLLVD---TILASFLPEGSISALYYADRLYQLPLGIFg 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1705200043 253 TSLGSVMLPRVANLLSTGDHKAVNKMHQMSFLIYNLVIFPIIAGMLIVNDDFVQFFLGQ---DFQDAKY---AIAIMIFR 326
Cdd:cd13123 269 VAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFERgafTAEDTLMtasALAAYALG 348
|
170
....*....|
gi 1705200043 327 MFFIGWTNIM 336
Cdd:cd13123 349 LPAFALVKLL 358
|
|
| |
